Detecting Cancer Patents (Class 435/6.14)
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Patent number: 11634773Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.Type: GrantFiled: July 13, 2018Date of Patent: April 25, 2023Assignees: THE FRANCIS CRICK INSTITUTE LIMITED, UNIVERSITY COLLEGE LONDON, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Charles Swanton, Nicholas McGranahan, Rachel Rosenthal
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Patent number: 11623002Abstract: The invention features immunogenic compositions containing anaplastic lymphoma kinase (ALK) polypeptides and methods of use thereof. The immunogenic compositions and methods of the invention may be used to treat a disease associated with ALK in a subject, such as cancer (e.g., a solid tumor cancer or an ALK+ cancer).Type: GrantFiled: January 27, 2017Date of Patent: April 11, 2023Assignee: Elicio Therapeutics, Inc.Inventors: Adrienne Li, Jackson Eby, Peter C. Demuth
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Patent number: 11625139Abstract: Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.Type: GrantFiled: November 22, 2022Date of Patent: April 11, 2023Assignee: 23andMe, Inc.Inventors: John Michael Macpherson, Brian Thomas Naughton, Joanna Louise Mountain
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Patent number: 11619640Abstract: The method for generating an index for managing the analytical accuracy of a sample analyzer includes a step of acquiring a determination result related to whether a sample is positive or negative from a plurality of sample analyzers, and a step of generating an index based on a ratio of a sample determined to be positive or negative by the plurality of sample analyzers from a plurality of determination results obtained from the plurality of sample analyzers.Type: GrantFiled: March 28, 2019Date of Patent: April 4, 2023Assignee: SYSMEX CORPORATIONInventors: Mamoru Ashida, Motonari Daito, Fumiko Kino, Michiko Yoshimoto, Akane Seki, Kazuhiro Nakashima, Hideki Hirano
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Patent number: 11608537Abstract: The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting Adenovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers.Type: GrantFiled: July 2, 2020Date of Patent: March 21, 2023Assignee: GEN-PROBE PRODESSE, INC.Inventors: Emily Ziegler, Jessica Townsend
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Patent number: 11608520Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample.Type: GrantFiled: December 15, 2021Date of Patent: March 21, 2023Assignee: 10x Genomics, Inc.Inventors: Christina Galonska, Marco Mignardi
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Patent number: 11603566Abstract: The current disclosure relates to therapeutic treatments and diagnostic methods for esophageal cancer based on the expression level of biomarker miRNAs.Type: GrantFiled: August 4, 2017Date of Patent: March 14, 2023Assignee: Cancer Diagnostics Research InnovationInventors: Ajay Goel, Jinsei Miyoshi
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Patent number: 11597968Abstract: The invention relates to a method for analysing ribonucleic acid (RNA) interactions comprising: a) cross-linking base-paired nucleotides of at least one RNA molecule and/or at least one pair of RNA molecules using a tagged, reversible cross-linking agent (preferably tagged-psoralen) under ultraviolet irradiation; b) fragmenting the said cross-linked RNA molecule(s); c) using said tag to extract said cross-linked RNA fragment(s); d) ligating the said cross-linked RNA fragment(s) to produce cross-linked ligated RNA chimera(s); e) reversing the cross-linking of the said agent to the said RNA molecule(s); f) preparing a sequence library by sequencing the ligated RNA chimera molecule(s) or pair(s); and g) analysing the sequence library to determine RNA interactions. Also disclosed is a method of studying a subject by analysing RNA interactions and attributing them to a clinical picture, or a drug discovery method by attributing an efficacy score to the drug based upon determined RNA interactions.Type: GrantFiled: May 12, 2017Date of Patent: March 7, 2023Assignee: Agency for Science, Technology and ResearchInventors: Yue Wan, Jong Ghut Ashley Aw, Niranjan Nagarajan, Andreas Wilm, Miao Sun
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Patent number: 11591660Abstract: Methods and oligonucleotide reagents for diagnosing chikungunya virus and Zika virus infections are described. In particular, the invention relates to quantitative assays that can detect all lineages of chikungunya virus and Zika virus and distinguish chikungunya virus and Zika virus from each other as well as dengue virus and other arbovirus pathogens.Type: GrantFiled: January 14, 2017Date of Patent: February 28, 2023Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Benjamin A. Pinsky, Jesse Waggoner
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Patent number: 11579088Abstract: Systems and methods for measuring short wave infrared fluorescence and autofluorescent signals are disclosed. In some embodiments, for example, a method may include exposing a portion of tissue that does not include a fluorescent probe to an excitation source of the tissue, wherein at least a portion of the tissue has an autofluorescence spectrum which includes wavelengths greater than 900 nm, and imaging the tissue with a detector that is sensitive to electromagnetic radiation with wavelengths greater than or equal to 900 nm. In certain other embodiments, a system comprises a fluorescent probe including a fluorescent component attached to a carrier, an excitation source, and a detector that detects a tail portion of the fluorescence of the fluorescent component. Methods associated with such a system are also disclosed.Type: GrantFiled: March 10, 2017Date of Patent: February 14, 2023Assignees: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Moungi G. Bawendi, Oliver Thomas Bruns, Jessica Ann Carr, Klaus van Leyen, Yi Zheng, Marianne Aellen
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Patent number: 11578327Abstract: The present disclosure provides antisense oligonucleotides, compositions, and methods that target ATP7B exon 6 or a flanking intron, thereby modulating splicing of ATP7B pre-mRNA to increase the level of ATP7B mRNA molecules having exon 6, e.g., to provide a therapy for Wilson disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to an ATP7B target sequence in exon 6, a 5?-flanking intron, a 3?-flanking intron, or a combination of exon 6 and the 5?-flanking or 3?-flanking intron.Type: GrantFiled: February 14, 2019Date of Patent: February 14, 2023Assignee: Deep Genomics IncorporatedInventors: Daniele Merico, Erno Wienholds, Frank Schmitges, Matthew O'Hara
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Patent number: 11572593Abstract: The present invention relates to a method of selectively amplifying at least one nucleic acid sequence of at least one microorganism and/or virus in a sample of a subject, wherein k-mers 3 are applied that show a difference in frequency and/or context in the genome 2 of the at least one microorganism and/or virus compared to the genome of the subject 1.Type: GrantFiled: November 28, 2017Date of Patent: February 7, 2023Assignee: Siemens AktiengesellschaftInventors: Carsten Dietrich, Yiwei Huang, Mark Matzas, Andreas Emanuel Posch
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Patent number: 11573243Abstract: Provided is a temperature control system applied to an apparatus for analyzing a sample using a pipette nozzle and a reaction container, including a pipette tip temperature controller that heats a pipette tip which is fitted on the pipette nozzle and aspirates or discharges liquid and a reaction container temperature controller that heats the reaction container. The pipette tip temperature controller heats, in a concentrated manner, at least a distal end portion of the pipette tip of the pipette nozzle located at a predetermined heating position with hot air emitted from a heat source and is configured such that a distal end is capable of arriving at the reaction container by lowering the pipette nozzle from the heating position.Type: GrantFiled: March 2, 2018Date of Patent: February 7, 2023Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hiromi Fujii, Teiji Tanaka, Tatsuya Yamazaki, Tomoharu Nakagawa, Tetsuya Noda, Atsuo Iwashita, Yuuya Shouji
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Patent number: 11573235Abstract: A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods.Type: GrantFiled: March 21, 2013Date of Patent: February 7, 2023Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Antti E. Seppo, Fiona Ginty, Kevin B. Kenny, David Lavan Henderson, Michael J. Gerdes, Adriana Ines Larriera, Xiaofeng Liu, Alex D. Corwin, Stephen E. Zingelewicz, Thomas Ha, Natalia R. Jun, Ainura Kyshtoobayeva, Denise A. Hollman-Hewgley, Ying Li
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Patent number: 11566277Abstract: Methods of analyzing nucleic acids of a cell are provided.Type: GrantFiled: February 15, 2022Date of Patent: January 31, 2023Assignee: President and Fellows of Harvard CollegeInventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
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Patent number: 11560596Abstract: Disclosed is a method for expecting and diagnosing UQCRB-related disease, and more particularly, related to a method for diagnosing a UQCRB-related disease and a cholesterol biosynthesis related disease, as well as expecting risks of post-occurrence of the UQCRB-related disease and the cholesterol biosynthesis related disease, simply by measuring an expression level of miRNA, and a kit and a biomarker composition for the method.Type: GrantFiled: February 7, 2020Date of Patent: January 24, 2023Assignee: Industry-Academic Cooperation Foundation, Yonsei UniversityInventors: Ho Jeong Kwon, Jeong Eun Kim
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Patent number: 11549935Abstract: A method of exporting measurements of a nanopore sensor on a nanopore based sequencing chip is disclosed. An electrical characteristic associated with the nanopore sensor is measured. The electrical characteristic associated with the nanopore sensor is processed. A summary for the electrical characteristic and one or more previous electrical characteristics is determined. The summary for the electrical characteristic and the one or more previous electrical characteristics are exported. Determining the summary includes determining that the electrical characteristic and at least a portion of the one or more previous electrical characteristics correspond to a base call event at the nanopore sensor. The summary represents the electrical characteristic and the at least a portion of the one or more previous electrical characteristics.Type: GrantFiled: June 3, 2020Date of Patent: January 10, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Roger J. A. Chen, Santiago Fernandez-Gomez, Hui Tian
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Patent number: 11542561Abstract: Provided herein is a real-time PCR-based method of detecting, in a sample, an agent causing onychodystrophy, wherein the agent causing onychodystrophy belongs to a secondary clade member including one or more primary clade members. Also provided are compositions and kits that finds use in implementing the present method.Type: GrantFiled: February 20, 2020Date of Patent: January 3, 2023Assignee: BAKOTIC PATHOLOGY ASSOCIATES, LLCInventors: Idowu Akinsanmi, Lori Bennett, Liquan Yang, Marianna Agassandian, Rama Murthy Sakamuri, Erik Gustafson, Lilly Kong, Kiran Madanahally Divakar
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Patent number: 11524063Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.Type: GrantFiled: November 15, 2018Date of Patent: December 13, 2022Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, BAYLOR COLLEGE OF MEDICINEInventors: Sri Krishna, Marshall Posner, Andrew Sikora, Karen Anderson
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Patent number: 11519036Abstract: The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject.Type: GrantFiled: July 23, 2019Date of Patent: December 6, 2022Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Mikkel Noerholm, Johan Karl Olov Skog, Xandra O. Breakefield, Bob Carter
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Patent number: 11504021Abstract: A method for detecting tumor tissue boundaries or a tumor stromal cell distribution range, more specifically, a diagnostic or non-diagnostic method for determining the boundaries of a tumor tissue; the boundaries of the tumor tissue are determined by means of determining the boundaries of the tumor stromal cells in the tumor tissue. The present method can more accurately determine the boundaries of tumor tissue, which serves to more accurately instruct the treatment of tumors, especially with respect to surgical treatment.Type: GrantFiled: June 9, 2017Date of Patent: November 22, 2022Assignee: SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINEInventors: Jun Mi, Jiangmin Zhao, Yazhi Xing, Yongbin Wang, Jinliang Wu, Bocheng Wang
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Patent number: 11505620Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.Type: GrantFiled: May 14, 2019Date of Patent: November 22, 2022Assignee: Takeda Pharmaceutical Company LimitedInventors: Daniel J. Sexton, Malini Viswanathan
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Patent number: 11499150Abstract: Use of the surface presentation level of binders (e.g., antibodies, receptors) on cultured higher eukaryotic cells in vitro as a predictive indicator of developability characteristics, e.g., solubility, of the binders. Display libraries of higher eukaryotic cells, e.g., mammalian cells, adapted for use in screening surface-displayed binders for developability and affinity of target binding. High-throughput screening of display libraries with in-built selection for developability including binder solubility, capability to be formulated at high concentrations, low propensity for non-specific binding, and half-life. Enrichment of populations of binders for developability characteristics and/or other qualities such as target binding and affinity, by controlling cell surface presentation of binders from an inducible promoter operably linked to binder-encoding DNA.Type: GrantFiled: December 5, 2018Date of Patent: November 15, 2022Assignee: Iontas LimitedInventors: John McCafferty, Rajika Perera, Michael Richard Dyson, Kothai Parthiban, Johanna Liinamaria Syrjanen
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Patent number: 11492671Abstract: miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.Type: GrantFiled: April 10, 2019Date of Patent: November 8, 2022Assignees: ISTITUTI FISIOTERAPICI OSPITALIERI, ISTITUTO NAZIONALE TUMORI I.R.C.C.S. “FONDAZIONE G. PASCALE”, UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA”Inventors: Gennaro Ciliberto, Paolo Antonio Ascierto, Luigi Fattore, Gerardo Botti, Rita Mancini
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Patent number: 11492663Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.Type: GrantFiled: February 15, 2019Date of Patent: November 8, 2022Assignee: Takara Bio USA, Inc.Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
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Patent number: 11492650Abstract: Polypeptides that fold into biologies are stabilized by diselenide bonds between selenocysteine amino acids. Methods to produce such polypeptides in genomically recoded organisms (GRO) can be scaled up for industrial production. Since diselenides have the same geometric bond angles and torsions as disulfides, as well as very similar bond lengths, they can be substituted into polypeptides without disrupting the three dimensional structure of the polypeptides. Diselenides render the polypeptides resistant to reduction when they are exposed to blood serum or to reducing components of blood serum or to reducing components components within cells.Type: GrantFiled: August 30, 2017Date of Patent: November 8, 2022Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Daniel J. Mandell, Christopher John Gregg, Ross Thyer, Andrew D. Ellington, Peter Benjamin Stranges
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Patent number: 11486877Abstract: Disclosed is a measurement method for measuring a test substance contained in a biological sample based on a predetermined measurement principle, comprising acquiring a first measured value of the test substance using a first measurement reagent, and operating the first measured value to an arithmetic value when measured using a second measurement reagent different from the first measurement reagent, by using arithmetic information designed to make a first cut-off value for the measured value obtained using the first measurement reagent correspond to a second cut-off value for a measured value obtained using the second measurement reagent.Type: GrantFiled: April 6, 2018Date of Patent: November 1, 2022Assignee: SYSMEX CORPORATIONInventors: Mamoru Ashida, Motonari Daito, Tetsuro Morinaga
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Patent number: 11486007Abstract: Disclosed herein is a combination of genomic sequences whose methylation patterns have utility for the improved detection and differentiation between colorectal neoplasms. Further disclosed herein are methods, nucleic acids and kits for detecting or differentiating between colorectal neoplasms.Type: GrantFiled: June 3, 2015Date of Patent: November 1, 2022Assignees: Quest Diagnostics Investments Incorporated, CLINICAL GENOMICS PTY LTDInventors: Susanne Pedersen, Lawrence LaPointe, Rohan Baker, Amber C. Donahue, Yen-lin Peng, Frederic Waldman
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Patent number: 11471098Abstract: Systems and methods are provided for monitoring the effects of therapeutics on the brain. Brains of first and second sets of patients are imaged and a gene expression is measured at a first time to provide a first set of images and a first set of gene expression transcripts. A therapeutic is administered to the first set of patients after the first time. The brains of the patients are imaged and the gene expression of the patients is measured at a second time, after the therapeutic is administered, to provide a second set of images and a second set of gene expression transcripts. A change in the brain is determined for the patients from the sets of images. A set of changes in the gene expression that are correlated with the changes in the brain are determined from the change in the brain and the sets of gene expression transcripts.Type: GrantFiled: January 22, 2020Date of Patent: October 18, 2022Assignee: THE CLEVELAND CLINIC FOUNDATIONInventor: Amit Anand
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Patent number: 11468967Abstract: Systems and methods for computer-aided vaccine design may comprise performing one or more molecular dynamics simulations of a protein assembly having at least one epitope, determining a fluctuation measurement for the at least one epitope using the one or more molecular dynamics simulations, and predicting the immunogenicity of the protein assembly in response to the fluctuation measurement are disclosed.Type: GrantFiled: March 5, 2012Date of Patent: October 11, 2022Assignee: INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORP.Inventor: Peter J. Ortoleva
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Patent number: 11466328Abstract: The present invention provides methods and compositions that are useful for assessing gene expression for tumor immune response profile of a sample. In particular, a target-specific primer panel is provided that allows for selective amplification of immune response target sequences in a sample. In one aspect, the invention relates to target-specific primers useful for selective amplification of one or more target sequences associated with immune response. In some aspects, amplified target sequences obtained using the disclosed methods, and compositions can be used in various processes including nucleic acid sequencing and used to detect the presence of genetic variants and/or expression levels of one or more targeted sequences associated with immune response.Type: GrantFiled: September 22, 2017Date of Patent: October 11, 2022Assignee: Life Technologies CorporationInventors: Ann Mongan, Alex Atkins
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Patent number: 11466323Abstract: A digital droplet PCR method of analyzing the methylation status of methylation sites of a double-stranded DNA molecule which comprises at least two methylation sites per single strand of the double-stranded DNA molecule is disclosed.Type: GrantFiled: July 13, 2018Date of Patent: October 11, 2022Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.Inventors: Yuval Dor, Ruth Shemer, Benjamin Glaser, Judith Magenheim
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Patent number: 11459605Abstract: The present invention relates to a method for the in vitro diagnosis or prognosis of prostate cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic acid sequence, the use of said nucleic acid sequences, once isolated, as one or more molecular marker(s) and a kit comprising at least one specific binding partner of at least one of the expression products of the HERV nucleic acid sequences.Type: GrantFiled: December 18, 2012Date of Patent: October 4, 2022Assignees: BIOMERIEUX, HOSPICES CIVILS DE LYONInventors: François Mallet, Nathalie Mugnier, Philippe Perot
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Patent number: 11456055Abstract: Provided are methods, systems, and computer products for genotyping polyploid organisms, as well as diploid organisms. The provided methods use an allele-intensity model to generate cluster definitions. The allele-intensity model relates allele counts of different genotypes to signal intensities generated by the genotyping platform. The model also includes a capability to update cluster positions obtained from a maximum likelihood model using a Bayesian method.Type: GrantFiled: June 2, 2017Date of Patent: September 27, 2022Assignee: Illumina, Inc.Inventor: Ryan Kelley
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Patent number: 11447531Abstract: A peptide comprised of either a binary or a tertiary peptide, the peptide contains at least 4 amino acids and up to a maximum of 16 amino acids, comprised of 2 or 3 different regions, wherein the binary peptides have 2 different regions and the tertiary peptides have 3 different regions; wherein, the peptide can be cleaved by both an animal gut protease and an insect or nematode gut protease.Type: GrantFiled: October 6, 2017Date of Patent: September 20, 2022Assignee: Vestaron CorporationInventors: Alvar R. Carlson, Alexandra M. Haase, Robert M. Kennedy
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Patent number: 11420174Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.Type: GrantFiled: December 16, 2016Date of Patent: August 23, 2022Assignee: Safeguard Biosystems Holdings Ltd.Inventors: Holger Klapproth, Sonja Bednar
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Patent number: 11423547Abstract: Systems and methods are disclosed for receiving one or more electronic slide images associated with a tissue specimen, the tissue specimen being associated with a patient and/or medical case, partitioning a first slide image of the one or more electronic slide images into a plurality of tiles, detecting a plurality of tissue regions of the first slide image and/or plurality of tiles to generate a tissue mask, determining whether any of the plurality of tiles corresponds to non-tissue, removing any of the plurality of tiles that are determined to be non-tissue, determining a prediction, using a machine learning prediction model, for at least one label for the one or more electronic slide images, the machine learning prediction model having been generated by processing a plurality of training images, and outputting the prediction of the trained machine learning prediction model.Type: GrantFiled: September 21, 2021Date of Patent: August 23, 2022Assignee: Paige.AI, Inc.Inventors: Brandon Rothrock, Christopher Kanan, Julian Viret, Thomas Fuchs, Leo Grady
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Patent number: 11413328Abstract: The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid refractory asthma, status asthmaticus, pneumonia, bronchiectasis, COPD, sarcoidosis, and lung cancer based on reducing airway hyper responsiveness, increasing pulmonary compliance, reducing lung inflammation, reducing inflammatory cell count in bronchoalveolar fluid and reducing cytokine production by administration of a mammalian ?- and/or ?-defensin.Type: GrantFiled: December 13, 2017Date of Patent: August 16, 2022Assignee: NOVOZYMES A/SInventors: Peter Nordkild, Søren Kjærulff
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Patent number: 11408039Abstract: Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL).Type: GrantFiled: September 30, 2020Date of Patent: August 9, 2022Assignee: The Government of The United States, as represented by The Secretary of The ArmyInventor: Jane Shen-Gunther
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Patent number: 11401559Abstract: Methods and kits are provided for screening a patient for bladder cancer. Embodiments include those involving centromeric probes to chromosomes 3, 7, and 10 and a locus-specific probe to 5p15.Type: GrantFiled: August 6, 2019Date of Patent: August 2, 2022Assignee: LEICA BIOSYSTEMS NEWCASTLE LTDInventors: Saskia Schoenmakers, Harry Schrickx, Herman Volkers
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Patent number: 11398303Abstract: Described here are systems and methods for generating and analyzing co-expression signature data from scalar or multi-dimensional data fields contained in or otherwise derived from imaging data acquired with a medical imaging system. A similarity metric, such as an angular similarity metric, is computed between the data field components contained in pairs of voxels in the data field data. The data fields can be scalar fields, vector fields, tensor fields, or other higher-dimensional data fields. A probability distribution of these similarity metrics can be generated and used as co-expression signature data that indicate pairwise disparities in the data field data.Type: GrantFiled: August 27, 2020Date of Patent: July 26, 2022Assignee: Northwestern UniversityInventors: Mohammed S. M. Elbaz, Michael Markl
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Patent number: 11389799Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.Type: GrantFiled: January 17, 2020Date of Patent: July 19, 2022Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Mark A. Burns, Alyse D. Krausz, Sarah Elizabeth Mena, Martin Patrick De Beer, Kevin R. Ward, Frederick Korley
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Patent number: 11382976Abstract: A method comprising: providing aqueous antibodies; cationizing the aqueous antibodies by the addition of stoichiometric amounts of an excess of a positively-charged crosslinker in the presence of a coupling reagent; titrating the cationized antibodies with a counter anionic polymer until the antibody cation/anion pair solution becomes negative by zeta potential measurement, to create at least one antibody cation/anion pair in aqueous solution. The antibodies are one of anti-hemoglobin antibodies, anti-horse spleen ferritin IgG antibodies, or blood-typing IgM Anti-A antibodies, single-chain antibodies from camelids, monoclonal Anti-Flag antibodies, monoclonal Anti-HRP2 to Plasmodium falciparum, polyclonal Anti-neuropeptide Y, and polyclonal Anti-human troponin. The antibody cation/anion pair solution may be lyophilized to remove all of the water, forming a lyophilized solid, and the lyophilized solid may be heated to generate an antibody ionic liquid.Type: GrantFiled: September 30, 2019Date of Patent: July 12, 2022Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Joseph M Slocik, Rajesh R. Naik, Patrick B Dennis
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Patent number: 11380420Abstract: A system is described for constructing a biological simulation using inputs from a knowledge base data structure and one or more templates. The knowledge base data structure comprises a set of entries representing distinct molecules and chemical reactions specific within the cell. Each template defines a sub-model program specification and a set of sub-model parameters to further characterize the sub-model specification. A graphical user interface is presented on a display for a user to view and select a templates and to assign information from the knowledge base to the selected template. From the graphical user interface, the user selects multiple templates to be included in the simulation and information from the knowledge base generally describing the cell. Based on the information selected from the graphical user interface, a compiler generates a simulation configuration data file comprising computer code capable of being executed by a simulation engine.Type: GrantFiled: May 7, 2018Date of Patent: July 5, 2022Assignee: X Development LLCInventors: Frank Russo, Jason Thompson, Nicholas Casavant, Yu Tanouchi
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Patent number: 11369673Abstract: Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.Type: GrantFiled: September 14, 2016Date of Patent: June 28, 2022Assignee: Etubics CorporationInventors: Joseph P. Balint, Frank R. Jones, Richard B. Gayle
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Patent number: 11371882Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.Type: GrantFiled: August 26, 2020Date of Patent: June 28, 2022Assignee: NUEON INC.Inventors: Robert Messerschmidt, Howland D.T. Jones
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Patent number: 11366301Abstract: A method and an apparatus for imaging a sample (14). In the method, a first excitation radiation (5) is focused into a volume of the sample (14) and a caused first detection radiation (15) is captured and evaluated in respect of a form of its wavefront. A second excitation radiation (11) is manipulated on the basis of the evaluation results in order to correct the ascertained deviations of the wavefront. A region (20) to be imaged of the sample (14) is scanned by means of the second excitation radiation (11) and a second detection radiation (16) is captured as image data. The second excitation radiation (11) is directed in the form of at least two partial beams (11T) into the sample volume, into a respective spot (22) illuminated by the partial beam (11T) and the second detection radiations (16) respectively caused by the partial beams (11T) are captured separately.Type: GrantFiled: December 1, 2020Date of Patent: June 21, 2022Assignee: Carl Zeiss Microscopy GmbHInventors: Daniel Schwedt, Tiemo Anhut
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Patent number: 11359236Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, and systems for sequencing a nucleic acid using one or more labels and signal amplitude to distinguish bases.Type: GrantFiled: January 27, 2020Date of Patent: June 14, 2022Assignee: IBIS BIOSCIENCES, INC.Inventor: Mark W. Eshoo
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Patent number: 11339444Abstract: A method for detecting genes sensitive to low-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to low-level ionizing radiation and related to suppressing thymic cancer, discovered in a carcinogenic entity and verified in a normal entity are detected by subjecting a cancerous AKR/J mouse and a normal ICR mouse to low-level radiation. Thymus is collected therefrom, immunogenic and apoptotic genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, a gene having a specific reaction to radiation can be accurately detected by preventing the interference of confounding variables.Type: GrantFiled: November 16, 2018Date of Patent: May 24, 2022Assignee: KOREA HYDRO & NUCLEAR POWER CO., LTDInventors: Hee Sun Kim, Seung Jin Choi, Moo Hyun Choi, Jin Jong Bong, Seok Cheol Shin
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Patent number: 11340221Abstract: Disclosed are a protein molecular marker Dkk-3 protein associated with age-related muscle atrophy and the use thereof in the diagnosis of age-related muscle atrophy. The expression level of the Dkk-3 protein in amyotrophic cells is significantly higher than that in normal myocytes or tissues, and thus the Dkk-3 protein can be used as an effective marker for the detection of age-related muscle atrophy.Type: GrantFiled: April 28, 2016Date of Patent: May 24, 2022Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Ping Hu, Jie Yin