With Conveyance Of Sample Along A Test Line In A Container Or Rack Patents (Class 436/47)
  • Patent number: 8252233
    Abstract: A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: August 28, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hitoshi Tokieda, Yoshimitsu Takagi, Takeshi Shibuya, Masashi Akutsu
  • Patent number: 8252234
    Abstract: An apparatus is provided for producing pharmaceutical and pharmaceutical-like product. The apparatus provides real-time monitoring of the pharmaceutical product and can provide real-time control. The apparatus monitors the dosage both before and after it has been added to a carrier substrate. The apparatus can provide monitoring of each pharmaceutical product that is processed.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: August 28, 2012
    Assignee: SmithKline Beecham Corporation
    Inventors: Allan J. Clarke, David George Doughty, Frederick H. Fiesser, David S. Wagner
  • Patent number: 8231830
    Abstract: A sample analyzer: measures a measurement sample including a sample and a reagent; creates a calibration curve based on first measurement data obtained by measuring a measurement standard sample including a standard sample and the reagent; provides calibration curve specifying information for specifying the calibration curve to the calibration curve; acquires an analysis result by processing second measurement data obtained by measuring the measurement sample based on the calibration curve; and stores the analysis result and the calibration curve specifying information provided to the calibration curve used in the process of the second measurement data in correspondence to each other.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: July 31, 2012
    Assignee: Sysmex Corporation
    Inventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
  • Patent number: 8232103
    Abstract: A method for replacing a first sample carried on a moving secondary conveyor onto a moving primary conveyor at a potential interference point while the primary conveyor is transporting a second sample.
    Type: Grant
    Filed: August 8, 2006
    Date of Patent: July 31, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Kerry Lynn Miller, Frank Jay Robb, Peter Louis Gebrian, Sandor Lajos Kovacs
  • Patent number: 8226889
    Abstract: A sample processing system is disclosed that comprising: a first sample processing apparatus; a second sample processing apparatus; a third sample processing apparatus; a first moving mechanism for moving, in a first direction, the second sample processing apparatus and the third sample processing apparatus relative to the first sample processing apparatus; and a second moving mechanism for moving, in a second direction crossing the first direction, at least one among the second sample processing apparatus and the third sample processing apparatus.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: July 24, 2012
    Assignee: Sysmex Corporation
    Inventor: Masanori Nakaya
  • Patent number: 8222048
    Abstract: A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction vessels enables the laboratory automation system to assume a variety of arrangements, i.e., the laboratory automation system can comprise a variety of functional modules that can be arranged in various ways. In order to effectively carry out immunoassays by means of micro-well plates, a technique known as inverse magnetic particle processing can be used to transfer the product(s) of immunoassays from one micro-well of a micro-well plate to another.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: July 17, 2012
    Assignee: Abbott Laboratories
    Inventors: Patrick P. Fritchie, Gregory E. Gardner, Richard W. Mahoney
  • Publication number: 20120178170
    Abstract: An intelligent rack automatically detects the position of a specimen tube within a multiple specimen tube containing rack such as that utilized within automatic specimen processing apparatuses. The rack has a plurality of positions with a moving element located adjacent each position. The moving element, such as a spring, is positioned so that it moves when a specimen tube is placed within an adjacent position. A magnet or other sensor on the moving element interacts with a detector to sense when a particular position has received a specimen tube. A computer controlling the apparatus receives specimen information for each specimen tube and has an identifier for the specimen tube, such as a bar code, scanned into the computer before placement of the specimen tube into a rack position. Removal of the specimen tube from a position on the rack causes correlating removal of specimen tube position information from the computer.
    Type: Application
    Filed: July 16, 2010
    Publication date: July 12, 2012
    Inventor: Peter Van Praet
  • Patent number: 8216512
    Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: July 10, 2012
    Assignee: DAKO Denmark A/S
    Inventors: Lars Winther, Marc Key, Kristopher S. Buchanan, John Favuzzi, Benno Guggenheimer
  • Patent number: 8211381
    Abstract: A device for measuring the sedimentation rate in biological fluids, and particularly the erythrocyte sedimentation rate in blood samples. The device comprises: holders (3) for test tubes (P) containing samples of biological fluid; agitator devices (25) for agitating the test tubes; at least one detector (17, 19) for reading the levels inside the test tubes. The holders together form a continuous flexible member (1) defining a closed path along which the agitator devices and the detector are arranged.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: July 3, 2012
    Assignee: Diesse Diagnostica Senese S.p.A.
    Inventors: Antonio Ricci, Michele Meloni, Francesco Cocola
  • Patent number: 8211367
    Abstract: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step, an additive and particles are added to the sample, wherein the additive substantially binds to the at least one of the stem cell, lymphocyte, and leukocyte, and the particles and wherein the particles substantially bind to the at least one of the stem cell, lymphocyte, and leukocyte, and the additive, thereby producing a cell-containing network. In a further step, the network is separated from the substantially cell-depleted portion by applying a magnetic force.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: July 3, 2012
    Inventors: James Wyatt, Matthew Scott, Vijay Mahant
  • Patent number: 8198090
    Abstract: A cartridge is provided that can remove a residual liquid all around the leading end of a pipette, without requiring any new equipment, regardless of the viscosity of the residual liquid. This cartridge includes a plurality of tanks, each of which has an upper opening, and a liquid is introduced into or led out from at least one of the plurality of tanks 110 to 119 with a pipette. The cartridge further includes waste liquid tanks 120 to 122. The waste liquid tanks 120 to 122 each includes a capillary phenomenon generation portion. A residual liquid present at the leading end of the pipette is brought into contact with the capillary phenomenon generation portion of the waste liquid tanks, and the residual liquid is transferred to the capillary phenomenon generation portion through the capillary phenomenon to be removed from the pipette.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: June 12, 2012
    Assignee: ARKRAY, Inc.
    Inventors: Kosuke Kubo, Junichi Oka
  • Patent number: 8187536
    Abstract: A system (100) and a method for the unequivocal allocation of histological cassettes (30) and specimen slides (60) is described. The system encompasses a microtome (1) and at least one reading unit (80). The data (33) of the histological cassette (30) and the data (33) of the at least one specimen slide (60) are read by means of the reading unit (80). The reading unit (80) is provided with at least one indicating element (83) that outputs a signal in accordance with the degree of correspondence between the data (33) of the histological cassette (30) and the data (33) on the specimen slide (60).
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: May 29, 2012
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Dag Graupner, Rolf Metzner
  • Patent number: 8178043
    Abstract: Embodiments directed to a device for analyzing samples administered from a sample vessel are disclosed. One embodiment may comprise a central unit having a supply of reaction vessels and a sampling unit by which at least part of a sample is transferred from one of the sample vessels into the reaction vessel; at least one analytical unit having a plurality of reagent vessels; a transport unit which transports at least part of the reaction vessels from the central unit to the analytical unit such that the analytical unit supplies the reagent from the reagent vessels into the reaction vessel for triggering a reaction between the sample and the reagent; and at least one measuring unit provided in the analytical unit which measures the physical property of the sample held in the reaction vessel.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: May 15, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudius Burkhardt, Mathias Juch, Gottlieb Schacher, Leo Schwerzmann
  • Publication number: 20120094388
    Abstract: A cassette is described which can hold at least two multiwell plates. The cassette comprising the multiwell plates can be loaded into a stacker of an automated analytical apparatus. While the stacker holds down the cassette, a lift pushes the multiwell plates upwards to make them accessible to a handler which can engage and transport the multiwell plates to a plate holder in the working area of the analytical apparatus.
    Type: Application
    Filed: April 14, 2011
    Publication date: April 19, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Renato Belz, Christian Thalmann
  • Patent number: 8158060
    Abstract: A sample analyzer for analyzing a sample comprising: a sample container receiver capable of receiving either one of a manually supplied sample container and an automatically supplied; a container holder receiver for receiving a container holder holding at least one sample container; a sample container supplier automatically for supplying, to the sample container receiver, a sample container held by the container holder received by the container holder receiver; an aspirator for aspirating a sample within a sample container received by the sample container receiver; and an analyzing part for analyzing the sample aspirated by the aspirator.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: April 17, 2012
    Assignee: Sysmex Corporation
    Inventors: Takaaki Nagai, Mitsuo Yamasaki
  • Patent number: 8158061
    Abstract: A slide stainer assembly is disclosed. The slide stainer includes a slide carrier that is configured to carry one or more laboratory slides and a plurality of slide processing stations for processing the slides. A transport member including a plurality of engagement portions is configured for releasably engaging the slide carrier. A drive mechanism is coupled to the transport member. The drive mechanism is configured to move the transport member in a cyclical path such that, in the course of one cycle, the transport member engages a slide carrier docked in a first station, removes the slide carrier from the first station, docks the slide carrier in a second station and returns to the first station to engage another slide carrier.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: April 17, 2012
    Assignee: Rushabh Instruments, LLC
    Inventors: Preyas Shah, Leonard C. Wagner
  • Patent number: 8147778
    Abstract: A specimen container carrier for a conveyor in a laboratory automation system which includes a circular body driven by the conveyor and container holding elements arranged in the circular body, the container holding elements being maintained in a container holding position by respective elastic elements and are connected to each other by synchronization elements forcing the specimen container to remain coaxially positioned with respect to the circular body.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: April 3, 2012
    Assignee: Inpeco IP Ltd.
    Inventor: Gianandrea Pedrazzini
  • Patent number: 8142740
    Abstract: A rack for an automated processing system. The rack includes a number of wells adapted to hold at least a first sample container having a first size, and a second sample container having a second size. The second size, which may be a diameter, a height, or both, is substantially different from the first size. A structure joins the wells. The rack is adapted to fit in an automated processing system that is adapted to remove both the first sample container and the second sample container from the rack.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: March 27, 2012
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Brian Austin Self, James Hal Godsey
  • Patent number: 8143065
    Abstract: A specimen processing device comprising: a specimen processing unit for processing specimens; a first conveyance mechanism for conveying specimens from a carry-in side towards a carry-out side on the opposite side of the carry-in side with respect to the specimen processing unit through a specimen supply position for supplying specimens to the specimen processing unit; a second conveyance mechanism for conveying specimens from the carry-in side towards the carry-out side without passing the specimen supply position; a first control device for controlling the first conveyance mechanism; and a second control device for controlling the second conveyance mechanism, is disclosed. A specimen conveyance device and a specimen conveyance method are also disclosed.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: March 27, 2012
    Assignee: Sysmex Corporation
    Inventor: Hiroyuki Tanaka
  • Patent number: 8128870
    Abstract: A drug discovery screening apparatus improves a testing operation efficiency. The drug discovery screening apparatus comprises an image measurement unit, an incubator unit integrally connected to the image measurement unit, a fixed stage disposed at the incubator unit, first conveyance for taking out one of plates stored in a carousel of the incubator unit and conveying the plate onto the fixed stage, second conveyance for taking out the plate conveyed onto the fixed stage and conveying the plate onto an XY stage disposed at the image measurement unit, and a control unit. The second conveyance comprises first and second conveyance arms, respectively supported horizontally by a conveyance unit support section, which convey the plates onto the fixed stage and XY stage so as to allow the respective plates to cross each other.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: March 6, 2012
    Assignee: Yokogawa Electric Corporation
    Inventors: Taichirou Nedu, Kouichi Yamamoto, Takayuki Kei, Toshiyuki Suzuki
  • Patent number: 8105535
    Abstract: The present invention is to present a pipette tip supplier which is capable of convey the pipette tip smoothly. The pipette tip supplier 30 comprises: container 31 for containing pipette tips 3; separator 36 for separating pipette tips one by one; transporting section 37 for transporting pipette tips separated by the separator 36, one by one, to a first position via a second position and for dropping the transported pipette tips from the first position, the pipette tips transported by the transporting section 37 comprising a preceding pipette tip and a following pipette tip transported after the preceding pipette tip; detector 40e for detecting the following pipette tip at the second position before the following pipette tip arrives at the first position; and controller 2a for controlling the transporting section 37 so as to suspend transporting operation when the detector 40e detects the following pipette tip at the second position.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: January 31, 2012
    Assignee: Sysmex Corporation
    Inventors: Takeo Kowari, Takayoshi Izumi
  • Patent number: 8092743
    Abstract: A device for handling of laboratory samples includes at least one gripper movable from above over a sample. The gripper includes multiple fingers arranged around an axis, an elastic finger mount, and an actuator mechanism structured and arranged to move the fingers to selectively grip or release the sample. The multiple fingers are elastically held by the elastic finger mount in a radially displaceable manner.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: January 10, 2012
    Assignee: Liconic AG
    Inventor: Cosmas G. Malin
  • Patent number: 8083994
    Abstract: An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
    Type: Grant
    Filed: October 28, 2007
    Date of Patent: December 27, 2011
    Assignee: Brooks Automation, Inc.
    Inventors: Robert K. Neeper, Rhett L Affleck, John E. Lillig
  • Patent number: 8083995
    Abstract: The present invention is to present a sample processing system that is capable of reducing the tasks involved in the connection of the transporting apparatus. The sample processing system comprises: the transporting apparatus 11 for transporting the sample container 32 to a predetermined position; and the analyzer 10 for analyzing the sample contained in the sample container 32 transported to the predetermined position, the analyzer 10 comprising: the connection part 15 for connecting the transporting apparatus 11; the aspirating part 10a for aspirating the sample contained in the sample container 32; the apparatus body 12 for measuring the sample aspirated by the aspirating part 10a; the input part 29 for inputting identification information for identifying a type of the transporting apparatus 11; and the control unit 16 for controlling an operation of the transporting apparatus 11 based on the identification information input by the input part 29.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: December 27, 2011
    Assignee: Sysmex Corporation
    Inventors: Keisuke Tsutsumida, Ryuichiro Ebi, Rumi Takata, Akio Toyoda
  • Patent number: 8084260
    Abstract: Implementations of the present invention describe an apparatus for generating calibration factors for a spectral detector instrument. The calibration factors are derived from a calibration plate containing one or more spectral species in each well of the calibration plate. Each well is then exposed to an excitation source that causes the one or more spectral species in each of the wells to fluoresce. The signal response is measured and associated with each spectral species at each different well position in the calibration plate. Next, the measured signal response from each spectral species at each well position in the calibration plate is compared with a predetermined signal response for each spectral species. The results of this comparison can be used to determine a calibration factor for each well and spectral species to compensate for the difference between the measured signal response and the predetermined signal response.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: December 27, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Stephen J. Gunstream, Mark Oldham
  • Patent number: 8080204
    Abstract: A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positioned between the sample carrier and the conveyor; advancing the sample carrier beyond the fixed registration elements; reversing the conveyor direction to back at least one of the sample carriers into contact with its corresponding registration elements; continuing to reverse the conveyor until all sample carriers are in contact with their respective registration elements; whereby the flexure elements of the sample carriers in contact with the respective registration elements will deform as the conveyor reverses to allow all sample carriers to contact their respective registration elements, thereby providing a known position of the sample carrier.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: December 20, 2011
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Dale Ryan, Johannes Porte
  • Patent number: 8071029
    Abstract: A sample analyzer and sample analyzing method perform following: a) mixing a sample with at least one of a first reagent and a second reagent, thereby preparing a measurement specimen; b) storing, in a memory, standard curve data corresponding to a reagent to be used in the step a) for preparing a measurement specimen; c) measuring the measurement specimen thereby obtaining measurement data; d) processing the measurement data based on the standard curve data, thereby obtaining an analysis result; and e) when the first, reagent and the second reagent are of the same type, determining a reagent to be used for the measuring between the first reagent and the second reagent, based on information regarding standard curve data stored in the memory.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: December 6, 2011
    Assignee: Sysmex Corporation
    Inventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
  • Patent number: 8066959
    Abstract: An automatic analyzer capable of performing analysis in terms of a number of analysis items with high reliability through a simple operation. The automatic analyzer comprises a probe adapted to be moved on a circular arc path and capable of sucking or discharging a sample or reagent, a plurality of sample containers disposed at different positions on the path of the probe and containing different analyte samples, and a rotor capable of carrying a plurality of reagent cartridges. Each of the reagent cartridges comprises a photometric cuvette that is empty when not in use, and a reagent cuvette in which a reagent used for a particular analysis item is hermetically sealed. A two-dimensional code with information regarding the analyte type and analysis conditions, for example, is affixed to the reagent cartridge. The two-dimensional code information is read by a reading unit.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: November 29, 2011
    Assignee: Hitachi Chemical Company, Ltd.
    Inventors: Katsumi Ouchi, Hiroshi Mitsumaki
  • Patent number: 8062591
    Abstract: The clinical laboratory test apparatus includes: an analyzing unit for analyzing a specimen; a reception part for receiving specimen information before analysis of the specimen; a discrimination part for discriminating whether or not a specimen is suited for analysis based on the specimen information; and a control part for controlling the analyzing unit based on the discrimination result obtained by the discrimination part.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: November 22, 2011
    Assignee: Sysmex Corporation
    Inventor: Norimasa Yamamoto
  • Publication number: 20110244582
    Abstract: A sample processing apparatus comprising: a plurality of testing units arranged along a transport path and each configured to perform at least one type of test; a plurality of transport units configured to collectively constitute the transport path and collectively function to deliver samples to the plurality of testing units for testing; and at least one processor of a computer system and at least one memory that stores programs executable by the at least one processor to: (a) determine a type of test required to be performed on a sample; (b) if a trouble of a transport unit is reported, determine whether there is an available testing unit performable of the required type of test to which the sample is deliverable; (c) if there is the available testing unit, instruct to transport the sample to the available testing unit.
    Type: Application
    Filed: March 28, 2011
    Publication date: October 6, 2011
    Inventor: Hiroo Tatsutani
  • Patent number: 8030079
    Abstract: A hand-held video gaming device comprises a games console comprising a disc reader module configured to load a game stored on a disc; a printer module configured to print game information on print media, the printer module being hingedly mounted above the games console, and functioning as a pivotable cover for the game console; and a controller module releasably engaged with the printer module, and configured to communicate wirelessly with the games console to enable control of the games console.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: October 4, 2011
    Assignee: Silverbrook Research Pty Ltd
    Inventor: Kia Silverbrook
  • Publication number: 20110236980
    Abstract: An apparatus and method based on the apparatus is disclosed for automated single molecule or molecular assemblage detection via light irradiation and detection of transient FRET between a donor or acceptor bound to an immobilized single molecule or molecular assemblage and a corresponding acceptor or donor associated with, covalently bonded to, a reagent, where the donor or acceptor associated with the reagent is transiently in FRET proximity to the acceptor or donor associated with the immobilized molecule or molecular assemblage.
    Type: Application
    Filed: January 6, 2011
    Publication date: September 29, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: Michael A. Rea
  • Patent number: 8003050
    Abstract: A device for analyzing samples is disclosed, which are supplied in sample vessels (2), a central unit (1) with reaction vessels (2), a transport unit (6) for transporting the reaction vessels and at least one analytical unit (7, 8, 9) being provided. The central unit (1) contains a sampling unit (30), by which at least a part of the sample is transferred from the sample vessel (2) to a reaction vessel. At least a part of the reaction vessels is transferred via/by the transport unit (6) to at least one of the analytical units (7, 8, 9). Furthermore, at least one reagent vessel (20, . . . , 23) with at least one reagent is provided, which is supplied to the sample in the reaction vessel for a reaction between the sample and the reagent. Finally, at least one measuring device (5) or at least one measuring unit for the measuring of a physical property of the sample is provided. The device according to the invention works extremely efficiently, simultaneously a minimal effort of resources being required.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: August 23, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudius Burkhardt, Mathias Juch, Gottlieb Schacher, Leo Schwerzmann
  • Patent number: 7998432
    Abstract: The device comprises reaction unit cuvettes (22) for different types of tests, a vertical axis rotor (7) which is associated with a rotation drive means and provided with a horizontal gear-teeth crown (8) delimiting radially outwardly open cavities for receiving the reaction unit cuvettes (22), a device (20) for supplying the gear-teeth crown with the reaction unit cuvettes (22), a device (6) for supplying cuvettes with analyzable biological liquid samples, stations (13, 19) arranged around the crown for carrying out measurements and/or analysis and an automation for managing the sequences of a desired process for each cuvette.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: August 16, 2011
    Assignees: Immunodiagnostic System France
    Inventor: Alain Rousseau
  • Patent number: 7998409
    Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: August 16, 2011
    Assignee: Beckman Coulter, Inc.
    Inventors: Craig R. Veiner, Frank M. Tappen, Roberto Del Valle
  • Patent number: 7977100
    Abstract: Provided is a punching apparatus for use in dispensing, having a blood specimen contained therein, and punching a dispensing hole in a plug body of a test tube serving as a specimen container closed by the plug body whose upper end opening is made of a rubber or synthetic resin material, the apparatus comprising a guide rail serving as a transport passage which transports the test tube while the plug body thereof is held at the upper side in a vertical state, an elevating mechanism provided at a punch position P in the middle of the guide rail, and an ultrasonic cutter which is supported by the elevating mechanism, and which is lowered when the test tube reaches the punch position, thereby punching a dispensing hole immediately before penetrating the plug body from a top face thereof.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: July 12, 2011
    Assignee: IDS Company, Ltd.
    Inventor: Teruaki Itoh
  • Patent number: 7968051
    Abstract: A clinical laboratory apparatus includes a plurality of reaction cuvettes, a first dispenser, a second dispenser, a controller, and an analyzer. A subject sample and a reagent are mixed in each of the plurality of reaction cuvettes. The first dispenser is configured to dispense the subject sample into each of the plurality of reaction cuvettes. The second dispenser is configured to dispense the reagent into each of the plurality of reaction cuvettes so that the subject sample and the reagent are mixed. The controller is configured to categorize the plurality of reaction cuvettes into at least first and second groups, to designate at least first and second analysis items among two or more analysis items with respect to the subject sample, to control the second dispenser to avoid dispensing the reagent relevant to the first analysis item into the second group of the reaction cuvettes. The analyzer is configured to analyze a mixed result.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: June 28, 2011
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Takehiko Oonuma
  • Patent number: 7964413
    Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: June 21, 2011
    Assignee: Gen-Probe Incorporated
    Inventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
  • Patent number: 7960183
    Abstract: Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, having the steps of filling a retention liquid which separates without getting mixed with the sample liquid into the liquid housing unit, the passage, and the cavity; injecting the sample liquid into the liquid housing unit; moving the sample liquid from the liquid housing unit to the cavity by discharging the retention liquid from the nozzle hole; stopping the discharge of the retention liquid at the moving step upon detecting with a sensor that the sample liquid reached a position adjacent to the nozzle hole; and delivering the sample liquid as droplets onto the object by discharging the sample liquid from the nozzle hole.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: June 14, 2011
    Assignee: Seiko Epson Corporation
    Inventor: Hiroshi Koeda
  • Patent number: 7955863
    Abstract: Microfluidic devices for manipulating relatively dense materials, such as colloidal rod particles, are provided. Microfluidic devices for separating a denser first material from a less-dense second material are provided. Methods of manipulating a relatively dense first material, for example, colloidal rod particles, and separating the first material from a less-dense second material, are provided. Methods of marking samples or sample components with relatively dense materials, are also provided.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: June 7, 2011
    Assignee: Applied Biosystems, LLC
    Inventor: David Cox
  • Patent number: 7955556
    Abstract: An analyzer capable of operating in a normal processing mode performing sequential analysis of a plurality of specimens and in an interrupting mode performing analysis of an urgent specimen that comprising a suction unit for suctioning an urgent specimen, an analysis unit for analyzing an urgent specimen suctioned by the suction unit, an urgent specimen container holder for holding an urgent specimen container containing an urgent specimen, and a moving mechanism for moving the urgent specimen container holder between a placement position at which an urgent specimen container is placed in the holder, and a suction position at which an urgent specimen is suctioned from an urgent specimen container, wherein the moving mechanism comprises a movement force supplying mechanism for supplying a force to move the urgent specimen container holder from the suction position to the placement position is disclosed.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: June 7, 2011
    Assignee: Sysmex Corporation
    Inventors: Hiroki Koike, Masayuki Ikeda
  • Patent number: 7951329
    Abstract: A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within the read station, a housing and shield eliminates light leakage from the sample under test. In addition, the read station regulates the intensity of the light by providing an attenuation capability.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: May 31, 2011
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ilya Malyarov, Thomas Palmieri
  • Patent number: 7947225
    Abstract: A automated test tube cap removal apparatus includes, a cap remover, a test tube rack which holds a plurality of capped test tubes upright in a row, a clamping mechanism which is disposed in the cap removing position and clamps the plurality of test tubes, and a cap removal unit disposed in the cap removing position and configured to move upward to remove caps from some of a plurality of test tubes and move upward to remove caps from the remaining test tubes. The cap removal unit includes engaging members which are capable of advance and retreat with respect to the caps and clamp each cap, a lift mechanism which raises the engaging members while alternately moving the engaging members upward, thereby removing the cap from each test tube, a cap guide member which separates the cap and guides the cap for dropping.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: May 24, 2011
    Assignee: IDS Co., Ltd.
    Inventor: Teruaki Itoh
  • Patent number: 7943100
    Abstract: The device comprises reaction unit cuvettes for different types of tests, a vertical axis rotor which is associated with a rotation drive means and provided with a horizontal gear-teeth crown delimiting radially outwardly open cavities for receiving the reaction unit cuvettes, a device for supplying the gear-teeth crown with the reaction unit cuvettes, a device for supplying cuvettes with analyzable biological liquid samples, stations arranged around the crown for carrying out measurements and/or analysis and an automation for managing the sequences of a desired process for each cuvette.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: May 17, 2011
    Assignees: Immunodiagnostic System France
    Inventor: Alain Rousseau
  • Patent number: 7939023
    Abstract: A sensor unit is retained on an assay stage of a surface plasmon resonance (SPR) assay apparatus. The sensor unit includes a prism having a sensing surface, disposed on an upper surface thereof, for detecting reaction of a sample. A flow cell is secured to the upper surface, and has a flow channel for flow of sample fluid containing the sample to the sensing surface. The sensor unit is set removably on the assay apparatus for optically measuring reaction of the sample. In sensor holding, the sensor unit is set on a stage surface of the assay stage by directing down the prism. In a pushing step, a lower surface of the prism is pushed on the stage surface in a first direction upright relative to the stage surface. Two holders push an upper face of the first and second ridges of the prism in the first direction.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: May 10, 2011
    Assignee: FUJIFILM Corporation
    Inventor: Yoshiyuki Kunuki
  • Patent number: 7939020
    Abstract: An automatic analyzing apparatus has an analysis section including an immunity analysis unit and a biochemical componential analysis unit. A sample rack which has undergone the immunity componential analysis is horizontally fed by a rack feeding mechanism from a position confronting the inlet of a rack stationing section to a position near the outlet of the rack stationing section, so that the sample rack is directly moved to a return line, while skipping over the rack stationing section, so as to be efficiently returned to the analysis section and subjected to a subsequent biochemical analysis. A sample rack that needs reexamination by an identical analysis unit is also returned in the same efficient way.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: May 10, 2011
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Keiko Nogawa, Michiaki Sekiguchi, Hiroshi Watanabe, Hiroaki Ishizawa, Terumi Tamura
  • Patent number: 7932090
    Abstract: Apparatus and methods for positioning the process chambers of microfluidic sample processing devices in the proper focal plane of a microplate reader are disclosed. The apparatus and methods may be adaptable to position the sample processing devices at different heights as may be necessary for processing in different microplate readers. A positioning device is used in connection with the sample processing device to locate the process chambers within the focal plane of the microplate reader.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: April 26, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Chad J. Carter, Christopher R. Kokaisel, Kenneth B. Wood
  • Patent number: 7927876
    Abstract: A multiple cuvette strip comprises a plurality of wells and a reversible interlocking device. The well strips can be reversibly interlocked to other well strips to form a sample holder system. One embodiment of a well strip comprises a flange and a slot to form a reversible interlocking device.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: April 19, 2011
    Inventors: Matthew R. Blouin, Robert R. Fisette
  • Patent number: 7927545
    Abstract: A container with a rotatable lid for reading and handling diagnostic reagents in tape form comprising a body portion, a lid portion, a continuous tape, a reagent-sensing device, and a storage device. The body portion includes an inner and outer surface. The lid portion is attached to the body portion and is adapted to rotate from a closed position to an open position. The continuous tape includes a diagnostic reagent. The reagent-sensing device is attached to either the body portion or the lid portion and adapted to read the diagnostic reagent. The storage device is attached to the body portion that is adapted to hold and dispense an unused portion of the continuous tape. During the rotation of the lid portion, the continuous tape is advanced from the first storage device and is extended over the reagent-sensing device.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: April 19, 2011
    Assignee: Bayer HealthCare LLC
    Inventor: Steven C. Charlton
  • Patent number: 7910061
    Abstract: In a colorimetric absorbance measurement apparatus, a filter assembly on which a plurality of filters are arranged in a circular pattern is continuously rotated by a motor at a regular speed based on a motor drive signal fed from a motor drive circuit, each of the filters being characterized by passing only such light components that have wavelengths falling within a range centering on a specific wavelength. The motor drive signal produced by the motor drive circuit is also fed into a timing generator circuit. The timing generator circuit supplies an A/D conversion start signal to an A/D converter in synchronism with the timing at which a selected one of the multiple filters is positioned on the optical axis of a measuring light beam.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: March 22, 2011
    Assignee: Furuno Electric Company, Limited
    Inventors: Yasuhiro Higuchi, Yoshinori Fujiwara