Abstract: Chronic uremic patients undergoing periodical dialysis are treated with carnitine or one of its salts to prevent or treat carnitine deficiency in patients with end stage renal disease. An effective dose of carnitine, preferably L-carnitine fumarate, is administered preferably intravenously into the venous return line after each dialysis session.

Abstract: A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.

Abstract: Exogenous L-carnitine in the form of an equimolar amount of L-carnitine acid fumarate is administered to reduce increased volume and fluidity of stools and frequency of bowel movements relative to their usual pattern brought about by the administration of exogenous L-carnitine. Preferably nutritionally dietetically or therapeutically effective amount of L-carnitine acid fumarate is administered orally in the form of a tablet pill, capsule or powder.

Abstract: Cosmetic/dermatological compositions, well suited, e.g., for skin-firming and anti-aging applications, as well as for stimulating the proliferation of dermal fibroblasts, comprise effective skin affliction-alleviating amounts of (a) at least one hydroxystilbene compound, in immixture with (b) at least one ascorbic acid compound, advantageously formulated into a topically applicable, physiologically/cosmetically acceptable vehicle, diluent or carrier therefor.

Abstract: An herbal formulation comprises betaine HCl, plant enzymes, papain, probiotic micro flora, fruitooligosaccharides, l-glutamine, quercitin, butyric acid, borage seed, flax seed, lecithin, gamma oryzanol, bromelain, pepsin, and N-acetylglucosamine.

Abstract: A method of treating carbohydrate craving in a human patient comprises administering to the patient an anorexigenic composition comprising a compound which elevates serotonin levels in the brain of the patient, typically hypercin, found in St John's Wort Extract, or sibutramine, in a mixture with a physiologically acceptable metabolisable chromium compound. The chromium compound is selected from chromium picolinate, chromium polynicotinate, chromium chelate, chromium proteinate, or any other bioavailable chromium compound. The mixture optionally includes laevorotary carnitine or a racemic mixture of carnitine.

Abstract: A novel powder composition comprised of a skin irritation reducing agent comprising 1-Carboxy-N,N,N-trimethylmethanaminium hydroxide inner salt, scutellaria baicalensis extract, bisabolol, or mixtures thereof. Also provided is a method for treating prickly heat comprised of topically applying an effective amount of the powder to a desired area.

Abstract: Aqueous shampoo compositions whose washing base consists of an anionic surfactant and an amphoteric surfactant, in which some of the amphoteric agent consists of undecylenamidopropylbetaine, are described. This amphoteric principle gives these compositions effective antifungal properties against the action of Pityrosporum ovalae and constitutes a treatment for reducing the formation of dandruff.

Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group including neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigmeninal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, anthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs clinical syndromes of reduced height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiences and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group including L-acetylcarnitine, L-isovalerylcarn

Abstract: A cosmetic or dermatological topical preparation contains, as active ingredient, an &agr;-amino acid derivative of the formula (I) 1

Abstract: A composition containing the active ingredients acetyl L-carnitine and &agr;-lipoic acid for the prevention and/or therapeutic treatment of various alterations and pathological states induced by free radicals, that may be in the form of a dietary supplement, dietetic support or of an actual medicine.

Abstract: A hair growth formulation. The two basic main ingredients are castor oil and a special lemon extract. The special lemon extract is made from fresh lemon peel. The peel, including the bioflavonoids membrane, is blended with purified water until it is liquidified. Then the mixture is filtered through a sanitized cloth. Other ingredients that have been found helpful include: inositol, choline (from bitartate), niacinamide or nicotinic acid, manganese in chelated form, bioflavonoids, and folic acid. Finally perfume and sodium benzoate (as a preservative) can be added.

Abstract: A method for treating celiac disease comprising administration of a composition containing an alkanoyl L-carnitine wherein the alkanoyl group is straight or branched and has 2-6 carbon atoms and the pharmacologically acceptable salts thereof.

Abstract: A method for obtaining an oil that is rich in hydroxyoctadecadienoic(HODE) fatty acids or the esters thereof. According to the inventive method, controlled oxidation of the linoleic acid and/or the linolenic acid or the esters thereof is performed in the presence of an oxidation catalyst. The oxidation is terminated when the HODE content or total ester content is more than 5 % and/or the 9-hydroxy-10,12-octadecadienoic(9-HODE) acid isomer or ester content is more than 1.5 % and reduction occurs for the hydroperoxides formed during the oxidation reaction by a reducer. The invention can be used as a medicament, food supplement or cosmetic.

Abstract: This invention relates to a composition of acetyl-L-carnitine in combination with hypericin and/or Hypericum extract (Hypericum perforatum L. (St. John's Wort)) in synergistically effective amounts. The composition is effective at treating a nervous alteration due to an anxiety state, irritability, or depression.

Abstract: Use of Carnitine for achieving or enhancing training-induced bradycardia in a mammal, particularly in a horse, most preferably in a trotter horse.

Abstract: Solid and non hygroscopic salts consisting of lower alkanoyl L-carnitine magnesium citrates are disclosed which are suitable for preparing solid composition useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.

Abstract: Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-&agr;-lipoic acid are administered. Optionally, coenzyme Q and/or creatine also are administered. Preferably 10 mg to 500 mg/day of coenzyme Q10 and 1 to 30 grams/day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

Abstract: A malic acid or oxalacetic acid derivative is represented by the following formula (1): 1

Abstract: The use of L-carnitine, some alkanoyl L-carnitines and the pharmacologically acceptable salts thereof in combination with long-chain alkanols such as polycosanols, or polycosanol-bearing natural products or extracts thereof for the prevention and treatment of diseases caused by abnormal lipid metabolism, such as atherosclerosis, hypercholesterolemia, cardiovascular disorders and peripheral diabetic neuropathy.

Abstract: A pharmaceutical composition consisting essentially of an alkanoul L-camitine wherein the alkanoyl group is linear or branched and as 2-8 carbon atoms, dehydroepiandrosterone or.dehydroepiandrosterone sulphate.

Abstract: A composition useful for increasing the absorption of glutathione and for synergizing its effects. This composition may take the form of a dietary supplement, dietetic support or of an actual medicine and comprises: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; (b) glutathione or a glutathione-containing yeast; (c) a glutathione-free yeast if the component (b) consists of glutathione. The invention is also directed to methods of making this composition as well as to methods of prevention or treatment using it.

Abstract: A composition and method of treating cutaneous infection and resulting inflammation in animals known as hot spots and mange, respectively, as well as related veterinarian dermatological conditions. The composition includes L-glutathione and a source of selenium which act synergistically and which are included in a suitable topical carrier for topical application.

Abstract: The present invention relates to a composition in liquid dosage form of coenzyme Q or ubiquinone which can be formulated into cosmetic, dietary supplement or pharmaceutical dosage form for administration to patients. The dosage form comprises an effective amount of coenzyme Q or ubiquinone ranging from about 0.05% to about 15%, more preferably about 1% to about 10.0% by weight of the composition in combination with a polysorbate surfactant such as a Tween™, surfactant, a vegetable oil or triglyceride, in further combination with a glyceryl ester in amounts effective to produce a liquid dosage form. Optional additives include a phospholipid such as hydroxylated lecithin, among others such as tocopherols or tocopherol esters effective to solubilize the ubiquinone in combination as well as other bioactive agents. Compositions according to the present invention avoid the inclusion of a polyhydric alcohol solvent in solubilizing amounts.

Abstract: The invention relates to the use of certain acid donors as stabilizers in pharmaceutical compositions, and to the stabilized pharmaceutical compositions resulting there-from.

Abstract: The invention relates to the use of certain acid donors as stabilizers in pharmaceutical compositions, and to the stabilized pharmaceutical compositions resulting therefrom.

Abstract: There is provided methods for inhibiting the activity of enveloped viruses, treatment of viral infections and method inactivating sperm. There is provided articles for use in these methods.

Abstract: A natural method for promoting fat, and weight loss while decreasing food cravings comprising administrating to an individual in need thereof L-carnitine, chromium, coenzyme Q10, creatine, lipoic acid, niacin, pyruvate, riboflavin, and thiamine. Pyruvate is a major promoter of the oxidation of dietary fuels like carbohydrates and fatty acids in the citric acid cycle. L-carnitine allow the transport of fatty acids into the mitochondria were they can be degraded in the citric acid cycle. Lipoic acid is a major intracellular antioxidant, and component of key enzymes in the citric acid cycle. Niacin, riboflavin, and thiamine are key components of enzymes that lead to the breakdown of dietary fuel molecules such as fatty acids, amino acids, and carbohydrates that enter the citric acid cycle. The breakdown of these dietary fuels leads to the production of high energy hydrogen atoms. Coenzyme Q10 accepts these hydrogen atoms and utilizes them for cellular energy production.

Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.

Abstract: The invention relates to novel histidine derivatives corresponding to the general formula (I) below: in which: R denotes a linear or branched, saturated or unsaturated alkyl radical containing from 6 to 22 carbon atoms, n is an integer ranging from 1 to 16, Q+ represents H+ or an organic or inorganic cation, and the addition salts with an acid. The invention also relates to a process for preparing the compounds of formula (I), as well as to the use of these compounds in cosmetics and pharmacy.

Abstract: This invention relates to a palatable elemental nutritional formula that is nutritionally complete for humans with specialized dietary needs. The nutritional of the present invention uses specific free amino acids to provide the source of amino nitrogen (protein equivalents) and a special blend of fats that provides 38 to 50% of the total Calories in a pleasant tasting formula. The nutritionally complete formula of this invention is useful for children having multiple protein allergies, short gut syndrome, sick gut, diarrhea and the like. More specifically, the nutritional product, in accordance with this invention, utilizes L-asparagine monohydrochloride and L-glutamine in place of L-aspartic acid and L-glutamic acid, respectively. In addition, the source of fat comprises soy, fractionated coconut oil (medium chain triglycerides), high oleic safflower oil and esterified glycerol emulsifiers.

Abstract: Compositions containing long chain carboxybetaines, and their use in antimicrobial formulations, are described. The compositions and methods are especially useful against gram positive microorganisms such as Staphylococcus and gram negative microorganisms such as Escherichia, Salmonella and Pseudomonas.

Abstract: A therapeutical method is disclosed for treating idiopathic asthenozoospermia which comprises orally or parenterally administering to a patient in need thereof a combination preparation comprising in admixture L-carnitine and acetyl L-carnitine or the pharmacologically acceptable salts thereof, in substantially equimolar amouts.

Abstract: A process for feeding a pet food supplement or diet to an overweight canine for the purpose of promoting weight loss, increasing lean body mass, and enhancing the satiety of the animal is provided. The supplement or diet contains an effective amount of L-carnitine.

Abstract: Lysine and methionine which are limiting amino acids of dairy cows are administered to dairy cows to decrease the BUN value that has an adverse effect on the conception rate and to increase the blood glucose required to improve the energy balance, that alanine and glutamine are administered to dairy cows to increase the blood glucose and to improve the liver function, and that the use of these amino acids is effective for keeping good conditions of dairy cows, allowing earlier arrival of initial estrus without any stress, improving the mating conception rate and decreasing the non-conception rate.

Abstract: This invention relates to L-carnitine and lower alkanoyl L-carnitines in combination with ketanserin, for the therapeutic treatment of Chronic Regional Pain Syndrome (CRPS).

Abstract: Anionic surfactants are used in conjunction with an antifungal acid and a chelating agent to preserve topically administrable pharmaceutical compositions without the need for a conventional preservative such as benzalkonium chloride.

Abstract: The invention relates to fatty acids conjugated to amino acids and their derivatives that elicit the production and/or release of plant volatiles compounds which attract and/or retain beneficial insects and deter herbivorous insect feeding. These conjugates also induce plants to increase production of pharmacologically important compounds such as taxol, increase fragrance of flowers, and increase production of plant essential oil. The invention also relates to methods for isolating the compounds from herbivorous insect oral secretions and to chemically synthesizing the compounds and their active derivatives.

Abstract: A process for feeding a pet food supplement or diet to an overweight canine for the purpose of promoting weight loss, increasing lean body mass, and enhancing the satiety of the animal is provided. The supplement or diet contains an effective amount of L-carnitine.

Abstract: Metal amino acid chelates for animals are beneficial for facilitating and promoting growth by increasing desired metallic ion uptake. The present invention is directed to a process for providing an animal fed additive by preparing metal amino acid chelates, and the metal amino acid chelate growth facilitator, promoter and enhancer prepared by the process.

Abstract: The invention relates to amino acid derivatives of general formula (I), wherein R1 is H or CH3, X is H or NR2R3, wherein R2 is H, CH3, COH or COCH3 and R3 is H, CH3 or COO—Z wherein Z is R2R3 NH+CHR1(CH2)nCOO(CH2)mCH2Y; Y is H, CH3 or NHR4, wherein R4 a COO—NH3+CH2(CH2)mOOC(CH2)nCH3, the meaning of group (CH2)m being selected from alkyls, secondary alkyls, monocycloalkyls, bicycloalkyls and tricycloalkyls having from 4 to 15 carbon atoms and n having a value of from 3 to 14.

Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group including neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigmeninal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, anthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs clinical syndromes of reduces height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiencies and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group including L-acetylcarnitine, L-isovalerylcarnitine, an

Abstract: The use of lower alkanoyl L-carnitines is disclosed for preparing pharmaceutical compositions (particularly foams and enemas) for treating chronic inflammatory bowel diseases, in particular ulcerative colitis.

Abstract: The present invention provides a new therapeutic use of the zwitterionic surfactants, specifically betaines and sulfobetaines, to treat cellular, neoplastic disorders.

Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.

Abstract: Stable and nonhygroscopic salts consisting of L-carnitine magnesium tartrate or lower alkanoyl-L-carnitine magnesium tartrate are disclosed that are suitable for preparing solid compositions useful as dietary or nutritional supplements for human use and as a fodder supplement for veterinary purposes.

Abstract: Stable and non hygroscopic salts of L-carnitine or lower alkanoyl-L-carnitine with 2-aminoethanesulfonic acid are disclosed suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.

Abstract: NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO production can provide for greater aerobic capacity and improved exercise performance.

Abstract: This invention relates to a weight control composition, preferably in the form of a capsule or tablet, comprising a mixture of guggul extract and at least one phosphate salt selected from calcium phosphate, potassium phosphate and sodium phosphate. The composition evidences synergistic activity in reducing body weight and percent body fat in mammals. The guggul extract/phosphate salt product also reduces plasma lipid levels and cholesterol in overweight hyperlipidaemic humans. The inventive composition may also contain at least one additional component selected from phosphatidylcholine, hydroxycitric acid and L-tyrosine.