Abstract: Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

Abstract: Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.

Abstract: This invention concerns nutritive and restorative hair care compositions which are distinctive in that they contain probiotic bacteria and other ingredients found in yogurt. Both water-based and anhydrous embodiments are described. The compositions are designed to moisturize, soften, condition, straighten, strengthen and repair hair in addition to promoting a healthy scalp.

Abstract: Compositions are provided comprising a macrolide T-cell immunomodulator or immunosuppressant agent, e.g. pimecrolimus, and at least one anti-photoaging agent such as a sunscreen, an anti-oxidant or a DNA-repair enzyme. They are useful in particular in the curative treatment or prevention of dermatological diseases and of conditions where it is desired to inhibit the skin aging effects of light radiation such as UV-A and UV-B light, e.g. development of skin cancer.

Abstract: The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as scleroderma, its various manifestations, skin aging or loss of hair.

Abstract: The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

Abstract: The present invention relates to the use of IL-15 polynucleotides, polypeptides or compounds which bind to an antibody which specifically recognizes the IL-15 polypeptide or which specifically bind to an IL-15 receptor alpha chain for the preparation of a composition for stimulating hair growth or for treating, preventing and/or ameliorating hair loss. Moreover the present invention encompasses a transgenic non-human animal comprising an IL-15 polynucleotide. The present invention also relates to a method for stimulating hair growth in a non-human animal and to methods for manufacturing animal hair. Finally, the present invention relates to a method of treating, preventing and/or ameliorating a subject which suffers from hair loss.

Abstract: Methods for the prevention and treatment of skin damage arising from the exposure to UV radiation, air pollution and other stressors capable of leading to the formation of free radicals, using the small-dithiol protein glutaredoxin in a dermatologically acceptable carrier that can be applied topically are disclosed. Some embodiments may include other proteins such as superoxide dismutase and/or catalase, as well as other antioxidant molecules such as reduced glutathione, vitamin E, vitamin C, lycopene, astaxanthin and/or tocotrienols.

Abstract: An exfoliation composition comprising a protease activator such as a chestnut extract, at least one exfoliator and a cosmetically acceptable vehicle, and methods of use thereof.

Abstract: Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Diblock and triblock peptide-based body surface coloring reagents formed by coupling a body surface binding peptide to a pigment binding peptide, either directly or through a spacer, are described. The peptide-based body surface coloring reagents may be used in conjunction with pigments to color body surfaces.

Abstract: A topical composition having (i) an isolated polypeptide having the sequence of SEQ ID NO: 1 or a functional equivalent thereof, and (ii) a cosmetically acceptable carrier; and use thereof.

Abstract: The invention concerns the use of an oyster enzymatic hydrolysate of oyster flash hydrolyzed by a protease as a cosmetic composition.

Abstract: The present invention relates to a composition for treating acne comprising an anti-microbial peptide made from the amino acids phenylalanine, alanine, leucine and lysine with said peptide admixed with salicylic acid and/or salicylate salts in a cosmetic delivery vehicle containing a rehydrating polymer. The invention further relates to a method for treating acne by topically administering one of the compositions in an amount therapeutically effective to reduce the redness and blemishes associated with acne.

Abstract: Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fibers.

Abstract: The present invention relates to methods for enhancing the result of a skin treatment for a human patient. In some embodiments, the methods comprise the step of administering a neurotoxin to a skin area designated for the skin treatment. The skin treatment includes the application of a dermatologic agent and/or procedure.

Abstract: A non-oxidative hair coloring composition, comprises yogurt or yogurt-derived material. The invention also provides a method of improving the coloring effects of non-oxidative hair coloring compositions, comprising application to the hair (during or after dyeing) of yogurt or a yogurt-derived material. The invention also covers use of yogurt or yogurt-derived material in a hair care composition for the purpose of improving the coloring effects of a non-oxidative hair dye. The invention can be put into effect by incorporating yogurt or yogurt-derived material into a hair care composition for use during non-oxidative dying of hair (i.e. a non-oxidative hair coloring composition) where it acts to improve dye deposition onto hair, or into a composition for use on hair after dyeing by a non-oxidative method, e.g. a shampoo or conditioner composition, to help maintain the color of dyed hair.

Abstract: Microencapsulated delivery vehicles comprising an active agent are disclosed. In one embodiment, the microencapsulated delivery vehicles are heat delivery vehicles capable of generating heat upon activation. The microencapsulated heat delivery vehicles may be introduced into wet wipes such that, upon activation, the wet wipe solution is warmed resulting in a warm sensation on a user's skin. Any number of other active ingredients, such as cooling agents and biocides, can also be incorporated into a microencapsulated delivery vehicle.

Abstract: Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

Abstract: Compositions comprising one or more polymeric suds volume and suds duration enhances which are mild on the user's skin. The polymeric suds enhances are suitable for use in methods which in use as compositions light duty liquid, LDL compositions, hand dishwashing compositions, laundry bars, personal cleansing compositions and the like.

Abstract: Compositions, optionally heat-activated, methods and kits for lanthionizing keratinous fibers to achieve relaxation of said keratinous fibers comprising applying to keratinous fibers a composition comprising at least one hydroxide compound and at least one reducing agent chosen from thiols, sulfites, and derivatives thereof, and heating the keratinous fibers.

Abstract: A hair bleach mixture obtained by combining an aqueous oxidizing agent composition and a persulfate composition comprising at least one hydrophobically modified particulate, said hydrophobically modified particulate being present in the mixture in an amount sufficient to reduce diffusion and/or migration of the mixture from the hair strands to which it is applied; and a method and kit for bleaching hair.

Abstract: A new and improved aqueous shaving cream composition and method of using the composition is disclosed. The aqueous composition comprises citric acid, hair keratin amino acids, stearic acids, boric acid, fumaric acid, SD Alcohol 40, cetyl alcohol, stearyl alcohol, calcium chloride, sodium chloride, camphor, hydroxyethylcellulose, calcium hydroxide, ammonium hydroxide, triethanolamine, gelatin, stearamidopropyl dimethylamine, methylchloroisothiazolone, methylisothiazolinone, cyclopentasiloxane, glycerin, dimeticonol, linseed oil, soybean oil, eucalyptus oil, propylene glycol, fragrance, methol, guar gum, DMDM hydantoin, sodium calcium alginate, panthenol, oleyl sarcosine, methylparaben, stearyl octyldimonium methosulfate, behenamidopropyl ethyldimonium ethosulfate, TEA-dodecylbenzenesulfonate, calcium sulfate, and disodium EDTA. The method of using the aqueous composition comprises the steps of getting, moistening, obtaining, placing, rubbing, shaving, and wiping.

Abstract: Cationic polyurethanes and polyureas formed from (a) at least one diisocyanate or reaction product thereof with one or more compounds containing two or more active hydrogen atoms per molecule, and (b) at least one diol, primary or secondary amino alcohol, primary or secondary diamine or primary or secondary triamine each with one or more tertiary, quaternary or protonated tertiary amine nitrogen atoms and having a glass transition temperature of at least 25° C. and an amine number of from 50 to 200, based on the non-quaternized or -protonated compounds, or other salts of these polyurethanes and polyureas, are useful as ingredients of cosmetic and pharmaceutical preparations.

Abstract: The present invention is directed to a treatment for animal pruritus. One aspect of this invention involves a treatment for animal pruritus comprising one or more polypeptides with an amino acid sequence including KPV (SEQ ID NO: 1), VKP-Ac-CC-Ac-KPV (SEQ ID NO: 5), MEHFRWG (SEQ ID NO: 2), HFRWGKPV (SEQ ID NO: 3) or SYSMEHFRWGKPV (SEQ ID NO: 4) for animal pruritus caused by exposure to any number of agents or causes. The polypeptides are at a level to effectively treat the animal pruritus and are combined with a shampoo. Other combinations include the polypeptides at a level to effectively treat animal pruritus combined with a shampoo and an antibiotic, antifungal and/or and anti-inflammatory. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above.

Abstract: The present invention is directed to a treatment for animal pruritis. One aspect of this invention involves a treatment for animal pruritis comprising one or more polypeptides with an amino acid sequence KPV (SEQ ID NO:1), VPK-AC-CC-AC-KPV, HFRWGKPV (SEQ ID NO:3), SYSMEHFRWGKPV (SEQ ID NO:4) for animal pruritis caused by exposure to any number of agents or causes. The polypeptides are at a level to effectively treat the animal pruritis and are combined with a shampoo. Other combinations include the polypeptides at a level to effectively treat animal pruritis combined with a shampoo and an antibiotic, antifungal and/or and anti-inflammatory. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above.

Abstract: The present invention relates to detergent compositions comprising polymeric suds volume and suds duration enhancers. These polymeric materials provide enhanced suds volume and suds duration during cleaning.

Abstract: To provide an emulsifier for cosmetic use which not only has improved emulsifying power and feel during use, but wherein the emulsifier itself has a skin cell growth-promoting property.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer or a water-soluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer. The composition also includes a second water-swellable, water-insoluble polymer that provides for a phase separating film forming composition. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening, and removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: Provided are compositions comprising monoethanolamine salts of thioglycolic, salicylic, lactic and glycolic acids in combination with an organic enzyme, preferably papain, and an oxidizing aged their methods of use to induce hair growth in the scalp of humans and other mammals.

Abstract: The present invention relates, firstly, to a cosmetic and/or dermatological composition intended for treating keratin fibres, in particular human keratin fibres and more particularly human hair, comprising, in a support which is suitable for keratin fibres: (a) at least one enzyme of 2-electron oxidoreductase type in the presence of at least one donor for the said enzyme; (b) at least one substantive polymer chosen from the group consisting of: (i) cationic cellulose derivatives; (ii) dimethyidiallylammonium halide homopolymers and copolymers of dimethyidiallylammonium halide and of (meth)acrylic acid; (iii) methacryloyloxyethyltrimethylammonium halide homopolymers and copolymers; (iv) polyquaternary ammonium polymers; (v) vinylpyrrolidone polymers containing cationic units; (vi) mixtures thereof. The present invention also relates to processes for treating keratin fibres, in particular processes for dyeing, permanently reshaping or bleaching the hair using this composition.

Abstract: A method of identifying a hair growth modulator (i.e., hair growth inhibitor or inducer) which comprises identifying a P-cadherin modulator (i.e., P-cadherin inhibitor or inducer); and testing whether the P-cadherin modulator is functional as a hair growth modulator.

Abstract: Method of improving the skin feel or mildness to the skin of various detergent compositions, such as hand dish washing compositions, hand laundry bars, shampoos and other personal cleansing compositions.

Abstract: This invention relates to a novel ion-pair delivery system useful for gender and ethnic background selective hair care and nail care applications in which an electron donor composition and an electron acceptor composition, or a proton donor composition and a proton acceptor composition, or an anionic and a cationic composition, are combined synergistically. The bioavailability, deposition, functional performance, and consumer aesthetics of the compositions thus combined in such ion-pairs are enhanced synergistically. Hair care compositions, such as shampoo, conditioner, hair lotion, hair oil, hair gel, hair sheen, hair rinse, hair balm, hair wax, hair spray, and such, and nail care compositions, such as nail enamel, nail creams, nail serums, nail lacquers, nail spray, and nail polish, and such, can thus be obtained with synergistically enhanced performance.

Abstract: The invention relates to novel amphiphilic complexes, a method for their preparation, and the compositions containing them. Said amphiphilic complexes result from the reaction, at a temperature between ambient temperature and 80° C., between a protein or polypeptide whose average molecular mass is greater than or equal to 5,000 Daltons and a fatty chain whose carbon atom number is between 4 and 30 selected from fatty acid, fatty alcohol, fatty amine, with the exclusion of undecylenic acid ; the protein or polypeptide/fatty chain weight ratio ranging from 1000/1 to 1/10.

Abstract: This invention relates to improved compositions and methods for treating skin conditions containing sebum reduction agents; keratolytic agents and anti-inflammatory agents that results in unexpectedly superior control of skin conditions such as acne.

Abstract: The object of the present invention is to elucidate a biologically active function of a component constituting undegraded sericin and to provide a novel medical material, cosmetic material, etc. utilizing the functional composition. Disclosed is a cell growth promoter obtainable by elution from a fiber discharged by a domestic silkworm, e.g., cocoon filaments or the like, wherein the cell growth promoter comprises sericin having a molecular weight of about 400,000 as measured by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) as a main component. This cell growth promoting agent (substance) is extremely useful because growth of cells is promoted when it is used in a wound dressing material, a vascular endothelium forming material and an organ forming material for medical use, in a cell culture base material for biological use, or in a cosmetic material for skin care use.

Abstract: A method for stimulating cell growth includes administrating to a candidate a sponge protein hydrolysate which is a product by acidic hydrolysis of sponge skeleton fibers (spongin fibers) obtained from refined sponges as the raw material. The product has (i) a molecular weight of less than 5,000, with light coloring, and (ii) a human cell growth stimulating activity. The above substances can be used in the form of food product materials, pet food materials, cosmetics or medicinal products to reduce wrinkles and protect the hair cuticles.

Abstract: The present invention is directed to a novel progression of topical and oral administration or use of lactoferrin or lactoferrin and other biological ingredients to prevent and treat dermatological conditions or disorders in humans. More specifically, the present invention is directed to the administration of lactoferrin in a topical material such as an ointment or cream to the skin of humans and also including a oral administration, together the topical and oral administration has a synergetic effect in the treatment of the skin. The progression of medicaments of the present invention are: 1) lactoferrin; 2) lactoferrin and conjugated linoleic acids; 3) lactoferrin, a plant or animal derived lipid and oblepicha; 4) lactoferrin, a plant or animal derived lipid, oblepicha, and an omega fatty acid; and 5) lactoferrin, a plant or animal derived lipid, oblepicha, an omega fatty acid and a whey protein.

Abstract: The present invention describes a method for targeted and specific delivery of beneficial compounds, including hair dyes, melanin, proteins, and nucleic acids for gene therapy, to hair follicle cells using liposomes encapsulating the beneficial compound. Particularly preferred methods describe delivery of hair dyes, melanin or tyrosinase to the hair follicle for the purpose of improving hair color or condition, the delivery of compounds which prevent alopecia or stimulate hair growth, either by encapsulating a compound in liposomes, or by encapsulating a nucleic acid capable of expressing a protein in liposomes. Also described are liposome compositions for practicing the methods.

Abstract: A hair treatment agent, a shampoo or a hair coloring agent comprising a silylated peptide-silane compound copolymer composition which is produced by the following process and has viscosity in a range from 500 to 20000 mPa.s in 70% of solid content concentration of said copolymer composition at 20° C.

Abstract: The present invention provides compositions comprising an essential oil, methods for preparing the compositions, and methods of disinfecting potable liquid with the compositions.

Abstract: Provided are a dispersion comprising organic-inorganic hybrid type particles carried thereon with a biologically active substance, wherein the above particles can be obtained by allowing a block copolymer represented by Formula (I):

Abstract: The present invention is concerned with preparations for application to human skin including a cream or lotion base together with a quantity of a skin-tightening agent consisting essentially of gliadin. Products such as creams, lotions, facial masks and sunscreens can be prepared which exhibit desirable skin-tightening or anti-wrinkle effects.

Abstract: Administration forms for application to the skin or mucosa, comprising a carrier matrix and at least one active substance, are characterized in that the carrier matrix has a plurality of particles having open pores or containing capillary spaces, said particles serving as active substance reservoir and containing at least one active substance.

Abstract: Cosmetic or dermatological composition characterized in that it comprises an association between an elastase inhibiting compound of the N-acylaminoamide family and at least one compound for reducing hair loss and/or enhancing hair regrowth.

Abstract: The present invention provides a method of sustaining the rate of heat felt on the skin as a result of an exothermic reaction between a combination of an unencapsulated and an encapsulated catalase, and peroxide. The catalase component provides a sustained heat release and in combination with other non-catalase heat-generating agents, the rate of heat released and felt on the skin can be further controlled. The compositions of the present invention also soften the skin and contribute to the health of the skin by reducing the presence of oxygen free radicals on the skin surface.

Abstract: A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.

Abstract: A topical skin care product formula having a beneficial effect on the user's face and/or neck skin and appearance. The formula can be used for preparation of a skin cream and/or skin serum to be rubbed into the skin and/or a liquid to be applied to a pad and placed on the face and/or neck for a few minutes.

Abstract: The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.

Abstract: The invention relates to a method for the identification and/or production of an inhibitor of hair production. Moreover, the invention relates to a method for the inhibition of hair production. The invention also relates to a method for the production of a pharmaceutical composition. Furthermore, the invention relates to a pharmaceutical composition comprising an inhibitor of hair production identified or obtained according to one of the methods of the invention or a polynucleotide coding for the inhibitor, optionally in a pharmaceutically acceptable form of administration. The invention also relates to a pharmaceutical composition which comprises a polypeptide comprising the DNA-binding domain but not the transactivator domain of Whn, LEF-1 or Hoxc13, or a polynucleotide coding for said polypeptide, optionally in a pharmaceutically acceptable form of administration.