Potato Cell Or Cell Line, Per Se Patents (Class 435/417)
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Patent number: 6320101Abstract: A method of enhancing inorganic carbon fixation by a photosynthetic organism. The method is effected by transforming cells of the photosynthetic organism with an expressible polynucleotide encoding a polypeptide having a bicarbonate transporter activity. Preferably, the polynucleotide further includes a plant promoter. Sequences and constructs for implementing the method are also described.Type: GrantFiled: June 14, 1999Date of Patent: November 20, 2001Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Aaron Kaplan, Judy Lieman-Hurwitz, Daniella Schatz, Ron Mittler, Michal Ronen-Tarazi, David J. Bonfil
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Patent number: 6297428Abstract: The present invention concerns a method for inducing resistance to a virus comprising a TGB3 sequence with the proviso that it is not the potato virus X, into a plant cell or plant, comprising the following steps: preparing a nucleic acid construct comprising a nucleic acid sequence corresponding to at least 70% of the nucleic acid sequence of TGB3 of said virus or its corresponding cDNA, being operably linked to one or more regulatory sequence(s) active in a plant, transforming a plant cell with the nucleic acid construct, and possibly regenerating a transgenic plant from the transformed plant cell. The present invention is also related to the plant obtained.Type: GrantFiled: February 8, 1999Date of Patent: October 2, 2001Assignee: SES Europe N.V./S.A.Inventors: Hubert Guilley, Gerard Jonard, Ken Richards, Salah Bouzoubaa, Claudine Bleykasten-Grosshans, Guy Weyens, Marc Lefebvre
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Patent number: 6284947Abstract: The invention provides novel methods of using viral replicase polypeptides and polynucleotides. Included are methods for increasing transformation frequencies, increasing crop yield, providing a positive growth advantage, modulating cell division, transiently modulating cell division, and for providing a means of positive selection.Type: GrantFiled: February 25, 1999Date of Patent: September 4, 2001Assignee: Pioneer Hi-Bred International, Inc.Inventors: William J. Gordon-Kamm, Keith S. Lowe, Matthew A. Bailey, Carolyn A. Gregory, George J. Hoerster, Brian A. Larkins, Brian R. Dilkes, Ronald Burnett, Young Min Woo
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Patent number: 6255563Abstract: Nucleic acid molecules are described, which encode debranching enzymes from potato, as well as transgenic plant cells and plants in which an amylopectin with modified properties is synthesized due to the expression of a debranching enzyme from potato or due to the inhibition of such an endogeneous debranching enzyme activity.Type: GrantFiled: November 5, 1998Date of Patent: July 3, 2001Assignee: PlantTec Biotechnologie GmbHInventors: Michael Emmermann, Jens Kossmann
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Patent number: 6255562Abstract: The present invention relates to a process for preparing recombinantly modified, inulin-producing plants, to the DNA sequences which are used in this context and to the transformed plants which are obtained.Type: GrantFiled: November 3, 1998Date of Patent: July 3, 2001Assignees: Sudzucker Aktiengesellschaft, KWS Saat AGInventors: Arnd G. Heyer, Regina Wendenburg
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Patent number: 6255561Abstract: Nucleic acid molecules are described, which encode debranching enzymes from maize, as well as transgenic plant cells and plants in which an amylopectin with modified properties is synthesized due to the expression of a debranching enzyme from maize or due to the inhibition of such an endogeneous debranching enzyme activity.Type: GrantFiled: September 4, 1998Date of Patent: July 3, 2001Assignee: PlantTec Biotechnologie GmbHInventors: Jens Kossman, Lothar Willmitzer, Michael Emmermann
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Patent number: 6242568Abstract: The present invention provides zinc finger nucleotide binding polypeptide variants that have at least two zinc finger modules that bind to a target cellular nucleotide sequence and modulate the transcriptional function of the cellular nucleotide sequence. Also provided are methods of use of such zinc finger nucleotide binding polypeptide variants and methods for isolating the same using expression libraries encoding the polypeptide variants containing randomized substitutions of amino acids. Exemplary zinc finger nucleotide binding polypeptide variants of the invention include two cysteines and two histidines whereby both cysteines are amino proximal to both histidines.Type: GrantFiled: December 30, 1996Date of Patent: June 5, 2001Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, III, Joel M. Gottesfeld, Peter E. Wright
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Patent number: 6232526Abstract: The current invention provides the maize A3 promoter and actin 2 intron. Compositions comprising these sequences are described, as well as transformation constructs derived therefrom. Further provided are methods for the expression of transgenes in plants comprising the use of these sequences. The methods of the invention include the direct creation of transgenic plants with the A3 promoter directly by genetic transformation, as well as by plant breeding methods. The sequences of the invention represent a valuable new tool for the creation of transgenic plants, preferably having one or more added beneficial characteristics.Type: GrantFiled: May 14, 1999Date of Patent: May 15, 2001Assignee: Dekalb Genetics Corp.Inventors: David McElroy, Alan L. Kriz, Emil M. Orozco, Jr., Matt Griffor
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Patent number: 6215042Abstract: Plasmids are described having DNA sequences that after insertion into the genome of the plants cause changes in the carbohydrate concentration and the carbohydrate composition in regenerated plants. These changes can be obtained from a sequence of a branching enzyme that is located on these plasmids. This branching enzyme alters the amylose/amylopectin ratio in starch of the plants, especially in commercially used plants.Type: GrantFiled: August 13, 1993Date of Patent: April 10, 2001Assignee: Hoeschst Schering Agrevo GmbHInventors: Lothar Willmitzer, Uwe Sonnewald, Jens Kossmann, Bernd Müller-Röber, Richard G. F. Visser, Evert Jacobsen
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Patent number: 6204434Abstract: Novel isolated DNA sequences associated with the lignin biosynthetic pathway are provided, together with DNA constructs including such sequences. Methods for the modulation of lignin content and structure in plants and methods for producing plants having altered lignin content and structure, are also disclosed, the methods comprising and incorporating one or more of the polynucleotides disclosed herein into the genome of a plant.Type: GrantFiled: December 14, 1998Date of Patent: March 20, 2001Assignees: Genesis Research & Development Corporation Limited, Fletcher Challenge Forests LimitedInventors: Leonard N. Bloksberg, Ilkka Havukkala, Alastair Grierson
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Patent number: 6169226Abstract: The present invention relates to an amino acid sequence of second starch branching enzyme (SBE II) of potato and a fragment thereof as well as to the corresponding isolated DNA sequences. Furthermore, the invention relates to vectors comprising such an isolated DNA sequence, to processes for production of transgenic potatoes, and to the use of said potatoes for the production of starch. The starch obtained will show a changed pattern of branching of amylopectin as well as a changed amylose/amylopectin ratio.Type: GrantFiled: May 29, 1998Date of Patent: January 2, 2001Assignee: Amylogene HBInventors: Bo Ek, Jamshid Khosnoodi, Clas-Tomas Larsson, Håkan Larsson, Lars Rask
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Patent number: 6166295Abstract: The NDR1 gene of Arabidopsis thaliana has been cloned and sequenced. NDR1 is necessary for plant defense mediated by numerous disease resistance gene m products. Expression of NDR1 in transgenic plants confers resistance to a broad variety of plant pathogens.Type: GrantFiled: November 21, 1997Date of Patent: December 26, 2000Assignee: The Regents of the University of CaliforniaInventors: Brian J. Staskawics, Karen S. Century, Allan Shapiro, Peter P. Repetti, Douglas Dahlbeck
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Patent number: 6153420Abstract: A novel serine protease is disclosed. The protease comprises a sequence of amino acid residues that is at least 95% identical to SEQ ID NO:2 from Ile, residue 111, through Asn, residue 373. Also disclosed are polynucleotide molecules encoding the protease, expression vectors containg the polynucleotides, cultured cells containing the expression vectors, and methods of making the protease. The protease can be used, inter alia, within industrial processes to degrade unwanted proteins or alter the characteristics of protein-containing compositions.Type: GrantFiled: May 4, 1998Date of Patent: November 28, 2000Assignee: ZymoGenetics, Inc.Inventor: Paul O. Sheppard
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Patent number: 6133033Abstract: A first method is provided for in vitro selection of Lemhi and Russet Burbank potatoes for blackspot resistance using plant tissue culturing techniques. A second method is provided using at least one melanin precursor added to the tissue culturing media. The blackspot resistant potatoes produced from such methods are also provided.Type: GrantFiled: May 4, 1999Date of Patent: October 17, 2000Assignee: J. R. Simplot CompanyInventors: Gary Allen Secor, Raymond J. Taylor, Dennis Lee Bidney, Cheryl Louise Ruby
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Patent number: 6127602Abstract: The present invention provides methods of making paper utilizing glucans, produced by glucosyltransferase D enzymes of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to the hydroxethyl modified starch and are particularly useful in the sizing and coating steps of paper manufacture. The present glucans also exhibit thermoplastic properties and impart gloss to the paper during the coating step. In particular, the present invention provides plant cells and plants transformed with Streptococcus mutans genes encoding wild-type or mutant glucosyltransferase D enzymes.Type: GrantFiled: January 16, 1998Date of Patent: October 3, 2000Assignee: Pioneer Hi-Bred International, Inc.Inventor: Scott E. Nichols
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Patent number: 6127603Abstract: The present invention provides methods of making paper utilizing glucans, produced by the glucosyltransferase C enzyme of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to the hydroxethyl modified starch and are particularly useful in the coating step of paper manufacture. The present glucans also exhibit thermoplastic properties and impart gloss to the paper during the coating step. In particular, the present invention provides plant cells and plants transformed with the Streptococcus mutans gene encoding the glucosyltransferase C enzyme.Type: GrantFiled: January 20, 1998Date of Patent: October 3, 2000Assignee: Pioneer Hi-Bred International, Inc.Inventor: Scott E. Nichols
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Patent number: 6117665Abstract: The invention describes DNA molecules which code for plant proteins having the biological activity of a debranching enzyme. Furthermore described are transgenic plant cells and plants having reduced or increased debranching enzyme activity, as well as modified starch isolatable from transgenic cells and plants.Type: GrantFiled: November 25, 1997Date of Patent: September 12, 2000Inventors: Jens Kossmann, Michael Emmermann, Ivar Virgin, Andreas Renz
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Patent number: 6100092Abstract: Products and methods for amplifying target nucleic acids using cells derived from plants are disclosed. The products include nucleic acids containing a plant active Amplification Promoting Sequence (APS) and the methods exploit these products in amplifying target nucleic acids. Also disclosed are methods for amplifying target nucleic acids that express an encoded product, and the recovery of that expression product. The methods of the invention minimize operator intervention and exploit solar energy and the minimal nutrient needs of photoautotrophic organisms to provide inexpensive and indefinitely sustainable methods for producing a variety of amplified target nucleic acids and encoded products such as polypeptides.Type: GrantFiled: June 15, 1998Date of Patent: August 8, 2000Assignee: Board of Trustees, Rutgers The State University of New JerseyInventors: Mykola Borysyuk, Lyudmyla Borysyuk, Ilya Raskin
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Patent number: 6087559Abstract: The present invention provides methods of making paper utilizing glucans, produced by glucosyltransferase B enzymes of the species Streptococcus mutans, instead of modified starches. The present glucans are functionally similar to the hydroxethyl modified starch and are particularly useful in the sizing and coating steps of paper manufacture. The present glucans also exhibit thermoplastic properties and impart gloss to the paper during the coating step. In particular, the present invention provides plant cells and plants transformed with Streptococcus mutans genes encoding wild-type or mutant glucosyltransferase B enzymes.Type: GrantFiled: January 16, 1998Date of Patent: July 11, 2000Assignee: Pioneer Hi-Bred International, Inc.Inventor: Scott E. Nichols
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Patent number: 6060312Abstract: A first method is provided for in vitro selection of Lemhi and Russet Burbank potatoes for blackspot resistance using plant tissue culturing techniques. A second method is provided using at least one melanin precursor added to the tissue culturing media. The blackspot resistant potatoes produced from such methods are also provided.Type: GrantFiled: June 17, 1991Date of Patent: May 9, 2000Assignee: J.R. Simplot CompanyInventors: Gary Allen Secor, Raymond J. Taylor, Dennis Lee Bidney, Cheryl Louise Ruby
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Patent number: 6057493Abstract: Plasmids containing DNA sequences which when inserted into the genome of a plant modify the carbohydrate or protein concentration and the carbohydrate or protein composition, and plant cells and plants that contain these plasmids.DNA sequences located in plasmids reduce ADP-glucose-pyrophosphorylase activity in the plant and thereby the starch concentration, while at the same time increase the mono- and oligosaccharide concentration. Other DNA sequences in plasmids reduce or increase the protein concentration. Plants that contain these plasmids are suitable inter alia for the extraction of sugar or as protein-enriched food or fodder.Type: GrantFiled: January 5, 1994Date of Patent: May 2, 2000Assignee: Hoechst Schering AgrEvo GmbHInventors: Lothar Willmitzer, Uwe Sonnewald, Rainer Hofgen, Jens Kossmann, Bernd Muller
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Patent number: 6037524Abstract: A promoter derived from an SHH gene, especially the SHH gene of Arabidopsis thaliana which is capable of directing expression on a variety of operator genes in both monocotyledonous and dicotyledonous plants. The promoter of the invention may be used for directing expression of pathogen resistance genes to disease or wound sites.Type: GrantFiled: October 9, 1997Date of Patent: March 14, 2000Assignee: Zeneca LimitedInventors: Andrew James Greenland, John Draper, Mark Skipsey, Simon Warner
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Patent number: 6018102Abstract: Stabilized ubiquitin-lytic peptide fusion polypeptides and a method of making the same by sub-cloning nucleic acid sequences coding for lytic peptides into a plasmid vector comprising a promoter and ubiquitin polypeptide coding sequence, wherein the ubiquitin polypeptide sequence is linked to the 5' end of the lytic peptide nucleic acid sequence and is translated as a fusion polypeptide.Type: GrantFiled: February 19, 1997Date of Patent: January 25, 2000Assignees: Demegen, Inc., The United States of America represented by the Secretary of AgricultureInventors: Joan Garbarino, Jesse Jaynes, William Belknap
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Patent number: 5981181Abstract: There are described DNA sequences, that contain the coding region of an oligosaccharide transporter, whose introduction in a plant genome modifies the formation and transfer of storage materials in transgenic plants, plasmids, bacteria and plants containing these DNA sequences, a process for the preparation and transformation of yeast strains, that makes possible the identification of the DNA sequences of the plant oligosaccharide transporter of the invention, as well as the use of DNA sequences of the invention.Type: GrantFiled: January 21, 1997Date of Patent: November 9, 1999Assignee: Hoechst Schering AgrEvo GmbHInventors: Wolf-Bernd Frommer, Jorg Riesmeier
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Patent number: 5969214Abstract: The present invention is directed to the modification of reserve polysaccharides in plants. Specifically, it has been found that host plants can be successfully transformed with a nucleic acid sequence capable of expressing a chimeric reserve polysaccharide modification enzyme gene sequence which will synthesize novel reserve polysaccharides in plants or convert the transformed plant's endogenous starch reserves to novel starch degradation products.Type: GrantFiled: June 7, 1995Date of Patent: October 19, 1999Assignee: Calgene, Inc.Inventors: David M. Stalker, Christine K. Shewmaker
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Patent number: 5939288Abstract: Provided herein are signal peptides, and constructs and vectors having signal peptides, as well as methods of using signal peptides to deliver proteins into secretory material. The invention facilitates the purification of recombinant proteins. Also provided are a new class of proteins called nectarins, from which the signal peptides may be derived. Additionally, the nectarins possess oxalate oxidase activity and have utility as agents for treating diseases or conditions relating to abnormal oxalate deposition or metabolism or as diagnostics for measuring oxalate concentrations in specimens.Type: GrantFiled: June 7, 1995Date of Patent: August 17, 1999Assignee: Iowa State University Research Foundation, Inc.Inventor: Robert Thornburg
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Patent number: 5859343Abstract: Recombinant materials for the production of practical amounts of the sweet protein, mabinlin are provided. In addition, transgenic plants which have inherently sweetened edible parts result from modifying native plants containing edible parts to express the mabinlin gene. Single-chain forms of this protein which retain their sweetening property are also provided.Type: GrantFiled: June 21, 1996Date of Patent: January 12, 1999Assignee: University of HawaiiInventors: Samuel S. M. Sun, Liwen Xiong, Zhong Hu, Hang Chen
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Patent number: 5856157Abstract: Isolation and characterization of a novel plant fatty acid desaturase cDNA that encodes a .DELTA..sup.9 14:0-ACP desaturase. Expression of the .DELTA..sup.9 14:0-ACP desaturase is a critical factor for pest resistance in plants of the genus Pelargonium and other plants generally; the desaturase gene is also useful in other contexts and for other purposes such as increasing the percentage of unsaturated fatty acids in oil-producing crops such as soybeans, rapeseed, maize, sunflower, safflower, cotton, cuphea, peanut, coconut and oil-palm, as well as increasing the percentage of unsaturated fatty acids in other plants generally.Type: GrantFiled: June 4, 1997Date of Patent: January 5, 1999Assignee: The Penn State Research FoundationInventors: Richard Craig, June I. Medford, Ralph O. Mumma, Diana L. Cox-Foster, David Schultz
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Patent number: 5792937Abstract: A DNA sequence encoding a PVX replicase gene obtained from ORF1 of a PVX genome is provided. A plant gene containing the PVX replicase coding region is also provided as is a truncated derivative of the PVX replicase gene. A PVX replicase gene is inserted into a plant to confer resistance to the plant against PVX infection when the PVX replicase gene is sufficiently expressed.Type: GrantFiled: February 21, 1997Date of Patent: August 11, 1998Assignee: Monsanto CompanyInventors: Carl Joseph Braun, III, Cynthia Lou Hemenway, Nilgun Ereken Tumer
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Patent number: 5750496Abstract: A method for controlling infections caused by Cryptosporidium parvum. The method comprises using protease inhibiting compounds, preferably serine protease inhibitors, to inhibit excystation, invasion, and parasite maturation and development. The method is directed to therapeutic treatment of mammals, such as humans, exposed to C. parvum, and additionally as a prophylactic treatment in immunocompromised subjects at high risk for contracting cryptosporidiosis.Type: GrantFiled: August 12, 1996Date of Patent: May 12, 1998Assignee: Utah State UniversityInventors: John R. Forney, Shiguang Yang, Mark C. Healey
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Patent number: 5750875Abstract: The present invention is directed to the modification of reserve polysaccharides in plants. Specifically, it has been found that host plants can be successfully transformed with a nucleic acid sequence capable of expressing a chimeric reserve polysaccharide modification enzyme gene sequence which will synthesize novel reserve polysaccharides in plants or convert the transformed plant's endogenous starch reserves to novel starch degradation products.Type: GrantFiled: June 6, 1995Date of Patent: May 12, 1998Inventors: David M. Stalker, Christine K. Shewmaker, Janette V. Oakes
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Patent number: 5750876Abstract: A method of producing plant products containing modified starch content, including higher ratios of amylose to amylopectin, increase in intermediate material, or amylopectin having fewer branches or altered branching pattern. Also provided are DNA constructs and transformed plant cells useful in that method. The preferred method uses isoamylase from a Flavobacterium sp., more preferably in combination with a gene encoding ADPglucose pyrophosphorylase. Also disclosed are the gene from Flavobacterium sp. and transformed bacterial and plant cells containing a derivative thereof.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: Monsanto CompanyInventors: Gerard Francis Barry, Ganesh Murthy Kishore, Bradley Martin Krohn
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Patent number: 5648599Abstract: The present invention relates to an isolated gene fragment which confers disease resistance to plants by responding to an avirulence gene in plant pathogens. The gene fragment encodes for protein kinase, particularly serine/threonine kinase. The gene can be cloned into an expression vector to produce a recombinant DNA expression system suitable for insertion into cells to form a transgenic plant transformed with that gene fragment. Also disclosed is a process of conferring disease resistance to plants by growing plant host cells transformed with that expression system and expressing the gene conferring disease resistance to impart such resistance to the host cells.Type: GrantFiled: May 22, 1995Date of Patent: July 15, 1997Assignee: Cornell Research Foundation, Inc.Inventors: Steven D. Tanksley, Gregory B. Martin
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Patent number: 5633435Abstract: Genes encoding Class II EPSPS enzymes are disclosed. The genes are useful in producing transformed bacteria and plants which are tolerant to glyphosate herbicide. Class II EPSPS genes share little homology with known, Class I EPSPS genes, and do not hybridize to probes from Class I EPSPS's. The Class II EPSPS enzymes are characterized by being more kinetically efficient than Class I EPSPS's in the presence of glyphosate. Plants transformed with Class II EPSPS genes are also disclosed as well as a method for selectively controlling weeds in a planted transgenic crop field.Type: GrantFiled: September 13, 1994Date of Patent: May 27, 1997Assignee: Monsanto CompanyInventors: Gerard F. Barry, Ganesh M. Kishore, Stephen R. Padgette, William C. Stallings
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Patent number: 5608146Abstract: There are described DNA sequences, that contain the coding region of an oligosaccharide transporter, whose introduction in a plant genome modifies the formation and transfer of storage materials in transgenic plants, plasmids, bacteria and plants containing these DNA sequences, a process for the preparation and transformation of yeast strains, that makes possible the identification of the DNA sequences of the plant oligosaccharide transporter of the invention, as well as the use of DNA sequences of the invention.Type: GrantFiled: December 21, 1994Date of Patent: March 4, 1997Assignee: Institut Fur Genbiologische Forschung Berlin GmbHInventors: Wolf-Bernd Frommer, Jorg Riesmeier