Polyhydroxy Patents (Class 514/738)
  • Patent number: 8263142
    Abstract: The invention provides olive-derived hydroxytyrosol. According to one aspect of the invention, vegetation water is collected from olives. Acid is added to stabilize the vegetation water and prevent fermentation. The mixture is incubated to allow oleoeuropein to convert to hydroxytyrosol, and then fractionated to separate hydroxytyrosol from other components. The hydroxytyrosol is useful as a natural anti-bacterial, anti-viral and fungicidal product for agricultural and pest control applications. In addition, it is useful as a therapeutic and anti-oxidant for a variety of health purposes.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: September 11, 2012
    Assignee: CreAgri, Inc.
    Inventor: Roberto Crea
  • Publication number: 20120225908
    Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 6, 2012
    Applicant: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20120225840
    Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
    Type: Application
    Filed: October 15, 2009
    Publication date: September 6, 2012
    Inventors: Ann Fowler, Angelika Friedel, Darko Knutti, Karin Kuratli, Daniel Raederstorff, Ying Wang-Schmidt, Karin Wertz
  • Publication number: 20120225109
    Abstract: A formulation to reduce the numbers of bacteria, particularly Gram positive bacteria, in a space such as a waste disposal bin, via the vapor phase, and active over a long period, typically several weeks. The product comprises one or more essential oils or essential oil components plus a mixture of volatile and non-volatile solvents, on a carrier such as a non-woven, sintered plastic or cardboard.
    Type: Application
    Filed: March 9, 2012
    Publication date: September 6, 2012
    Inventors: Philip Caunt, Deborah Williams
  • Patent number: 8231884
    Abstract: The invention concerns particles consisting essentially of fibers of an organogelling substance in the form of xerogel (dry gel), the fibers being essentially oriented in a common direction and randomly aligned around the longest fiber. The organogelling substance is preferably 1,3: 2,4-di-O-benzylidene-D-sorbitol. Said particles, which are in the form of spindles, have interesting optical properties; they have a total light transmittance higher than 0.80, with a diffuse transmittance higher than the specular transmittance. The invention also concerns a method for preparing said particles by solvent evaporation process, by solvent diffusion/evaporation process or by shearing process. The invention finally concerns active particles consisting of said particles whereon is immobilized a dermocosmetically active principle, a dermocosmetic composition comprising said particles or said active particles and a cosmetic treatment method which consists in applying on the skin said dermocosmetic composition.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: July 31, 2012
    Assignees: Pierre Fabre Dermo-Cosmetique, Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Anne Doat, Emile Perez, Isabelle Rico-Lattes, Pascal Bordat
  • Publication number: 20120148508
    Abstract: The invention relates to a coloured fragrancing composition comprising, in a cosmetically acceptable medium: a) at least 2% by weight of a fragrancing substance relative to the total weight of the composition; b) at least one derivative of: benzylidene camphor containing a sulphonic function or a benzotriazole silicone of particular formula (1) that will be defined below in detail; c) at least one dye that is soluble in said medium; said composition not containing an alkyl ?,??-diphenylacrylate compound or an alkyl ?-cyano-?,??-diphenylacrylate compound. The invention also relates to a cosmetic method for fragrancing human keratin substances and in particular the skin, lips and integuments, comprising the application to the keratin substances of the composition defined previously.
    Type: Application
    Filed: November 18, 2010
    Publication date: June 14, 2012
    Applicant: L'OREAL
    Inventors: Willy Thfoin, Boris Grimal
  • Publication number: 20120148510
    Abstract: A method of improving the appearance of facial pores is provided. The method includes the step of applying a composition having an effective amount of a material that regulates IL-1 and/or hyaluronic acid synthesis to an area of facial pores, wherein the composition is applied for a period of time sufficient for the material to improve the appearance of the facial pores. In some embodiments, the material that regulates IL-1 and/or hyaluronic acid synthesis is hexyldecanol. The method may also include the step of identifying facial pores on a facial skin surface.
    Type: Application
    Filed: November 17, 2011
    Publication date: June 14, 2012
    Inventors: Tomohiro HAKOZAKI, Leo Timothy Laughlin, II
  • Patent number: 8188127
    Abstract: Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: May 29, 2012
    Assignee: Rohm and Haas Company
    Inventors: Richard Levy, Beverly Jean El A'mma, Beat Heer, Kiran Pareek
  • Publication number: 20120129950
    Abstract: A method for rapid surface sanitization is provided, where the method includes contacting the surface with an effective amount of an antimicrobial composition comprising at least about 50 wt. % of a C1-6 alcohol, based upon the total weight of the antimicrobial composition; and an efficacy-enhancing amount of a C1-10 alkane diol.
    Type: Application
    Filed: June 14, 2010
    Publication date: May 24, 2012
    Inventors: David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
  • Patent number: 8182794
    Abstract: Sunless tanning compositions are substantially improved by adding methylsulfonyl methane [MSM] and certain glycols to Dihydroxyacetone (DHA).
    Type: Grant
    Filed: April 1, 2006
    Date of Patent: May 22, 2012
    Inventors: John Patrick McCook, Philip J. Gordon, D. Craig Woodward
  • Patent number: 8182793
    Abstract: Aqueous sunless tanning formulations employed for automatic spray systems with enhanced tanning and skin moisturization properties.
    Type: Grant
    Filed: December 18, 2004
    Date of Patent: May 22, 2012
    Inventors: John Patrick McCook, Philip J. Gordon, D. Craig Woodward
  • Patent number: 8183290
    Abstract: The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs. In particular a 2:1 complex of naproxen sodium to propylene glycol is disclosed which is a crystalline solid. The complex is prepared by crystallization of a mixture of naproxen sodium and propylene glycol from diethyl ether. It is identifiable by its X-ray powder diffraction pattern described herein.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: May 22, 2012
    Assignee: McNeil-PPC, Inc.
    Inventors: Mark Tawa, Örn Almarsson, Julius Remenar
  • Patent number: 8178584
    Abstract: The present invention relates to a water-in-oil emulsified composition containing a sphingosine represented by the following formula (1): (R1 represents a hydrocarbon group optionally having a substituent; Y represents methylene, methine or O; X1, X2 and X3 each represent H, OH or acetoxy group; X4 represents H, acetyl group or the like; R2, R3 each represents H, OH or the like; R represents H, amidino group or the like; and a stands for 2 or 3), (B) a C6-30 fatty acid, and (C) an oil component. This water-in-oil emulsified composition has excellent stability and provides a good feeling to skin upon use.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: May 15, 2012
    Assignee: Kao Corporation
    Inventors: Koji Okubo, Yumiko Yamamoto
  • Publication number: 20120114728
    Abstract: A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms.
    Type: Application
    Filed: February 12, 2010
    Publication date: May 10, 2012
    Inventors: Wilson Kurt Whitekettle, Gloria Jean Tafel, Kimberly Murphy, Qing Zhao
  • Publication number: 20120108674
    Abstract: An injectable hydrogel, includes, in weight, in a physiologically acceptable carrier fluid: 0.01 to 5% of glycerol and 0.1 to 5% of cross-linked hyaluronic acid, or one of the salts thereof; characterized in that the hyaluronic acid or one of the salts thereof is cross-linked by the formation of covalent bonds using bifunctional or polyfunctional molecules, the injectable hydrogel being sterilized in moist heat and having viscoelastic properties such that Tan? at a frequency of 1 Hz is less than or equal to 1.10. A method for producing the hydrogel, to a kit containing the hydrogel, as well as to the use thereof in dermatology are also described.
    Type: Application
    Filed: May 14, 2010
    Publication date: May 3, 2012
    Applicant: ANTEIS S.A.
    Inventors: Samuel Gavard Molliard, Cyrille Vinchon
  • Publication number: 20120107415
    Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.
    Type: Application
    Filed: November 14, 2009
    Publication date: May 3, 2012
    Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
  • Publication number: 20120087961
    Abstract: The invention relates to agents which combat the hepatitus A virus, containing only minimal amounts of chlorine-containing and/or chlorine cleaving active ingredients, or none of said substances. The inventions also relates to the use of these agents and to a method for their production.
    Type: Application
    Filed: September 22, 2011
    Publication date: April 12, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Friedrich Von Rheinbaben, Holger Biering, Klaus-Peter Bansemir, Sabine Glaeser
  • Publication number: 20120077880
    Abstract: The invention relates to highly concentrated, spherical, biopolymer gel particle suspensions comprising particle of defined particle diameter range (e.g., 1 to 50?) and process for preparing the suspensions utilizing high internal phase emulsion as intermediate.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 29, 2012
    Applicant: CONOPCO, INC., D/B/A UNILEVER
    Inventors: Congling Quan, Teanoosh Moaddel, Badreddine Ahtchi-Ali
  • Publication number: 20120077881
    Abstract: The invention relates to process for making highly concentrated, spherical biopolymer gel particle suspensions comprising particles of defined particle diameter (e.g., range of 1 to 50?) utilizing high internal phase emulsion as an intermediate.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 29, 2012
    Applicant: CONOPCO, INC., D/B/A UNILEVER
    Inventors: Congling Quan, Teanoosh Moaddel, Badreddine Ahtchi-Ali
  • Publication number: 20120053133
    Abstract: A novel antiseptic agent composition which has a wide antimicrobial spectrum and excellent antiseptic properties is provided. An antiseptic agent composition A contains a glycerin hydroxy fatty acid monoester that is an ester of glycerin and a hydroxy fatty acid having 8 to 18 carbon atoms, and a specific antiseptic agent such as an alkanediol. An antiseptic agent composition B contains the glycerin hydroxy fatty acid monoester and an aromatic antiseptic agent. An antiseptic agent composition C contains the glycerin hydroxy fatty acid monoester and a chelating agent.
    Type: Application
    Filed: January 18, 2010
    Publication date: March 1, 2012
    Applicant: TAIYO CORPORATION
    Inventors: Shuji Kanatani, Soota Iwamoto
  • Patent number: 8124115
    Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: February 28, 2012
    Assignee: DEP IP Limited
    Inventors: Marcel Veeger, Markus Himming
  • Publication number: 20120045483
    Abstract: The current invention provides new methods and means for the prevention and treatment of ageing-related symptoms and diseases. The invention discloses Mannitol 5 and/or proline containing compositions that are particularly useful for the treatment of premature ageing related symptoms in mammalian subjects suffering from genetic defects in DNA damage response and genome maintenance pathways. Humans suffering from Cockayne syndrome (CS), Xerodema pigmentosum (XP), combined XPCS, trichothiodystrophy (TTD), COFS (cerebro-oculo-facio-skeletal syndrome), 10 XFE disorder (Xpf-Erccl syndrome), Bloom Syndrome (BS), Werner Syndrome (WS), Ataxia telangiectasia (AT), Fanconi Anemia (FA), Hutchinson Guilford Progeria (HGP) may be treated with pharmaceutical compositions comprising mannitol and/or proline according to this invention.
    Type: Application
    Filed: September 6, 2011
    Publication date: February 23, 2012
    Applicant: ERASMUS MC
    Inventors: Gijsbertus van der Horst, Jan Hoeijmakers, Ingrid van der Pluijm
  • Publication number: 20120035141
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 9, 2012
    Applicant: ESPERION THERAPEUTICS, INC.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20120034293
    Abstract: The present invention overcomes the problems associated with existing drug delivery systems by delivering cannabinoids transdermally. Preferably, the cannabinoids are delivered via an occlusive body (i.e., a patch) to alleviate harmful side effects and avoid gastrointestinal (first-pass) metabolism of the drug by the patient.
    Type: Application
    Filed: October 12, 2011
    Publication date: February 9, 2012
    Applicant: AllTranz Inc.
    Inventors: Audra L. Stinchcomb, Buchi N. Nalluri
  • Publication number: 20120035273
    Abstract: The invention relates to a pharmaceutical composition comprising a combination of glycerol, white soft paraffin and liquid paraffin as active ingredients for topical use to treat uremic xerosis and/or uremic pruritus.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 9, 2012
    Applicant: ORFAGEN
    Inventor: Patrick Dupuy
  • Patent number: 8110214
    Abstract: A method of feeding a ruminant that entails providing a feed that comprises sugar alcohol and at least one additional feed component, where the feed is free of rumen-protected fatty acid or comprises less than 10 weight percent rumen-protected fatty acid, based on the total weight of the feed and further entails orally supplying the feed to the ruminant during a pre-partum period when the ruminant is pregnant, where the ruminant ingests the feed and sugar alcohol during the pre-partum period.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 7, 2012
    Assignee: Land O'Lakes Purina Feed LLC
    Inventors: Paul A. Porter, Cindie M. Luhman
  • Publication number: 20120028914
    Abstract: A pharmaceutical composition including proton pump inhibitors and prebiotics is proposed for the treatment of gastric and duodenal ulcer, this allowing effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics. The comprehensive treatment of ulcer disease associated with a helicobaterial infection using a pharmaceutical composition of a PPI and a prebiotic makes it possible, in conditions of an elevated pH of the stomach contents, actively to stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially to increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment.
    Type: Application
    Filed: April 23, 2010
    Publication date: February 2, 2012
    Inventors: Aleksander Vladimirovich Dikovskiy, Oleg Valentinovich Dorozhko
  • Publication number: 20120021072
    Abstract: The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and methods of use thereof.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 26, 2012
    Applicant: Aciex Therapeutics, Inc.
    Inventors: Matthew Jonathan Chapin, Mark Barry Abelson, Keith Jeffrey Lane, Akimitsu Makino
  • Publication number: 20120009280
    Abstract: A method of producing an animal feed product from a wet biological material, having a physical form selected from solutions, suspensions, emulsions, gums, mousses, sludges, slurries, and particulate materials, includes the step of combining the biological material with a base comprising a metal oxide in an amount which is sufficient to heat the biological material to a temperature of above 50° C. by reaction of water in the biological material with the metal oxide to produce the animal feed product. The product has a physical form which is easier to handle than that of the wet biological material and is selected from particulate materials and, granular materials. The base is preferably calcium oxide.
    Type: Application
    Filed: March 12, 2010
    Publication date: January 12, 2012
    Applicant: Bio-Energy Ingredients Limited
    Inventors: Richard Alwyn Houseman, Abraham Christo Venter
  • Patent number: 8092846
    Abstract: The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
    Type: Grant
    Filed: February 26, 2005
    Date of Patent: January 10, 2012
    Assignee: Metaproteomics, LLC
    Inventors: John G. Babish, Matthew L. Tripp, Jeffrey S. Bland
  • Publication number: 20120003158
    Abstract: The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of inflammatory bowel disease, methods for distinguishing between inflammatory bowel diseases, methods of determining predisposition to inflammatory bowel disease, methods of monitoring progression/regression of inflammatory bowel disease, methods of assessing efficacy of compositions for treating inflammatory bowel disease, methods of screening compositions for activity in modulating biomarkers of inflammatory bowel disease, methods of treating inflammatory bowel disease, as well as other methods based on biomarkers of inflammatory bowel disease.
    Type: Application
    Filed: April 8, 2011
    Publication date: January 5, 2012
    Inventors: Danny ALEXANDER, Jeffrey SHUSTER, Joshua KORZENIK, Garrett ZELLA
  • Patent number: 8088742
    Abstract: The disclosure discusses polyol-glycoside compositions for topical use. The invention provides compositions containing an efficient amount of polyol-glycoside obtained from the acetalization of a polyol with a reducing sugar. Applications for the composition include cosmetics, pharmaceuticals, and textile treatments.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: January 3, 2012
    Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques (SEPPIC)
    Inventors: Corinne Stoltz, Christine Garcia, Jean-Pierre Boiteux, Hervé Rolland, Guy Tabacchi, Alain Milius
  • Publication number: 20110319790
    Abstract: Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol/water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl sulfate or oleic acid. Further provided is a system for transfetal membrane transport. The system includes a probe unit adapted for insertion into a female reproductive tract and releasing a substance onto fetal membranes that permeabilizes the membranes. The system is also configured to apply ultrasound radiation to the fetal membranes to further increase the membrane permeability.
    Type: Application
    Filed: November 25, 2009
    Publication date: December 29, 2011
    Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.
    Inventors: Joseph Kost, Mordechai Halak, Drora Shmilovitch, Tamar Triatel, Rivka Goldbart, Aharon Azaguri, Lior Wollach
  • Publication number: 20110312904
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Application
    Filed: August 27, 2009
    Publication date: December 22, 2011
    Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20110300085
    Abstract: The present invention relates to home and personal care compositions comprising a silicone oil-in-water emulsion stabilized by a protein or peptide and at least one home and/or personal care ingredient. Such compositions tend to provide desirable characteristics for the care and conditioning of hair, skin and fabric.
    Type: Application
    Filed: October 30, 2009
    Publication date: December 8, 2011
    Inventors: Emilie Courbon, Lorry Deklippel, Tatiana Dimitrova, Anne-Lise Girboux, Sophie Hanssens, Stephane Ugazio
  • Patent number: 8071654
    Abstract: Methods and compositions employing as active ingredient hepoxilins and hepoxilin analog useful for inhibiting thromboxane formation and antagonizing thromboxane activity. Methods and compositions employing these compounds provide treatment for a number of disease conditions.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: December 6, 2011
    Inventor: Cecil R. Pace-Asciak
  • Patent number: 8048996
    Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: November 1, 2011
    Assignees: Postech Foundation, Postech Academy-Industry Foundation
    Inventors: Sung-Kee Chung, Kaustabh Kumar Maiti, Woo Sirl Lee, Ock-Youm Jeon, Seok-Ho Lee
  • Patent number: 8048897
    Abstract: A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: November 1, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroharu Matsuoka, Tsutomu Sato, Masahiro Nishimoto, Nobuo Shimma
  • Publication number: 20110262512
    Abstract: The liquid composition of the present invention contains 0.01 to 1 wt % of a nonionic surfactant (a), 0.05 to 1 wt % of a dihydric alcohol having 2 to 4 carbon atoms (b), and 30 to 70 wt % of ethanol (c), the nonionic surfactant (a) is at least one selected from the group consisting of alkyl ether type nonionic surfactants and polyoxyethylene hydrogenated castor oil type nonionic surfactants, the mole number of ethylene oxide per mole of the nonionic surfactant (a) being 20 to 100, and the HLB value of the nonionic surfactant (a) being 13 to 20.
    Type: Application
    Filed: November 18, 2009
    Publication date: October 27, 2011
    Inventors: Takeshi Bandoh, Takahiro Ueda, Misaki Ishida, Yoshihito Oda, Satomi Teraoka
  • Patent number: 8044104
    Abstract: Provided is an aqueous liquid preparation comprising: (a) any one of a prostaglandin derivative being represented by the following formula (I), a pharmaceutically acceptable salt thereof and a hydrate thereof; and (b) at least one polyol of glycerin, propylene glycol, dipropylene glycol and 1,3-butylene glycol.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: October 25, 2011
    Assignee: Taisho Pharmaceutical Co., Ltd
    Inventors: Kaori Nishizaki, Takayuki Sato, Kentaro Goto, Kuniaki Ishii
  • Publication number: 20110250154
    Abstract: Cosmetic methods and compositions for preventing or reversing damage caused to the skin of a subject by environmental pollution and/or UV radiation, the methods and compositions comprising isolated polyhydroxylated fatty alcohols or derivatives thereof for topical application, in an amount effective to prevent or reverse the harmful effects of environmental pollution and/or UV radiation on the skin e.g. by reducing the damage to the skin cells and/or improving the aesthetic appearance of human skin.
    Type: Application
    Filed: September 8, 2009
    Publication date: October 13, 2011
    Inventors: Shai Meretzki, Gennady Rosenblat, Joseph Segal
  • Publication number: 20110217247
    Abstract: The present invention provides novel topically-applied skin and face coating and paint compositions comprising near infrared reflecting pigments and hydrogels swollen with aqueous solution and/or with simulated sweat. The invention further provides methods of making and using the compositions. The novel compositions protect the skin of the wearer from damage due to intense external heat or thermal flux and simultaneously divert thermal energy to a complementary evaporative cooling mechanism. The compositions protect skin from external thermal fluxes, conform to skin chemistry, and are easy to apply and remove.
    Type: Application
    Filed: March 1, 2011
    Publication date: September 8, 2011
    Inventors: Robert Yeats Lochhead, Janice Paige Buchanan, Laura Lynn Anderson, Nicole Marie Mackey
  • Publication number: 20110217251
    Abstract: Therapeutic compositions comprising pharmaceutically effective amounts of isolated polyhydroxylated fatty alcohols, in particular suitable for topical or systemic administration. A method for the isolation of a natural polyhydroxylated fatty alcohol from a fruit or vegetable source is also disclosed.
    Type: Application
    Filed: September 8, 2009
    Publication date: September 8, 2011
    Inventors: Shai Meretzki, Gennady Rosenblat, Joseph Segal
  • Patent number: 8002830
    Abstract: Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: August 23, 2011
    Assignee: Georgia Tech Research Corporation
    Inventors: Barbara D. Boyan, Stephen J. Kennedy, Zvi Schwartz
  • Publication number: 20110201692
    Abstract: The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as hospital equipment, pipelines etc.
    Type: Application
    Filed: April 27, 2011
    Publication date: August 18, 2011
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Issam Raad
  • Publication number: 20110196383
    Abstract: A method and chemical composition for modifying and dissolving atherosclerotic plaques formed in a patient's blood vessels is provided. A chemical composition comprising one or more of an organic substance, an inorganic substance, and a bioactive substance is administered at sites of the plaques. The chemical composition comprises one or more of d-limonene, propylene glycol, octanoic acid, 2-octane, glycerine, acetylsalicylic acid, acetic acid, omega-3 fatty acids, ethanol, methanol, ezetimibe, rosuvastatin, resveratrol, lactic acid, gluconic acid, chloroform, carbon disulfide, dichloromethane, toluene, lauryldimethyl hydroxysultaine, and any combination thereof. The chemical composition enables modification of plaques by altering their composition. The modification comprises partial dissolution, complete dissolution, or elimination of the plaques, and makes the plaques amenable to different forms of plaque treatment. The modified plaques are eliminated from the patient's body.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 11, 2011
    Inventors: Kusai Saadeldin Aziz, Gary Michael Saxton
  • Publication number: 20110183011
    Abstract: Disclosed herein is a composition containing a high concentration of PG is unexpectedly capable of quickly killing other bacteria, fungi, and/or virus in vitro that is indicative of its potential high efficacy in treating various skin infection. Embodiments disclosed herein relate to a composition and method for effective topical treatment of inflammatory skin lesions in mammals, comprising of a high concentration of propylene glycol alone, or in combination with an astringent. The PG at high concentrations can be regarded as an extremely effective, safe, topical, universal, microbicide.
    Type: Application
    Filed: April 5, 2011
    Publication date: July 28, 2011
    Applicant: WINLIND SKINCARE LLC
    Inventor: WIN L. CHIOU
  • Publication number: 20110171311
    Abstract: The present specification generally relates to hydrogel compositions and methods of treating a soft tissue condition using such hydrogel compositions.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 14, 2011
    Applicant: ALLERGAN INDUSTRIE, SAS
    Inventors: Cecile GOUSSE, Pierre F. LEBRETON, Nicolas PROST
  • Patent number: 7973084
    Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, it can be effectively used in delivering various biologically active molecules, such as doxorubicin and paclitaxel to target cells.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: July 5, 2011
    Assignee: Postech Academy-Industrial Foundation
    Inventors: Sung-Kee Chung, Woo Sirl Lee, Kaustabh Kumar Maiti
  • Publication number: 20110147259
    Abstract: Compositions and methods are disclosed for stabilizing glycerin-in-oil emulsions, which can be used to significantly reduce thermal instability or instability over time compared to traditional cosmetics or topical formulations. The compositions comprise one or more oil-soluble rheological modifiers and optionally one or more emulsifiers in a glycerin-in-oil emulsion.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Applicant: Avon Products, Inc.
    Inventors: David Alan Binder, Bing C. Mei, Thi N. Do, George Willms, Hossein A. Baghdadi