Gastrointestinal System (e.g., Intestine, Stomach, Gall Bladder, Etc.) Patents (Class 424/551)
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Publication number: 20030059406Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030059409Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030059404Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030059407Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030059405Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030059411Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.Type: ApplicationFiled: October 25, 2002Publication date: March 27, 2003Applicant: ACell, Inc.Inventor: Alan R. Spievack
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Publication number: 20030012823Abstract: A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.Type: ApplicationFiled: September 3, 2002Publication date: January 16, 2003Inventors: Sherry L. Voytik-Harbin, Andrew O. Brightman, Ryan M. Meixner, Beverly Z. Waisner
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Publication number: 20030003159Abstract: A Chinese medicinal composition useful in preventing and treating cancer comprises:Type: ApplicationFiled: May 20, 2002Publication date: January 2, 2003Inventor: Yongzhong Li
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Patent number: 6485723Abstract: An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.Type: GrantFiled: May 8, 2000Date of Patent: November 26, 2002Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Christina Lindberg, George B. Boder, Sherry Voytik-Harbin
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Patent number: 6482443Abstract: Disclosed are an antler herb medicine and a preparing method thereof. The antler herb medicine is prepared by fermenting a mixture of antler and gizzard membrane at 20-60° C. In the mixture, the weight ratio of antler to gizzard membrane is within the range of 1:10 to 10:1. The antler herb medicine contains all of the efficacious components of antler, rather than selected components. Also, the fermentation of antler brings about a great change in the composition of antler, converting high molecular weight proteins into low molecular weight proteins and polypeptides, so that the antler herb medicine is greatly improved in uptake rate in the body. Thus, the antler herb medicine can show medicinal effects of antler at a small amount.Type: GrantFiled: June 18, 2001Date of Patent: November 19, 2002Inventor: Youn-Soo Lee
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Patent number: 6455078Abstract: The present invention provides a herbal pharmaceutical composition for treating patients with liver diseases and/or HIV. The composition contains fifteen (15) ingredients, which are diffuse hedyotis, bistort rhizome, giant knotweed rhizome, Asiatic moonseed rhizome, baical skullcap root, bovine biliary powder, milkvetch root, barbary wolfberry fruit, sanqi, red ginseng, figwort root, Chinese magnoliavine fruit, turmeric root-tuber, hawthorn fruit, and Chinese angelica. Among the fifteen (15) ingredients, diffuse hedyotis, bistort rhizome, giant knotweed rhizome, and Chinese magnoliavine fruit are the required herbs which contribute to the efficacy of the pharmaceutical composition.Type: GrantFiled: July 18, 2001Date of Patent: September 24, 2002Inventor: Tzu-Sheng Wu
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Patent number: 6444229Abstract: A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.Type: GrantFiled: July 23, 2001Date of Patent: September 3, 2002Assignee: Purdue Research FoundationInventors: Sherry L. Voytik-Harbin, Andrew O. Brightman, Ryan M. Meixner, Beverly Z. Waisner
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Publication number: 20020115176Abstract: This invention provides novel PDE11 genes and polypeptides, and variants, homologues, fragments, and derivatives thereof. This invention also provides vectors and host cells comprising the disclosed nucleotide sequences. This invention further provides antibodies that bind to the PDE11 polypeptides. This invention further yet provides methods for identifying agents that affect the expression or activity of the PDE11 genes and polypeptides. This invention also provides pharmaceutical compositions comprising the PDE11 genes or polypeptides, or inhibitors thereof. This invention additionally provides methods for treating diseases and conditions related to PDE11 activity, or the inhibition thereof.Type: ApplicationFiled: May 27, 1999Publication date: August 22, 2002Inventors: JEREMY LANFEAR, NICOLA M. ROBAS
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Patent number: 6419911Abstract: The invention is a psyllium containing snack bar. Also included as part of the invention are processes for making snack bars. The product may be used in a therapeutic or dietary regime, for purposes such as increasing dietary fiber or for reducing cholesterol. Dry mixes for making psyllium containing snack bars are also a feature of the invention.Type: GrantFiled: September 17, 1993Date of Patent: July 16, 2002Assignee: Board of Trustees of Michigan State UniversityInventor: John Bailey
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Publication number: 20020076446Abstract: The present invention provides a herbal pharmaceutical composition for treating patients with liver diseases and/or HIV. The composition contains fifteen (15) ingredients, which are diffuse hedyotis, bistort rhizome, giant knotweed rhizome, Asiatic moonseed rhizome, baical skullcap root, bovine biliary powder, milkvetch root, barbary wolfberry fruit, sanqi, red ginseng, figwort root, Chinese magnoliavine fruit, turmeric root-tuber, hawthorn fruit, and Chinese angelica. Among the fifteen (15) ingredients, diffuse hedyotis, bistort rhizome, giant knotweed rhizome, and Chinese magnoliavine fruit are the required herbs which contribute to the efficacy of the pharmaceutical composition.Type: ApplicationFiled: July 18, 2001Publication date: June 20, 2002Inventor: Tzu-Sheng Wu
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Patent number: 6399105Abstract: Methods and compositions of matter are described for treatment of inflammatory autoimmune and other diseases by administration of lipid fractions of sea cucumber tissue. Compositions of matter useful for inclusion in aquatic and human diets are also disclosed.Type: GrantFiled: August 15, 2000Date of Patent: June 4, 2002Inventor: Peter Donald Collin
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Patent number: 6387878Abstract: The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.Type: GrantFiled: March 6, 2000Date of Patent: May 14, 2002Assignee: Children's Hospital Inc.Inventors: Gail E. Besner, Srikumar B. Pillai
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Patent number: 6375989Abstract: A method for preparing a bioactive extract from warm-blooded vertebrate submucosal tissue is described. The submucosal tissue is extracted using an aqueous solution of extraction excipients, and the extracted bioactive components are then separated from the extraction excipients to provide an isolated extract enriched in bioactive components. The isolated extract is useful, inter alia, as additive for cell growth media to promote cell growth and proliferation in vitro.Type: GrantFiled: June 10, 1999Date of Patent: April 23, 2002Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Andrew O. Brightman, Jason P. Hodde, Timothy B. McPherson, Sherry L. Voytik-Harbin
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Patent number: 6358284Abstract: An easy-to-produce and mechanically strong tube of an implantable graft prosthesis has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the graft prosthesis generally involves wrapping multiple sheets of a purified, collagen-based matrix structure around a mandrel, compressing and drying the tissue on the mandrel before removing the construct for eventual use.Type: GrantFiled: June 2, 1999Date of Patent: March 19, 2002Assignees: Med Institute, Inc., Cook Biotech, Inc.Inventors: Neal E. Fearnot, Michael C. Hiles
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Publication number: 20020001626Abstract: A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.Type: ApplicationFiled: July 23, 2001Publication date: January 3, 2002Inventors: Sherry L. Voytik-Harbin, Andrew O. Brightman, Ryan M. Meixner, Beverly Z. Waisner
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Patent number: 6331319Abstract: A tissue graft composition comprising submucosal tissue that has been enzymatically treated with galactosidase is described. The galactosidase modified submucosal tissue can be implanted to replace or support damaged or diseased tissues or utilized to form a cell culture growth substrate.Type: GrantFiled: February 2, 2000Date of Patent: December 18, 2001Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Rae Denese Record, Timothy B. McPherson
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Patent number: 6296879Abstract: A method to improve the health and growth of suckling dairy calves on dairy farms includes supplementing calves' diets with a ruminal fluid preparation obtained from the rumen of a cow. This supplement provides the calves with the protection needed to develop faster and healthier. It also leads to a decreased incidence of scours in the treated calves.Type: GrantFiled: September 8, 1999Date of Patent: October 2, 2001Assignees: Cornell Research Foundation, Inc., The United States of America as represented by the United States Department of AgricultureInventors: Thomas V. Muscato, James B. Russell
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Patent number: 6294350Abstract: In accordance with the present invention, fibroproliferative disease or condition characterized by such symptoms as increased levels of c-Jun homodimers, increased heterodimerization of c-Jun with another signaling peptide, increased levels of phosphorylated c-Jun, or increased presence of Jun kinase are treated by administering to the subject an amount of a compound effective to ameliorate one or more of the symptoms of the disease or condition, for example, an antiproliferative or antifibrotic agent. Preferred compounds for administration according to the invention are antisense c-Jun oligonucleotides and compounds that block c-Jun phosphorylation, such as pentoxifylline, or a functional derivative or metabolite thereof. Also provided by the present invention are in vitro tests for identifying whether a test compound is useful for treatment of a subject afflicted with such a disease and kits useful for conducting such assays.Type: GrantFiled: November 2, 1999Date of Patent: September 25, 2001Assignee: Dalhousie UniversityInventor: Theresa C. Peterson
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Patent number: 6264992Abstract: A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.Type: GrantFiled: August 15, 2000Date of Patent: July 24, 2001Assignee: Purdue Research FoundationInventors: Sherry L. Voytik-Harbin, Andrew O. Brightman, Ryan M. Meixner, Beverly Z. Waisner
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Patent number: 6255502Abstract: A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal penetration of the basic drug. The acid addition salts, an inclusion complex containing said salts and a use of said salts are also disclosed.Type: GrantFiled: April 19, 1999Date of Patent: July 3, 2001Assignee: Farmarc Nederland B.V.Inventors: Lawrence John Penkler, Luéta-Ann De Kock, Darryl Vanstone Whittaker
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Patent number: 6239105Abstract: The present invention comprises homeopathic preparations of purified growth hormone, as well as methods and systems for delivery of such preparations and treatment of disorders and conditions by administering such preparations.Type: GrantFiled: February 17, 1999Date of Patent: May 29, 2001Inventor: Barbara A. Brewitt
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Patent number: 6191109Abstract: The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.Type: GrantFiled: October 29, 1998Date of Patent: February 20, 2001Assignee: Children's Hospital, Inc.Inventors: Gail E. Besner, Srikumar B. Pillai
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Patent number: 6099567Abstract: A tissue graft composition comprising stomach submucosal tissue delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate is described. The graft composition can be or implanted into a host to replace or support damaged or diseased tissues.Type: GrantFiled: May 4, 1999Date of Patent: August 8, 2000Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Sherry L. Voytik-Harbin, Andrew O. Brightman, Robert S. Tullius
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Patent number: 6096347Abstract: The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition.Type: GrantFiled: May 4, 1999Date of Patent: August 1, 2000Assignee: Purdue Research FoundationInventors: Leslie A. Geddes, Stephen F. Badylak, Robert G. Matheny, William E. Schoenlein, Fred J. Obermiller, William J. Havel
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Patent number: 6054142Abstract: A biocompatible cell device having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule.Type: GrantFiled: August 1, 1996Date of Patent: April 25, 2000Assignee: Cyto Therapeutics, Inc.Inventors: Rebecca Li, Tyrone F. Hazlett
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Antitumor agents isolated from intestinal mucosa, a method for their isolation and their application
Patent number: 6015878Abstract: This invention provides a method for isolating antitumor agents, inhibiting enterocytogenins, from pig intestinal mucosa. It further provides the antitumor agents, which are nucleopeptides. Additionally the invention provides methods for suppressing the growth of certain tumor cells comprising administering an inhibiting enterocytogenin to tumor cells.Type: GrantFiled: October 2, 1997Date of Patent: January 18, 2000Assignee: Alexandrov, Christo AlexandrovInventors: Borislav Borisov Trifonov, Jeorge Konstantinov Roussev, Nikola Atanassov Boshev -
Patent number: 5985592Abstract: In accordance with the present invention, it has been discovered that monocyte conditioned medium (MCM) obtained from patients with liver disease stimulates the proliferation of fibroblasts. Platelet derived growth factor (PDGF) has also been found to stimulate fibroproliferation of fibroblasts, and to be at least partially responsible for the fibroproliferative effect of the MCM. Further in accordance with the present invention, the effect of MCM and PDGF on the expression of c-fos and c-jun has been investigated, because c-fos and c-jun form AP-1 complexes which can stimulate genes involved in proliferation. It has recently been reported that pentoxifylline inhibits platelet derived growth factor-stimulated proliferation. The mechanism of this action of pentoxifylline is unclear. Thus, in the course of the work undertaken as part of the present invention, studies were conducted to determine whether pentoxifylline altered the expression of c-fos and c-jun.Type: GrantFiled: June 5, 1997Date of Patent: November 16, 1999Assignee: Dalhousie UniversityInventor: Theresa C. Peterson
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Patent number: 5968096Abstract: A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.Type: GrantFiled: August 6, 1997Date of Patent: October 19, 1999Assignees: Purdue Research Foundation, Clarian Health PartnersInventors: Bryan Whitson, Boyle Cheng, Stephen F. Badylak
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Patent number: 5955110Abstract: Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip formts an angle of about 180.degree./N with the longitudinal axes of at least two other strips of submucosal tissue.Type: GrantFiled: November 12, 1996Date of Patent: September 21, 1999Assignees: Purdue Research Foundation, Inc., Methodist Hospital of Indiana, Inc.Inventors: Umesh H. Patel, Michael C. Hiles, Bryan A. Whitson, Boyle Cheng, Stephen F. Badylak, Klod Kokini
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Patent number: 5948442Abstract: This patent relates to the obtaining of two pharmaceutical forms--pulvis and ampules of the veterinary medical preparation "Enterogenin". The bioactive ingredient of the preparation is isolated by fractionation of pig small intestinal mucosa cell, extraction with acetic acid, sedimentation with ethyl alcohol, ion-exchange chromatography and diaflo ultrafiltration in the range of 0.5-2 kDa. The bioactivity of the preparation is related to two nucleopeptides: guanosine tripeptide and adenosine heptapeptide. The basic criterion for the biological action of "Enterogenin" pulvis and ampules is the activation of biosynthesis of nucleic acids and specific proteins in the muscles, liver, intestines and spleen.Type: GrantFiled: March 17, 1997Date of Patent: September 7, 1999Assignee: Christo Alexandrov AlexandrovInventors: Borislav Borisov Trifonov, Jeorge Konstantinov Roussev, Nikola Atanassov Boshev, Metodi Stefanov Petrov
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Patent number: 5936063Abstract: The present invention relates to a novel antimicrobial peptide isolated from Bufo bufo gargarizans exhibiting therapeutic antibacterial and antifungal properties.Type: GrantFiled: April 21, 1998Date of Patent: August 10, 1999Assignee: Samyang Genex Co., Ltd.Inventors: Sun-Chang Kim, Chan-Bae Park, Dong-Kyun Lee, In-Cheol Kim, Seung-Suh Hong, Hyun-Soo Lee
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Patent number: 5916555Abstract: The present invention relates to a pharmaceutical composition containing a combination of natural drugs for treatment of diabetes. More specifically, the present invention relates to a composition containing 17 kinds of main natural drugs, i. e. Cordyceps, Bezoar bovis, Carthami flos, Astragali radix, Hirudo, Polygoni cuspidati radix, Polygonati falcati rhizoma, Euonymi lignum suberalatum, Corni fructus, Moutan cortex, Lycii cortex radicis, Lycii fructus, Atractylodis rhizoma alba, Atractylodis rhizoma, Coptidis rhizoma, Puerariae radix and Rehmaniae radix crudae.Type: GrantFiled: October 30, 1997Date of Patent: June 29, 1999Assignee: Sam Chun Dang Pharm Co., Ltd.Inventors: Jung Sik Lee, Chung San Kong, Song Deuk Lee, Kyung Eun Kwak
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Patent number: 5885619Abstract: A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.Type: GrantFiled: September 16, 1997Date of Patent: March 23, 1999Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Umesh H. Patel, Michael C. Hiles, Bryan Whitson, Boyle Cheng, Stephen F. Badylak, Klod Kokini
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Patent number: 5866414Abstract: A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.Type: GrantFiled: September 19, 1995Date of Patent: February 2, 1999Inventors: Stephen F. Badylak, Sherry Voytik, George Boder
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Patent number: 5762966Abstract: A method for surgical repair of a diseased or damaged bladder is described. Diseased or damaged bladder tissue is surgically replaced with submucosal tissue of a warm blooded vertebrate to promote regrowth of endogenous urinary bladder tissue.Type: GrantFiled: January 15, 1997Date of Patent: June 9, 1998Assignees: Purdue Research Foundation, Methodist Hospital of IndianaInventors: Peter M. Knapp, Jr., James E. Lingeman, Robert J. Demeter, Stephen F. Badylak
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Patent number: 5753267Abstract: A tissue graft construct comprising submucosal tissue of a warm-blooded vertebrate and a proliferating population of cells is described. The submucosal graft constructs used in accordance with the present invention induce host tissue proliferation, remodeling and regeneration of appropriate tissue structures upon implantation in a host.Type: GrantFiled: September 19, 1995Date of Patent: May 19, 1998Assignee: Purdue Research FoundationInventors: Stephen F. Badylak, Sherry Voytik
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Patent number: 5711969Abstract: A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.Type: GrantFiled: April 7, 1995Date of Patent: January 27, 1998Assignees: Purdue Research Foundation, Methodist Hospital of IndianaInventors: Umesh H. Patel, Michael C. Hiles, Bryan Whitson, Boyle Cheng, Stephen F. Badylak, Klod Kokini
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Patent number: 5709887Abstract: A biological is used as a therapeutic agent or booster to produce sustained responses in the immune cells against tumors. The biological of the present invention is derived from the pleuroperitoneal organs of a neotenic amphibian, e.g., axolotl, or from the notochord and surrounding tissues of an Agnathan, e.g., Lamprey eel, or from mesenteries and visceral organs from the pleuroperitoneal cavity of older fetuses or baby vertebrates from fish to humans, or from tadpoles of frogs at the stage when both the tail and the four legs are present, i.e., just before completion of the metamorphosis period.Type: GrantFiled: June 6, 1995Date of Patent: January 20, 1998Inventors: Clifford R. Bryan, deceased, by Marguerite Bryan, administratrix
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Patent number: 5645860Abstract: A method for surgical repair of a diseased or damaged bladder is described. Diseased or damaged bladder tissue is surgically replaced with submucosal tissue of a warm blooded vertebrate to promote regrowth of endogenous urinary bladder tissue.Type: GrantFiled: April 16, 1996Date of Patent: July 8, 1997Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Peter M. Knapp, Jr., James E. Lingeman, Robert J. Demeter, Stephen F. Badylak
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Patent number: 5641518Abstract: A method for repairing damaged or diseased bone is described. The method comprises the step of implanting into the damaged or diseased region a bone graft composition in powder form, the composition comprising the tunica submucosa delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa of a segment of vertebrate intestine.Type: GrantFiled: February 10, 1995Date of Patent: June 24, 1997Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Stephen F. Badylak, Sherry Voytik
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Patent number: 5573784Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.Type: GrantFiled: April 18, 1995Date of Patent: November 12, 1996Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
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Patent number: 5516533Abstract: A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.Type: GrantFiled: November 22, 1994Date of Patent: May 14, 1996Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.Inventors: Stephen F. Badylak, Robert J. Demeter, Michael Hiles, Sherry Voytik, Peter M. Knapp, Jr.
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Patent number: 5491284Abstract: A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.Type: GrantFiled: December 17, 1993Date of Patent: February 13, 1996Assignee: Anticancer IncorporatedInventors: Ann Monosov, Xinyu Fu
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Patent number: 5470574Abstract: A compound of general formula, in substantially pure form, wherein A is a cation. A method for preparation is also disclosed, together with compositions and methods of use thereof.Type: GrantFiled: December 20, 1993Date of Patent: November 28, 1995Assignee: J. W. Broadbent Nominees Pty. Ltd.Inventors: Takuo Kosuge, Kuniro Tsuji, Hitoshi Ishida, Yoshiki Kosuge
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Patent number: 5445957Abstract: This invention relates to a beta-fructofuranosidase enzyme food supplement composition, which alleviates gastrointestinal distress caused by ingested food containing oligosaccharides, comprising a beta-fructofuranosidase enzyme, a cellulase enzyme and a hemicellulase enzyme. More particularly, the enzyme food supplement composition of this invention comprises a beta-fructofuranosidase enzyme, a cellulase enzyme, a hemicellulase enzyme, a lipase enzyme and an acid protease enzyme. This invention also relates to a method of alleviating gastrointestinal distress in the gastrointestinal system of a human being, which distress is caused by ingested food containing oligosaccharides, the method comprising the step of ingesting a beta-fructofuranosidase enzyme food supplement composition comprising a beta-fructofuranosidase enzyme, a cellulase enzyme and a hemicellulase enzyme, to convert oligosaccharides contained in the ingested food to reducing sugars.Type: GrantFiled: December 5, 1994Date of Patent: August 29, 1995Assignee: Triarco Industries, Inc.Inventors: Rodger R. Rohde, Jr., Edward F. Schuler, Richard A. Handel