Microcapsule With Fluid Core (includes Liposome) Patents (Class 428/402.2)
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Patent number: 8071132Abstract: The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.Type: GrantFiled: June 1, 2005Date of Patent: December 6, 2011Assignee: The Penn State Research FoundationInventors: James H. Adair, Sarah M. Rouse, Jun Wang, Mark Kester, Christopher Siedlecki, William B. White, Erwin Vogler, Alan Snyder, Carlo G. Pantano, Victor Ruiz-Velasco, Lawrence Sinoway
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Patent number: 8067089Abstract: The present invention teaches a cationically charged or neutral microcapsule particle comprising an oil soluble or dispersible core material and a wall material at least partially surrounding the core material, the microcapsule wall material comprising the reaction product of a first composition in the presence of a second composition comprising an emulsifier which is cationic or nonionic, the first composition comprising a reaction product of i) an oil soluble or dispersible amine with ii) a multifunctional acrylate or methacrylate monomer or oligomer, an oil soluble acid and an initiator. The cationic or nonionic emulsifier comprises a water soluble or water dispersible material and optionally a water phase initiator. The first composition initiator and the water phase initiator is an energy-activated initiator.Type: GrantFiled: March 27, 2009Date of Patent: November 29, 2011Assignee: Appleton Papers Inc.Inventor: Todd Arlin Schwantes
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Patent number: 8067355Abstract: The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, compositions for cleaning, fabric care, or coating onto various substrates, textiles or surfaces, such particles increase the efficiency of benefit agent delivery, thereby allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.Type: GrantFiled: April 8, 2009Date of Patent: November 29, 2011Assignee: Appleton Papers Inc.Inventors: Johan Smets, Peggy Dorothy Sands, Sandra Jacqueline Guinebretiere, An Pintens, Jiten Odhavji Dihora
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Publication number: 20110281113Abstract: Elastic and ultra-lightweight hollow carbon fine particles and a method for producing such hollow carbon fine particles are to be provided. In the method, fine droplets are formed from a mixed solution containing a water soluble organic substance and lithium carbonate; composite fine particles of the water soluble organic substance and the lithium carbonate are prepared by drying the fine droplets formed from the mixed solution; and the composite fine particles are decomposed at a temperature in a range of 500° C. to 900° C.Type: ApplicationFiled: December 11, 2009Publication date: November 17, 2011Inventors: Katsumi Kamegawa, Tsuyoshi Sakaki, Kinya Sakanishi, Masaya Kodama, Keiko Nishikubo, Yoshio Adachi
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Patent number: 8058068Abstract: The present invention provides compositions useful for transfecting eukaryotic cells comprising nucleic acid complexes with peptides, wherein the peptide is optionally covalently coupled to a nucleic acid-binding group, and cationic lipids or dendrimers as transfection agents. The invention also provides transfection compositions in which a peptide is covalently linked to the transfection agent (lipid, cationic lipid or dendrimer). Inclusion of peptides or modified-peptides in transfection compositions or covalent attachment of peptides to transfection agents results in enhanced transfection efficiency. Methods for the preparation of transfection compositions and methods of using these transfection compositions as intracellular delivery agents and extracellular targeting agents are also disclosed.Type: GrantFiled: July 23, 2002Date of Patent: November 15, 2011Assignee: Life Technologies CorporationInventors: Pamela Hawley-Nelson, Jianqing Lan, PoJen Shih, Joel A. Jessee, Kevin P. Schifferli, Gulilat Gebeyehu, Valentina C. Ciccarone, Krista L. Evans
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Patent number: 8048524Abstract: The present invention relates to a multilayer polymer latex comprising a seed, a rubbery core surrounding the seed, and a shell surrounding the rubbery core, in which the seed comprises a vinyl unit, a hydrophilic unit and a crosslinker unit, as well as a preparation method thereof. The present invention can provide an acrylic polymer latex and a diene polymer latex, depending on materials constituting the core and the shell. In the present invention, the seed containing a vinyl unit, a hydrophilic unit and a crosslinker unit, and the rubbery core, are used for the preparation of the polymer latex. This can increase the rubber content of the polymer latex, thus improving the impact resistance of the polymer latex, and at the same time, reduce the viscosity of the polymer latex so as to improve the long-term workability of the polymer latex upon spray drying. Thus, polymer powder prepared from the polymer latex is excellent in not only impact resistance but also flow properties.Type: GrantFiled: December 29, 2004Date of Patent: November 1, 2011Assignee: LG Chem, Ltd.Inventors: Jeong Heon Ahn, Byung Tae Yang, Chan Hong Lee
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Patent number: 8043701Abstract: The present invention provides a polymerizable organosilicon nanocapsule, which includes: a nanoscale core A, which includes: at least one particle comprising at least one oxide or mixed oxide, KA-O, of at least one metal or semimetal selected from the group including main groups 2 to 6 of the Periodic Table, transition groups 1 to 8 of the Periodic Table, lanthanides, and mixtures thereof; and an organosilicon shell B, which includes: at least one organosilicon compound having the formula (Ia): (Si?O—)xSi—R??(Ia) wherein R is a vinyl or allyl group; wherein x is a number from 0 to 20; wherein remaining free valences of Si are each independently (KA-O)—, SiO— or —Z; wherein remaining free valences of Si? are each independently (KA-O)—, SiO—, —R, or —Z; wherein the Z's are each independently hydroxyl or alkoxy radicals; and wherein each Si and Si? in the shell B have not more than one R group attached thereto.Type: GrantFiled: October 26, 2005Date of Patent: October 25, 2011Assignee: Evonik Degussa GmbHInventors: Roland Edelmann, Jaroslaw Monkiewicz
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Patent number: 8039015Abstract: Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-diethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.Type: GrantFiled: December 7, 2005Date of Patent: October 18, 2011Inventor: Tycho J. Speaker
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Patent number: 8034450Abstract: Described herein are microcapsules and emulsions prepared from low Bloom gelatin and methods of making and using thereof.Type: GrantFiled: September 15, 2005Date of Patent: October 11, 2011Assignee: Ocean Nutrition Canada LimitedInventors: Jonathan Michael Curtis, Wei Zhang, Yulai Jin, Colin James Barrow
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Publication number: 20110229529Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.Type: ApplicationFiled: March 19, 2011Publication date: September 22, 2011Applicant: Massachusetts Institute of TechnologyInventors: DARRELL J. IRVINE, Jaehyun Moon
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Patent number: 8021686Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.Type: GrantFiled: February 8, 2008Date of Patent: September 20, 2011Assignee: The University of British ColumbiaInventors: Sean C. Semple, Sandra K. Klimuk, Troy Harasym, Michael J. Hope, Steven M. Ansell, Pieter R. Cullis, Peter Scherrer, Dan Debeyer
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Patent number: 8003025Abstract: The present invention provides: a microcapsule composition for electrophoretic displays; a production process for the microcapsule composition for the electrophoretic displays; a production process for a sheet for the electrophoretic displays; and a handling method for microcapsules for the electrophoretic displays; wherein the microcapsule composition contains microcapsules and, when used for the electrophoretic displays, can make them as excellent as conventional in various performances (e.g. longtime stability of displaying, respondability of displaying, contrast, and number of times of display rewritability) and, particularly above all, can make the electrophoretic displays exhibit a very high performance as to the contrast.Type: GrantFiled: November 21, 2008Date of Patent: August 23, 2011Assignees: Seiko Epson Corporation, Nippon Shokubai Co., Ltd.Inventors: Sadao Kanbe, Hideyuki Kawai, Mitsuo Kushino, Makoto Matsumoto
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Patent number: 7993544Abstract: An apparatus for production of a clathrate hydrate with enhanced latent heat storing capability includes a gas supplier for supplying a gas to an aqueous solution containing a quaternary ammonium compound, and a cooler for cooling the aqueous solution, the apparatus producing the clathrate hydrate with enhanced latent heat storing capability including both the quaternary ammonium compound and the gas as guests by supplying the gas to the aqueous solution with the gas supplier in the stage of cooling with the cooler.Type: GrantFiled: August 25, 2010Date of Patent: August 9, 2011Assignee: JFE Engineering CorporationInventors: Keiji Tomura, Shingo Takao
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Patent number: 7985445Abstract: A novel method of forming water in oil microcapsules is disclosed. According to the invention microcapsules are obtained by steps comprising dispersing an oil soluble amine modified polyfunctional polyvinyl monomer and an oil soluble bi- or polyfunctional vinyl monomer along with a thermal or UV free radical initiator (optionally included in one or both of the oil or water phases) and an organic acid into an internal phase oil; heating or UV exposing for a time (and temperature) sufficient to oligomerize the amine modified polyfunctional polyvinyl monomer and oil soluble bi- or polyfunctional vinyl monomer forming a pre-polymer. Thereafter the process involves adding to the oil phase oil a water phase comprising a dispersion in water of an anionic emulsifier (and optionally initiator), and adding an emulsifying agent. Emulsifying the water phase into the oil phase (W/O) is controlled through the quantity of water employed.Type: GrantFiled: August 13, 2010Date of Patent: July 26, 2011Assignee: Appleton Papers Inc.Inventors: Todd Arlin Schwantes, Peggy Dorothy Sands
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Patent number: 7972555Abstract: Methods for fabricating compressible object are described. These compressible objects may be utilized in drilling mud and with a drilling system to manage the density of the drilling mud. The method includes selecting an architecture for a compressible object; selecting a wall material for the compressible object; and fabricating the compressible object, wherein the compressible object has a shell that encloses an interior region, and has an internal pressure (i) greater than about 200 pounds per square inch at atmospheric pressure and (ii) selected for a predetermined external pressure, wherein external pressures that exceed the internal pressure reduce the volume of the compressible object.Type: GrantFiled: October 16, 2008Date of Patent: July 5, 2011Assignee: ExxonMobil Upstream Research CompanyInventors: Richard S. Polizzotti, Dennis George Peiffer, Ramesh Gupta, Norman M. Pokutylowicz, Barbara Carstensen, Michael J. Luton, Paul Matthew Spiecker
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Patent number: 7968510Abstract: The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, compositions for cleaning, fabric care, or coating onto various substrates, textiles or surfaces, such particles increase the efficiency of benefit agent delivery, thereby allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.Type: GrantFiled: November 20, 2007Date of Patent: June 28, 2011Assignee: The Procter & Gamble CompanyInventors: Johan Smets, Peggy Dorothy Sands, Sandra Jacqueline Guinebretiere, An Pintens, Jiten Odhavij Dihora
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Publication number: 20110150954Abstract: Substantially leachless, agent-encapsulating sol-gel particles, methods of preparing same and products containing same are provided.Type: ApplicationFiled: March 3, 2011Publication date: June 23, 2011Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Noa LAPIDOT, Merav BLANCA, Claudio ROTTMAN, Oleg NAIGERTSIK
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Publication number: 20110135933Abstract: A method for controlling a particle diameter and a particle diameter distribution of emulsion particles during manufacturing of an emulsion dispersion is provided. The method includes causing two or more types of liquids substantially immiscible with each other to continuously and sequentially pass through net bodies. The net bodies are disposed in a cylindrical flow passage at intervals of 5 to 200 mm, and the number of the net bodies is more than 50 and 200 or less. Each of the net bodies is equivalent to a gauze having a mesh number of 35 mesh to 4000 mesh in accordance with an ASTM standard and has a surface that intersects the direction of the flow passage. An emulsification apparatus used for the method includes a feed pump for feeding two or more types of liquids substantially immiscible with each other; and a cylindrical flow passage to which the two or more types of liquids fed by the feed pump are delivered.Type: ApplicationFiled: October 1, 2008Publication date: June 9, 2011Inventors: Toshikatsu Shoko, Shozo Hayashi, Hideko Hayashi, Yasuo Togami, Akira Takagi
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Patent number: 7947370Abstract: The invention relates to microcapsules made of a core which contains at least one rubber additive and of a shell made of a first polymer. At least one coating made of a second polymer, which differs from the first polymer, and/or of a low molecular inorganic or organic compound, is deposited on the surface of the microcapsules as sliding or wearing layer in order to reduce the static friction.Type: GrantFiled: September 4, 2003Date of Patent: May 24, 2011Assignee: Schill + Seilacher GmbHInventors: Monika Jobmann, Gerald Rafler, Jozef Sagala, Ingeborg Gross
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Publication number: 20110111208Abstract: “The present invention relates to the use of an encapsulated adhesion promoter in an effective amount in an aqueous adhesive joint, said aqueous adhesive joint being intended to bond a surface of a first substrate (S1) to a surface of a second substrate (S2), at least one of said two substrates comprising a material (TPE-PA) comprising at least one thermoplastic elastomer (TPE) and/or at least one polyamide (PA), said adhesion promoter (P) comprising at least one organic molecule having at least one isocyanate function blocked by encapsulation of said organic molecule.Type: ApplicationFiled: July 1, 2009Publication date: May 12, 2011Applicant: Arkema FranceInventors: Bruno D'Herbecourt, Rene-Paul Eustache
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Patent number: 7938897Abstract: The present invention relates to microencapsulated compositions of isothiazolone derivatives and other water insoluble biocides or antifouling agents. In particular, the present invention relates to microencapsulated 4,5 dichloro 2 n-octyl-3(2H)-isothiazolone (DCOIT), useful in marine antifouling coatings and paints.Type: GrantFiled: April 1, 2009Date of Patent: May 10, 2011Assignee: Microtek Laboratories Inc.Inventors: Ronald Lee Hart, David Russell Virgallito, Dale Ellis Work
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Patent number: 7932191Abstract: A composition comprising particles which comprise a core material within a polymeric shell, wherein the core material comprises a hydrophobic substance, in which the amount of the polymeric shell forms at least 8% of the total weight of the particles, wherein the polymeric shell comprises a copolymer formed from a monomer blend which comprises, A) 5 to 90% by weight of an ethylenically unsaturated water soluble monomer, B) 5 to 90% by weight of a multifunctional monomer, and C) 0 to 55% by weight other monomer, and wherein the amount of the polymeric shell and the proportions of. A, B and C are such that the particles exhibit a half height of at least 350° C. The invention includes a process for the manufacture of particles and the use of particles in articles, such as fabrics, and coating compositions, especially for textiles.Type: GrantFiled: April 18, 2005Date of Patent: April 26, 2011Assignee: Ciba Specialty Chemicals Water Treatments Ltd.Inventors: Howard Roger Dungworth, Rachel Weston, Rebecca Kelly
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Patent number: 7931967Abstract: The invention provides a thermally foamable microsphere having a structure with a foaming agent encapsulated in a shell formed of a polymer, wherein the shell contains an organosilicon compound, and a process for producing a thermally foamable microsphere having a structure with a foaming agent encapsulated in a shell formed of a polymer by suspension polymerization of a polymerizable mixture containing at least a foaming agent and a polymerizable monomer in an aqueous dispersion medium, wherein the polymerizable mixture is suspension polymerized in the presence of the organosilicon compound.Type: GrantFiled: June 10, 2002Date of Patent: April 26, 2011Assignee: Kureha CorporationInventors: Yasuhiro Tasaki, Genzo Asai, Yoshikatsu Satake
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Patent number: 7914714Abstract: The methods of the invention employ electrostatic atomization to form a compound droplet of at least two miscible fluids. The compound droplet comprises a core of a first fluid and a layer of a second fluid completely surrounding the core. The first fluid contains the agent to be encapsulated and the second fluid contains an encapsulating agent. The first and second liquids are miscible. The encapsulated droplets can contain a variety of materials including, but not limited to, polynucleotides such as DNA and RNA, proteins, bioactive agents or drugs, food, pesticides, herbicides, fragrances, antifoulants, dyes, oils, inks, cosmetics, catalysts, detergents, curing agents, flavors, fuels, metals, paints, photographic agents, biocides, pigments, plasticizers, propellants and the like and components thereof. The droplets can be encapsulated by a variety of materials, including, but not limited to, lipid bilayers and polymer shells.Type: GrantFiled: May 14, 2004Date of Patent: March 29, 2011Assignee: The Regents of the University of ColoradoInventors: Thomas J. Anchordoquy, Corinne Lengsfeld, Kelly Brinkley, Ryan Jones
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Patent number: 7914891Abstract: Microencapsulated delivery vehicles comprising an active agent are disclosed. In one embodiment, the microencapsulated delivery vehicles are heat delivery vehicles capable of generating heat upon activation. The microencapsulated heat delivery vehicles may be introduced into wet wipes such that, upon activation, the wet wipe solution is warmed resulting in a warm sensation on a user's skin. Any number of other active ingredients, such as cooling agents and biocides, can also be incorporated into a microencapsulated delivery vehicle.Type: GrantFiled: December 28, 2005Date of Patent: March 29, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: John David Amundson, Alan Edward Wright, Frank P. Abuto, Michael S. Brunner, Wael R. Joseph, Larry E. Brown, David Charles Musil, Michael Allen Daley, Jeffrey David Shelley, Brian Patrick Argo, David J. Drath, William A. Hendrickson, Hal Arthur LaFleur, III, Duane G. Krzysik
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Patent number: 7901772Abstract: A microcapsule which is able to stably retain a benefit agent such as a volatile substance for an extended period, and which is also suitable for encapsulating fragrances and the like. Such capsule encapsulates a mixture comprising a volatile substance, and an additive that has a higher melting point than the volatile substance and is able to undergo mutual dissolution with the volatile substance, wherein the mixture exhibits a melting point range, and a portion of, or all of, that melting point range falls within a range from ?20 to 60° C. The present invention also relates to consumer products including cleaning and/or treatment compositions comprising such microcapsules, and processes of making and using same.Type: GrantFiled: September 25, 2006Date of Patent: March 8, 2011Assignee: The Procter & Gamble CompanyInventors: Johan Smets, Radhakrishnan Janardanan Nair, An Pintens, Takuya Yasuhara, Takashi Iwasaki
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Publication number: 20110052645Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.Type: ApplicationFiled: April 25, 2008Publication date: March 3, 2011Inventor: Ivan Coulter
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Patent number: 7883774Abstract: The invention herein provides for an improved fill composition for encapsulation in casing structures adapted for projectile motion and rupture upon contact with a target surface, such as paintballs. The fill composition adapted for use in an impact-rupturable capsule of the invention comprises a water soluble dye and soy oil. The invention further provides for an improved shell composition for an impact-rupturable capsule containing the fill composition.Type: GrantFiled: March 22, 2007Date of Patent: February 8, 2011Assignee: JT Sports LLCInventor: Yancy Baggs
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Patent number: 7883648Abstract: Lipobeads (liposome-encapsulated hydrogels) combine properties of hydrogels and liposomes to create systems that are sensitive to environmental conditions and respond to changes in those conditions in a fast time scale. Lipobeads may be produced by polymerizing anchored or unanchored hydrogels within liposomes or by mixing anchored or unanchored hydrogels with liposomes. Giant lipobeads may be produced by shrinking unanchored nanogels in lipobeads and fusing the resulting lipobead aggregates, long-term aging of anchored or unanchored lipobeads, or mixing anchored or unanchored aggregated nanogels with liposomes. Poly(acrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylacrylamide-co-1-vinylimidazole) lipobeads were produced and characterized.Type: GrantFiled: November 16, 2009Date of Patent: February 8, 2011Assignee: Polytechnic Institute of New York UniversityInventors: Sergey Kazakov, Marian Kaholek, Kalle Levon
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Patent number: 7879747Abstract: An elastic laminate having fragrance releasing microcapsules embedded within a nonwoven web layer of the laminate is generally disclosed. The elastic laminate is configured to release the encapsulated fragrance upon stretching the laminate. The elastic laminate can continue to release fresh fragrance even after the first stretching force is applied, effectively extending the life of the elastic laminate. The resulting elastic laminate is useful for many applications, and is particularly useful in the construction of an absorbent article.Type: GrantFiled: March 30, 2007Date of Patent: February 1, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: John H. Conrad, Patrick Payne
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Publication number: 20110020519Abstract: An encapsulated material is formed by congealing droplets of a molten blend of oxidatively unstable material and phytosterol in a chilling gas stream to form prilled cores containing oxidatively unstable material and phytosterol, and encapsulating the prilled cores in one or more protective shell layers to form free-flowing microparticles.Type: ApplicationFiled: July 1, 2010Publication date: January 27, 2011Inventors: Robert G. Bowman, Christopher J. Rueb, John M. Finney, William A. Hendrickson, Chetan S. Rao, Nita M. Bentley, Richard M. Herreid
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Patent number: 7863345Abstract: A process for producing a microparticulate hardening catalyst, comprising the steps of jetting a liquid composition containing epoxy resin hardening catalyst (A), monomer having an ethylenically unsaturated group (B) and photopolymerization initiator (C) through a minute nozzle into a gas so as to form microparticles; and while the microparticles are floating, irradiating the same with high-energy rays to thereby effect polymerization of the monomer having an ethylenically unsaturated group (B).Type: GrantFiled: July 6, 2006Date of Patent: January 4, 2011Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hiroo Koyanagi, Makoto Uchida, Shigeru Moteki
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Patent number: 7858183Abstract: A particle with a diameter of at most about 3,000 microns has an internal pressure of at least about 1.1 atmospheres at a temperature of less than about 25° C.Type: GrantFiled: March 2, 2005Date of Patent: December 28, 2010Assignee: Boston Scientific SciMed, Inc.Inventors: Steven M. Anderson, Janel Lanphere
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Publication number: 20100297023Abstract: The present invention provides a lipid of the formula (I) R3R4N—[Y]q—(CpH2p)—X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from —NR7—, —C(?O)—NR8—, —NR9—C(?O)—, —C(?O)—, —O—, and NR10—C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula —(OCH2CH2)1-10, —NR6-(CvH2v)—C(?O)—, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —C(=0)-(CH2)0-10—CH2—C(=0)Type: ApplicationFiled: December 21, 2007Publication date: November 25, 2010Inventors: Andrew David Miller, Patrick Arbuthnot, Michael Jorgensen, Michael Keller, Nazila Kamaly, Abderrahim Aissaoui, Maya Thanou
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Publication number: 20100297446Abstract: The present disclosure relates to a microcapsule and a method of forming a microcapsule which may be used for oxygen sensitive materials. The microcapsule may comprise a shell encapsulating a core material having a surface, wherein the shell comprises a first organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges. This may then be followed by forming a first layer comprising an inorganic or organic polyelectrolyte on the microcapsule surface, where the polyelectrolyte of the first layer provides a plurality of cationic or anionic charges, opposite to the charge of the shell polyelectrolyte. This may then be followed by forming a second layer comprising a second organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges, opposite to the charge of the first layer polyelectrolyte.Type: ApplicationFiled: May 19, 2009Publication date: November 25, 2010Applicant: Southwest Research InstituteInventors: James D. OXLEY, Jenny J. FINKBINER, Darren E. BARLOW
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Patent number: 7838037Abstract: The present invention provides methods for microencapsulation of active ingredients for topical application, whereby double-layer and triple-layer microcapsules are obtained. The microcapsules protect the active ingredients, maintain their original activity throughout processing, formulation and storage, and enable controlled release of the active ingredient only upon application onto the skin.Type: GrantFiled: August 22, 2005Date of Patent: November 23, 2010Assignee: Tagra Biotechnologies Ltd.Inventors: Emma Kvitnitsky, Yury Shapiro, Olga Privalov, Irena Oleinik, Igor Polisher
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Patent number: 7829272Abstract: A method of generating pathogen detecting liposomes includes a step of providing molecular beacons with fluorescing components. The molecular beacons include either strands of RNA or DNA and the fluorescing components include an emitter and a quencher. The method further uses nanodroplet technology to encapsulate the molecular beacons within a lipid membrane. Subsequently, receptors are assembled in association with the membrane.Type: GrantFiled: May 24, 2007Date of Patent: November 9, 2010Assignee: Nanotrope Inc.Inventors: Eugene Tu, Donald E. Ackley, Anita Forster, Michael Krihak
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Patent number: 7807076Abstract: An improved process for the preparation of microcapsules consisting essentially of a wall material and a core material in condensing a melamine-formaldehyde precondensate and/or methyl ethers thereof in an aqueous dispersion of a water-insoluble core material and in the presence of an acrylic acid/acrylamide copolymer at acidic pH and at a temperature in the range of from 20° to 100° C., and hardening thereafter the melamine-formaldehyde precondensate to form the walls of the microcapsules at an elevated temperature, wherein the core material is dispersed in the precondensate/copolymer solution without initial partial condensation of the precondensate and copolymer and wherein the hydrophobe point of the precondensate and/or its methyl esters is less than 90° C., as well as microcapsules, paper and pressure-sensitive recording material comprising such microcapsules.Type: GrantFiled: October 17, 2002Date of Patent: October 5, 2010Assignee: Ciba Specialty Chemicals Corp.Inventors: Ann Hunt, Robert Montgomery O'Neil
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Patent number: 7803422Abstract: A novel method of forming water in oil microcapsules is disclosed. According to the invention microcapsules are obtained by steps comprising dispersing an oil soluble amine modified polyfunctional polyvinyl monomer and an oil soluble bi- or polyfunctional vinyl monomer along with a thermal or UV free radical initiator (optionally included in one or both of the oil or water phases) and an organic acid into an internal phase oil; heating or UV exposing for a time (and temperature) sufficient to oligomerize the amine modified polyfunctional polyvinyl monomer and oil soluble bi- or polyfunctional vinyl monomer forming a pre-polymer. Thereafter the process involves adding to the oil phase oil a water phase comprising a dispersion in water of an anionic emulsifier (and optionally initiator), and adding an emulsifying agent. Emulsifying the water phase into the oil phase (W/O) is controlled through the quantity of water employed.Type: GrantFiled: May 18, 2006Date of Patent: September 28, 2010Assignee: Appleton Papers Inc.Inventors: Todd Arlin Schwantes, Peggy Dorothy Sands
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Patent number: 7794835Abstract: A fixing solution for fixing toner to a recording medium, includes aliphatic ester held by solvent in a soluble manner, and having solubility or swelling property with respect to resin included in the toner.Type: GrantFiled: November 24, 2008Date of Patent: September 14, 2010Assignee: Ricoh Company, Ltd.Inventors: Yasuo Katano, Tsuneo Kurotori, Hiromichi Komai, Hidenori Tomono
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Patent number: 7790283Abstract: Cellulosic fibers having enhanced reversible thermal properties and applications of such cellulosic fibers are described. In one embodiment, a cellulosic fiber includes a fiber body including a cellulosic material and a set of microcapsules dispersed in the cellulosic material. The set of microcapsules contain a phase change material having a latent heat of at least 40 J/g and a transition temperature in the range of 0° C. to 100° C., and the phase change material provides thermal regulation based on at least one of absorption and release of the latent heat at the transition temperature. The cellulosic fiber can be formed via a solution spinning process, and can be used in various products where thermal regulating properties are desired.Type: GrantFiled: June 29, 2007Date of Patent: September 7, 2010Assignee: Outlast Technologies, Inc.Inventors: Mark Hartmann, James Brice Worley, Matthew North
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Patent number: 7790225Abstract: Coatings and methods are provided. An embodiment of the coating includes microcapsules that contain at least one of a corrosion inhibitor, a film-forming compound, and an indicator. The microcapsules are dispersed in a coating vehicle. A shell of each microcapsule breaks down in the presence of an alkaline condition, resulting from corrosion.Type: GrantFiled: September 19, 2005Date of Patent: September 7, 2010Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Luz M. Calle, Wenyan Li
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Patent number: 7780983Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.Type: GrantFiled: October 31, 2006Date of Patent: August 24, 2010Assignee: Novosom AGInventors: Steffen Panzner, Stefan Fankhänel, Frank Essler, Cornelia Panzner, Gerold Endert
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Publication number: 20100209524Abstract: Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.Type: ApplicationFiled: April 27, 2010Publication date: August 19, 2010Applicant: OCEAN NUTRITION CANADA LTD.Inventor: Nianxi Yan
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Patent number: 7776240Abstract: Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution.Type: GrantFiled: December 4, 2003Date of Patent: August 17, 2010Assignee: Cornell Research Foundation, Inc.Inventors: Chih-Chang Chu, Xian-Zheng Zhang, Da-Qing Wu
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Patent number: 7776939Abstract: The polymeric nanoparticles including olfactive components have a glass temperature of >50° C. They are obtainable by continuously adding a monomer component and an olfactive component to an aqueous solution. The aqueous solution comprises a first initiator and an emulsifier. The added components are distributed in the aqueous solution to obtain reaction mixture while the polymerization of the monomer component is started at the first temperature. The liquid monomer component and the olfactive component are added continuously while a second initiator is added dropwise to the reaction mixture and the first temperature is maintained. After terminating the addition of liquid monomer component and the olfactive component the temperature of the reaction mixture is increased to a second temperature and a third initiator is added dropwise.Type: GrantFiled: March 12, 2007Date of Patent: August 17, 2010Assignee: Givauden SAInventors: Christian Quellet, Jutta Hotz, Marc Balmer
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Patent number: 7776443Abstract: The invention herein provides for an improved dye composition for encapsulation in casing structures adapted for projectile motion and rupture upon contact with a target surface, such as paint balls. The dye composition adapted for use in an impact-rupturable capsule of the invention comprises a water soluble dye and a lipophilic carrier having an oil and a nonionic surfactant, said surfactant comprising greater than 97% Poly[oxy-1,2-ethanediyl], alpha-[4-nonylphenyl]-omega-hydroxy-, branched and less than 3% polyethylene glycol and less than 2% dinonylphenyl polyoxyethylene by weight. The invention further provides for an impact-rupturable capsule containing the dye composition.Type: GrantFiled: August 9, 2006Date of Patent: August 17, 2010Assignee: Brass Eagle, LLCInventor: Yancy Baggs
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Patent number: 7772287Abstract: A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.Type: GrantFiled: November 28, 2005Date of Patent: August 10, 2010Assignee: Japan Science & Technology AgencyInventors: Toshiro Higuchi, Toru Torii, Takashi Nishisako, Tomohiro Taniguchi
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Publication number: 20100189777Abstract: The invention is directed to vesicles comprising at least one transmembrane triggered transport system for controlled transmembrane efflux and/or influx.Type: ApplicationFiled: July 7, 2008Publication date: July 29, 2010Applicant: BASF SEInventors: Ulrich Schwaneberg, Ozana Onaca, Prasenjit Sarkar, Bernhard Hauer, Thomas Friedrich
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Publication number: 20100165447Abstract: There is disclosed a process for producing microcapsules for electrophoretic display devices, including classifying microcapsules for electrophoretic display devices from a dispersion containing microcapsules in an aqueous medium, using a specific particle classification apparatus of the particle settling type. The resultant microcapsules for electrophoretic display devices are used, as their applications, for sheets for electrophoretic display devices, electrophoretic display devices, and electronic equipments.Type: ApplicationFiled: December 22, 2009Publication date: July 1, 2010Inventors: Harunobu KOMATSU, Shinji TAKASAKI, Hironobu HASHIMOTO