C-o-group (e.g., Alcohol, Alcoholate, Etc.) Doai Patents (Class 514/724)
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Bioactive polymeric liquid formulations of absorbable, segmented aliphatic polyurethane compositions
Patent number: 8952075Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.Type: GrantFiled: May 22, 2009Date of Patent: February 10, 2015Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby -
Publication number: 20150038441Abstract: The invention relates to a kit-in-part comprising of a composition for the use as a cleaning and treating of ears of a companion animal and suitable packaging material, wherein the kit-in part additionally consists of components selected from the group of a pharmaceutical composition for use in the treatment of otitis externa, application and dosage information, cannules, cotton swabs, gauzes and information about the cleaning and maintenance ears of a companion animal.Type: ApplicationFiled: December 21, 2011Publication date: February 5, 2015Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Joachim Karle, Reinhard Seffner
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Patent number: 8945595Abstract: The disclosure provides compounds useful as insect repellents and compositions comprising such repellents. The disclosure further provides insect traps.Type: GrantFiled: March 4, 2009Date of Patent: February 3, 2015Assignee: The Regents of the University of CaliforniaInventors: Anandasankar Ray, Stephanie Lynn Turner
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Patent number: 8940797Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.Type: GrantFiled: November 20, 2013Date of Patent: January 27, 2015Assignee: Ecolab USA Inc.Inventors: Joseph R. Wegner, Cheryl A. Littau
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Publication number: 20150025156Abstract: Antimicrobial and foamable alcoholic compositions, where the compositions include at least about 40 wt. % of a C1-4 alcohol and one or more silane surfactants selected from (1) zwitterionic silane surfactants, (2) polyalkoxylated silane surfactants that contain at least one silane group and at least one polyalkylene oxide chain.Type: ApplicationFiled: February 22, 2013Publication date: January 22, 2015Inventors: Evan D. Hillman, Daniel J. Lacks, Mitchell J. Cohen
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Publication number: 20150011651Abstract: The present invention provides beverages and pharmaceutical compositions containing a deuterated alcohol according to Formula 1, and provides methods for their manufacture and use. The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing.Type: ApplicationFiled: January 13, 2014Publication date: January 8, 2015Applicant: PROTIA, LLCInventors: Anthony W. Czarnik, Jeffrey A. McKinney
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Publication number: 20150011652Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.Type: ApplicationFiled: September 25, 2014Publication date: January 8, 2015Inventors: Joseph R. Wegner, Cheryl A. Littau
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Publication number: 20140369758Abstract: The instant invention relates to methods for increasing or promoting microbial activity in soil selected for treatment.Type: ApplicationFiled: September 3, 2014Publication date: December 18, 2014Applicant: ORO AGRI, INC.Inventors: Erroll Melvyn Pullen, Melvin Donovan Pullen
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Publication number: 20140364509Abstract: Applicants have identified a critical skin benefit package that can be used in liquid alcohol sanitizing compositions that provides lower amounts of skin conditioners in combination with a specific ratio of different emollients that provide improved skin health with chronic repeated use. The package also provides improved skin feel with without a tacky residue upon drying.Type: ApplicationFiled: June 6, 2013Publication date: December 11, 2014Inventors: Joseph R. Wegner, Cheryl A. Littau
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Publication number: 20140357727Abstract: The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides fatty acyl-CoA reductase (FAR) variant enzymes, polynucleotides encoding the FAR variant enzymes, and vectors and host cells comprising polynucleotides encoding the FAR variant enzymes.Type: ApplicationFiled: December 13, 2012Publication date: December 4, 2014Inventors: Louis A. Clark, Kristian Karlshoej, Patricia Choudhary
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Patent number: 8901172Abstract: A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition comprising or consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as Herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.Type: GrantFiled: June 11, 2012Date of Patent: December 2, 2014Assignee: Topical Rememdy, LLCInventors: Thomas Konowalchuk, Jack Konowalchuk
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Publication number: 20140348944Abstract: This invention relates to a “high lower alcohol content”(>40% v/v of a C1-4 alcohol) liquid composition able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a silicone-based surfactant of at least 0.001% by weight to prepare a foamable composition, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and moisturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.Type: ApplicationFiled: February 24, 2014Publication date: November 27, 2014Applicant: Deb Worldwide Healthcare Inc.Inventors: Maria Teresa Fernandez de Castro, Bruce Michael Koivisto, Francisco Munoz
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Patent number: 8877818Abstract: Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.Type: GrantFiled: May 21, 2007Date of Patent: November 4, 2014Assignees: XY, LLC, CHD Bioscience, IncInventors: Edwin Dean Neas, Jerald Edward Kuiken, John Louis Schenk, Thomas Boyd Gilligan
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Patent number: 8865232Abstract: The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.Type: GrantFiled: April 4, 2013Date of Patent: October 21, 2014Assignee: TissueTech, Inc.Inventors: Ying-Ying Gao, Scheffer Tseng
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Patent number: 8859619Abstract: Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.Type: GrantFiled: November 26, 2012Date of Patent: October 14, 2014Assignee: Jazz Pharmaceuticals, Inc.Inventors: Harry Cook, Martha Hamilton, Douglas Danielson, Colette Goderstad, Dayton T. Reardan
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Patent number: 8859627Abstract: The present invention relates to an anti-microbial composition and method of use thereof. In particular, the present invention relates to an anti microbial composition comprising farnesol and cetrimide.Type: GrantFiled: October 23, 2008Date of Patent: October 14, 2014Assignee: Wild ChildInventor: John Found
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Patent number: 8859629Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: April 26, 2011Date of Patent: October 14, 2014Assignee: Synaffix B.V.Inventors: Floris Louis van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Publication number: 20140296350Abstract: A hand sanitizer composition that provides effective skin sanitization and exhibits low flammability, while containing sufficient humectant for moisturization of the skin includes an alcohol selected from the group consisting of alcohol(s) containing 4 to 6 carbon atoms in an amount of from about 10% to about 60% by volume, and one or more humectants present in an amount of from about 10% to about 80% by volume.Type: ApplicationFiled: October 24, 2012Publication date: October 2, 2014Applicant: Working Bugs, LLCInventors: Cordell DeMattei, Dianne Holman, Peter K. Rossman, Thomas A. Auchtung
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Publication number: 20140296348Abstract: The present invention provides an aqueous ophthalmic composition having a pH of 7 or more, containing a terpenoid and zinc chloride. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.Type: ApplicationFiled: October 31, 2012Publication date: October 2, 2014Inventors: Yasuko Matsumura, Chinatsu Furumiya, Masashi Itoh
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Patent number: 8846072Abstract: The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.Type: GrantFiled: March 7, 2013Date of Patent: September 30, 2014Assignee: Durect CorporationInventor: A. Neil Verity
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Patent number: 8840911Abstract: The present disclosure generally relates to moisturizing hand sanitizers including alcohols that are effective in killing microorganisms while providing a moisturizing benefit to the user's skin. More particularly, the alcohol-based hand sanitizers include a high internal phase emulsion which allows moisturizers or skin protectants such as emollients and/or silicones to be stably incorporated into the sanitizer.Type: GrantFiled: March 7, 2008Date of Patent: September 23, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Lisa Ann Flugge-Berendes, Scott W. Wenzel, Corey Thomas Cunningham
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Publication number: 20140275285Abstract: The present invention provides methods of regulating physiological and metabolic parameters and of treating diseases by administering metadichol to a subject in need of such regulation and/or treatment. Metadichol can be administered as a liquid or gel formulation.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Applicant: NanoRx, Inc.Inventor: Palayakotai R. Raghavan
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Publication number: 20140274683Abstract: Compositions including (a) a pollinating insect repelling, controlling, or directing compound or composition and (b) a compound or composition capable of protecting seeds, plant parts, or plants against insect and/or nematode infestation are provided. The disclosure also provides for methods of repelling, controlling, or directing a pollinating insect, for example a bee, while protecting seeds, plant parts, and/or plants against insect and/or nematode infestation. Seeds, plants, and plant parts treated with compositions described herein are also provided for by the disclosure.Type: ApplicationFiled: March 5, 2014Publication date: September 18, 2014Applicant: Bayer CropScience LPInventors: Tai-Teh WU, Dick ROGERS, Jian ZHANG, Robert CROFT, Chi Yu Roy CHEN
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Publication number: 20140272106Abstract: A method is provided for measuring the interaction of a disinfecting composition with a floor wax. The method include coating a surface with floor wax, allowing the coating to dry, applying a selected amount of disinfecting composition to the coated surface, and measuring, after a pre-determined amount of time, the tack of the surface, by using a controlled force measurement inverted probe machine. A detectable amount of tack indicates that the disinfecting composition has interacted with the floor wax. Alternatively, any tacky residue on the dried product surface may be sampled and analyzed by Fourier transform spectroscopy. Absorption at a wavelength associated with the floor wax indicates that the product has interacted with the floor wax. A foamable disinfecting composition having reduced interaction with floor wax is also provided.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: GOJO INDUSTRIES, INC.Inventors: Amanda Jo Copeland, Jeffrey Ross Davidson
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Publication number: 20140271717Abstract: Effective devices and methods using a chemical denervation agent are provided for treating chronic back pain. The devices and methods comprise a chemical denervation agent to degrade or to shrink at least a portion of a nerve associated with back pain e.g. basivertebral nerve of the lumbar. In some embodiments, the methods and devices are configured to immediately release an effective amount of the chemical denervation agent within 24 hours and provide sustained release of the chemical denervation agent or other therapeutic agent over a period of up to one year to treat chronic back pain.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: KYPHON SARLInventors: MOJAN GOSHAYESHGAR, Michael A. Smith
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Patent number: 8835014Abstract: The invention described herein relates to a therapeutic, moisturizing coating composition for elastomeric articles which is applied directly onto the skin-contacting surface of the article as part of the manufacturing process. The coating composition is thermally stable and subsequently hydrates when contacted with a moisturized skin surface to convert into a liquid “lotion” form during wearing of the article. The coating composition provides therapeutic benefits to the wearer's skin as a result of wearing the article, such as improved skin moisturization, softness of feel, improved skin elasticity and firmness, and reduced redness and irritation. The invention is particularly useful in medical gloves, including examination and surgical gloves.Type: GrantFiled: October 21, 2003Date of Patent: September 16, 2014Assignee: Allegiance CorporationInventors: Shiping Wang, Yun-Siung Tony Yeh, James Owens, Wei Cheong Wong
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Patent number: 8829053Abstract: An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.Type: GrantFiled: December 7, 2011Date of Patent: September 9, 2014Assignee: Rochal Industries LLPInventors: Joseph Salamone, Ann Beal Salamone
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Patent number: 8822547Abstract: A hydroalcoholic gel composition includes greater than about 40 weight percent of an alcohol, based upon the total weight of the alcoholic composition, a polyacrylate thickener, and an ester plug-preventing agent. The composition is suitable for use in dispensers, and exhibits reduced mis-directed output when the dispenser is actuated.Type: GrantFiled: October 29, 2008Date of Patent: September 2, 2014Assignee: GOJO Industries, Inc.Inventors: Marcia Snyder, Carol A. Quezada
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Patent number: 8822546Abstract: Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.Type: GrantFiled: December 1, 2008Date of Patent: September 2, 2014Assignee: Medtronic, Inc.Inventors: Michael Eric Benz, Christopher M. Hobot, Phillip Edward McDonald, Lian Leon Luo, John Kramer
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Publication number: 20140243725Abstract: An antimicrobial medical dressing provides a combination of antimicrobial agents in various concentrations that protect against microorganisms, absorb exudates, and promote healing. The antimicrobial agents may include compositions of ethanol, hydrogen peroxide, and/or ethylenediaminetetraacetic acid.Type: ApplicationFiled: May 6, 2014Publication date: August 28, 2014Applicant: Hyprotek, Inc.Inventors: Patrick O. Tennican, L. Myles Phipps
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Publication number: 20140234225Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.Type: ApplicationFiled: February 17, 2014Publication date: August 21, 2014Applicant: Alkermes Pharma Ireland LimitedInventors: Christian F. Wertz, Niels P. Ryde
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Publication number: 20140228448Abstract: The present invention relates to the use of R—OH alcohols as phagodeterrents, and to a method for treating plants infested with aphids which comprises the administration of these R—OH alcohols.Type: ApplicationFiled: May 14, 2012Publication date: August 14, 2014Applicant: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Maria Agnese Sabatini, Sonia Ganassi, Claudio Altomare, Mara Favilla, Antonio Evidente, Anna Andolfi
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Patent number: 8802061Abstract: The present invention is drawn to disinfectant or sterilant compositions, which are human safe, e.g., food grade, food safe, or skin safe, etc. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal or alloy thereof based on the aqueous vehicle content can also be present. The disinfectant composition can be used in the manufacture and formulation of products for human use or consumption including disinfectant mouthwashes, toothpastes, gums, ointments, and soaps.Type: GrantFiled: February 24, 2006Date of Patent: August 12, 2014Assignee: Solutions BioMed, LLCInventors: Daryl J. Tichy, Brian G. Larson
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Patent number: 8802729Abstract: Biodegradable detergent compositions comprising enzymes and 1,3-propanediol are provided. The 1,3-propanediol in the composition is biologically derived and enhances the stability of the enzymes in the composition. The compositions also exhibit a low anthropogenic CO2 emission profile.Type: GrantFiled: March 15, 2013Date of Patent: August 12, 2014Assignee: DuPont Tate & Lyle Bio Products Company, LLCInventors: Gyorgyi Fenyvesi, Melissa Joerger, Robert Miller, Raja Hari Poladi, Ann Wehner
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Patent number: 8802737Abstract: A method for improving tetracycline-resistance of A. baumannii, by providing a ginger compound combined with tetracycline to against A. baumannii infection, wherein the ginger compound comprises [6]-dehydrogingerdione, [6]-shogaol and [6]-gingerol or [10]-gingerol, [6]-shogaol and [6]-gingerol.Type: GrantFiled: September 17, 2013Date of Patent: August 12, 2014Assignee: Kaohsiung Medical UniversityInventors: Yen-Hsu Chen, Hui-Min Wang, Chung-Yi Chen, Hsi-An Chen, Wei-Ru Lin
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Publication number: 20140221502Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: DEB IP LimitedInventors: Marcel Veeger, Markus Himming
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Patent number: 8784862Abstract: The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.Type: GrantFiled: June 30, 2010Date of Patent: July 22, 2014Assignee: Hemoteq AGInventors: Roland Horres, Marita Katharina Linssen, Michael Hoffmann, Erika Hoffmann, Donate DiBiase, Volker Faust
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Patent number: 8784892Abstract: The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns.Type: GrantFiled: July 7, 2010Date of Patent: July 22, 2014Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Elka Touitou
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Patent number: 8772354Abstract: The present invention relates to the field of perfumery and more particularly to the field of malodor counteractancy. In particular, it relates to a method for application of malodor counteracting (MOC) compositions capable of neutralizing in an efficient manner, through chemical reactions, malodors of a large variety of origins and which can be encountered in the air, on textiles, bathroom or kitchen surfaces, and the like. The composition may be applied as is or in the form of a perfuming composition or in a consumer product or article containing the compound or perfume composition.Type: GrantFiled: January 19, 2012Date of Patent: July 8, 2014Assignee: Firmenich SAInventors: Jonathan Williams, Lyse Tranzeat
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Patent number: 8759404Abstract: The invention discloses a stable intravenous Propofol oil-in-water emulsion composition having mixed preservatives of low toxicity that is capable of withstanding accidental contamination of bacteria and fungi. The preservative system employed comprising of monoglyceryl ester of lauric acid (Monolaurin) and a member selected from (a) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (Monocaprin); (b) edetate; and (c) capric acid and/or its soluble alkaline salts or its monoglyceryl ester (Monocaprin) and edetate.Type: GrantFiled: March 2, 2007Date of Patent: June 24, 2014Assignee: Bharat Serums & Vaccines Ltd.Inventors: Gautam Vinod Daftary, Srikanth Annappa Pai, Girish Narasimha Shanbhag, Sangeeta Hanurmesh Rivankar
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Patent number: 8758737Abstract: A liquid evaporative cooling composition has been discovered which is peculiarly effective in providing relief from heat-related discomfort. The composition utilizes a concentrate, dissolved in water, which preferably consists essentially of (a) about forty-three percent by weight of an alcohol; (b) about twelve percent by weight of a surfactant; (c) about four percent by weight of an aromatic oil; (d) about one percent by weight of a cooling agent; and (e) about forty percent by weight of water. Various ranges of concentrations for the composition components have been discovered, the concentration ranges featuring various advantages and disadvantages, and these ranges are disclosed herein. The composition can be applied to the surface to be cooled (typically, a user's skin) in a number of ways and has even been found to relieve heat-related discomfort in animals.Type: GrantFiled: November 14, 2012Date of Patent: June 24, 2014Inventors: Carl Patrick Tate, Kerri Lynn Tate, Albert Scott Adamson
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Patent number: 8753665Abstract: The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. Preferably the composition contains bupivacaine and a sugar ester such as saib.Type: GrantFiled: September 15, 2005Date of Patent: June 17, 2014Assignee: Durect CorporationInventor: A. Neil Verity
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Patent number: 8722093Abstract: The present invention provides nanoparticulate policosanol, formulations including these particles, as a well as methods of using the particles and formulations for treatment and prophylaxis of various diseases and conditions.Type: GrantFiled: January 21, 2010Date of Patent: May 13, 2014Assignee: NanoRx, Inc.Inventor: Palayakotai R. Raghavan
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Patent number: 8716355Abstract: Compounds of the hydroxytolan family kill tumor cells, inhibit tumor growth and development, and are thus useful in method for treating a tumor or cancer in subjects in need thereof. These compounds are also active in preventing or treating a variety of skin diseases and conditions. The most preferred hydroxytolan compounds are 4,4?-dihydroxytolan. (KST-201), 4 hydroxy 4? trifluoromethyltolan or 4? hydroxy 4 trifluoromethyltolan (KST-213), 3,4?,5-trihydroxytolan or 3?,4,5?-trihydroxytolan (KST-301) and 3,3?,5,5?-tetrahydroxytolan (KST-401). The compounds and methods of using them alone and in combination with ascorbate and certain cyclic compounds to inhibit the development, growth or metastasis of tumor/cancer or preneoplastic cells, or to prevent or treat skin disorders in a subject are disclosed.Type: GrantFiled: June 20, 2008Date of Patent: May 6, 2014Assignee: Kent State UniversityInventor: Chun-che Tsai
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Patent number: 8703828Abstract: In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one paraben, a redox compound and an organic acid at a concentration of from about 1.5 percent to about 10 percent by weight, based on the total weight of the composition. In other aspects, antimicrobial compositions are used to topically sanitize wounds, skin areas and/or to disinfect surgical instruments or other surfaces. Still, in further aspects, methods, devices and kits relating to an antimicrobial composition are provided.Type: GrantFiled: March 4, 2013Date of Patent: April 22, 2014Assignee: Zurex Pharma, Inc.Inventors: Stephen R. Ash, Janusz Steczko
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Patent number: 8703748Abstract: The present invention relates to a cleaning composition for removing cellular components from tissue for transplantation derived from humans and animals. More particularly, the present invention relates to a cleaning composition for treating tissue for transplantation comprising a polyoxyethyleneglycol C14-C20alkyl ether as a first protein solubilizing component, a C6-C8alkylphenol polyethoxylate as a first lipid solubilizing component, a C10-C16alkyl glycoside as a second protein solubilizing component and a C9-C12alkylphenoxy polyethoxy ethanol as a second lipid solubilizing component.Type: GrantFiled: February 10, 2010Date of Patent: April 22, 2014Assignee: CG BIO Co., Ltd.Inventors: Byoung Suck Kim, Seok Beom Song, Goo Won Jeong, Hyo Jung Kang, Jae Deuck Jung
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Patent number: 8703829Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: GrantFiled: May 23, 2012Date of Patent: April 22, 2014Assignee: University of Louisville Research Foundation, Inc.Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Patent number: 8697747Abstract: Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).Type: GrantFiled: March 5, 2010Date of Patent: April 15, 2014Assignee: THe UAB Research FoundationInventors: Vance G. Nielsen, James F. George, James K. Kirklin
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Patent number: 8697103Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.Type: GrantFiled: February 6, 2012Date of Patent: April 15, 2014Assignee: Deb IP LimitedInventors: Marcel Veeger, Markus Himming
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Publication number: 20140100278Abstract: The present invention relates to compounds according to formula (I) for medical use. The compounds are particularly suitable for the treatment and/or prevention of a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue. Furthermore, the invention relates to the use of said compounds for preparing a medicament and to pharmaceutical preparations comprising such compounds. The invention also relates to methods of treating or protecting patients having or being prone to develop a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue, the methods comprising administration of a therapeutically effective amount of such compounds.Type: ApplicationFiled: December 11, 2013Publication date: April 10, 2014Applicants: ETH ZURICH, UNIVERSITY OF ZURICHInventors: Ludwig K. Limbach, Inge K. Herrmann, Beatrice Beck-Schimmer, Wendelin J. Stark, Martin Urner