Saccharide (e.g., Dna, Etc.) Patents (Class 436/94)
Glucose (Class 436/95)
  • NON-INVASIVE IN VITRO METHOD FOR QUANTIFYING LIVER LESIONS
    Publication number: 20110313276
    Abstract: An in-vitro non-invasive method for quantifying the lesions of the liver of the patient with metabolic steatosis addressing a diagnostic target, i.e. fibrosis, steatosis and/or steato-hepatitis (NASH) and measuring at least one marker selected from the group consisting of biomarkers and possibly clinical markers and possibly scores, the biomarkers being selected from the group consisting of glycemia, AST (aspartate aminotransferase), ALT (alanine aminotransferase), AST/ALT, AST.
    Type: Application
    Filed: November 18, 2009
    Publication date: December 22, 2011
    Applicants: CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS, UNIVERSITE D'ANGERS
    Inventors: Paul Cales, Christophe Aube, Vincent Roullier
  • DNA AND PROTEINS OR PEPTIDES SPECIFIC OF BACTERIA OF THE NEISSERIA MENINGITIDIS SPECIES, METHODS FOR OBTAINING THEM AND BIOLOGICAL APPLICATIONS THEREOF
    Publication number: 20110313026
    Abstract: The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp C, opc, por A, rotamase the sequence IC1106, IgA protease, pilline, pilC, transferrin binding proteins and opacity proteins. The invention also concerns the polypeptides corresponding to these DNA and the antibodies directed against these polypeptides. It is applicable in the prevention and the detection of meningococcus induced infections and meningitis.
    Type: Application
    Filed: January 20, 2011
    Publication date: December 22, 2011
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Xavier NASSIF, Colin Tinsley
  • POLYMER END GROUP DETECTION
    Publication number: 20110311988
    Abstract: Provided herein are processes of detecting and quantifying the number of polymer end groups in a sample. In particular instances provided herein are processes of detecting.
    Type: Application
    Filed: December 31, 2009
    Publication date: December 22, 2011
    Applicant: ZACHARON PHARMACEUTICALS, INC.
    Inventors: Brett E. Crawford, Jillian R. Brown, Charles A. Glass
  • OPTIMIZED PPROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION, SCREENING, ISOLATING AND SEQUENCING OF MRSA, MSSA STAPHYLOCOCCUS MARKERS, AND THE ANTIBIOTIC RESISTANCE GENE MEC A
    Publication number: 20110306510
    Abstract: Described herein are primers and probes useful for the detection, screening, isolation and sequencing of MRSA, MSSA, Staphylococci markers, and the antibiotic resistance gene mecA.
    Type: Application
    Filed: September 3, 2010
    Publication date: December 15, 2011
    Applicant: Intelligent Medical Devices, Inc.
    Inventors: Heinz R. Reiske, Chunyang Zheng, David L. Dolinger, Alice A. Jacobs, Philip T. Moen, Chesley Leslin, Juan Manuel Anzola, James R. Hully
  • Apparatus for single-molecule detection
    Publication number: 20110306143
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Application
    Filed: July 29, 2010
    Publication date: December 15, 2011
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
    Patent number: 8076149
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: December 13, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • EXPONENTIAL ISOTHERMAL SELF-SUSTAINED REPLICATION OF AN RNA ENZYME
    Publication number: 20110300554
    Abstract: This invention provides nucleic acid molecules that catalyze their own replication and undergo exponential amplification at a constant temperature and in the absence of proteins or other biological components, such as those employed in other amplification reactions, e.g., proteins including DNA or RNA polymerase and a method of detect a selected molecule using said nucleic acid.
    Type: Application
    Filed: December 31, 2009
    Publication date: December 8, 2011
    Inventors: Gerald F. Joyce, Bianca J. Lam
  • METHOD FOR DETERMINING REDOX ACTIVITY AND SCREENING COMPOUNDS BASED ON REDOX ACTIVITY
    Publication number: 20110300567
    Abstract: A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.
    Type: Application
    Filed: August 9, 2011
    Publication date: December 8, 2011
    Inventors: Jonathan J. Abramson, Benjamin S. Marinov
  • METHODS FOR PREPARATION OF ZnTe NANOCRYSTALS
    Publication number: 20110300076
    Abstract: Nanocrystals having a ZnTe core and methods for making and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide quantum yields and stability suitable for applications such as flow cytometry, cellular imaging, and protein blotting, medical imaging, and other applications where cadmium toxicity is an issue.
    Type: Application
    Filed: October 2, 2009
    Publication date: December 8, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Eric Tulsky, Joseph Bartel, Joseph Treadway
  • Compositions and methods for biodetection by nucleic acid-templated chemistry
    Patent number: 8071388
    Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: December 6, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Yumei Huang, James M. Coull
  • WATER SOLUBLE FLUORESCENT COMPOUNDS
    Publication number: 20110294118
    Abstract: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.
    Type: Application
    Filed: November 29, 2010
    Publication date: December 1, 2011
    Applicant: BIOSEARCH TECHNOLOGIES, INC.
    Inventor: MARK REDDINGTON
  • NUCLEIC ACID SEQUENCING DEVICE AND METHOD OF DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID USING THE SAME
    Publication number: 20110294117
    Abstract: A nucleic acid sequencing device includes at least one nanochannel, a first electrode and a second electrode disposed at opposite ends of the nanochannel for applying a voltage in the lengthwise direction of the nanochannel, and a first detector that detects a location signal of a target nucleic acid passing through the nanochannel and a second detector that detects a signal from a detectable label bound to the target nucleic acid.
    Type: Application
    Filed: November 24, 2010
    Publication date: December 1, 2011
    Applicant: SAMSUNG ELECTRONICS CO., LTD
    Inventors: Suhyeon KIM, Joo-won RHEE
  • ANALYSIS OF SULFATED POLYSACCHRIDES
    Publication number: 20110288046
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 24, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: GANESH VENKATARAMAN, ZACHARY SHRIVER, MALIKARJUN SUNDARAM, YI-WEI QI, RAM SASISEKHARAN
  • Method for continuously monitoring solution-phase synthesis of oligonucleotide
    Publication number: 20110287550
    Abstract: The present invention provides a system and method for real-time continuously monitoring of oligonucleotide synthesis in solution phase.
    Type: Application
    Filed: May 24, 2011
    Publication date: November 24, 2011
    Applicants: National Sun Yat-Sen University, ScinoPharm Taiwan, Ltd.
    Inventors: Jentaie Shiea, Chu-Nian Cheng
  • CHARACTERIZATION OF O-LINKED GLYCANS
    Publication number: 20110287465
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
    Type: Application
    Filed: December 18, 2009
    Publication date: November 24, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Cuihua Liu, Xiao-Jin Xu, Shiming Dong, Guy Dellorusso
  • Kit for measuring in vivo mutation frequency at an endogenous gene locus
    Patent number: 8062860
    Abstract: The present invention relates a method for the enumeration of in vivo gene mutation. The method utilizes differential staining of GPI-anchor deficient erythrocyte populations to distinguish between wild-type and pig-a gene mutants. Quantitative analyses can be conducted on erythrocytes and/or reticulocytes, and is based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of mutant erythrocytes or reticulocytes relative to the number of total erythrocytes or reticulocytes can be used to assess the DNA-damaging potential of an exogenous chemical agent, the DNA-damaging potential of an exogenous physical agent, the effects of an exogenous agent which can modify endogenously-induced DNA damage, and the effects of an exogenous agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: November 22, 2011
    Assignee: Litron Laboratories, Ltd.
    Inventor: Stephen D. Dertinger
  • Diagnostic histopathology using multiplex gene expression FISH
    Patent number: 8062897
    Abstract: The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be detected simultaneously using between 8 and 82 probes for each nascent RNA. The invention comprises, in addition, methods of preparing a sample for nascent RNA detection by reducing autofluorescence of the tissue sample. These techniques may be synergistically combined to achieve significantly improved results.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 22, 2011
    Assignee: Aureon Laboratories, Inc.
    Inventors: Paola Capodieci, Michael J. Donovan
  • NANOPARTICLE DERIVATIZATION OF TARGETS FOR DETECTING AND DETERMINING THE CONCENTRATIONS OF TARGETS BY IMPEADANCE-SPECTROSCOPY-BASED SENSORS
    Publication number: 20110281368
    Abstract: Embodiments of the present invention are directed to for detecting the presence and concentration of one or more particular target molecules in solutions, air or other gasses, or otherwise present in an environment or sample, by impedance-spectroscopy-based sensors. Various embodiments of the present invention provide for derivatizing target molecules with nanoparticles to increase capacitance changes at electrode surfaces in order to generate stronger signals and improve signal-to-noise ratios of impedance-spectroscopy-based sensors.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 17, 2011
    Inventors: Andrei L. Gindilis, Kevin Robert Schwarzkopf, Paul J. Schuele, Mark Albert Crowder
  • ANALYSIS OF MYCOPHENOLIC ACID IN SALIVA USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY
    Publication number: 20110281369
    Abstract: A method for mass spectrometric analysis of a saliva sample possibly containing mycophenolic acid or its metabolites mycophenolic acid phenyl glucuronide (MPAG) or mycophenolic acid acyl-glucuronide (Acyl-MPAG), including the steps: (a) providing a saliva sample containing one or more drug or metabolites; (b) deproteinating the sample; (c) separating the one or more drug or metabolites from the saliva sample; and (d) analyzing the one or more drug or metabolites using a mass spectrometer. The sample containing one or more MPA or metabolites is obtained from in an oral fluid based biological samples i.e. whole saliva or saliva obtained by chemical or mechanical stimulation or from specific salivary glands. The size of the sample contains one or more MPA or metabolites is at least about 100 microL.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 17, 2011
    Applicant: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
    Inventors: Fatemeh Akhlaghi, Anisha E. Mendonza
  • In-vitro method for testing bioequivalence of iron-sucrose formulation
    Patent number: 8058076
    Abstract: The present disclosure relates to an in vitro method for measuring the T75 of reduction kinetics of iron from Fe+3 to Fe+2 in an iron-sucrose complex and hence assessing the bioequivalency of iron-sucrose composition. According to the disclosed method, T75 of reduction kinetics of iron in an iron-sucrose complex in between 25 to 50 minutes indicates bioequivalent iron-sucrose composition.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: November 15, 2011
    Assignee: Astron Research Limited
    Inventors: Samir Shah, Keyur Patel, Sanjay Dash, Kuldeep Dilip Karnik, Ashish Sehgal, Bhavesh Vallabhabhai Patel, Jayanta Kumar Mandal
  • Monitoring velocities in a polymerization process
    Patent number: 8059264
    Abstract: Method for monitoring the velocity of growing polymer particles flowing in a two-phase stream during a polymerization process, said method comprising measuring the degree of attenuation in the propagation of light in said two-phase stream by means of a photometric instrument, said photometric instrument comprising: one or more transmitting optical waveguides connecting one or more light sources to said two-phase stream, one or more receiving optical waveguides connecting said two-phase stream to a light detector.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: November 15, 2011
    Assignee: Basell Poliolefine Italia, s.r.l.
    Inventors: Christian Ulrich Schmidt, Stefan Ziegler, Gabriele Mei, Stefano Bertolini, Gerben Meier
  • LANTHIONINE SYNTHETASE COMPONENT C-LIKE PROTEINS AS MOLECULAR TARGETS FOR PREVENTING AND TREATING DISEASES AND DISORDERS
    Publication number: 20110275558
    Abstract: The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs.
    Type: Application
    Filed: May 4, 2011
    Publication date: November 10, 2011
    Applicant: Virginia Tech Intellectual Properties, Inc.
    Inventors: Josep BASSAGANYA-RIERA, Pinyi LU, Raquel HONTECILLAS
  • METHOD FOR RELEASING REDUCING GLYCAN BY AMMONIUM SALT
    Publication number: 20110275108
    Abstract: An objective of the present invention is to provide a glycan releasing method which can be applied to construction of a system for automation of glycan analysis, and particularly a glycan releasing method capable of analyzing an O-linked glycan. The objective could be achieved as a result of finding that the pH is lowered by using an ammonium salt or ammonium ion in the absence of concentrated aqueous ammonia, not using concentrated aqueous ammonia, thus drastically avoiding an undesired side reaction such as a peeling reaction or the like.
    Type: Application
    Filed: August 11, 2009
    Publication date: November 10, 2011
    Applicant: National University Corporation Hokkaido Universit
    Inventors: Shin-Ichiro Nishimura, Yoshiaki Miura
  • MAGNETIC NANOSENSOR COMPOSITIONS AND BIOANALYTICAL ASSAYS THEREFOR
    Publication number: 20110275985
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Application
    Filed: July 2, 2009
    Publication date: November 10, 2011
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, JR., James J. Koziarz, Douglas A. Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
  • MARKER FOR GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER
    Publication number: 20110269123
    Abstract: In embodiments the expression or methylation of the PAX5 gene is used as a marker for the diagnosis and prognosis of gastric cancer. In further embodiments methods for detecting gastric cancer are disclosed as are methods for inhibiting the growth of gastric cancer.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 3, 2011
    Applicant: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung, Xiaoxing Li
  • TARGET PROTEIN AND TARGET GENE FOR DRUG DISCOVERY, AND SCREENING METHOD
    Publication number: 20110269141
    Abstract: The problems of the present invention are to provide target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. The present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
    Type: Application
    Filed: February 20, 2008
    Publication date: November 3, 2011
    Applicant: REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD.
    Inventors: Katsuhisa Murayama, Tadakazu Yamauchi, Kouichi Tsuchiya, Kazuo Komiya, Morikazu Kito, Yuko Isono, Noriyuki Inomata, Yorimasa Suwa, Ai Wakamatsu, Junichi Yamamoto, Takao Isogai
  • Holographic sensor
    Patent number: 8048680
    Abstract: A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: November 1, 2011
    Assignees: Smart Holograms Limited, Cambridge Enterprise Ltd.
    Inventors: Christopher Robin Lowe, Jeffrey Blyth, Satyamoorthy Kabilan, Abid Hussain, Xiaoping Yang, Felicity Kate Sartain, Mei-Ching Lee
  • MODIFIED NUCLEOTIDES
    Publication number: 20110262917
    Abstract: Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays.
    Type: Application
    Filed: April 20, 2011
    Publication date: October 27, 2011
    Applicant: PIERCE BIOTECHNOLOGY, INC.
    Inventors: Kay Opperman, Barbara J. Kaboord, Jean-Samuel Schultz, Christopher L. Etienne, Greg Hermanson
  • METHOD FOR PRETREATING SPECIMEN AND METHOD FOR ASSAYING BIOLOGICAL SUBSTANCE
    Publication number: 20110262919
    Abstract: On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet comes close to the pipette chip. While remotely constraining with the magnet the magnetic particles carrying the nonspecific reaction factor bonded thereto, the residual liquid is discharged into a well. Thus, the removal of a contaminant contained in the specimen is completed. The thus treated specimen discharged into the well is subjected to an immunoassay. The magnetic particles carrying the antibody immobilized thereon are mixed with the treated specimen and suspended therein. The suspension is sucked up into a pipette chip and the magnetic particles carrying an antigen bonded thereto are separated by use of the magnet.
    Type: Application
    Filed: December 25, 2009
    Publication date: October 27, 2011
    Inventor: Hideji Tajima
  • STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES
    Publication number: 20110262485
    Abstract: Novel molecules termed STING which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a subject.
    Type: Application
    Filed: August 4, 2009
    Publication date: October 27, 2011
    Applicant: University of Miami
    Inventor: Glen N. Barber
  • SYSTEM AND METHOD FOR MULTI-ANALYTE DETECTION
    Publication number: 20110262896
    Abstract: The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials therebetween. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector.
    Type: Application
    Filed: April 26, 2011
    Publication date: October 27, 2011
    Inventors: Lawrence Blecka, Larry Seamer, Sachi Rastogi, Chris Tsai, Nasser Jafari, Ken J. Lafredo
  • Fluorescence based biosensor
    Patent number: 8043802
    Abstract: A novel biosensor comprises at least one fluorophore and at least two quenchers, and is capable of selectively and specifically detecting the presence of an ion in the presence of other ions.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: October 25, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Yi Lu, Juewen Liu
  • LC-MFR-MS-Based Method and Apparatus for Screening a New Drug Candidate
    Publication number: 20110256580
    Abstract: The present invention relates to a method for screening a new drug candidate using a liquid chromatography/microfluidic device/mass spectrometry system, and to a liquid chromatography/microfluidic device/mass spectrometry system. The present invention involves the detection of an interaction between molecules on a real-time basis through adjustment of a microreaction between traces of natural material or synthesized new drug candidates and a target material (protein or cell, etc.), thus developing materials for new drug candidates at a lower cost and with high efficiency, while improving quality of life and reducing medical costs. The present invention can be valuably used in increasing new scientific technology through the convergence of nanotechnology, biotechnology, and analytical chemistry technology.
    Type: Application
    Filed: December 16, 2009
    Publication date: October 20, 2011
    Applicant: KOREA BASIC SCIENCE INSTITUTE
    Inventors: Sanggoo Kim, Jin-Woo Jung, Chan-Soo Park
  • METHODS AND PROCESSES FOR CALLING BASES IN SEQUENCE BY INCORPORATION METHODS
    Publication number: 20110256631
    Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
    Type: Application
    Filed: February 24, 2011
    Publication date: October 20, 2011
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Austin Tomaney, Kenneth Mark Maxham, David Holden, Kevin Hester, Devon Murphy, Patrick Marks
  • Fluorescent Dye Compounds, Conjugates and Uses Thereof
    Publication number: 20110250699
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Ronald J. Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
  • NON-NATURALLY OCCURRING DNA SEQUENCES
    Publication number: 20110250697
    Abstract: DNA compositions having nucleotide sequences that do not occur in nature. Also provided are fluorescently labeled DNA molecules and complementary DNA on solid substrates, such as microspheres.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 13, 2011
    Applicant: ILLUMINA, INC.
    Inventors: Jerzy Kakol, Tobias Mann, Timothy K. McDaniel
  • METHODS OF NUCLEIC ACID TARGET CAPTURE
    Publication number: 20110250698
    Abstract: Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a short time, are disclosed. Compositions that include a capture probe that specifically binds to a target nucleic acid and a denaturant chemical, which when mixed with the target nucleic acid and incubated at elevated temperature for a short time, promote efficient hybridization of the capture probe and target nucleic acid are disclosed.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 13, 2011
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Reinhold B. POLLNER, Michael M. Becker, Mehrdad R. Majlessi
  • Bisulfite Conversion of DNA
    Publication number: 20110250601
    Abstract: The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surprisingly efficacious methods for bisulfite conversion of DNA relative to prior art methods. The converted DNA may subsequently be analyzed by many different methods.
    Type: Application
    Filed: June 13, 2011
    Publication date: October 13, 2011
    Applicant: Epigenomics AG
    Inventors: Kurt Berlin, Matthias Ballhause, Karen Cardon
  • PROGNOSTIC AND DIAGNOSTIC METHOD FOR CANCER THERAPY
    Publication number: 20110251087
    Abstract: The present invention relates to methods for the diagnosis and prognosis of aggressive forms of cancer using a combination of gene expression signatures.
    Type: Application
    Filed: January 28, 2011
    Publication date: October 13, 2011
    Inventor: Gennadi V. Glinsky
  • Photolabile compound, oligomer probe array and substrate for oligomer probe array containing the same, and manufacturing method of the same
    Patent number: 8034747
    Abstract: A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: October 11, 2011
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sung-min Chi, Jung-hwan Hah, Kyoung-seon Kim, Won-sun Kim, Man-hyoung Ryoo
  • METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY
    Publication number: 20110243956
    Abstract: Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that alter soluble endoglin levels or biological activity.
    Type: Application
    Filed: April 27, 2011
    Publication date: October 6, 2011
    Applicant: Beth Israel Deaconess Medical Center
    Inventors: S. Ananth Karumanchi, Vikas Sukhatme
  • Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
    Patent number: 8030031
    Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: October 4, 2011
    Assignee: OncoMedx, Inc.
    Inventor: Michael Kopreski
  • MARKER FOR DIAGNOSIS OF EXPOSURE TO ELECTROMAGNETIC RADIATION AND DIAGNOSTIC KIT COMPRISING THE SAME
    Publication number: 20110237454
    Abstract: Disclosed are a composition for the diagnosis of exposure to electromagnetic radiation, comprising an agent capable of measuring the expression level of the diagnostic marker, a diagnosis kit comprising the same, a method for detecting the diagnostic marker, and a method for the diagnosis of exposure to electromagnetic radiation. The diagnostic markers are very useful for monitoring and diagnosing exposure to electromagnetic fields, and can be used as instruments by which physiological mechanisms incurred upon electromagnetic radiation exposure are examined.
    Type: Application
    Filed: February 24, 2011
    Publication date: September 29, 2011
    Applicants: SNU R&DB FOUNDATION, ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Woong Yang Park, Ae Kyung Park, Chang Nim Im, Sook Ik Jeon
  • SINGLE MOLECULE DETECTION AND SEQUENCING USING FLUORESCENCE LIFETIME IMAGING
    Publication number: 20110236983
    Abstract: A nucleic acid detection system and method are provided, in which excitation energy is transmitted from a pulsed excitation source to a reaction site including a fluorescence resonance energy transfer (FRET)-based dye system to generate a fluorescent signal at the reaction site, the fluorescent signal is detected by a detector from the reaction site, and detection of the fluorescent signal is respectively blocked and permitted at the detector by a detector gate this is timed based on an emission start time of the transmitted excitation energy.
    Type: Application
    Filed: December 29, 2010
    Publication date: September 29, 2011
    Inventors: Joseph Beechem, Theofilos Kotseroglou, William Michael Lafferty, Mark F. Oldham
  • TREATMENT OF SIRTUIN 1 (SIRT1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SIRTUIN 1
    Publication number: 20110237649
    Abstract: Oligonucleotide compounds modulate expression and/or function of Sirtuin 1 (SIRT1) polynucleotides and encoded products thereof. Methods for treating diseases associated with Sirtuin 1 (SIRT1) comprise administering one or more Oligonucleotide compounds designed to inhibit the SIRT1 natural antisense transcript to patients.
    Type: Application
    Filed: December 2, 2009
    Publication date: September 29, 2011
    Applicant: OPKO CuRNA, LLC
    Inventors: Joseph Collard, Olga Khorkova Sherman, Carlos Coito, Belinda De Leon
  • Genetic Alterations on Chromosomes 21q, 6q and 15q and Methods of Use Thereof for the Diagnosis and Treatment of Type I Diabetes
    Publication number: 20110236370
    Abstract: Compositions and methods for the detection and treatment of T1D are provided.
    Type: Application
    Filed: November 16, 2010
    Publication date: September 29, 2011
    Inventors: Hakon Hakonarson, Struan Grant, Jonathan Bradfield, Constantin Polychronakos, Hui-Qi Qu
  • ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES
    Publication number: 20110236982
    Abstract: Embodiments of this invention relate to the analysis of mass spectral data in the quiet zones.
    Type: Application
    Filed: December 14, 2010
    Publication date: September 29, 2011
    Applicant: DH Technologies Development PTE, LTD.
    Inventor: Darryl J.C. Pappin
  • Aptamer-Based Colorimetric Sensor Systems
    Publication number: 20110236991
    Abstract: The present invention provides an aptamer-based colorimetric sensor system for determining the presence and optionally the concentration of an analyte in a sample. Methods of utilizing the sensor system and kits that include the sensor also are provided. The sensor utilizes a linker and oligonucleotide functionalized particles to form an aggregate, which disaggregates in response to the analyte.
    Type: Application
    Filed: January 18, 2011
    Publication date: September 29, 2011
    Inventors: Yi Lu, Juewen Liu
  • BIOMARKERS FOR DRUG-INDUCED ELONGATED QT INTERVAL AND TORSADES DE POINTES
    Publication number: 20110237456
    Abstract: The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly drug-induced prolonged QT interval or TdP. The invention also provides a method of identifying a subject afflicted with, or at risk of, developing TdP. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing TdP.
    Type: Application
    Filed: March 24, 2011
    Publication date: September 29, 2011
    Inventors: Aris FLORATOS, Matthew R. NELSON, Sally L. JOHN
  • MARKER FOR DIAGNOSIS OF EXPOSURE TO ELECTROMAGNETIC RADIATION AND DIAGNOSTIC KIT COMPRISING THE SAME
    Publication number: 20110237452
    Abstract: Disclosed are a composition for the diagnosis of exposure to electromagnetic radiation, comprising an agent capable of measuring the expression level of the diagnostic marker, a diagnosis kit comprising the same, a method for detecting the diagnostic marker, and a method for the diagnosis of exposure to electromagnetic radiation. The diagnostic markers are very useful for monitoring and diagnosing exposure to electromagnetic fields, and can be used as instruments by which physiological mechanisms incurred upon electromagnetic radiation exposure are examined.
    Type: Application
    Filed: February 24, 2011
    Publication date: September 29, 2011
    Applicants: SNU R&DB FOUNDATION, ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Woong Yang Park, Ae Kyung Park, Chang Nim Im, Sook Ik Jeon