Abstract: A microfluidic-based device and system is disclosed for the high-throughput intracellular delivery of biomolecular cargo to cells (eukaryotic or prokaryotic) or enveloped viruses. Cargo integration occurs due to transient membrane permeabilization by exposure to bulk acoustic waves (BAWs) transduced from surface acoustic waves (SAWs) generated by a rapidly oscillating piezoelectric substrate. In this approach, temporary pores are established across the cellular membrane as cells are partially deformed and squeezed or subject to shearing forces as they travel through the vibrational modes created within the microfludic channel(s) of the device.

Abstract: Generation of bubbles is disclosed to occur within a flow of an aqueous fluid. The bubbles may be formed within a tube of a selected diameter and the bubbles are controlled to exit the tube at a selected diameter. Generally, bubbles are formed to include a diameter of less than 1 millimeter, including less than about 20 microns.

Abstract: A basalt-fiber-reinforced thermoplastic composite material may include a thermoplastic resin and a basalt fiber as a reinforcement, wherein the basalt fiber is surface-treated with an alkoxy-group-substituted silane compound.

Abstract: An anti-agglomeration device for a nanofluid includes a support module, a motion module, a photoacoustic conversion module and a control module. The support module includes a frame and screws and is configured to support the photoacoustic conversion module and the motion module. The photoacoustic conversion module includes a nanosecond laser, a first clamp, a lens, a silica optical fiber, a second clamp, gold nanoparticles and a container and is configured to realize photoacoustic conversion to generate ultrasonic waves. The motion module includes a servo motor, a dovetailed rail, a guide screw, a fixed plate, a slider and a deep groove ball bearing. The motion module is configured to support the photoacoustic conversion module and realize the combined motions of the photoacoustic conversion module. The control module includes a support plate and a CCD camera and is configured to control the motion module in real time.

Abstract: A concrete vibrator can automatically change the rotational speed of a motor depending on the state of a vibrating tube. Under control by a controller, the concrete vibrator is operated in a normal mode in which the motor is supplied with driving power having a frequency to make the motor rotate at a rotational speed suitable for air bubble removal, or in an idling mode in which the motor is supplied with driving power having a frequency to make the motor rotate at a lower rotational speed than in the normal mode. The controller measures, per unit of time, a value of a current that is input to the controller or motor, compares a latest current value to a reference value calculated based on a past measurement value, and compares an absolute value of the comparison value to a threshold to grasp the state of the vibrating tube.

Abstract: A computer-implemented method according to one embodiment includes identifying a textual document, determining chemical data within the textual document, performing an analysis of the chemical data, and determining whether the chemical data is associated with one or more dangerous characteristics, in response to the analysis.

Abstract: Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.

Abstract: A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate, wherein the co-jet milled glycopyrrolate and magnesium stearate is then subjected to a conditioning step which includes exposure of the co-jet milled glycopyrrolate and magnesium stearate to humidity. A composition made by this method is also disclosed.

Abstract: Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

Abstract: The invention relates to a device (1) and a method, comprising a workpiece-receiving portion (2) for receiving a workpiece (28) to be mechanically machined. At least one vibrating device (9) is connected to the workpiece-receiving portion (2), and the vibrating device (9) causes the workpiece-receiving portion (2) to vibrate, the vibration of the workpiece-receiving portion (2) having a frequency that is lower than the frequency of ultrasound. The vibrating device (9) has a vibrating body (8) to which a compensating mass (7) that vibrates in the opposite direction is associated.

Abstract: An apparatus for pre-stressing a component, the apparatus includes means to direct a beam of radiation in a path through a medium adjacent to the component between a pair of electrodes to produce ionisation in the path through the medium and means to produce an electrical discharge between the pair of electrodes in the path through the medium to produce a pressure pulse in the medium adjacent to the component without the electrical discharge directly contacting the component, the pressure pulse impacting a surface of the component to produce a region of compressive residual stress within the component.

Abstract: An ionic liquid can disperse graphene at a high concentration. The ionic liquid can be represented by general formula (1): in which R1 and R5 may be the same or different and each independently represents a substituted or unsubstituted C1-7 linear or branched alkyl group; R2 is represented by formula (2): in which R6 and R7 may be the same or different and each independently represents a C1-4 linear or branched alkylene group, and m represents an integer of 1-5; R3 and R4 may be the same or different and each independently represent a hydrogen atom, substituted or unsubstituted C1-4 linear or branched alkyl group; X? represents a counter ion; and n represents 0-30.

Abstract: Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.

Abstract: Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber.

Abstract: A method and system for ultrasonically and simultaneously induced cavitation processing of fluid media-filled cells is provided. The method and system requires placing of cells in a bath filled with process fluid, wherein the fluid cell material exhibits specific acoustic resistance to be equal or close to that of the process fluid, sufficient acoustic wave amplitude is produced for specific process fluid so that well-developed acoustic cavitation occurs in process fluid and within every cell exposed to processing. The process fluid bath structure has a rectangular form where an acoustic standing wave is produced in the process fluid and is reflected from the bath walls and bottom. These walls and bottom may be designed as elastic membranes to have a self-resonant first harmonic frequency.

Abstract: An apparatus and a method for treating fluids with ultrasound are provided. In order to achieve a desired effect of the treatment as efficiently as possible, the apparatus has a plurality of inlet openings for the fluids and the fluids to be brought into contact with one another while being exposed to ultrasound.

Abstract: A method is disclosed for making a pharmaceutical composition for pulmonary administration, the method comprising a step in which an inhalable pharmaceutically active material is acoustically blended in a resonant acoustic blender. The invention also relates to compositions for inhalation prepared by the method.

Abstract: A mechanism for generating an orbital motion for mixing, particularly for shaking, a fluidic sample (38) accommodated by a sample holder (14, 40), wherein the mechanism comprises a stationary mounted or lockable first cogwheel (2) having a first through hole (30) and a plurality of first cogs (80) arranged along an outer circumference of the first cogwheel (2), a movably mounted second cogwheel (4) having a second through hole (32) and a plurality of second cogs (82) arranged along an outer circumference of the second cogwheel (4), a drive shaft (3) having a concentric first section (34) and an eccentric second section (36), wherein the first section (34) is guided through the first through hole (30) and the second section (36) is guided through the second through hole (32), and a coupling body (5) having a plurality of third cogs (84) arranged along an inner circumference of the coupling body (5), wherein the coupling body (5) is mounted with the first cogwheel (2) and with the second cogwheel (4) to engage

Abstract: A method for preparing an insulating varnish. The method includes: providing equivalence of an epoxy resin solution having a concentration exceeding 99 wt. % and acetone solution having a concentration of 40 wt. %, adding silane coupling agent-modified hexagonal boron nitride (BN) having a particle size of between 200 and 250 nm to the acetone solution and stirring; mixing the epoxy resin solution and the acetone solution and stirring, and dispersing the resulting mixture; adding to the mixture, low molecular weight polyamide resins as a curing agent, and stirring to uniformly disperse the curing agent; adding n-butane as a lubricant to the mixture and stirring, cooling the mixture to room temperature, adding di-n-butyl phthalate as a diluent to the mixture and stirring; and allowing the mixture to stand in a vacuum drier to remove bubbles to yield the insulating varnish, which is free of bubbles.

Abstract: A system and method for controlling a mixing system at a peak energy efficiency point, maximum response point or reduced sound generation point based on displacement, velocity, acceleration or jerk operating conditions.

Abstract: A principal object of the present invention is to provide a pharmaceutical composition that can produce a high antitumor effect by efficiently delivering a drug with antitumor activity to tumor tissues with the aid of carbonate apatite nanoparticles. The present invention provides a pharmaceutical composition including carbonate apatite nanoparticles with an average particle size of at most 50 nm containing a drug with antitumor activity and a pharmacologically acceptable solvent in which the carbonate apatite nanoparticles containing the drug are dispersed.

Abstract: A process for manufacturing titanium dioxide pigment is provided. The process comprises preparing an aqueous slurry of titanium dioxide particles. The process further includes deagglomerating the aqueous slurry of titanium dioxide particles using ultrasonication.

Abstract: Novel systems and apparatuses for dispensing particulate media are disclosed. One such system may include a storage tank for storing media, a feed tube in communication with the tank, a mixing chamber in communication with the feed tube, a tank sensor to detect pressure within the storage tank, and a mixing chamber sensor to detect pressure within the mixing chamber, wherein the mixing chamber is preferably configured to receive media when the pressure within the storage tank is about equal to the pressure within the mixing chamber. A non-pressurizable vibrator is preferably mounted external to the feeder. The vibrator is configured to vibrate media received in the feed tube from the media tank substantially along the feed tube toward the mixing chamber. The media dispensing system may further comprise an accelerometer in communication the vibrator to provide feedback regarding vibration of the feed tube.

Abstract: Disclosed herein is a method for exfoliating a laminar material to form an exfoliated material, in which the laminar material is ultrasonicated in a solution of a surfactant for sufficient time to form the exfoliated material. At all times during the ultrasonication the concentration of the surfactant in the solution is maintained sufficient to form a complete monolayer on the surfaces of the laminar material and the exfoliated material in the solution, or sufficient to sterically stabilise the laminar and exfoliated materials against aggregation.

Abstract: Disclosed embodiments include a feedstock preparation system that includes a first slurry preparation system that may receive a first portion of a solid fuel to generate a first fuel slurry using the first portion of the solid fuel and a liquid and second slurry preparation system separate from the first slurry preparation system that may receive a second portion of the solid fuel and the first fuel slurry. The second slurry preparation system may produce a second fuel slurry using the second portion of the solid fuel and the first fuel slurry. The first fuel slurry has a first particle size distribution and the second fuel slurry has a second particle size distribution, and the first and second particle size distributions are different.

Abstract: Apparatuses and methods for generating a chemical gradient within a flow channel include providing at least one bubble support structure within the flow channel. A bubble support structure helps maintain a bubble at a predetermined location in flow channel when a fluid flow passes therethrough. Oscillations are induced in the bubble using acoustic waves, which may be provided by a piezoelectric transducer located proximate the flow channel. Two or more inlets provide fluids of different chemical compositions into the flow channel, and bubble oscillations are used to generate a dynamically controllable mixing process.

Abstract: A method and apparatus are provided for the controlled application of ultrasonic energy for conditioning of mixtures of gas and liquids by evolving and/or agglomerating gas bubbles existing with or in a liquid or for coalescing droplets of liquid dispersed in another liquid. The invention in preferred embodiments thereof comprises a coalescing apparatus for increasing the droplet size of a mixture formed as a liquid dispersed in another liquid, and a de-gassing apparatus arranged to evolve and/or agglomerate gaseous bubbles in a gas/liquid mixture. In the apparatuses, ultrasonic transducers are used to impart vibrational energy to the mixtures.

Abstract: Provided herein, are droplet mixture compositions and systems and methods for forming mixtures of droplets. The system may comprise two or more droplet generation units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The combined droplet populations can be mixed, heated, and collected for multiple uses, such as for use as calibration standards for instrument testing and analysis.

Abstract: An embodiment of the present disclosure provides a hand held pipette for aspirating and dispensing liquids including, a stirring device assembly, including a vibration inducing unit, a power source for the vibration inducing unit, and a control for the vibration inducing unit. Another embodiment of the present disclosure provides a microplate stirring device including, an orbital plate module having a proximal and distal side; at least one vibration inducing unit attached to the proximal side of said orbital plate module; and a base plate for receiving the microplate. Another embodiment of the present disclosure provides a liquid handling system used for aspirating and dispensing liquids including, a stirring module assembly. Another embodiment of the present disclosure provides a manual stirring device including, a vibration inducing unit; a power source for the vibration inducing unit; and a control for the vibration inducing unit.

Abstract: In a method of ultrasonically treating a substance disposed within a container an ultrasonic horn is positioned within the container with at least a portion of the horn submerged in the substance. The horn is ultrasonically excited to thereby ultrasonically energize the substance. An agitating member is rotated within the substance while the ultrasonic horn is excited to agitate the substance as the substance is ultrasonically energized.

Abstract: In one example, a method for producing a cutting device matrix includes mixing a plurality of constituent matrix materials using a resonant acoustic mixing process until the constituent matrix materials are substantially homogeneously distributed throughout the matrix.

Abstract: A universal dental impression material system uses a programmable device having containers for separately housing two or more components that form a dental impression material when mixed. A mixing chamber and a dispensing means respectively receive/mix the components and dispense the dental impression material. One or more viscosity modification zones are configured to apply viscosity manipulation to a component prior to mixing, to the components in the mixing chamber during mixing, and/or to the dental impression material in the dispensing means after mixing. A user interface accepts user input of desired properties, such as viscosity, color, work/set time and/or extrusion rate. A controller operatively coupled to the user interface is configured to control dispensing of the components to the mixing chamber, activation as needed of the viscosity modification zones, and dispensing from the dispensing means in response to the user input to achieve the desired properties.

Abstract: A drug container is arranged in a horizontal state where a central axis extends along a horizontal direction, and the drug container is rotated about the central axis. In such a way, a drug solution in the drug container is moved along an inner surface of the drug container, and the drug container is reciprocally vibrated along the central axis in a state where the drug container is rotated, to stir the drug solution.

Abstract: A mixing device includes a mixing section that mixes a liquid-phase fluid with one kind or two or more kinds among a solid, a gas, and a liquid-phase fluid different from the above-mentioned liquid-phase fluid, in which the mixing section includes a supply hole for a fluid, a discharge hole for the fluid, a flow path that makes the supply hole and the discharge hole communicate with each other, and a plurality of pins that protrudes from the flow path, and a fluid that includes materials to be mixed is supplied from the supply hole to the flow path, mixed by passing through the flow path with the contact with the pins, and discharged from the discharge hole.

Abstract: An apparatus and method for combining multiple materials. The multiple materials may include both a major material and one or more minor materials. The major and minor materials are added at transient or steady state flow rates, depending upon a command from a control signal. The actual flow rates track the commanded flow rates, but deviate by an error. The claimed arrangement provides an instantaneous and time-based error believed to be unobtainable in the prior art.

Abstract: A method and a device for taking a sample from a vessel are described. A section of a sample collector is set into a controlled oscillation, in order to monitor a change in the oscillatory behavior about contact of the sample collector with a liquid to be picked up or another component, and to achieve better thorough mixing of the sample by means of the oscillation.

Abstract: The invention relates to the field of cavitation treatment of liquid media as well as media, where the density of water or other liquid phase is over 65-70% of the total weight as well as to treatment of the objects placed in the treated liquid media. The method cavitation treatment consists of the vibration system with the liquid medium and the placed objects consisting of the wall-surfaces, each surface of the system is the membrane fixed outline. For example on a rigid frame, having a natural frequency with due consideration of the apparent mass of the vibration generator equal to the fundamental mode, the radiation of ultrasonic waves to the liquid media is carried out simultaneously by all membranes of the vibration system, providing in the treated media the effect of superposition of waves with forming a standing acoustic wave or multiple waves with different frequencies.

Abstract: A system for mixing a formation fluid sample obtained in a downhole sampling chamber. The system includes a mixing element disposed in the downhole sampling chamber. A support stand is operable to receive the downhole sampling chamber. A magnetic field generator is operably associated with the downhole sampling chamber such that when the magnetic field generator generates a magnetic field, the mixing element moves through the formation fluid sample responsive to the magnetic field, thereby mixing the formation fluid sample.

Abstract: The invention relates to a mixing element for a flowable substance, comprising a body enclosing a cavity, wherein the cavity has at least one opening and the cavity and the opening are located relative to the body such that a fluid flow of the flowable substance out of the cavity through the opening transfers a torque to the mixing element. The invention further relates to the use of a tube or hose section as such a mixing element and a mixing device comprising such a mixing element, a container, and a sound source coupled thereto for generating an oscillating pressure.

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.

Abstract: Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.

Abstract: Provided is a process for producing a dispersion liquid of carbon nanotube aggregates in which the carbon nanotube aggregates are dispersed in a dispersion medium, comprising the two steps: (A) a step of adsorbing a dispersant to carbon nanotube aggregates by physical dispersion treatment in a dispersion medium to prepare a carbon nanotube paste with a particle size of 100 nm to 20 ?m resulting from partial dissociation of a mass of the carbon nanotube aggregates; and (B) a step of dispersing the carbon nanotube paste by ultrasonic dispersion treatment. A process for producing a dispersion liquid of carbon nanotube aggregates with reduced destruction and breakage of graphite structure of a carbon nanotube aggregate can be provided.

Abstract: A stirring container in which liquid is contained is used in an analyzer for measuring a property of the liquid. The stirring container includes a recessed portion in which the liquid is held so that a meniscus is formed; and a sound wave generating unit disposed outside of a wall portion forming the recessed portion, and generates surface sound waves for stirring the liquid. The wall portion is configured so that a rising of the meniscus is lower than a rising of the meniscus formed by the liquid held in an assumed container whose cross section in a direction orthogonal to a depth direction of the recessed portion is the same as that of a circumscribed rectangle. The circumscribed rectangle is circumscribed about a portion, made of a same material as a part of the wall portion where the meniscus is formed, where the meniscus is formed in the relevant direction.

Abstract: Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.

Abstract: A method of mixing (10), including: providing a fluid (10) in a well (6) so as to establish an acoustic field gradient; and applying an acoustic signal to cause mixing within a fluid (3).

Abstract: The present invention is directed to a fluoropolymer tape having an electrically conductive surface. More specifically, the present invention is directed to a polytetrafluoroethylene (PTFE) tape and method for producing an electrically conductive tape by blending vapor-grown carbon fiber or carbon nanotubes or combinations of both with PTFE.

Abstract: This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.

Abstract: A filtration separation method for waste resin containing highly radioactive uranium powder and device thereof is mainly used for the waste resin after water treatment process in a nuclear facility. The uranium powder contained in the waste resin is highly radioactive. Thus, prior to the treatment of the waste resin, it is necessary to filter and separate the highly radioactive uranium powder to reduce the radioactivity. It is to put the uranium powder containing waste resin into an underwater holding tank and withdraw the waste resin by an underwater pump into a uranium powder filtration box. Then the uranium powder filtration box is lifted by a hoist to move to an underwater ultrasonic cleaner. High-pressure water flushing is applied and followed by underwater ultrasonic cleaning. Then the cleaning water (containing precipitated uranium powder) from the ultrasonic cleaner is drained to uranium powder collection device.

Abstract: In a method of treating a liquid, a liquid to be treated is introduced into a space, a mechanical cavitation element acts upon the liquid while gas is supplied into the region of the surface of the cavitation element and introduces the gas into the liquid by moving the cavitation element, and sound waves are introduced directly into the liquid by at least one acoustic power transducer.

Abstract: An agitating and mixing device 1 of the present invention includes a container 2 for storing the composition, an agitating member 3 for agitating the composition, which is inserted in the container 2, and a driving device 4 for vibrating the container 2. The agitating member 3 has a rod-like portion 32 having one end portion and another end portion, a plate-like portion 31 provided on the one end portion of the rod-like portion 32 and the grip portion 33 provided on the other end portion of the rod-like portion 33. The plate-like portion 31 is perpendicular to the rod-like portion 32. The agitating member 3 is configured to agitate the composition by spacing the plate-like portion 31 apart from the bottom surface of the container 2.