Ether Doai Patents (Class 514/715)
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Publication number: 20040077728Abstract: Disclosed are retiferol derivatives of formula (I): wherein X is >C═CH2 or —CH2—; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is —O(CH2)3—, —(CH2)2-(1,2-C6H4)—, —CH═CH—(1,2-C6H4)—, —C═C—(1,2C6H4)—, —(CH2)2—CO—, —CH2—O—CO—, —CH2NHCO—, or —CH2NHCOCH2—; R1 is C1-C5-alkyl; R2 and R3 are independently of each other alkyl or perfluoroalkyl; and R4 is hydrogen, hydroxy, C1-C5-alkyl or C1-C5-alkyl or C1-C5-alkoxy; the use of such compounds to treat or present hyperproliferative skin diseases such as psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; neoplastic diseases; disorders of the sebaceous glands such as acne and seborrhoic dermatitis; the use of these compounds in reversing the conditions associated with photodamage, particularly for the oral or topical treatment of the skin damaged through sun exposurType: ApplicationFiled: December 4, 2003Publication date: April 22, 2004Inventors: Pierre Barbier, Franz W Bauer, Peter Mohr, Marc Muller, Wolfgang Pirson
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Patent number: 6716876Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.Type: GrantFiled: February 28, 2002Date of Patent: April 6, 2004Assignee: Allergan, Inc.Inventor: Robert M. Burk
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Patent number: 6677385Abstract: Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 5-carbon sugar, sugar alcohol, or lactic acid are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol. A process for the synthesis of PG from lactate or lactic acid is also described.Type: GrantFiled: August 6, 2002Date of Patent: January 13, 2004Assignee: Battelle Memorial InstituteInventors: Todd A. Werpy, John G. Frye, Jr., Alan H. Zacher, Dennis J. Miller
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Patent number: 6670397Abstract: This invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune diseases.Type: GrantFiled: May 24, 2001Date of Patent: December 30, 2003Inventor: Steven Baranowitz
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Patent number: 6660288Abstract: The use of specific perfume ingredients, e.g. tricyclodecenyl allyl ether, to repel insects. The perfume ingredients may be used in a composition comprising from 0.1 to 40 percent by weight of one or more of the perfume ingredients. Preferably at least one of the perfume ingredients has a hydrophobicity such that the common logarithm of the octanol-water partition coefficient, log P, of the perfume ingredient is in the range 1.0 to 6.0.Type: GrantFiled: May 29, 2001Date of Patent: December 9, 2003Assignee: Quest International B.V.Inventors: John Martin Behan, Richard Arthur Birch
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Patent number: 6645978Abstract: Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.Type: GrantFiled: March 23, 2001Date of Patent: November 11, 2003Assignee: Alcon, Inc.Inventors: Daniel A. Gamache, Gustav Graff, Mark R. Hellberg, Peter G. Klimko, John M. Yanni
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Patent number: 6635672Abstract: The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane or clerodane type: wherein R1=H, C1 to C3 alkyl or C1 to C3 acyl.Type: GrantFiled: September 24, 2001Date of Patent: October 21, 2003Assignee: Bionorica AGInventors: Wolfgang Wuttke, Hubertus Jarry, Michael Popp, Volker Christoffel, Barbara Spengler
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Patent number: 6620418Abstract: An antiseptic/antifungal agent comprising 2,2-dialkyl-1,3-propanediol represented by the formula (I): wherein R1 and R2 can either be identical or different from each other, and both denote an alkyl group with a carbon number of 1-4, and an endermic liniment containing the same. In addition, an endermic liniment containing 3-methyl-3-methoxybutanol and 1,2-pentanediol, and an endermic liniment containing 3-methyl-3-methoxybutanol and 2-phenoxyethanol, is provided.Type: GrantFiled: March 29, 2000Date of Patent: September 16, 2003Assignee: Shiseido Company, Ltd.Inventors: Shigeyuki Ogawa, Yoshio Asaka
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Publication number: 20030144254Abstract: The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; 1Type: ApplicationFiled: January 16, 2003Publication date: July 31, 2003Applicant: Allergan Sales, Inc.Inventors: Robert M. Burk, Mark Holoboski, Mari F. Posner
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Patent number: 6596772Abstract: The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.Type: GrantFiled: August 25, 2000Date of Patent: July 22, 2003Assignee: Sugen, Inc.Inventors: Ping Huang, Chung Chen Wei, Peng Cho Tang, Chris Liang, John Ramphal, Bahija Jallal, John Biltz, Sharon Li, Matt Mattson, Gerald McMahon, Marcel Koenig
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Publication number: 20030130239Abstract: The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives.Type: ApplicationFiled: October 29, 2002Publication date: July 10, 2003Applicant: Allergan, Inc.Inventors: Robert M. Burk, Mark Holoboski, Mari F. Posner
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Patent number: 6562782Abstract: The present invention related to an oligocycloalkanoid compound comprising formula (I) wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O—, carbonyl, oxygen, or sulfur; X and Y are independently hydrogen, hydroxy, alkyl, or in combination an electrophilic group; and R1 through R10 are independently hydrogen, hydroxy, alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, N-, S-, or O-heterocycles, fused or multi-ring aryl with or without hetero ring members, arylalkyl, arylalkenyl, arylalkynyl, alkylphenyl, alkenylphenyl, alkynylphenyl, alkoxy, alkenyloxy, alkynyloxy, substituted or unsubstituted aryloxy, substituted or unsubstituted arylalkoxy, alkylacyl, alkenylacyl, alkynylacyl, arylacyl, aroyl, alkylaroyl, aminoaroyl, aminoalkylacyl, aminoalkyl, aminoalkenyl, aminoalkynyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, dialkylamino, dialkenylamino, dialkynylamino, arylalkylamino, arylalkType: GrantFiled: May 10, 2000Date of Patent: May 13, 2003Assignee: University of RochesterInventors: Benjamin L. Miller, Robert D. Hubbard
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Patent number: 6548715Abstract: A compound of the formula I: in which P is hydrogen or alkyl; Y and Y′ are each hydrogen or, when taken together, represent a group ═CH2; W and W′ are each hydrogen; X is selected from the group consisting of a hydroxyalkyl, a hydroxyalkoxy, an alkoxy optionally comprising an epoxide function, a hydroxyalkene, a hydroxyalkadiene, a hydroxyalkyne and isomeric forms thereof; and a) either R1 and R3 or R′3 form a saturated 5- or 6-membered carbocyclic ring and R2, R′2, R3 or R′3, R4, R′4, R5 and R′5 are each independently hydrogen or alkyl; or b) R2 or R′2 and R4 or R′4 form a saturated 5- or 6-membered carbocyclic ring, and R1, R2 or R′2, R3, R′3, R4 or R′4, R5 and R′5 are each independently hydrogen or alkyl; or c) R3 or R′3 and R5 or R′5 form a saturated or unsaturated 5- or 6-membered carbocyclic ring, and R1, R2, R′2, R3 or R′3, R4, R′4, and R5 or R′5 are each indepType: GrantFiled: October 28, 1999Date of Patent: April 15, 2003Assignee: Laboratoire Theramex S.A.Inventors: Roger Bouillon, Maurits Vandewalle, Pierre Jean De Clercq
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Patent number: 6548552Abstract: An absorbent article, particularly a tampon having additives that reduce toxic shock syndrome toxin (TST-1) production is disclosed. The tampon has a combination of an effective amount of at least one oxygen inhibiting agent and an effective amount of at least one surface active agent applied to: the surface of the absorbent tampon material; the surfaces of the fibers comprising the tampon; to the tampon applicator; or any combination of the foregoing. The effective amounts of the oxygen inhibiting agent and the surface active agent are sufficient to reduce the toxin production at lease about 50%, but do not negatively affect the wearer's normal vaginal flora.Type: GrantFiled: September 10, 1998Date of Patent: April 15, 2003Assignee: The Brigham and Women's Hospital, Inc.Inventors: Robert L. Deresiewicz, Dennis L. Kasper
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Patent number: 6528049Abstract: Novel bisexual attractants for lepidopterous insect pests isolated from pears or apples. A method for monitoring and control of codling moth and other species of Lepidoptera comprising a lure and kill, mating disruption or mass trapping strategy. A method of using a formulation containing the bisexual attractants with or without an insecticide and/or pheromone for control of the insect pests.Type: GrantFiled: April 23, 2001Date of Patent: March 4, 2003Assignees: Trece, Inc., The United States of America as represented by the Secretary of AgricultureInventors: Douglas M. Light, Clive A. Henrick
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Patent number: 6515029Abstract: An absorbent article having a bodyside liner includes a hydrophilic lotion formulation on the outer bodyfacing surface thereof. The hydrophilic lotion formulation comprises from about 10 to about 90 weight percent of a hydrophilic solvent, from about 5 to about 90 weight percent of a high molecular weight polyethylene glycol, and from about 0 to about 60 weight percent of a fatty alcohol. The hydrophilic lotion formulation has a reduced adverse effect on the absorbent and liquid uptake properties of the liner and the absorbent body when compared to conventional lipophilic or hydrophobic lotion formulations. The hydrophilic lotion formulation acts as a lubricant to reduce the abrasion of the skin caused by the liner and also transfers to the skin to provide improved skin health.Type: GrantFiled: April 23, 1999Date of Patent: February 4, 2003Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Duane Gerard Krzysik, David Charles Musil, Frank Andrew Rosch, III, Gordon Allen Shaw, Diane Michele Underhill, Jeffrey Michael Hockersmith
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Patent number: 6506799Abstract: The present invention relates to methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension comprising administering a composition comprising an ether compound.Type: GrantFiled: March 31, 2000Date of Patent: January 14, 2003Assignee: Esperion Therapeutics, Inc.Inventor: Jean-Louis Henri Dasseux
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Patent number: 6500416Abstract: There are described a flowable composition for controlling harmful insects and representatives of the order Acarina, comprising at least one pesticidally active compound, one or more signal substances selected from the group consisting of pheromones, kairomones and attractants, a UV absorber or a UV absorber mixture and, if appropriate, one or more additives selected from the group consisting of viscosity-regulating thickeners, fillers, solvents and other formulation auxiliaries, which composition comprises 40 to 98% by weight of the UV absorber or the UV absorber mixture, 0.01 to 30% by weight of one or more signal substance(s) and 0.1 to 20% by weight of one or more pesticidally active compound(s) of the formulae (I) to (V) as specified, and a method of controlling harmful insects and representatives of the order Acarina using this composition.Type: GrantFiled: February 22, 2001Date of Patent: December 31, 2002Assignee: Syngenta Crop Protection, Inc.Inventors: Dieter Hofer, Max Angst, Pierre-Joseph Charmillot
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Patent number: 6464960Abstract: The aerosol hair spray composition contains a hair-setting polymer in a solvent/propellant system containing a C1 to C4 alcohol, water, a cosolvent selected from among acetone and methyl acetate or a mixture thereof, and aerosol propellants, particularly a combination of dimethyl ether and a fluorocarbon. The composition according to the invention makes it possible to produce low-cost, water-containing aerosol hair sprays with a reduced VOC content and at the same time to optimize their use properties.Type: GrantFiled: July 13, 2000Date of Patent: October 15, 2002Assignee: Wella AktiengesellschaftInventors: Liane Staehle, Ulrich Herfurt
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Patent number: 6465421Abstract: The growth of body and/or head/cranial hair on mammalian organisms, for example humans, is modulated by administering thereto, whether topically and/or systemically, therapeutically effective amounts of at least one lipoxygenase or cyclooxygenase inhibitor, or at least one lipoxygenase or cyclooxygenase stimulator, preferably in the presence of at least one lipoxygenase/cyclooxygenase substrate or precursor thereof; when a hair-growth or hair loss-limiting response is sought to be elicited, a lipoxygenase inhibitor and/or cyclooxygenase stimulator is administered (conversely, to reduce or prevent hair growth, a lipoxygenase stimulator and/or cyclooxygenase inhibitor is administered).Type: GrantFiled: June 30, 1997Date of Patent: October 15, 2002Assignee: Societe l'Oreal S.A.Inventors: Albert Duranton, Olivier De Lacharriere
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Publication number: 20020142015Abstract: A warming composition which produces an excellent warming effect of long duration with no or little skin irritation, a fragrance composition comprising the warming composition, and cosmetics, toiletries, bath additives, and pharmaceuticals containing the warming composition or the fragrance composition.Type: ApplicationFiled: December 10, 2001Publication date: October 3, 2002Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Hiroyasu Kumamoto, Hideaki Ohta
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Patent number: 6444230Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1)(R2)(R3)N→O (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.Type: GrantFiled: November 20, 2000Date of Patent: September 3, 2002Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques SeppicInventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
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Patent number: 6444709Abstract: The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.Type: GrantFiled: February 7, 2000Date of Patent: September 3, 2002Assignee: Galderma Research & Development S.N.C.Inventors: Philippe Diaz, Jean-Michel Bernardon
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Publication number: 20020120014Abstract: Acyclic ethers can be used as rhinologically active substances. In the regions of the mouth, the throat and the airways they produce a refreshing and clearing feeling.Type: ApplicationFiled: November 21, 2001Publication date: August 29, 2002Inventors: Horst Surburg, Arnold Machinek, Hubert Loges
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Patent number: 6414022Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.Type: GrantFiled: July 31, 2001Date of Patent: July 2, 2002Assignee: Allergan Sales, Inc.Inventor: Robert M. Burk
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Publication number: 20020077367Abstract: A process for producing highly pure 3-l-menthoxypropane-1,2-diol safely and efficiently, and an intermediate to be used in the process. 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the following general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid to produce a novel 1-halogeno-3-l-menthoxypropan-2-ol represented by the following general formula (II), then, epoxidating it with a base in the presence of a phase transfer catalyst to produce a 1,2-epoxy-3-l-menthoxypropane represented by the chemical formula (III), and further hydrolyzing it.Type: ApplicationFiled: September 26, 2001Publication date: June 20, 2002Inventors: Akira Amano, Teruyoshi Akiyama, Takashi Miura, Toshimitsu Hagiwara
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Patent number: 6399664Abstract: A method for treating malignant cells such as leukemia or chronic myeloid leukemia, in a mammal, comprising of administering to the mammal a leukemia therapeutically effective amount of reactive oxygen intermediates. A method of treating cancer in a mammal with cancer and modulating the mammal's immune system, comprising of administering to the mammal in need thereof a cancer therapeutically effective amount of reactive oxygen intermediates. A method of treating leukemia in a mammal with leukemia, comprising of administering to the mammal in need thereof a leukemia therapeutically effective amount of ozone into the mammal's blood and a leukemia therapeutically effective amount of ether lipids.Type: GrantFiled: December 3, 1997Date of Patent: June 4, 2002Inventor: Lisa Marlene Jefferys Smith
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Publication number: 20020049257Abstract: The present invention relates to an antibacterial composition containing a compound of formula I 1Type: ApplicationFiled: August 13, 2001Publication date: April 25, 2002Inventor: Andreas Natsch
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Publication number: 20020045584Abstract: A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-linked compound comprises a first acyclic isoprenoid molecule linked via an ether linkage to a second molecule, wherein the second molecule can suppress tumor formation.Type: ApplicationFiled: July 16, 2001Publication date: April 18, 2002Inventors: Charles E. Elson, Manfred Jung, Huanbiao Mo
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Publication number: 20020035146Abstract: The present invention relates to the use of certain compounds, known to inhibit the response of plants to ethylene, for the control of phytopathogenic fungi. The compounds are substituted cyclopropenes.Type: ApplicationFiled: July 17, 2001Publication date: March 21, 2002Inventor: David Hamilton Young
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Publication number: 20020032177Abstract: The present invention relates to the use of D-chiro-inositol (DCI) as a regulator of hypothalamic gene expression and, more particularly, to the use of DCI and derivatives and metabolites thereof to treat neuroendocrine impairments such as obesity, polycystic ovarian syndrome (PCOS), impaired regulation of hormones during aging and to correct such neuroendocrine impairments and associated functions.Type: ApplicationFiled: April 30, 2001Publication date: March 14, 2002Applicant: Insmed Pharmaceuticals, Inc.Inventors: Geoffrey Allan, Charles V. Mobbs
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Patent number: 6344485Abstract: Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.Type: GrantFiled: June 18, 1999Date of Patent: February 5, 2002Assignee: Pfizer Inc.Inventors: Kimberly O. Cameron, Bruce A. Lefker
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Patent number: 6342499Abstract: The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective amount of a mitochondrial electron transport inhibitor or a pyrimidine compound of formula I.Type: GrantFiled: July 12, 1999Date of Patent: January 29, 2002Assignee: BASF AktiengesellschaftInventors: Bruce Christian Black, William R. Baumbach, Michael P. Beluch
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Publication number: 20020006967Abstract: The present invention includes methods for treatment and prophylaxis of eye disorders and injuries, particularly treatment and prophylaxis of ocular neovascularization and disorders, especially a vasculopathy that affects retinal or chorodial vessels. The methods of the invention in general comprise administration of a therapeutically effective amount of a compound that inhibits farnesyl-protein transferase to a subject suffering from or susceptible to ocular neovascularization or associated disorder.Type: ApplicationFiled: June 18, 1998Publication date: January 17, 2002Inventor: PETER A. CAMPOCHIARO
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Publication number: 20020002150Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.Type: ApplicationFiled: July 31, 2001Publication date: January 3, 2002Applicant: ALLERGAN SALES, INC.Inventor: Robert M. Burk
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Publication number: 20010049395Abstract: A method for treating malignant cells such as leukemia or chronic myeloid leukemia, in a mammal, comprising of administering to the mammal a leukemia therapeutically effective amount of reactive oxygen intermediates. A method of treating cancer in a mammal with cancer and modulating the mammal's immune system, comprising of administering to the mammal in need thereof a cancer therapeutically effective amount of reactive oxygen intermediates. A method of treating leukemia in a mammal with leukemia, comprising of administering to the mammal in need thereof a leukemia therapeutically effective amount of ozone into the mammal's blood and a leukemia therapeutically effective amount of ether lipids.Type: ApplicationFiled: December 3, 1997Publication date: December 6, 2001Inventor: LISA MARLENE JEFFREYS SMITH
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Patent number: 6309633Abstract: The invention provides a drug-oligomer conjugate having the following general formula: wherein D is a therapeutic drug moiety; H and H′ are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the —H′, —L and —H—L substituents; the H—L bond(s) are hydrolyzable and the D—L′ bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p isType: GrantFiled: June 19, 1999Date of Patent: October 30, 2001Assignee: Nobex CorporationInventors: Nnochiri Ekwuribe, Muthukumar Ramaswamy, Jayanthi Sethuraman Rajagopalan
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Patent number: 6300377Abstract: The present invention relates to a composition in liquid dosage form of coenzyme Q or ubiquinone which can be formulated into cosmetic, dietary supplement or pharmaceutical dosage form for administration to patients. The dosage form comprises an effective amount of coenzyme Q or ubiquinone ranging from about 0.05% to about 15%, more preferably about 1% to about 10.0% by weight of the composition in combination with a polysorbate surfactant such as a Tween™, surfactant, a vegetable oil or triglyceride, in further combination with a glyceryl ester in amounts effective to produce a liquid dosage form. Optional additives include a phospholipid such as hydroxylated lecithin, among others such as tocopherols or tocopherol esters effective to solubilize the ubiquinone in combination as well as other bioactive agents. Compositions according to the present invention avoid the inclusion of a polyhydric alcohol solvent in solubilizing amounts.Type: GrantFiled: February 22, 2001Date of Patent: October 9, 2001Inventor: Raj K. Chopra
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Patent number: 6294578Abstract: An insecticidal and miticidal composition is provided which comprises at least one fatty acid ester selected from the group consisting of glycerin monooleate, glycerin monolinolate, glycerin monocaprylate, glycerin mono/dioleate, glycerin di/trioleate, glycerin mono/dilinolate, glycerin mono/diricinoleate, glycerin diacetomonolaurate, sorbitan laurate, sorbitan oleate, diglycerin laurate, diglycerin oleate, diglycerin monolaurate, diglycerin monooleate, tetraglycerin oleate, hexaglycerin laurate, decaglycerin laurate, propylene glycol monolaurate, and propylene glycol monooleate; and a nonionic surfactant. The insecticidal and miticidal composition does not have phytotoxicity but has satisfactory long lasting effects even if it is used in a lower concentration.Type: GrantFiled: March 6, 1998Date of Patent: September 25, 2001Assignees: The Institute of Physical and Chemical ResearchInventors: Yutaka Arimoto, Isamu Yamaguchi
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Patent number: 6264939Abstract: Novel bisexual attractants for lepidopterous insect pests isolated from pears or apples. A method for monitoring and control of codling moth and other species of Lepidoptera comprising a lure and kill, mating disruption or mass trapping strategy. A method of using a formulation containing the bisexual attractants with or without an insecticide and/or pheromone for control of the insect pests.Type: GrantFiled: October 21, 1999Date of Patent: July 24, 2001Assignees: The United States of America, as represented by the Secretary of Agriculture, Trece, IncorporatedInventors: Douglas M. Light, Clive A. Henrick
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Patent number: 6255350Abstract: This invention relates to a single phase emulsifiable concentrate composition comprising (a) between about 0.05 and about 25 wt. % of a biologically, fungicidally and/or herbicidally active aza compound; (b) between about 2 and about 40 wt. % of a lactam selected from the group of N-methyl pyrrolidone, N-methyl caprolactam, a C8 to C18 alkyl pyrrolidone, a C8 to C18 caprolactam and a mixture thereof; (c) between about 2 and about 20 wt. % of a moisture scavenging agent selected from the group consisting of a liquid molecularly hindered carbodiimide, a molecular sieve or a mixture thereof and (d) between about 10 and about 80 wt. % of a mixture of at least two non-ionic surfactants having an overall hydrophilic/lipophilic balance (HLB) above 7. The invention also relates to the stable oil-in-water (o/w) miniemulsions prepared from the above by dilution to between about 40 and about 99.99 wt. % water for a “pour on”, dip or spray solution useful in the treatment of animals or plants.Type: GrantFiled: October 9, 1998Date of Patent: July 3, 2001Assignee: ISP Investments Inc.Inventors: Domingo I. Jon, Donald I. Prettypaul, Matthew J. Benning, Kolazi S. Narayanan, Robert M. Ianniello
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Patent number: 6201017Abstract: An ectoparasite-controlling agent for animals comprising 0.1 to 20% by weight of the neonocotinoid compounds defined in the specification and 10 to 95% by weight of a glycol or glycol monoalkyl ether has an excellent effectiveness by the application methods such as spot-on and pour-on application.Type: GrantFiled: September 21, 1999Date of Patent: March 13, 2001Assignee: Sumitomo Chemical Co., Ltd.Inventors: Satoshi Sembo, Mitsuyasu Makita
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Patent number: 6177476Abstract: A method of replenishing plasmalogens in mammals comprising treatment with a plasmalogen-replenishing-effective amount of one or more stantially pure monoethers of glycerols and their carboxylic acid ester derivatives of Formula I: wherein R is a C12-C22 linear or branched alkyl or alkenyl group; and R1 and R2 are, each independently, hydrogen or an acyl moiety {—C(═O)—R3} wherein R3 is a linear or branched C1-C30 alkyl or alkenyl; and pharmaceutically-acceptable salts thereof, is disclosed. Nutritional supplements, dietary supplements and food additives comprising one or more substantially pure compounds of Formula I is also disclosed.Type: GrantFiled: August 27, 1998Date of Patent: January 23, 2001Assignee: Clarion Pharmaceuticals Inc.Inventors: Andrew C. Peterson, Thaddeus P. Pruss
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Patent number: 6177469Abstract: The present invention concerns new immunosuppressive and antiviral pharmaceutical agents using lipid alcohols of the general formulae I and II in which R1 represents a straight-chained or branched, saturated or unsaturated alkyl chain with 1-30 carbon atoms which can optionally be substituted once or several times by halogen, C1-C6 alkoxy, C1-C6 alkylmercapto, C1-C6 alkoxycarbonyl, carboxy, C1-C6 alkylsulfinyl or C1-C6 alkylsulfonyl groups, R2 represents hydrogen, a straight-chained or branched, saturated or unsaturated alkyl chain with 1-20 carbon atoms which can optionally be substituted once or several times by halogen, C1-C6 alkoxy, C1-C6 alkylmercapto, C1-C6 alkoxycarbonyl or C1-C6 alkylsulfonyl groups, X represents a valency dash, oxicarbonyl, carbonyloxy, amidocarbonyl, carbonylamido, oxygen, sulphur, a sulfinyl or sulfonyl group Y represents a valency dash, oxicarbonyl, carbonyloxy, amidocarbonyl, carbonylamido, oxygen, sulphur, a sulfinyl or sulfonyl group n represents an integType: GrantFiled: June 22, 1998Date of Patent: January 23, 2001Inventors: Harald Zilch, Dieter Herrmann, Hans-Georg Opitz
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Patent number: 6177073Abstract: Compositions and methods are provided for attracting and subsequently trapping and/or killing adults of the Asian longhorned beetle, Anoplophora glabripennis, or interfering with their reproduction. The aggregation pheromones, 4-(n-heptyloxy)butanal and 4-(n-heptyloxy)butan-1-one, in combination with a trap or toxicant, provide means for monitoring, killing or inhibiting the reproduction of these insects.Type: GrantFiled: July 7, 1999Date of Patent: January 23, 2001Assignee: The United States of America as represented by the Secretary of the AgricultureInventors: Aijun Zhang, James E. Oliver, Jeffrey R. Aldrich
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Patent number: 6168808Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1) (R2) (R3)N→O (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.Type: GrantFiled: April 24, 1998Date of Patent: January 2, 2001Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques SeppicInventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
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Patent number: 6136866Abstract: Preparation for reducing the bond strength of adhesive tapes, consisting of at least one penetrant and at least one bond strength-reducing active substance which is skin-compatible and may make an active contribution to skincare, where the bond strength-reducing active substance contains at least one hydrocarbon chain of the form (C.sub.n H.sub.m) where n is the number of carbon atoms in the chain and has a value of greater than 6, and where the adhesive-reducing [sic] active substance has a primary irritation index of less than 3, with particular preference 0.Type: GrantFiled: February 10, 1998Date of Patent: October 24, 2000Assignee: Beiersdorf AGInventors: Peter Himmelsbach, Hanns Pietsch, Roland Knieler
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Patent number: 6060509Abstract: A pine root (Deutero mycetes) fungal metabolite and analogs thereof having antifungal activity.Type: GrantFiled: December 31, 1998Date of Patent: May 9, 2000Assignee: Millennium Pharmaceuticals, Inc.Inventor: Zhi-Dong Jiang
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Patent number: 6028117Abstract: Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.Type: GrantFiled: December 18, 1996Date of Patent: February 22, 2000Assignee: S. C. Johnson & Son, Inc.Inventor: John D. Hagarty
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Patent number: 5998483Abstract: Methods are provided to prepare a variety of tissues in a pathology-stable form keyed to the use of an aqueous solution of C.sub.2-6 dialdehyde and/or dialdehyde addition products, including the group consisting of glyoxal and/or glutaraldehyde in an amount sufficient to prevent autolysis and other degradative changes in various tissues. The said solution is capable of treating a tissue so as to maintain the tissue in a condition suitable for pathology and/or other experimental observation. The stabilizing solution is also useful to prepare parts or whole animals and plants in an anatomically preserved state for a prolonged period of time, and compositions useful in that method.Type: GrantFiled: December 6, 1996Date of Patent: December 7, 1999Inventor: Gerald W. Camiener