Well Plate Patents (Class 422/407)
  • Patent number: 8475716
    Abstract: An embodiment of the invention described herein is directed to a detection system utilizing at least one radiofrequency identification (RFID) sensor comprising: an RFID sensor comprising: a substrate; an antenna; a sensor material selected to be sensitive to one of chemical or biological environment; and a reader, wherein said reader is configured to measure a signal in the form of a complex impedance from said RFID tag wherein said signal comprises a plurality of frequencies and a frequency shift of the maximum of the imaginary part of the complex impedance, a frequency shift of the minimum of the imaginary part of the complex impedance, a frequency shift of the maximum of the real part of the complex impedance, and changes in magnitude of the real part of the complex impedance; and, wherein said complex impedance is related to a nature and a concentration of analyte species derived from multivariate analysis.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: July 2, 2013
    Assignee: General Electric Company
    Inventors: Radislav Alexandrovich Potyrailo, William Guy Morris
  • Patent number: 8456626
    Abstract: The present invention is directed to a luminometer and methods which provides simple and effective measurement of a plurality of wells in a plurality of strips in an automatic fashion. The luminometer may be used in CLIA (Chemi Luminescent Immuno Assays). The luminometer allows for CLIA micro strip reading, and reads break-apart wells, with a plurality of wells per strip, and calculates results instantly and automatically. The luminometer has an automatic carrier positioning system which selectively positions the plurality of wells in the plurality of strips at a measuring position, wherein the drive system associated with the positioning system drives the carrier along a single axis of movement. An optical track system automatically provides Y axis movement of the carrier. The luminometer may have a calibration system for maintaining proper operation of the system in measurements therewith.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: June 4, 2013
    Assignee: Awareness Technology, Inc.
    Inventors: Gary Freeman, Valerie Almeter
  • Patent number: 8449833
    Abstract: The present invention provides a biosensor cartridge (11) comprising a bottom portion (1) with a well (2) adapted to accommodate a liquid sample and a cover portion (3) for closing said well (2). The well (2) has a sensor surface (4). The bottom portion (1) is adapted for allowing light to enter along a first optical path (5), to be reflected at the sensor surface (4) and to exit along a second optical path (6). The invention further relates to a method of manufacturing such a cartridge (11).
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: May 28, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventor: Jeroen Hans Nieuwenhuis
  • Patent number: 8449824
    Abstract: A sensor instrument system for detecting and identifying analytes in fluids of a region contains a local sensor instrument and remote central station. The instrument includes a core technology employing a single sensor having two electrodes operated by an electrical frequency sweeping to generate two sets of patterned electrical information from a single measurement, a data transmission module and a GPS receiver module. The central station connects to a network means connected to a plurality of local receiving sites equipped with including the respective transceivers, so that the local analyte electrical information and geographic position information transmitted by the instrument can be wirelessly and remotely received and processed by the central station.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: May 28, 2013
    Inventor: Yizhong Sun
  • Patent number: 8425840
    Abstract: A microchip comprising therein a first channel which allows inflow of a first liquid selected from whole blood, platelet-rich plasma and a drug-treated liquid thereof, a second channel connected to the first channel, which allows inflow of a second liquid containing an agent that is reactive with the first liquid, and a merged channel extended from the connection portion of the first channel with the second channel, wherein, in the merged channel, a stirring section having a stirring bar for mixing the first liquid with the second liquid is provided; and a blood monitoring device using the same.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: April 23, 2013
    Assignee: Fujimori Kogyo Co., Ltd.
    Inventors: Kazuya Hosokawa, Tomoko Wada
  • Patent number: 8420030
    Abstract: A well plate (1) for holding samples of a bodily fluid during analysis thereof, typically in an analytical apparatus, comprises a plate (2) having a plurality of first wells (3) extending downwardly therefrom for holding a sample during optical analysis of the sample, and a plurality of second wells (4) for holding samples during mechanical analysis of the samples. A plurality of holding wells (8) are provided for initially receiving and holding samples of the bodily fluid to be analysed so that samples of relatively accurate size can be pipetted from the holding wells (8) to the first and second wells (3,4).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Tcoag Ireland Limited
    Inventors: Ronan Patrick O'Caoimh, James Walsh, Brendan Kevin Farrell, Rory Peter Nealon, Josef Georg Hubert Wiehe
  • Patent number: 8398939
    Abstract: A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing configured for hand-held portability, the outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, a hybridization chamber mounted in the casing, the hybridization chamber containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the hybridization chamber has a volume less than 900,000 cubic microns.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 19, 2013
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Patent number: 8398940
    Abstract: A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, a detection photosensor for exposure to the photons emitted by the ECL luminophores, control circuitry providing the electrical pulse to the electrodes, and, a universal serial bus (USB) connection such that the outer casing is configured as a USB drive for transmitting data regarding detection of the targets in the fluid to an external device, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety do
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 19, 2013
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Kia Silverbrook, Alireza Moini, Mehdi Azimi
  • Patent number: 8394340
    Abstract: A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probe spots in contact with each of the electrode pairs respectively, the ECL probe spots containing ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the mass of the ECL probes in each of the probe spots is less than 270 picograms.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 12, 2013
    Assignee: Geneasys Pty Ltd
    Inventors: Kia Silverbrook, Mehdi Azimi
  • Patent number: 8394648
    Abstract: This invention relates to a method for the fabrication of photonic biosensor arrays and applications of arrays produced by the method in the biomedical field.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: March 12, 2013
    Assignee: Attomarker Limited
    Inventors: Andrew Mark Shaw, Rouslan Vladimir Olkhov
  • Patent number: 8389299
    Abstract: This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island comprising a plurality of metallic nanoparticles to which are attached functionalizing molecules for binding to a said biological target, different said islands bearing different said functionalizing molecules for binding to different ones of said biological targets, and wherein total internal reflection of light at said surface at a wavelength at or near a said plasmon resonance results in scattering of said light away from said surface, said scattering being modulated by said binding of said biological targets.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: March 5, 2013
    Assignee: Attomarker Limited
    Inventors: Andrew Mark Shaw, Rouslan Vladamir Olkhov, William Leslie Barnes
  • Patent number: 8388910
    Abstract: A portable test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing configured for hand-held portability, the outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 5, 2013
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Mehdi Azimi, Kia Silverbrook, Alireza Moini
  • Patent number: 8388893
    Abstract: A combined detector capable of simultaneously detecting both a value indicating a physical/chemical phenomenon such as a pH value and the intensity of an energy beam such as light. The combined detector comprises a physical/chemical phenomenon detecting system (10) and an energy beam detecting system. The physical/chemical phenomenon detecting system (10) has a sensing section (21) whose potential varies with a physical/chemical phenomenon, a charge supply section (22) for supplying first charge to the sensing section, a charge supply control section (23) provided between the sensing section (21) and the charge supply section (22), a first charge storage section (26) for storing the first charge transferred from the sensing section (21), and a charge transfer control section (27) provided between the sensing section (21) and the first charge storage section (26).
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: March 5, 2013
    Assignee: National University Corporation Toyohashi University of Technology
    Inventors: Kazuaki Sawada, Junichi Matsuo, Hirokazu Nakazawa
  • Patent number: 8383378
    Abstract: Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: February 26, 2013
    Assignee: The Regents of the University of California
    Inventors: Yuli Wang, Mark Bachman, Christopher E. Sims, Guann-Pyng Li, Nancy Allbritton
  • Patent number: 8383065
    Abstract: A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having a receptacle for receiving the fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, and, a detection photosensor for exposure to the photons emitted by the ECL luminophores.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: February 26, 2013
    Inventors: Alireza Moini, Mehdi Azimi, Kia Silverbrook
  • Patent number: 8377380
    Abstract: To provide a sensing device using a piezoelectric sensor having an oscillation area for detection and an oscillation area for reference and capable of achieving a high measurement sensitivity by improving shapes of excitation electrodes. On a quartz-crystal piece 20a, there are provided strip-shaped left side area and right side area which are formed symmetrically to be separated from each other into left and right with respect to a center of a circle 53 being a contour of a planar shape of a reaction channel 52 and extend in a longitudinal direction in a parallel manner.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: February 19, 2013
    Assignee: Nihon Dempa Kogyo Co., Ltd.
    Inventors: Tomoya Yorita, Shunichi Wakamatsu, Shigenori Watanabe, Takeru Mutoh
  • Patent number: 8372592
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: February 12, 2013
    Assignee: X-Body, Inc.
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • Patent number: 8367014
    Abstract: A sample block for use in the polymerase chain reaction, DNA sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the block is improved by the inclusion of hollows in the block that are positioned to decrease the mass of the block in the immediate vicinity of the wells.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: February 5, 2013
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Sunand Banerji
  • Patent number: 8361394
    Abstract: A calibration system characterizes luminescence measurement systems, in particular spectrally resolving, wide-field and/or confocal imaging systems. The calibration system has a baseplate with at least one flow-through channel, wherein the at least one channel is formed as a sample chamber for the luminescence measurement system, at least one reservoir in communication with the at least one channel and adapted to receive a liquid, and at least one focusing device integrated into a baseplate for setting a defined measurement beam focus of the luminescence measurement system to be calibrated by using a focusing surface.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: January 29, 2013
    Assignees: Bam Bundesanstalf Fuer Materialforschung und - Pruefung, Sigma-Aldrich GmbH
    Inventors: Ute Resch-Genger, Katrin Hoffmann, Dietmar Pfeifer, Roland Nitschke, Pierre Nording
  • Patent number: 8349277
    Abstract: A test module for concentrating pathogens in a biological sample, the test module having an outer casing with a receptacle for receiving the sample, a dialysis device in fluid communication with the receptacle and configured to separate the pathogens from other constituents in the sample, and, a lab-on-a-chip (LOC) device being in fluid communication with the dialysis device and configured to analyze the pathogens.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 8, 2013
    Assignee: Geneasys Pty Ltd
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Patent number: 8343778
    Abstract: The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and are sealingly connected to a test chip in consecutive steps. Each plate includes microfluidic channels configured in a predetermined reagent distribution pattern. The test chip comprises a plurality of discrete test positions, each test position being located at the intersection between a first predetermined reagent pattern and a second predetermined reagent pattern, wherein at least one of said patterns is non-linear. The first channel plate allows the distribution of a first reagent on said test chip, wherein said first reagent is immobilized at said test positions. The second channel plate allows the distribution of a second reagent on said test chip, wherein said second reagent comprises a plurality of different test samples.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: January 1, 2013
    Assignee: Simon Fraser University
    Inventors: Hua Zhong Yu, Meenakshinathan Parameswaren, Paul Chi Hang Li, Xing Yue Peng, Hong Chen, Wa Lok Chou
  • Publication number: 20120329170
    Abstract: An analyzing apparatus contains an image pickup unit and an analysis unit. The image pickup unit contains a view field area that covers at least a reaction area and a background area in a test piece. The reaction area exhibits a reaction color when exposed to a test substance in a specimen. The analysis unit detects the test substance based on the reaction color and determines, during detection of the test substance, whether a state of the background area falls within an acceptable range set for the test substance.
    Type: Application
    Filed: June 20, 2012
    Publication date: December 27, 2012
    Applicant: USHIO INC.
    Inventor: Shigeki Matsumoto
  • Patent number: 8338187
    Abstract: Methods and systems for venting a well that receives a liquid. The method includes providing a microplate including a well that has a cavity with an open inlet and a closed end. The cavity extends between the open inlet and the closed end. The cavity is defined by a wall surface having a cross-sectional contour that includes at least one continuous section and at least one discontinuity section. The method also includes depositing a liquid into the open inlet of the well. The liquid enters the cavity and flows toward the closed end to at least partially fill the well. The liquid flows along the continuous section of the wall surface and remains separated from the discontinuity section of the wall surface, thereby maintaining a gas exhaust path along a spacing between the liquid and the discontinuity section as the liquid flows toward the closed end.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: December 25, 2012
    Assignee: Illumina, Inc.
    Inventor: Chad F. DeRosier
  • Patent number: 8337785
    Abstract: A device (1) for housing a scientific sample comprising at least one sample well (2) and an on-board buffering substance (3) wherein the onboard buffering substance (3) at least partly surrounds the sample well (2). The on-board buffering substance (3) may be in the form of a matrix, such as a gel-like matrix. The device (1) may further comprise an insulating means. Also described is a substance for use in culturing and/or assaying a sample whereby the substance provides atmospheric and thermal buffering. The invention further provides a lid for a single-well or multi-well sample plate, the lid being configured to facilitate delivery of a sample through the lid into a well, and for sealing the well. The lid comprises moveable portions (52, 53) that have at least one orifice (54, 57) formed through the moveable portions (52, 53) such that a conduit is formed by alignment of the orifices (54, 57) of both the lid portions (52, 53).
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: December 25, 2012
    Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin
    Inventors: Anthony Davies, Slobhan Mitchell, Dermot Kelleher, Yuri Volkov
  • Patent number: 8323982
    Abstract: Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid that occurs in response to impingement of optical radiation upon the photoelectrocatalytic element. A semiconductor light emitting source is also provided that is configured to impinge the optical radiation upon the photoelectrocatalytic element. Related solid state devices and sensing methods are also described.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: December 4, 2012
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
  • Patent number: 8318099
    Abstract: Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: November 27, 2012
    Assignee: General Electric Company
    Inventors: Radislav Alexandrovich Potyrailo, William Guy Morris, Kenneth Brakeley Welles, II, Andrew Michael Leach, Andrew David Pris
  • Patent number: 8309035
    Abstract: A multi-well system is described which is comprised of a tray comprising a plurality of wells which may include thousands, tens of thousands or even hundreds of thousands of wells or more. Each of the wells has a unique address. The system includes a tray top comprised of a plurality of areas wherein each of the areas corresponds uniquely to each of the wells and includes a unique address. The system may include a second tray top also comprised of a plurality of areas with unique addresses which uniquely correspond to each of the wells. The areas on the tops have compounds bound to those areas which compounds bind to components present in the wells and are used to obtain specific material in each well for analysis.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: November 13, 2012
    Assignee: Single Cell Technology, Inc.
    Inventors: Chun-Nan Chen, James O. Bowlby, Jr., Richard Aleck Jorgensen
  • Patent number: 8298497
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: October 30, 2012
    Assignee: The Secretary of State for Defence
    Inventor: David James Squirrell
  • Patent number: 8298834
    Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: October 30, 2012
    Assignee: Meso Scale Technologies, L.L.C.
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Jeff D. Debad, Sudeep M. Kumar, George Sigal, Gisbert Spieles, Michael Tsionsky, Michael Warnock
  • Patent number: 8282896
    Abstract: Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to facilitate use of the carrier in conducting various types of analyses.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: October 9, 2012
    Assignee: Fluidigm Corporation
    Inventors: Geoffrey Richard Facer, Hany Ramaz Nassef
  • Patent number: 8277763
    Abstract: The present invention relates to a method of processing analyte using a portable incubator apparatus. The incubator apparatus 10 has a plurality of cavities 20 each configured to receive analyte to be incubated. The method comprises: receiving analyte in each of the plurality of cavities; incubating the analyte in the plurality of cavities, the incubator apparatus being operable to control temperatures of analyte contained in the plurality of cavities independently of each other; and moving the incubator apparatus from a first location to a second location while the analyte is being incubated, the incubator apparatus being configured to maintain desired incubation conditions independently of a supply of electrical power and apparatus external to the incubator apparatus as the incubator apparatus is being moved.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: October 2, 2012
    Assignee: Centeo Biosciences Limited
    Inventors: Philipp Steinmann, Gabriela Juárez Martinez
  • Patent number: 8273304
    Abstract: An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: September 25, 2012
    Assignee: Affymetrix, Inc.
    Inventors: Peter J. Coassin, Jack D. McNeal, David E. Helphrey
  • Patent number: 8257651
    Abstract: In one embodiment the present invention provides a blood analyte meter that is user-friendly and easy to use. In accordance with an embodiment of the present invention an analyte measurement device, for use with a test strip for determining the amount of an analyte in a sample, displays a hierarchy of information or options to a user. The hierarchy of information or options may include, among other information or options, subroutines that are performable by the processor of the device, stored data related to past tests performed by the user, and alarm features of the device. A user scrolls through and selects individual options or pieces of information by rotating and translating a rotatable user interface around and along an axis of rotation.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: September 4, 2012
    Assignee: AgaMatrix, Inc.
    Inventors: Joseph Flaherty, Timothy Golnik
  • Patent number: 8252607
    Abstract: The disclosure provides a simple and effective way of synthesizing robust organic-inorganic hybrid gels and ultra-thin films using vaporization of a gel precursor. The gels are synthesized at relatively low temperature allowing the activity of the immobilized species to be maintained. The disclosure provides robust, synthetic, selective, active and/or passive transport systems in the form of functional biologically active species and mechanisms for forming them. These systems allow selective and passive or active transport of ionic, molecular and biological species through the incorporation of functional biological molecules and biomolecular assemblies in a rigid matrix.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: August 28, 2012
    Inventors: Gautam Gupta, Gabriel Lopez, Plamen Atanassov
  • Patent number: 8236555
    Abstract: The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: August 7, 2012
    Assignee: Meso Scale Technologies, LLC
    Inventors: Selen A. Stromgren, Eli N. Glezer
  • Patent number: 8211365
    Abstract: An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: July 3, 2012
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Joseph M. Chiapperi, Mary Kay Golisano
  • Patent number: 8178058
    Abstract: In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the plate is placed into a carrier plate having open wells in register with the wells of the filter plate or one may use a wicking device or an underdrain attached to the bottom of the filter plate. Sufficient wash liquid is added to allow for filtration by the effect of gravity to occur. Cells are retained within the wells at a rate of 4 times that of other rapid methods.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: May 15, 2012
    Assignee: EMD Millipore Corporation
    Inventor: Jun Y. Park
  • Patent number: 8168134
    Abstract: A device for performing biological sample reactions comprising a plurality of flow cells each with at least one port for receiving reaction fluids delivered to a chamber of each flow cell and a manifold configured to receive the plurality of flow cells, wherein the manifold is configured to receive at least one reaction fluid, and wherein each flow cell is configured with a sample holder wherein the sample holder contains biological sample.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: May 1, 2012
    Assignee: Life Technologies Corporation
    Inventor: Dennis Lehto
  • Patent number: 8142734
    Abstract: A microplate in which a plurality of wells that are reaction vessels, in a substantially concave shape, to analyze components of a specimen are arranged in matrix, includes a first surface that passes through an opening plane of the wells; and a second surface that is directed to an opposite side to the first surface. The microplate also includes a well-identification information indicator that is arranged on the second surface included in a boundary portion between wells next to each other, and that indicates well identification information to identify each of the wells. The boundary portion between the wells next to each other has a thickness substantially equivalent to a depth of the wells.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: March 27, 2012
    Assignee: Beckman Coulter, Inc.
    Inventor: Tomohiko Takeuchi
  • Patent number: 8129198
    Abstract: A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: March 6, 2012
    Assignee: Corning Incorporated
    Inventors: Ye Fang, Ann M. Ferrie, Yulong Hong, Brian L. Webb
  • Publication number: 20120052595
    Abstract: A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built in stand is also taught.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 1, 2012
    Inventors: William Dean Wallace, Glen Ford
  • Patent number: 8080408
    Abstract: A bioassay substrate and method thereof is provide. In the bioassay substrate, a sample solution is dripped onto a spot area to which a plurality of detection substances is fixed and an interaction between the detection substance and a target substance in the sample solution is detected by fluorescent intensity. The substrate includes: a predetermined number of the spot areas placed in a well arranged on the surface of the substrate; and a fine uneven structure continuously formed on a bottom surface configuring the spot areas.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: December 20, 2011
    Assignee: Sony Corporation
    Inventor: Motohiro Furuki
  • Patent number: 8062900
    Abstract: A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: November 22, 2011
    Assignee: Corning Incorporated
    Inventor: Robert A. Modavis
  • Patent number: 8058073
    Abstract: An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: November 15, 2011
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Joseph M. Chiapperi, Mary Kay Golisano
  • Patent number: 8057754
    Abstract: Apparatuses and methods of aligning at least one tip of a tip manifold with a plurality of wells of a multiwell plate. The tip manifold includes a plate, at least one tip depending from the plate, a first tip alignment pin depending from the plate, and a second tip alignment pin depending from the plate. The second tip alignment pin opposes the first tip alignment pin. The multiwell plate includes a body defining a plurality of non-porous wells for holding biological material, a first alignment hole, and a second alignment hole. The second alignment hole opposes the first alignment hole.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: November 15, 2011
    Assignee: Cellectricon AB
    Inventors: Johan Pihl, Mattias Karlsson
  • Patent number: 8039270
    Abstract: Ellipsometry systems for imaging binding events between analytes in a sample and an array of ligands in an evanescent field generated by a beam of light reflected from the plane of the ligands is adapted to a multiwell plate structure in common use. In one example, a film of prism arrays is affixed to the underside of the plate with each prism array located in registry with a well and ligand arrays being immobilized on the (planar) bottom surface of the wells. The prism array may be formed in a film and juxtaposed with the bottom surface of the plate or a prism array can be made integral with the plate bottom of a multiwell plate.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: October 18, 2011
    Assignee: Maven Technologies, LLC
    Inventors: Shane C Dultz, David Ralin
  • Patent number: 7988932
    Abstract: The present invention provides a micro mechanical system for performing assays for determining the presence of one or more selected analytes in a sample. The device comprises of a base and a disposable strip with at least one reaction well and at least one moveable member capable of moving fluids and parts through the fluids in a defined reaction well. Reagents in the reaction chambers and or the moveable members, react with the sample to yield a physically detectable change. The moveable parts are capable of executing motions that either mix, move reaction components, exchange or systematically deliver reagents to targets in the cartridge. Sensors in the base are configured to detect and or quantify the presence of a sample in the reaction well and of analytes in the sample. The signal is converted to an output on a visual display window on the external part of the base.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: August 2, 2011
    Assignee: MEC Dynamics Corp
    Inventor: Emmanuel C. Mpock
  • Patent number: 7981664
    Abstract: Each well of a multiwell plate adapted to accept a plurality of biological samples for testing for the presence of analytes in the sample is further adapted herein for immobilizing on the side walls of a well a 3D arrangement of ligand arrays. A well is formed with planar side walls and a stack of sample separators is placed within a well in positions so as to not come in contact with ligand spots in the array(s). The spacing between each pair of adjacent separators in a stack forms a sample chamber in a position corresponding to an array of the 3D arrangement of ligand arrays.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: July 19, 2011
    Assignee: Maven Technologies, LLC
    Inventor: Shane C Dultz
  • Patent number: 7955573
    Abstract: A sample block for use in the polymerase chain reaction, DNA sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the block is improved by the inclusion of hollows in the block that are positioned to decrease the mass of the block in the immediate vicinity of the wells.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: June 7, 2011
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Sunand Banerji
  • Patent number: 7939030
    Abstract: The present invention provides a micro mechanical system for performing assays for determining the presence of one or more selected analytes in a sample. The device comprises of a base and a disposable strip with at least one reaction well and at least one moveable member capable of moving fluids and parts through the fluids in a defined reaction well. Reagents in the reaction chambers and or the moveable members, react with the sample to yield a physically detectable change. The moveable parts are capable of executing motions that either mix, move reaction components, exchange or systematically deliver reagents to targets in the cartridge. Sensors in the base are configured to detect and or quantify the presence of a sample in the reaction well and of analytes in the sample. The signal is converted to an output on a visual display window on the external part of the base.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: May 10, 2011
    Assignee: MEC Dynamics Corp.
    Inventor: Emmanuel C. Mpock