Potato Cell Or Cell Line, Per Se Patents (Class 435/417)
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Publication number: 20120210464Abstract: Improved compositions and methods for controlling pests are disclosed. In particular, novel engineered Cry1Ba (eCry1Ba) proteins having improved toxicity to lepidopteran insect pests are provided. By substituting at least one amino acid in domain I of a Cry1Ba protein an engineered Cry1Ba protein having substantially altered insecticidal properties is designed. Further, a method of making the engineered Cry1Ba proteins and methods of using the ecry1Ba nucleic acid sequences, for example in transgenic plants to express eCry1B proteins to confer protection from insect damage are disclosed.Type: ApplicationFiled: September 27, 2010Publication date: August 16, 2012Applicant: SYNGENTA PARTICIPATIONS AGInventors: Yan Gao, Jared Conville, Jeng Shong Chen
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Publication number: 20120210469Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.Type: ApplicationFiled: April 22, 2011Publication date: August 16, 2012Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Michael WATERHOUSE, Ming-Bo Wang
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Publication number: 20120195901Abstract: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.Type: ApplicationFiled: April 16, 2012Publication date: August 2, 2012Inventors: Roger A. SABBADINI, William A. GARLAND, Genevieve HANSEN, James Stephen SWANEY
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Publication number: 20120180156Abstract: Use of genes homologous to the FT gene of Arabidopsis thaliana of any vegetable species to modulate tuberization in plants that develop tubercles, nucleotide sequence that encodes the potato SP6A protein (homologous to the FT of Arabidopsis thaliana ), genetic constructs that express said gene and the use thereof.Type: ApplicationFiled: April 26, 2010Publication date: July 12, 2012Inventors: Salome Prat, Cristina Navarro, José A. Abelenda, J. E. Van Doorn
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Publication number: 20120171226Abstract: The present disclosure relates to anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies which bind to human HMW-MAA. Such antibodies may be used to treat diseases or disorders characterized by expression of HMW-MAA including cancer, for example, melanoma, basal cell carcinoma, ALL or AML.Type: ApplicationFiled: July 16, 2010Publication date: July 5, 2012Applicant: XOMA Technology Ltd.Inventor: Arnold H. Horwitz
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Publication number: 20120156249Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: ApplicationFiled: August 4, 2010Publication date: June 21, 2012Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Andreas Raab
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Patent number: 8187592Abstract: A mutant prourokinase plasminogen activator (M5) was developed to make prouPA less subject to spontaneous activation during fibrinolysis. C1-inhibitor complexes with tcM5. The effect of C1-inhibitor on fibrinolysis and fibrinogenolysis by M5 was determined. Supplemental C1-inhibitor restores the stability of M5 but not that of prouPA. Clot lysis by M5 with supplemental C1-inhibitor showed no attenuation of the rate of fibrinolysis, whereas fibrinogenolysis was prevented by C1-inhibitor. Due to higher dose tolerance of M5 with C1-inhibitor, the rate of fibrin-specific lysis reached that achievable by nonspecific fibrinolysis without inhibitor. Plasma C1-inhibitor stabilized M5 in plasma by inhibiting tcM5 and thereby non-specific plasminogen activation. At the same time, fibrin-specific plasminogen activation remained unimpaired. This unusual dissociation of effects has significant implications for improving the safety and efficacy of fibrinolysis.Type: GrantFiled: November 16, 2010Date of Patent: May 29, 2012Assignee: Thrombolytic Science, LLCInventors: Victor Gurewich, Ralph Pannell
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Publication number: 20120117867Abstract: A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or a part thereof one or more activities of a polypeptide selected from the group consisting of 26S proteasome-subunit, 50S ribosomal protein L36, Autophagy-related protein, B0050-protein, Branched-chain amino acid permease, Calmodulin, carbon storage regulator, FK506-binding protein, gamma-glutamyl-gamma-aminobutyrate hydrolase, GM02LC38418-protein, Heat stress transcription factor, Mannan polymerase II complex subunit, mitochondrial precursor of Lon protease homolog, MutS protein homolog, phosphate transporter subunit, Protein EFR3, pyruvate kinase, tellurite resistance protein, Xanthine permease, and YAR047C-protein.Type: ApplicationFiled: July 15, 2010Publication date: May 17, 2012Applicant: BASF Plant Science Company GmbHInventors: Janneke Hendriks, Oliver Thimm, Philip Groth, Alexandre Prokoudine, Gerhard Ritte, Claudia König, Resham Kulkarni, Krishna Kollipara
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Publication number: 20120102597Abstract: Process for the production of transgenic plants that have high content and yield of starch and biomass. The starch synthases (SSs) in plants (including SSIV) and glycogen synthase (GlgA) in bacteria catalyse the transfer of the glucosidic part of the ADP-Glucose molecule (the activated donor of glucose) to a pre-existing ?(1, 4)-glucan. However, in contrast to the other SSs, SSIV is able to add glucose units to maltotriose. Also, in contrast to other soluble SSs, SSIV is bound to the starch granule. This invention describes for the first time how to obtain plants that have high levels and yields of starch and biomass as a consequence of the expression of genes coding for SSIV.Type: ApplicationFiled: March 17, 2010Publication date: April 26, 2012Applicant: IDEN BIOTECHNOLOGYInventors: Francisco José Muñoz Pérez, Jun Li, Javier Pozueta-Romero, Sandy Raynaud, Paula Ragel De La Torre, Ángel Mérida Berlanga, Miren Edurne Baroja, Manuel Montero
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Publication number: 20120060235Abstract: Disclosed herein are nucleic acid molecules isolated from coffee (Coffea spp.) comprising sequences that encodes various sucrose metabolizing enzymes, along with their encoded proteins. Specifically, sucrose synthase, sucrose phosphate synthase and sucrose phosphatase enzymes and their encoding polynucleotides from coffee are disclosed. Also disclosed are methods for using these polynucleotides for gene regulation and manipulation of the sugar profile of coffee plants, to influence flavor, aroma, and other features of coffee beans.Type: ApplicationFiled: July 13, 2011Publication date: March 8, 2012Inventors: Isabelle M. PRIVAT, James Gérard McCarthy, Vincent Petiard, Steven D. Tanksley, Chenwei Lin
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Publication number: 20120042411Abstract: An isolated polynucleotide sequence that encodes for a multi domain recombination protein, comprising a donor DNA-Binding domain (BDB); and a chromosomal binding domain (CBD). A plant cell can be transformed by introducing into the cell a first nucleic acid sequence, which comprises a plant nuclear promoter operably linked to a first nucleic acid sequence comprising the stated polynucleotide sequence, and a second nucleic acid sequence, which comprises a donor nucleic acid sequence and at least two flanking sequences capable of binding to a donor binding domain of the protein, the sequences being located adjacent to each end of the donor polynucleotide sequence forming left and right borders thereto.Type: ApplicationFiled: January 25, 2010Publication date: February 16, 2012Inventors: Isabelle Malcuit, Alexander Sorokin
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Publication number: 20120042421Abstract: There is provided a novel promoter useful for altering flow color of plants. The present invention relates to a nucleic acid selected from the group consisting of: (1) a nucleic acid containing the nucleotide sequence indicated in SEQ ID NO. 1; (2) a nucleic acid able to function as a transcriptional regulatory region of perilla anthocyanin 3-acyltransferase, and containing a nucleotide sequence in which the nucleotide sequence indicated in SEQ ID NO. 1 has been modified by addition, deletion and/or substitution of one or several nucleotides; (3) a nucleic acid able to function as a transcriptional regulatory region of perilla anthocyanin 3-acyltransferase, and able to hybridize under high stringent conditions with a nucleic acid consisting of a nucleotide sequence complementary to the nucleotide sequence indicated in SEQ ID NO.Type: ApplicationFiled: March 9, 2010Publication date: February 16, 2012Applicant: SUNTORY HOLDINGS LIMITEDInventors: Yoshikazu Tanaka, Masako Mizutani
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Publication number: 20120030842Abstract: The present invention describes an alternative approach to increase GABA production in prokaryotes or eukaryotes, namely by the insertion of the putrescine catabolic pathway in organisms where the pathway does not exist or has not clearly been identified. The invention describes methods for the use of polynucleotides that encode functional putrescine aminotransferase (PAT) and gamma-aminobutyricaldehyde dehydrogenase (GABAlde DeHase) polypeptides in plants to increase GABA production. The preferred embodiment of the invention is in plants but other organisms may be used. Changes in GABA availability will improve growth and increase tolerance to biotic and abiotic stress.Type: ApplicationFiled: October 17, 2011Publication date: February 2, 2012Applicant: PLANT SENSORY SYSTEMS, LLCInventors: Frank Turano, Kathleen Turano
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Publication number: 20120020940Abstract: The present invention relates to a peptide comprising or consisting of the following amino acid sequence: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12 (formula II), wherein A0 is a hydrophobic amino acid residue or is absent; A1, A4, A7, A8, A12 each are a hydrophobic amino acid residue; and A2, A6, A9, A10 each are a basic amino acid residue; A5 is an alanine or a basic amino acid residue; A3, A11 each are a basic amino acid residue, or a hydrophobic amino acid residue; or a peptidomimetic thereof; wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, isoleucine, valine, methionine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial and/or antiviral activity.Type: ApplicationFiled: September 24, 2009Publication date: January 26, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Jörg Durner, Christian Lindermayr, Ruth Brack-Werner
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Publication number: 20120014969Abstract: Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.Type: ApplicationFiled: July 12, 2011Publication date: January 19, 2012Inventors: Robert Akita, Mark Sliwkowski
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Publication number: 20120017333Abstract: The present invention relates to plant cells and plants, which are genetically modified, whereby the genetic modification leads to an increase in the activity of a starch-phosphorylating OK1 protein in comparison to the corresponding wild type plant cells or wild type plants that have not been genetically modified. In addition, the present invention concerns means and methods for the manufacture of such plant cells and plants. These types of plant cells and plants synthesise a modified starch. Therefore, the present invention also concerns the starches synthesised from the plant cells and plants according to the invention, methods for manufacturing these starches, and the manufacture of starch derivatives of these modified starches, as well as flours containing starches according to the invention. Furthermore, the present invention also relates to nucleic acids, coding starch-phosphorylating OK1 proteins, vectors, host cells, plant cells, and plants containing such nucleic acid molecules.Type: ApplicationFiled: June 30, 2011Publication date: January 19, 2012Applicant: BAYER CROPSCIENCE AGInventors: CLAUS FROHBERG, OLIVER KOETTING, GERHARD RITTE, MARTIN STEUP
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Publication number: 20120010387Abstract: Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required.Type: ApplicationFiled: March 2, 2011Publication date: January 12, 2012Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Rinpei NIWA, Mami TSUCHIYA
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Publication number: 20110321187Abstract: Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof.Type: ApplicationFiled: November 25, 2009Publication date: December 29, 2011Applicant: Algentech SASInventors: Isabelle Malcuit, Alexander Sorokin
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Publication number: 20110321196Abstract: The present invention pertains transgenic plant cells and mature plants comprising Oxidoreductase Stress Related Proteins (ORSRP) resulting in increased tolerance and/or resistance to environmental stress as compared to non-transformed wild type cells and methods of producing such plant cells or plants. Further object of the present invention are isolated ORSRPs or ORSRP encoding nucleic acids from plants.Type: ApplicationFiled: April 29, 2011Publication date: December 29, 2011Applicant: BASF Plant Science GmbHInventors: Agnes Chardonnens, Piotr Puzio
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Publication number: 20110301073Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.Type: ApplicationFiled: May 17, 2011Publication date: December 8, 2011Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
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Publication number: 20110296551Abstract: Method for heterologous RNA species and protein production in plant cell mitochondria comprising introducing into plant cells nucleic acid components that encode heterologous proteins/RNAS under the control of promoters operative in mitochondria, vectors, host cells, plants and uses thereof.Type: ApplicationFiled: November 25, 2009Publication date: December 1, 2011Applicant: ALGENTECH SASInventors: Isabelle Malcuit, Alexander Sorokin
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Publication number: 20110293632Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.Type: ApplicationFiled: November 30, 2007Publication date: December 1, 2011Applicant: Genentech, Inc.Inventor: Leonard Presta
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Publication number: 20110283377Abstract: The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ECS) operable in monocots and/or dicots. For example, (i) an isolated nucleic acid may comprise an ECS (e.g., a sugarcane bacilliform virus promoter) and, optionally, an exogenous nucleic acid (ExNA) operably linked to the ECS; (ii) an expression vector may comprise an ECS; an ExNA; and, optionally, a 3? termination sequence, wherein the ECS has promoter activity sufficient to express the ExNA in at least one monocot and at least one dicot; (iii) a microorganism, plant cell, or plant may comprise an isolated nucleic acid; (iv) a method for constitutively expressing an ExNA in a plant (e.g.Type: ApplicationFiled: May 10, 2011Publication date: November 17, 2011Inventors: T. Erik Mirkov, Jong Won Park, San-Ji Gao
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Publication number: 20110274692Abstract: The present invention provides polypeptide binding agents, e.g. antibodies, that exhibit the ability to kinetically modulate the binding and signaling of biological signaling complexes, e.g., receptor-ligand complexes; methods of identifying such polypeptide binding agents, methods of making such polypeptide binding agents, compositions comprising such polypeptide binding agents, and methods of using such polypeptide binding agents.Type: ApplicationFiled: September 24, 2010Publication date: November 10, 2011Applicant: XOMA TECHNOLOGY LTD.Inventors: Mark L. White, Marina Roell, John Corbin, Robert Bauer, Daniel Bedinger
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Publication number: 20110277179Abstract: This invention relates generally to a plant cell with enhanced nitrogen use efficiency and/or increased biomass production as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of polypeptides associated with enhanced nitrogen use efficiency in plants.Type: ApplicationFiled: September 17, 2008Publication date: November 10, 2011Applicant: BASF Plant Science GmbHInventors: Piotr Puzio, Oliver Bl¿sing, Oliver Thimm, Gerhard Ritte, Hardy Sch¿n
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Publication number: 20110252509Abstract: This invention relates generally to a method for producing a transgenic cell with increased gamma-aminobutyric acid (GABA) content as compared to a corresponding non-transformed wild type cell.Type: ApplicationFiled: October 23, 2009Publication date: October 13, 2011Applicant: BASF Plant Sceince GmbHInventors: Janneke Hendriks, Hardy Schön, Oliver Thimm, Volker Haake, Gunnar Plesch, Piotr Puzio, Astrid Blau, Michael Manfred Herold, Birgit Wendel, Beate Kamlage, Florian Schauwecker
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Publication number: 20110252491Abstract: The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel chimeric promoters comprising combinations of plant enhancer elements and plant promoters. The present invention also provides DNA constructs; transgenic cells, plants, and seeds containing these novel chimeric promoters; and methods for preparing and using the same.Type: ApplicationFiled: September 25, 2009Publication date: October 13, 2011Inventor: Stanislaw Flasinski
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Publication number: 20110231961Abstract: The present invention provides metabolic regulators, which are proteins (such as fusion proteins, truncated proteins or full-length proteins) that bind to specific metabolites and which can be used to control the availability of the metabolites in cells, particularly plant cells. Proteins of the invention include one or more metabolic regulator proteins, can be truncated or full length, can further comprise a transmembrane domain or lipoylation site or can further comprise a transit peptide. Metabolic regulators of the invention can be soluble, e.g., cytosolic soluble, can be anchored to a biological membrane or can be organelle targeted or apoplastic targeted. The present invention also provides nucleic acid molecules encoding the metabolic regulators, methods of making the nucleic acid molecules, methods for making transformed organisms, including plants, photosynthetic organisms, microbes, invertebrates, and vertebrates, and methods for controlling availability of metabolites to a host cell.Type: ApplicationFiled: April 27, 2011Publication date: September 22, 2011Applicant: PLANT SENSORY SYSTEMS, LLCInventors: Frank Turano, Kathleen Turano
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Publication number: 20110225673Abstract: The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel chimeric promoters comprising combinations of plant viral enhancer elements and plant promoters. The present invention also provides DNA constructs; transgenic cells, plants, and seeds containing these novel chimeric promoters; and methods for preparing and using the same.Type: ApplicationFiled: September 21, 2009Publication date: September 15, 2011Inventor: Stanislaw Flasinski
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Publication number: 20110223667Abstract: CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.Type: ApplicationFiled: May 13, 2011Publication date: September 15, 2011Applicant: The Salk Institute for Biological StudiesInventors: Florence Pojer, Joseph P. Noel, Elise Larsen, Marianne Bowman, Stephane Richard
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Publication number: 20110212541Abstract: Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target polar lipids on a host (plant or animal) cell as a prerequisite for translocation of the pathogenic effector proteins into the cell. Translocation is prevented by binding blocking compounds to one or more motifs of the effector protein or to the lipid ligands of the host cell. The blocking compounds include synthetic or naturally occurring polypeptides which bind the polar lipids or the motifs, various polar lipids, the hydrophilic head-groups of polar lipids, etc. Suitable blocking compounds can be identified by assays demonstrating binding to the motifs or to the target polar lipids.Type: ApplicationFiled: November 11, 2010Publication date: September 1, 2011Applicant: Virginia Tech Intellectual Properties, Inc.Inventors: Brett Tyler, Shiv Kale, Vincenzo Antignani
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Publication number: 20110203019Abstract: The present invention describes an alternative approach to increase GABA production in prokaryotes or eukaryotes, namely by the insertion of the putrescine catabolic pathway in organisms where the pathway does not exist or has not clearly been identified. The invention describes methods for the use of polynucleotides that encode functional putrescine aminotransferase (PAT) and gamma-aminobutyricaldehyde dehydrogenase (GABAlde DeHase) polypeptides in plants to increase GABA production. The preferred embodiment of the invention is in plants but other organisms may be used. Changes in GABA availability will improve growth and increase tolerance to biotic and abiotic stress.Type: ApplicationFiled: April 27, 2011Publication date: August 18, 2011Applicant: PLANT SENSORY SYSTEMS, LLCInventors: Frank Turano, Kathleen Turano
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Patent number: 7989616Abstract: This invention relates to modified starches having an elevated content of phosphate and an elevated content of amylose.Type: GrantFiled: April 7, 2006Date of Patent: August 2, 2011Assignee: Bayer Cropscience AGInventors: Stephan Soyka, Claus Frohberg
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Publication number: 20110173715Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. In particular, this invention relates to nucleic acid sequences encoding proteins that confer drought, heat, cold, and/or salt tolerance to plants.Type: ApplicationFiled: September 23, 2005Publication date: July 14, 2011Applicant: BASF PLANT SCIENCE GMBHInventors: Piotr Puzio, Agnes Chardonnens, Harry Wild, Gunnar Plesch, Bryan McKersie
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Publication number: 20110162114Abstract: The invention relates to a method for producing a transformed plant cell. More particularly, the method involves the transformation of a plant cell with a Transformation Cassette which is targeted to plant plastids and which comprises a selection gene, for example isopentenyl transferase (IPT), and a transgene. After selection for transformed plastids, expression of a recombinase is induced in the plant cell, which leads to the excision of the selection gene from the plastid and the expression of the transgene in the plastid. The invention also provides cells and plants comprising the Transformation Cassette.Type: ApplicationFiled: June 12, 2009Publication date: June 30, 2011Inventors: Simon Geir Moller, Nam-Hai Chua, Jodi Maple
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Publication number: 20110154530Abstract: This invention relates generally to a plant cell with increased yield, preferably under condition of transient and repetitive abiotic stress as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of Yield-Related Proteins (YRP) and/or Yield and Stress-Related Proteins (YSRP) in plants.Type: ApplicationFiled: August 19, 2009Publication date: June 23, 2011Applicant: BASF Plant Science GmbHInventors: Oliver Bläsing, Oliver Thimm, Piotr Puzio
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Publication number: 20110119793Abstract: The present invention provides novel promoters for use in plants. Specifically, the present invention provides novel enhanced plant promoters. The present invention also provides DNA constructs; transgenic cells, plants, and seeds containing these novel promoters; and methods for preparing and using the same.Type: ApplicationFiled: March 17, 2009Publication date: May 19, 2011Inventors: Andrew M. Mroczka, Monica P. Ravanello, Toni Voelker, Nicholas W. Wagner
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Publication number: 20110107446Abstract: The present invention is directed to controlling nematode infestation. The invention discloses methods and compositions for use in controlling nematode infestation by providing recombinant DNA molecules to the cells of a plant in order to achieve a reduction in nematode infestation. The invention is also directed to methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from nematode infestation.Type: ApplicationFiled: February 9, 2009Publication date: May 5, 2011Inventors: John D. Bradley, Catherine C. Baublite, Michael J. Crawford, Stanislaw Flasinski, Deryck J. Williams
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Publication number: 20110099668Abstract: The present invention provides, in part, GLK1 nucleic acid molecules and polypeptides that can be used to confer resistance to a pathogen in a plant. The present invention also provides methods of detecting disease resistance genes and plants.Type: ApplicationFiled: May 1, 2008Publication date: April 28, 2011Inventors: Jasbir Singh, Ghislaine C. Allard, Leonid V. Savitch, Rajagopal Subramaniam
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Publication number: 20110097794Abstract: The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.Type: ApplicationFiled: September 23, 2010Publication date: April 28, 2011Applicant: Intrexon CorporationInventors: Jianzhong Zhang, Dean Ervin Cress, Subba Reddy Palli, Tarlochan Singh Dhadialla
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Publication number: 20110078833Abstract: The present invention provides non-coding regulatory element polynucleotide molecules isolated from the lipid transfer protein (LTP) gene of Oryza sativa and useful for expressing transgenes in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the Oryza sativa regulatory polynucleotide sequences, and methods for preparing and using the same.Type: ApplicationFiled: September 17, 2010Publication date: March 31, 2011Inventors: Wei WU, Qi WANG, James MORRELL, Linda LUTFIYYA, Maolong LU, Zhaolong LI, Ping LI, Michelle LACY, David KOVALIC, Yongwei CAO, Andrey BOUKHAROV, Stanislaw FLASINSKI, Peter T. HAJDUKIEWICZ
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Publication number: 20110059525Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.Type: ApplicationFiled: June 17, 2010Publication date: March 10, 2011Applicant: INTREXON CORPORATIONInventors: SUBBA REDDY PALLI, MARIANNA ZINOVJEVNA KAPITSKAYA, DEAN ERVIN CRESS
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Publication number: 20110055968Abstract: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.Type: ApplicationFiled: July 23, 2009Publication date: March 3, 2011Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DAVID CERF, RUTH CONG, MICHAEL FREEMAN, KEVIN E. McBRIDE, TAKASHI YAMAMOTO
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Patent number: 7879338Abstract: The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.Type: GrantFiled: July 21, 2004Date of Patent: February 1, 2011Assignee: Boyce Thompson Institute for Plant ResearchInventors: William D.O. Hamilton, Koen Hellendoorn, Timothy D. Jones, Dwayne D. Kirk, Hugh S. Mason, Xiuren Zhang, Charles J. Arntzen
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Publication number: 20110023180Abstract: Novel hydroxyphenyl pyruvate dioxygenase (HPPD) polypeptides, variants and fragments thereof, as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring HPPD herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for HPPD polypeptides, as well as polynucleotides encoding the same. Methods for the production and use of HPPD herbicide resistant plants that express these novel HPPD polypeptides, methods for selectively controlling weeds in a field at a crop locus, and methods for the assay, characterization, identification and selection of these novel HPPDs are also provided.Type: ApplicationFiled: July 16, 2010Publication date: January 27, 2011Applicant: Syngenta Participations AGInventors: Timothy Robert HAWKES, Michael Phillip Langford, Russell Colin Viner, Bernardus Theodorus Maria Vernooij, Richard Dale, Shradha Singh, Vance Kramer
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Publication number: 20110010800Abstract: The present invention disclosed herein provides a method for producing a plant with increased yield as compared to a corresponding wild type plant comprising increasing or generating one or more activities in a plant or a part thereof. The present invention further relates to nucleic acids enhancing or improving one or more traits of a transgenic plant, and cells, progenies, seeds and pollen derived from such plants or parts, as well as methods of making and methods of using such plant cell(s) or plant(s), progenies, seed(s) or pollen. Particularly, said improved trait(s) are manifested in an increased yield, preferably by improving one or more yield-related trait(s).Type: ApplicationFiled: February 27, 2009Publication date: January 13, 2011Applicant: BASF PLANT SCIENCE GMBHInventors: Gerhard Ritte, Oliver Bläsing, Oliver Thimm
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Publication number: 20110010801Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences of interest in a plant. Compositions are novel nucleotide sequences for a pericarp-preferred promoter associated with the maize cystatin coding region. A method for expressing a nucleotide sequence of interest in a plant using the regulatory sequence disclosed herein is provided.Type: ApplicationFiled: April 30, 2010Publication date: January 13, 2011Applicant: Pioneer Hi-Bred International, Inc.Inventor: Shane Abbitt
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Publication number: 20100293665Abstract: This invention relates generally to transformed plant cells and plants or parts thereof comprising an inactivated or down-regulated gene resulting an increased yield, in particular an increased yield-related trait, e.g. an increased nutrient use efficiency, such as an enhanced nitrogen use efficiency and/or increased biomass production as compared to, e.g. non-transformed, wild type cells and methods of producing such plant cells or plants or parts thereof.Type: ApplicationFiled: December 19, 2008Publication date: November 18, 2010Applicant: BASF Plant Science GmbHInventors: Piotr Puzio, Oliver Bläsing, Oliver Thimm
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Publication number: 20100281569Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences of interest in a plant. Compositions are novel nucleotide sequences for a seed-preferred promoter associated with the maize 17 KD OLE (17 kilodalton oleosin) coding region. A method for expressing a nucleotide sequence of interest in a plant using the regulatory sequence disclosed herein is provided.Type: ApplicationFiled: May 4, 2010Publication date: November 4, 2010Applicant: Pioneer Hi-Bred International, Inc.Inventors: Shane Abbitt, Jinrui Shi
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Publication number: 20100281572Abstract: Compositions and methods for providing nematode resistance are provided. One aspect provides transgenic plants or cells comprising an inhibitory nucleic acid specific for one or more nematode esophageal polypeptides. Other aspects provide transgenic plants or cells resistant to at least two different root-knot nematode species.Type: ApplicationFiled: July 16, 2010Publication date: November 4, 2010Inventors: Richard S. Hussey, Guozhong Huang