Abstract: A pharmaceutical preparation for oral or transdermal treatment of wounds, damaged tissue and inflammation which is a solution containing water and metallic trace elements or salts thereof in a physiological quantity.
Abstract: The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions.
Type:
Grant
Filed:
August 16, 1988
Date of Patent:
October 8, 1991
Assignee:
Advanced Magnetics, Inc.
Inventors:
Jerome M. Lewis, Edward T. Menz, Francis E. Kenny, Ernest V. Groman, Lee Josephson
Abstract: A method and contrast agent for magnetic resonance imaging (MRI) of abscess. Granulocytes are separated from whole blood and incubated with an imaging vehicle such as magnetite. The granulocytes encapsulate the imaging vehicle and are suspended in an intravascularly administrable carrier to form the contrast agent. The contrast agent is highly specific for MRI of abscess.
Abstract: The mineral composition is useful for treatment of blood acidosis, peritoneal ascites and anemia. It is a combination of particulate wood ash and calcium carbonate.
Abstract: New uses for the Oak Poison Preventive supplement, including the treatment of feline leukemia, shipping fever in cattle, and increased wool production in sheep.
Abstract: Nutritional mineral supplements comprise iron compounds and calcium compounds in combination with citrates or tartrates, ascorbates, and, optionally, fructose. The tendency of calcium to inhibit the bioavailability of iron is reduced in such compositions, so that conjoint bioavailability of these two important minerals is enhanced.
Abstract: Oxy-iron compounds are useful for the treatment and prevention of hyperphosphatemia. Such compounds, particularly those exhibiting high surface area, can be administered orally to bind and inhibit absorption of dietary phosphate, or such compounds can be contacted with the dialysate in a hemodialysis unit to enhance reduction of serum phosphate of patients undergoing hemodialysis.
Abstract: A composition for the treatment of psoriasis and other skin diseases comprising a salt mixture of defined purity, which is applied to the diseased skin in solution or in gelled form. The composition may be characterized as composed primarily of a mixture of a magnesium halide, such as magnesium chloride, with mixed alkali and alkaline earth metal salts such as sodium and potassium chloride and/or bromide and calcium chloride or bromide. Other cations present in the mixture include strontium, aluminum, iron, lithium and zinc, and the anions include sulphate, hydrogen carbonate, borate, fluoride, silicate, iodide and carbonate.
Abstract: Iron proteinaceous derivatives, obtained from ferric or ferrous salts and lysozyme with glutaric or 1,2-cyclohexanedicarboxylic anhydride and their pharmaceutical use in the oral treatment of iron-deficiency anemia, are described.
Abstract: A method is disclosed for reducing the propensity of a dairy cow to develop severe milk fever upon calving comprising administering thereto a composition comprising a water-soluble calcium compound and a complexing agent for serum phosphorus.
Abstract: This disclosure describes novel 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-4-amines useful as intermediates for the preparation of animal growth regulants.