Including Position Control Patents (Class 435/286.2)
  • Patent number: 8202486
    Abstract: The invention provides a device, system, and method for isolating one or more sample components of a sample material following separation of the sample material into a plurality of sample components. The device includes first and second pinching channels, a separation channel extending between the first and second pinching channels, a collection leg that includes a collection well, and a waste leg, all of which are in fluid communication with a switching region. In the method, a sample material is separated into a plurality of separated components in the device. and one or more of the separated components are isolated in the collection well. The separated components are constrained and elongated in the switching region by first and second buffer streams.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: June 19, 2012
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Josh Molho, Hui Xu, Jorge J. Zaninovich
  • Publication number: 20120149093
    Abstract: A device which collects specimen fluids or performs chemical or biological assays of the specimen fluid is provided with a specimen fluid receiver and a fluid actuated expandable trigger coupled to receive specimen fluid from the specimen fluid receiver such that a predetermined delay occurs before the trigger expands sufficiently to move another component of the device, and the specimen fluid interacts with a substance during the delay. The trigger is made of a material which expands substantially upon absorbing specimen fluid, and it is mounted and positioned so as to contact and move the other component of the device upon expanding through the absorption of specimen fluid. The other component may contain a surface coupled to receive specimen fluid from the specimen fluid receiver and the surface has an area which contains a substance which interacts with the specimen fluid.
    Type: Application
    Filed: November 2, 2011
    Publication date: June 14, 2012
    Inventors: Jason Gould, Martin Gould, Susan Gould
  • Patent number: 8198075
    Abstract: A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: June 12, 2012
    Assignee: UT-Battelle, LLC
    Inventors: Elias Greenbaum, Miguel Rodriguez, Jr., Jie Jayne Wu, Hairong Qi
  • Patent number: 8192983
    Abstract: An incubator including a temperature-controlled room adjusted to a predetermined environment condition for culturing a sample of an incubation container at inside of the temperature-controlled room, the incubator including a shifting mechanism for moving a position of the incubation container at inside of the temperature-controlled room by a motor, a temperature adjusting section for adjusting a temperature at inside of the temperature-controlled room, an operating information generating section for generating operating information with regard to a position of operating and a time period of operating the motor prior to operating the motor, an estimated variation outputting section for outputting an estimation variation of a temperature state by operating the motor based on the operating information, and a controlling section for controlling the temperature adjusting section to cancel a temperature change of an amount of the estimated variation in synchronism with operating the motor.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: June 5, 2012
    Assignee: Nikon Corporation
    Inventors: Yasujiro Kiyota, Takayuki Uozumi, Nobuhiko Maiya, Hirofumi Shiono
  • Patent number: 8163238
    Abstract: An automated micro-well plate handling device for removing a micro-well plate from within a vertically stacked plurality of micro-well plates and transferring the removable micro-well plate to a receiving area. A vertical storage device for storing the vertically stacked plurality of micro-well plates creates a vertical clearance space between the vertically stacked micro-well plates. A shovel slides into the vertical clearance space underneath the micro-well plate that is being removed. The shovel then removes the micro-well plate from the vertical storage device and places the micro-well plate at a transfer station. A gripper then grabs the micro-well plate from the transfer station and transfers the micro-well plate to a receiving area. In a preferred embodiment, the automated micro-well plate handling device is controlled via a computer network.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: April 24, 2012
    Assignee: Let 's Go Robotics, Inc.
    Inventors: Brian L. Ganz, Nicholas P. Pratte, Anthony L. Moore, Chinapong Songchan
  • Patent number: 8114348
    Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: February 14, 2012
    Assignee: Corning Incorporated
    Inventors: Stephen J. Caracci, Volker H. O. Eckelt, Anthony G. Frutos, Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
  • Patent number: 8105633
    Abstract: Apparatus and method for the extraction of material from glands of arthropods. The apparatus includes a container in which at least part of the glands are placed and a buffer solution at least partially immersing the glands. Gland material is collected in the material collection area of the container, e.g., by release of the material from the glands into the buffer solution and sedimentation of the material at the bottom of the container. The method involves removing from a body of the arthropod the gland containing at least partially the material, making an opening in an epithelium of the gland, and placing the gland in the container at least partially immersed in a buffer solution, so that the material exits the glands and sediments in the material collection area of the container.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: January 31, 2012
    Assignee: Spintec Engineering GmbH
    Inventors: Michael Rheinnecker, Stefan Kohlhaas, Rolf Zimmat
  • Patent number: 8097211
    Abstract: An analyzer comprising: a first specimen holder configured to hold a plurality of first specimen containers; a conveying assembly for conveying the first specimen containers held in the first specimen holder; a second specimen holder arranged at a position higher than an upper end of the first specimen containers held in the first specimen holder; a holder moving assembly for moving the second specimen holder so as to pass the upper side of at least one of the first specimen containers held in the first specimen holder; a container transferring assembly for transferring at least one of the first specimen containers from the first specimen holder to the second specimen holder; and a controller for controlling the holder moving assembly and the container transferring assembly, is disclosed.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: January 17, 2012
    Assignee: Sysmex Corporation
    Inventors: Yuichi Hamada, Masaharu Shibata, Daigo Fukuma
  • Patent number: 8092743
    Abstract: A device for handling of laboratory samples includes at least one gripper movable from above over a sample. The gripper includes multiple fingers arranged around an axis, an elastic finger mount, and an actuator mechanism structured and arranged to move the fingers to selectively grip or release the sample. The multiple fingers are elastically held by the elastic finger mount in a radially displaceable manner.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: January 10, 2012
    Assignee: Liconic AG
    Inventor: Cosmas G. Malin
  • Publication number: 20120003679
    Abstract: A sensor module (38, 40, 42) for a tissue processor (20) has a thermal sensor (66) for measuring a temperature of a container (30, 32, 34) of the tissue processor (20), and further has a position sensor for detecting a working position of the container (30, 32, 34).
    Type: Application
    Filed: May 10, 2011
    Publication date: January 5, 2012
    Applicant: Leica Biosystems Nussloch GmbH
    Inventor: Claus Haberkorn
  • Publication number: 20110256523
    Abstract: The present invention relates to a flow cytometer (10) for in vitro assaying of human or animal whole blood and to an investigation method using the flow cytometer. Enhanced detection properties are achieved by it relative to the prior art cytometers of the same kind. Here, automated beam positioning is also solved. To these ends, collection of light scattered by the cellular components of human or animal whole blood and its transmission to suitable optical sensing elements take place by a coupling member with a particular end construction, in particular through one or more optical fiber bundles. Preparation of a blood sample for the assay, that is, mixing up said human or animal whole blood with appropriate reagents is performed by a hydro-pneumatical unit (12) of a particular design. Moreover, the actual assaying takes place in a flow cell (22) of a particular construction, which assists to improve the signal-to-noise ratio of the present flow cytometer.
    Type: Application
    Filed: October 13, 2009
    Publication date: October 20, 2011
    Applicant: Diatron MI Zrt.
    Inventors: Bálint Tibor Mendele, Attila Zsolt Tremmel, Péter Tóth-Miklós, Péter Kovács, László Lehel Laczó, Miklós Zsolt Svarcz
  • Patent number: 8030058
    Abstract: Advanced islet separation technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic islets in a tissue suspension in physiologic process solution, utilizing microprocessor control and/or microprocessor computer control and software programming (code) to interface and control the process temperature, fluid flow rate, pH, dissolved oxygen concentration, endotoxin concentration, dissolved nitric oxide concentration, nitric oxide synthase activity, proteolytic enzyme activity, and/or pressure of the islet containing physiologic process solution, the extent of islet separation, including real-time data acquisition and recording of process variables.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: October 4, 2011
    Inventors: Daniel J. Benedict, Lorna S. Mosse
  • Publication number: 20110189720
    Abstract: An automated biological sample collection system and method are disclosed. The system comprises an incubator, an applicator and a sampler. The incubator is configured to control the environment of a plurality of eggs, the applicator is configured to deliver exogenous material to the plurality of eggs and at least one sampler is configured to collect samples from the plurality of eggs, invasively or non-invasively.
    Type: Application
    Filed: January 30, 2011
    Publication date: August 4, 2011
    Inventors: RON GOLDSTEIN, JONATHAN GOLDSTEIN, ROBERT GOLDSTEIN
  • Publication number: 20110165609
    Abstract: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
    Type: Application
    Filed: June 27, 2008
    Publication date: July 7, 2011
    Inventors: Niels B. Ramsing, Jorgen Berntsen, Jen K. Gunmark, Holger Soe Plougsgaard
  • Publication number: 20110143427
    Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
    Type: Application
    Filed: December 16, 2009
    Publication date: June 16, 2011
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
  • Publication number: 20110129909
    Abstract: A liquid sample analysis device includes a holder part 11 holding a test piece 1, an optical system 20 that optically detects a reaction state of a liquid sample and a reagent, and a support member 30 that integrally supports the holder part 11 and the optical system 20. The orientation of the test piece 1 is changed with respect to the direction of gravitational force by rotating the support member 30.
    Type: Application
    Filed: July 28, 2009
    Publication date: June 2, 2011
    Applicant: PANASONIC CORPORATION
    Inventors: Kenji Murakami, Masahiro Aga, Hideyuki Kurokawa, Takahiko Tanida, Ryosuke Yamada
  • Patent number: 7936939
    Abstract: A microinjection apparatus, which injects an object into a cell with a needle, acquires a first image that is an image of the cell at a first focal position and a second image that is an image of the cell at a second focal position, and decides a state of the cell based on a difference image obtained from the first image and the second image. Execution of such sequence of processing makes it possible to measure a state of a cell without involving human work and confirm the state of the cell in performing a microinjection, without a necessity of experienced skill, efficiently, and simply.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: May 3, 2011
    Assignee: Fujitsu Limited
    Inventors: Moritoshi Ando, Sachihiro Youoku
  • Patent number: 7934622
    Abstract: An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation instruments in a manner to avoid DCM dust inhalation by persons in the surrounding area and contamination of equipment and surfaces in the surrounding area. The system can further comprise a carousel arrangement that permits dispensing of DCM powder from multiple containers at multiple volumes and rates. In addition, the containers have a particular configuration for use with the system and method, such as the carousel arrangement, to avoid errors, promote repeatability and eliminate dusting. The containers can also include a device, such as an auger, to facilitated measured dispensing of the DCM powder automatically or manually into a flask, automated media sterilizers or other instruments.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: May 3, 2011
    Assignee: Mediatek, LLC
    Inventors: Arthur G. House, Kevin P. Klink, William J. Richman
  • Patent number: 7923242
    Abstract: The objective of the present invention is to provide a simple microorganism detection apparatus that reduces detection time and that provides improved detection sensitivity, especially for gram-negative bacteria. The microorganism detection apparatus of the present invention includes: a detection target introduction portion, into which a sample and reagents are to be introduced; a detector, for detecting the color tone of the reagent introduced into the detection target introduction portion; a sample holder, for holding the sample to be introduced into the detection target introduction portion; a culture solution holder, for holding a culture solution used for microorganism culturing; and reagent holders, for holding the reagents to be introduced into the detection target introduction portion, wherein the presence/absence of microorganisms in the sample is determined based on the detected color tone.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: April 12, 2011
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Eiji Kono, Hironobu Sekine, Yasuhiko Yokoi, Akihumi Iwama
  • Patent number: 7919305
    Abstract: A main object of the invention is to provide a new method for producing a cell culture substrate used to cause cells to adhere in a highly precise form onto a base material and then culture the cells.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: April 5, 2011
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Hideyuki Miyake, Hideshi Hattori, Yoichi Takahashi
  • Patent number: 7892490
    Abstract: Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: February 22, 2011
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kwang-wook Oh, Yu-jin Seo
  • Patent number: 7883887
    Abstract: To present an automatic cell cultivation apparatus capable of sterilizing completely including a cold storage unit and a normal temperature storage unit, without causing cross contamination, in used of cell cultivation of plural subjects.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: February 8, 2011
    Assignees: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Mutsumi Takagi, Katsumi Nakashima, Toshihisa Doi, Takamasa Ogata
  • Publication number: 20110014685
    Abstract: A cell processing apparatus 29 of the present invention includes a storage container 57 that can contain liquid L including a biological sample; a filter 60 that prevents a first cell C1 in the biological sample from passing therethrough and that allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass therethrough; and a filtration cylinder 58 for separating, in the storage container 57 and via the filter 60, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell discriminated by the filter from the other cells can be easily collected.
    Type: Application
    Filed: September 28, 2010
    Publication date: January 20, 2011
    Inventors: Masakazu Fukuda, Hironori Kobayashi, Junyi Ding, Ryuichiro Ebi, Koki Tajima
  • Patent number: 7871810
    Abstract: Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive detector (PSD). The PSD-measured positional deviation can be transformed and used in a control loop to correct for positional variations of the array. The calibration beam and PSD may also be used to detect the array or feature boundaries, thereby allowing lateral centering or positioning of the array relative to the signal acquisition device.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: January 18, 2011
    Assignee: Life Technologies Corporation
    Inventors: Scott R. Warren, Louis B. Hoff, Mark F. Oldham
  • Patent number: 7855067
    Abstract: To provide a microinjection equipment capable of fitting a micro needle to a manipulator etc. manipulating the micro needle in short time on the occasion of an injection operation. Included are a micro needle transporting device 12 detachably grasping a micro needle 10 filled with an introduction substance and disposed in a predetermined standby position and transporting the micro needle 10 to a predetermined ready-for-introducing position, a manipulator 14 grasping in the attachable/detachable manner the micro needle 10 disposed in the predetermined ready-for-introducing position and inserting and removing the tip of the micro needle 10 into and from an introduction target micro body 13, and an introduction substance discharging device 15 discharging the introduction substance in the micro needle 10 by applying a predetermined pressure to an interior of the micro needle 10 grasped by the manipulator 14.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: December 21, 2010
    Assignee: Fujitsu Limited
    Inventors: Jun Sasaki, Akihiko Yabuki, Shusaku Nishiyama, Ikushi Takasaki
  • Patent number: 7854959
    Abstract: A simple and reproducible preparative method for the fabrication of surface-chemical gradients is described herein. Surface-chemical gradient films are prepared by using a liquid front in relative motion to the substrate (e.g. immersion by a linear-motion drive or the use of a spreading droplet) to gradually expose substrate samples to very dilute solutions of adsorbates. As demonstrated by XPS, the self-assembled monolayer gradients produced in this way display a high packing density. This method can be used in the preparation of other gradients of various chemical or biochemical functionalities in one or two dimensions. Such gradients can be used in a wide variety of applications in such diverse areas as cell motility studies, nanotribology research, and high-throughput screening.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: December 21, 2010
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventors: Nicholas D. Spencer, Sara Maria Morgenthaler, Seunghwan Lee
  • Publication number: 20100291664
    Abstract: Laboratory apparatus comprises at least one cabinet; at least one incubator; at least one transfer hatch; and means for circulating air within the apparatus, wherein the at least one cabinet is connected to an incubator and a transfer hatch; wherein the at least one incubator comprises at least two discrete compartments each accessible by independent openings; and wherein the apparatus is substantially sealed against exchange of air between the cabinet and the external environment.
    Type: Application
    Filed: October 27, 2006
    Publication date: November 18, 2010
    Inventors: Mary Herbert, Stephen Harbottle, Jeannette Fenwick, James Walker
  • Patent number: 7824927
    Abstract: Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: November 2, 2010
    Assignee: George Mason Intellectual Properties, Inc.
    Inventors: Victor Morozov, Charles L. Bailey, Melissa R. Evanskey
  • Patent number: 7820103
    Abstract: A diagnostic device comprising a sample inlet and a processing chamber having a window portion and a flat carrier having front surface, a back surface and one or more side surfaces, said front surface facing said processing chamber, said front surface having an active surface containing a diagnostic reagent immobilized to said active front surface and an extended front surface, wherein said window portion further contains a rim portion facing said extended front surface sealing said chamber versus said carrier through said extended front surface.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: October 26, 2010
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Haack Carsten
  • Publication number: 20100267142
    Abstract: A scalable packed-bed cell culture device includes a matrix vessel, a mixing vessel, a communicating means, a driving means and a controlling means. The matrix vessel includes porous matrixes packed therein. The mixing vessel includes a mixing means configured for mixing a culture medium. The communicating means is connected between the matrix vessel and the mixing vessel. The driving means is configured for driving the culture medium to flow between the matrix vessel and the mixing vessel. The controlling means configured for controlling the culture medium to submerge the porous matrixes at high level, and to emerge the porous matrixes at low level. An inoculation method and a culture method for scalable packed-bed cell culture device is also herein provided for eliminating the limitation of aeration or oxygenation during culture, alleviating the gradient effect, eliminating the channeling effect in conventional packed-bed bioreactors.
    Type: Application
    Filed: April 16, 2010
    Publication date: October 21, 2010
    Inventors: Gary Wang, King-Ming Chang, Lewis Ho
  • Patent number: 7816128
    Abstract: An automatic cell cultivation apparatus is provided which is capable of conveying the culture container, exchanging the culture medium, and operating other jobs promptly by a robot. The automatic cell cultivation apparatus has a cultivation apparatus main body for cultivating cells in a culture container, and the cultivation apparatus main body is equipped with one or more incubator accommodating the culture container, a chemical suction machine for sucking chemicals in the culture container, and a multijoint robot for conveying the culture container, the multijoint robot having functions of conveying the culture container, detaching and attaching the lid of the culture container, and inclining the container when sucking chemicals in the culture container, so that cell cultivation operations can be promptly carried out by only one robot.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: October 19, 2010
    Assignee: Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Katsumi Nakashima, Toshihisa Doi, Yohichi Nakamura
  • Publication number: 20100240118
    Abstract: A lid removable device includes a first transferring mechanism transferring a culture vessel in a horizontal direction, a second transferring mechanism raising or lowering the culture vessel, a lid removable plate having an insertion region into which a vessel body of the culture vessel is inserted and a lid placing part on which a lid of the culture vessel is placed, and a transporting control unit controlling the first transferring mechanism so that the vessel body is inserted into the insertion region when the lid is removed from the culture vessel and controlling the second transferring mechanism so that the vessel body is separated from the lid, and controlling the first transferring mechanism so that the vessel body is positioned below the insertion region when the lid is attached to the culture vessel and controlling the second transferring mechanism so that the vessel body is moved toward the lid.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 23, 2010
    Applicant: NIKON CORPORATION
    Inventor: Ryuji KOSHIBA
  • Patent number: 7785867
    Abstract: The invention provides a culture apparatus or a reserving stock room which receives a lot of culture vessels without vibration. The culture apparatus or the reserving stock room is provided with storage shelves (12a, 12b, . . . ) for culture vessels arranged in a circular arc shape or an annular shape, and a carrying means (15) for taking in and out the culture vessels to an inner side of the circular arc shaped arrangement or the annular shaped arrangement from the storage shelves (12a, 12b, . . . ). Further, the culture apparatus or the reserving stock room is provided with storage shelves (12a, 12b, . . .
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: August 31, 2010
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Yuichi Tamaoki, Takashi Arai, Tadahisa Saga, Hiroki Busujima
  • Publication number: 20100210007
    Abstract: Disclosed is an automatic analyzer that analyzes a component of a target layer of a test sample separated into a plurality of layers by transferring the component from an installed container, comprising: a dispensing probe that descends into the target layer and suctions the component; a detecting unit that detects the height of the layer surface of the target layer of the test sample; a calculating unit that calculates the depth from the layer surface of the target layer at which the total content of the component of the target layer reaches a target amount; and a controller that causes the dispensing probe to descend to the depth calculated by the calculating unit and suction the component.
    Type: Application
    Filed: February 12, 2010
    Publication date: August 19, 2010
    Applicants: Kabushiki Kaisha Toshiba, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Kanako IWAMURA, Shoichi Kanayama, Nobuyasu Kobayashi
  • Publication number: 20100178661
    Abstract: Disclosed is an automatic tissue microarray apparatus that includes: a sample module being drivable and providing a space for mounting at least one donor block and at least one recipient block; an extract module being drivable in at least two directions and having at least one punching tip for punching a tissue from the at least one donor block and arraying the punched tissue in the at least one recipient block; and a controller for controlling the driving operations of the sample module and the extract module and, in response to an externally applied command, the punching and arraying operations of the extract module. The present invention securely provides convenience in use with improved work efficiency and contributes to precision of punching and arraying operations.
    Type: Application
    Filed: October 15, 2007
    Publication date: July 15, 2010
    Applicant: UNITMA CO., LTD.
    Inventors: Young Do Lee, Hyeong Jae Jeong
  • Patent number: 7745204
    Abstract: An automated biological sample aliquoting processing system is disclosed for handling biological samples. The system reads and records a sample identification number, cuts a biological sample, and places a portion of the biological sample into a specific location in a multi-well plate. The system ensures sample integrity and also greatly reduces the man hours currently required to process biological samples. The system, which automates sample cutting and aliquoting, reduces the time and cost of operation, while eliminating manual steps in a laboratory process.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: June 29, 2010
    Assignee: Georgia Tech Research Corporation
    Inventors: Cyrus K. Aidun, Amanda C. Sozer
  • Patent number: 7727206
    Abstract: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: June 1, 2010
    Inventor: Geoffrey H. Gorres
  • Publication number: 20100075296
    Abstract: A thermal cycling system and method are provided herein, The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed; c) mechanically-operable means for altering the relative position of the heat source and the reaction vessel so that reaction vessel first achieves and maintains a desired first temperature in the reaction vessel for starting the carrying out of the biological reaction, and then for altering the relative position of the heat source and the reaction vessel so that reaction vessel then achieves and maintains a second temperate for continuing the carrying out of the biological reaction on the biological material, and d) temperature-sensing means operatively associated with the reaction vessel for controlling the altering of the relative position of the heat source and the reaction vessel so that the
    Type: Application
    Filed: July 29, 2009
    Publication date: March 25, 2010
    Applicant: Spartan Bioscience inc.
    Inventors: Martin Cloake, Chris Harder, Alan Shayanpour, Michael Perreault, Paul Lem
  • Patent number: 7651850
    Abstract: A system and method for recognition of images may include the use of alignment markers. The image recognized may be a pattern from an array, a character, a number, a shape, and/or irregular shapes. The pattern may be formed by elements in an array such as an identification marking and/or a sensor array. More particularly, the system and method relate to discriminating between images by accounting for the orientation of the image. The size and/or location of alignment markers may provide information about the orientation of an image. Information about the orientation of an image may reduce false recognitions. The system and method of image recognition may be used with identification markings, biosensors, micro-fluidic arrays, and/or optical character recognition systems.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: January 26, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jason E. Meiring, Timothy B. Michaelson, C. Grant Willson
  • Publication number: 20100009336
    Abstract: A method and system for testing fluids from a patient is provided. In one embodiment, a portable device is configured with one or more testing modules adapted perform one or more tests on a fluid sample in order to determine if a patient has bacterial vaginosis. A timer module coupled to a sample transport is configured to move a vaginal fluid sample between one or more testing modules at various stages along a predetermined testing path. In an embodiment, the timer module is configured to move the vaginal fluid sample between the testing modules along a circular testing path. The vaginal fluid sample may be processed in sequential order over predetermined time periods with respect to the processing performed by the testing module in order to detect the presence of, or lack of, Lactobacilli in the patient's vaginal flora to determine whether or not the patient has bacterial vaginosis.
    Type: Application
    Filed: July 7, 2009
    Publication date: January 14, 2010
    Inventor: Shannon E. Sullivan
  • Publication number: 20090325274
    Abstract: An analyzer comprising: a first specimen holder configured to hold a plurality of first specimen containers; a conveying assembly for conveying the first specimen containers held in the first specimen holder; a second specimen holder arranged at a position higher than an upper end of the first specimen containers held in the first specimen holder; a holder moving assembly for moving the second specimen holder so as to pass the upper side of at least one of the first specimen containers held in the first specimen holder; a container transferring assembly for transferring at least one of the first specimen containers from the first specimen holder to the second specimen holder; and a controller for controlling the holder moving assembly and the container transferring assembly, is disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: December 31, 2009
    Inventors: Yuichi Hamada, Masaharu Shibata, Daigo Fukuma
  • Patent number: 7632675
    Abstract: This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: December 15, 2009
    Assignee: BioProcessors Corp.
    Inventors: Andrey J. Zarur, Seth T. Rodgers, Todd A. Basque, Ian K. MacGregor, Timothy J. Johnson
  • Publication number: 20090305337
    Abstract: Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.
    Type: Application
    Filed: June 9, 2008
    Publication date: December 10, 2009
    Inventors: Shazi Iqbal, Steven M. Montgomery, Ronald Chang, Gregory Mote, Douglas B. Dority, Jeffrey S. Ross
  • Publication number: 20090305379
    Abstract: A manure mixture within an anaerobic digestion tank stratifies to form a liquid effluent layer and a sludge layer. Liquid effluent from the liquid effluent layer is withdrawn from the tank through a height adjustable valve. The height adjustable valve is adapted to automatically adjust the position of its intake end within the liquid effluent layer in response to the level of the sludge layer detected by a sludge meter located within the tank. Liquid effluent withdrawn from the tank is passed through a heat exchange system including at least one heat exchanger. Heat from the heat exchanger is transferred to the liquid effluent to produce heated liquid effluent. The heated liquid effluent is reintroduced back into the digestion tank such that the temperature of the manure mixture within the tank is maintained within a suitable temperature range for anaerobic digestion of the manure mixture.
    Type: Application
    Filed: June 6, 2008
    Publication date: December 10, 2009
    Inventors: Matthew W. Johnson, Dennis J. Johnson
  • Patent number: 7629173
    Abstract: An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: December 8, 2009
    Assignee: Corning Incorporated
    Inventors: Jacques Gollier, Garrett A. Piech, Michael B. Webb
  • Patent number: 7618809
    Abstract: A microarrayer apparatus for constructing arrays of biological material from donor cores obtained from at least one donor block and placing the donor cores in an embedding medium carried by at least one recipient block. The apparatus includes a donor punch, a recipient punch, and a stylus mounted for independent coaxial movement along a common punch axis. The recipient punch cooperates with the stylus when ejecting a donor core from the donor punch to minimize deformation of the donor core.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: November 17, 2009
    Inventor: Ronald A. Gebing
  • Publication number: 20090269834
    Abstract: The micro refinery first detects the weight of the sugar added to the fermentation tank and then calculates the water needed for fermentation. The feed stock is then inserted into the fermentation tank and the system adds the corresponding volume of water. The control system monitors the weight of the batch and maintains the temperature within a fermentation temperature range so the batch is converted into ethanol. In another mode of operation, discarded alcoholic beverages can be placed in the fermentation tank and processed by the micro refinery to extract the ethanol. The fermented liquid is heated and the ethanol vapors travel through a distillation tube to a membrane separation unit that separates water from the ethanol. The distillation tube has an alignment system that orients the distillation tube vertically automatically. The ethanol from the membrane separation unit is then stored in a storage container prior to use in a vehicle.
    Type: Application
    Filed: April 25, 2008
    Publication date: October 29, 2009
    Inventor: Thomas J. Quinn
  • Publication number: 20090269835
    Abstract: A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.
    Type: Application
    Filed: February 13, 2009
    Publication date: October 29, 2009
    Applicant: BIO-RAD LABORATORIES, INC. a corporation of the state of Delaware
    Inventors: Jeffry M. Ceremony, Daniel Y. Chu, Deepak K. Doshi, Rhoel Rumbaoa, Dennis W. Loring, Paul J. Patt, Cliff Baldwin
  • Patent number: 7595188
    Abstract: An observation apparatus includes a sample tray that holds a container housing a cultured cell and a culture medium and covered with a lid; an observation unit that serves for observation of the cultured cell; and a shifting unit that relatively shifts the sample tray and a light axis of the observation unit along a plane that is orthogonal to the light axis of the observation unit, wherein the sample tray includes a container holding unit that holds the container by utilizing an elastic force, and at least one of the lid and one portion of the lid is made detachable, with the container being held in the sample tray by the container holding unit.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: September 29, 2009
    Assignee: Olympus Corporation
    Inventors: Kazuhiro Hasegawa, Akitsugu Kagayama, Hideaki Endo, Ryuichi Hirano, Atsuhiro Tsuchiya, Kenichi Koyama, Katsuyoshi Yamaguchi
  • Publication number: 20090227033
    Abstract: An analyzer comprising: a first measurement unit for measuring samples; a second measurement unit for measuring samples; a transportation device for transporting samples to the first measurement unit and the second measurement unit; prior sample measurement instructor for instructing to measure a predetermined sample prior to the other samples; and a transportation controller for controlling the transportation device to reserve the transportation of the other samples to the second measurement unit and to perform the other transportation operation, when the prior sample measurement instructor has instructed to measure the predetermined sample by the second measurement unit prior to the other samples, is disclosed. A sample transportation method and a computer program product are also disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 10, 2009
    Inventors: Yuichi Hamada, Daigo Fukuma, Masaharu Shibata