Polyhydroxy Patents (Class 514/669)
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Patent number: 5863563Abstract: Methods and compositions for the treatment of the symptoms of a patient who has a pulmonary condition associated with an inhibition of surfactant secretion by type II alveolar cells are described. The method of treatment involves causing a patient to inhale an amount of a pH-raising buffer effective to raise the pH of the aqueous fluid in the microenvironment of the type II alveolar cell lumenal surface, thereby inducing an increase in the rate of surfactant secretion by type II alveolar cells.Type: GrantFiled: October 20, 1994Date of Patent: January 26, 1999Assignee: AlphaGene Inc.Inventor: George Scheele
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Patent number: 5801202Abstract: Disclosed is an amine derivative represented by the following formula (1) or an acid addition salt thereof: ##STR1## wherein R.sup.1 represents a group ##STR2## a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R.sup.2 is a hydrogen atom or C1-C3 alkyl group which may be substituted by one or more hydroxyl groups, m is an integer falling in the range from 3 to 5 inclusive, and n is an integer falling in the range from 9 to 11 inclusive. Also, intermediates useful in the manufacture of the amine derivative (1), compositions for external application to the skin containing the amine derivative, and keratinization improvers containing the amine derivative as an active component are described. The compound (1) has excellent keratinization improving action, pigmentation preventing action, etc.Type: GrantFiled: May 30, 1997Date of Patent: September 1, 1998Assignee: Kao CoprorationInventors: Taketoshi Fujimori, Hiroshi Kusuoku, Akira Yamamuro, Yukihiro Yada, Kazuhiko Higuchi, Genji Imokawa, Naoki Kondo, Yoshinori Masukawa, Hajime Tokuda, Hisashi Tsujimura
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Patent number: 5801181Abstract: Therapeutic compounds have the formula:(X)j--(core moiety),J being an integer from one to three, the core moiety having at least one, five- to seven-membered ring and X being a racemic mixture, R or S enantiomer, slovate, hydrate, or salt of: ##STR1## *C is a chiral carbon atom, n is an integer from one to four (preferably from one to three), one or more carbon atoms of (CH.sub.2).sub.n may be substituted by a keto or hydroxy group, and m is an integer from one to fourteen. Independently, R.sub.1 and R.sub.2 may be a hydrogen, a straight or branched chain alkane or alkene of up to twelve carbon atoms in length, or --(CH.sub.2).sub.w R.sub.5, w being an integer from two to fourteen and R.sub.5 being a mono-, di- or tri-substituted or unsubstituted aryl group, substituents on R.sub.5 being hydroxy, chloro, fluoro, bromo, or C.sub.1-6 alkoxy. Or jointly, R.sub.1 and R.sub.Type: GrantFiled: June 7, 1995Date of Patent: September 1, 1998Assignee: Cell Therapeutics, Inc.Inventors: John Michnick, Gail E. Underiner, J. Peter Klein, Glenn C. Rice
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Patent number: 5753701Abstract: The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.Type: GrantFiled: October 25, 1996Date of Patent: May 19, 1998Assignee: University of KentuckyInventors: Anwar A. Hussain, Bassam Tashtoush, Lewis W. Dittert
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Patent number: 5723497Abstract: The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.Type: GrantFiled: September 18, 1995Date of Patent: March 3, 1998Assignee: Kao CorporationInventors: Yukihiro Ohashi, Yukihiro Yada, Yoshinori Takema, Taketoshi Fujimori, Akira Kawamata, Hiroyuki Ohsu, Kazuhiko Higuchi, Genji Imokawa, Hiroshi Kusuoku, Ayumi Ogawa, Tsutomu Fujimura
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Patent number: 5681864Abstract: A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.Type: GrantFiled: December 6, 1996Date of Patent: October 28, 1997Assignee: Kao CorporationInventors: Yukihiro Ohashi, Taketoshi Fujimori, Minoru Nagai, Akira Kawamata, Yukihiro Yada, Kazuhiko Higuchi, Genji Imokawa, Yoshinori Takema, Yukiko Sakaino, Ayumi Ogawa, Tsutomu Fujimura
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Patent number: 5681859Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: September 6, 1995Date of Patent: October 28, 1997Assignee: Lynn Sue JamesInventors: Lynn Sue James, Michael A. Siedman
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Patent number: 5677341Abstract: An acidic emulsion comprising a lipoid dispersed in an aqueous phase, a cationic sphingolipid, and a stabilizing amount of non-ionic surfactant and cholesterol is provided, along with the method of administering the emulsion.Type: GrantFiled: July 16, 1996Date of Patent: October 14, 1997Assignees: Pharmacia & Upjohn Aktiebolag, Eli Lilly and CompanyInventor: Robert T. Lyons
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Patent number: 5614558Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: June 2, 1995Date of Patent: March 25, 1997Assignee: Lynn Sue JamesInventors: Lynn S. James, Michael A. Siedman
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Patent number: 5583160Abstract: N-methylated sphingosine used to induce apoptosis.Type: GrantFiled: December 14, 1994Date of Patent: December 10, 1996Assignee: The Biomembrane InstituteInventors: Yasuyuki Igarashi, Sen-Itiroh Hakomori
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Patent number: 5552445Abstract: A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.Type: GrantFiled: March 23, 1994Date of Patent: September 3, 1996Assignee: Kao CorporationInventors: Yukihiro Ohashi, Taketoshi Fujimori, Minoru Nagai, Akira Kawamata, Yukihiro Yada, Kazuhiko Higuchi, Genji Imokawa, Yoshinori Takema, Yukiko Sakaino, Ayumi Ogawa, Tsutomu Fujimura
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Patent number: 5534553Abstract: This invention relates to the use of fatty amino alcohols or derivatives thereof as drugs for the consequences of drug dependency.Type: GrantFiled: March 7, 1994Date of Patent: July 9, 1996Inventor: Wilhelm Hoerrmann
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Patent number: 5470878Abstract: Therapeutic compounds have the formula:(X)j-(non-cyclic core moiety),j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate, hydrate, or salt of: ##STR1## *C is a chiral carbon atom, n is an integer from one to four (preferably from one to three), one or more carbon atoms of (CH.sub.2).sub.n may be substituted by a keto or hydroxy group, and m is an integer from one to fourteen. Independently, R.sub.1 and R.sub.2 may be a hydrogen, a straight or branched chain alkane or alkene of up to twelve carbon atoms in length, or --(CH.sub.2).sub.w R.sub.5, w being an integer from two to fourteen and R.sub.5 being a mono-, di- or tri-substituted or unsubstituted aryl group, substituents on R.sub.5 being hydroxy, chloro, fluoro, bromo, or C.sub.1-6 alkoxy. Or jointly, R.sub.1 and R.sub.2 form a substituted or unsubstituted, saturated or unsaturated heterocyclic group having from four to eight carbon atoms, N being a hetero atom. R.sub.Type: GrantFiled: December 8, 1993Date of Patent: November 28, 1995Assignee: Cell Therapeutics, Inc.Inventors: John Michnick, Gail E. Underiner, J. Peter Klein, Glenn C. Rice
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Patent number: 5436241Abstract: The composition contains: an antiinflammatory effective amount of piroxicam; an amount of tetrahydroxypropylethylenediamine sufficient to solubilize the piroxicam in the composition; an amount of C.sub.2 -C.sub.6 alkylene glycol, or mixture thereof, sufficient to detackify the composition and provide humectancy; about 0.2% to about 2% carbomer; about 30% to about 60% C.sub.2 -C.sub.4 alkanol; and water qs to 100%. Hydroxypropylcellulose can be added to the composition.Type: GrantFiled: January 14, 1994Date of Patent: July 25, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Chung Shin, Luc Bossuyt
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Patent number: 5278178Abstract: This invention relates to synergistic antimicrobial and biocidal compositions comprising 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one and one or more commercial biocides for more effective, and broader control of microorganisms in various industrial systems.Type: GrantFiled: April 29, 1993Date of Patent: January 11, 1994Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5246913Abstract: This invention relates to synergistic antimicrobial and biocidal compositions comprising 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one and one or more commercial biocides for more effective, and broader control of microorganisms in various industrial systems.Type: GrantFiled: October 30, 1992Date of Patent: September 21, 1993Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5229422Abstract: An extemporaneous kit of pharmaceutical substance-containing fat emulsion which consists of a fat emulsion and (a) a pharmaceutical substance composition containing pharmaceutical substance and at least one solvent selected from the group consisting of water, liquid polyalkylene glycols, liquid alkylethanolamines, and liquid polyhydric alcohols, or (b) a pharmaceutical substance composition containing pharmaceutical substance and saccharides and/or 30 amino acids as an excipient, and a process for preparation of a pharmaceutical substance-containing fat emulsion therefrom.Type: GrantFiled: June 13, 1991Date of Patent: July 20, 1993Assignee: Teijin LimitedInventors: Ken Takahashi, Yuji Makino, Yoshiki Suzuki, Tatsuyuki Naruchi
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Patent number: 5223515Abstract: An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group; R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, is provided by dissolving the compound in at least one of ethanol, propylene glycol and polyethylene glycol; or by dissolving the freeze-dried material of an alkaline aqueous solution of the compound in a mixture of an acidic substance and at least one of the above solvents.Type: GrantFiled: August 4, 1992Date of Patent: June 29, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasushi Mikura, Akihiro Nagai, Hisayoshi Shimizu
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Patent number: 5023008Abstract: Novel nonionic antimicrobial amine glycidol compounds which may be used in cleaning compositions with anionics, nonionics or cationic surfactants as cleaning agents or a preservative in water-based functional fluids or surface coating compositions are represented by the formula: ##STR1## wherein R represents an alkyl group having from about 8 to about 18 carbon atoms and mixtures thereof,Y represents H, ##STR2## or R', and mixtures thereof; R' represents an alkyl group, the sum total of carbon atoms in R+R' being from about 8 to about 18;n is from about 1 to about 6; andm+n are from about 2 to about 12;wherein the molar ratio of amine glycidol compound to surfactant is from about 10:1 to about 1:10.Type: GrantFiled: November 17, 1989Date of Patent: June 11, 1991Assignee: Olin CorporationInventors: Michael Scardera, Frank R. Grosser
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Patent number: 4985245Abstract: A medical composition which contains a tissue Plasminogen Activator (tPA) in combination with meglumine or a salt thereof.Type: GrantFiled: November 3, 1989Date of Patent: January 15, 1991Assignee: Eisai Co., Ltd.Inventors: Fumio Kakimoto, Naoki Asakawa, Yasuo Ishibashi, Yasuo Miyake
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Patent number: 4952567Abstract: A process which comprises administering an antagonist of protein kinase C and/or the insulin receptor tyrosine kinase to a mammal in an amount therapeutically effective to inhibit lipogenesis in the mammal.Type: GrantFiled: July 8, 1988Date of Patent: August 28, 1990Assignee: City of HopeInventors: Pierre DeMeyts, Jean Smal, Yoko Fujita-Yamaguchi
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Patent number: 4937269Abstract: Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are substituted alkyl (C.sub.2 -C.sub.6) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R.sub.3 and R.sub.4 are alkyl or substituted alkyl (C.sub.1 -C.sub.6), and n=2 to about 6. Preferably R.sub.1 through R.sub.4 are the same and are 2-hydroxyalkyl.Type: GrantFiled: October 14, 1988Date of Patent: June 26, 1990Assignee: University of AkronInventors: Daniel J. Smith, Sanjay R. Patel, Edwin C. Rowland
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Patent number: 4923887Abstract: Antimicrobially active liquid composition formulation which comprises 1,2-benzisothiazolin-3-one and at least one amine-oxyethylate of the formula ##STR1## wherein R is alkyl or alkenyl each having 2 to 22 carbon atoms and the sum of m and n is a number from 2 to 30 is used as an improved biocide to preserve and protect aqueous solutions from infestation with micro-organisms.Type: GrantFiled: August 25, 1988Date of Patent: May 8, 1990Assignee: Cassella AktiengesellschaftInventors: Wolfgang Bauer, Hans-Walter Bucking, Karl-Heinz Wallhausser
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Patent number: 4829083Abstract: The invention relates to the stabilization of mercury-containing preservatives in liquid or gel-form ophthalmic medicaments. This stabilization against chemical decomposition after the preservative has become deposited on the inner walls of the plastics containers is achieved by adding to the formulation 2-amino-2-hydroxymethyl-1,3-propanediol or a homologue thereof having up to 10 carbon atoms.Type: GrantFiled: April 14, 1987Date of Patent: May 9, 1989Assignee: Dispersa AGInventor: Johann Doulakas
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Patent number: 4778825Abstract: Quadrol has been found to stimulate macrophage activity in warm blooded animals. As a consequence, Quadrol may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol may be applied topically, e.g., as the active agent in a wound dressing.Type: GrantFiled: August 29, 1986Date of Patent: October 18, 1988Assignee: The University of AkronInventors: Daniel J. Smith, Sanjay R. Patel, Edwin C. Rowland
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Patent number: 4655815Abstract: The present invention is directed to a synergistic antimicrobial admixture comprising 2-bromo-2-bromomethylglutaronitrile and a formaldehyde donor.Type: GrantFiled: March 27, 1985Date of Patent: April 7, 1987Assignee: Calgon CorporationInventor: John A. Jakubowski