Abstract: Provided herein is a pharmaceutical or oral care product for treating or preventing oral diseases that is prepared with proteoglycan 4 (PRG4) as an active ingredient, the preparing method thereof and the use thereof in manufacturing medicaments or oral care products for treating or preventing oral diseases and maintenance of oral health. PRG4 may have efficacy in maintaining oral health and treating or preventing oral disease. This secreted glycoprotein, which is also called lubricin and superficial zone protein, is known to protect against frictional forces, cell adhesion and protein deposition.

Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.

Abstract: The present invention is directed to the use of antibiotics for preparing topical oral antibiotic formulations for treating and/or preventing black-line stains. This invention is further directed to a method of treating and/or preventing black-line stains comprising administration of a topical oral antibiotic formulation. The invention is additionally directed to a topical oral antibiotic formulation for use in treating and/or preventing black-line stains.

Abstract: This document provides methods and materials for providing teeth with a white appearance. For example, methods and materials for contacting teeth with one or more fluorescence emitting polypeptides (e.g., a blue fluorescent protein (BFP)) to provide the teeth with a whiter appearance are provided.

Abstract: The present invention relates to a liquid, cleaning and/or cleansing composition comprising abrasive cleaning particles.

Abstract: A formulation for an oral care application comprises a linear polyphosphate or a polyphosphate blend having a short average effective chain length. The polyphosphate blend may further comprise a cyclic phosphate and a linear polyphosphate. The formulation provides whitening effects, decreased tooth sensitivity, strengthened tooth enamel, and remineralization. The present invention further relates to methods for making an oral care formulation comprising a linear polyphosphate or a polyphosphate blend having a short average effective chain length. Methods of applying an oral care formulation comprising a linear polyphosphate or a polyphosphate blend having a short average effective chain length are also disclosed.

Abstract: A thickening additive composition comprising: (A) a substantially anhydrous solvent system; and (B) a thickening agent, wherein the thickening agent comprises a strongly swellable, lightly to moderately crosslinked polyvinylpyrrolidone. Personal care compositions containing the thickening additive composition are also described.

Abstract: Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

Abstract: It comprises the use of D-fagomine or derivatives thereof in the prevention and/or coadjuvant treatment of bacterial infections, as well as to pharmaceutical, veterinary, or food and feed, pet food compositions containing them.

Abstract: The present invention relates to taste improvement of foodstuffs, beverages, tobacco products and oral care products, using a substance according to formula (I), edible salts or edible esters thereof: It was found that substances represented by formula (I) are capable of modifying and complementing, the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavour compositions, foodstuffs, tobacco products and oral care products.

Abstract: Provided herein is a strip, shaped for the application to the labile surface of the front teeth and/or gums of a subject, which strip is provided with at least one oral care composition for delivery to a pre-determined area of the teeth and/or gums of the subject. Also provided herein are uses for delivery of compositions. Further provided are uses of the strip in combination with a dental device.

Abstract: Described herein, are dental strips comprising a film backing, and an adhesive layer, the adhesive layer comprising a water-swellable polymer and at least one active agent; and uses thereof.

Abstract: Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

Abstract: Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

Abstract: Flavored chewable foams for the oral care sector are produced from a polyurethane-polyurea and a sensorially active substance (e.g., taste substance and/or aroma substance) by foaming a polyurethane-urea dispersion, drying that dispersion and incorporating the sensorially active substance into the polyurethane-urea dispersion before, during or after foaming of the dispersion.

Abstract: Disclosed are topical oral compositions comprising a safe and effective amount of an antimicrobial agent in admixture with a pharmaceutically acceptable carrier, the compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and in inhibiting the spread into the bloodstream of pathogenic oral bacteria, associated bacterial toxins and endotoxins, and resultant inflammatory cytokines and mediators. Also disclosed are methods of use of these topical antimicrobial oral compositions to reduce the risk of developing an oral bacteria-induced systemic disease and to promote whole body health in humans and other animals.

Abstract: The invention provides oral compositions including a safe and effective amount of a compound represented by the formula (I): wherein R1 and R2 are independently selected from a hydrogen atom and an alkyl group and X? is an anion, and n is an integer of 1 to 25; and (b) a surfactant.

Abstract: Carbohydrate-derived fulvic acid (CHD-FA), a salt, ester or derivative thereof for use in the prevention, treatment or inhibition of infection by oral pathogens in a mammal, compositions, particularly compositions suitable for oral administration, comprising the same.

Abstract: Described herein are compositions comprising a combination of extracts, and methods of preparing and using the same.

Abstract: Described herein are compositions comprising a combination of extracts, and methods of preparing and using the same.

Abstract: Described herein are compositions comprising a combination of extracts comprising a mixture of extracts from at least three of Punica granatum, Myristica fragrans, Zingiber officinale, and Zizyphus joazeiro and a natural extract other than the extract from at least three of Punica granatum, Myristica fragrans, Zingiber officinale, and Zizyphus joazeiro; and an orally acceptable carrier, and methods of preparing and using the same.

Abstract: Described herein are compositions comprising a combination of extracts, and methods of preparing and using the same.

Abstract: Hydrogel particles include: (A) a water-insoluble complex containing catechins; (B) a compound which forms chelate together with divalent or trivalent metal ions; (C) a divalent or trivalent metal salt; (D) a gel-forming agent; and (E) water.

Abstract: Organic compounds of formula (I) wherein: X is N, or C, R1-R6 may be independently selected from the group consisting of, H, substituted, unsubstituted, branched or unbranched C1-C4 alkyl, methoxy, ethoxy, Br, F, Cl, provided that when X is nitrogen there is no substituent at R6 Y is an alkylene group of the formula (CR7R8)m wherein R7 and R8 may be independently selected from the group consisting of hydrogen, substituted, unsubstituted, branched or unbranched C1-C4 alkylene, and m is an integer selected from 1 to 6. The compounds create or modify flavour, in particular sweet flavour and may be used in compositions and consumable products.

Abstract: A topical anesthetic for dental procedures is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the oral mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle may additionally include a penetration enhancer such as propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.

Abstract: Disclosed are oral care compositions and the use of such oral care compositions for treating or preventing oral malodor. Also disclosed are methods for treatment or prevention of oral malodor. The oral care compositions include serine in an amount effective to reduce oral malodor caused by hydrogen sulfide and/or indole.

Abstract: A natural toothpaste having a unique jelly-like composition and sweet flavor capable of providing sufficient oral hygiene care.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract: The present invention relates to a pharmaceutical composition comprising a peptide of 5 to 50 amino acids which comprises the amino acid sequence NPFPTX1X2KRX3X4 (SEQ ID NO: 2) wherein X1, X2, X3, and X4 may be the same or different and each is an amino acid residue, wherein said composition is in a form suitable for a transbuccal administration and use thereof for preventing or treating pain.

Abstract: This invention relates to a bipolar antimicrobial particle for use in laundry detergent compositions, fabric conditioners, personal care and cosmetic compositions and a process for making the same. In view of the foregoing, it is an object of the present invention to provide a stabile antimicrobial agent immobilised on a carrier particle. It is a further objective to provide an antimicrobial particle with improved retention to the fabric so that larger amounts of antimicrobial will be available even after rinsing. Surprisingly it has been found that antimicrobial molecules tagged by surface reaction onto naturally occurring asymmetric clay surfaces, act as an antimicrobial particle with improved retention properties with improved stability.

Abstract: Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

Abstract: A tooth bleaching catalytic, the manufacturing method and the applications thereof are provided, wherein the tooth bleaching catalytic comprises a plurality of mesoporous silica nano-particles (MSNs), and the MSNs at least comprise a condensate having histidine, silane and a plurality of metal ions.

Abstract: The present invention generally relates to oral compositions such as toothpastes, toothpowders, liquid dentrifices, mouthwashes, rinses, dental floss, denture cleansers, chewing gums, lozenges and the like. In particular, it relates to such oral compositions that include cesium and rubidium salts. In one aspect of the present invention, a composition for oral use is provided. The composition includes a cesium or rubidium salt and water having a surface tension ranging between 45 and 70 dynes per cm2. In another aspect of the present invention, a method for improving oral hygiene in a mammal is provided. The method involves taking a volume of a solution into the mammal's mouth, where the solution includes a cesium or rubidium salt and water having a surface tension ranging between 45 and 70 dynes per cm2, swishing the solution around and expelling the solution.

Abstract: A stable flowable aqueous composition comprising at least two component surfactants, each component surfactant having a maximum solubility in water at which a saturated solution forms, wherein the total concentration of all surfactants present in the composition is greater than would be obtained by combining equivalent amounts of saturated solutions of the component surfactants; wherein at least one component surfactant includes a compound of formula (I): wherein R1 represents a C4-36 alkyl group; each of R2, R3, R4 and R5 independently represents a hydrogen atom or a C1-4 alkyl group and wherein at least one of R2, R3, R4 and R5 is not hydrogen and M? represents a cation.

Abstract: A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.

Abstract: Oral care compositions comprising a capsules comprising flavoring and/or one or more active ingredients, and/or flavours, said capsules distributed in an orally acceptable vehicle or carrier.

Abstract: The present invention is directed to oral compositions comprising an orally-acceptable carrier and a silica abrasive comprising a precipitated amorphous silica compound having an average particle size of from 5 ?m to 20 ?m, oil absorption of from 60 cc/100 g to 120 cc/100 g, and an Einlehner hardness of from 4 to 11, and methods of use thereof

Abstract: The present invention is directed to improved sweetener compositions and oral care compositions, especially those in the form of a toothpaste or oral/dental rinse, comprising the same. The sweetener composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of similar sucrose equivalence and type, preferably in a ratio of about 1:about 1:about 2. The sweetener composition of the invention was found to significantly improve the taste profile, long lasting freshness and clean feel of oral care compositions and to deliver an in-use sweetness that was more natural and pleasant than artificial sweeteners alone.

Abstract: Described are associative thickeners based on compounds which comprise at least one hydrophobically modified polyether dendron end group.

Abstract: The present invention relates to personal care compositions comprising certain dye-polymer complexes. Additionally, methods for coloration of personal care compositions using said dye-polymer complexes are disclosed.

Abstract: An abrasive dentifrice composition which effects enhanced antiplaque and breath freshening properties which comprises an orally acceptable vehicle containing a combination of a safe and effective amount of an antibacterial agent and at least two enzyme ingredients.

Abstract: A stabilized topical composition comprising a borinic acid derivative, e.g., a borinic ester.

Abstract: The invention describes the modification of polyamine-based materials to form polyguanidine compounds that are useful for their antimicrobial, anticaries, and muccoadhesive properties. The present invention also relates to methods for preventing or treating periodontal disease and caries which include delivering a therapeutically effective amount of an oral composition containing a polyguanidine compound into an oral cavity.

Abstract: A liquid composition that is applied to teeth in advance of a whitening gel or paste. The liquid composition is preferably in a viscous gel form, such that when the composition is applied to teeth, it does not flow quickly off the teeth. The composition contains ne diluent; oxidizer; buffering agent; suspending agent; emollient; surface active agent; germicide; gelling agent; optionally one or more flavoring components selected from flavor stabilizers, sweeteners, and taste enhancers; and pH control agent.

Abstract: An exfoliating dentifrice composition is described that contains a plurality of granules and an orally acceptable vehicle. The granules include at least one polymeric binding agent. The composition includes at least one abrasive agent having an average particle diameter of 0.01 mm to 4 mm. Also included are methods of exfoliating an oral cavity soft tissue by use of the composition.

Abstract: The invention encompasses compositions and methods for treating and modifying surfaces of teeth, which compositions include calcium and magnesium containing silicates or silica, cationic polymer modified silica or combinations thereof. The composition when applied to the teeth or a tooth surface deposit on such surfaces to repair acid damaged enamel and prevent further erosion of a tooth surface.

Abstract: The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

Abstract: The invention encompasses oral care compositions comprising one or more active component and one or more adhesive polymers, which cause the active component to adhere to the tooth surface. In certain embodiments the active agent is an occlusion agent. The invention also encompasses methods of treating the teeth or a teeth surface with an active agent. In certain embodiments, the invention encompasses treating the teeth with an occlusion agent to prevent or alleviate tooth sensitivity.

Abstract: Isolated nucleic acid sequences and amino acid sequences for soluble, ?-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies which tightly adhere to surface but which are unable to release cells into the medium or spread over the surface is also provided. In additions, methods are described for modulating detachment of bacterial cells from biofilm by mutating soluble, ?-N-acetylglucosaminidase or altering its expression or activity are also provided. Also provided are compositions, methods and devices for preventing, inhibiting and treating bacterial infections.