Microcapsule With Fluid Core (includes Liposome) Patents (Class 428/402.2)
  • Patent number: 11920043
    Abstract: The present invention relates to a method of manufacturing non-sintered liquid metal ink, and more particularly, to a method of manufacturing liquid metal ink manufactured without a sintering process. The method of manufacturing liquid metal ink according to an embodiment of the present invention includes: (a) inputting a solvent into liquid metal in a container at room temperature; (b) performing oxide film-removing treatment on the liquid metal of step (a); and (c) dispersing the liquid metal that has undergone step (b) in a form of nanoparticles through ultrasonic treatment.
    Type: Grant
    Filed: December 24, 2021
    Date of Patent: March 5, 2024
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyoung Soo Kim, Kwang Seok Park, Jeong Su Pyeon, Hye Jun Jeon
  • Patent number: 11865190
    Abstract: Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.
    Type: Grant
    Filed: September 9, 2022
    Date of Patent: January 9, 2024
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Blair Leavitt, Pieter Cullis, Terri Petkau, Austin Hill, Pamela Wagner, Jayesh Kulkarni
  • Patent number: 11666534
    Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: June 6, 2023
    Assignee: GlaxoSmithKline Biologicals SA
    Inventor: Andrew Geall
  • Patent number: 11547651
    Abstract: A skin care, wound care, or oral care device, comprising an essential oil stabilized into a polymerizable substance.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: January 10, 2023
    Assignee: Alira Health Boston LLC
    Inventor: Mitchell Corey Sanders
  • Patent number: 11496014
    Abstract: A winding head arrangement for an electric rotating machine includes a base body including an electrically conductive material having an electrically insulating coating, and a plurality of conductors made from a first metal material and connected to the base body via the electrically insulating coating by a first additive production method.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: November 8, 2022
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Karsten Brach, Jens Dahl Jensen, Hartmut Rauch, Olaf Rehme, Jakob Schneck, Oliver Stier
  • Patent number: 11406570
    Abstract: A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: August 9, 2022
    Assignee: Premier Dental Products Company
    Inventors: Stephen M. Gross, William A. McHale, Mark A. Latta
  • Patent number: 11339503
    Abstract: A network of microfibers are fabricated with a core-shell construction from sustainable materials, where the core includes a phase-change material, such as coconut oil, and the shell includes a biomass, such as cellulose. The microfibers are made via a wet-wet electrospinning process utilizing a coaxial spinneret with an inner conduit and an outer conduit. The biomass and the phase-change material are coaxially extruded into a coagulation bath including a mixture of ethanol and water. The collected microfibers exhibit a beaded structure of PCM aggregates and biomass connecting regions between the aggregates and are effective to aid in the thermoregulation of the immediate environment surrounding the network. The microfibers are suitable for use in a variety of sustainable products such as wearable thermoregulating textiles, wall/ceiling panels, insulation, packaging material, and more.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: May 24, 2022
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Ranodhi Nilochani Udangawa, Charles Frederick Willard, Chiara Diamante Mancinelli, Caitlyn A. Chapman, Robert John Linhardt, Trevor John Simmons
  • Patent number: 11305252
    Abstract: An ultra low density film and an ultra low density solid material are produced by the steps of providing a vessel, introducing two immiscible fluids into the vessel, adding nanocrystals to at least one of the two immiscible fluids, applying a shear force to the two immiscible fluids and the nanocrystals in a manner that causes the nanocrystals to self-assemble and form colloidosomes. The colloidosomes amass and evaporation of the two fluids produces dried colloidosomes. The ultra low density self-assembled colloidosomes are hollow self-assembled colloidosomes, which are formed into the ultra-low density film and the ultra-low density solid.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: April 19, 2022
    Assignees: Lawrence Livermore National Security, LLC, Carnegie Mellon University
    Inventors: Christine A Orme, Sarah Baker, Yixuan Yu, Shelley L Anna, Charles Sharkey
  • Patent number: 11224566
    Abstract: A composition comprising, in a physiologically acceptable medium, a crosslinked hyaluronic acid (HA), having a degree of modification less than 1.9 mole %; a HA with a molecular weight of about 50 kDa or less; and/or an agent stimulating endogenous HA synthesis. Also disclosed is a cosmetic use of such composition in skin care and/or anti-ageing treatment.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 18, 2022
    Assignee: Galderma Holding SA
    Inventors: Claire Mallard, Yves Rival
  • Patent number: 11225626
    Abstract: Phase change material compositions and methods for using the compositions to prepare substrate coatings or bulk blended polymers that advantageously lower friction between interacting substrate surfaces and lower substrate surface wear.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: January 18, 2022
    Assignee: The Texas A&M University System
    Inventors: Reza Gheisari, Andreas A. Polycarpou
  • Patent number: 11141731
    Abstract: This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: October 12, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Darren Roy Link, Manuel Marquez-Sanchez, Zhengdong Cheng
  • Patent number: 11111327
    Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: September 7, 2021
    Assignee: Alcon Inc.
    Inventors: Ryan DeSousa, Troy Vernon Holland, Frank Chang
  • Patent number: 11066316
    Abstract: A method for treating an oil-containing medium including oil or grease or both oil and grease includes the steps of combining algae with an oil-containing medium and allowing the algae to engulf or uptake at least a portion of the oil or grease in the oil-containing medium. A mixture for treating oil or grease or both oil and grease includes an oil-containing medium including oil or grease or both oil and grease and phagotrophic algae that engulf or uptake at least a portion of the oil or grease in the oil-containing medium.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: July 20, 2021
    Assignee: The University of Akron
    Inventors: Lu-Kwang Ju, Majid Hosseini
  • Patent number: 11045414
    Abstract: A topical mosquito control product includes active and inert ingredients. The active ingredients include natural materials and may include soybean oil, geraniol, cinnamon oil and cedar wood oil. The inert ingredients include natural materials and may include bee's wax, isopropyl alcohol, sunflower oil, salt, triethyl citrate and water.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: June 29, 2021
    Assignee: Penta 5 USA, LLC
    Inventors: R. Charles Murray, John Harlin
  • Patent number: 11007500
    Abstract: Methods of inducing or controlling particle motion in suspensions and colloids are described. In one aspect, a method of inducing particle motion in a suspension comprises contacting the suspension with a gas phase to establish at least one interface between the gas phase and continuous phase of the suspension. One or more gases of the gas phase are transferred across the interface to provide a solute gradient in the continuous phase, the solute gradient inducing motion of the suspended particles.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 18, 2021
    Assignee: The Trustees of Princeton University
    Inventors: Orest Shardt, Sangwoo Shin, Suin Shim, Patrick B. Warren, Howard A. Stone
  • Patent number: 10905156
    Abstract: The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable. A breakable seamless capsule for a smoking equipment, comprising a content containing an oily ingredient and a capsule shell for encapsulating said content, wherein: the capsule shell contains a polysaccharide; the thickness of the capsule shell is 60 ?m or more; the volatilization content (VC) of the content after leaving the content to stand under an environment at a temperature of 25° C. and a relative humidity of 40% for 4 hours is 3.0 wt % or more with respect to the total weight of the encapsulated content; and the crush strength per diameter of the capsule is 3-8 N/mm.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: February 2, 2021
    Inventor: Kenichi Koyama
  • Patent number: 10906258
    Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: February 2, 2021
    Assignee: Alcon Inc.
    Inventors: Troy Vernon Holland, Frank Chang, Ryan DeSousa
  • Patent number: 10758458
    Abstract: A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: September 1, 2020
    Assignee: Premier Dental Products Company
    Inventors: Stephen M. Gross, William A. McHale, Mark A. Latta
  • Patent number: 10675624
    Abstract: The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: June 9, 2020
    Assignee: University of Maryland, College Park
    Inventors: Ian M. White, Srinivasa Raghavan, Kunal R. Pandit
  • Patent number: 10667512
    Abstract: The present invention relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions. The compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: June 2, 2020
    Assignees: Eden Research PLC, Cornell University
    Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff, Gary Harman
  • Patent number: 10597798
    Abstract: In one aspect, the disclosure relates to composite fibers having a structure comprising a core component and sheath component, wherein each of the core component and the sheath layer independently comprise a polymer and a disclosed cooling composition. In various further aspects, the present disclosure pertains to single-covered yarn comprising a core yarn comprising a disclosed composite fiber comprising a core component and a sheath component. In still further aspects, the present disclosure pertains to a fabric, such as a denim fabric, comprising a disclosed single-covered yarn. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 24, 2020
    Assignee: Brrr! Inc.
    Inventors: Hung-Yuan Su, Ying-Pin Wei
  • Patent number: 10537503
    Abstract: A microcapsule composition is provided, which contains a polyurea or polyurethane microcapsule, an alkylnaphthalenesulfonate formaldehyde condensate, and polyvinylpyrrolidone. Also disclosed is a process of preparing the microcapsule composition and a consumer product having such a microcapsule composition.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 21, 2020
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Yabin Lei, Li Xu, John Brahms
  • Patent number: 10499639
    Abstract: A herbicidal composition comprising an aqueous suspension of microcapsules is provided. The microcapsules have a capsule wall of a porous condensate polymer, wherein the microcapsules contain a solution of clomazone in a solvent system comprising one or more non-edible oils. A method for preparing the composition comprises providing a water immiscible phase comprising clomazone, an isocyanate and optionally an ACD cross-linker, dissolved in a solvent system comprising a non-edible oil; providing an aqueous phase comprising one or more surfactants; combining the water immiscible phase and the aqueous phase to form a dispersion of the water immiscible phase in the aqueous phase; thereby forming microcapsules of polyurea containing droplets of the water immiscible phase; and curing the microcapsules.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: December 10, 2019
    Assignee: JIANGSU ROTAM CHEMISTRY CO., LTD.
    Inventors: James Timothy Bristow, Yifan Wu
  • Patent number: 10485739
    Abstract: High strength, high integrity microcapsules containing a hydrophobic core material wherein said microcapsule walls are formed of copolymers of select monomers through a multistep oil-in-water emulsification polymerization process.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: November 26, 2019
    Assignee: ENCAPSYS LLC
    Inventors: Nianxi Yan, Biao Duan, Linsheng Feng
  • Patent number: 10435481
    Abstract: The present invention relates to a regenerated cellulose fiber having a multi-limbed cross-section. The fiber according to the invention is characterized in that the cross-section is formed of at least two multi-limbed basic shapes (1?, 2?, 3?, 4?), which basic shapes are connected, in each case at least at one of their limb ends, to the limb end of another basic shape and the length of the connecting limb (12) resulting from the connection of the two limb ends is longer than the length of the shortest one of the other limbs by a factor of at least 1.5, preferably of from 1.5 to 2.0.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: October 8, 2019
    Assignee: KELHEIM FIBRES GMBH
    Inventors: Ingo Bernt, Konrad Brunner, Matthew North, Reinhold Röthenbacher, Walter Roggenstein, Roland Scholz
  • Patent number: 10342748
    Abstract: The invention relates to stable dispersions, containing (a) 50 to 80% by weight of perfume oils, (b) 10 to 30% by weight of encapsulated fragrances, (c) 0.01 to 0.1% by weight of non-ionic polymers of the type of hydrophobically modified hydroxylalkyl guar compounds, with the proviso that the constituents together with water and optionally other typical auxiliary agents and additives add up to 100% by weight.
    Type: Grant
    Filed: February 14, 2016
    Date of Patent: July 9, 2019
    Assignee: Symrise AG
    Inventors: Jörg Dröge, Jörn Wiedemann
  • Patent number: 10343185
    Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution comprises cationic materials. The cationic materials comprise a polymer, a colloidal particle, a nanoparticle, a nitrogen-rich molecule, a geopolymer, a carbon-based filler, or any combinations thereof. The method also includes agitating the substrate. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a layer comprising the anionic layer and the cationic layer. The anionic solution comprises a layerable material.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 9, 2019
    Assignee: The Texas A&M University System
    Inventors: Jaime C. Grunlan, Tyler C. Guin
  • Patent number: 10293325
    Abstract: According to various aspects and embodiments, core-shell particles and methods of making the same are disclosed. The core-shell particles may include a liquid metal core, at least one layer of inorganic material surrounding the liquid metal core, and at least one layer of organic material attached to the at least one layer of inorganic material.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: May 21, 2019
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Martin Thuo, Ian Tevis
  • Patent number: 10251839
    Abstract: Novel lipid vesicle compositions comprising lipids derived from olive oil fatty acids known as olivates, methods of their preparation, and methods of their use in cosmetics, food, dermatologics, and pharmaceuticals.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: April 9, 2019
    Assignee: IGI Laboratories, Inc.
    Inventors: Nadya Lawrence, Rosemarie Lorenzo
  • Patent number: 10130710
    Abstract: An object is to provide a formulation that includes a particle containing an active ingredient and a surfactant, and a base, and is more excellent in storage stability. For solution, a formulation including a particle containing an active ingredient and a surfactant, and a base, in which the surfactant is contained in a ratio of 5 to 100 parts by weight based on 1 part by weight of the active ingredient, is provided.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: November 20, 2018
    Assignee: SEKISUI CHEMICAL CO., LTD.
    Inventors: Takayuki Akamine, Kazushi Itou, Saori Tone, Yoshiko Abe
  • Patent number: 10034903
    Abstract: To provide a bacterium-based microrobot which can be specifically targeted to cancer in vivo, the present invention provides a drug delivery system for cancer tissue, comprising a bacterium, and a microbead encapsulated with at least one drug, wherein biotin is bound to a surface of the bacterium and a surface of the microbead is coated with streptavidin.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: July 31, 2018
    Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Suk Ho Park, Jong Oh Park, Sung Jun Park, Seong Young Ko, Jung Joon Min, Seung Hwan Park
  • Patent number: 10032955
    Abstract: A quantum dot having core-shell structure, including a core formed of ZnOzS1-z of wurtzite crystal structure of hexagonal crystal system; a first shell covering the core, and formed of AlxGayIn1-x-yN of wurtzite crystal structure of hexagonal crystal system; and a second shell covering the first shell, and formed of ZnOvS1-v of wurtzite crystal structure of hexagonal crystal system. At least one of v, x, y, and z is not zero and is not one; differences between the lattice constants along a-axis of the core, the first shell and the second shell are not greater than 1%; and the core, the first shell and the second shell form band offset structure of type II.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: July 24, 2018
    Assignee: STANLEY ELECTRIC CO., LTD.
    Inventors: Takuya Kazama, Wataru Tamura, Yasuyuki Miyake
  • Patent number: 10005936
    Abstract: A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimeter. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: June 26, 2018
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: W. J. Terry Steele, Vladislav Papper, Robert S. Marks
  • Patent number: 9999704
    Abstract: The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: June 19, 2018
    Assignee: University of Massachusetts
    Inventors: Jie Song, Jing Zhang
  • Patent number: 9968096
    Abstract: More particularly, the present invention relates to a process for producing antimicrobial core-shell microcapsules with immobilized silver particles into and onto the shell. The latter can be used in home or personal care products for delivering a perfuming and malodor-countering effect. The microcapsules obtainable by such a process and the consumer products comprising these microcapsules are also objects of the invention.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 15, 2018
    Assignee: Firmenich SA
    Inventors: Huda Jerri, Marlène Jacquemond, Brian MacDougall
  • Patent number: 9968120
    Abstract: Disclosed are homogenized formulations that comprise microcapsules, wherein the microcapsules comprise an agglomeration of primary microcapsules and a loading substance, where each individual primary microcapsule has a primary shell, and the loading substance is encapsulated by the primary shell, and wherein the agglomeration is encapsulated by an outer shell. Also, disclosed are methods of making and using homogenized formulations by providing a pre-homogenized composition comprising one or more microcapsules and then homogenizing the composition. Some specific homogenization processes described are ultrasonic and pressure-based homogenizations.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: May 15, 2018
    Assignee: DSM NUTRITIONAL PRODUCTS AG
    Inventors: Jonathan Michael Curtis, Wei Zhang, Sharon Ann Spurvey, Suzelle Rejeanne Robert
  • Patent number: 9816059
    Abstract: A capsule composition containing a capsule and a stabilizing agent. The capsule has an oil core containing an active material and a capsule wall encapsulating the oil core. The active material is a fragrance, a flavor, a malodor counteractant, or a combination thereof. The wall is formed of polyurea or polyurethane. The capsule composition has 20 ppm or greater of the stabilizing agent, which is a multi-functional amine, an amino acid, a polymer mixture, or a combination thereof. Also disclosed is a consumer product containing this capsule composition.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: November 14, 2017
    Assignee: INTERNATIONAL FLAVORS & FRAGRANCES
    Inventors: Volkert de Villeneuve, Djurre Sijbren Postma, Elizabeth Geertruida Maria Brundel, John Brahms, Li Xu, Joan G. L. Pluter, Laura French, Yabin Lei, Lewis Michael Popplewell, Xiao Huang
  • Patent number: 9814672
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 14, 2017
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Patent number: 9714311
    Abstract: A hollow polymer particle includes a structure body that contains a structure including (1) a core polymer formed by copolymerizing a monomer mixture (a) consisting of 20 to 60% by weight of an acid group-containing monomer and 80 to 40% by weight of another monomer that is copolymerizable with the acid group-containing monomer and (2) a shell polymer formed by copolymerizing a monomer mixture (b) consisting of 0 to 15% by weight of an acid group-containing monomer and 100 to 85% by weight of another monomer that is copolymerizable with the acid group-containing monomer so that the shell polymer substantially surrounding the core polymer. The structure body has at least one void formed by neutralization of at least one portion of an acid group contained in the core polymer. The hollow polymer particle is obtained by adding a preservative during a time period after formation of the core polymer and before formation of the shell polymer.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: July 25, 2017
    Assignee: ZEON CORPORATION
    Inventor: Atsushi Yamaguchi
  • Patent number: 9655832
    Abstract: The present invention refers to a cosmetic composition of the oil-in-glycol type comprising (a) at least one sucrose non-ionic surfactant or derivatives thereof, (b) at least one fatty alcohol, (c) at least one glycol and (d) at least one ingredient selected from aminoacid and/or peptide, as well as associated uses, products and methods. The composition of the invention is capable of restoring the cutaneous barrier, reorganizing the lipidic layer of the stratum corneum in orthorhombic, conceding hydration, renewal and cellular energization in the long run. In a particular embodiment, said composition can be used simultaneously as an emulsifying system for preparing cosmetic products, for example, in the preparation of creams, lotions, etc.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: May 23, 2017
    Assignee: ISP INVESTMENTS LLC
    Inventors: Alexandra Bazito, Maria Regina Bartuccio Raponi, Nelson Luis Perassinoto, Liliana Calore Brenner
  • Patent number: 9655360
    Abstract: There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: May 23, 2017
    Assignee: Eden Research PLC
    Inventors: Lanny Franklin, Gary Ostroff, Elizabeth Cloud, Lanna Franklin Rudeseal
  • Patent number: 9554996
    Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: January 31, 2017
    Assignee: NANOTHERAPEUTICS, INC.
    Inventor: James David Talton
  • Patent number: 9555009
    Abstract: This invention reports ciprofloxacin (CIP)-encapsulated polymeric nanoparticles and its antibacterial potential with a variety of gram positive and gram negative pathogenic bacteria. CIP-encapsulated nanoparticles of diethylaminoethyl cellulose (DEA-EC) are prepared by the multiple emulsion solvent evaporation method. CIP-encapsulated nanoparticles showed superior effectiveness to inhibit the growth of bacteria in-vitro.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 31, 2017
    Inventors: Muhammad Akhyar Farrukh, Muhammad Rehan Gul, Muhammad Khaleeq-ur- Rahman
  • Patent number: 9527969
    Abstract: The invention provides non-spherical resin particles with a novel shape capable of improving light diffusion, adhesion, oil absorption, and other properties, as well as a manufacturing method and use of the particles. Each non-spherical resin particle includes a concave portion and a convex portion formed in the concave portion, wherein the convex portion has a quasi-spherical surface. The method of manufacturing non-spherical resin particles involves a step of polymerizing 100 parts by weight of a first monomer mixture containing 77 to 99.99 parts by weight of a branched alkyl methacrylate, 0.01 to 3 parts by weight of a polyfunctional monomer, and 0 to 20 parts by weight of a monofunctional (meth)acrylate which is not a branched alkyl methacrylate, in the presence of 0.1 to 0.9 parts by weight of a chain transfer agent and 0 to 100 parts by weight of a (meth)acrylate polymer, to obtain resin particles.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: December 27, 2016
    Assignee: Sekisui Plastics Co., Ltd.
    Inventors: Masaaki Nakamura, Ryosuke Harada
  • Patent number: 9499769
    Abstract: The present invention relates to a process for producing microcapsules with a polyurea wall, as well as to the microcapsules themselves and consumer products comprising these microcapsules. The process of the invention uses 3,5-diamino-1,2,4-triazole as a specific polyamine for forming the wall with the polyisocyanate.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: November 22, 2016
    Assignee: Firmenich SA
    Inventors: Claudie Bellouard-Drevet, Damien Berthier, Marlene Jacquemond, Nicolas Pichon, Sonia Godefroy, Arnaud Struillou, Magali Lateulere, Estelle Rassat
  • Patent number: 9480681
    Abstract: Controlled release oral dosage formulations containing calcium channel blocker and processes for preparation thereof, are provided for once a day treatment. The active agent is preferably a dihydropyridine calcium channel blocker, such as nisoldipine. In one embodiment, the formulation provides controlled release of micronized nisoldipine with one or more pH independent release controlling polymers. The controlled release matrix formulation is advantageous and can be prepared by a simple, economically viable process as compared to complex core-coat prior-art versions.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: November 1, 2016
    Assignee: Emcure Pharmaceuticals Limited
    Inventors: Jitendra Mohansingh Baweja, Manoj Kumar Thottasseri, Sandip Tanaji Salunkhe, Mukund Keshav Gurjar, Samit Satish Mehta
  • Patent number: 9477132
    Abstract: An embodiment of the invention provides a method for forming microcapsules for electrophoresis display by forming microcapsules through a complex coacervation reaction between a sulfonated styrene maleic anhydride copolymer and gelatin, wherein a mass ratio of the sulfonated styrene maleic anhydride copolymer to the gelatin is 1:10˜10:1. The method of the embodiment of the invention not only can obtain microcapsules with good sealability and stability, but also can obtain microcapsules having evenly distributed particle sizes and low cost.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: October 25, 2016
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Wenwen Sun, Chuanxiang Xu
  • Patent number: 9439416
    Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: September 13, 2016
    Assignee: Eden Research PLC
    Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff
  • Patent number: 9301544
    Abstract: The present disclosure describes methods of obtaining and/or deriving proteins from plants of the Nicotiana species and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of the Nicotiana species or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 5, 2016
    Assignee: R.J. Reynolds Tobacco Company
    Inventors: John-Paul Mua, Kyle Ford, Leigh Ann Blevins Joyce, Margarette Elisa Lovette, Joshua D. Morton, Leigh Hagan, Barry Bratcher, Samuel Mark Debusk
  • Patent number: 9283154
    Abstract: A method for making a composite particulate comprised of a colorant portion and a clear thermoplastic portion and cosmetic compositions containing the composite particulate.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 15, 2016
    Assignee: ELC Management LLC
    Inventors: Isaac David Cohen, Phillip Cummins, Milan Franz Sojka, David Walter Culhane, Christina G. Fthenakis, Jennifer L. Sobel, John Dudley Dreher, Yelena Mikhaylova