Abstract: A sample vial [24] is disclosed, having a generally tubular body [32]. The vial [24] has a generally round lip [34] defining an opening [36] at the top of the body [32]. The vial [24] has a foot [38] at the base of the body [32], having asymmetric first and second sides [40, 42]. A rack [28] is disclosed for supporting such a sample vial [24]. The rack [28] supports the sample vial [24] in a generally upright position in a single orientation. The rack [28] has an asymmetric recess [50] adapted to receive the asymmetric foot [38] in a single orientation. The rack [28] also has an orientation abutment [82] adapted to interfere with a projecting abutment [46] of a vial [24] to prevent insertion of a vial [24] into the asymmetric recess [50] in an orientation other than the single orientation. The orientation abutment [82] also allows insertion of a vial [24] into the asymmetric recess [50] in the single orientation.

Abstract: The invention provides a rack system containing an adapter for convenient application of small volumes of sample in a vessel to analysis.

Abstract: A vial retainer system for an automated processing apparatus. The vial retainer system includes a track mounted to the processing apparatus, a rack adapted to slide in a longitudinal direction on the track, and a vial retainer positioned over the rack. The rack is movable in a distal direction to install the rack on the processing apparatus, and in a proximal direction, opposite the distal direction, to remove the rack from the processing apparatus. The rack is adapted to hold one or more vials in an upright orientation. The vial retainer has one or more a sloped surfaces inclined such that a distal end of each sloped surface is closer to the track than a proximal end of each sloped surface.

Abstract: A cuvette holder for holding a plurality of reaction cuvettes is disclosed. The cuvette holder includes a body made by injection molding of a plastic material. The body extends along a circular segment and defines an array of chambers arranged along a circular segment, each of the chambers is for receiving, retaining and loosely holding the upper end portion of a reaction cuvette.

Abstract: A microchip processing apparatus processes a microchip with at least one main separation channel. The microchip processing apparatus includes a holding part configured to hold the microchip, a container containing a sample or a reagent, and a dispensing probe having a needle formed on a tip of the dispensing probe. The dispensing probe is actuated to be inserted into the container from above the container, to draw the sample or reagent, and to inject to a prescribed position on the held microchip. A dispensing probe driving mechanism moves the dispensing probe between prescribed positions of the microchip and the container.

Abstract: A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positioned between the sample carrier and the conveyor; advancing the sample carrier beyond the fixed registration elements; reversing the conveyor direction to back at least one of the sample carriers into contact with its corresponding registration elements; continuing to reverse the conveyor until all sample carriers are in contact with their respective registration elements; whereby the flexure elements of the sample carriers in contact with the respective registration elements will deform as the conveyor reverses to allow all sample carriers to contact their respective registration elements, thereby providing a known position of the sample carrier.

Abstract: A sample card for use in a spectroscopic analytical instrument. The card is preferably disposable and includes an aperture through the card in which there is positioned a sample supporting window on which a sample is adapted to be placed. The sample supporting window is made from a light energy transmitting material by one of the steps such as cleaving, fly cutting, chipping milling, sawing or scaling. A method of manufacturing the card and for using the card are also included where the method includes the step of providing light supporting window by forming that window by the aforedescribed processes.

Abstract: A histological specimen cassette for use in connection with a larger histological specimen cassette, wherein each histological specimen cassette has an internal chamber that includes a receptacle and a lid, the receptacle having a bottom wall, opposite side walls, opposite front and back walls, and an internal chamber or cavity, where the internal chamber or cavity is positioned between the sidewalls, the front and back walls and partially bound by the bottom wall, having a plurality of apertures that extend through the bottom wall and that create fluid passageways into the cavity, the lid having a plurality of apertures that extend through the lid and that create additional fluid passageways into the cavity, the histological specimen cassette being dimensioned such that the histological specimen cassette can fit entirely within the void of the larger histological specimen cassette when the lid is in the closed position.

Abstract: A reagent cup device 1 includes a plurality of individually sealed reagent cup compartments 7, each holding a reagent cup 8 having an open end and an inner surface, at least part of which is coated with a chemical reagent. Each reagent cup compartment 7 is closed and has a first end covered by a first breakable seal 5 and a second end covered by a second breakable seal 10. Since the reagent cup compartments 7 are individually sealed by the breakable seals 5, 10, it is possible to gain access to the interior of a reagent cup compartment 7, and thereby to the reagent cup 8 held therein, without breaking the sealing of the remaining reagent cup compartments 7. Thereby degradation of the chemical reagent in the reagent cups 8 is reduced, and the expected lifetime of the reagent cups 8 is accordingly increased. The breakable seals 5, 10 may be provided with weakened zones in order to easier break the seals 5, 10 when access is desired.

Abstract: Kits and methods for qualifying automated biological screening system. At least one biological specimen having a plurality of marked target zones (MTZs) exhibiting an attribute is provided. The biological specimen(s) is processed through the automated biological screening system to determine locations of biological objects suspected of exhibiting the attribute. The locations of the MTZs can be compared to the locations of the suspicious biological objects in order to determine a number of matches. The automated biological screening system can then be qualified based on the number of matches, and optionally based on statistical information related to the biological specimen. The statistical information can be acquired by processing the biological specimen through a qualified automated biological screening system over a number of runs.

Abstract: A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue embedding material. The tissue cassette further includes a port disposed in the housing, the port in fluid communication with the compressible reservoir at one end and terminating in a sample cavity at another end. During operation, the compressible reservoir is compressed or squeezed to release the tissue embedding material into the sample cavity containing the biological sample.

Abstract: The present invention contemplates a handling device for a biological specimen. The handling device includes a substrate with at least one crease that divides the substrate into a handle portion and a receiving portion that includes an aperture having a perimeter that is configured so that it receives a container having a cover that includes a biological specimen for testing, while resisting pull-through of the container relative to the substrate.

Abstract: A pharmaceutical sample storage system in which the accommodation volume of a case is increased is disclosed and claimed. The molding of the storage rack is easy. The cases in the storage rack are locked in place and will not fall out even if the storage rack is turned upside down. Placing and removing cases from the storage rack is highly accurate. The sample storage system is sealed and the storage rack vertically accommodates a plurality of cases in a matrix. The cases are rectangular in cross-section and are hollow. The cases are tapered toward the bottom portion of the case and the outer surfaces of the cases are chamfered. The storage rack has a lower grate-shaped bottom portion which is partitioned by cross members. The bottom portion of the case being fitted into one partitioned portion of the grate-shaped bottom portion and has case supporting pins vertically provided upward from each intersection of gratings or cross members of the grated bottom portion.