Polycyclo Ring System Patents (Class 514/765)
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Patent number: 6955804Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: September 22, 2003Date of Patent: October 18, 2005Assignee: Applied Genetics Incorporated DematicsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6852328Abstract: A method and device are disclosed which prevents the decay and deterioration of wooden objects caused by pests by using a controlled release device. This controlled release device utilizes polymers which incorporate pesticides. In the disclosed method, the controlled release device is placed in contact with the wood of the wooden object. The pesticide is gradually released from the device and absorbed into the wood structure. The pesticide absorbed by the wood creates a barrier or an exclusion zone to penetration by inserts. The controlled release device maintains a minimal effective level of pesticide in the barrier or exclusion zone for a predetermined period of time.Type: GrantFiled: December 20, 1996Date of Patent: February 8, 2005Assignee: Battelle Memorial Institute K1-53Inventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton
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Publication number: 20040253286Abstract: A new use for chemicals paradichlorobenzene (10) and naphthalene (20), colorless or white, volatile crystals with a strong coal tar odor, that when positioned in areas where birds gather or roost, such as rooftops, eaves or ledges, diffuses into the surrounding air resulting in birds being deterred from affected area.Type: ApplicationFiled: June 11, 2003Publication date: December 16, 2004Inventors: Robert J. Pado, Christine Linda Hemphill
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Patent number: 6818638Abstract: Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions.Type: GrantFiled: July 11, 2002Date of Patent: November 16, 2004Assignee: Novartis AGInventors: Rolf Baenteli, Wilfried Bauer, Sylvain Cottens, Claus Ehrhardt, Ulrich Hommel, Jörg Kallen, Josef Gottfried Meingassner, François Nuninger, Gabriele Weitz Schmidt
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Patent number: 6756375Abstract: The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2CH2—; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2, R3 and R4 are independently H, halogen, —CF3, —OCF3, (1C-8C)Alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-4C)aType: GrantFiled: July 24, 2003Date of Patent: June 29, 2004Assignee: Akzo Nobel N.V.Inventors: Gerrit Herman Veeneman, Hubert JanJozef Loozen, Jordi Mestres, Eduard Willem De Zwart
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Publication number: 20030228375Abstract: This invention provides compositions and methods related to the administration of deer antler, one or more nor-testosterone precursors, and one or more testosterone precursors, to increase testosterone levels, treat sexual dysfunction, improve sexual function, improve energy, enhance feelings of well-being and increase muscle mass in males. This invention also provides for inhibitors of the enzymes aromatase and/or 5-alpha reductase, to support testosterone levels and avoid undesirable metabolites.Type: ApplicationFiled: April 25, 2002Publication date: December 11, 2003Applicant: A. Glenn BraswellInventor: Inna Yegorova
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Publication number: 20030203043Abstract: This invention provides compositions and methods related to the administration of deer antler, one or more nor-testosterone precursors, and one or more testosterone precursors, to increase testosterone levels, treat sexual dysfunction, improve sexual function, improve energy, enhance feelings of well-being and increase muscle mass in males. This invention also provides for inhibitors of the enzymes aromatase and/or 5-alpha reductase, to support testosterone levels and avoid undesirable metabolites.Type: ApplicationFiled: April 25, 2002Publication date: October 30, 2003Inventor: Inna Yegorova
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Publication number: 20030203975Abstract: A compound is provided having the formula: 1Type: ApplicationFiled: December 18, 2000Publication date: October 30, 2003Inventors: David John Mincher, Agnes Turnbull
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Publication number: 20030186946Abstract: Methods of preventing amyloid associated disease comprising preventing protofibril formation using polycyclic compounds related screens and methodologies disclosed.Type: ApplicationFiled: January 29, 2003Publication date: October 2, 2003Inventors: Garth James Smith Cooper, Kerry Martin Loomes, Jacqueline Fiona Aitken
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Patent number: 6627177Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vivo in aqueous media. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.Type: GrantFiled: December 5, 2000Date of Patent: September 30, 2003Assignee: The Regents of the University of CaliforniaInventors: Bakthan Singaram, Ritchie A. Wessling
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Patent number: 6623724Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 23, 2003Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Publication number: 20030162727Abstract: CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs is disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclitaxel, flutamide, tamoxifen, mitoxantrone, doxorubicin or daunomycin).Type: ApplicationFiled: December 9, 2002Publication date: August 28, 2003Inventors: Graeme Ian Murray, William Thomas Melvin, Morag McFadyen
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Patent number: 6610890Abstract: Medicaments for treating diabetic complications contain a compound of formula (A), wherein at least one Y or one Y′ is OH, and the remainder are selected from H, Hal, OH, OMe and NO2; X is O, S, keto or a direct linkType: GrantFiled: January 7, 2002Date of Patent: August 26, 2003Assignee: O.N.C.E.-(Organizacion Nacional De Cicgos)Inventors: Teresa Garcia de Quesada Fort, Jesús A De La Fuente Blanco, Ma Jesús Martin Lopez, Isabel Reymundo Cuesta
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Publication number: 20030133945Abstract: The present invention is a food supplement for a human body's natural immune function, formed from natural occurring substances in the form of a broth.Type: ApplicationFiled: January 11, 2002Publication date: July 17, 2003Inventor: Michael Donald Farley
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Publication number: 20030099728Abstract: An anti-aromatase pharmaceutical composition, consisting of in capsule or dose to containType: ApplicationFiled: June 21, 2001Publication date: May 29, 2003Inventor: Michael Donald Farley
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Patent number: 6566405Abstract: Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alpinia galanga (Zingiberaceae) show synergistic effects with respect to immunomodulation, and they significantly suppress hypersensitivity reactions. Thus they are used for preparing medicaments for these purposes and, more specifically, for the treatment or prevention of IgE mediated allergic reactions and conditions, such as asthma, allergic rhinitis, a topic eczema or anaphylaxis, and autoimmune disorders, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis or psoriasis, as well as for the alleviation of pain. They can for example be formulated into pharmaceuticals, cosmetics or dietary supplements. A method of preparing such compositions from Alpinia galanga is also described.Type: GrantFiled: August 6, 1999Date of Patent: May 20, 2003Assignee: Eurovita A/SInventors: Morten Sloth Weidner, Morten Just Petersen, Nina Worm Jensen
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Publication number: 20030069265Abstract: The invention provides therapeutic and biological uses of chemokine-receptor-binding compounds (including chemokine receptor ligands such as chemokine receptor agonists or antagonists), such as tricyclic phenanthrene derivatives, including uses in the treatment of disease states mediated by chemokines. The relevant chemokines may for example be monocyte chemoattractant protein-one (MCP-1) or interleukin-8 (IL-8), and the relevant chemokine receptors may for example be corresponding chemokine receptors (CCR-2, CCR-4, CXCR-1, and CXCR-2). In other aspects, the invention provides corresponding pharamaceutical compositions and therapeutic methods. In one aspect, for example, the invention provides for the use of phenanthrene-9,10-dione in the treatment of multiple sclerosis.Type: ApplicationFiled: January 22, 2001Publication date: April 10, 2003Inventors: Geeta Saxena, Christopher R. Tudan, Hassan Salari
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Patent number: 6521670Abstract: A method and composition for controlling insects is disclosed. A method and composition are most effective for killing insect populations in enclosed spaces, although direct contact with insects may also be effective. The method involves exposing the insects to 1,4-dimethylnaphthalene for a sufficient period of time to cause death to the same, wherein the insects may then be more readily destroyed. In enclosed spaces which are to be disinfected, a mist or vapor of 1,4-dimethylnaphthalene may be diffused into the space with the space sealed for a sufficient period of time to eliminate insects.Type: GrantFiled: September 8, 2000Date of Patent: February 18, 2003Assignee: BioAdvantage, Inc.Inventors: Darol Forsythe, John M. Forsythe, Ralph I. Freudenthal
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Patent number: 6506370Abstract: Disclosed is a safe and effective hair-growing agent comprising a protein kinase C-specific inhibitor.Type: GrantFiled: March 24, 1997Date of Patent: January 14, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoya Takahashi, Yoshiharu Yokoo, Toshikazu Kamiya, Akio Shirai, Tatsuya Tamaoki
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Publication number: 20020160066Abstract: An essential oil composition from Coleus forskohlii is used in compositions and methods for the treatment of skin infections and in the prevention and treatment of dental caries.Type: ApplicationFiled: February 20, 2002Publication date: October 31, 2002Inventors: Muhammed Majeed, Subbalakshmi Prakash
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Patent number: 6403536Abstract: A chemical composition and method useful in the treatment of stored potatoes is disclosed. The chemical composition includes a mixture of a substituted naphthalene compound and an odor-neutralizing ingredient. The instant invention also discloses a method for reducing the odor of naturally-occurring or applied substituted naphthalenes. The odor-neutralizing ingredient neutralizes the odor associated with substituted naphthalene compounds.Type: GrantFiled: May 18, 2000Date of Patent: June 11, 2002Inventors: Darol Forsythe, John M. Forsythe
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Patent number: 6375999Abstract: A sprout inhibitor for potatoes is introduced into a potato storage facility as a gas phase carried in an air stream. The liquid sprout inhibitor may be heated prior to injection into a flowing air stream or a large surface area of the liquid sprout inhibitor may be exposed to the air stream to induce evaporation of the inhibitor into a gaseous phase. Sprout inhibitors such as dimethylnaphthalene (DMN) and trimethylnaphthalene are especially suitable for introduction to potato storage sheds by thermal fogging or evaporative fogging. A method and composition to promote healing of freshly dug potatoes are further disclosed. Treatment of freshly dug potatoes with DMN either prior to or immediately after storage promotes rapid healing of cuts, abrasions and similar injuries to the potatoes. Stored potatoes first treated with DMN may be later advantageously treated with low levels of CIPC for effective sprout inhibition.Type: GrantFiled: January 4, 2000Date of Patent: April 23, 2002Inventors: Darol Forsythe, John M. Forsythe
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Patent number: 6365625Abstract: This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.Type: GrantFiled: September 17, 1999Date of Patent: April 2, 2002Assignee: Procept, Inc.Inventors: Shyam K. Singh, Raymond J. Patch, Peter V. Pallai, Edith A. Neidhardt, Gerard P. Palace, Kevin J. Willis, Theresa M. Sampo, Kevin W. McDonald, Zhan Shi
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Patent number: 6352703Abstract: Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.Type: GrantFiled: June 7, 2000Date of Patent: March 5, 2002Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gregg Henderson, Jian Chen, Roger A. Laine
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Publication number: 20020010168Abstract: The invention concerns the use of pure boswellic acid, a physiologically acceptable salt, a derivative, a salt of the derivative or a plant preparation containing boswellic acid for preventing and/or combatting diseases which are caused by increased leucocytic elastase or plasmin activity or can be treated by the inhibition of normal leucocytic elastase or plasmin activity, in human or veterinary medicine.Type: ApplicationFiled: June 15, 1998Publication date: January 24, 2002Inventors: HERMANN P.T. AMMON, HASAN SAFAYHI
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Patent number: 6337411Abstract: Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of conditions whose course involves an increased activity of matrix-degrading enzymes, in particular stromelysin.Type: GrantFiled: December 15, 2000Date of Patent: January 8, 2002Assignee: Aventis Pharma Deutschland GmbHInventors: Cordula Hopmann, Martin Albert Knauf, Klaus-Ulrich Weithmann, Joachim Wink
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Patent number: 6337078Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.Type: GrantFiled: December 10, 1999Date of Patent: January 8, 2002Assignee: Lee County Mosquito Control DistrictInventor: Richard Levy
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Patent number: 6319949Abstract: A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent is a mixture of aliphatic hydrocarbons having a distillation range of about 520 to 600° F. and an aromatic content of about 1% or less, or the solvent is a single or combination of C6-C18 fatty alcohol(s); and (b) applying chlorothalonil to the crop previously to, simultaneously with, or subsequently to the application of the aqueous spray composition, wherein phytotoxicity associated with the application of chlorothalonil is reduced or eliminated.Type: GrantFiled: November 4, 1996Date of Patent: November 20, 2001Assignee: Syngenta LimitedInventors: Jeffrey R. Schussler, Robert E. Moser, Kevin E. Crosby, John R. Washington
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Patent number: 6300376Abstract: Indane dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity are described.Type: GrantFiled: June 8, 1998Date of Patent: October 9, 2001Assignee: Venantius LimitedInventors: John Walsh, Neil Frankish, Helen Sheridan, Ronan Farrell, William Byrne
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Patent number: 6290937Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 18, 2001Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6251953Abstract: Methods for raising or maintaining the level of T4 cells in humans having a depressed T4 cell level and particularly in humans infected with HIV are provided. In these embodiments, T4 enhancing amounts of beta-carotene are administered. Methods are also provided for lowering or maintaining the levels of neopterin and/or &bgr;2-microglobulin in humans having elevated levels of these indices and particularly in those infected with HIV. Beta-carotene is administered, respectively, in neopterin and &bgr;2-microglobulin therapeutically effective amounts. Also contemplated by the present invention are methods for the prevention and/or treatment of HIV infection in humans. An HIV infection preventing or an anti-HIV therapeutically effective amount of beta-carotene is administered. In another embodiment, methods are provided for preventing or treating AIDS in humans. An AIDS preventing amount or an anti-AIDS therapeutically effective amount of beta-carotene is administered.Type: GrantFiled: October 11, 1994Date of Patent: June 26, 2001Inventor: Steven Baranowitz
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Patent number: 6245774Abstract: Compounds of general formula (1) are described: wherein ═W— is (1) ═C(Y)— where Y is a halogen atom, or an alkyl or —XRa group where X is —O—, —S(O)m— [where m is zero or an integer of value 1 or 2], or —N(Rb)— [where Rb is a hydrogen atom or an optionally substituted alkyl group] and Ra is a hydrogen atom or an optionally substituted alkyl group or, (2) ═N—; L is (1) a —C(R)═C(R1)(R2) or [—CH(R)]nCH(R1)(R2) group; is (2) a —(Xa)nAlk′Ar′, or Alk′XaAr′ group; or is (3) XaR1; Z is a group (A), (B), (C) or (D): wherein Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; Z1is a group —NR12C(O)— [where R12 is a hydrogen atom or an optionally substituted alkyl or (Alk)tAr group], —C(O)NR12—, —NR12Type: GrantFiled: June 20, 1995Date of Patent: June 12, 2001Assignee: Celltech Therapeutics LimitedInventors: Graham John Warrellow, Ewan Campbell Boyd, Rikki Peter Alexander
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Patent number: 6197833Abstract: A method is provided for conferring neuroprotection on a population of cells in a subject, the method including providing a polycyclic compound having a terminal phenolic group in a structure containing at least a second ring, the compound having a molecular weight of less than 1000 Daltons, the compound not including estrogen compounds including estrogen agonists. The compound may be administered in an effective dose to the population of cells so as to confer neuroprotection. Methods are further provided for treating a neurodegenerative disease in a subject that include providing an effective dose of a formulation containing the compound and administering the dose to the subject.Type: GrantFiled: August 4, 1998Date of Patent: March 6, 2001Assignees: Apollo Biopharmaceutics, Inc., University of Florida Research Foundation, Inc.Inventors: James W Simpkins, Katherine Gordon, Pattie S. Green
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Patent number: 6075044Abstract: The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.Type: GrantFiled: July 17, 1998Date of Patent: June 13, 2000Assignee: The Regents of the University of CaliforniaInventors: Ching C. Wang, John Somoza, Jon P. Page, Ronaldus Marcellus Alphonsus Knegtel, Irwin D. Kuntz, Connie M. Oshiro, A. Geoffrey Skillman
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Patent number: 6075017Abstract: Seborrheic dermatitis of the scalp is treated by a synergistic combination of a cytotoxic agent and an antifungal agent.Type: GrantFiled: January 7, 1998Date of Patent: June 13, 2000Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.Inventors: Avi Dascalu, Yoram Oron
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Patent number: 6028117Abstract: Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.Type: GrantFiled: December 18, 1996Date of Patent: February 22, 2000Assignee: S. C. Johnson & Son, Inc.Inventor: John D. Hagarty
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Patent number: 6017879Abstract: The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.Type: GrantFiled: April 3, 1998Date of Patent: January 25, 2000Assignee: B.M.R.A. Corporation B.V.Inventors: Manfred Mutter, Jean-Silvain Lacroix, Eric Grouzmann
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Patent number: 6001874Abstract: A non-toxic arthropod control composition is disclosed for application to foliage for plant protection. The composition includes behavior interfering compounds, agricultural oil and/or surface active compounds and diluents. The behavior interfering compounds may be any known conventional compound capable of interrupting or altering the normal behavioral sequences of the target. The agricultural oil can be a vegetable oil.Type: GrantFiled: June 20, 1997Date of Patent: December 14, 1999Inventor: Dan Veierov
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Patent number: 5856315Abstract: The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of 7-?substituted amino!-9-?(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.Type: GrantFiled: May 26, 1998Date of Patent: January 5, 1999Assignee: American Cyanamid CompanyInventors: Joseph M. Backer, Peter Bohlen
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Patent number: 5852060Abstract: A psoriasis treatment composition derived from the plant Asphodelus Microcarpus includes 3-methylanthralin, chrysophanol, aloe-emodin, aloe-emodin monoacetate, and/or derivatives thereof. The composition is prepared by extracting a liquid from the Asphodelus Microcarpus root and mixing the liquid with acetic acid. A method of treatment includes applying the composition to an affected area of skin at a frequency sufficient to effect an alleviation of symptoms, typically once per day for 14-56 days.Type: GrantFiled: May 1, 1997Date of Patent: December 22, 1998Inventors: Marzook Moady, deceased, by Said Moady, executor
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Patent number: 5843925Abstract: The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-?substituted amino!-9-?(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.Type: GrantFiled: December 13, 1994Date of Patent: December 1, 1998Assignee: American Cyanamid CompanyInventors: Joseph M. Backer, Peter Bohlen
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Patent number: 5834521Abstract: Tetracyclic compounds having the following structure are described: ##STR1## wherein R.sub.1 -R.sub.10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.Type: GrantFiled: August 5, 1996Date of Patent: November 10, 1998Assignee: Ortho Pharmaceutical CorporationInventors: John H. Dodd, Lisa A. Dixon, James L. Bullington, Charles F. Schwender
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Patent number: 5814325Abstract: Closely related formulations of GRAS food additives serve as insect repellents, insecticides and larvicides. The ingredients of the repellent, insecticide and larvicide also exhibit useful disinfectant properties against vector-borne pathogenic micro-organisms.Type: GrantFiled: April 11, 1997Date of Patent: September 29, 1998Assignee: The Rod Family TrustInventor: Robert L. Rod
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Patent number: 5776891Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.Type: GrantFiled: June 7, 1995Date of Patent: July 7, 1998Assignee: Rush Prebyterian-St. Luke Medical CenterInventors: John S. Coon, Mannarsamy Balasubramanian, R. Martin Emanuele, Himanshu Shah
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Patent number: 5681812Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.Type: GrantFiled: May 19, 1995Date of Patent: October 28, 1997Assignee: Rush Presbyterian-St. Luke's Medical CenterInventors: John S. Coon, Mannarsamy Balasubramanian, R. Martin Emanuele, Himanshu Shah
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Patent number: 5677343Abstract: This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalene-sulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.Type: GrantFiled: June 6, 1995Date of Patent: October 14, 1997Assignee: Procept, Inc.Inventors: Shyam K. Singh, Raymond J. Patch, Peter V. Pallai, Edith A. Neidhardt, Gerard P. Palace, Kevin J. Willis, Theresa M. Sampo, Kevin W. McDonald, Zhan Shi
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Patent number: 5668184Abstract: A method of repelling soil borne pests, nematodes, insects and insect larvae includes applying a solution of naphthalene or precipitated flocculent naphthalene into or upon the soil where the naphthalene volatilizes and repels nematodes and soil pathogens. In another embodiment of the invention, micron size particles of naphthalene are encapsulated in a polymer which is injected into or applied to the surface of the soil. In a further embodiment of the invention, micron-sized particles of naphthalene are attached to a carrier strip which is applied to the surface of the soil as a mulch, applied below the surface of the soil, or attached to trees or plants for repelling pests.Type: GrantFiled: September 6, 1996Date of Patent: September 16, 1997Inventor: A. H. J. Rajamannan
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Patent number: 5653991Abstract: Closely related formulations of GRAS food additives serve as insect repellents, insecticides and larvicides. The ingredients of the repellent, insecticide and larvicide also exhibit useful disinfectant properties against vector-borne pathogenic microorganisms.Type: GrantFiled: May 9, 1995Date of Patent: August 5, 1997Assignee: The Rod Family TrustInventor: Robert L. Rod
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Patent number: 5629351Abstract: Disclosed herein is a novel fraction comprising a mixture of boswellic acids, wherein the fraction exhibits anti-inflammatory and antiulcerogenic activities. Also disclosed is a novel boswellic acid compound exhibiting anti-inflammatory, antiathritic and antiulcerogenic activities. Also disclosed is a process for isolating a boswellic acid fraction and individual boswellic acids therefrom.Type: GrantFiled: April 13, 1995Date of Patent: May 13, 1997Assignee: Council of Scientific & Industrial ResearchInventors: Subhash C. Taneja, Vijay K. Sethi, Kanaya L. Dhar, Randhir S. Kapil
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Patent number: 5614559Abstract: This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalene-sulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.Type: GrantFiled: May 19, 1994Date of Patent: March 25, 1997Assignee: Procept Inc.Inventors: Shyam K. Singh, Raymond J. Patch, Peter V. Pallai, Edith A. Neidhardt, Gerard P. Palace, Kevin J. Willis, Theresa M. Sampo, Kevin W. McDonald, Zhan Shi