With Conveyance Of Sample Along A Test Line In A Container Or Rack Patents (Class 436/47)
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Patent number: 8252233Abstract: A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.Type: GrantFiled: December 23, 2008Date of Patent: August 28, 2012Assignee: Hitachi High-Technologies CorporationInventors: Hitoshi Tokieda, Yoshimitsu Takagi, Takeshi Shibuya, Masashi Akutsu
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Patent number: 8252234Abstract: An apparatus is provided for producing pharmaceutical and pharmaceutical-like product. The apparatus provides real-time monitoring of the pharmaceutical product and can provide real-time control. The apparatus monitors the dosage both before and after it has been added to a carrier substrate. The apparatus can provide monitoring of each pharmaceutical product that is processed.Type: GrantFiled: June 9, 2005Date of Patent: August 28, 2012Assignee: SmithKline Beecham CorporationInventors: Allan J. Clarke, David George Doughty, Frederick H. Fiesser, David S. Wagner
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Patent number: 8231830Abstract: A sample analyzer: measures a measurement sample including a sample and a reagent; creates a calibration curve based on first measurement data obtained by measuring a measurement standard sample including a standard sample and the reagent; provides calibration curve specifying information for specifying the calibration curve to the calibration curve; acquires an analysis result by processing second measurement data obtained by measuring the measurement sample based on the calibration curve; and stores the analysis result and the calibration curve specifying information provided to the calibration curve used in the process of the second measurement data in correspondence to each other.Type: GrantFiled: March 18, 2008Date of Patent: July 31, 2012Assignee: Sysmex CorporationInventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
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Patent number: 8232103Abstract: A method for replacing a first sample carried on a moving secondary conveyor onto a moving primary conveyor at a potential interference point while the primary conveyor is transporting a second sample.Type: GrantFiled: August 8, 2006Date of Patent: July 31, 2012Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Kerry Lynn Miller, Frank Jay Robb, Peter Louis Gebrian, Sandor Lajos Kovacs
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Patent number: 8226889Abstract: A sample processing system is disclosed that comprising: a first sample processing apparatus; a second sample processing apparatus; a third sample processing apparatus; a first moving mechanism for moving, in a first direction, the second sample processing apparatus and the third sample processing apparatus relative to the first sample processing apparatus; and a second moving mechanism for moving, in a second direction crossing the first direction, at least one among the second sample processing apparatus and the third sample processing apparatus.Type: GrantFiled: November 30, 2007Date of Patent: July 24, 2012Assignee: Sysmex CorporationInventor: Masanori Nakaya
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Patent number: 8222048Abstract: A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction vessels enables the laboratory automation system to assume a variety of arrangements, i.e., the laboratory automation system can comprise a variety of functional modules that can be arranged in various ways. In order to effectively carry out immunoassays by means of micro-well plates, a technique known as inverse magnetic particle processing can be used to transfer the product(s) of immunoassays from one micro-well of a micro-well plate to another.Type: GrantFiled: October 24, 2008Date of Patent: July 17, 2012Assignee: Abbott LaboratoriesInventors: Patrick P. Fritchie, Gregory E. Gardner, Richard W. Mahoney
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Publication number: 20120178170Abstract: An intelligent rack automatically detects the position of a specimen tube within a multiple specimen tube containing rack such as that utilized within automatic specimen processing apparatuses. The rack has a plurality of positions with a moving element located adjacent each position. The moving element, such as a spring, is positioned so that it moves when a specimen tube is placed within an adjacent position. A magnet or other sensor on the moving element interacts with a detector to sense when a particular position has received a specimen tube. A computer controlling the apparatus receives specimen information for each specimen tube and has an identifier for the specimen tube, such as a bar code, scanned into the computer before placement of the specimen tube into a rack position. Removal of the specimen tube from a position on the rack causes correlating removal of specimen tube position information from the computer.Type: ApplicationFiled: July 16, 2010Publication date: July 12, 2012Inventor: Peter Van Praet
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Patent number: 8216512Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.Type: GrantFiled: December 19, 2003Date of Patent: July 10, 2012Assignee: DAKO Denmark A/SInventors: Lars Winther, Marc Key, Kristopher S. Buchanan, John Favuzzi, Benno Guggenheimer
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Patent number: 8211381Abstract: A device for measuring the sedimentation rate in biological fluids, and particularly the erythrocyte sedimentation rate in blood samples. The device comprises: holders (3) for test tubes (P) containing samples of biological fluid; agitator devices (25) for agitating the test tubes; at least one detector (17, 19) for reading the levels inside the test tubes. The holders together form a continuous flexible member (1) defining a closed path along which the agitator devices and the detector are arranged.Type: GrantFiled: October 21, 2004Date of Patent: July 3, 2012Assignee: Diesse Diagnostica Senese S.p.A.Inventors: Antonio Ricci, Michele Meloni, Francesco Cocola
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Patent number: 8211367Abstract: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step, an additive and particles are added to the sample, wherein the additive substantially binds to the at least one of the stem cell, lymphocyte, and leukocyte, and the particles and wherein the particles substantially bind to the at least one of the stem cell, lymphocyte, and leukocyte, and the additive, thereby producing a cell-containing network. In a further step, the network is separated from the substantially cell-depleted portion by applying a magnetic force.Type: GrantFiled: January 18, 2011Date of Patent: July 3, 2012Inventors: James Wyatt, Matthew Scott, Vijay Mahant
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Patent number: 8198090Abstract: A cartridge is provided that can remove a residual liquid all around the leading end of a pipette, without requiring any new equipment, regardless of the viscosity of the residual liquid. This cartridge includes a plurality of tanks, each of which has an upper opening, and a liquid is introduced into or led out from at least one of the plurality of tanks 110 to 119 with a pipette. The cartridge further includes waste liquid tanks 120 to 122. The waste liquid tanks 120 to 122 each includes a capillary phenomenon generation portion. A residual liquid present at the leading end of the pipette is brought into contact with the capillary phenomenon generation portion of the waste liquid tanks, and the residual liquid is transferred to the capillary phenomenon generation portion through the capillary phenomenon to be removed from the pipette.Type: GrantFiled: October 4, 2007Date of Patent: June 12, 2012Assignee: ARKRAY, Inc.Inventors: Kosuke Kubo, Junichi Oka
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Patent number: 8187536Abstract: A system (100) and a method for the unequivocal allocation of histological cassettes (30) and specimen slides (60) is described. The system encompasses a microtome (1) and at least one reading unit (80). The data (33) of the histological cassette (30) and the data (33) of the at least one specimen slide (60) are read by means of the reading unit (80). The reading unit (80) is provided with at least one indicating element (83) that outputs a signal in accordance with the degree of correspondence between the data (33) of the histological cassette (30) and the data (33) on the specimen slide (60).Type: GrantFiled: December 3, 2010Date of Patent: May 29, 2012Assignee: Leica Biosystems Nussloch GmbHInventors: Dag Graupner, Rolf Metzner
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Patent number: 8178043Abstract: Embodiments directed to a device for analyzing samples administered from a sample vessel are disclosed. One embodiment may comprise a central unit having a supply of reaction vessels and a sampling unit by which at least part of a sample is transferred from one of the sample vessels into the reaction vessel; at least one analytical unit having a plurality of reagent vessels; a transport unit which transports at least part of the reaction vessels from the central unit to the analytical unit such that the analytical unit supplies the reagent from the reagent vessels into the reaction vessel for triggering a reaction between the sample and the reagent; and at least one measuring unit provided in the analytical unit which measures the physical property of the sample held in the reaction vessel.Type: GrantFiled: July 11, 2011Date of Patent: May 15, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudius Burkhardt, Mathias Juch, Gottlieb Schacher, Leo Schwerzmann
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Publication number: 20120094388Abstract: A cassette is described which can hold at least two multiwell plates. The cassette comprising the multiwell plates can be loaded into a stacker of an automated analytical apparatus. While the stacker holds down the cassette, a lift pushes the multiwell plates upwards to make them accessible to a handler which can engage and transport the multiwell plates to a plate holder in the working area of the analytical apparatus.Type: ApplicationFiled: April 14, 2011Publication date: April 19, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Renato Belz, Christian Thalmann
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Patent number: 8158060Abstract: A sample analyzer for analyzing a sample comprising: a sample container receiver capable of receiving either one of a manually supplied sample container and an automatically supplied; a container holder receiver for receiving a container holder holding at least one sample container; a sample container supplier automatically for supplying, to the sample container receiver, a sample container held by the container holder received by the container holder receiver; an aspirator for aspirating a sample within a sample container received by the sample container receiver; and an analyzing part for analyzing the sample aspirated by the aspirator.Type: GrantFiled: November 15, 2006Date of Patent: April 17, 2012Assignee: Sysmex CorporationInventors: Takaaki Nagai, Mitsuo Yamasaki
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Patent number: 8158061Abstract: A slide stainer assembly is disclosed. The slide stainer includes a slide carrier that is configured to carry one or more laboratory slides and a plurality of slide processing stations for processing the slides. A transport member including a plurality of engagement portions is configured for releasably engaging the slide carrier. A drive mechanism is coupled to the transport member. The drive mechanism is configured to move the transport member in a cyclical path such that, in the course of one cycle, the transport member engages a slide carrier docked in a first station, removes the slide carrier from the first station, docks the slide carrier in a second station and returns to the first station to engage another slide carrier.Type: GrantFiled: December 10, 2008Date of Patent: April 17, 2012Assignee: Rushabh Instruments, LLCInventors: Preyas Shah, Leonard C. Wagner
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Patent number: 8147778Abstract: A specimen container carrier for a conveyor in a laboratory automation system which includes a circular body driven by the conveyor and container holding elements arranged in the circular body, the container holding elements being maintained in a container holding position by respective elastic elements and are connected to each other by synchronization elements forcing the specimen container to remain coaxially positioned with respect to the circular body.Type: GrantFiled: October 11, 2006Date of Patent: April 3, 2012Assignee: Inpeco IP Ltd.Inventor: Gianandrea Pedrazzini
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Patent number: 8142740Abstract: A rack for an automated processing system. The rack includes a number of wells adapted to hold at least a first sample container having a first size, and a second sample container having a second size. The second size, which may be a diameter, a height, or both, is substantially different from the first size. A structure joins the wells. The rack is adapted to fit in an automated processing system that is adapted to remove both the first sample container and the second sample container from the rack.Type: GrantFiled: November 12, 2009Date of Patent: March 27, 2012Assignee: Qiagen Gaithersburg, Inc.Inventors: Brian Austin Self, James Hal Godsey
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Patent number: 8143065Abstract: A specimen processing device comprising: a specimen processing unit for processing specimens; a first conveyance mechanism for conveying specimens from a carry-in side towards a carry-out side on the opposite side of the carry-in side with respect to the specimen processing unit through a specimen supply position for supplying specimens to the specimen processing unit; a second conveyance mechanism for conveying specimens from the carry-in side towards the carry-out side without passing the specimen supply position; a first control device for controlling the first conveyance mechanism; and a second control device for controlling the second conveyance mechanism, is disclosed. A specimen conveyance device and a specimen conveyance method are also disclosed.Type: GrantFiled: October 2, 2009Date of Patent: March 27, 2012Assignee: Sysmex CorporationInventor: Hiroyuki Tanaka
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Patent number: 8128870Abstract: A drug discovery screening apparatus improves a testing operation efficiency. The drug discovery screening apparatus comprises an image measurement unit, an incubator unit integrally connected to the image measurement unit, a fixed stage disposed at the incubator unit, first conveyance for taking out one of plates stored in a carousel of the incubator unit and conveying the plate onto the fixed stage, second conveyance for taking out the plate conveyed onto the fixed stage and conveying the plate onto an XY stage disposed at the image measurement unit, and a control unit. The second conveyance comprises first and second conveyance arms, respectively supported horizontally by a conveyance unit support section, which convey the plates onto the fixed stage and XY stage so as to allow the respective plates to cross each other.Type: GrantFiled: February 12, 2010Date of Patent: March 6, 2012Assignee: Yokogawa Electric CorporationInventors: Taichirou Nedu, Kouichi Yamamoto, Takayuki Kei, Toshiyuki Suzuki
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Patent number: 8105535Abstract: The present invention is to present a pipette tip supplier which is capable of convey the pipette tip smoothly. The pipette tip supplier 30 comprises: container 31 for containing pipette tips 3; separator 36 for separating pipette tips one by one; transporting section 37 for transporting pipette tips separated by the separator 36, one by one, to a first position via a second position and for dropping the transported pipette tips from the first position, the pipette tips transported by the transporting section 37 comprising a preceding pipette tip and a following pipette tip transported after the preceding pipette tip; detector 40e for detecting the following pipette tip at the second position before the following pipette tip arrives at the first position; and controller 2a for controlling the transporting section 37 so as to suspend transporting operation when the detector 40e detects the following pipette tip at the second position.Type: GrantFiled: September 17, 2008Date of Patent: January 31, 2012Assignee: Sysmex CorporationInventors: Takeo Kowari, Takayoshi Izumi
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Patent number: 8092743Abstract: A device for handling of laboratory samples includes at least one gripper movable from above over a sample. The gripper includes multiple fingers arranged around an axis, an elastic finger mount, and an actuator mechanism structured and arranged to move the fingers to selectively grip or release the sample. The multiple fingers are elastically held by the elastic finger mount in a radially displaceable manner.Type: GrantFiled: January 7, 2009Date of Patent: January 10, 2012Assignee: Liconic AGInventor: Cosmas G. Malin
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Patent number: 8083994Abstract: An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.Type: GrantFiled: October 28, 2007Date of Patent: December 27, 2011Assignee: Brooks Automation, Inc.Inventors: Robert K. Neeper, Rhett L Affleck, John E. Lillig
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Patent number: 8083995Abstract: The present invention is to present a sample processing system that is capable of reducing the tasks involved in the connection of the transporting apparatus. The sample processing system comprises: the transporting apparatus 11 for transporting the sample container 32 to a predetermined position; and the analyzer 10 for analyzing the sample contained in the sample container 32 transported to the predetermined position, the analyzer 10 comprising: the connection part 15 for connecting the transporting apparatus 11; the aspirating part 10a for aspirating the sample contained in the sample container 32; the apparatus body 12 for measuring the sample aspirated by the aspirating part 10a; the input part 29 for inputting identification information for identifying a type of the transporting apparatus 11; and the control unit 16 for controlling an operation of the transporting apparatus 11 based on the identification information input by the input part 29.Type: GrantFiled: February 21, 2008Date of Patent: December 27, 2011Assignee: Sysmex CorporationInventors: Keisuke Tsutsumida, Ryuichiro Ebi, Rumi Takata, Akio Toyoda
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Patent number: 8084260Abstract: Implementations of the present invention describe an apparatus for generating calibration factors for a spectral detector instrument. The calibration factors are derived from a calibration plate containing one or more spectral species in each well of the calibration plate. Each well is then exposed to an excitation source that causes the one or more spectral species in each of the wells to fluoresce. The signal response is measured and associated with each spectral species at each different well position in the calibration plate. Next, the measured signal response from each spectral species at each well position in the calibration plate is compared with a predetermined signal response for each spectral species. The results of this comparison can be used to determine a calibration factor for each well and spectral species to compensate for the difference between the measured signal response and the predetermined signal response.Type: GrantFiled: November 23, 2005Date of Patent: December 27, 2011Assignee: Applied Biosystems, LLCInventors: Stephen J. Gunstream, Mark Oldham
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Patent number: 8080204Abstract: A method for positioning a sample in a diagnostic analyzer includes: providing two or more sample carriers on a conveyor; providing a fixed registration element for each sample carrier at predetermined locations along the conveyor; providing a flexure device positioned between the sample carrier and the conveyor; advancing the sample carrier beyond the fixed registration elements; reversing the conveyor direction to back at least one of the sample carriers into contact with its corresponding registration elements; continuing to reverse the conveyor until all sample carriers are in contact with their respective registration elements; whereby the flexure elements of the sample carriers in contact with the respective registration elements will deform as the conveyor reverses to allow all sample carriers to contact their respective registration elements, thereby providing a known position of the sample carrier.Type: GrantFiled: January 11, 2011Date of Patent: December 20, 2011Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Dale Ryan, Johannes Porte
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Patent number: 8071029Abstract: A sample analyzer and sample analyzing method perform following: a) mixing a sample with at least one of a first reagent and a second reagent, thereby preparing a measurement specimen; b) storing, in a memory, standard curve data corresponding to a reagent to be used in the step a) for preparing a measurement specimen; c) measuring the measurement specimen thereby obtaining measurement data; d) processing the measurement data based on the standard curve data, thereby obtaining an analysis result; and e) when the first, reagent and the second reagent are of the same type, determining a reagent to be used for the measuring between the first reagent and the second reagent, based on information regarding standard curve data stored in the memory.Type: GrantFiled: March 27, 2008Date of Patent: December 6, 2011Assignee: Sysmex CorporationInventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
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Patent number: 8066959Abstract: An automatic analyzer capable of performing analysis in terms of a number of analysis items with high reliability through a simple operation. The automatic analyzer comprises a probe adapted to be moved on a circular arc path and capable of sucking or discharging a sample or reagent, a plurality of sample containers disposed at different positions on the path of the probe and containing different analyte samples, and a rotor capable of carrying a plurality of reagent cartridges. Each of the reagent cartridges comprises a photometric cuvette that is empty when not in use, and a reagent cuvette in which a reagent used for a particular analysis item is hermetically sealed. A two-dimensional code with information regarding the analyte type and analysis conditions, for example, is affixed to the reagent cartridge. The two-dimensional code information is read by a reading unit.Type: GrantFiled: May 19, 2005Date of Patent: November 29, 2011Assignee: Hitachi Chemical Company, Ltd.Inventors: Katsumi Ouchi, Hiroshi Mitsumaki
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Patent number: 8062591Abstract: The clinical laboratory test apparatus includes: an analyzing unit for analyzing a specimen; a reception part for receiving specimen information before analysis of the specimen; a discrimination part for discriminating whether or not a specimen is suited for analysis based on the specimen information; and a control part for controlling the analyzing unit based on the discrimination result obtained by the discrimination part.Type: GrantFiled: September 24, 2004Date of Patent: November 22, 2011Assignee: Sysmex CorporationInventor: Norimasa Yamamoto
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Publication number: 20110244582Abstract: A sample processing apparatus comprising: a plurality of testing units arranged along a transport path and each configured to perform at least one type of test; a plurality of transport units configured to collectively constitute the transport path and collectively function to deliver samples to the plurality of testing units for testing; and at least one processor of a computer system and at least one memory that stores programs executable by the at least one processor to: (a) determine a type of test required to be performed on a sample; (b) if a trouble of a transport unit is reported, determine whether there is an available testing unit performable of the required type of test to which the sample is deliverable; (c) if there is the available testing unit, instruct to transport the sample to the available testing unit.Type: ApplicationFiled: March 28, 2011Publication date: October 6, 2011Inventor: Hiroo Tatsutani
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Patent number: 8030079Abstract: A hand-held video gaming device comprises a games console comprising a disc reader module configured to load a game stored on a disc; a printer module configured to print game information on print media, the printer module being hingedly mounted above the games console, and functioning as a pivotable cover for the game console; and a controller module releasably engaged with the printer module, and configured to communicate wirelessly with the games console to enable control of the games console.Type: GrantFiled: June 10, 2009Date of Patent: October 4, 2011Assignee: Silverbrook Research Pty LtdInventor: Kia Silverbrook
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Publication number: 20110236980Abstract: An apparatus and method based on the apparatus is disclosed for automated single molecule or molecular assemblage detection via light irradiation and detection of transient FRET between a donor or acceptor bound to an immobilized single molecule or molecular assemblage and a corresponding acceptor or donor associated with, covalently bonded to, a reagent, where the donor or acceptor associated with the reagent is transiently in FRET proximity to the acceptor or donor associated with the immobilized molecule or molecular assemblage.Type: ApplicationFiled: January 6, 2011Publication date: September 29, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Michael A. Rea
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Patent number: 8003050Abstract: A device for analyzing samples is disclosed, which are supplied in sample vessels (2), a central unit (1) with reaction vessels (2), a transport unit (6) for transporting the reaction vessels and at least one analytical unit (7, 8, 9) being provided. The central unit (1) contains a sampling unit (30), by which at least a part of the sample is transferred from the sample vessel (2) to a reaction vessel. At least a part of the reaction vessels is transferred via/by the transport unit (6) to at least one of the analytical units (7, 8, 9). Furthermore, at least one reagent vessel (20, . . . , 23) with at least one reagent is provided, which is supplied to the sample in the reaction vessel for a reaction between the sample and the reagent. Finally, at least one measuring device (5) or at least one measuring unit for the measuring of a physical property of the sample is provided. The device according to the invention works extremely efficiently, simultaneously a minimal effort of resources being required.Type: GrantFiled: October 25, 2005Date of Patent: August 23, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudius Burkhardt, Mathias Juch, Gottlieb Schacher, Leo Schwerzmann
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Patent number: 7998432Abstract: The device comprises reaction unit cuvettes (22) for different types of tests, a vertical axis rotor (7) which is associated with a rotation drive means and provided with a horizontal gear-teeth crown (8) delimiting radially outwardly open cavities for receiving the reaction unit cuvettes (22), a device (20) for supplying the gear-teeth crown with the reaction unit cuvettes (22), a device (6) for supplying cuvettes with analyzable biological liquid samples, stations (13, 19) arranged around the crown for carrying out measurements and/or analysis and an automation for managing the sequences of a desired process for each cuvette.Type: GrantFiled: July 18, 2005Date of Patent: August 16, 2011Assignees: Immunodiagnostic System FranceInventor: Alain Rousseau
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Patent number: 7998409Abstract: A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an associated instrument in a workcell, as well as to transfer selected racks of specimen-containers to an adjacent and identical specimen-transport module associated with another clinical instrument of the workcell. Since the same transport system is used to both present specimens for aspiration and to transfer specimens between instruments, there is no need for two independent conveyances as is characteristic of the prior art. Preferably, the specimen-transport module includes a magnetic X/Y transport system that operates beneath a rack-supporting surface to advance racks in mutually perpendicular directions across a supporting surface via magnetic forces.Type: GrantFiled: September 21, 2007Date of Patent: August 16, 2011Assignee: Beckman Coulter, Inc.Inventors: Craig R. Veiner, Frank M. Tappen, Roberto Del Valle
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Patent number: 7977100Abstract: Provided is a punching apparatus for use in dispensing, having a blood specimen contained therein, and punching a dispensing hole in a plug body of a test tube serving as a specimen container closed by the plug body whose upper end opening is made of a rubber or synthetic resin material, the apparatus comprising a guide rail serving as a transport passage which transports the test tube while the plug body thereof is held at the upper side in a vertical state, an elevating mechanism provided at a punch position P in the middle of the guide rail, and an ultrasonic cutter which is supported by the elevating mechanism, and which is lowered when the test tube reaches the punch position, thereby punching a dispensing hole immediately before penetrating the plug body from a top face thereof.Type: GrantFiled: June 18, 2009Date of Patent: July 12, 2011Assignee: IDS Company, Ltd.Inventor: Teruaki Itoh
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Patent number: 7968051Abstract: A clinical laboratory apparatus includes a plurality of reaction cuvettes, a first dispenser, a second dispenser, a controller, and an analyzer. A subject sample and a reagent are mixed in each of the plurality of reaction cuvettes. The first dispenser is configured to dispense the subject sample into each of the plurality of reaction cuvettes. The second dispenser is configured to dispense the reagent into each of the plurality of reaction cuvettes so that the subject sample and the reagent are mixed. The controller is configured to categorize the plurality of reaction cuvettes into at least first and second groups, to designate at least first and second analysis items among two or more analysis items with respect to the subject sample, to control the second dispenser to avoid dispensing the reagent relevant to the first analysis item into the second group of the reaction cuvettes. The analyzer is configured to analyze a mixed result.Type: GrantFiled: November 30, 2004Date of Patent: June 28, 2011Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems CorporationInventor: Takehiko Oonuma
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Patent number: 7964413Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: June 21, 2011Assignee: Gen-Probe IncorporatedInventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
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Patent number: 7960183Abstract: Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, having the steps of filling a retention liquid which separates without getting mixed with the sample liquid into the liquid housing unit, the passage, and the cavity; injecting the sample liquid into the liquid housing unit; moving the sample liquid from the liquid housing unit to the cavity by discharging the retention liquid from the nozzle hole; stopping the discharge of the retention liquid at the moving step upon detecting with a sensor that the sample liquid reached a position adjacent to the nozzle hole; and delivering the sample liquid as droplets onto the object by discharging the sample liquid from the nozzle hole.Type: GrantFiled: August 2, 2006Date of Patent: June 14, 2011Assignee: Seiko Epson CorporationInventor: Hiroshi Koeda
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Patent number: 7955863Abstract: Microfluidic devices for manipulating relatively dense materials, such as colloidal rod particles, are provided. Microfluidic devices for separating a denser first material from a less-dense second material are provided. Methods of manipulating a relatively dense first material, for example, colloidal rod particles, and separating the first material from a less-dense second material, are provided. Methods of marking samples or sample components with relatively dense materials, are also provided.Type: GrantFiled: February 11, 2008Date of Patent: June 7, 2011Assignee: Applied Biosystems, LLCInventor: David Cox
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Patent number: 7955556Abstract: An analyzer capable of operating in a normal processing mode performing sequential analysis of a plurality of specimens and in an interrupting mode performing analysis of an urgent specimen that comprising a suction unit for suctioning an urgent specimen, an analysis unit for analyzing an urgent specimen suctioned by the suction unit, an urgent specimen container holder for holding an urgent specimen container containing an urgent specimen, and a moving mechanism for moving the urgent specimen container holder between a placement position at which an urgent specimen container is placed in the holder, and a suction position at which an urgent specimen is suctioned from an urgent specimen container, wherein the moving mechanism comprises a movement force supplying mechanism for supplying a force to move the urgent specimen container holder from the suction position to the placement position is disclosed.Type: GrantFiled: February 23, 2005Date of Patent: June 7, 2011Assignee: Sysmex CorporationInventors: Hiroki Koike, Masayuki Ikeda
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Patent number: 7951329Abstract: A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within the read station, a housing and shield eliminates light leakage from the sample under test. In addition, the read station regulates the intensity of the light by providing an attenuation capability.Type: GrantFiled: March 31, 2004Date of Patent: May 31, 2011Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Ilya Malyarov, Thomas Palmieri
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Patent number: 7947225Abstract: A automated test tube cap removal apparatus includes, a cap remover, a test tube rack which holds a plurality of capped test tubes upright in a row, a clamping mechanism which is disposed in the cap removing position and clamps the plurality of test tubes, and a cap removal unit disposed in the cap removing position and configured to move upward to remove caps from some of a plurality of test tubes and move upward to remove caps from the remaining test tubes. The cap removal unit includes engaging members which are capable of advance and retreat with respect to the caps and clamp each cap, a lift mechanism which raises the engaging members while alternately moving the engaging members upward, thereby removing the cap from each test tube, a cap guide member which separates the cap and guides the cap for dropping.Type: GrantFiled: January 3, 2008Date of Patent: May 24, 2011Assignee: IDS Co., Ltd.Inventor: Teruaki Itoh
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Patent number: 7943100Abstract: The device comprises reaction unit cuvettes for different types of tests, a vertical axis rotor which is associated with a rotation drive means and provided with a horizontal gear-teeth crown delimiting radially outwardly open cavities for receiving the reaction unit cuvettes, a device for supplying the gear-teeth crown with the reaction unit cuvettes, a device for supplying cuvettes with analyzable biological liquid samples, stations arranged around the crown for carrying out measurements and/or analysis and an automation for managing the sequences of a desired process for each cuvette.Type: GrantFiled: April 30, 2010Date of Patent: May 17, 2011Assignees: Immunodiagnostic System FranceInventor: Alain Rousseau
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Patent number: 7939023Abstract: A sensor unit is retained on an assay stage of a surface plasmon resonance (SPR) assay apparatus. The sensor unit includes a prism having a sensing surface, disposed on an upper surface thereof, for detecting reaction of a sample. A flow cell is secured to the upper surface, and has a flow channel for flow of sample fluid containing the sample to the sensing surface. The sensor unit is set removably on the assay apparatus for optically measuring reaction of the sample. In sensor holding, the sensor unit is set on a stage surface of the assay stage by directing down the prism. In a pushing step, a lower surface of the prism is pushed on the stage surface in a first direction upright relative to the stage surface. Two holders push an upper face of the first and second ridges of the prism in the first direction.Type: GrantFiled: March 30, 2007Date of Patent: May 10, 2011Assignee: FUJIFILM CorporationInventor: Yoshiyuki Kunuki
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Patent number: 7939020Abstract: An automatic analyzing apparatus has an analysis section including an immunity analysis unit and a biochemical componential analysis unit. A sample rack which has undergone the immunity componential analysis is horizontally fed by a rack feeding mechanism from a position confronting the inlet of a rack stationing section to a position near the outlet of the rack stationing section, so that the sample rack is directly moved to a return line, while skipping over the rack stationing section, so as to be efficiently returned to the analysis section and subjected to a subsequent biochemical analysis. A sample rack that needs reexamination by an identical analysis unit is also returned in the same efficient way.Type: GrantFiled: May 2, 2007Date of Patent: May 10, 2011Assignee: Hitachi High-Technologies CorporationInventors: Keiko Nogawa, Michiaki Sekiguchi, Hiroshi Watanabe, Hiroaki Ishizawa, Terumi Tamura
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Patent number: 7932090Abstract: Apparatus and methods for positioning the process chambers of microfluidic sample processing devices in the proper focal plane of a microplate reader are disclosed. The apparatus and methods may be adaptable to position the sample processing devices at different heights as may be necessary for processing in different microplate readers. A positioning device is used in connection with the sample processing device to locate the process chambers within the focal plane of the microplate reader.Type: GrantFiled: August 5, 2004Date of Patent: April 26, 2011Assignee: 3M Innovative Properties CompanyInventors: Chad J. Carter, Christopher R. Kokaisel, Kenneth B. Wood
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Patent number: 7927876Abstract: A multiple cuvette strip comprises a plurality of wells and a reversible interlocking device. The well strips can be reversibly interlocked to other well strips to form a sample holder system. One embodiment of a well strip comprises a flange and a slot to form a reversible interlocking device.Type: GrantFiled: April 7, 2010Date of Patent: April 19, 2011Inventors: Matthew R. Blouin, Robert R. Fisette
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Patent number: 7927545Abstract: A container with a rotatable lid for reading and handling diagnostic reagents in tape form comprising a body portion, a lid portion, a continuous tape, a reagent-sensing device, and a storage device. The body portion includes an inner and outer surface. The lid portion is attached to the body portion and is adapted to rotate from a closed position to an open position. The continuous tape includes a diagnostic reagent. The reagent-sensing device is attached to either the body portion or the lid portion and adapted to read the diagnostic reagent. The storage device is attached to the body portion that is adapted to hold and dispense an unused portion of the continuous tape. During the rotation of the lid portion, the continuous tape is advanced from the first storage device and is extended over the reagent-sensing device.Type: GrantFiled: May 27, 2010Date of Patent: April 19, 2011Assignee: Bayer HealthCare LLCInventor: Steven C. Charlton
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Patent number: 7910061Abstract: In a colorimetric absorbance measurement apparatus, a filter assembly on which a plurality of filters are arranged in a circular pattern is continuously rotated by a motor at a regular speed based on a motor drive signal fed from a motor drive circuit, each of the filters being characterized by passing only such light components that have wavelengths falling within a range centering on a specific wavelength. The motor drive signal produced by the motor drive circuit is also fed into a timing generator circuit. The timing generator circuit supplies an A/D conversion start signal to an A/D converter in synchronism with the timing at which a selected one of the multiple filters is positioned on the optical axis of a measuring light beam.Type: GrantFiled: September 20, 2002Date of Patent: March 22, 2011Assignee: Furuno Electric Company, LimitedInventors: Yasuhiro Higuchi, Yoshinori Fujiwara