Calorimetry Patents (Class 374/31)
  • Patent number: 11673021
    Abstract: A device including a first flow channel, a second flow channel and a body part including an inner volume. A first space of the inner volume is adapted to be filled with liquid and a second space of the inner volume is arranged to receive steam. The device further includes means for conveying a gas flow from the steam space of the inner volume via the first flow channel to the outside of the device during inhalation and means for conveying the exhaled gas flow from the outside of the device via the second flow channel to the first space of the inner volume. The device further includes means for measuring a flow and a temperature of an airflow, and means for adjusting the flow of the airflow mechanically and/or automatically. The present disclosure further relates to a method and a system.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: June 13, 2023
    Assignee: WellO2 Oy
    Inventors: Ilpo Kuronen, Siamäk Naghian
  • Patent number: 11666920
    Abstract: A method of cleaning an aspiration tube in a specimen measuring apparatus includes: moving the aspiration tube while discharging a cleaning liquid onto an outer side surface of the aspiration tube; stopping the aspiration tube in a state where a tip of the aspiration tube or a droplet attached to the tip contacts a surface of a flow of the cleaning liquid; and moving the stopped aspiration tube in a direction away from the surface of the flow of the cleaning liquid.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 6, 2023
    Assignee: SYSMEX CORPORATION
    Inventors: Kota Misawa, Masaki Shiba, Hiroki Kotake
  • Patent number: 11650172
    Abstract: Provided herein is technology relating to measuring temperature and particularly, but not exclusively, to devices, methods, systems, and kits for doing measuring temperature at high resolution, e.g., in living organisms.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: May 16, 2023
    Assignee: The Regents of The University of Michigan
    Inventors: Pramod Reddy, Edgar Meyhofer, Anthony Fiorino, Dakotah Thompson, Chang Jiang, Rohith Mittapally, Sunghoon Hur
  • Patent number: 11499928
    Abstract: In an embodiment is provided a method for measuring a vapor-liquid transition of a substance, the method including introducing a substance into a sample cell of a calorimetric block of a differential scanning calorimeter (DSC) at a first initial pressure, the system volume being constant; maintaining the substance in a vapor phase; cooling the substance at a cooling rate; and generating a thermogram. In another embodiment is provided a method for measuring a vapor-liquid transition of a substance, the method including introducing a substance into a sample cell of a calorimetric block of a DSC at a first initial pressure, the system volume being constant; maintaining the substance in a liquid phase; heating the substance at a heating rate; and generating a thermogram. In another embodiment is provided a method for measuring a vapor-liquid transition of a substance in the presence of an adsorbent.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: November 15, 2022
    Assignee: University of Wyoming
    Inventors: Hertanto Adidharma, Sugata P. Tan, Morteza Dejam, Xingdong Qiu
  • Patent number: 11169582
    Abstract: An immersion cooling tank includes a tank body and a liquid flow tube. The tank body holds a coolant and an electronic device. The tank body defines an inlet and an outlet. The inlet and the outlet are respectively located at opposite ends of the electronic device for inputting and outputting the coolant. The coolant flows through the electronic device. The liquid flow tube includes at least one adjuster. The liquid flow tube is located inside the tank body and coupled to at least one of the inlet or the outlet. The at least one adjuster faces the electronic device for controlling an amount of the coolant flowing in or out of the tank body.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: November 9, 2021
    Assignee: HONGFUJIN PRECISION ELECTRONICS(TIANJIN)CO., LTD.
    Inventors: Tze-Chern Mao, Yen-Chun Fu, Chih-Hung Chang, Yao-Ting Chang, Li-Wen Chang, Chao-Ke Wei
  • Patent number: 11156507
    Abstract: Disclosed is a method for detecting a value which represents the temperature of a vibrating element of an ultrasonic transducer. The ultrasonic transducer has a resonant frequency (fr). The method comprises the steps of operating the ultrasonic transducer with an electric measuring signal at a measuring frequency (fm) which is above the resonant frequency, and of detecting the absolute value of the complex impedance of the ultrasonic transducer at this measuring frequency (fm) and, building thereon, ascertaining the desired value, which is to represent the temperature of a vibrating element of an ultrasonic transducer, as a function of the detected absolute value of the complex impedance of the ultrasonic transducer at this measuring frequency (fm).
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 26, 2021
    Assignee: ELMOS SEMICONDUCTOR SE
    Inventor: Egbert Spiegel
  • Patent number: 11097268
    Abstract: A device includes a microfluidic channel structure on a substrate with a first fluid actuator and a second fluid actuator within the microfluidic channel structure. One of the fluid actuators is selectively employable to at least partially reverse fluid flow within at least a portion of the microfluidic channel structure in response to a blockage or to prevent a blockage.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 24, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jeremy Sells, Nick McGuinness, Chantelle Domingue, Manish Giri
  • Patent number: 11047816
    Abstract: A method for measuring thermal diffusivity/conductivity of a microscale sample includes placing a metallic disk atop the sample, and disposing a nanomembrane over the sample and over the metallic disk so that the nanomembrane, so that the metallic disk, the nanomembrane and the sample are in thermal equilibrium with one another. A laser beam is directed to fall onto the nanomembrane over the sample, while a radiation sensor is operated to detect photoluminescent radiation emitted by the nanomembrane in response to the laser beam. A spectral shift in the detected photoluminescent radiation emitted by the nanomembrane is determined, and thermal diffusivity/conductivity is calculated from the determined spectral shift of the photoluminescence.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: June 29, 2021
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Rami Tarek El Afandy, Boon Siew Ooi
  • Patent number: 10921197
    Abstract: A method for microscale calorimeter chamber data manipulation and visualization includes receiving a dataset from a microscale calorimeter chamber. The dataset is indicative of heat release rates for a test material as a function of a temperature applied by the microscale calorimeter chamber to the test material. The method further includes generating a baseline for correcting the heat release rates for the test material based on a selected temperature interval of the dataset. The method also includes generating a modified dataset that includes modified heat release rate values for the test material based on the baseline. The method includes generating a graphical user interface and displaying, via the graphical user interface, a graphical depiction of the modified dataset.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: February 16, 2021
    Assignee: THE BOEING COMPANY
    Inventors: William R. Ferng, John N. Harris, Jeffrey C. Mentel, Gregory L. Hooker
  • Patent number: 10782421
    Abstract: A photonic calorimeter converts ionizing radiation dose to heat and includes: a radiation absorber, a temperature compensator disposed within the radiation absorber, a compensation waveguide, a compensation resonator, a compensation resonator, a thermal isolator on which the radiation absorber is disposed and that thermally isolates the radiation absorber from heat loss by thermal transfer due to physical contact by an object, and the temperature compensator changes the optical resonance of the compensation resonator in response to a change in temperature of the radiation absorber due to absorption of the ionizing radiation by the radiation absorber.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 22, 2020
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Ronald Tosh, Zeeshan Ahmed, Ryan P. Fitzgerald, Nikolai Klimov
  • Patent number: 10775858
    Abstract: A liquid immersion cooling tank includes a reservoir and a liquid flow tube. The reservoir contains an insulating coolant to immerse an electronic device. The liquid flow tube includes an adjusting member. The reservoir includes an inlet and an outlet. The inlet and the outlet are respectively arranged at opposite ends of the electronic device. The liquid flow tube is located inside the reservoir. The liquid flow tube is coupled to at least one of the inlet and the outlet. The adjusting member faces the electronic device to control an amount of inflow or outflow of the insulating coolant. When the electronic device is immersed in the reservoir for cooling, the insulating coolant flows through the electronic device. The liquid flow tube coupled to the inlet or the outlet of the reservoir uses the adjusting member to control the amount of inflow or outflow of the insulating coolant.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: September 15, 2020
    Assignee: HONGFUJIN PRECISION ELECTRONICS (TIANJIN) CO., LTD.
    Inventors: Tze-Chern Mao, Yen-Chun Fu, Chih-Hung Chang, Yao-Ting Chang, Li-Wen Chang, Chao-Ke Wei
  • Patent number: 10732080
    Abstract: In one aspect, a system for controlled temporal extraction of ingredients of a pharmaceutical dosage form is disclosed, which comprises at least one reservoir for storing a fluid comprising a solvent, a cell having at least one inlet port in fluid communication with said reservoir for receiving a flow of the fluid from the reservoir and an outlet port through which fluid can exit the cell, where the cell is configured to receive a pharmaceutical dosage form. The system can further include an in-line heater disposed in proximity of the inlet port of the cell for heating the fluid to an elevated temperature prior to entry thereof into the cell, and a pump for causing fluid circulation between said reservoir and said cell.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: August 4, 2020
    Assignee: SOTAX Corporation
    Inventors: Kevin Whitkanack, Philip Gauthier, Robert Houser, Tye Fowler, Ryan Kelly
  • Patent number: 10481115
    Abstract: A calorimeter with a heat sink that includes a diffusion-bonded block that has higher thermal conductivity laterally across the block than through the block. The diffusion-bonded block has multiple metallic layers that are diffusion-bonded together, with relatively higher thermal conductivity layers alternating with relatively lower thermal conductivity layers. The diffusion-bonded block may be used in differential scanning calorimeters, multi-cell differential scanning calorimeters, nano-differential scanning calorimeters and isothermal titration calorimeters, as well as other calorimeters that measure differential heat flow to and/or from a sample with respect to the heat flow to and/or from a reference.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 19, 2019
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Donald J. Russell, David Serrell
  • Patent number: 10422742
    Abstract: A method and system for an aerospace vehicle. A pulse of electromagnetic radiation is transmitted into the composite sandwich panel such that the composite sandwich panel is heated above an ambient temperature. An amount of infrared radiation generated in the composite sandwich panel is detected in response to transmitting the pulse of electromagnetic radiation into the composite sandwich panel using a time window selected to detect the amount of infrared radiation when the pulse of electromagnetic radiation heats the composite sandwich panel. The amount of infrared radiation detected indicates a level of moisture in the composite sandwich panel.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 24, 2019
    Assignee: The Boeing Company
    Inventors: Morteza Safai, Xiaoxi Wang
  • Patent number: 10413754
    Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: September 17, 2019
    Assignee: Sun Nuclear Corporation
    Inventors: Jan Seuntjens, Arman Sarfehnia, James Renaud
  • Patent number: 10408690
    Abstract: According to a manufacturing method of a heat flux sensor, the heat flux sensor is sandwiched between a heater plate and a cooling unit. The heater plate is disposed on the first surface of the heat flux sensor, and the cooling unit is disposed on the second surface of the same. A heat radiation measurement plate is disposed on a surface of the heater plate opposite to the surface on which the heat flux sensor is disposed. According to this configuration, the temperature of the heater plate is controlled in an inspection process such that the heater plate is kept at an ambient temperature. This makes it possible to stabilize the temperature of the heater plate in a short time.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: September 10, 2019
    Assignee: DENSO CORPORATION
    Inventors: Norio Gouko, Atusi Sakaida, Keiji Okamoto, Yoshihiko Shiraishi
  • Patent number: 10288497
    Abstract: Apparatus and methods are provided for providing flexible and repairable testing capabilities, including destructive testing, for systems that generate or absorb heat such as energy storage systems. One embodiment can include a temperature bath structure adapted to contain and maintain a fluid bath at a predetermined temperature, an outer containment structure adapted to insert into the temperature bath structure, heat sinks, thermal sensor assemblies, and an internal containment structure where the thermal sensor assemblies, heat sinks removeably attach to different sections of the inner containment structure so as to measure heat flow into or out of the inner containment structure's different sections, and a test cell enclosure which is adapted to contain forces and output from destructive testing of samples.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: May 14, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Ryan Ubelhor, Daniel Ellison, Cecilia Pierce
  • Patent number: 10201797
    Abstract: A reaction apparatus includes first and second reaction material accommodation parts, each of which accommodates a solid, gaseous, or liquid reaction material. A feed pump feeds the reaction material to one or each of the first and second accommodation parts. A reactor mixes the reaction material fed from the feed pump. The reactor is configured to have a cylinder that has a reaction chamber which accommodates the reaction material therein. The reactor has injection ports on which one side of each of the upper portion and lower portion thereof are connected to the first and second reaction material accommodation parts, respectively. A stirring shaft is disposed to be rotatable in the cylinder and stirs the reaction material supplied from the first and second reaction material accommodation parts. A stirring motor provides torque for the stirring shaft.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: February 12, 2019
    Assignees: LAMINAR CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Jong Pal Hong, Hee Wan Lee, Gyeong Rye Choi, Joong Won Lee, Ho Jeong Chae
  • Patent number: 10166542
    Abstract: A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 1, 2019
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Alexandra Ros, Bahige G. Abdallah
  • Patent number: 10001417
    Abstract: Apparatus and methods are provided for providing flexible and repairable testing capabilities for systems that generate or absorb heat such as energy storage systems. One embodiment can include a temperature bath structure adapted to contain and maintain a fluid bath at a predetermined temperature, an outer containment structure adapted to insert into the temperature bath structure, heat sinks, thermal sensor assemblies, and an internal containment structure where the thermal sensor assemblies and heat sinks removably attach to different sections of the inner containment structure so as to measure heat flow into or out of the inner containment structure's different sections. Embodiments of the invention enable rapid insertion/removal of samples as well as replacement of sections of the system including embodiments or parts of thermal sensor assemblies as well as enabling separate thermal measurements associated with different sections of a sample under test within the inner containment structure.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: June 19, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Ryan Ubelhor, Daniel Ellison, Cecilia Pierce
  • Patent number: 9895557
    Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 20, 2018
    Assignee: Sun Nuclear Corporation
    Inventors: Jan Seuntjens, Arman Sarfehnia, James Renaud
  • Patent number: 9739670
    Abstract: Apparatus and methods are provided for providing flexible and repairable testing capabilities for systems that generate or absorb heat such as energy storage systems. One embodiment can include a temperature bath structure adapted to contain and maintain a fluid bath at a predetermined temperature, an outer containment structure adapted to insert into the temperature bath structure, heat sinks, thermal sensor assemblies, and an internal containment structure where the thermal sensor assemblies and heat sinks removeably attach to different sections of the inner containment structure so as to measure heat flow into or out of the inner containment structure's different sections. Embodiments of the invention enable rapid insertion/removal of samples as well as replacement of sections of the system including embodiments or parts of thermal sensor assemblies as well as enabling separate thermal measurements associated with different sections of a sample under test within the inner containment structure.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: August 22, 2017
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Ryan Ubelhor, Daniel Ellison, Cecilia Pierce
  • Patent number: 9612229
    Abstract: A method for determining physical properties of combustion including: flowing a gas a critical nozzle and past a microthermal sensor wherein the mass flow of the gas through the critical nozzle is the same as the mass flow through the microthermal sensor; measuring the pressure drop in a reservoir of gas flowing to the nozzle; determining a first gas property factor based on the measured pressure drop; determining a second gas property factor based on a flow signal generated by the microthermal sensor; determining a thermal conductivity of the gas using the microthermal sensor; and determining a physical property of the combustion based on a correlation of the first and/or second gas property factors and the thermal conductivity.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: April 4, 2017
    Assignee: MEMS AG
    Inventors: Philippe Pretre, Andreas Kempe, Tobias Suter
  • Patent number: 9594039
    Abstract: A method for detecting an enthalpy change includes providing a first mixture and a second mixture to a drop generator. The first mixture includes a ligand. The second mixture contains a target molecule. The method further includes generating a drop in the drop generator. The drop includes the target molecule, a temperature-sensitive reporter compound, and the ligand. The method also includes measuring a property of the temperature-sensitive reporter compound in the drop to determine an amount of enthalpy change that has occurred.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: March 14, 2017
    Assignee: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: Michael I. Recht, Joerg Martini, Gregory L. Whiting, Francisco E. Torres
  • Patent number: 9586060
    Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: March 7, 2017
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Jan Seuntjens, Arman Sarfehnia, James Renaud
  • Patent number: 9501070
    Abstract: A method of controlling the temperature of a liquid held within a reaction container in a chamber of a thermal cycling apparatus, the method including determining a sensed chamber temperature from a temperature sensor in the chamber, determining an air temperature using the sensed chamber temperature, determining a liquid temperature using the air temperature and selectively heating or cooling air in the chamber in accordance with the liquid temperature.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: November 22, 2016
    Assignee: QIAGEN INSTRUMENTS AG
    Inventors: Steven N. Higginbotham, Warren Ludcke, Jason Austin
  • Patent number: 9459211
    Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: October 4, 2016
    Assignee: Nanotemper Technologies GmbH
    Inventors: Stefan Duhr, Philipp Baaske
  • Patent number: 9140504
    Abstract: A testing apparatus measures cooling power of an electrically-powered Microclimate Cooling Unit (MCU) at the point of use of the MCU. The tester includes fluid supply and return ports for fluidly connecting to the MCU. A fluid heater provides a heat load to fluid in the tester. Fluid temperatures upstream and downstream of the heater are measured. The fluid flow rate is adjustable and measurable. A digital processor extracts the temperature and fluid flow rate data and computes cooling watts. The computed cooling watts are compared to the manufacturer's specifications to determine if the MCU is operating properly.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 22, 2015
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Andrew Schultz, Adam Blot, Matthew Marsh, David Cassidy, Victor E. Nerses
  • Patent number: 9033574
    Abstract: A thermal analyzer (100) includes: a furnace tube (9) made of a transparent material; a heating furnace (3); a sample holding part (41, 42) arranged inside the furnace tube; a first support base (12); a second support base (14); a measurement chamber (30) connected to the furnace tube; a first movement part (22) for moving the first support base and the second support base between a measurement position, at which the furnace tube is connected to the measurement chamber, and a sample setting position, at which the sample holding part is exposed on a rear end side with respect to the furnace tube and the heating furnace; and a second movement part (24) for moving only the second support base to a sample observation position, at which the heating furnace is advanced and the furnace tube is exposed. Accordingly, the sample is observable from outside the exposed furnace tube.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: May 19, 2015
    Assignee: HITACHI HIGH-TECH SCIENCE CORPORATION
    Inventors: Kanji Nagasawa, Kentaro Yamada, Shinya Nishimura
  • Publication number: 20150108356
    Abstract: Radiotherapy is one of the most effective treatments for cancer and its success depends critically on accurate targeting and delivery of the correct radiation dose. Accurate dosimetry is therefore essential to maintain and improve patient survival rates. However, size and long wait times currently limit water and graphite based calorimeters to standards laboratories leaving field-based dosimetry to ionization chamber measurements which depend upon a reference field-specified calibration factor. It would therefore be beneficial to provide radiotherapy equipment operators a direct approach of clinical reference dosimetry wherein the dosimeter provides increased independence on dose, dose rate, radiation energy, and energy type, etc. It would be further beneficial for such novel clinical dosimeters to be compact, function as secondary standards used routinely for measurements and allow radiotherapy doses to be measured directly and in an absolute manner.
    Type: Application
    Filed: May 29, 2013
    Publication date: April 23, 2015
    Inventors: Jan Seuntjens, Arman Sarfehnia, James Renaud
  • Patent number: 9004752
    Abstract: A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 14, 2015
    Assignees: Abbvie, Inc., Abbvie Deutschland GmbH & Co KG, Wisconsin Alumni Research Foundation
    Inventors: Geoff G. Zhang, Lian Yu, Jing Tao, Ye Sun, Markus Maegerlein
  • Publication number: 20150092811
    Abstract: Coding systems may include an object and a taggant linked to the object, the taggant comprising one or more types of phase change nanoparticles, each type of phase change nanoparticles having a phase change temperature different from a phase change temperature of other types of phase change nanoparticles, wherein, when the taggant is thermally scanned, different phase change temperatures result in one or more predefined melting peaks forming a code that represents information particular to the object.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 2, 2015
    Inventor: Ming Su
  • Publication number: 20150055675
    Abstract: Methods to determine a quantitative composition of a multi-component medium are described. These methods provide for placing a sample into a cell of a differential scanning calorimeter and injecting a liquid into the cell, the liquid has a known volume thermal expansion coefficient and a known volume heat capacity. A total heat capacity and a total volume thermal expansion coefficient are determined for the sample and the fluid inside the cell. Solving system of equations it is possible to determine volumes of components composing the sample.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 26, 2015
    Inventor: EVGENY NIKOLAEVICH DYSHLYUK
  • Publication number: 20150036715
    Abstract: In order to determine a volume thermal expansion coefficient of a liquid, a sample of the liquid is placed inside a cell of a calorimeter followed by an incremental increase of pressure inside the cell containing the liquid. After each pressure increase heat flow into the cell and volume of the liquid are measured. Based on results of the measurements of the heat flow and accounting for initially evaluated cell volume, the volume thermal expansion of the liquid is determined.
    Type: Application
    Filed: June 30, 2014
    Publication date: February 5, 2015
    Inventors: Evgeny Nikolaevich Dyshlyuk, Albina Rishatovna Mutina, Simon Ivar Andersen, Kurt Schmidt
  • Publication number: 20150010038
    Abstract: Devices and corresponding methods can be provided to measure temperature and/or emissivity of a target. Emissivity of the target need not be known or assumed, and any temperature difference between a sensor and the target need not be zeroed or minimized. No particular bandpass filter is required. Devices can include one or two sensors viewing the same target as the target views different respective viewed temperatures. The respective viewed temperatures can be sensor temperatures, and a single sensor can be set to each of the respective viewed temperatures at different times. An analyzer can determine the temperature and/or emissivity of the target based on the respective viewed temperatures and on plural net heat fluxes detected by the sensors and corresponding to the respective viewed temperatures.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 8, 2015
    Applicant: Exergen Corporation
    Inventor: Jason N. Jarboe
  • Publication number: 20140366647
    Abstract: Waveguides and electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising waveguides fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. The devices include electromagnetic splitters, filters, and sensors.
    Type: Application
    Filed: September 17, 2012
    Publication date: December 18, 2014
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Paul J. Steinhardt, Marian Florescu, Salvatore Torquato
  • Patent number: 8899827
    Abstract: A thermal analysis apparatus and method, including a sample space with a sample carrier, and heating devices, and an inert gas. Flow devices generate an inert gas flow to the sample carrier. Getter devices and/or oxygen traps disposed in the inert gas flow remove residual oxygen.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: December 2, 2014
    Assignee: Netzsch-Gerätebau GmbH
    Inventors: Alexander Schindler, Juergen Blumm
  • Publication number: 20140307756
    Abstract: The invention relates to an apparatus and method for measuring calorie in a beverage. The apparatus comprises a chamber, an information obtaining unit, a concentration measuring unit, a processing unit and a display screen. The chamber is configured to contain the beverage. The information obtaining unit is configured to obtain beverage information indicating the volume or the weight of the beverage. The concentration measuring unit configured to measure the concentration of a predetermined substance in the beverage. The processing unit is configured to calculate the overall calorie according to the volume or the weight of the beverage and the measured concentration of the predetermined substance. The display screen is configured to display the overall calorie.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 16, 2014
    Inventors: Weizhong Chen, Bin Yin, Declan Patrick Kelly
  • Patent number: 8851744
    Abstract: A calibrator for calibrating a compatible heat transfer meter comprises a temperature controlled reference thermowell and a reference temperature sensor. The reference thermowell is similar in dimensions to thermowells usable for measuring inlet and outlet temperatures of a heat exchanger so that the reference temperature sensor is selectively insertable into any of the thermowells. The calibrator also comprises temperature measurement circuitry operable to generate a temperature reading from an output of the reference temperature sensor; and control circuitry operable to control the temperature of the reference thermowell.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: October 7, 2014
    Assignee: Onicon, Inc.
    Inventor: Murray F Feller
  • Publication number: 20140294038
    Abstract: A heat generation point detection method comprises: step of stabilizing an average temperature of a surface of an integrated circuit S; steps of applying a bias voltage of a low frequency to the integrated circuit S and acquiring a heat generation detection signal detected from the integrated circuit S in response thereto; steps of supplying a bias voltage of a high frequency and acquiring a heat generation detection signal detected in response thereto; steps of detecting a phase shift between the bias voltage of the low frequency and the heat generation detection signal and a phase shift between the bias voltage of the high frequency and the heat generation detection signal; and step of calculating a change rate of the phase shift against a square root of the frequency of the bias voltage, and obtaining depth information of the heat generation point from the change rate.
    Type: Application
    Filed: August 31, 2012
    Publication date: October 2, 2014
    Applicant: HAMAMATSU PHOTONICS K.K.
    Inventor: Tomonori Nakamura
  • Publication number: 20140294037
    Abstract: Examples are generally described that include monitoring an electrocaloric effect device. A varying voltage may he applied across an electrocaloric effect material. A capacitance change of the electrocaloric effect material at least in part responsive to the varying voltage may be measured. A temperature change of the electrocaloric effect material may be calculated based, at least in part, on the capacitance change.
    Type: Application
    Filed: June 12, 2014
    Publication date: October 2, 2014
    Inventor: Ezekiel Kruglick
  • Patent number: 8840300
    Abstract: Certain embodiments disclosed herein are directed to a sensor comprising a support member, a sample sensor coupled to the support member and comprising a sample support electrically coupled to a first set of interconnects, and a reference sensor coupled to the support member and comprising a ring coupled to a second set of interconnects, in which the ring is positioned adjacent to and surrounding at least a portion of the sample support of the sample sensor.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: September 23, 2014
    Assignees: Perkinelmer Health Sciences, Inc., Anatech B.V.
    Inventor: Martinus J. L. M. Wijffels
  • Patent number: 8827548
    Abstract: A microfluidic embedded nanoelectromechanical system (NEMs) force sensor provides an electrical readout. The force sensor contains a deformable member that is integrated with a strain sensor. The strain sensor converts a deformation of the deformable member into an electrical signal. A microfluidic channel encapsulates the force sensor, controls a fluidic environment around the force sensor, and improves the read out. In addition, a microfluidic embedded vacuum insulated biocalorimeter is provided. A calorimeter chamber contains a parylene membrane. Both sides of the chamber are under vacuum during measurement of a sample. A microfluidic cannel (built from parylene) is used to deliver a sample to the chamber. A thermopile, used as a thermometer is located between two layers of parylene.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: September 9, 2014
    Assignee: California Institute of Technology
    Inventors: Michael L. Roukes, Chung-Wah Fon, Wonhee Lee, Hongxing Tang, Blake Waters Axelrod, John Liang Tan
  • Publication number: 20140219311
    Abstract: An automatic pipette assembly for an isothermal titration micro calorimetry system, comprising a pipette housing, a syringe with a titration needle arranged to be inserted into a sample cell for supplying titrant, and a linear activator for driving a plunger in the syringe, the titration needle is rotatable with respect to the housing and is provided with a stirring paddle arranged to stir fluid in the sample cell, wherein the automatic pipette assembly comprises a stirring motor for driving the rotation of the titration needle. There is also provided an isothermal titration micro calorimetry system.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 7, 2014
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: VALERIAN PLOTNIKOV, ANDRZEJ ROCHALSKI
  • Publication number: 20140177669
    Abstract: A sample of a material is placed into a measuring cell of a calorimeter consisting of upper and the lower parts connected with each other by a movable detachable tight connection. The cell is equipped with two coaxially arranged tubes capable of independent connection to external devices. An outer tube is connected to the upper part of the cell and an inner tube is connected to the lower part of the cell via the movable detachable tight connection and is movable. At least once a contact of the sample with vapor of a liquid is provided and heat of adsorption is measured, then contact of the sample with the same or another liquid is provided and heat of wetting of the sample by the same or the other liquid is measured.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 26, 2014
    Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: EVGENY NIKOLAEVICH DYSHLYUK, VITALY ALEKSEEVICH BALDYGIN
  • Patent number: 8746966
    Abstract: A thermoanalytical instrument, and especially a differential scanning calorimeter, has first and second measurement positions, a heater and a temperature sensor associated with each of the measurement positions, and a controller. The controller, which has an associated means for setting a predetermined temperature program, controls a heating power of the first heater to cause the temperature measured at the first position to follow the temperature program. The controller also controls both heaters to eliminate any temperature difference between the measured first and second temperatures. The controller also provides a means for determining the lower of the measured first and second measured temperatures and applies additional power to the heater associated with that lower measured temperature.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: June 10, 2014
    Assignee: Mettler-Toledo AG
    Inventors: Ernst Van De Kerkhof, Paul Pieter Willem Van Grinsven
  • Patent number: 8740453
    Abstract: In one embodiment, a microcalorimeter system includes a first microfluidic channel coupling a calorimeter with a sample chamber. A second microfluidic channel couples the calorimeter with a waste chamber. An inertial pump includes a fluid actuator integrated asymmetrically within the first microfluidic channel, and the fluid actuator is capable of selective activation to pump fluid from the sample chamber to the calorimeter and from the calorimeter to the waste chamber through the first and second microfluidic channels, respectively.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: June 3, 2014
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Erik D. Torniainen, Pavel Kornilovich, Alexander Govyadinov, David P. Markel
  • Publication number: 20140140365
    Abstract: A sensor for differential calorimetric measurement including a thermometric cell and another cell, each cell including: a membrane of a low thermal conductivity material, having first and second surfaces; and a mechanism supporting the membrane, of a high thermal diffusivity coefficient material, in contact with the first surface of the membrane, the thermometric cell including at least two active thermometric elements located on the first surface of the membrane, the two cells configured to be assembled such that the second surfaces of the membranes of the cells are opposite one another, a sample and a reference used for taking measurement configured to be placed between the two membranes and directly in contact with the second surfaces, and at least one of the cells including a sealing mechanism opposite the first surface of the membrane, wherein a free space for a gas is arranged between the sealing mechanism and the membrane.
    Type: Application
    Filed: June 18, 2012
    Publication date: May 22, 2014
    Applicants: Setaram Instrumentation, Centre National de la Recherche Scientifique
    Inventors: Jean-Luc Garden, Gael Moiroux, Pierre Lachkar
  • Patent number: 8708556
    Abstract: A thermal analyzer heats and cools a sample placed inside a furnace for measuring a thermal characteristic of the sample during heating and cooling. The thermal analyzer has a multilayer structure for covering the furnace and its surroundings so as to isolate the furnace and its surroundings from an external environment. The multilayer structure includes a multilayer wall with two layers formed of a material having high thermal conductivity and heat dissipation property. The two layers are spaced apart from one another to provide therebetween an interlayer that contains a substance having a heat capacity substantially equal to a gas contained in the furnace so that heat transfer between the two layers is minimized.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: April 29, 2014
    Assignee: SII NanoTechnology
    Inventors: Kentaro Yamada, Shinya Nishimura, Hirohito Fujiwara
  • Patent number: 8696989
    Abstract: A calorimeter device includes various components located on a common substrate. A first (calorimeter) integrated chip device is located on the substrate. This first device has a first microfluidic channel that has first side and a second side. A first heat sensing circuit is located on the first side of the first channel and a second heat sensing circuit is located on the second side of the channel, opposite the first side and facing the first heat sensing circuit. A second integrated chip device is located on the substrate and proximal to the first device. The second device includes a second microfluidic channel having a third side and fourth side. A third heat sensing circuit is located on the third side of the second channel. A fourth heat sensing circuit is located on the fourth side of the channel, opposite the third side and facing the third heat sensing circuit.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: April 15, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior Univerity
    Inventors: Hesaam Esfandyarpour, Ronald W. Davis