With Step Of Insertion Or Removal From Test Line Patents (Class 436/48)
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Patent number: 6395554Abstract: A method and apparatus for a slide loading/unloading system is described. A slide storage cassette is provided to store slides in which the slides are stored with an end protruding from the slide storage cassette. A slide feeder is described having grippers, which grip the end of a slide and transport the slide to a sample holder. The sample holder receives and retains the transported slide.Type: GrantFiled: September 3, 1999Date of Patent: May 28, 2002Assignee: Packard Instrument CompanyInventors: Donald T. Regan, Robert T. Milkowski, George Gyorke, Jr., Paul L. St. Cyr, Sean R. Doane
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Patent number: 6387327Abstract: On a base structure (101, 103), an assembly (104) oscillates about a horizontal axis (X—X) between two limit positions; on said assembly, a rotor (106) is capable of rotating about an axis (Y—Y) of rotation orthogonal to said horizontal axis (X—X) and has a ring of seats (121) for test tubes (1); an actuator (145) moves said assembly into a position with the axis of rotation (Y—Y) roughly horizontal, to carry out an agitation stage, and into a position with the axis of rotation (Y—Y) vertical, to carry out, before the reading stage, a centrifugation stage. The ring of seats (121) for test tubes has the test tubes (1) oriented, in the vertical position of said axis of rotation (Y—Y), with their bottom facing downwards and outwards.Type: GrantFiled: November 9, 1998Date of Patent: May 14, 2002Assignee: Diesse Diagnostica Senese S.R.L.Inventors: Antonio Ricci, Francesco Cocola
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Patent number: 6372504Abstract: Conveying of a sample disk method and apparatus for into a reaction vessel is described wherein the sample disk (11) is attached to a tooth (2), where the sample disk is further conveyed to the reaction vessel.Type: GrantFiled: September 24, 1999Date of Patent: April 16, 2002Assignee: Labsystems OyInventors: Jukka Tervamäki, Jukka Tuunanen, Jouko Mikkonen
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Publication number: 20020041830Abstract: This device is directed at filling multiple receptacles without losing integrity of the system. It is also directed at receiving a (sealed) container of receptacles (opened or stopper/closed), opening an access into the sealed container, retrieving receptacles, filling those receptacles, stoppering the receptacles after filling and ejecting the receptacles, either directly into the outside environment or into a closable sack or container, in the latter case while maintaining the integrity of the environment within the device and, if desirable, the sack or closed container.Type: ApplicationFiled: August 2, 2001Publication date: April 11, 2002Inventor: Douglas A. Newberg
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Patent number: 6355488Abstract: A method provides for the placing of samples containers inside holders, a first displacement bringing the holders to an zone with access to the blood analyser pipetting area, identifying the containers during this displacement, a second rectilinear displacement through the pipetting zone along a path perpendicular to the first, a third rectilinear displacement bringing the holders to a second zone acceding to the pipetting area a fourth displacement through the pipetting area and bringing the holders to second outlet zone located on the first path and a path bringing the holder, to the first access zone or an evacuating zone. The method is particularly useful for carrying out hemostasis test on centrifuged blood samples.Type: GrantFiled: August 12, 1999Date of Patent: March 12, 2002Assignee: Diagnostica StagoInventors: Alain Rousseau, Jean-Francois Gelin
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Publication number: 20020012611Abstract: A high throughput chemical screening method uses methods of concurrent transport and/or processing to increase throughput. A screener may concurrently retrieve chemicals from an addressable chemical storage module and deliver chemicals to a liquid handling module. The screener may also use one transport lane for moving chemicals away from a storage module, and a second transport lane for moving chemicals toward the storage module.Type: ApplicationFiled: April 7, 1999Publication date: January 31, 2002Inventors: CHARI STYLLI, SAMUEL S. BECKEY, CHRISTOPHER BENTLY SHUMATE, PETER J. COASSIN
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Patent number: 6337050Abstract: A rack transportation assembly having a projecting member projecting forward is fixed onto a floor by a plurality of adjusters so that its rack transportation surface is brought to a desired level. The projecting member has a first reference surface facing upward. A treatment unit structure having a rack transferring area has a second reference surface in its lower surface. The treatment unit structure is pushed toward the rack transportation assembly under a condition that the second reference surface is lifted upward using height-adjustable casters so as to not become higher than the first reference surface. Then, the treatment unit structure is lowered so that the second reference surface is mounted onto the first reference surface, and a height in the front side of the treatment unit structure is adjusted using the plurality of adjusters.Type: GrantFiled: April 16, 1999Date of Patent: January 8, 2002Assignee: Hitachi, Ltd.Inventors: Katsushi Takahashi, Hitoshi Tokieda, Toshiyuki Ikeda, Susumu Kai
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Patent number: 6333008Abstract: A measuring system and method are provided for performing luminometric series analyses on reaction components to be investigated and the liquid samples containing the magnetizable carrier particles binding the components. Sample chambers receive the liquid samples. These sample chambers are transported to a measuring station on a conveyor. Permanent magnets act on the sample chambers with magnetic fields during transport. A separating station is also provided, which is preferably equipped with a suction and rinsing device to remove the surplus reaction components separated from the carrier particles that accumulate on wall areas of the sample chambers under the influence of the magnetic fields.Type: GrantFiled: September 28, 1999Date of Patent: December 25, 2001Assignee: Stratec Eletronik GnbHInventors: Hermann Leistner, Hans Schiessl
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Patent number: 6319718Abstract: Sample sampling to an analysis apparatus 200 or 820 for analyzing a biochemical analysis item is performed by a pipetting device 202 or 840 which uses a repetitively used pipette nozzle, and sample sampling to an analysis apparatus 100 or 810 for analyzing an immune analysis item is performed by a pipetting device 102 or 830 which uses a disposable nozzle tip. A sample bottle containing a sample to be analyzed on both of a biochemical analysis item and an immune analysis item is sample-pipetted by the nozzle tip first, and then transported so as to be sample-pipetted by the pipette nozzle.Type: GrantFiled: July 26, 1999Date of Patent: November 20, 2001Assignee: Hitachi, Ltd.Inventors: Shigeki Matsubara, Kyoko Imai, Ryuji Tao
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Patent number: 6315952Abstract: An apparatus for drawing and supplying multiple samples for rapid processing in flow cytometry. The apparatus comprises a reciprocating valve and at least one syringe. The invention is also a method for rapidly processing multiple samples in flow cytometry using the apparatus.Type: GrantFiled: June 10, 1999Date of Patent: November 13, 2001Assignee: The University of New MexicoInventors: Larry A. Sklar, Bruce Edwards, Frederick W. Kuckuck, III
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Patent number: 6290907Abstract: A sample handling system comprising: a transportation line including a combination of plural partitive line units; and a plurality of handling units, wherein each of the plural partitive line units and each of the plurality of handling units form a pair, and each handling unit is installed removably from its corresponding partitive line unit. Each handling unit transmits inoperative information to the transportation line when it becomes inoperative. The transportation line transmits this inoperative information to the central controller. The central controller monitors handling units at which the sample rack can stop over. The sample rack avoids stopover at the inoperative handling unit, but is allowed to advance to the subsequent handling unit passing through the partitive line unit which makes a pair with the inoperative handling unit.Type: GrantFiled: September 10, 1998Date of Patent: September 18, 2001Assignee: Hitachi, Ltd.Inventors: Katsushi Takahashi, Mikio Komata, Toshiyuki Ikeda
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Patent number: 6267927Abstract: The apparatus has two main regions of members the operation of which is controlled separately, the first region, to which the user has interactive access, permitting loading of the samples, controls, calibrators, diluents and other equipment for performing the sampling and dilutions and receiving the plate on which the tests are performed, and the second region, to which the user has occasional access, comprising stations dedicated to the rest of the process including incubation, washing, reading, and others, the second region being able to hold several plates at different stages of the process, the apparatus having means for automated movement along three coordinate axes X, Y, Z in order to transport the reagents and the plates in order to complete the process, enabling several tests to be performed at the same time on a set of samples in one or several plates, and enabling new series of tasks with the same or different sets of tests and with the same or different sets of samples to be started when the previType: GrantFiled: November 19, 1998Date of Patent: July 31, 2001Assignee: Grupo Grifols, S.A.Inventors: Pere Pomar Longedo, Xavier Pons Munill, Ivan Twose Valls, Enric Alonso Riera, Carlos Restrepo Guerrero, Francesc Pérez Puigdoménech
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Patent number: 6261521Abstract: A system setup for a sample analysis system having a plurality of analysis units placed along a main conveyor line prior to its analysis operation. The system setup includes setup of analysis units in combination with different types of reagent supply units, setup of analysis routes as to whether it is a stationary type or an automatic type, and setup of analysis items for each analysis unit as to which analysis item should be assigned to which analysis unit having which reagent supply type. These settings are executed through monitoring of setup screens displayed on a screen display unit, and the contents of such a setting are stored and registered in a memory of the controller.Type: GrantFiled: April 7, 1998Date of Patent: July 17, 2001Assignee: Hitachi, Ltd.Inventors: Tomonori Mimura, Ryuichiro Kodama, Atsushi Takahashi, Hiroshi Mitsumaki
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Patent number: 6187267Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.Type: GrantFiled: September 2, 1998Date of Patent: February 13, 2001Assignee: LJL BioSystems, Inc.Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
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Patent number: 6177050Abstract: A container positioning device includes a stop mechanism for stopping a carrier moving along a conveyor, the carrier supporting a container thereon. A pair of arms are pivotally mounted to move between an open position permitting the container to pass along the conveyor track, and a centering position with forward ends in contact with the container and positioning the container in a centering location. A forward end of the downstream arm is operable to move upstream and contact the container to move the container upstream to the centering location, where the second arm will contact the container to retain it in place.Type: GrantFiled: November 18, 1998Date of Patent: January 23, 2001Assignee: LAB-Interlink, Inc.Inventors: Thomas L. Bybee, Inna M. Zevakina
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Patent number: 6162399Abstract: A universal apparatus for clinical analysis is provided comprising a base-board having three main levels. The first level holds a terminal for containers of reagents and samples and includes a device for cyclically vibrating individual vials. External graphic marks on vials and bottles and the internal characteristics of the same, such as the level of contents can be read. The second level of the base-board includes a thermostatic block which is provided with a number of grooves which can receive either disposable strips of small analytical containers or analytical cards. An agglutination reader is also provided. The third level carries a centrifuge which receives either strips or cards from a collection head having a clamp for collecting, conveying and placing in position the strips and cards; the head also including a pipetting needle.Type: GrantFiled: July 23, 1998Date of Patent: December 19, 2000Assignee: Grupo Grifols, S.A.Inventor: Enrique Martinell Gisper-Sauch
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Patent number: 6150173Abstract: The invention relates to an automated device for determining or identifying and measuring a random number of different molecular classes, molecular parts or molecular groups in liquid or solid objects, in particular in cells and tissue specimen, said device comprising a combination of a pipetting system, a 3D handling system and an optical measuring system, preferably a microscope stand including an imaging device.The invention further relates to an automated method for determining or identifying and mapping a random number of molecular classes, molecular parts and molecular groups in objects, with which a random number of different reagent solutions may be applied simultaneously or sequentially to a liquid or solid object, in particular a cell, cells or a tissue specimen, and measured. An important field of application of the invention is cancer research as well as research into the immune system.Type: GrantFiled: July 15, 1999Date of Patent: November 21, 2000Inventor: Walter Schubert
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Patent number: 6146895Abstract: A method of preparing a volatile sample from a material for gas chromatographic analysis includes the steps of: introducing a vial with the material containing the volatile sample and a headspace therein into a chamber of a platen adapted to transport the vial to a location for removal of at least a portion of the volatile sample for gas chromatographic analysis; heating the material containing the volatile sample while the vial is being transported to the location for removal; agitating the vial while in the chamber to enhance a transport rate of the volatile sample from the material to the headspace of the vial; and introducing a needle to the vial to withdraw at least a portion of the volatile sample from the headspace of the vial.Type: GrantFiled: November 9, 1993Date of Patent: November 14, 2000Assignee: Tekmar CompanyInventors: Thomas B. Green, Robert G. Westendorf
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Patent number: 6126901Abstract: An apparatus and method for detecting low levels of one or more radionuclides in a fluid sample uses a substrate that includes an ion exchange resin or other sorbent material to collect the radionuclides. A collecting apparatus includes a collecting chamber that exposes the substrate to a measured amount of the fluid sample such that radionuclides in the fluid sample are collected by the ion exchange resin. A drying apparatus, which can include a drying chamber, then dries the substrate. A measuring apparatus measures emissions from radionuclides collected on the substrate. The substrate is positioned in a measuring chamber proximate to a detector, which provides a signal in response to emissions from the radionuclides. Other analysis methods can be used to detect non-radioactive analytes, which can be collected with other types of sorbent materials.Type: GrantFiled: July 29, 1997Date of Patent: October 3, 2000Assignee: Thermo Power CorporationInventors: Keith D. Patch, Dean T. Morgan
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Patent number: 6117683Abstract: An automated analyzer device has a main conveyance line capable of conveying a sample rack holding a sample, a plurality of analysis units arranged along the main conveyance line, a rack supplying device for supplying the sample rack to the main conveyance line and a rack housing device for housing the sample rack conveyed by the main conveyance line. The automated analyzer includes a controller for confirming that there is no sample rack on the main conveyance line before the main conveyance line receives the sample rack from the rack supplying device. The controller controls operation of the main conveyance line so as to convey the sample rack received from the rack supplying device by the main conveyance line to a position corresponding to a specific one of the plurality of analysis units by which the sample rack is to be received without stopping.Type: GrantFiled: April 8, 1997Date of Patent: September 12, 2000Assignee: Hitachi, Ltd.Inventors: Ryuichiro Kodama, Hiroshi Mitsumaki, Tomonori Mimura, Takayuki Noda
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Patent number: 6117392Abstract: A sample of a sample rack is sampled at analyzing units in the middle of a transfer line. A standby unit and a rack collecting unit are arranged near an exit of the transfer line. After sampling, sample racks are sorted out to the standby unit or the rack collecting unit at a first switching unit. The racks contained in the standby unit are sorted out to a returning line or the rack collecting unit in a second switching unit corresponding to a judged result of whether or not reexamination is required.Type: GrantFiled: July 12, 1999Date of Patent: September 12, 2000Assignee: Hitachi, Ltd.Inventors: Masaaki Hanawa, Hiroshi Mitsumaki, Tadashi Ohishi, Susumu Kai, Hiroshi Watanabe
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Patent number: 6106781Abstract: A processing station is provided for removing a cuvette 1 from a transport magazine 2, for transferring the cuvette to a position for processing in order to carry out a processing step such as adding samples, adding reagents or mixing, and for returning the cuvette to the transport magazine after processing.Type: GrantFiled: October 31, 1997Date of Patent: August 22, 2000Assignee: Roche Diagnostic CorporationInventor: Burkard Rosenberg
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Patent number: 6103193Abstract: An automatic immunoassay method and apparatus which not only permit automatic operations of supplying and discarding reaction tubes, washing for B/F separation, dispensation of reagents, and measurement, but also permit the reaction time to be varied arbitrarily and can cope with any of the assay techniques including one-step and two-step noncompetitive sandwich techniques and competitive techniques.Type: GrantFiled: October 28, 1998Date of Patent: August 15, 2000Assignee: Sanko Junyaku Co., Ltd.Inventors: Kyoichi Iwahashi, Toshimi Kawamura, Eiji Ikeda, Mitsutoshi Sato
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Patent number: 6096561Abstract: Apparatus and method for simultaneously performing at least two assays using certain reagents for a plurality of liquid samples on a continuous analytical system is disclosed. The method comprising the steps of combining an aliquot of each liquid sample with at least one reagent in a first reaction container to form a first assay reaction for each liquid sample, and combining an aliquot of each liquid sample with at least one of the other reagents in a second reaction container to form a second assay reaction for each liquid sample. The method further comprises the steps of incubating the assay reactions of each assay being conducted at least one time, and performing other activities associated with each assay and using the first and second assay reactions to complete each assay, including analyzing the incubated assay reactions.Type: GrantFiled: December 27, 1996Date of Patent: August 1, 2000Assignee: Abbott LaboratoriesInventor: Apparao Tayi
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Patent number: 6086824Abstract: An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles.Type: GrantFiled: June 7, 1999Date of Patent: July 11, 2000Assignee: bioMerieux, Inc.Inventors: Mark Joseph Fanning, Jean-Pierre Bernard Gayral, Roger James Morris, Ron Robinson, William Ernest Seaton, David B. Shine, Paul Springer
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Patent number: 6080363Abstract: A liquid-processing apparatus for processing vital specimens, such as an automatic staining apparatus for staining specimens of vital tissues or the like for microscopic examination, has a cabinet (7) internally provided with a lower plate (8) and an upper plate (9). Rinsing vessels (10) and chemical solution vessels (11) are placed on the lower panel (8), and chemical solution vessels (11) are placed on the upper plate (9). A hanger arm (24) supporting a staining basket (13) containing glass slides carrying specimens affixed thereto moves longitudinally in a lower space (26) extending over the lower plate (8) or an upper space (28) extending over the upper plate (9). The staining basket (13) can be moved between the spaces (26, 28) through a passage (29) formed in the upper plate (9). The liquid-processing apparatus requires a small floor space for installation and can be installed in a small place.Type: GrantFiled: October 14, 1998Date of Patent: June 27, 2000Assignees: Kabushiki Kaisha Tiyoda Seisadusho, Sakura Finetechnical Co. Ltd.Inventors: Tomio Takahashi, Mamoru Wakabayashi, Hiroe Tateya, Norihisa Ishizaka
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Patent number: 6077481Abstract: The automatic pretreatment system for analyzing component of a specimen includes a pouring section for pouring a predetermined solvent into a distribution vial in which the specimen is accommodated, a shaking section for shaking the distribution vial after the solvent is poured, and a distribution section for distributing the specimen liquid in the distribution vial into one or more test vials after shaking. The sending and receiving of the vial between each of the sections, the supply of the test vial into the distribution section, and treatment in each of the sections are carried out automatically.Type: GrantFiled: March 31, 1998Date of Patent: June 20, 2000Assignee: Japan Tobacco, Inc.Inventors: Kaoru Ichida, Yoshikatsu Mori, Takao Tozawa
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Patent number: 6066300Abstract: A vial carrier having plural reagent compartments disposed linearly along the length of the carrier. Each compartment is adapted for receiving one of plural reagent vials. The carrier is provided with indicia uniquely identifying it to an automated assay device. Similarly, each compartment of the carrier has associated with it indicia which are at least unique to the particular carrier. Lastly, each vial installable within a carrier compartment has indicia unique to the contents of the vial. A film seal is applied to the vial opening prior to an integrated cap/seal assembly for the purpose of ensuring that the assembly is liquid-tight. The carrier is configured to be disposed on a slide of an inclining tray within an enclosure. Data reflecting which vial is located in which compartment of a given carrier is collected and provided to the automated instrument prior to installation of the carrier into the enclosure.Type: GrantFiled: June 18, 1998Date of Patent: May 23, 2000Assignee: Bayer CorporationInventors: Glen A. Carey, Scott E. Mathis, David P. Weber
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Patent number: 6060022Abstract: A system for a clinical lab that is capable of automatically processing, including sorting, of multiple specimen containers. The system comprises a central controller, a workstation, one or more analyzers, and an automated centrifuge. The workstation has automatic detectors for detecting the presence of a holder holding specimen containers. The workstation has a bar code reader for reading bar codes on the containers. The system has a transport subsystem, preferably a workstation robotic arm and an analyzer robotic arm for transporting the specimen containers, moving them to and from the workstation, to and from the analyzers, and to and from the centrifuge. The centrifuge is loaded with buckets containing specimen containers. The workstation can be provided with a balance system for balancing the weight of the buckets used. The workstation can also have a decapper for automatically removing caps from the specimen containers.Type: GrantFiled: July 3, 1997Date of Patent: May 9, 2000Assignee: Beckman Coulter, Inc.Inventors: Wing S. Pang, Mark Gross, Hendra Tanumihardja, Ruediger F. Rauskolb, G. Andrea Pedrazzini, Santiago F. Allen
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Patent number: 6043097Abstract: The reagent package includes a container housing section and a container lid that are sealed together to define one or more inside chambers. An opening in the container lid provides access to a corresponding chamber. The chamber opening is controlled by a valve that is pivotable from an open position to a closed position and vice versa. When the valve is in an open position the container chamber can be accessed through the valve with an aspiration probe and a dispensation probe. The reagent package accommodates a filter screen member and a glass ampoule in the container chamber. The glass ampoule contains one reagent ingredient, usually in a dry powder form and the space within the chamber outside the glass ampoule usually contains a reconstituting liquid ingredient.Type: GrantFiled: December 5, 1997Date of Patent: March 28, 2000Assignee: Bayer CorporationInventors: Nicholae Dumitrescu, Andrew Oakes, Randolph Bradshaw, Robert L. Berger, William M. Jameson, Chris Robinson, James R. Laskey
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Patent number: 6027691Abstract: An automatic chemistry analyzer is provided having a high throughput and a high reliability. The analyzer uses nephelometric and turbimetric analyzers to analyze a wide variety of parameters within liquid samples typically generated in, for example, a large medical testing laboratory. The machine employs a unique probe and stirring rod assembly mounted at a slight angle with one another using rack and pinion assemblies so that the lower end of the probe and the lower end of the stirring rod are in very close proximity to one another. This feature allows the machine to be used in unusually small reaction cuvettes. The analysis machine also includes an onboard control sample so that the machine can be programmed to periodically calibrate its analyzing equipment during the course of normal operation.Type: GrantFiled: August 13, 1998Date of Patent: February 22, 2000Assignee: Beckman Coulter, Inc.Inventors: Richard P. Watts, David L. Goodale, Dang M. Ngo, Songai Tu, Michael Tran, Michael L. Bell
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Patent number: 6024921Abstract: Test sample cards containing biological samples are moved through an analytical instrument past a card detection device and detected by the device. The card detection device has an actuator that reciprocates relative to a housing between first and second positions. The actuator has a surface that comes into contact with the card as the card is moved past the device. The actuator carries an optical interrupt flag which is used in conjunction with an optical sensor placed in proximity to the actuator. When the card comes into contact with the actuator, the actuator is moved from the first position to the second, or retracted position. This action moves the flag relative to the optical sensor, triggering the optical sensor and a detection of the card. In one possible embodiment, multiple cards are placed in a cassette for movement around the instrument. The cassette has a number of slots for the cards, one card per slot.Type: GrantFiled: August 25, 1998Date of Patent: February 15, 2000Assignee: bio Merieux, Inc.Inventors: Brent D. Freiner, Ron Robinson, Michael James Justin
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Patent number: 6019945Abstract: A sample analysis system includes blood serum analysis units, blood plasma analysis units and urine analysis units which are arranged along a main conveyor line. The width size of each analysis unit on the side along the main conveyor line is the same. Each analysis unit can be removed integral with a sampling line and its rack transfer device from, the main conveyor line. Removed analysis units can be replaced by each other without changing the entry and exit positions for the sample rack. The conveyor line has the same number of line frame segments as the number of the analysis units.Type: GrantFiled: March 24, 1998Date of Patent: February 1, 2000Assignee: Hitachi Ltd.Inventors: Tadashi Ohishi, Masaaki Hanawa, Susumu Kai, Hiroshi Mitsumaki, Hideyuki Yanami
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Patent number: 6017495Abstract: A staining apparatus for staining of tissue specimens placed on microscope slides comprises a number of staining stations (4) and other working stations (1, 2, 3), where the staining stations (4) receive vessels (5) having liquid baths for receiving baskets containing microscope slides with the topical specimens, and a transport mechanism (17-20) having a hoisting device (17) arranged to be moved over the vessels (5) and to place baskets in or take these up from the vessels, and to transfer the baskets between the working stations (1-4) in accordance with a programme-controlled staining process. The vessels (5) are transparent and are arranged in a number of horizontal rows placed above one another on a stepped base like a tribune, the tribune having a gradient allowing visual inspection of the individual vessels (5) at the working stations (4) from a place of view in front of the apparatus.Type: GrantFiled: May 14, 1998Date of Patent: January 25, 2000Inventor: Torstein Ljungmann
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Patent number: 6001307Abstract: This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together.Type: GrantFiled: April 22, 1997Date of Patent: December 14, 1999Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Michio Naka, Kouji Hirayama, Yoshihiko Higuchi, Masufumi Koike, Hisashi Okuda
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Patent number: 5985215Abstract: In an analyzing apparatus of the present invention, sample racks, in each of which a plurality of sample containers are held, are transferred from a rack feeding unit to a discrimination unit for discriminating a type of each sample container. After the discrimination unit, a plurality of analyzing units are installed along a transfer line, and pipetters of different types are provided in the respective analyzing units. The discrimination unit detects information on the length and the width of each sample container held in each sample rack by using an optical detector. A control part selects one of the analyzing units, suitable for analyzing the sample container of which type was discriminated, based on the information detected by the discrimination unit, and transfers the sample container of which type was discriminated, to a sample pipetting position in the selected analyzing unit.Type: GrantFiled: September 22, 1997Date of Patent: November 16, 1999Assignee: Hitachi, Ltd.Inventors: Taku Sakazume, Hiroshi Mitsumaki, Tomonori Mimura, Kazumitsu Kawase
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Patent number: 5985670Abstract: A method for automatic testing of a laboratory specimen includes the initial step of obtaining a specimen to be tested and placing the specimen in a specimen container. The container is removably mounted in an independent carrier designed to carry an individual specimen through a laboratory to one or more of a plurality of work stations, where a predetermined test will be performed on the specimen. Once the test has been performed, the carrier is moved to another work station based on the result of the first test and then to an archiving station for storage of the specimen.Type: GrantFiled: August 13, 1997Date of Patent: November 16, 1999Assignee: Board of Regents of the University of NebraskaInventor: Rodney S. Markin
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Patent number: 5985672Abstract: A pre-processor for use in performing heterogeneous immunoassays on samples for analytes in the sample employing concentrically positioned incubating and processing carousels. A single transfer station permits reaction vessels containing sample and reagents to be moved between the carousels. The samples are separated, washed and mixed on the processing carousel and incubated on the incubating carousel thus speeding up processing throughput.Type: GrantFiled: January 20, 1998Date of Patent: November 16, 1999Assignee: Dade Behring Inc.Inventors: Joseph Edward Kegelman, John Paul Mizzer, Edward Anthony Nuzzaci, Allan Tit-Shing Chow
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Patent number: 5985671Abstract: A measuring system and method are provided for performing luminometric series analyses on reaction components to be investigated and the liquid samples containing the magnetizable carrier particles binding said components. Sample chambers receive the liquid samples. These sample chambers are transported to a measuring station on a conveyor. Permanent magnets act on the sample chambers with magnetic fields during transport. A separating station is also provided, which is preferably equipped with a suction and rinsing device to remove the surplus reaction components separated from the carrier particles that accumulate on wall areas of the sample chambers under the influence of the magnetic fields.Type: GrantFiled: June 3, 1997Date of Patent: November 16, 1999Assignee: Stratec Elektronik GmbHInventors: Hermann Leistner, Hans Schiessl
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Patent number: 5972295Abstract: A sample of a sample rack is sampled at analyzing units in the middle of a transfer line. A standby unit and a rack collecting unit are arranged near an exit of the transfer line. After sample, sampleracks are sorted out to the standby unit or the rack collecting unit at a first switching unit. The racks contained in the standby unit are sorted out to a returning line or the rack collecting unit in a second switching unit corresponding to a judged result of whether or not reexamination is required.Type: GrantFiled: January 21, 1998Date of Patent: October 26, 1999Assignee: Hitachi, Ltd.Inventors: Masaaki Hanawa, Hiroshi Mitsumaki, Tadashi Ohishi, Susumu Kai, Hiroshi Watanabe
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Patent number: 5968731Abstract: An apparatus for performing automated testing of infections biological specimens is disclosed. The apparatus comprise a process controller for translating user commands into test instrument suite commands, and a test instrument suite comprising a means to treat the specimen to manifest an observable result, and a detector for measuring the observable result to generate specimen test results.Type: GrantFiled: December 10, 1996Date of Patent: October 19, 1999Assignee: The Regents of the University of CaliforniaInventors: Scott P. Layne, Tony J. Beugelsdijk
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Patent number: 5965090Abstract: An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles.Type: GrantFiled: January 13, 1998Date of Patent: October 12, 1999Assignee: bioMerieux, Inc.Inventors: Mark Joseph Fanning, Clifford W. Karl, Donald Meyer, William Ernest Seaton, Paul Springer, Craig Drager
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Patent number: 5955373Abstract: A processing system for processing a plurality of products, the system including a plurality of interchangeable units arranged to receive the products and each having a work station for effecting a specific operation, and a canopy covering said work station, the units being interconnected to form an enclosed chamber encompassing the work stations and covered by the interconnected canopies; an environmental control system for controlling environmental conditions within the chamber; and a transport system for transporting the products within the chamber and between the work stations.Type: GrantFiled: November 5, 1997Date of Patent: September 21, 1999Assignee: Zymark CorporationInventors: Burleigh M. Hutchins, Tye B. Fowler, David R. Friswell, Paul A. Kearsley, Bruce A. Swanson, Eugene T. Tetreault, Jack Elands
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Patent number: 5948360Abstract: A modular vial autosampler has a storage area for vials containing samples to be analyzed and at least one modular sampling station. A vial transfer mechanism includes an arm having a gripper that lifts a sample vial from the storage section, and the arm moves it to a station for identification and then to a sampling station, and under central control activates the sampling station for obtaining a sample for analysis. The vial transfer mechanism gripper is movable in X, Y, and Z directions to capture and move a selected vial and includes an alignment guide for the vials. Potentiometers are used for providing signals indicating arm position and the control is provided with updated information for calibration of the potentiometers and also updated position information for the arm relative to a fixed home position is obtained.Type: GrantFiled: August 29, 1997Date of Patent: September 7, 1999Assignee: Tekmar CompanyInventors: Prabhakar P. Rao, Thomas B. Green, Harry W. Schmidt, Larry J. DaPrato, Greg J. Herman, Michael A. Hill
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Patent number: 5928952Abstract: A processing system for processing a plurality of products, the system including a plurality of interchangeable units arranged to sequentially receive the products and each having a work station for effecting a specific operation on each of the products, the operation requiring a given time period; and wherein each work station accommodates simultaneously a predetermined number of the products, and the given time period and predetermined number associated with each unit are different than the given time periods and predetermined numbers of other said units. A transport system transports the products through the processing system so as to provide for each product a common occupancy time therein.Type: GrantFiled: November 5, 1997Date of Patent: July 27, 1999Assignee: Zymark CorporationInventors: Burleigh M. Hutchins, Tye B. Fowler, David R. Friswell, Paul A. Kearsley, Bruce A. Swanson, Eugene T. Tetreault, Jack Elands
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Patent number: 5925514Abstract: An apparatus for testing specimens for infection by a retrovirus is described. The apparatus comprises a process controller including a communications module for translating user commands into test instrument suite commands and a means for communicating specimen test results to a user. The apparatus further comprises a test instrument suite including a means for treating the specimen to manifest an observable result and a detector for measuring the observable result.Type: GrantFiled: December 10, 1996Date of Patent: July 20, 1999Assignee: The Regents of the University of CaliforniaInventors: Scott P. Layne, Tony J. Beugelsdijk
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Patent number: 5904899Abstract: An apparatus has a holder unit for sample vessels and reaction vessels, a dispensing unit and a washing unit; wherein, (i) the holder unit involves a sample-vessel holder including a linear array of holes for receiving the sample vessels, a reaction-vessel holder including a linear array of holes for receiving the reaction vessels, a coupling arrangement for coupling together the sample-vessel holder and the reaction-vessel holder so that the linear arrays of the holes of the holders are arranged parallel to each other, and a moving arrangement for horizontally moving the coupled sample-vessel holder and the reaction-vessel holder, (ii) the dispensing unit is movable in the direction orthogonal to the horizontal-moving direction of the sample-vessel holder and the reaction-vessel holder, and (iii) the washing unit supplies cleaning liquid to the reaction vessels and absorbs the liquid-phase component from the reaction vessels.Type: GrantFiled: May 15, 1998Date of Patent: May 18, 1999Assignee: Tosoh CorporationInventor: Hidechika Hayashi
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Patent number: 5902549Abstract: A plurality of analyzer units for serum, a plurality of analyzer units for blood plasma, and a plurality of analyzer units for urine are arranged along a main transfer line for transferring a sample rack from a rack providing portion to a rack storage portion. A reagent bottle for inspecting liver function is contained in each reagent delivery mechanism of two analyzer units among the plurality of analyzer units for serum. When the reagent for inspecting liver function in one of the two analyzer units is to be short, analysis for the liver function analysis item in the samples can be continued by transferring a sample rack from the rack providing portion to the other analyzer unit.Type: GrantFiled: March 7, 1997Date of Patent: May 11, 1999Assignee: Hitachi, Ltd.Inventors: Tomonori Mimura, Hiroshi Mitsumaki, Tadashi Ohishi, Taku Sakazume
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Patent number: 5897835Abstract: A positioning system for a sample testing machine incudes a base pan and a set of independent drive systems for sliding a sample tray across the base pan. Each of the drive systems incudes a paddle that engages a side of the sample tray. The paddle is slideably mounted to a shaft with a collar that slides over the shaft. A motor and drive belt is provided to move the collar along the shaft, causing the paddle to engage the side of the sample tray and slide the sample tray across the base pan. Track sections are provided in the base pan to prevent the sample tray from rotating as the paddle slides the sample tray across the base pan.Type: GrantFiled: March 14, 1997Date of Patent: April 27, 1999Assignee: bioMerieux Vitek, Inc.Inventors: William Ernest Seaton, Mark Joseph Fanning, JoAnne T. Gerst
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Patent number: RE37194Abstract: A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels.Type: GrantFiled: May 9, 2000Date of Patent: May 29, 2001Assignee: Pharmacopeia, Inc.Inventors: Gregory L. Kirk, Robert H. Grubbs