Structure To Facilitate Analysis Of The Results Patents (Class 422/402)
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Patent number: 8383064Abstract: A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences, an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, wherein, each of the chambers contains less than 270 picograms of probe and the reagent reservoir has a volume less than 1000,000,000 cubic microns.Type: GrantFiled: June 1, 2011Date of Patent: February 26, 2013Assignee: Silverbrook Research Pty LtdInventors: Mehdi Azimi, Kia Silverbrook
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Patent number: 8364233Abstract: A biodevice is in an elongated form and has a conductive layer and an insulating layer stacked on a side surface of a shaft member at the center. A cylindrical hollow section is formed through the device, being connected to the exterior at a front end and extending from this front end axially. An electrode section is formed on an inner surface. A sensing substance such as enzyme may be placed at the electrode section to detect a current value corresponding to the concentration or quantity of an object under test placed between a counter electrode and the biodevice.Type: GrantFiled: February 8, 2007Date of Patent: January 29, 2013Assignee: The University of TokushimaInventors: Mikito Yasuzawa, Shinya Furukawa
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Patent number: 8361394Abstract: A calibration system characterizes luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems. The calibration system has a baseplate with at least one flow-through channel, wherein the at least one channel is formed as a sample chamber for the luminescence measurement system, at least one reservoir in communication with the at least one channel and adapted to receive a liquid, and at least one focusing device integrated into a baseplate for setting a defined measurement beam focus of the luminescence measurement system to be calibrated by using a focusing surface.Type: GrantFiled: March 17, 2006Date of Patent: January 29, 2013Assignees: Bam Bundesanstalf Fuer Materialforschung und - Pruefung, Sigma-Aldrich GmbHInventors: Ute Resch-Genger, Katrin Hoffmann, Dietmar Pfeifer, Roland Nitschke, Pierre Nording
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Patent number: 8348843Abstract: A meter is provided that includes an improved user interface that enables the user to take a specific action, leading them directly to data input options. Such a user interface could be used to input first selected information, such as whether a test was premeal or postmeal, immediately after receiving a result. Optionally, the user interface may include the ability to add an additional comment after inputting the first selected information. Provision of such a user interface would facilitate simpler capture of the first selected information each time the user performs a test, leading to an enhanced understanding of a patient's level of glycemic control. Designing a user interface to enable first selected information to be entered by a user directly after receiving a result is more likely to engage a patient by making it easy and simple to enter important information. This may enable capture of the information thought to be most pertinent e.g.Type: GrantFiled: July 7, 2011Date of Patent: January 8, 2013Assignee: LifeScan Scotland LimitedInventors: Stanley Alan Young, David William Taylor, Allan Orr, Cheryl Neary, Nicola Canning, Marc Daniel Stern
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Patent number: 8343439Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: GrantFiled: June 20, 2007Date of Patent: January 1, 2013Assignee: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Patent number: 8327726Abstract: A microfluidic device includes a sample chamber accommodating a sample, a first sample distribution unit connected to the sample chamber and receiving the sample, a sample transfer unit connected to the first sample distribution unit and forming a path for transferring the sample, and including a first connection unit connected to the first sample distribution unit and a second connection unit, wherein the distance from the center of rotation to the second connection unit is greater than the distance from the center of rotation to the first connection unit, a second sample distribution unit connected to the second connection unit and receiving the sample transferred via the sample transfer unit after filling the first sample distribution unit, and first and second analysis units respectively connected to the first and second sample distribution units and analyzing ingredients of the sample.Type: GrantFiled: August 20, 2009Date of Patent: December 11, 2012Assignee: Samsung Electronics Co., Ltd.Inventors: Dogyoon Kim, Yoonkyoung Cho, Hansang Kim, Yangui Lee
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Patent number: 8328719Abstract: A meter is provided that includes an improved user interface that enables the user to take a specific action, leading them directly to data input options. Such a user interface could be used to input first selected information, such as whether a test was premeal or postmeal, immediately after receiving a result. Optionally, the user interface may include the ability to add an additional comment after inputting the first selected information. Provision of such a user interface would facilitate simpler capture of the first selected information each time the user performs a test, leading to an enhanced understanding of a patient's level of glycemic control. Designing a user interface to enable first selected information to be entered by a user directly after receiving a result is more likely to engage a patient by making it easy and simple to enter important information. This may enable capture of the information thought to be most pertinent e.g.Type: GrantFiled: July 7, 2011Date of Patent: December 11, 2012Assignee: LifeScan Scotland LimitedInventors: Stanley Alan Young, David William Taylor, Allan Orr, Cheryl Neary, Nicola Canning, Marc Daniel Stern
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Patent number: 8323566Abstract: A liquid sample analysis device includes a holder part 11 holding a test piece 1, an optical system 20 that optically detects a reaction state of a liquid sample and a reagent, and a support member 30 that integrally supports the holder part 11 and the optical system 20. The orientation of the test piece 1 is changed with respect to the direction of gravitational force by rotating the support member 30.Type: GrantFiled: July 28, 2009Date of Patent: December 4, 2012Assignee: Panasonic CorporationInventors: Kenji Murakami, Masahiro Aga, Hideyuki Kurokawa, Takahiko Tanida, Ryosuke Yamada
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Patent number: 8323583Abstract: A detection device and a detection method are disclosed. The detection device comprises a sample inlet (132) that allows liquid samples flowing from a collection chamber (20) to a detection chamber (10), which comprises a through hole (135) that allows gases circulation between the detection chamber and the collection chamber, and a sheath (140) that prevents liquid samples from entering into the detection chamber from the collection chamber via the through hole. The detection chamber contains test reagent strips (120) to detect whether samples contain interested analytes. The detection device further comprises a protrusion (131) that enables the detection device standing tilted in the traverse direction. The detection method comprises collecting liquid samples as the first step, followed by standing the device tilted in its traverse direction through a protrusion support, and detecting whether samples contain the analytes.Type: GrantFiled: January 5, 2010Date of Patent: December 4, 2012Assignee: Alere Switzerland GmbHInventors: Lijian Gou, Haipeng Hu
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Patent number: 8309024Abstract: A system for non-destructive determination of the degree of fluorination in carbon monofluoride (CFx) during the process of CFx synthesis is described. The system includes a measuring generator containing a capacitive sensor for measuring a respective capacitance, a base generator containing a capacitive sensor for measuring a base capacitance, and a processor for determining a difference between the respective capacitance and the base capacitance. The system is configured to determine the degree of fluorination based on the difference between the respective capacitance and the base capacitance.Type: GrantFiled: April 23, 2009Date of Patent: November 13, 2012Assignee: Enerize CorporationInventors: Volodymyr I Redko, Elena M Shembel, Volodymyr S Khandetskyy, Dayal T Meshri, Isaac A Angres, Robert Adams, Dmytro Sivtsov, Oxana V Redko, Tymofiy V Pastushkin
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Patent number: 8304255Abstract: The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound.Type: GrantFiled: February 11, 2009Date of Patent: November 6, 2012Assignee: Access Medical Systems, Ltd.Inventors: Robert F. Zuk, Hong Tan
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Patent number: 8303895Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.Type: GrantFiled: November 25, 2008Date of Patent: November 6, 2012Assignee: CapheidInventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
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Patent number: 8298495Abstract: The present invention relates to a high sensitivity localized surface plasmon resonance sensor and to a sensor system using same, the sensor comprising: a first metal layer including a first metal; a second metal layer arranged parallel to the first metal layer and including a second metal; and a conductive cross-linking layer disposed between the first metal layer and the second metal layer, and made of a third metal with a corrosion response that is different than that of the first metal and of the second metal.Type: GrantFiled: December 22, 2011Date of Patent: October 30, 2012Assignee: Korea Institute of Science and TechnologyInventors: Kyeong Seok Lee, Won Mok Kim, Taek Sung Lee
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Patent number: 8298497Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.Type: GrantFiled: December 14, 2009Date of Patent: October 30, 2012Assignee: The Secretary of State for DefenceInventor: David James Squirrell
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Patent number: 8293064Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.Type: GrantFiled: March 3, 2003Date of Patent: October 23, 2012Assignee: CepheidInventors: Ronald Chang, Douglas B. Dority
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Patent number: 8293178Abstract: A chemochromic sensor for detecting a combustible gas, such as hydrogen, includes a chemochromic pigment mechanically mixed with a polymer and formed into a rigid or pliable material. In a preferred embodiment, the chemochromic detector includes aerogel material. The detector is robust and easily modifiable for a variety of applications and environmental conditions, such as atmospheres of inert gas, hydrogen gas, or mixtures of gases, or in environments that have variable temperature, including high temperatures such as above 100° C. and low temperatures such as below ?196° C.Type: GrantFiled: November 6, 2007Date of Patent: October 23, 2012Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Luke B. Roberson, Janine E. Captain, Martha K. Williams, Trent M. Smith, LaNetra Clayton Tate
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Patent number: 8293188Abstract: In some embodiments, the present invention pertains to a method for detecting an adulterant in a biological sample. A combination of a biological sample, an agent for detecting the adulterant and an ionic moiety capable of undergoing reduction by gaining electrons is provided in an assay medium. The combination is incubated under conditions sufficient for the ionic moiety to undergo reduction and for the agent for detecting the adulterant to interact with the adulterant. The reduction of the ionic moiety enhances the detection of the adulterant as a result of increasing the sensitivity of the agent for detecting the adulterant. The extent of interaction between the agent for detecting the adulterant and the adulterant is measured and is related to the presence or absence of the adulterant in the biological sample.Type: GrantFiled: February 24, 2010Date of Patent: October 23, 2012Assignee: Siemens Healthcare Diagnostics, Inc.Inventors: Yuri Bukhtiyarov, Cathey M Briggs, Laura J Duggan
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Patent number: 8288170Abstract: The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.Type: GrantFiled: November 10, 2010Date of Patent: October 16, 2012Assignees: California Institute of Technology, University of Southern CaliforniaInventors: Yu-Chong Tai, Siyang Zheng, Henry Lin, Ram Datar, Richard Cote
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Patent number: 8282540Abstract: Methods for using a centrifuge are presented. A vessel containing a sample and a separator substance is placed within a centrifuge. Upon sufficient centrifugation, the sample separates into two or more fractions separated by the separator substance. The centrifuge exposes the separator substance to a sufficient energy to polymerize the separator substance to produce a hardened barrier between the fractions.Type: GrantFiled: June 28, 2010Date of Patent: October 9, 2012Assignee: The Regents of the University of CaliforniaInventor: Jane Emerson
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Patent number: 8277752Abstract: An optical measurement apparatus is provided for conducting a test by efficiently reading color development of a reagent after reaction by optical measurement. To the above end, an optical measurement apparatus is provided which is to be used with at least one test instrument mounted to the apparatus. The test instrument includes a carrier provided with at least one reagent retaining portion which retains a reagent, and a sample is applied to the carrier. The optical measurement apparatus includes a reader for reading color development of the reagent retaining portion, and a controller for performing driving control of the reader and determination. The controller performs the determination by utilizing data obtained by a reading operation P to read the color development of the reagent performed after the lapse of a reaction completion period Tr1-Tr6 from the mounting of the test instrument, and the reaction completion period depends on the reagent.Type: GrantFiled: November 20, 2008Date of Patent: October 2, 2012Assignee: ARKRAY, Inc.Inventors: Takashi Nakagawa, Shinya Nakajima, Tokuo Kasai, Kazuhiro Ohmiya
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Patent number: 8278110Abstract: A method and a blood oxygen tester for determining whether a blood sample is arterial or venous blood are disclosed. A blood oxygen tester for determining whether a blood sample is arterial or venous blood includes a housing and a blood sample receptacle defined by the housing. A blood oxygen sensor is in communication with the blood sample receptacle and a test result indicator is in communication with the blood oxygen sensor. The indicator is responsive to the blood oxygen sensor for indicating whether a tested blood sample is arterial blood or venous blood.Type: GrantFiled: November 1, 2011Date of Patent: October 2, 2012Inventor: Ali Ghobadi
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Patent number: 8262998Abstract: The invention describes a detection device that comprise nanostructures and which detection mechanism is based on the quantum confinement effects. The analyte species are sensed by measuring charge or/and energy transfer between the species and the nanostructures, which will be proportional to the overlap between the density of states distribution in the nanostructures and the density of states distribution in the targeted analyte species.Type: GrantFiled: April 15, 2005Date of Patent: September 11, 2012Inventors: Branislav Vlahovic, Vanja Vlahovic
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Patent number: 8262988Abstract: An antigen supply device 1 according to the present invention is mainly configured by a cylindrical member 3 extending in the vertical direction. An air suction port 5 for sucking the air in the antigen exposure chamber is provided at a lower end of the cylindrical member. An axial fan 6 that generates a flow of the air flowing upward in an axial direction of the cylindrical member is attached above the air suction port of the cylindrical member. Moreover, a supply port 4 through which high-concentration antigens are jetted from a dust feeder on the outside of the antigen exposure chamber is provided above the axial fan of the cylindrical member.Type: GrantFiled: September 28, 2005Date of Patent: September 11, 2012Assignee: Shinryo CorporationInventors: Huaipeng Tang, Akihiro Seta, Minoru Okuda, Kazuhiro Hashigucci, Kimihiro Okubo
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Patent number: 8257653Abstract: A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present in a sample of body fluid, when the test strip is positioned in the receptacle and the body fluid is placed on a test strip, and communicate the glucose amount to the hand-held computer via the connector portion.Type: GrantFiled: May 7, 2010Date of Patent: September 4, 2012Assignee: Abbott Diabetes Care Inc.Inventors: Steven Drucker, Charles T. Liamos, Fredric C. Colman, Mark Lortz, Kelley Lipman, Feng Jiang, Henrik Bacho
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Patent number: 8252602Abstract: The system and method for explosives detection may be used for detecting the presence of explosive elements. A testing device may have a case with a cover. A sample holder may be disposed in the case for receipt of a sample element and may have a sample retainer. The sample element may have a swipe pad attached to a backing element a heater may be disposed in the sample holder wherein the heater may be below the swipe pad adjacent the backing element when the sample element may be positioned in the sample holder. The heater may be in communication with an electric power source. The case may have a plurality of cavities formed therein for receipt of a plurality of fluid containers. The plurality of fluid containers may have at least a first reagent fluid and a second reagent fluid.Type: GrantFiled: November 7, 2003Date of Patent: August 28, 2012Inventor: Jeffrey S. Haas
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Patent number: 8247233Abstract: An integrated meter system for determining information related to an analyte of a fluid sample includes a meter including a housing and a plurality of test sensors. Each of the plurality of test sensors includes a penetrating member, a testing portion, and a channel. The channel is adapted to receive the fluid sample. The test sensors are removably located within the housing. At least one of the test sensors is removably connected to an adjacent test sensor. The integrated meter system also includes a test-sensor advancement mechanism that is configured to advance the test sensors.Type: GrantFiled: December 9, 2008Date of Patent: August 21, 2012Assignee: Bayer Healthcare LLCInventors: Igor Gofman, Mitchel Stein
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Patent number: 8241575Abstract: A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator, said displacement molecule being selectively removed from the molecularly imprinted crosslinked polymer and replaced with the taggant molecular structure upon exposure to the fluid containing the taggant molecular structure therein, thereby indicating the presence of the taggant molecular structure in the fluid.Type: GrantFiled: January 27, 2009Date of Patent: August 14, 2012Assignee: The Johns Hopkins UniversityInventors: George M. Murray, Andrew F. Mason, Edward W. Ott, Jr.
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Patent number: 8241572Abstract: An apparatus for analyzing biologic fluid is provided that includes first and second planar members, and at least three separators. At least one of the first planar member and second planar member is transparent. The separators are disposed between the planar members, and each individually has a height. The separators collectively having a mean height, and separate the planar members to form a chamber having a height extending between the planar members. At least one of the first planar member, second planar member, or separators is sufficiently deformable when the first planar member and second planar member are drawn toward each other by capillary force from a biologic fluid quiescently residing within the chamber to cause the mean chamber height to be substantially equal to the mean height of the separators.Type: GrantFiled: August 10, 2011Date of Patent: August 14, 2012Assignee: Abbott Point of Care, Inc.Inventor: Stephen C. Wardlaw
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Patent number: 8231839Abstract: The present invention provides a colorimetric gas detector comprising a substrate bearing a material that can react with a gas in an atmosphere being monitored and wherein the reaction causes the material to change the radiation at which the material absorbs or radiates radiation (the color-change material). The material is located in at least one discrete area of the substrate. By providing the color change material in discrete areas, the amount of such material can be reduced and different types of color-change material can be included on a common substrate to detect two or more gases simultaneously.Type: GrantFiled: October 7, 2005Date of Patent: July 31, 2012Assignee: Life Safety Distribution AGInventor: Ian Robins
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Patent number: 8226904Abstract: Formats for optical analysis of fluid samples are provided with platforms and wells for contacting fluid samples and bringing reagents in contact with fluid samples. Formats may be made in opposing platform-and-well constructions, allowing a platform protruding from one format member to enter a well contained within an opposing format member. A sample fill nose accepts sample fluid from a sample collection opening and transports the sample fluid through the format.Type: GrantFiled: October 29, 2004Date of Patent: July 24, 2012Assignee: Bayer Healthcare LLCInventor: Andrew J. Dosmann
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Patent number: 8221335Abstract: A blood test apparatus has a housing with an opening, and a plunger that moves back and forth inside the housing, the plunger having a projecting member. A fixing member fixes the plunger, which is provided in the housing. A blood sampling cartridge, in which a blood sensor, a puncturer, and a holder that holds the blood sensor and the puncturer, are integrated. The blood sampling cartridge is removably attached to the opening. The puncturer includes a lancet, one end of which is held by the plunger, and a blood collection needle attached to an other end of the lancet. A measuring circuit measures a signal obtained from the blood sensor to analyze components in the blood.Type: GrantFiled: June 29, 2011Date of Patent: July 17, 2012Assignee: Panasonic CorporationInventors: Yoshinori Amano, Masaki Fujiwara
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Patent number: 8211365Abstract: An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.Type: GrantFiled: October 11, 2011Date of Patent: July 3, 2012Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Joseph M. Chiapperi, Mary Kay Golisano
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Patent number: 8211382Abstract: Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.Type: GrantFiled: September 22, 2009Date of Patent: July 3, 2012Assignee: Wasatch Microfluidics, LLCInventors: David Myszka, Bruce Kent Gale, Joshua Wayne Eckman, Sriram Natarajan
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Patent number: 8206649Abstract: A component measuring apparatus is provided with a case having a cylindrical case main body and a cover arranged to cover the base end opening section of the case main body; a chip mounting section for mounting a chip; a light measuring section for detecting a prescribed component; a printed board whereupon a control section having a function of controlling the operation of the light measuring section is arranged; a liquid crystal display device; a battery arranging section for arranging a battery provided on the cover; an O-ring arranged between the case main body and the light measuring section on the leading end section of the case main body; and an O-ring arranged between the case main body and the cover on the base end opening section of the case main body. Sealing of inside the case is ensured by the O-ring.Type: GrantFiled: January 8, 2008Date of Patent: June 26, 2012Assignees: Terumo Kabushiki Kaisha, Hosiden CorporationInventors: Yoshiro Suzuki, Yasushi Nagasawa, Eiji Arita, Masakazu Ishizu, Yasuhiro Yamamoto
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Patent number: 8206992Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread.Type: GrantFiled: March 27, 2009Date of Patent: June 26, 2012Assignee: President and Fellows of Harvard CollegeInventors: Meital Reches, Michael D. Dickey, Manish J. Butte, George M. Whitesides
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Patent number: 8202488Abstract: A system for analyzing the concentration of an analyte in a fluid sample comprises a test strip and a meter. The test strip is capable of being inoculated by the fluid sample. The test strip includes a test element, which contains at least one reagent adapted to cause a reaction when brought into contact with the analyte. The meter includes a read-head, a repositioning device, and a display. The read-head is capable of producing a signal indicative of the reaction between the analyte and the at least one reagent. The display being capable of displaying the analyte concentration. The repositioning device is adapted to move the test strip from a loading position to a testing position. The testing position positions the test element proximate to the read-head.Type: GrantFiled: September 19, 2005Date of Patent: June 19, 2012Assignee: Bayer HealthCare LLCInventors: Sung-Kwon Jung, Steven C. Charlton
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Patent number: 8197775Abstract: The present invention provides a detection article including at least one fluid control film layer having at least one microstructured major surface with a plurality of microchannels therein. The microchannels are configured for uninterrupted fluid flow of a fluid sample throughout the article. The film layer includes an acquisition zone for drawing the fluid sample into the plurality of microchannels at least by spontaneous fluid transport. The film layer also includes a detection zone having at least one detection element that facilitates detection of a characteristic of the fluid sample within at least one microchannel of the detection zone. The detection article may be formed from a plurality of film layers that are stacked to form a three-dimensional article.Type: GrantFiled: May 22, 2007Date of Patent: June 12, 2012Assignee: 3M Innovative Properties CompanyInventors: Raymond P. Johnston, Patrick R. Fleming, Koichi Sano
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Patent number: 8183059Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.Type: GrantFiled: August 30, 2011Date of Patent: May 22, 2012Assignee: Invisible Sentinel, Inc.Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
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Patent number: 8182762Abstract: A vial and particles for distributing reagent bound particles in a fluid, a kit, and methods for distributing particles in a fluid.Type: GrantFiled: January 14, 2008Date of Patent: May 22, 2012Assignee: Biokit, S.A.Inventor: Joan Francesc Guasch
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Patent number: 8178056Abstract: There is provided a biochemical reaction cartridge comprising at least one chemical reaction chamber that accommodates a solution for biochemically treating a sample, a reaction chamber for performing detection reaction of a target substance in the biochemically treated sample, and a detection reaction information fetching section for fetching information on whether or not the detection reaction is performed, wherein the biochemical reaction cartridge is provided with a covering unit that can cover and expose at least the reaction information fetching section.Type: GrantFiled: November 1, 2005Date of Patent: May 15, 2012Assignee: Canon Kabushiki KaishaInventor: Daisuke Yokoyama
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Publication number: 20120106811Abstract: A biological material test strip and adjacently-located reference color chart are affixed to a lid portion of an all-in-one specimen cup to perform color-based reaction testing of collected biological specimens in an uncalibrated environment. After specimen collection, the lid portion is secured to a container portion of the specimen cup. The cup may then be rotated into an upside down position causing the specimen, under the force of gravity, to pass from the container portion and into a volume of the lid portion, such that the test strip is exposed to the specimen as it is received into the volume of the lid portion. An image of the exposed test strip and adjacently-located reference color chart may then be captured and processed to identify any color matches between the individual test pads on the test strip and the corresponding sequences of reference color blocks on the reference chart.Type: ApplicationFiled: November 3, 2011Publication date: May 3, 2012Applicant: TECO DIAGNOSTICSInventors: STEPHEN L CHEN, KC CHEN, NEERAJ KAPOOR
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Patent number: 8168442Abstract: A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.Type: GrantFiled: September 29, 2004Date of Patent: May 1, 2012Assignee: CepheidInventors: Kurt E. Petersen, William A. McMillan, Farzad Pourahmadi, Ronald Chang, Douglas B. Dority
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Patent number: 8161997Abstract: The present invention relates to a multipurpose flow module comprising flow plates and/or heat exchanger plates stacked together, which flow plate having a flow channel and one or more connection ports. To each flow plate or heat exchanger plate one or more barrier plates may be attached. The present invention further relates to a method for extraction, for reaction, for mixing, or combinations thereof in the multipurpose flow module, and to uses of the multipurpose flow module.Type: GrantFiled: October 18, 2006Date of Patent: April 24, 2012Assignee: Alfa Laval Corporate ABInventors: Kasper Höglund, Tommy Noren, Barry Johnson, Erik Cardelius
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Patent number: 8163253Abstract: A tamper-proof, point-of-collection specimen assay apparatus including three selectively connectable and sealable chambers, including a first chamber for receiving a specimen, a second chamber housing a specimen testing device and a specimen transfer site positioned between the first chamber and the second chamber for selectively depositing a portion of the specimen from the first chamber into the second chamber and a third chamber having inlets for depositing another portion of the specimen from the first chamber into the third chamber.Type: GrantFiled: July 15, 2008Date of Patent: April 24, 2012Inventor: R. Lawrence Hartselle
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Patent number: 8158078Abstract: Embodiments of the present invention relate to a test strip container which provides easy access to test strips. The test strip container includes a lower housing, an upper housing, and a retaining member configured to releasably retain the test strips in a nested configuration. The nested configuration of the test strip container provides easy access to test strips by arranging the test strips so that they extend radially outward from the retaining member. The radial arrangement of the test strips operates to separate the test strips so that test strip users may easily select a single test strip from a plurality of test strips. Alternatively, the test strip container includes a lower housing, an upper housing, and a retaining member configured to releasably retain the test strips in a longitudinal configuration.Type: GrantFiled: October 21, 2011Date of Patent: April 17, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Frank A. Chan, Chris Wiegel
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Patent number: 8158079Abstract: Provided is a panel (3) for analysis having a chamber inside for transferring a sample liquid dispensed as a drop on an injection port (14). The injection port (14) is formed to protrude in a direction away from the chamber, a recessed section (12) is formed around the injection port (14), and the injection port (14) is arranged on the side of a rotating axis center (11) of a holding member (101) for the panel for analysis in an analyzer. Thus, even when a sample liquid is adhered around the injection port, contamination and shortage of the sample liquid can be prevented.Type: GrantFiled: June 27, 2007Date of Patent: April 17, 2012Assignee: Panasonic CorporationInventors: Hirofumi Sugimoto, Masaaki Kito, Masakazu Mori, Shinichi Ninomiya, Noriyuki Shinohara, Hiroshi Takano
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Publication number: 20120083044Abstract: An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period.Type: ApplicationFiled: December 14, 2010Publication date: April 5, 2012Inventors: Andy Sturman, Benedict Zin, Albert Nazareth, Henry Bell
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Patent number: 8145431Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.Type: GrantFiled: March 30, 2006Date of Patent: March 27, 2012Assignee: Advanced Medical Products GmbHInventors: Hans G. Kloepfer, Thomas Kloepfer, Jason Heim, Reinhard Hafellner
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Patent number: 8143063Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.Type: GrantFiled: July 16, 2010Date of Patent: March 27, 2012Assignee: Lawrence Livermore National Security, LLCInventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
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Patent number: RE43815Abstract: An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.Type: GrantFiled: November 21, 2011Date of Patent: November 20, 2012Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.Inventors: William F. Crismore, Nigel A. Surridge, Daniel R. McMinn