Silicon Containing Doai Patents (Class 514/63)
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Patent number: 9682948Abstract: In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted flavone derivatives disclosed herein are prodrugs of 7,8-dihydoxyflavone and analogs.Type: GrantFiled: November 1, 2013Date of Patent: June 20, 2017Assignee: Emory UniversityInventor: Keqiang Ye
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Patent number: 9656965Abstract: A new one-step process for the preparation of pyrazole carboxamide derivatives of the general formula (I) by reaction of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde with an amine or its salt.Type: GrantFiled: September 4, 2014Date of Patent: May 23, 2017Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Peter Bruchner, Sergii Pazenok
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Patent number: 9642793Abstract: Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, Commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.Type: GrantFiled: August 15, 2014Date of Patent: May 9, 2017Assignee: Mary Kay Inc.Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
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Patent number: 9617286Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivatives with formula: their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.Type: GrantFiled: November 20, 2012Date of Patent: April 11, 2017Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Juergen Benting, Pierre Cristau, Philippe Desbordes, Helene Lachaise, Philippe Rinolfi
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Patent number: 9586192Abstract: Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing functional group. The medium or the scaffold including the selenium-containing functional group has affinity and specificity to metal ions or compounds having one or more metals, and efficiently separates, recovers, and scavenges of the metals from a target such as a sample, solution, suspension, or mixture.Type: GrantFiled: January 20, 2015Date of Patent: March 7, 2017Assignee: BROWN UNIVERSITYInventors: Yongsong Huang, James Dillon
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Patent number: 9585382Abstract: The present invention relates to an agrochemical composition comprising a pesticide and a solvent of the formula (B) as described hereinbelow. The invention furthermore relates to a process for the preparation of the composition by bringing the pesticide and the solvent into contact; a use of the solvent of the formula (B) as a solvent for pesticides; methods for controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or on the plants to be protected from the respective pest, on the soil and/or on undesired plants and/or on the crop plants and/or on their environment; and on seed comprising the composition.Type: GrantFiled: April 27, 2012Date of Patent: March 7, 2017Assignee: BASF SEInventors: Paul Klingelhoefer, Gerhard Schnabel, Ralf Pelzer, Wolfgang Spiegler
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Patent number: 9572788Abstract: The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.Type: GrantFiled: May 13, 2014Date of Patent: February 21, 2017Assignee: President and Fellows of Harvard CollegeInventors: Randall King, Xing Zeng, Katharine L. Sackton
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Patent number: 9555046Abstract: The invention provides and describes solid state 17?-ethynyl-androst-5-ene-3?,7?,17?-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17?-ethynyl-androst-5-ene-3?,7?,17?-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17?-ethynyl-androst-5-ene-3?,7?,17?-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17?-ethynyl-androst-5-ene-3?,7?,17?-triol and uses of such formulations in treating the described conditions.Type: GrantFiled: August 14, 2014Date of Patent: January 31, 2017Assignee: NEURMEDIX, INC.Inventors: Steven K White, Igor Ivanisevic, Kyle Stephens, Mark Andres, Brenton Skylar Wolfe
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Patent number: 9556205Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.Type: GrantFiled: June 1, 2011Date of Patent: January 31, 2017Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jurgen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Marie-Claire Grosjean-Cournoyer, Hiroyuki Hadano, Ruth Meissner, Rachel Rama, Philippe Rinolfi, Ulrike Wachendorff-Neumann
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Patent number: 9522935Abstract: Lanosterol derivatives useful as anti-cancer agent, which can inhibit the growth of lung cancer cells, liver cancer cells, mammary cancer cells, brain cancer cells and pancreatic cancer cells, possibly by acting on the RHO pathway.Type: GrantFiled: January 27, 2014Date of Patent: December 20, 2016Inventors: Xin Liu, Weidong Xie
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Patent number: 9481613Abstract: Insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizers are disclosed. The compositions include bifenthrin, a polymeric dispersant, a suspension agent, a freeze-thaw stabilizer, and optionally a preservative.Type: GrantFiled: January 15, 2015Date of Patent: November 1, 2016Assignee: FMC CorporationInventor: Timothy M. Martin
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Patent number: 9447126Abstract: Methods and systems for making camptothecin analogs and intermediates are provided. Aspects include safer and lower cost methodologies for making camptothecin analogs and intermediates from synthetic materials. In another aspect, the methods and systems can achieve a yield of the camptothecin analogs greater than about 0.4%.Type: GrantFiled: October 20, 2015Date of Patent: September 20, 2016Assignee: ARNO THERAPEUTICS, INC.Inventors: Bin-Feng Li, Ke Yuan
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Patent number: 9439426Abstract: The present invention relates to active compound combinations, in particular within a composition, which comprises (A)) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and (B) a biological control agent. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: GrantFiled: October 17, 2013Date of Patent: September 13, 2016Assignee: BAYER CROPSCIENCE AGInventors: Pierre Cristau, Peter Dahmen
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Patent number: 9428505Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.Type: GrantFiled: December 10, 2013Date of Patent: August 30, 2016Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
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Patent number: 9422303Abstract: Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical preparations for use in disease treatment, such as cancer therapy. The compositions include novel pharmaceutical preparations which contain effective concentrations of a chemical compound. One compound used is 10H-1,3-Dioxolo[4,5-g]pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-8,11(7H,12H)-dione, 7-ethyl-7-hydroxy-, (S)-. The invention also provides methodologies for preparing pharmaceutical preparations for use in intravenous and oral pharmaceutical preparations that contain drug compounds that are difficult to dissolve in water.Type: GrantFiled: October 31, 2011Date of Patent: August 23, 2016Assignee: Health Research, Inc.Inventors: Fengzhi Li, Xiang Ling, Shousong Cao
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Patent number: 9352049Abstract: The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.Type: GrantFiled: March 13, 2014Date of Patent: May 31, 2016Assignee: Albany Molecular Research, Inc.Inventors: Peter R. Guzzo, David D. Manning
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Patent number: 9271930Abstract: Intermediate compositions and in particular gels and suspensions for a foam composition comprising adapalene are described. Also described, is the dermatological use of such compositions.Type: GrantFiled: December 22, 2011Date of Patent: March 1, 2016Assignee: GALDERMA RESEARCH AND DEVELOPMENTInventor: Emmanuelle At
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Patent number: 9265254Abstract: A granular pesticidal composition which comprises a pyrazolinone compound given by the formula (1): wherein R1 represents a chlorine atom etc.; R2 represents a chlorine atom etc.; R3 represents a 1-methylethyl group etc.; and R4 represents a C1-C4 alkoxy group etc. and a salt of ligninsulfonic acid, and the amount of the salt of ligninsulfonic acid in the granular pesticidal composition is 10-60% by weight has good disintegrability in water when it is diluted with water.Type: GrantFiled: October 24, 2005Date of Patent: February 23, 2016Assignee: Sumitomo Chemical Company, LimitedInventors: Toshiro Otsubo, Rei Matsunaga, Eriko Takeko
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Patent number: 9216950Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.Type: GrantFiled: August 3, 2012Date of Patent: December 22, 2015Assignees: NATIONAL TAIWAN UNIVERSITY, NATIONAL YANG-MING UNIVERSITY, DCB-USA LLCInventors: Chung-Wai Shiau, Kuen-Feng Chen
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Patent number: 9205069Abstract: The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibiting the ubiquitination activity of the APC by administering compositions of the invention.Type: GrantFiled: March 8, 2010Date of Patent: December 8, 2015Assignee: President and Fellows of Harvard CollegeInventors: Randall King, Xing Zeng, Shantanu Gaur
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Patent number: 9198415Abstract: The present invention is directed to methods of increasing the environmental stress tolerance of a plant, to methods of improving the quality and/or yield of a plant crop, to methods of application of agrochemicals having a physiological effect on a plant in the plant irrigation water, and to crops produced using said methods.Type: GrantFiled: June 3, 2011Date of Patent: December 1, 2015Assignee: Syngenta Participations AGInventors: Ulrich Johannes Haas, Christophe Weider, Ronald Zeun, Albert Bassi, Daniel Perkins
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Patent number: 9187450Abstract: The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.Type: GrantFiled: July 8, 2011Date of Patent: November 17, 2015Assignee: Daiichi Sankyo Company, LimitedInventors: Tsuyoshi Nakamura, Hidenori Namiki, Naoki Terasaka, Akiko Shima, Masahiko Hagihara, Noriaki Iwase, Katsunori Takata, Osamu Kikuchi, Kazunari Tsuboike, Hiroyuki Setoguchi, Kenji Yoneda, Hidetoshi Sunamoto, Koji Ito
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Patent number: 9145367Abstract: The present invention relates to compound Formula (I) wherein: Formula (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR1 group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a NO2 group, a NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group and a (C1-C3)alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group, a hydroxyl group, a COOR1 group, a NO2 group, a NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating AIDS. Some of said compounds are new and also form part of the invention.Type: GrantFiled: June 14, 2010Date of Patent: September 29, 2015Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER 2Inventors: Jamal Tazi, Florence Mahuteau, Romain Najman, Didier Scherrer, Noelie Campos, Aude Garcel
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Patent number: 9138440Abstract: This document provides methods and materials involved in reducing suppression of immune function in mammals. For example, methods and materials for (a) identifying a mammal as having an elevated level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and (b) administering RU486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that change the ratio of CD14+/HLA-DR? cells to CD14+/HLA-DR+ cells as well as methods and materials for (a) identifying a mammal as being likely to experience an elevated level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and (b) administering RU486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that reduce the degree to which the mammal develops CD14+/DR? cells are provided.Type: GrantFiled: April 5, 2012Date of Patent: September 22, 2015Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Peggy A. Bulur
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Patent number: 9102642Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: GrantFiled: January 25, 2010Date of Patent: August 11, 2015Assignee: Syngenta LimitedInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Patent number: 9096550Abstract: Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.Type: GrantFiled: October 14, 2010Date of Patent: August 4, 2015Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Gary E Keck, Matthew B Kraft, Anh P Truong, Carina C Sanchez, Wei Li, Jonathan A Covel, Dennie Welch, Yam Poudel
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Patent number: 9079926Abstract: The invention relates to a method for treating an ammonium halogenide and/or residue containing organic aminhydrohalogenides, produced during the production of an amino-functional organosilane of general formula (I) R2N[(CH2)2NH]z(Z)Si(R?)n(OR?)3-n (Ia), wherein the production of the amino-functional organosilane according to formula (Ia) is based on the conversion of a halogen-functional organosilane of general formula (II) X—Z—Si(R?)n(OR?)3-n (II), with excess ammonia or an organic amine of general formula (III) RNH[(CH2)2NH]zR (III) and subsequently separating and treating the raw product and the resulting residue containing salt. The treatment consists of adding an essentially non-polar organic solvent and an aqueous lye to the residue. The mixture is reacted, subsequently the aqueous phase is separated from the organic phase, the organic solvent contained in the organic phase is removed from said phase and the residual organic phase is recovered.Type: GrantFiled: April 20, 2009Date of Patent: July 14, 2015Assignee: Evonik Degussa GmbHInventors: Philipp Albert, Eckhard Just
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Publication number: 20150147375Abstract: The present invention relates to broad spectrum antiseptic or antimicrobial compositions that may be coated or impregnated on medical articles.Type: ApplicationFiled: December 19, 2013Publication date: May 28, 2015Applicant: Medline Industries, Inc.Inventor: David Jaeger
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Publication number: 20150147366Abstract: The present invention relates to a cosmetic composition for making up and/or caring for the skin and/or the lips, comprising, in a physiologically acceptable medium, at least one oil, which is preferably non-volatile, at least hydrophobic silica aerogel particles, at least one hydrocarbon-based resin having a number-average molecular weight of less than or equal to 10 000 g/mol, the said composition comprising less than 5% by weight of water relative to the total weight of the composition, and preferably being anhydrous.Type: ApplicationFiled: June 21, 2013Publication date: May 28, 2015Applicant: L'OREALInventors: Stephane Arditty, Frederic Auguste, Virginie Perez Nowak
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Publication number: 20150139921Abstract: The invention relates generally to gels or viscous fluids formed by the coordination of certain amino-functionalized siloxanes with titanates and the use of the same in cosmetic compositions, including for providing long-wearing, comfortable films on a keratinous surface (e.g., lips). The gels or viscous fluids may exhibit unique rheological properties, including shear thickening (dilatancy) and/or rheopecty, at low shear rates which may lead to self-leveling effects, including renewable shine.Type: ApplicationFiled: March 13, 2014Publication date: May 21, 2015Inventors: Allwyn Colaco, Mohannad Abdo
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Publication number: 20150140063Abstract: A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10.Type: ApplicationFiled: January 22, 2015Publication date: May 21, 2015Applicant: BRIGHAM YOUNG UNIVERSITYInventor: Paul B. Savage
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Publication number: 20150141372Abstract: Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.Type: ApplicationFiled: May 8, 2013Publication date: May 21, 2015Inventors: Marion Hitchcock, Christoph-Stephan Hilger, Anne Mengel, Hans Briem, Simon Holton, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Cornelia Preuße, Mark Jean Gnoth
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Patent number: 9034848Abstract: A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing stroke comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of stroke treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or preventing stroke, are provided.Type: GrantFiled: December 27, 2012Date of Patent: May 19, 2015Assignee: Bio-Pharm Solutions Co., Ltd.Inventor: Yong Moon Choi
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Publication number: 20150133400Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.Type: ApplicationFiled: September 15, 2014Publication date: May 14, 2015Inventors: Jiazhong Zhang, John Buell, Katrina Chan, Prabha N. Ibrahim, Jack Lin, Phuongly Pham, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jeffrey Wu
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Patent number: 9028880Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.Type: GrantFiled: November 30, 2011Date of Patent: May 12, 2015Assignee: The Board of Trustees of the University of IllinoisInventors: Jianjun Cheng, Li Tang
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Patent number: 9029352Abstract: The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.Type: GrantFiled: August 5, 2013Date of Patent: May 12, 2015Assignee: Janssen Pharmaceutica NVInventors: Krzysztof Kolodziejczyk, Alfred Elisabeth Stappers, Christopher A. Teleha, Koen Johan Herman Weerts
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Publication number: 20150126475Abstract: To provide a pesticidal composition having a broad pesticidal spectrum, having high activity and having a long lasting effect. A pesticidal composition comprising as active ingredients at least one organic phosphorus compound (A) selected from the group consisting of fosthiazate and imicyafos and at least one compound (B) selected from the group consisting of clothianidin, dinotefuran, thiamethoxam, tefluthrin, silafluofen, chlorfluazuron, flufenoxuron and teflubenzuron (excluding a combination of fosthiazate and tefluthrin).Type: ApplicationFiled: July 2, 2013Publication date: May 7, 2015Applicant: ISHIHARA SANGYO KAISHA, LTD.Inventor: Hideshi Yoshimura
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Publication number: 20150126474Abstract: Using a whole-cell high-throughput screen, eleven molecules were identified that activate V. cholerae quorum sensing (QS). Eight molecules are receptor agonists and three molecules are antagonists of LuxO, the central NtrC-type response regulator that controls the global V. cholerae QS cascade. Pro-QS molecules are used for the development of novel anti-infectives.Type: ApplicationFiled: February 20, 2013Publication date: May 7, 2015Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Bonnie L. Bassler, Wai-Leung Ng, Lark J. Perez, Jianping Cong, Martin F. Semmelhack
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Publication number: 20150126476Abstract: The present invention relates to the use of topical compositions containing bromociclen for the prevention and/or treatment of various types of dermatitis, in particular eczema and psoriasis.Type: ApplicationFiled: January 2, 2015Publication date: May 7, 2015Inventor: Carmelo Cutrupi
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Publication number: 20150118270Abstract: The present invention relates to a composition comprising an aqueous phase, at least one mattifying filler and at least one silane corresponding to formula (I) below and/or oligomers thereof: R1Si(OR2)z(R3)x(OH), (I) in which: Ri is a linear or branched, saturated or unsaturated C1-C22 hydrocarbon-based chain, which may be substituted with an amine group NH2 or NHR (R=C1-C20 and especially C1-C6 alkyl, C3-C40 cycloalkyl or C6-C30 aromatic); or with a hydroxyl group, a thiol group, an aryl group (more particularly benzyl), which is substituted or unsubstituted; Ri possibly being interrupted with a heteroatom (O, S or NH) or a carbonyl group (CO), R2 and R3, which may be identical or different, represent a linear or branched alkyl group comprising from 1 to 6 carbon atoms, y denotes an integer ranging from 0 to 3, and z denotes an integer ranging from 0 to 3, and x denotes an integer ranging from 0 to 2, with z+x+y=3, The invention also relates to a cosmetic process for making up and/or caring for keratin materType: ApplicationFiled: April 24, 2013Publication date: April 30, 2015Inventors: Raluca Lorant, Nathalie Guillier, Mathieu Chabrillangeas
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Publication number: 20150118171Abstract: A cosmetic composition in a physiologically acceptable medium containing a fatty phase, a non-volatile oil, a hydrophobic silica aerogel, and a hydrocarbon-based block copolymer. The hydrocarbon-based block copolymer is obtained from a styrene monomer. The cosmetic composition is anhydrous, with less than 5% by weight of water relative to the total weight of the composition. The cosmetic composition is used for making up and/or caring for the skin and/or the lips.Type: ApplicationFiled: June 21, 2013Publication date: April 30, 2015Applicant: L'OREALInventors: Stephane Arditty, Frederic Auguste, Veronique Jacques
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Publication number: 20150119361Abstract: The invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a compound of formula (I) and at least one farther respiratory chain complex in inhibitor (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: ApplicationFiled: December 24, 2014Publication date: April 30, 2015Inventors: Burkhard SCHÜTZ, Peter Dahmen, Ulrike Wachendorff-Neumann, Peter Herold
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Patent number: 9017650Abstract: Aminofunctional silicone emulsions are prepared by forming a mixture of A) 100 parts of a polydialkylsiloxane Having a viscosity of at least 50,000 mm/s at 23° C., and B) 0.1 to 100 parts of an aminofunctional organopolysiloxane, admixing C) 0.1 to 50 parts of a halide free quaternary ammonium surfactant containing at least 10 carbon atoms, and a sufficient amount of water to form an emulsion.Type: GrantFiled: July 20, 2011Date of Patent: April 28, 2015Assignee: Dow Corning CorporationInventors: Thomas Daniel Bekemeier, Anne-Lise Girboux, Marie-Agnes Leboucher, Scott B. Poplawski
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Publication number: 20150111851Abstract: This present disclosure is related to the field of 5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Inventors: Timothy Boebel, Kristy Bryan, Peter Lee Johnson, Beth Lorsbach, Kevin G. Meyer, W. John Owen, Michael T. Sullenberger, Jeffery D. Webster, Chenglin Yao
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Publication number: 20150105347Abstract: Shape-changing droplets, compositions comprising shape-changing droplets, methods of depositing benefit agents onto substrates using shape-changing droplets, and methods of making shape-changing droplets.Type: ApplicationFiled: October 17, 2013Publication date: April 16, 2015Inventors: Patrick Thomas SPICER, Marco CAGGIONI, Jessica LENIS-ABRIL, Alexandra Victoria BAYLES
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Publication number: 20150098973Abstract: Provided in various embodiments are compositions for topical application to the skin, comprising a silsesquioxane resin wax, at least one solid particulate with an average particle size greater than 1 micron, and one or more additional waxes.Type: ApplicationFiled: April 29, 2013Publication date: April 9, 2015Inventors: Gerald Brissette, Lok Ming Eva Li, Yihan Liu, Mary Kay Tomalia, Adrianna Urrutia-Gutierrez
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Publication number: 20150099719Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: ApplicationFiled: October 6, 2014Publication date: April 9, 2015Inventors: Shawn Stachel, Daniel V. Paone, Jing Li, Kausik Nanda
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Publication number: 20150099720Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.Type: ApplicationFiled: October 20, 2014Publication date: April 9, 2015Inventors: Lin Zhi, Robert I. Higuchi, E. Adam Kallel, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Daniel A. Ruppar, Bijan Pedram, Thomas Lot Stevens Lau, Todd A. Miller
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Patent number: 8999363Abstract: The present invention comprises methods and compositions for treating solid surfaces having antimicrobial and biocidal properties. Such surfaces are capable of controlling or killing a broad spectrum of biological agents, including viruses, bacteria and other microbial agents in solids, liquids or gases that subsequently contact the treated surface.Type: GrantFiled: November 15, 2006Date of Patent: April 7, 2015Assignee: Sishield Technologies, Inc.Inventor: Jacques Elfersy
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Patent number: 8999955Abstract: The invention relates to kinase inhibitors of the formula (I) in which —R1 to R4?H; ether or polyether, amino; NO2; NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; —R5=—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; N(R9,R10); —R5??H or a C1-C12 alkyl, —R6?H; R; (R or R?)3—Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R7 and R8?H, C1-C12 alkyl; —R9 and R10?H, R (or R?) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer.Type: GrantFiled: January 19, 2009Date of Patent: April 7, 2015Assignee: Centre National de la Recherche ScientifiqueInventors: Philippe Olivier Belmont, Laurent Meijer, Philip Cohen, Amaury Patin, Johann Bosson, Peter Gregory Goekjian