Ether Doai Patents (Class 514/715)
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Patent number: 5989559Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 29, 1998Date of Patent: November 23, 1999Assignee: Delft Pharma InternationalInventor: Bobby Gene Edwards
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Patent number: 5981604Abstract: The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.Type: GrantFiled: July 14, 1998Date of Patent: November 9, 1999Assignee: University of FloridaInventors: Charles M. Allen, Harry S. Nick
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Patent number: 5977187Abstract: Novel 4-substituted-1,2-naphthoquinones, pharmaceutical unit dosage forms containing 4-substituted-1,2-naphthoquinones, and uses of 4-substituted-1,2-naphthoquinones to inhibit the growth of cancer cells are disclosed.Type: GrantFiled: October 14, 1998Date of Patent: November 2, 1999Assignee: Wisconsin Alumni Research FoundationInventors: Benjamin J. Frydman, Donald T. Witiak, Laurence J. Marton, Karen Neder, M. Eileen Dolan
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Patent number: 5972344Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 14, 1999Date of Patent: October 26, 1999Inventor: Bobby Gene Edwards
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Patent number: 5972993Abstract: A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the treatment of rosacea and sensitive skin that are comprised of at least one antioxidant selected from the following groups of antioxidants: (a) phenolic compounds that contain at least one hydroxyl group connected directly to a benzene ring and to another unsaturated chemical grouping, (b) sulfur-containing compounds that contain at least one sulfhydryl groups or sulfur-containing compounds that contain at least one disulfide group, or (c) polyene compounds that have conjugated systems of double bonds.Type: GrantFiled: March 20, 1998Date of Patent: October 26, 1999Assignee: Avon Products, Inc.Inventor: Dmitri Ptchelintsev
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Patent number: 5962483Abstract: Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR.sup.1, where R.sup.1 is an optionally substituted alkyl group; X is --O--, --S-- or --N(R.sup.7)--, where R.sup.7 is a hydrogen atom or an alkyl group; R.sup.2 is an optionally substituted cycloalkyl or cycloalkenyl group; R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or an alkyl, --CO.sub.2 R.sup.8 (where R.sup.8 is a hydrogen atom or an alkyl, aryl, or aralkyl group), --CONR.sup.9 R.sup.10 (where R.sup.9 and R.sup.10 which may be the same or different is each a hydrogen atom or an alkyl, aryl or aralkyl group), --CSNR.sup.9 R.sup.10, --CN, --CH.sub.2 CN group; Z is --(CH.sub.2).sub.n -- (where n is zero or an integer 1, 2 or 3; R.sup.5 is an optionally substituted monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R.sup.Type: GrantFiled: January 16, 1998Date of Patent: October 5, 1999Assignee: Celltech Therapeutics, LimitedInventors: Graham John Warrellow, Valerie Anne Cole, Rikki Peter Alexander
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Patent number: 5955624Abstract: Alk-1-enyl glycerol derivatives and method of preparing same. The derivatives stimulate cell and tissue growth.Type: GrantFiled: June 7, 1995Date of Patent: September 21, 1999Assignee: Cell Therapeutics, Inc.Inventors: Edward Nudelman, Sen-Itiroh Hakomori
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Patent number: 5905074Abstract: A compound of the formula ##STR1## useful for treating vitamin D dependent disorders.Type: GrantFiled: December 18, 1997Date of Patent: May 18, 1999Assignee: Hoffmann-La Roche Inc.Inventor: Fernand Schneider
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Patent number: 5849711Abstract: Methods for inhibiting the secretion of .beta.-amyloid peptide (.beta.AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in .beta.AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for .beta.AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.Type: GrantFiled: June 6, 1995Date of Patent: December 15, 1998Assignee: Athena Neurosciences, Inc.Inventors: Jay S. Tung, Sukanto Sinha, Lisa McConlogue, Christopher M. F. Semko
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Patent number: 5827896Abstract: Pinitol and derivatives and metabolites thereof are useful in nutritional and medicinal compositions for lowering plasma free fatty acid levels and for treating conditions associated with insulin resistance, such as diabetes mellitus and its chronic complications; obesity; hyperlipidemias and dyslipidemias atherosclerosis; hypertension; cardiovascular disease; AIDS; cancer; wasting/cachexia; sepsis; trauma associated with burns, malnutrition, and stress; aging; lupus and other autoimmune diseases; endocrine disease; hyperuricemia, polycystic ovary syndrome and complications arising from athletic activity.Type: GrantFiled: March 4, 1996Date of Patent: October 27, 1998Assignee: Washington UniversityInventors: Richard E. Ostlund, William R. Sherman
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Patent number: 5827852Abstract: Pharmaceutical composition suitable for coating comprising a composition for oral administration in unit dosage form wherein said composition has been coated with from about 0.01% to about 10% by weight of the composition with a volatile aromatic compound selected from the group consisting of 3-1-menthoxy propane-1,2-diol, N-substituted-p-menthane-3-carboxamides and acyclic carboxamides and mixtures thereof.Type: GrantFiled: September 16, 1994Date of Patent: October 27, 1998Assignee: The Procter & Gamble CompanyInventors: Carmelita Macklin Russell, Allen I. Dines, James Grigg Upson
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Patent number: 5817879Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.Type: GrantFiled: August 26, 1996Date of Patent: October 6, 1998Assignee: Trustees of the University of PennsylvaniaInventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler
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Patent number: 5780516Abstract: The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.Type: GrantFiled: March 28, 1997Date of Patent: July 14, 1998Assignee: University of FloridaInventors: Charles M. Allen, Harry S. Nick
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Patent number: 5756857Abstract: A cyclohexanol derivative represented by the following general formula (1) and preferably the following general formula (1a): ##STR1## wherein R represents a linear or branched alkyl group having 1 to 5 carbon atoms. The above cyclohexanol derivative imparts satisfactory refrigeration to not only the mouth mucosa but also the skin. Moreover, it is practically odorless. A cool feeling and various cool feeling compositions which are practically odorless can be obtained from the cyclohexanol derivative.Type: GrantFiled: April 25, 1995Date of Patent: May 26, 1998Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Mitsuru Kuribayashi, Mitsuru Tanoue, Akira Nakagawa, Munehiko Hirano, Hideshi Oda
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Patent number: 5668172Abstract: A pharmaceutical compound of the formula ##STR1## in which R is hydrogen, halo or F.sub.2 HCO--; or a salt, amide or ester thereof, useful in the treatment of skeletal diseases.Type: GrantFiled: August 23, 1995Date of Patent: September 16, 1997Assignee: Lilly Industries LimitedInventors: Peter Thaddeus Gallagher, William Martin Owton, Andrew Caerwyn Williams
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Patent number: 5643951Abstract: Methods for the treatment of metabolic and/or cardiovascular disorders comprising administering to a human in need thereof a therapeutically effective amount of a composition comprising dichloroacetic acid or a pharmaceutically acceptable salt or derivative thereof and a pharmaceutically acceptable mixture of carbonate and bicarbonate ions, the weight ratio of dichloroacetic acid, derivative or salt thereof to the mixture of carbonate and bicarbonate ions being in the range of from about 100:1 to about 0.01:1.Type: GrantFiled: June 5, 1995Date of Patent: July 1, 1997Inventors: Peter W. Stacpoole, Robert M. Bersin
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Patent number: 5552434Abstract: Compounds of the formula ##STR1## where the dotted line represents a bond or the absence of a bond, the wavy lines represent bonds which are either in cis or trans configuration; R.sub.1 represents H, or CO--R.sub.2 where R.sub.2 is lower alkyl of 1 to 6 carbons, carbocyclic aryl or heterocyclic aryl; or carbocyclic aryl or heteroaryl substituted lower alkyl group; X represents CO--NR.sub.3 R.sub.4, CH.sub.2 OH, CH.sub.2 OR.sub.5, CH.sub.2 O--COR.sub.6, and CH.sub.2 --NR.sub.3 R.sub.4, where R.sub.3 and R.sub.4 independently are H or lower alkyl, R.sub.5 is lower alkyl of 1 to 6 carbons, and R.sub.6 is lower alkyl of 1 to 6 carbons, carbocyclic aryl or heterocyclic aryl; or carbocyclic aryl or heteroaryl substituted lower alkyl group, and n is an integer between 0 and 8 are capable of lowering intraocular pressure in the eye of a mammal.Type: GrantFiled: December 14, 1994Date of Patent: September 3, 1996Assignee: AllerganInventors: Michael E. Garst, Robert M. Burk
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Patent number: 5550166Abstract: Pinitol and derivatives and metabolites thereof are useful in nutritional and medicinal compositions for treating conditions associated with insulin resistance, such as diabetes mellitus and its chronic complications; obesity; hyperlipidemias and dyslipidemias atherosclerosis; hypertension; cardiovascular disease; AIDS; cancer; wasting/cachexia; sepsis; trauma associated with burns, malnutrition, and stress; aging; lupus and other autoimmune diseases; endocrine disease; hyperuricemia, polycystic ovary syndrome and complications arising from athletic activity or inactivity.Type: GrantFiled: March 17, 1995Date of Patent: August 27, 1996Inventors: Richard E. Ostlund, William R. Sherman
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Patent number: 5521221Abstract: This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma.Type: GrantFiled: April 9, 1991Date of Patent: May 28, 1996Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Jochen Buck, Ulrich Hammerling, Fadila Derguini, Koji Nakanishi
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Patent number: 5496536Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.Type: GrantFiled: April 25, 1995Date of Patent: March 5, 1996Inventor: Gerald Wolf
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Patent number: 5464866Abstract: Substituted hydrindanes and their use in controlling angiogenesis-dependent diseases in warm blooded animals are disclosed.Type: GrantFiled: March 10, 1994Date of Patent: November 7, 1995Assignee: Alcon Laboratories, Inc.Inventors: Abbot F. Clark, Raymond E. Conrow
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Patent number: 5462736Abstract: Disclosed is a clear, crystal-free, soap-gelled cosmetic stick composition. The composition includes a soap gelling agent (e.g., sodium stearate); at least two aliphatic polyhydric alcohols that are solvents for the soap gelling agent and that have a relatively small molecular weight and a relatively large molecular weight (e.g., propylene glycol and dipropylene glycol), respectively; a propoxylated ether that is a further solvent for the soap gelling agent, such as a propoxylated butyl ether (e.g., PPG-14 butyl ether); water; and a clarifying agent. The clarifying agent is a mixture of (a) a propoxylated fatty alcohol, such as a propoxylated myristyl ether (e.g., PPG-3 myristyl ether), and (b) a water-soluble, N-substituted aliphatic fatty acid amide surfactant (e.g., a combination of cocamide DEA and cocoyl sarcosine). The stick composition has improved surface aesthetics and improved payout, and has less pullaway from the container.Type: GrantFiled: June 2, 1993Date of Patent: October 31, 1995Assignee: The Mennen CompanyInventors: Dawn M. Rech, Morton L. Barr
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Patent number: 5447959Abstract: Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.Type: GrantFiled: March 5, 1993Date of Patent: September 5, 1995Assignee: MedaforInventor: Jacques Borg
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Patent number: 5441988Abstract: Described is a method of repelling insects by utilizing as active insect repellent ingredient 2,4-dimethyl-4-phenyl-1-butanol or .alpha.-terpinyl methyl ether (ORANGE FLOWER ETHER).Type: GrantFiled: August 12, 1994Date of Patent: August 15, 1995Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Jerry F. Butler, Anna B. Marin, Craig B. Warren, Richard A. Wilson, Braja D. Mookherjee
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Patent number: 5439511Abstract: A coating varnish composition comprising (A) a polymer obtained by polymerizing (a) at least one unsaturated acid anhydride and (b) at least one other unsaturated monomer, and (B) at least one additive selected from triazole derivatives, benzothiazole derivatives, thiadiazole derivatives, polyethers and carboxylic acid anhydride derivatives, is capable of forming a coating which has no danger of poisoning like the organotin copolymers, shows a coating consuming property and antifouling performance comparable with those of the organotin copolymers and does not gel even when mixed with a copper compound.Type: GrantFiled: January 12, 1994Date of Patent: August 8, 1995Assignee: Hitachi Chemical Company, Ltd.Inventors: Hiroyuki Tanaka, Seiji Tai, Koichi Kamijima
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Patent number: 5422365Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R'.sub.1 and R.sub.2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R.sub.2 groups being in the cis position in relation to the rings,and R, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R'a and R'b are as defined in the description,useful therapeutically in the regulation of the secretion of insulin.Type: GrantFiled: August 12, 1994Date of Patent: June 6, 1995Assignee: Adir et CompagnieInventors: David Billington, Francoise Perron-Sierra, Isabelle Picard, Jacques Duhault, Joseph Espinal
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Patent number: 5270345Abstract: Novel pesticidal compositions, which are characterized by biodegradability and do not bioaccumulate to an unacceptable level in fats and tissues of animals, fowl and fish, containing active compounds and optionally a carrier suitable for administering said compounds to a pest by contact, ingestion or inhalation, are disclosed. Such compositions comprise in addition to the carrier compounds of the formula ##STR1## where R is H, Cl or other Hal, hydroxyl, lower alkoxyl, lower alkyl, cyano, CONR.sub.2 or NR.sub.2 where R.sub.Type: GrantFiled: May 3, 1991Date of Patent: December 14, 1993Assignee: Coulston International CorporationInventor: Frederick Coulston
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Patent number: 5244670Abstract: Ingestible pharmaceutical compositions comprising pharmaceutical actives useful for treating upper gastrointestinal tract distress (e.g., antacid agents) and 3-1-menthoxy propane 1,2-diol in amounts effective for providing a cooling sensation to the throat.Type: GrantFiled: May 20, 1992Date of Patent: September 14, 1993Assignee: The Procter & Gamble CompanyInventors: James G. Upson, Carmelita M. Russell
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Patent number: 5236950Abstract: This invention relates to a hair-restorer comprising, as an active ingredient, (a) an acyclic branched higher aliphatic hydrocarbon of 20 carbon atoms which may be substituted with hydroxyl group or acyloxy group, or (b) an acyclic branched carboxylic acid of 20 carbon atoms or its derivative and to a process for hair growth.Type: GrantFiled: February 17, 1989Date of Patent: August 17, 1993Assignee: Toyama Chemical Co., Ltd.Inventors: Hajime Aoyama, Satoshi Ono, Osamu Oohashi, Hirokazu Narita, Shuntaro Takano
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Patent number: 5181276Abstract: The present invention relates to infection resistant materials and or products made from a molten blend of at least one polymer and a compound having antioxidant, plasticizer and antiviral activity. Additionally, this compound has a hydrophilic lipophilic balance of between 12 and 20. The preferred polymer, polyvinyl chloride, is blended with the antioxidant, plasticizer, antiviral compound NONOXYNOL-9 (.alpha.-nonylphenyl-w-hydroxypoly(oxy-1, 2-ethanediyl) to form the infection resistant material.Type: GrantFiled: September 9, 1991Date of Patent: January 26, 1993Assignee: Baxter International Inc.Inventors: Jean Kersten, Yves A. Delmotte
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Patent number: 5158775Abstract: A suspension type aerosol inhalations containing (a) 0.015 to 5.00% (w/w) of a pyrido[1,2-a]pyrimidine compound of the formula: ##STR1## where R is a n-propyl or allyl group, A is a tetrazolyl or carboxyl group, and n is a whole number of 0 to 2, and (b) 0.015 to 5.00% (w/w) of a fatty acid ester.Type: GrantFiled: June 14, 1990Date of Patent: October 27, 1992Assignee: Tokyo Tanabe Company, LimitedInventors: Takashi Yazaki, Yukio Goto
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Patent number: 5128123Abstract: A clear cosmetic stick is provided whose composition includes from about 10 to 90% of a polyhydric alcohol, from about 1 to about 40% of a soap, from about 1 to about 40% of an alkoxylate copolymer having the formula:[A--CH.sub.2 CH.sub.2 --A].sub.f [(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b (C.sub.2 H.sub.4 O).sub.c (C.sub.3 H.sub.6 O).sub.d ].sub.e [H].sub.gwhereinA is nitrogen;a, b, c and d are independently selected integers ranging from 0 to 200 with the proviso that the sum of a, b, c and d is at least about 50;e is an integer from 1 to 4;f is an integer from 0 to 1-;g is an integer from 0 to 4;and a clarifying agent which is a basic amine present in an effective amount to maintain stick clarity.Type: GrantFiled: February 8, 1991Date of Patent: July 7, 1992Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.Inventors: David A. Brewster, Matthew Kuznitz, Joseph R. Faryniarz
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Patent number: 5114703Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.Type: GrantFiled: May 29, 1990Date of Patent: May 19, 1992Assignee: Alliance Pharmaceutical Corp.Inventors: Gerald L. Wolf, David M. Long
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Patent number: 5102915Abstract: The present invention relates to a group of compounds which are novel squalene derivatives containing the cyclopropyloxy functionality and which act to inhibit the synthesis of cholesterol in mammals and in fungi.Type: GrantFiled: June 28, 1991Date of Patent: April 7, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael R. Angelastro, Norton P. Peet, Philippe Bey
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Patent number: 5093360Abstract: Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals in which retinal and its derivatives may be useful include age spots, wrinkles, warts, eczema, seborrheic keratoses, acne, oily skin, psoriasis, dandruff, xerosis, inflammatory and pruritic skin, disturbed keratinization skin changes associated with aging and possibly viral infections. Retinal and its derivatives include their stereoisomers, for example, all-trans, 13-cis, 11-cis, 9-cis, 7-cis, 11,13-cis and 9,13-cis vitamin A aldehydes, their hydrate, hemiacetal and acetal forms, and their adduct compounds. Compositions containing retinal or its derivative may be administered systemically such as orally, or topically to the affected areas of the skin.Type: GrantFiled: April 7, 1989Date of Patent: March 3, 1992Inventors: Ruey J. Yu, Eugene J. Van Scott
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Patent number: 5068113Abstract: The fibrous polymeric material based on polyvinyl chloride contains at least one antiseptic mercury derivative distributed in its polymeric structure in the form of a substantially molecular and practically non-releasable dispersion.The preferred mercury derivatives have the following general formula: ##STR1## in which Y is H or HgX. If the concentration of the derivative is equal to at least 0.5% by weight, relative to the chlorofiber, the latter has a permanent antiseptic character.This material is obtained by incorporating the above-mentioned derivative into the collodion when the chlorofiber is spun.Type: GrantFiled: September 20, 1989Date of Patent: November 26, 1991Assignees: Institut Textile de France, RhovylInventors: Michel Bourgeois, Roger Chatelin, Daniel Wattiez, Michel Sotton, Francois Belet, Georges Achard
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Patent number: 5053399Abstract: The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycle-dependent conditions. The present invention also provides novel myo-inositol analogs.Type: GrantFiled: October 12, 1990Date of Patent: October 1, 1991Assignee: University of PittsburghInventor: Alan P. Kozikowski
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Patent number: 5023247Abstract: A coating composition comprising a first phase containing a cross-linkable resin; a second phase containing water; and a third phase containing an insecticide dissolved in a solvent wherein the solvent is immiscible with the first phase and with water.These coating compositions kill insects even after exposure to weather for extended periods of time. They have kill rates higher than prior art compositions containing the same amount of the same insecticide.Type: GrantFiled: May 30, 1989Date of Patent: June 11, 1991Assignee: Insecta Paint, Inc.Inventors: Jean-Paul Boulanger, Jacques Lupuyo, Francois Klug
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Patent number: 5021448Abstract: A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist, or both in a combined uricosuric effective amount is disclosed. Compositions having one or more of the foregoing in combination with one or more known uricosurics are also set forth.Type: GrantFiled: February 22, 1990Date of Patent: June 4, 1991Assignee: Ciba-Geigy CorporationInventors: Anthony J. Piraino, Steven D. Saris
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Patent number: 4988682Abstract: The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycle-dependent conditions. The present invention also provides novel myo-inositol analogs.Type: GrantFiled: February 3, 1989Date of Patent: January 29, 1991Assignee: University of PittsburghInventor: Alan P. Kozikowski
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Patent number: 4983630Abstract: There are provided new 2,2-difluorocyclopropylethane derivatives of general formula I ##STR1## in which A, B and R.sup.1-5 have the meanings given in the description and processes for their preparation. The compounds of the invention can be used as pesticides, especially against insects and mites.Type: GrantFiled: November 28, 1988Date of Patent: January 8, 1991Assignee: Schering AktiengesellschaftInventors: Peter Wegner, Hartmut Joppien, Gunter Homberger, Arnim Kohn
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Patent number: 4965072Abstract: The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.Type: GrantFiled: November 3, 1988Date of Patent: October 23, 1990Assignee: Miles Inc.Inventors: Thomas A. Alexander, Lawrence J. Daher, Clarence L. Hancock, Donald L. Peterson
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Patent number: 4942179Abstract: A single-phase, either isotropic or anisotropic formulation is disclosed, which contains perfluorinated oil and one or more surfactant(s), is useful as an excipient for cosmetic and dermatologic formulations and is characterized in that at least one surfactant is selected from those having the following general formula: ##STR1## wherein: R.sub.F is an F--(CF.sub.2 --CF.sub.2).sub.i -- group;X is a group selected from: ##STR2## --(CH.sub.2 --O).sub.K --; and --(CH.sub.2 --S).sub.K --; wherein R.sup.I is a (C.sub.1 -C.sub.4)-alkyl;Y is a group selected from: NH.sub.2 (R.sup.II).sub.2 and N(R.sup.II).sub.4 ; wherein R.sup.II is a hydrogen atom, or a group selected from --CH.sub.2 --CH.sub.2 --OH and (C.sub.1 -C.sub.4)-alkyl;i is an integer comprised within the range of from 3 to 8;i is zero or 1;K is 2.l;l is an integer comprised within the range of from 1 to 10;m is 1 or 2.Such composition is spontaneously formed when the components are simply placed into contact with one another.Type: GrantFiled: June 14, 1988Date of Patent: July 17, 1990Assignees: Eniricherche S.p.A., Enichem Synthesis S.p.A.Inventors: Enrico Borgarello, Filippo M. Carlini, Carlo Neri, Edoardo Platone
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Patent number: 4904466Abstract: This invention relates to an aqueous gel comprising a specified capped polyether polymer and a surfactant. Preferred capped polyether polymers can be obtained by modifying a conventional polyether polyol with an alpha-olefin epoxide having an average of about 20 to 45 carbon atoms or mixtures thereof.Type: GrantFiled: December 27, 1988Date of Patent: February 27, 1990Assignee: BASF CorporationInventors: James E. Carson, James P. Owens
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Patent number: 4889689Abstract: A method of disinfecting a soft contact lens with a stabilized aqueous hydrogen peroxide solution having a pH between about 5.5 and about 7.5, a hydrogen peroxide content of between about 0.5 and about 6% by weight, and containing between about 0.003 and about 0.03% by weight of diethylene triamine penta(methylenephosphonic acid) or a physiologically compatable salt thereof, and compositions for use in such method.Type: GrantFiled: October 31, 1988Date of Patent: December 26, 1989Assignee: Ciba-Geigy CorporationInventor: Fupao Tsao
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Patent number: 4853413Abstract: Described are animal control compositions and methods; which compositions comprise citronellyl nitrile, citronellol and, optionally, methyl terpenyl ether, lemon oil, caryophyllene, isopulegol, isopulegyl acetate and quinine or one or more of its salts. The compositions can be used "as is" or in the form of a "controlled release" composition whereby the citronellyl nitrile, citronellol and, optionally, methyl terpenyl ether, lemon oil, caryophyllene, isopulegol, isopulegyl acetate and quinine or one or more of its salts are intimately admixed (alone or with adjuvants including but not limited to other volatile, odorous ingredients) with a polymeric substance such as polyethylene in the form of pellets or functional articles, e.g., garbage bags.Type: GrantFiled: April 3, 1987Date of Patent: August 1, 1989Assignee: International Flavors & Fragrances Inc.Inventors: Ira Katz, Donald A. Withycombe
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Patent number: 4847292Abstract: Described are animal control compositions and methods; which compositions comprise citronellyl nitrile, citronellol alpha-terpinyl methyl ether and lemon oil and, optionally, caryophyllene, isopulegol, isopulegyl acetate, one or more norbornyl alkyl ethers, one or more 3,4,5,6,6-pentamethyl hexanol-2 derivatives and quinine or one or more of its salts. The compositions can be used "as is" or in the form of a "controlled release" composition whereby the citronellyl nitrile, citronellol, alpha-terpinyl methyl ether and lemon oil and, optionally, the caryophyllene, isopulegol, isopulegyl acetate, one or more norbornyl alkyl ethers, one or more 3,4,5,6,6-pentamethyl hexanol-2 derivatives and quinine or one or more of its salts are intimately admixed (alone or with adjuvants including but not limited to other volatile, odorous ingredients) with a polymeric substance such as polyethylene in the form of pellets or functional articles, e.g., garbage bags.Type: GrantFiled: June 29, 1987Date of Patent: July 11, 1989Assignee: International Flavors & Fragrances Inc.Inventors: Ira Katz, Donald A. Withycombe, deceased, Marie R. Hanna
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Patent number: 4810503Abstract: This invention relates to an aqueous gel comprising a specified capped polyether polymer and a surfactant. Preferred capped polyether polymers can be obtained by modifying a conventional polyether polyol with an alpha-olefin epoxide having an average of about 20 to 45 carbon atoms or mixtures thereof.Type: GrantFiled: March 31, 1987Date of Patent: March 7, 1989Assignee: BASF CorporationInventors: James E. Carson, James P. Owens
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Patent number: 4794000Abstract: The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic, amphoteric, and non-toxic surfactants, polysaccharides, synthetic polymers and polysorbates and their derivatives, and in which a pharmaceutical component is incorporated. The delivery system may be prepared in the form of a microemulsion as well as other forms including encapuslated microparticles. The claimed oral composition is useful to delivery oral dosage forms of drugs, their salts and derivatives thereof; biologicals, enzymes, and other pharmocologically active compositions. A method to prepare the oral drug delivery system is also disclosed.Type: GrantFiled: January 8, 1987Date of Patent: December 27, 1988Assignee: Synthetic Blood CorporationInventor: Bernard Ecanow
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Patent number: 4735803Abstract: Described are animal control compositions and methods; which compositions comprise lemon oil and .alpha.-terpinyl methyl ether taken alone or taken further together with quinine or salts thereof. The compositions can be used "as is" or in the form of a "controlled release" composition whereby the lemon oil and .alpha.-terpinyl methyl ether taken alone or further together with quinine or a salt thereof are intimately admixed (alone or with adjuvants including but not limited to other volatile, odorous ingredients) with a polymeric substance such as polyethylene in the form of pellets or functional articles, e.g., garbage bags.Type: GrantFiled: February 14, 1986Date of Patent: April 5, 1988Assignee: International Flavors & Fragrances Inc.Inventors: Ira Katz, Donald A. Withycombe