Polyhydroxy Patents (Class 514/669)
-
Patent number: 7060731Abstract: This application relates to the use of certain amines of formula (I) for combatting and preventing systemic and local complement activation, and in particular to the use of meglumine and derivatives and optionally salts thereof in combatting and preventing said activation. The amines are also of use in combatting activation of the kinin/kallikrein system or blood coagulation system.Type: GrantFiled: September 12, 2002Date of Patent: June 13, 2006Assignee: Amersham Health ASInventors: Anne Juelsrud, Gunn Ragnhild Hoigaard Bjerke
-
Patent number: 7052683Abstract: A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors and offering a complete and rapid control of incidental releases, and a complete protection of workers against airborne formaldehyde during the course of their work. The compound includes alkanolamine, for instantaneous reaction with formaldehyde, and for absorbing hydrogen sulfide and carbon dioxide from the air, and a human protein, which reacts with airborne formaldehyde and forms the major enzyme involved in formaldehyde oxidation in oral mucosa. The compound also contains cyclodextrins for inclusion complexation of all the components of spent and/or unused aqueous formaldehyde solutions.Type: GrantFiled: November 24, 2003Date of Patent: May 30, 2006Inventor: Gabriel J. Farkas
-
Patent number: 7008545Abstract: Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective amount of a nitrogenous compound activated by an oxidant and at least one non-oxidizing biocide to an aqueous system. The amount of activated nitrogenous compound and non-oxidizing biocide is selected to result in a synergistic biocidal effect.Type: GrantFiled: October 8, 2002Date of Patent: March 7, 2006Assignee: Hercules IncorporatedInventors: John M. Cronan, Jr., Michael J. Mayer
-
Patent number: 6986905Abstract: The present invention relates to a pharmaceutical composition and the method for the preparation thereof, The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium chloride, sodium bicarbonate, potassium chloride, magnesium sulfate, calcium chloride, calcium gluconate, and the like, and 3˜18% (w/v) of one or more substances selected from hydroxyethylstarch, dextran, carboxymethylstarch, polyvinyl-pyrrolidone, gelatin derivatives, and the like as well as the remainder of conventional injections, as long as sodium chloride is not less than 1.5% (w/v). The pharmaceutical composition of the present invention is used to treat and save the wounded and patients, as well as to treat shock, its advantages include safe and convenient use, rapid and good curative effect, long time maintenance, extensive uses and the like.Type: GrantFiled: November 15, 2000Date of Patent: January 17, 2006Inventor: Chaoying Zhao
-
Patent number: 6958146Abstract: Various exemplary compounds, compositions and methods are disclosed. An exemplary composition includes an insecticide comprising a formula weight greater than approximately 220 and a compound comprising an insect stimulant and a formula weight less than approximately 220. An exemplary method includes applying an insecticide comprising a formula weight greater than approximately 220 and applying a compound comprising an insect stimulant and a formula weight less than approximately 220. Exemplary compounds optionally include semiochemicals of insects, plants and/or animals. Other exemplary compounds, compositions and/or methods are also disclosed.Type: GrantFiled: May 28, 2003Date of Patent: October 25, 2005Assignee: Bug Buster Ltd.Inventors: Leonard R. Askham, Charles F. Dunham, Leonard D. Felix, Jr.
-
Patent number: 6932985Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and amine. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.Type: GrantFiled: October 8, 2002Date of Patent: August 23, 2005Assignee: Auburn UniversityInventor: Rodrigo Rodriguez-Kabana
-
Patent number: 6923990Abstract: The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate ion complex further complex with a primary, secondary or tertiary amine. These silver-ion super-complex compositions are stable in a saline environment and have improved solvent miscibility.Type: GrantFiled: April 23, 2003Date of Patent: August 2, 2005Inventor: Christopher Capelli
-
Patent number: 6852341Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds while maintaining beneficial soil organisms, by applying a compound comprised of a liquid medium and comprising an azide and an amino acid polymer. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.Type: GrantFiled: October 8, 2002Date of Patent: February 8, 2005Assignee: Auburn UniversityInventor: Rodrigo Rodriguez-Kabana
-
Patent number: 6833362Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: June 7, 2001Date of Patent: December 21, 2004Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
-
Patent number: 6830754Abstract: Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation.Type: GrantFiled: December 21, 1999Date of Patent: December 14, 2004Assignee: Kao CorporationInventors: Keiko Hasebe, Juri Sata, Yasuhiro Doi, Yoshinori Tamura, Masaki Inoue, Hiroshi Sonohara
-
Patent number: 6800661Abstract: Investigation of the activity of extracts of the clam Spisula polynyma has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.Type: GrantFiled: August 31, 1999Date of Patent: October 5, 2004Assignee: Board of Trustees of the University of IllinoisInventors: Kenneth L. Rinehart, Robert A. Warwick, Jesus Avila, Nancy L. Fregeau Gallagher, Dolores Garcia Gravalos, Glynn T. Faircloth
-
Publication number: 20040087662Abstract: The invention relates to the use of an accelerated lymphocyte homing agent, e.g. a 2-amino-1,3-propanediol derivative, in reducing delayed graft function in a recipient of organ or tissue transplant.Type: ApplicationFiled: August 20, 2003Publication date: May 6, 2004Inventors: Marc Bigaud, Volker Brinkmann, Tomasz Sablinski
-
Patent number: 6716882Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: April 23, 2002Date of Patent: April 6, 2004Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone
-
Publication number: 20040023885Abstract: Compositions and methods for islet neogenesis therapy comprising an EGF and a gastrin in combination with immune suppression, and for treating or preventing early stage diabetes with a gastrin/CCK receptor ligand and an immunosuppressant are provided.Type: ApplicationFiled: June 9, 2003Publication date: February 5, 2004Inventors: Stephen J. Brand, Antonio Cruz
-
Publication number: 20030195229Abstract: N-Substituted glucamine compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.Type: ApplicationFiled: December 17, 2002Publication date: October 16, 2003Applicant: Pharmacia CorporationInventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
-
Patent number: 6632805Abstract: A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article.Type: GrantFiled: May 7, 1996Date of Patent: October 14, 2003Assignee: Emory UniversityInventors: Lanny S. Liebeskind, Gary D. Allred
-
Patent number: 6599941Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellent is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: July 17, 2000Date of Patent: July 29, 2003Inventors: Lynn Sue James, Michael A. Siedman
-
Patent number: 6585991Abstract: Termite foods mixed together in a matrix suitable to be used as baits and attractants for termites are provided. This termite matrix is preferred by termites over naturally-occurring foods such as deadwood, trees and wood used in human constructions, and other known termite matrices. It comprises cellulose, water and termite-preferred nutrients. Methods of monitoring the presence of termites using such matrices, and methods of controlling termites using such matrices to deliver termite toxins are also provided.Type: GrantFiled: July 26, 2000Date of Patent: July 1, 2003Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Guadalupe M. Rojas, Juan A. Morales-Ramos, Edgar G. King, Jr.
-
Patent number: 6583182Abstract: This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune reponse, and in termination of pregnancy.Type: GrantFiled: November 30, 2001Date of Patent: June 24, 2003Assignee: Chelator LLCInventors: Harry S Winchell, Joseph Y Klein, Elliot D Simhon, Rosa L Cyjon, Ofer Klein, Haim Zaklad
-
Patent number: 6573242Abstract: The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following sequence: Dhc GN NDE SNI SFK EK (SEQ ID No 1) 1 5 10 The invention relates also to a composition comprising the mentioned peptide.Type: GrantFiled: June 16, 1999Date of Patent: June 3, 2003Assignee: Gesellschaft fuer BiotechnologischeInventor: Peter F. Muehlradt
-
Publication number: 20030083353Abstract: The present invention relates to compounds of formula (I): 1Type: ApplicationFiled: July 10, 2002Publication date: May 1, 2003Inventors: Heinrich Josef Schostarez, Robert A. Chrusciel
-
Patent number: 6541038Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.Type: GrantFiled: May 25, 2000Date of Patent: April 1, 2003Assignee: SDS Biotech K.K.Inventors: Keijitsu Tanaka, Hirobumi Aoki, Takashi Echigo
-
Patent number: 6521662Abstract: A ceramide-like compound having properties of the natural ceramides are represented by the following formula (I), and a method for producing the same , and a cosmetic composition containing the same as an active ingredient:Type: GrantFiled: January 19, 2001Date of Patent: February 18, 2003Assignee: Pacific CorporationInventors: Ho Sik Rho, Duck Hee Kim, Kil Joong Kim, Jae Won You, Hak Hee Kang, Ok Sub Lee, Jong Ho Park, Su Sun An, Eui Dong Son
-
Patent number: 6503945Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.Type: GrantFiled: January 11, 2002Date of Patent: January 7, 2003Assignee: Council of Scientific & Industrial ResearchInventors: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri
-
Publication number: 20030003099Abstract: A pharmaceutical combination comprising an accelerated lymphocyte homing agent in free form or in pharmaceutically acceptable salt form, and one or more compounds selected from the group consisting of an antibody to the IL-2 receptor, an immunosuppressive macrocyclic lactone and a soluble human complement inhibitor is used to treat or prevent insulin-producing cell graft rejection.Type: ApplicationFiled: June 7, 2002Publication date: January 2, 2003Inventors: Philip Lake, Claudy Mullon
-
Patent number: 6500857Abstract: Aging and sagging subcutaneous muscles are treated by first applying a composition containing at least one acetylcholine precursor and/or at least one compound exhibiting catecholamine activity to the overlying skin area, and then electronically stimulating the overlying skin area using electrical pulses in amounts sufficient to cause the subcutaneous muscles to contract. Preferred compositions contain from about 1% to about 10%, more narrowly from about 0.25% to about 5% by weight of an alkanolamine such as dimethylaminoethanol, the calcium salt of 2-aminoethanol phosphate or mixtures thereof and about from about 1% to about 10%, more narrowly from about 1% to 5% by weight of a compound exhibiting catecholamine activity such as tyrosine. Preferred electronic muscle stimulating devices deliver electrical pulses via electrodes in the fingertips of a compact device that fits on the hand.Type: GrantFiled: August 16, 2001Date of Patent: December 31, 2002Inventor: Nicholas V. Perricone
-
Patent number: 6441016Abstract: Wood preservatives contain a copper compound, an alkanolamine, a triazole, an emulsifier and/or a phosphonium compound and are used for impregnating wood.Type: GrantFiled: November 3, 1998Date of Patent: August 27, 2002Assignee: Dr. Wolman GmbHInventors: Reimer Goettsche, Hans-Volker Borck
-
Publication number: 20020058052Abstract: Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation.Type: ApplicationFiled: December 21, 1999Publication date: May 16, 2002Inventors: KEIKO HASEBE, JURI SATA, YASUHIRO DOI, YOSHINORI TAMURA, MASAKI INOUE, HIROSHI SONOHARA
-
Patent number: 6346516Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.Type: GrantFiled: March 25, 1999Date of Patent: February 12, 2002Assignee: Council of Scientific & Industrial ResearchInventors: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri
-
Patent number: 6337322Abstract: Preventives and remedies for intestinal mucosal disorders and diseases caused thereby which contain as the active ingredient a member selected from the group consisting of ethanolamine, phosphoethanolamine, phosphoglycerolethanolamine and salts thereof. These preventives and remedies inhibit shrinkage of the intestinal mucosa and have a beneficial effect on various functions of the intestinal tract.Type: GrantFiled: October 2, 2000Date of Patent: January 8, 2002Assignee: Meiji Milk Products Co., Ltd.Inventors: Hajime Sasaki, Kenji Mizumoto, Hisae Kume
-
Patent number: 6313177Abstract: A D-mannitol derivative selected from the group consisting of a compound of formula pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are the same or different and may each independently be selected from among alkyl and aryl (i.e. aromatic including aromatic like) groups. The D-mannitol derivatives may be used as HIV aspartyl protease inhibitors.Type: GrantFiled: April 30, 1999Date of Patent: November 6, 2001Assignee: Pharmacor Inc.Inventors: Gilles Sauvé, Abderrahim Bouzide
-
Patent number: 6274630Abstract: A method and pharmaceutical composition for inhibiting or preventing the intracellular biosynthesis of EIf5A by the administration to a human or non-human mammal in need thereof an amount of a polyamine analogue or salt thereof sufficient to deplete the supply of intracellular spermidine required for EIf5A biosynthesis.Type: GrantFiled: September 12, 1997Date of Patent: August 14, 2001Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
-
Patent number: 6214885Abstract: The use of polymers containing &bgr;-hydroxyalkylvinylamine units, as obtainable by reacting polymers containing vinylamine units with epoxides of the formula in which R is C2-C28 alkyl, phenyl, C1-C18 alkylphenyl or C2-C18 alkenyl, as biocides.Type: GrantFiled: March 7, 2000Date of Patent: April 10, 2001Assignee: BASF AktiengesellschaftInventors: Jürgen Tropsch, Dieter Zeller, Anton Negele, Norbert Mahr, Jürgen Decker
-
Patent number: 6203822Abstract: This invention relates to the use of gallium-containing compounds, to inhibit intracellular pathogens including pathogens that are members of the genus Mycobacteria, Legionella, Histoplasma, and Leishmania and to organisms causing chronic pulmonary infection such P. aeruginosa.Type: GrantFiled: September 3, 1996Date of Patent: March 20, 2001Assignee: University of Iowa Research FoundationInventors: Larry S. Schlesinger, Bradley E. Britigan
-
Patent number: 6139879Abstract: The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates to a chelate, that is an EDDHA (copper-ethylenediamine-di-o-hydroxyphenylacetic acid), combined with a heavy metal, including iron, tin, zinc, manganese, copper, and combinations thereof.Type: GrantFiled: August 31, 1999Date of Patent: October 31, 2000Assignee: Foliar Nutrients, Inc.Inventor: John B. Taylor
-
Patent number: 6130252Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: October 14, 1997Date of Patent: October 10, 2000Inventors: Lynn Sue James, Michael A. Siedman
-
Patent number: 6114396Abstract: A chemical composition for a sterilizer of disinfectant comprising, 2-bromo-2-nitropropan-1,3-diol, a halogen, a halogen compound or a halogentated compound, which is preferably iodine and 2,4-dichlorobenzyl alcohol. Optionally other constituents may be included in the composition such as for example surfactants. Different embodiments of the invention may be used as a cold sterilizer, gloved and ungloved hand sprays and a scrub for use as a skin scrub.Type: GrantFiled: February 20, 1998Date of Patent: September 5, 2000Assignee: Optident International Ltd.Inventor: Brian Louis Rens
-
Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
-
Patent number: 6008188Abstract: A cytokine activity enhancer comprising an ethanolamine derivative of the following general formula (I) or a salt thereof, or comprising it along with cytokine or a cytokine production promoter; and also a medicine for diseases with lowered cytokine activity, comprising, as the active ingredient, the cytokine activity enhancer: ##STR1## wherein R.sub.1 is H, --CH.sub.3, --CH.sub.2 CH(CH.sub.3)OH or --CH.sub.2 CH.sub.2 OH; R.sub.2 is H, --CH.sub.3, --CH.sub.2 CH.sub.3 or --COOH; and R.sub.3 is H, --CH.sub.3, --CH.sub.2 CH.sub.3 or --CH.sub.2 NH.sub.2.Type: GrantFiled: December 16, 1996Date of Patent: December 28, 1999Assignee: Kanebo LimitedInventors: Yuichi Oishi, Masaki Yoshida, Shintaro Inoue
-
Patent number: 6004958Abstract: The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction. Fructose-lysine-3-phosphate (FL3P) is then broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins), which are believed to be a cause of diabetic complications. Disclosed is a class of compounds which inhibit the action of FL3P kinase in the above-mentioned pathway.Type: GrantFiled: February 5, 1997Date of Patent: December 21, 1999Assignee: Fox Chase Cancer CenterInventors: Truman R. Brown, Francis Kappler, Benjamin Szwergold, Sundeep Lal, Bangying Su
-
Patent number: 5998475Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: March 20, 1997Date of Patent: December 7, 1999Inventors: Lynn Sue James, Michael A. Siedman
-
Patent number: 5997912Abstract: This invention relates to methods for using gallium-containing compounds to inhibit the growth of pathogenic P. aeruginosa in a mammal infected with the pathogen.Type: GrantFiled: October 30, 1997Date of Patent: December 7, 1999Assignee: University of Iowa Research FoundationInventors: Larry S. Schlesinger, Bradley E. Britigan
-
Patent number: 5993864Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.Type: GrantFiled: July 11, 1997Date of Patent: November 30, 1999Inventor: Robert D. Kross
-
Patent number: 5985239Abstract: The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.Type: GrantFiled: January 14, 1998Date of Patent: November 16, 1999Assignee: University of Kentucky Research FoundationInventors: Anwar A. Hussain, Bassam Tashtoush, Lewis W. Dittert
-
Patent number: 5985926Abstract: There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an effective amount of a compound that inhibits cellular signaling through a specific phospholipid-based cellular signaling and signal amplification pathway. The invention further provides a method for preventing or delaying clinical symptoms of a group of viral diseases wherein the viral disease is mediated by host cell viral replication. The invention provides an advantage by attacking host cellular signaling mechanisms to prevent the development of drug resistance from rapidly mutating viruses.Type: GrantFiled: February 10, 1997Date of Patent: November 16, 1999Assignee: Cell Therapeutics, Inc.Inventors: David W. Leung, Gail E. Underiner, Jack W. Singer
-
Patent number: 5973000Abstract: The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.Type: GrantFiled: June 3, 1997Date of Patent: October 26, 1999Assignees: Shiseido Company, Ltd., Takeda Chemical Industries, Ltd.Inventors: Tsunao Magara, Yoshiharu Tsuji, Chika Hamada, Yosuke Nakazawa, Eriko Takeoka, Masahiro Tajima, Masazumi Watanabe
-
Patent number: 5962533Abstract: Disclosed are polyamines having the formula: ##STR1## or salts or stereoisomers thereof wherein R.sub.1 -R.sub.4 and ALK.sub.1 -ALK.sub.3 are as defined in the specification. Pharmaceutical compositions and therapeutic methods of treatment utilizing the compounds are also disclosed.Type: GrantFiled: February 6, 1996Date of Patent: October 5, 1999Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
-
Patent number: 5952380Abstract: A pharmaceutical composition for treating diarrhea comprising an anti-diarrhea effective amount of conagenin or a salt thereof, and a pharmaceutically acceptable carrier. The pharmaceutical composition is particularly useful against diarrhea caused by the administration of cancer chemotherapeutic agents.Type: GrantFiled: March 27, 1997Date of Patent: September 14, 1999Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Taino Pharmaceutical Co., Ltd., Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Masaaki Ishizuka, Kenji Maeda, Tomio Takeuchi, Toshiyuki Toko, Tadayoshi Shiraishi
-
Patent number: 5916924Abstract: The present invention discloses a method for the treatment of liver diseases, comprising administering an effective amount of an aminoalcohol of the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a phosphono group, R.sup.2 represents a hydrogen atom or a group--(CH.sub.2).sub.n --OR.sup.1, and n represents an integer between 2 and 5 inclusive. The present invention also relates to the use of the compound in the manufacture of a remedy for the treatment of liver diseases. This compound exhibits hepatocyte proliferation activity and liver disorder restoring effect, and thus is useful for the treatment of acute hepatitis, chronic hepatitis, hepatic cirrhosis, etc.Type: GrantFiled: November 17, 1997Date of Patent: June 29, 1999Assignee: Meiji Milk Products Co., Ltd.Inventors: Hajime Sasaki, Atsushi Nemoto, Hisae Kume, Hiroshi Tsuboi, Kenji Mizumoto, Naommy Takahashi, Masayuki Uchida
-
Patent number: 5908867Abstract: A method of reducing hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a compound that inhibits the formation of glycoproteins, proteglycans, or glycosaminoglycans in an amount effective to cause a reduction in hair growth.Type: GrantFiled: July 18, 1996Date of Patent: June 1, 1999Inventors: James P. Henry, Gurpreet S. Ahluwalia, Edward Kaszynski, Douglas Shander