Involving A Nucleic Acid Encoding A Protein Related To The Nervous System, (e.g., Nerve Related Factors, Brain-derived Cytokines, Nerve Cell Biomarker, Etc.) Patents (Class 435/6.16)
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Patent number: 11499188Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.Type: GrantFiled: October 21, 2019Date of Patent: November 15, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11499978Abstract: The present invention provides a method of measuring the quality of therapeutic cells through real-time glutathione monitoring.Type: GrantFiled: November 28, 2018Date of Patent: November 15, 2022Assignee: CELL2IN, INC.Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Gwang Mo Yang, Ji Woong Shin, Hye Won Kang, Yong Hwan Kim, Myung Jin Kim
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Patent number: 11492664Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.Type: GrantFiled: August 1, 2018Date of Patent: November 8, 2022Assignee: California Institute of TechnologyInventors: Aditya Rajagopal, Emil P. Kartalov
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Patent number: 11492414Abstract: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to ERG, and more specifically, to an epitope formed by amino acids 42-66 of ERG3 are disclosed. The monoclonal antibodies can be non-human antibodies (e.g., rabbit or mouse) or humanized monoclonal antibodies having the CDR regions derived from those non-human antibodies. In other embodiments, the monoclonal antibodies are chimeric, having the light and heavy chain variable regions of a non-human ERG antibody. Methods of using the antibodies to detect ERG, or fusion proteins comprising all or part of an ERG polypeptide, such as an ERG polypeptide encoded by a TMPRSS2/ERG, SLC45A3/ERG, or NDRG1/ERG fusion transcript, are also provided, including methods of detecting ERG or ERG fusion events in a clinical setting.Type: GrantFiled: February 15, 2019Date of Patent: November 8, 2022Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Shiv Srivastava, Shyh-Han Tan, Albert Dobi
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Patent number: 11486873Abstract: Disclosed herein are methods and compositions for determining an improved estimate of the fractional abundance of target analytes (e.g., specific polynucleotide sequences) in a sample using a nanopore sensor having one or more nanopores-, e.g., by correcting errors inherent to identifying and correlating electrical signals to amounts of a target analyte or reference analyte in a sample.Type: GrantFiled: April 22, 2019Date of Patent: November 1, 2022Assignee: Ontera Inc.Inventors: Yanan Zhao, William McKenna, William B. Dunbar
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Patent number: 11485992Abstract: Methods of culturing and detecting a biomarker which may be associated with autoimmune diseases, in particular inflammatory bowel disease and Crohn's disease; also a screening method for substances suitable for the treatment of inflammatory bowel disease including Crohn's disease; the method including culturing a biomarker in a culture media which includes a culture broth, OADC, PANTA and Mycobactin J.Type: GrantFiled: December 14, 2016Date of Patent: November 1, 2022Inventors: John Milford Aitken, Kevin Andrew Taylor
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Patent number: 11487720Abstract: Systems, methods, and non-transitory computer readable media may be configured to access first database and a second database. The first database may be structured for a first data type, and may include a first data of the first data type. The second database may be structured for a second data type different from the first datatype, and may include a second data of the second data type. The second data may be associated with the first data. A first information request relating to the first data and a second information request relating to the second data may be received. A first response to the first information request may be determined based on the second data. A second response to the second information request may be determined based on the first data. An interface, through which the first response or the second response is accessible, may be provided.Type: GrantFiled: September 21, 2018Date of Patent: November 1, 2022Assignee: Palantir Technologies Inc.Inventors: Peter Wilczynski, Sharon Hao, Will Deuschle, Ernest Zeidman
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Patent number: 11485994Abstract: Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological sample includes creating a mixture comprising encapsulated microbubbles mixed with a biological sample and adding activation energy to the mixture to cause at least some of the microbubbles to oscillate or burst and thereby process the sample, including effecting cell lysis, shearing DNA, and/or performing tissue dispersion.Type: GrantFiled: May 25, 2018Date of Patent: November 1, 2022Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: William Perry Janzen, Samantha Gail Pattenden, Chatura Nadisha Jayakody, Jason Eric Streeter, Paul Alexander Dayton, Cameron Champion Wood, Siddharth Kaup Shenoy
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Patent number: 11478555Abstract: The present invention relates to chimeric antibody receptors with anti-cotinine antibodies linked, and use thereof. A T cell presenting the chimeric antibody receptor on the surface secretes interferon gamma specifically for a target molecule of a cotinine-conjugated binding molecule that is added together therewith and induces cell death of the cell expressing the target molecule by the T cell. On the contrary, by administering a cytotoxic agent conjugated with cotinine, cell death of the chimeric antigen receptor T cell is induced. Therefore, if necessary, a cytotoxic agent conjugated with cotinine can be administered to remove the chimeric antigen receptor T cells that have been already administered, thereby suppressing immune side effects due to hyperactivity of T cells. Thus, the chimeric antigen receptor to which the anti-cotinine antibody is linked can be effectively and safely used for the treatment of cancer.Type: GrantFiled: August 17, 2016Date of Patent: October 25, 2022Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Kyungho Choi, Hyung-Bae Park, Ji Eun Lee, Yumi Oh, Ki-Hyun Kim, Soohyun Kim, Hyori Kim, Junho Chung
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Patent number: 11479826Abstract: Provided are detection means and method specific for the genus Cronobacter (E. sakazakii) which are sensitive by using a target molecule which is multiple existent in Cronobacter cells.Type: GrantFiled: November 20, 2014Date of Patent: October 25, 2022Assignee: Biotecon Diagnostics GmbHInventors: Cordt Grönewald, Kornelia Berghof-Jäger
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Patent number: 11473079Abstract: The present invention relates to a method for prenatal diagnosis using digital PCR, and more particularly to a method for providing information for diagnosis of chromosomal aneuploidy in a fetus, comprising: (a) extracting DNAs from pregnant woman's blood; (b) classifying the DNAs according to size to obtain DNAs having a size of 1,000 bp or less; (c) performing digital PCR using the obtained DNAs of step (b), for a control gene located on a chromosome not associated with chromosomal aneuploidy and a target gene located on a chromosome associated with chromosomal aneuploidy; (d) calculating a ratio of a quantitative digital PCR value of the target gene to a quantitative digital PCR value of the control gene; and (e) determining that when the ratio calculated in step (d) is 0.70-1.14, a chromosome number of the fetus is normal.Type: GrantFiled: October 28, 2016Date of Patent: October 18, 2022Assignee: BIOCORE CO., LTD.Inventors: Seung Yong Hwang, Moon Ju Oh, Seung Jun Kim, Jong Pil Youn, Ji Hoon Kim, Seung Yong Lee, Jeong Jin Ahn, Joon Soo Park, Hyo Jung Choi
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Patent number: 11459617Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRI) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.Type: GrantFiled: April 28, 2017Date of Patent: October 4, 2022Assignees: Board of Regents, The University of Texas System, Yale UniversityInventors: William Fraser Symmans, Bruno Sinn, Christos Hatzis, Chunxiao Fu, Rosanna Lau
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Patent number: 11453722Abstract: The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to tenascin C (TnC), and to methods of producing these molecules and to methods of using the same.Type: GrantFiled: September 26, 2019Date of Patent: September 27, 2022Assignee: Hoffmann La-Roche Inc.Inventors: Maria Amann, Sandra Grau-Richards, Christian Klein, Mudita Pincha, Pablo Umaña
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Patent number: 11447540Abstract: Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.Type: GrantFiled: October 24, 2018Date of Patent: September 20, 2022Assignee: H. LUNDBECK A/SInventors: Gary Lesnicki, Patricia Dianne McNeill, Franz Hartner, Mark Young
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Patent number: 11441180Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.Type: GrantFiled: November 6, 2020Date of Patent: September 13, 2022Assignee: Fred Hutchinson Cancer CenterInventor: Jason H. Bielas
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Patent number: 11442057Abstract: The present invention relates to a method for screening an anticancer agent which inhibits the binding of AIMP2-DX2 and HSP70. In addition, the pharmaceutical composition for preventing or treating cancer comprising, as an active ingredient, an anticancer agent screened according to the method of the present invention inhibits the expression of HSP70 or inhibits the binding of HSP70 and AIMP2-DX2, thereby lowering the level of AIMP2-DX2 protein, and can effectively prevent the progression of cancer. As such, the pharmaceutical composition can be useful for developing a cancer treating agent.Type: GrantFiled: September 7, 2018Date of Patent: September 13, 2022Assignee: MEDICINAL BIOCONVERGENCE RESEARCH CENTERInventors: Sunghoon Kim, Dae Gyu Kim, Semi Lim
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Patent number: 11442067Abstract: The invention relates to peptide mass fingerprinting technique for the proteins such as Human insulin and insulin analogs. The insulin analogues can vary at least by one amino acid, which is elusive to distinguish by currently available analytical methods. The invention further allows sequence confirmation of the peptide wherein the run time of the method is forty minutes. This method could be applied for molecules up to 50 kDa.Type: GrantFiled: July 20, 2018Date of Patent: September 13, 2022Inventors: Phanichand Kodali, Krishnappa Mane, Srivatsa Koduru, Ashutosh Sudhir Naik, Laxmi Adhikary
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Patent number: 11434480Abstract: The present invention relates to a composition for viral RNA extraction and a viral RNA extraction method using the same, wherein various contaminants (e.g., fungi, bacteria, pollens, etc.) can be effectively removed from samples and thus the diagnosis of sample-derived viruses can be attained more sensitively, and more cheap reagents compared with existing compositions for RNA extraction are used and thus the scales of diagnosis tests of disease-mediated viruses and various monitoring programs can be further enlarged, thereby contributing to public health.Type: GrantFiled: May 25, 2018Date of Patent: September 6, 2022Assignee: Industry Foundation of Chonnam National UniversityInventors: Ki Beom Park, Yong Hun Jo, Yeon Soo Han
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Patent number: 11434474Abstract: The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. Also encompassed by the present disclosure are engineered cells with improved production capacity and improved product quality, methods for engineering such cells, and preparations and mixtures comprising the products from such cells.Type: GrantFiled: March 13, 2020Date of Patent: September 6, 2022Assignee: LONZA LTDInventors: James Budge, Christopher Mark Smales, Tanya Jeane Knight, Robert Young
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Patent number: 11434534Abstract: In an aspect, a method includes obtaining patient data for a patient, the patient data including one or more molecular biomarkers specific to the patient, standardizing and curating the patient data, classifying the standardized and curated patient data including classifying the one or more molecular biomarkers by one or more of its functional effects, using the one or more functional effects for the one or more molecular biomarkers to identify a combination of available therapeutic options by targeting biomarkers with relevant functional effects based on the patient data, applying a learning method to optimize results for presentation to a user, and presenting optimized results to the user.Type: GrantFiled: September 8, 2017Date of Patent: September 6, 2022Assignee: CureMatch, Inc.Inventors: Razelle Kurzrock, Igor Flint Tsigelny, Amélie Clémence Boichard, Sergey Kozhenkov, Kevin Toivo Bush, Timothy Viet Pham, Stephane Richard
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Patent number: 11434525Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.Type: GrantFiled: August 6, 2021Date of Patent: September 6, 2022Assignee: SINGULAR GENOMICS SYSTEMS, INC.Inventor: Eli N. Glezer
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Patent number: 11427820Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.Type: GrantFiled: September 26, 2019Date of Patent: August 30, 2022Assignees: BioMarin Technologies B.V., Academisch Ziekenbuls LeidenInventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
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Patent number: 11421217Abstract: Provided herein are compositions and methods of use thereof for collection, preservation and/or extraction of biologicals from a subject. For example, a solution that enables collection, preservation, and extraction of nucleic acids in a single step, and methods of using such solution are provided. In some embodiments, the compositions, kits, and methods are useful for the collection and analysis of samples from patients that have or are suspected of having SARS-CoV-2 virus that can cause Covid-19.Type: GrantFiled: April 7, 2021Date of Patent: August 23, 2022Inventors: Vincent T. Bicocca, Trevor Gilpin Levin
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Patent number: 11407978Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.Type: GrantFiled: August 18, 2011Date of Patent: August 9, 2022Assignee: Albert-Ludwigs-Universität FreiburgInventors: V. Prasad Shastri, Aurelien Forget
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Patent number: 11400145Abstract: The present invention relates generally to a population of stem cells (e.g., iPSCs or HSCs) that comprise nucleic acids encoding a T cell receptor and a chimeric antigen receptor directed to multiple distinct antigenic determinants, for example two distinct tumour antigenic determinants. The present invention is also directed to a population of T cells that co-express a T cell receptor and a chimeric antigen receptor directed to multiple distinct antigenic determinants, such as two distinct tumour antigenic determinants. The cells of the present invention can be derived from chosen donors whose HLA type is compatible with significant sectors of the populations, and are useful in a wide variety of applications, in particular in the context of the therapeutic treatment of neoplastic conditions.Type: GrantFiled: November 23, 2016Date of Patent: August 2, 2022Assignee: CARTHERICS PTY. LTD.Inventors: Richard Boyd, Alan Trounson, Hiroshi Kawamoto, Peter John Hudson, Runzhe Shu
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Patent number: 11404293Abstract: A cooling unit for cooling a substrate includes a plate having a fluid channel formed therein and a fluid supply member that supplies a fluid into the fluid channel. The fluid channel includes a plurality of first fluid channels, each of which is connected with the fluid supply member at one end thereof and a second fluid channel that is connected with opposite ends of the plurality of first fluid channels and that discharges the fluid. A buffer space that connects the opposite ends of the plurality of first fluid channels and one end of the second fluid channel is formed inside the plate.Type: GrantFiled: July 16, 2020Date of Patent: August 2, 2022Assignee: SEMES CO., LTD.Inventor: Jaeoh Bang
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Patent number: 11401325Abstract: Provided are novel human-derived anti-huntingtin (HTT) antibodies and biotechnological derivatives thereof, preferably capable of binding mutated and/or aggregated HTT species and or fragments thereof, as well as methods related thereto. The human-derived anti-HTT antibodies and biotechnological derivatives can be used in pharmaceutical and diagnostic compositions for HTT targeted immunotherapy of Huntington Disease and diagnosis thereof.Type: GrantFiled: February 7, 2020Date of Patent: August 2, 2022Assignee: Neurimmune Holding AGInventors: Marcel Maier, Jan Grimm
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Patent number: 11398293Abstract: A method for determining the presence of a copy number imbalance in genomic DNA of a test sample is provided. The method can separately measure hybridization of a single test sample to a first hybridization array and hybridization of a plurality of reference samples to a plurality of other, respective test arrays. A determination of copy number can be based on the best fit reference array, relative to the test array. The best fit can be determined based on the closest or most similar signal-to-noise ratio of the measured signals.Type: GrantFiled: November 7, 2019Date of Patent: July 26, 2022Assignee: BLUEGNOME LIMITEDInventors: Andrew Craig, Anthony Brown, Nicholas Haan
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Patent number: 11371039Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.Type: GrantFiled: September 14, 2020Date of Patent: June 28, 2022Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Takashi Nakai
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Patent number: 11365253Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.Type: GrantFiled: June 8, 2018Date of Patent: June 21, 2022Assignees: Pfizer Inc., Boston Medical Center CorporationInventors: Stephen Berasi, Janet Elizabeth Buhlmann, Eric M. Bennett, Nathan Higginson-Scott, Huilan Gao, Zong Sean Juo, Stefano V. Gulla, Christine Huard, Sreekumar R. Kodangattil, Jian Li, Weining Lu, Xueping Fan, David J. Salant
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Patent number: 11369007Abstract: The present invention relates to methods and systems that result in high quality, reproducible, thermal melt analysis on a microfluidic platform. The present invention relates to methods and systems using thermal systems including heat spreading devices, including interconnection methods and materials developed to connect heat spreaders to microfluidic devices. The present invention also relates to methods and systems for controlling, measuring, and calibrating the thermal systems of the present invention.Type: GrantFiled: January 23, 2017Date of Patent: June 21, 2022Assignee: Canon U.S.A., Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson
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Patent number: 11359194Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.Type: GrantFiled: September 14, 2020Date of Patent: June 14, 2022Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Takashi Nakai
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Patent number: 11352619Abstract: A method for synthesizing a target double stranded (ds) polynucleotide by providing an oligonucleotide library within an array device that has a diversity of oligonucleotide library members, each of which has a different nucleotide sequence and is contained in a separate library containment in an aqueous solution. The library includes single stranded oligonucleotides and double stranded oligonucleotides with at least one overhang and covers at least 10,000 pairs of matching oligonucleotides. In a first step, transferring at least a first pair of matching oligonucleotides transferred from the library into a first reaction containment using a liquid handler and the matching oligonucleotides are assembled, thereby obtaining a first reaction product comprising at least one overhang.Type: GrantFiled: October 15, 2018Date of Patent: June 7, 2022Assignee: RIBBON BIOLABS GMBHInventors: Harold Paul Vladar, Rodrigo Aparecido Fernandes Redondo
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Patent number: 11339441Abstract: The present invention relates to high-throughput methods comprising direct infusion electrospray ionization mass spectrometry (ESI-MS), multistep tandem mass spectrometry (MSn), consecutive reaction monitoring (CRM), ion mobility spectrometry mass spectrometry (IMS-MS), high-resolution MS, and IMS-MS, for genome-wide (whole cell or tissue) profiling of DNA and RNA nucleotides/nucleosides having a wide variety of variant structural modifications. In particular, these methods are contemplated for providing a specific profile of variant DNA and/or RNA chemically modified nucleic acids (i.e. structures) associated with specific medical conditions. Medical conditions may include, but are not limited to: cancer; including prostate, lung, uterus, larynx, ovary, breast, kidney, and many other types of cancers; specific stages of cancer; bacterial infections; viral infections; genetic and metabolic disorders; and any condition involving changes in DNA and/or RNA structural modifications.Type: GrantFiled: May 12, 2016Date of Patent: May 24, 2022Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Rebecca Rose, Daniele Fabris
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Patent number: 11338028Abstract: Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen are disclosed. Methods of treating a subject with a LEMD1-expressing tumor and methods of preventing a LEMD1-expressing tumor are disclosed. Mutated consensus LEMD1 antigen is disclosed.Type: GrantFiled: December 13, 2018Date of Patent: May 24, 2022Assignee: Inovio Pharmaceuticals, Inc.Inventors: Jian Yan, Anna Slager, Bradley Garman, Neil Cooch
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Patent number: 11339222Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, and ovarian cancer.Type: GrantFiled: June 2, 2017Date of Patent: May 24, 2022Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Steven Greenberg, Stefano Vincenzo Gulla, Kenneth Evan Thompson
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Patent number: 11331411Abstract: The present invention relates to the field of resorbing biodegradable medical and cosmetic compositions.Type: GrantFiled: May 30, 2018Date of Patent: May 17, 2022Assignee: AQPHA IP B.V.Inventors: Jeffrey Markgregorius Maria Stouthamer, Mónica Eunice dos Santos Rocha, Henderikus Supèr, Alexius Josephus Lankhorst
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Patent number: 11331388Abstract: Methods of treating fibrotic diseases and disorders including Systemic sclerosis (SSc) are provided. Methods include, for example, administering to a subject an effective amount of an antagonist/inhibitor of PTP4A1 protein expression or activity to treat a fibrotic disease or disorder such as SSc, or an associated pathology such as organ or skin fibrosis.Type: GrantFiled: September 6, 2016Date of Patent: May 17, 2022Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGYInventors: Nunzio Bottini, Cristiano Sacchetti, Stephanie M. Stanford
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Patent number: 11331365Abstract: Provided are a multispecific protein drug and a library thereof, a preparing method therefor and an application thereof. Specifically, a protein drug library is provided and comprises C different protein drug monomers, wherein the protein drug monomer comprises a protein drug component part and a nucleic acid component part connected with the protein drug component part, and the nucleic acid component part of one protein drug monomer establishes a double-stranded paired structure with a nucleic acid component part of at least one different protein drug monomer by means of complementation, thereby constituting a protein drug polymer, wherein C is a positive integer greater than or equal to 2.Type: GrantFiled: March 22, 2018Date of Patent: May 17, 2022Assignee: Assembly Medicine, LLCInventors: James Jeiwen Chou, Liqiang Pan
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Patent number: 11317848Abstract: The application generally relates to olfaction as a biomarker, more particularly as a prognostic biomarker or biological predictor, of neurosensory disease or disorder and/or of neurocognitive disease or disorder, in subjects whose nervous system has been infected by an infectious agent, such as by a neurotropic virus, bacterium, protozoan parasite, fungus or prion, more particularly by a neurotropic virus.Type: GrantFiled: May 19, 2017Date of Patent: May 3, 2022Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Françoise Lazarini-Serandour, Pierre-Marie Lledo, Natacha Teissier, Sarah Levivien
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Patent number: 11318134Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.Type: GrantFiled: January 8, 2019Date of Patent: May 3, 2022Assignee: Recurium IP Holdings, LLCInventors: Joseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker, Rakesh Kumar Sit, Ahmed Abdi Samatar
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Patent number: 11307164Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid, and a membrane comprising a test line for determining whether the fluid comprises a target analyte. The device includes an actuator connected to a moving element comprising a shaft or a wheel. A first magnet is connected to the backing of the membrane. Second and third magnets are connected to the moving element. The actuator moves the moving element between first and second positions. In the first position, the opposite poles of the first and second magnets attract each other and maintain a gap between the membrane and the conjugate pad separate. In the second position, the similar poles of the first and third magnets repel each other and close the gap between membrane and the conjugate pad, allowing the fluid to flow from the conjugate pad into the membrane and the test line.Type: GrantFiled: May 27, 2021Date of Patent: April 19, 2022Assignee: 2Pi-Sigma Corp.Inventor: Mehdi Hatamian
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Patent number: 11308387Abstract: A circuit implementing a spiking neural network that includes a learning component that can learn from temporal correlations in the spikes regardless of correlations in the rates. In some embodiments, the learning component comprises a rate-discounting component. In some embodiments, the learning rule computes a rate-normalized covariance (normcov) matrix, detects clusters in this matrix, and sets the synaptic weights according to these clusters. In some embodiments, a synapse with a long-term plasticity rule has an efficacy that is composed by a weight and a fatiguing component. In some embodiments, A Hebbian plasticity component modifies the weight component and a short-term fatigue plasticity component modifies the fatiguing component. The fatigue component increases with increases in the presynaptic spike rate. In some embodiments, the fatigue component increases are implemented in a spike-based manner.Type: GrantFiled: May 9, 2017Date of Patent: April 19, 2022Assignee: Samsung Electronics Co., Ltd.Inventors: Wabe W. Koelmans, Timoleon Moraitis, Abu Sebastian, Tomas Tuma
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Patent number: 11300640Abstract: The present invention relates to compositions and methods using protein reporters as imaging agents in 129Xe NMR and MRI applications. It is described that bla and MBP are genetically-encoded proteins that induce a detectable chemical shift during 129Xe NMR, allowing for use as protein reporters in research and clinical applications.Type: GrantFiled: March 13, 2018Date of Patent: April 12, 2022Assignee: The Trustees of the University of PennsylvaniaInventors: Ivan J. Dmochowski, Yanfei Wang, Benjamin W. Roose, Serge Zemerov, Zhuangyu Zhao
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Patent number: 11293049Abstract: Disclosed is a method for isolating, amplifying, and sequencing infectious agents' nucleic acids from an acellular fraction of a biological fluid using detergents and nucleic acids-digesting enzymes. Also disclosed is a kit-of-parts including detergents and nucleic acids-digesting enzymes for the implementation of the methods described.Type: GrantFiled: January 6, 2017Date of Patent: April 5, 2022Assignee: PATHOQUESTInventor: Éric Cabannes
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Patent number: 11268112Abstract: Provided herein are recombinant fungal or bacterial cells comprising a heterologous L-lactate dehydrogenase, and processes of preparing L-lactic acid employing such cells.Type: GrantFiled: April 11, 2019Date of Patent: March 8, 2022Assignee: Lygos, Inc.Inventors: Andrew Jonathan Conley, Mario Ouellet, Jeffrey A. Dietrich
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Patent number: 11259724Abstract: In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.Type: GrantFiled: March 12, 2015Date of Patent: March 1, 2022Inventors: Jeff T. Suri, Robert Boock
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Patent number: 11261484Abstract: A biomolecule analysis kit includes a reaction container configured to perform an enzymatic reaction, the reaction container including a base portion which has a container-shaped portion and a low-adsorption structural portion which is provided on at least the inner surface of the container-shaped portion, the low-adsorption structural portion having an adsorption rate lower than the base portion at which at least one of a sample which becomes a target of analysis in the enzymatic reaction and a reagent for the enzymatic reaction is adsorbed thereonto, wherein a signal resulting from the enzymatic reaction is configured to be detected when the enzymatic reaction is performed in the reaction container.Type: GrantFiled: July 27, 2016Date of Patent: March 1, 2022Assignee: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Tomoko Kunitomi
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Patent number: 11260115Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.Type: GrantFiled: May 14, 2021Date of Patent: March 1, 2022Assignee: IMMATICS BIOTECHNOLOGIES GMBHInventors: Andrea Mahr, Toni Weinschenk, Anita Wiebe, Oliver Schoor, Jens Fritsche, Harpreet Singh
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Patent number: 11261500Abstract: Differentially expressed miRNA or small mRNA in the culture media of embryos were found to correlate to and affect embryo developmental fate. Accordingly the present invention provides a method for selecting a bovine embryo for implantation into a female bovine animal for further development based on the levels of specific miRNA or small mRNA. Also provided are methods of improving bovine embryo development fate by reducing in the culture medium the level of selected miRNAs.Type: GrantFiled: February 19, 2019Date of Patent: March 1, 2022Assignee: Wisconsin Alumni Research FoundationInventor: Hasan Khatib