Inner Quaternary Ammonium Salt (e.g., Betaine, Etc.) Patents (Class 514/556)
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Patent number: 6103666Abstract: Compositions comprising an ionene polymer and a salt of dodecylamine are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: September 10, 1998Date of Patent: August 15, 2000Assignee: Buckman Laboratories International, Inc.Inventors: Fernando Del Corral, Percy Jaquess, David Oppong
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Patent number: 6093411Abstract: The present invention relates to compositions for preventing or treating skin disorders using flavonoid compounds. The present invention also relates to methods for regulating skin condition.Type: GrantFiled: March 12, 1999Date of Patent: July 25, 2000Assignee: The Procter & Gamble CompanyInventor: Donald Lynn Bissett
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Patent number: 6090848Abstract: A method is disclosed for treating idiopathic asthenozoospermia and improving sperm quality which comprises orally or parenterally administering to a subject in need thereof a combination preparation comprising either an admixture of or separately packaged L-carnitine and acetyl L-carnitine, or a pharmacologically acceptable salt thereof, in molar ratios ranging from about 4.0:1 to 1:1.5.Type: GrantFiled: July 28, 1998Date of Patent: July 18, 2000Assignee: Sigma-Tau Healthscience S.p.A.Inventor: Claudio Cavazza
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Patent number: 6090849Abstract: An effective amount of carnitine is administered to broiler breeder type poultry to prevent sudden death syndrome. In the preferred embodiment, a carnitine supplemented diet is fed to broiler breeder type chickens in a feed composition during a period of time preceding peak egg production. The feed composition preferably contains between 5 and 1000 ppm of carnitine.Type: GrantFiled: March 23, 1999Date of Patent: July 18, 2000Assignees: The Board of Regents for Oklahoma State University, Lonza, Inc.Inventors: Robert G. Teeter, Stanley L. Vanhooser, Kevin Q. Owen
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Patent number: 6080786Abstract: Stable and non-hygroscopic salts consisting of L-carnitine or alkanoyl-L-carnitine choline tartrate are disclosed. The salts are suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.Type: GrantFiled: October 8, 1999Date of Patent: June 27, 2000Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Mose Santaniello, Nazareno Scafetta, Maria Ornella Tinti
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Patent number: 6063820Abstract: A medical food for diabetics is disclosed which comprises as characterizing active ingredients .gamma.-linolenic acid and at least one alkanoyl-L-carnitine, e.g. acetyl-L-carnitine and/or propionyl-L-carnitine.Type: GrantFiled: March 18, 1998Date of Patent: May 16, 2000Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 6054139Abstract: The invention relates to a cleaning and/or disinfecting composition comprising a tertiary alkyl amine and an alkyl betaine.Type: GrantFiled: May 9, 1997Date of Patent: April 25, 2000Assignee: Diversey Lever Inc.Inventors: Ronald Joseph Lambert, Moira Diane Johnston, Eduard C. van Baggem, Gijsbertus de Goederen
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Patent number: 6051608Abstract: Stable and non-hygroscopic salts consisting of L-carnitine or alkanoyl-L-carnitine magnesium fumarate are disclosed which are suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.Type: GrantFiled: October 8, 1998Date of Patent: April 18, 2000Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Mose Santaniello, Nazareno Scafetta, Maria Ornella Tinti
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Patent number: 6037373Abstract: A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group consisting of neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigeminal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, arthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs, clinical syndromes of reduced height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiencies and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group consisting of L-acetylcarnitine, L-isovalerylcarniType: GrantFiled: January 4, 1999Date of Patent: March 14, 2000Assignees: SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A., MENDES s.r.l.Inventor: Claudio De Simone
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Patent number: 6020139Abstract: A new paradigm of disease centers around the metabolic pathways of S-adenosyl-L-methionine (SAM), the intermediates of these pathways and other metabolic pathways influenced by the SAM pathways. Methods are provided to analyze and modulate SAM pathways associated with a disease or condition. Such methods permit identification and utilization of diagnostic and therapeutic protocols and agents for such disease states and conditions.Type: GrantFiled: April 25, 1995Date of Patent: February 1, 2000Assignee: Oridigm CorporationInventors: Dennis E. Schwartz, Nicolaas M. J. Vermeulen, Christine L. O'Day
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Patent number: 6013670Abstract: The present invention relates to a therapeutic use of the lower alkanoyl L-carnitines and the pharmacologically acceptable salts thereof in pharmaceutical compositions for the treatment of ulcerative colitis.Type: GrantFiled: June 4, 1997Date of Patent: January 11, 2000Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 5998474Abstract: Therapeutic use is described of L-carnitine, alkanoyl L-carnitines and pharmacologically acceptable salts thereof, in combination with hydrophilic antioxidants or lipophilic antioxidants for the prevention or treatment of a disturbance or disease elicited by oxidative stress.Type: GrantFiled: March 18, 1997Date of Patent: December 7, 1999Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 5998475Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: March 20, 1997Date of Patent: December 7, 1999Inventors: Lynn Sue James, Michael A. Siedman
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Patent number: 5993864Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.Type: GrantFiled: July 11, 1997Date of Patent: November 30, 1999Inventor: Robert D. Kross
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Patent number: 5985593Abstract: The present invention is related to a method for the enzymatic decontamination of specimens as a means to control microbiological contamination. The compositions and methods of the invention are especially useful to eliminate non-gram negative contaminants of samples being processed for microbiological analysis.Type: GrantFiled: October 3, 1997Date of Patent: November 16, 1999Assignee: Integrated Research Technology, L.L.C.Inventors: Charles G. Thornton, Kerry M. MacLellan
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Patent number: 5976550Abstract: A dietary food supplement for weight reduction formed of a mixture of a sugar based confectionary containing therapeutic amounts of chitosan, kava and a fat burning nutriceutical which may include choline/inusital, chromium picolinate, beta-hydroxy-beta-methyl butyrate, L-carnitine and pyruvate or any combination thereof.Type: GrantFiled: November 20, 1998Date of Patent: November 2, 1999Inventors: Peter H. Engel, Howard Cohl
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Patent number: 5977162Abstract: A nutritional supplement for enhancing mitochondrial function in cells includes 10-1000 mg of alpha-lipoic acid, 10-1000 mg acetyl-L-carnitine, 15-360 mg coenzyme Q-10, and 15-360 mg glutathione. The composition may further comprise a carrier for these components such as a liquid or tablet for oral ingestion on a daily basis.Type: GrantFiled: September 16, 1997Date of Patent: November 2, 1999Inventor: Michael D. Seidman
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Patent number: 5965615Abstract: The invention relates to a hydroxyl radical scavenger and a remedy composition for a disease caused by a hydroxyl radical, which each comprise, as an active ingredient, a betaine represented by the formula (1):(CH.sub.3).sub.3 N.sup.+ (CH.sub.2).sub.n COO.sup.- (1)wherein n is an integer of 1-5, or an acid-addition salt or ester salt thereof. The betaine is useful in treating a disease caused by a hydroxyl radical, in particular, cardiopathy.Type: GrantFiled: March 25, 1997Date of Patent: October 12, 1999Assignees: Taiho Pharmaceutical Co., Ltd., Valsts zinatniska iestade - bezpelnas organizacija Latvijas organiskas sintezes institutsInventors: Ivars Kalvinsh, Maris Veveris, Yasushi Abiko, Kiyotaka Tajima
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Patent number: 5955424Abstract: The use of L-carnitine or of an alkanoyl L-carnitine or their pharmacologically acceptable salts is described for producing a medicament for inhibiting nephrotoxicity and vasculotoxicity resulting from the administration of an immunosuppressant drug such as cyclosporin-A, tacrolimus, rapamicine and deoxyspergualine.Type: GrantFiled: January 3, 1996Date of Patent: September 21, 1999Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Menotti Calvani, Luigi Mosconi
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Patent number: 5952379Abstract: Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines with mucic acid of formula (I) are disclosed wherein the molar ratio between the carnitine moiety and mucic acid is 2:1. A process for producing the salts and solid orally administrable compositions containing same are also disclosed.Type: GrantFiled: November 30, 1998Date of Patent: September 14, 1999Assignee: Sigma-Tau Industrie FarmaceuticheInventor: Aldo Fassi
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Patent number: 5948443Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.Type: GrantFiled: February 21, 1997Date of Patent: September 7, 1999Assignee: Medical Doctor's Research Institute, Inc.Inventors: Patricia A. Riley, George Christakis
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Patent number: 5929073Abstract: Compositions for controlling the growth of microorganisms in or on a product, material, or medium comprising synergistically effective amounts of (a) dodecylmorpholine or a salt thereof and (b) dodecylamine or a salt thereof are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: September 16, 1997Date of Patent: July 27, 1999Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, Percy A. Jaquess, Fernando Del Corral, Marilyn S. Whittemore
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Patent number: 5922649Abstract: Exogenous use of betaine and adjuvant improves the yield of plants. Betaine and adjuvant can be applied either together or separately and used under both normal and stress conditions. Also disclosed are combinations of betaine and adjuvant, treatment of plants exogenously with betaine and adjuvant, and products obtained from such plants.Type: GrantFiled: April 10, 1997Date of Patent: July 13, 1999Assignee: Cultor OYInventors: Eija Pehu, Jussi Hautala, Esko Kokkonen
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Patent number: 5922766Abstract: This invention relates to a palatable elemental nutritional formula that is nutritionally complete for humans with specialized dietary needs. The nutritional of the present invention uses specific free amino acids to provide the source of amino nitrogen (protein equivalents) and a special blend of fats that provides 38 to 50% of the total Calories in a pleasant tasting formula. The nutritionally complete formula of this invention is useful for children having multiple protein allergies, short gut syndrome, sick gut, diarrhea and the like. More specifically, the nutritional product, in accordance with this invention, utilizes L-asparagine monohydrochloride and L-glutamine in place of L-aspartic acid and L-glutamic acid, respectively. In addition, the source of fat comprises soy, fractionated coconut oil (medium chain triglycerides), high oleic safflower oil and esterified glycerol emulsifiers.Type: GrantFiled: July 2, 1997Date of Patent: July 13, 1999Inventors: Phyllis J. B. Acosta, Marlene W. Borschel, Patricia A. Reynolds, Christopher T. Cordle, Geralyn O. Duska-McEwen
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Patent number: 5883127Abstract: The use of lower alkanoyl L-carnitines (e.g. acetyl L-carnitine) and the pharmacologically acceptable salts thereof to produce a medicament suitable for the therapeutic treatment of retinopathies, e.g. the age-related maculopathy (ARM) and non-age-related maculopathy (nARM), is disclosed.Type: GrantFiled: November 25, 1997Date of Patent: March 16, 1999Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.AInventor: Claudio Cavazza
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Patent number: 5883083Abstract: A dietary supplement for canines and felines includes taurine in a liquid lecithin base. The dietary supplement has proven effective in reducing epileptic seizures in canines and in reducing behavioral problems, such as aggression, in canines. In addition, the dietary supplement is more easily digestible than conventional tablet forms of taurine and is more effectively administered to felines for treatment of cardiomyopathy.Type: GrantFiled: June 9, 1997Date of Patent: March 16, 1999Assignee: Harlmen, Inc.Inventor: Stanely James Harless
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Patent number: 5880098Abstract: The present invention is directed to a therapy involving administering effective amounts of an organic osmolyte selected from the group consisting of polyols, amino acids and methyl amines, that regulate hydration of certain cells, for treating or preventing complications resulting from ischemia, hypoxia or oxidative stress.Type: GrantFiled: June 19, 1997Date of Patent: March 9, 1999Assignee: Pharmacia & Upjohn AktiebolagInventor: Dieter Haussinger
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Patent number: 5869528Abstract: A therapeutical method for the treatment of Attention-Deficit/Hyperactive Disorder (ADHD) is disclosed which comprises administering to a child in need thereof L-carnitine or an alkanoyl L-carnitine or a pharmacologically acceptable salt thereof.Type: GrantFiled: July 22, 1997Date of Patent: February 9, 1999Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 5863940Abstract: A therapeutical method is disclosed for treating idiopathic asthenozoospermia which comprises orally or parenterally administering to a patient in need thereof a combination preparation comprising in admixture L-carnitine and acetyl L-carnitine or the pharmacologically acceptable salts thereof, in substantially equimolar amouts.Type: GrantFiled: December 1, 1997Date of Patent: January 26, 1999Assignee: Sigma-Tau HealthScience S.p.A.Inventor: Claudio Cavazza
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Patent number: 5859056Abstract: A pharmaceutical composition containing 3-(2,2,2-trimethylhydrazinium)propionate and .gamma.-butyrobetaine with a pharmaceutically acceptable carrier for the treatment of cardiovascular diseases is disclosed. The composition may be for oral, parenteral, subcutaneous or rectal administration and exhibits low toxicity and a wide interval of therapeutic action safety.Type: GrantFiled: February 19, 1998Date of Patent: January 12, 1999Inventors: Ivars Kalvinsh, Maris Veveris
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Patent number: 5853743Abstract: A light duty liquid detergent with desirable cleansing properties and mildness to the human skin comprising: at least one sulfonate surfactant, an alkali metal or ammonium salt of a C.sub.8-18 ethoxylated alkyl ether sulfate anionic surfactant, a betaine surfactant, an alkyl polyglucoside surfactant, an ethoxylated alkyl C.sub.12 -C.sub.14 monoalkanol amide, optionally, C.sub.12 -C.sub.14 monoalkanol amide and water.Type: GrantFiled: August 5, 1997Date of Patent: December 29, 1998Assignee: Colgate Palmolive CompanyInventors: Joan E. Gambogi, Gary J. Jakubicki, Leonard A. Zyzyck
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Patent number: 5851953Abstract: Exogenous use of betaine on tobacco plants improves the yield, especially tobacco plants grown under stress conditions.Type: GrantFiled: March 5, 1997Date of Patent: December 22, 1998Assignee: Cultor OYInventors: Eija Pehu, Erkki Virtanen, Kirsti Jutila
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Patent number: 5849728Abstract: The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.Type: GrantFiled: May 15, 1997Date of Patent: December 15, 1998Assignee: The Procter & Gamble CompanyInventor: Donald L. Bissett
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Patent number: 5843865Abstract: Compositions comprising an ionene polymer and a salt of dodecylamine are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: February 6, 1997Date of Patent: December 1, 1998Assignee: Buckman Laboratories International, Inc.Inventors: Fernando Del Corral, Percy Jaquess, David Oppong
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Patent number: 5834473Abstract: The invention is directed to methods for the treatment of coccidiosis and compositions designed to be administered to animals infected with coccidiosis-inducing organism. The compositions contain an osmoprotectant, and especially, betaine.Type: GrantFiled: June 5, 1997Date of Patent: November 10, 1998Assignee: Cultor, Ltd.Inventors: Erkki Virtanen, Mika Koivistoinen, James L. McNaughton, Liisa Rosi
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Patent number: 5786379Abstract: Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.Type: GrantFiled: December 2, 1996Date of Patent: July 28, 1998Assignee: Centre International de Recherches Dermatologiques GaldermaInventor: Jean-Michel Bernardon
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Patent number: 5776503Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: July 24, 1997Date of Patent: July 7, 1998Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5770233Abstract: An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present invention is constituted by the use of a container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars, fat-soluble vitamins and specified water-soluble vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specified water-soluble vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: April 21, 1995Date of Patent: June 23, 1998Assignee: The Green Cross CorporationInventors: Takae Kido, Shigeo Ii, Shun-ichi Abe, Kazumasa Yokoyama
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Patent number: 5760078Abstract: A process is provided for the preparation of valuable products from vinasse which contains potassium salts. The process comprises concentrating the vinasse to a dry matter content of 50-80% dry solids and separating the formed crystals in a concentration step to form a supernatant which is free of potassium salts. Ammonium sulphate is added to the vinasse before or during concentrating the vinasse.Furthermore, clarification of the supernatant is carried out to provide for the separation of betaine, PCA, succinic acid or citric acid. Filtration, or microfiltration is used for the clarification and a chromatographic separation is used for the separation of betaine as well as the other products. Potassium salts are obtained from the crystals to provide for a fertilizer.Type: GrantFiled: April 3, 1996Date of Patent: June 2, 1998Assignee: Gist-Brocades B.V.Inventors: Reinder Sietze Hamstra, Peter Johannes Schoppink
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Patent number: 5753703Abstract: A novel therapeutic use of L-carnitine or alkanoyl L-carnitine is disclosed in combination with a polyunsaturated fatty acid of the omega-3 series, for the prevention and the treatment of lipid metabolism disorders and cardiovascular disorders.Type: GrantFiled: November 22, 1996Date of Patent: May 19, 1998Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Claudio Cavazza, Menotti Calvani
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Patent number: 5753270Abstract: A preparation which is compatible with the skin for the treatment of labial disease and acne. The preparation comprises a mixture of:(a) at least one compound selected from an antiseptic compound and an anesthetic compound which is:(i) a terpene,(ii) a phenolic compound, or(iii) an alcohol;(b) a quaternary ammonium antiseptic compound;(c) an antiseptic compound selected from compounds containing iodine, salts thereof and complexes thereof dissolved in an organic skin penetrating solvent, wherein said solvent comprises acetone.Type: GrantFiled: December 21, 1995Date of Patent: May 19, 1998Assignees: Patrick A. Beauchamp, James A. RogersInventors: Patrick A. Beauchamp, James A. Rogers
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Patent number: 5747536Abstract: The coordinated therapeutic use of L-carnitine, lower alkanoyl L-carnitines or the pharmacologically acceptable salts thereof with resveratrol, resveratrol derivatives or resveratrol-containing natural products is disclosed for producing a medicament for the prophylaxis and treatment of cardiovascular disorders, peripheral vascular diseases and peripheral diabetic neuropathy.Type: GrantFiled: October 2, 1996Date of Patent: May 5, 1998Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 5733539Abstract: The invention discloses a bait for fishes and shellfishes characterized in that the bait comprises a matrix material containing a microorganically fermented product of a plant residue obtained by separating from a plant at least one liquid selected from the group consisting of vegetable juice, fruit juice, plant essential oil, juice extracted from a processed plant product, plant milk and mixtures thereof, or disintegrated product of said microorganically fermented product, wherein the matrix material has incorporated therein (A) an amino acid having 2 or 3 carbon atoms, and (B) amino acid having at least 4 carbon atoms in an (A)/(B) molar ratio of 1:1 to 40:1.Type: GrantFiled: July 13, 1997Date of Patent: March 31, 1998Assignee: Research Institute for Production DevelopmentInventors: Hisao Kitano, Masahiro Matsuda, Yasushi Ifuku, Hisao Maeda, Yoshifumi Matsuda
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Patent number: 5730988Abstract: The invention provides nutritional supplements and methods for administering nutritional supplements that improve glucose metabolism, particularly for persons with diabetes. A first nutritional supplement, or "Phase I" supplement, comprises a source of vanadate and a source of chromium. A second nutritional supplement, or "Phase II" supplement, comprises Gymnema sylvestre and lipoic acid. The nutritional supplements are alternated to prevent accumulation of the nutrients in the body and also to overcome desensitization that can occur over long periods of continuous use. While the nutritional supplements may be alternated at almost any frequency and taken over almost any duration, it is preferred that each Phase be taken for between about 2 and about 6 months, most preferably about 3 months or about 90 days, before alternating back to the other Phase.Type: GrantFiled: March 24, 1997Date of Patent: March 24, 1998Assignee: Lynntech, Inc.Inventor: Rick W. Womack
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Patent number: 5703127Abstract: A dosage unit for treating stomach disorders, comprises an effective dosage of L- or DL-Methionine, and an effective dosage of a sweetener.Type: GrantFiled: January 25, 1996Date of Patent: December 30, 1997Inventor: Kyoungsik Pak
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Patent number: 5698230Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: March 24, 1997Date of Patent: December 16, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5686491Abstract: The present invention provides an infant formula for infants with metabolic disorders in fatty acid catabolism such as medium-chain acyl-CoA dehydrogenase deficiency (MCAD), long-chain acyl-CoA dehydrogenase deficiency (LCAD), short-chain acyl-CoA dehydrogenase deficiency (SCAD), multiple acyl-CoA dehydrogenase deficiency (MADD), Sudden Infant Death Syndrome (SIDS) and failure to thrive syndrome. The present invention also provides an assay for diagnosing children and infants with metabolic disorders such as failure to thrive syndrome; a method for treating failure to thrive syndrome; and a process for normalizing the lipid content of the mitochondrial membrane. In particular, the present invention provides an infant formula containing 90-130 cals/Kg which comprises (a) 2.5-3.5 g/Kg protein; (b) carbohydrate; (c) fat; and (d) .gtoreq.500 mg carnitine, wherein the ratio of carbohydrate to fat is greater than or equal to 60:40.Type: GrantFiled: September 14, 1994Date of Patent: November 11, 1997Assignee: Sigma-Tau Pharmaceuticals, Inc.Inventor: Geoffrey Sherwood
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Patent number: 5681852Abstract: The subject invention relates to desquamation compositions comprising a combination of sulfhydryl compounds and zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.Type: GrantFiled: June 7, 1995Date of Patent: October 28, 1997Assignee: The Procter & Gamble CompanyInventor: Donald L. Bissett
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Patent number: 5670176Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: April 4, 1995Date of Patent: September 23, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5667774Abstract: Disclosed are novel crosslinked polymeric ammonium salts wherein in said salt: about 25% or more of the groups which link ammonium nitrogen atoms are group Y wherein Y is an-alkylene groups or alkyl substituted n-alkylene group, wherein said n-alkylene group has 7 to about 20 carbon atoms; zero to about 75% of groups which links ammonium nitrogen atoms are group Z wherein Z is a hydrocarbylene radical containing 2 or more carbon atoms, said hydrocarbylene radical optionally containing one or more hydroxyl, ether, amino, thioether, keto, or silyl groups or heterocyclic rings; and about 25% or more of the ammonium atoms are secondary ammonium atoms.Type: GrantFiled: November 7, 1996Date of Patent: September 16, 1997Assignee: E.I. Du Pont de Nemours and CompanyInventor: Garret Daniel Figuly