Gastrointestinal System (e.g., Intestine, Stomach, Gall Bladder, Etc.) Patents (Class 424/551)
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Publication number: 20140335144Abstract: The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.Type: ApplicationFiled: May 23, 2014Publication date: November 13, 2014Applicant: MESYNTHES LTD.Inventors: Brian Roderick WARD, Keryn Dallas JOHNSON, Barnaby Charles Hough MAY
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Publication number: 20140328939Abstract: The present invention relates to a method for preparing a biocompatible small intestinal submucosa hydrogel with a controllable in-vivo degradation period, more particularly to a method for preparing a small intestinal submucosa hydrogel which is formed in a solution phase by forming chemical crosslinkages by solubilizing a biocompatible small intestinal submucosa powder and allows the degradation period of a gel formed during in-vivo injection by controlling the degree of crosslinking and a method for preparing a small intestine submucosa drug carrier or a small intestine submucosa support using the hydrogel.Type: ApplicationFiled: April 2, 2012Publication date: November 6, 2014Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Da Yeon Kim, Moon Suk Kim, So Mi Yoon, Bit Na Lee
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Patent number: 8877224Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.Type: GrantFiled: May 24, 2012Date of Patent: November 4, 2014Assignee: CorMatrix Cardiovascular, IncInventors: Robert G. Matheny, Beecher C. Lewis
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Patent number: 8871511Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.Type: GrantFiled: June 11, 2013Date of Patent: October 28, 2014Assignee: CorMatrix Cardiovascular, IncInventors: Robert G Matheny, Anna Fallon
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Patent number: 8846625Abstract: Analogs of glucagon-like peptide 2, a product of glucagon gene expression, have been identified as intestinal tissue growth factors. Their formulation as pharmaceutical, and therapeutic use in treating disorders of the small bowel, are described.Type: GrantFiled: March 11, 2013Date of Patent: September 30, 2014Assignee: 1149336 Ontario Inc.Inventors: Daniel J Drucker, Anna E. Crivici, Martin Sumner-Smith
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Publication number: 20140271472Abstract: Lung volume reduction by isolating a target lung portion from the rest of the lung with a mass of extracellular matrix (“ECM”) material. The procedure can be performed by locating a tube within the lumen of an airway to be obstructed and depositing an amount of flowable or other ECM in the open space until the lumen is occluded. Optionally, the procedure may be performed by delivering a plug substantially comprised of ECM material into the lumen of an airway to be obstructed. Further optionally, the ECM plug may include a one-way valve to allow air and mucous to escape from the isolated lung portion.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventors: UMESH H. PATEL, BHAVIN SHAH, MICHELLE CHUTKA
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Publication number: 20140271784Abstract: Methods for defatting omentum and processes for preparing an acellular omentum, i.e., devitalized or decellularized omentum, comprising extracellular matrix for implantation into a mammalian system. Constructs for medical applications comprising decellularized omentum are also described. More specifically, mesh reinforced omentum biomatrix for soft tissue repair is described.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: Ehitcon, Inc.Inventors: Chunlin Yang, Qiang Zhang, Ilya Koyfman, Ziwei Wang, Daphne Anne Salick Ryan, Robert B. Vetrecin, Philip M. Steele
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Publication number: 20140242184Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: ApplicationFiled: May 5, 2014Publication date: August 28, 2014Inventor: Robert G Matheny
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Publication number: 20140242183Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: ApplicationFiled: May 5, 2014Publication date: August 28, 2014Inventor: Robert G. Matheny
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Patent number: 8808392Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: GrantFiled: October 31, 2007Date of Patent: August 19, 2014Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
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Publication number: 20140227364Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.Type: ApplicationFiled: February 7, 2014Publication date: August 14, 2014Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
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Patent number: 8802158Abstract: According to the present invention there are provided methods of use in companion animals of probiotic bacteria of the genus Lactobacilli.Type: GrantFiled: June 25, 2010Date of Patent: August 12, 2014Assignees: The Iams Company, Alimentary Health, Ltd.Inventors: Thomas William-Maxwell Boileau, Michael Anthony Ceddia, Gary Mitchell Davenport, Barry Pius Kiely, Liam Diarmuid O'Mahony, Gregory Dean Sunvold, Mark Alan Tetrick, Robert Jason Vickers
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Patent number: 8802436Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.Type: GrantFiled: February 7, 2014Date of Patent: August 12, 2014Assignee: ACell, Inc.Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
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Publication number: 20140220095Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.Type: ApplicationFiled: January 24, 2014Publication date: August 7, 2014Applicant: LifeCell CorporationInventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
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Patent number: 8795728Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: August 5, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8785197Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: September 27, 2013Date of Patent: July 22, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8785198Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: September 27, 2013Date of Patent: July 22, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8784891Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: July 22, 2014Assignee: CorMatrixCardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8771737Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: July 8, 2014Assignee: CorMatrix Cardiovascular, IncInventor: Robert G Matheny
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Patent number: 8758781Abstract: The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.Type: GrantFiled: February 19, 2013Date of Patent: June 24, 2014Assignee: Mesynthes Ltd.Inventors: Brian Roderick Ward, Keryn Dallas Johnson, Barnaby Charles Hough May
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Patent number: 8753885Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: June 17, 2014Assignee: CorMatrix Cardiovascular, IncInventor: Robert G Matheny
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Patent number: 8753886Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: May 1, 2013Date of Patent: June 17, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Publication number: 20140161900Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: ApplicationFiled: September 27, 2013Publication date: June 12, 2014Inventor: Robert G. Matheny
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Patent number: 8734841Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: May 27, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8734842Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: May 27, 2014Assignee: CorMatrix Cardiovascular, IncInventor: Robert G Matheny
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Patent number: 8735155Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: September 27, 2013Date of Patent: May 27, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Patent number: 8691276Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.Type: GrantFiled: November 26, 2012Date of Patent: April 8, 2014Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen F. Badylak, Donald Freytes
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Publication number: 20140086867Abstract: A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target location on the scalp of the subject to induce an inciting event at the target scalp location, and (iii) administering a therapeutically effective amount of said ECM composition to the target scalp location. In some embodiments, the ECM composition includes at least one additional biologically active agent.Type: ApplicationFiled: September 19, 2013Publication date: March 27, 2014Inventor: Robert G. Matheny
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Publication number: 20140088339Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.Type: ApplicationFiled: March 1, 2013Publication date: March 27, 2014Applicant: Francis Law GroupInventor: Robert Matheny
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Patent number: 8673861Abstract: Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.Type: GrantFiled: April 16, 2012Date of Patent: March 18, 2014Assignee: Araim Pharmaceuticals, Inc.Inventors: Anthony Cerami, Michael Brines, Thomas Coleman
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Patent number: 8642084Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: GrantFiled: January 2, 2013Date of Patent: February 4, 2014Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G Matheny
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Publication number: 20130287741Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.Type: ApplicationFiled: December 12, 2012Publication date: October 31, 2013Inventor: AlloSource
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Patent number: 8568761Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. Methods for regenerating defective or absent myocardium apply a composition to a site of myocardium in need of regeneration using a delivery mode appropriate for the particular formulation.Type: GrantFiled: July 15, 2005Date of Patent: October 29, 2013Assignee: CorMatrix Cardiovascular, Inc.Inventor: Robert G. Matheny
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Patent number: 8535719Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.Type: GrantFiled: July 6, 2007Date of Patent: September 17, 2013Assignee: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
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Publication number: 20130236453Abstract: Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described.Type: ApplicationFiled: March 12, 2013Publication date: September 12, 2013Applicant: THE OHIO STATE UNIVERSITYInventors: Carlo M. Croce, Ramiro Garzon
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Publication number: 20130224260Abstract: The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.Type: ApplicationFiled: February 19, 2013Publication date: August 29, 2013Applicant: Mesynthes Ltd.Inventor: Mesynthes Ltd.
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Patent number: 8455008Abstract: Described are medical graft materials and devices having improved properties relating to their component profiles.Type: GrantFiled: June 5, 2012Date of Patent: June 4, 2013Assignee: Cook Biotech IncorporatedInventor: Chad E. Johnson
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Publication number: 20130129833Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: ApplicationFiled: January 2, 2013Publication date: May 23, 2013Inventor: Robert G. Matheny
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Publication number: 20130122108Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.Type: ApplicationFiled: January 2, 2013Publication date: May 16, 2013Inventor: Robert G Matheny
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Patent number: 8439942Abstract: A medical device (40) including a collagenous biomaterial (10) for causing embolus and treating an aneurysm. The collagenous biomaterial (10) includes a small intestine submucosa (12) that is configured into various components (16) for causing a vascular occlusion or a packing aneurysm lumen.Type: GrantFiled: December 3, 2010Date of Patent: May 14, 2013Assignee: Cook Bioteck IncorporatedInventors: Christopher J. Moran, Thomas G. Kozma, Umesh H. Patel, Mark W. Bleyer
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Patent number: 8415159Abstract: The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.Type: GrantFiled: July 30, 2009Date of Patent: April 9, 2013Assignee: Mesynthes Ltd.Inventors: Brian Roderick Ward, Keryn Dallas Johnson, Barnaby Charles Hough May
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Patent number: 8361503Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.Type: GrantFiled: February 29, 2008Date of Patent: January 29, 2013Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Stephen F. Badylak, Donald O. Freytes
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Publication number: 20120251507Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.Type: ApplicationFiled: May 24, 2012Publication date: October 4, 2012Applicant: CORMATRIX CARDIOVASCULAR, INC.Inventors: ROBERT G. MATHENY, Beecher C. Lewis
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Publication number: 20120226218Abstract: Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically.Type: ApplicationFiled: September 2, 2010Publication date: September 6, 2012Inventors: Mary Phillips, Elad Maor, Boris Rubinsky, Jacob Lavee
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Patent number: 8236354Abstract: A method for treating a cancer, by determining a patient to have an ECOG (Eastern Cooperative Oncology Group) score of 0 or 1 and selecting that patient for treatment, and administering to the patient an effective amount of an immunomodulating composition comprising small molecular weight components of less than 3000 daltons, and having the following properties: (i) is extracted from bile of animals; (ii) is capable of stimulating monocytes and/or macrophages; (iii) is capable of modulating tumor necrosis factor production and/or release; (iv) contains no measurable level of IL-1?, IL-1?, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-?; (v) is not cytotoxic to human peripheral blood mononuclear cells; and (vi) is not an endotoxin.Type: GrantFiled: February 17, 2012Date of Patent: August 7, 2012Assignee: ZOR Pharmaceuticals, LLCInventors: Daniel Tyree Gregory, Jr., Stephan Dale Glenn, Asher Nathan
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Patent number: 8192763Abstract: Described are medical graft materials and devices having improved properties relating to their component profiles.Type: GrantFiled: July 23, 2008Date of Patent: June 5, 2012Assignee: Cook Biotech IncorporatedInventor: Chad E. Johnson
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Publication number: 20120135045Abstract: Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs are biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.Type: ApplicationFiled: June 21, 2011Publication date: May 31, 2012Applicant: Organogenesis, Inc.Inventors: Andrew J. Nixon, Ginger A. Abraham-Freel, Patrick R. Bilbo
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Patent number: 8187619Abstract: Described are medical graft materials and devices having improved properties relating to their component profiles.Type: GrantFiled: April 16, 2010Date of Patent: May 29, 2012Assignee: Cook Biotech IncorporatedInventor: Chad E. Johnson
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Publication number: 20120076869Abstract: Dementia is treated by administering a composition that includes an omentum tissue or an aqueous or organic extract of the omentum tissue to a mammal in need of treatment of dementia. The composition can be administered to the mammal via oral administration, parenteral administration, inhalation, topical administration, rectal administration, vaginal administration, implantation, or any combinations thereof. The mammal can also be treated by stimulating a tissue that includes omentum.Type: ApplicationFiled: December 1, 2011Publication date: March 29, 2012Inventor: SURINDER SINGH SAINI
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Publication number: 20120034191Abstract: The invention is compositions of extracellular matrix that comprise mammalian extracellular matrix from two or more tissue sources in a mammal. The invention also includes methods of using these compositions to regenerate tissue or generate new tissue at sites of defects or wounds in mammals.Type: ApplicationFiled: February 23, 2011Publication date: February 9, 2012Inventor: Robert G. Matheny