Designated Inorganic Nonactive Ingredient Or Elemental Material Other Than Water Patents (Class 514/769)
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Publication number: 20140309312Abstract: A method of synthesizing for an iron based magnetic composite material includes the steps of stirring together potassium hydroxide, iron (II, III) oxide, and water. The method also includes the steps of heating the resulting Fe3O4—KOH mixture for a predetermined amount of time. Further, the method includes the step of heating the Fe3O4—KOH mixture until consecutive measurements of the Fe3O4—KOH mixture are within 10% of each other. Also included in the method if adding calcium hypochlorite and mixing until a magnetic Fe(VI)/Fe3O4 composite material is formed. Additionally, the method involves preparing and analyzing the magnetic Fe(VI)/Fe3O4 composite material to determine the amount of ferrate synthesized during from the method.Type: ApplicationFiled: April 14, 2014Publication date: October 16, 2014Inventor: Bo Fan
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Publication number: 20140294948Abstract: The invention relates in one aspect to a composition, specifically a jelly, the use of which composition as an auxiliary means is to ease the taking of oral medication in solid form, which composition comprises iota-carrageenan as a jellifying agent and citric acid as a salivating agent, characterized in that the composition further comprises maltodextrin. In another aspect, the composition comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. In one embodiment, the composition comprises iota-carrageenan in 0.7-1.0% in mass, citric acid in 0.06-0.07% in mass, maltodextrin in 1.5% in mass, all relative to the total mass of the composition, and an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm.Type: ApplicationFiled: April 2, 2014Publication date: October 2, 2014Applicant: PAXTREE LTDInventor: Ron BRUIJNS
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Publication number: 20140294909Abstract: A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.Type: ApplicationFiled: October 12, 2012Publication date: October 2, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Jordan J. Green, Corey J. Bishop, Daniel Peng, Stephany Yi Tzeng
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Publication number: 20140288188Abstract: This invention discloses a process for stabilising an aqueous mineral preparation comprising a step of adding at least one aldehyde-containing and/or aldehyde-releasing and/or phenolic and/or isothiazoline biocide to said aqueous mineral preparation.Type: ApplicationFiled: November 22, 2012Publication date: September 25, 2014Inventors: Nicola Di Maiuta, Patrick Schwarzentruber
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Publication number: 20140275287Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: November 1, 2012Publication date: September 18, 2014Applicant: ABYRX, INC.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Publication number: 20140275286Abstract: In various embodiments a carbon nanotube molecular rebar formulation comprising a specific composition is disclosed. The composition comprises discrete carbon nanotubes that have at least a portion of the carbon nanotubes with a number average (ratio of number average contour length to end to end length) of greater than 1.1 and up to about 3. These discrete carbon nanotubes having the specified ratio of number average (tube contour length (TCL) to number average tube end-end length) ratio are not only discrete (separated) from one another, but are also controlled in their alignment such that processability and mechanical strength properties are both enhanced. Utility of the molecular rebar composition includes, but is not limited to improved composites, engineered materials, foams, sealants, coatings and adhesives, energy devices such as photovoltaics, batteries and capacitors, sensors and separation membranes.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Molecular Rebar Design, LLCInventors: Clive P. Bosnyak, Kurt W. Swogger
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Publication number: 20140248214Abstract: Methods of using a surface active block copolymer to disperse graphene in an aqueous medium, such dispersions which can be subsequently separated and processed for a range of end-use applications, including biomedical applications.Type: ApplicationFiled: March 14, 2013Publication date: September 4, 2014Inventors: Mark C. Hersam, Jung-Woo T. Seo, Alexander A. Green, Alexander L. Antaris
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Publication number: 20140248364Abstract: The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs.Type: ApplicationFiled: September 14, 2012Publication date: September 4, 2014Inventors: Juan Sanchez-Ramos, Vasyl Sava, Shijie Song, Shyam S. Mohapatra, Subhra Mohapatra
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Publication number: 20140242149Abstract: Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate and silicone compositions having high-density particles suspended in an adhesive gel. The silicone compositions contain a thixotropic additive, such as a hydrogenated vegetable oil. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings.Type: ApplicationFiled: October 12, 2012Publication date: August 28, 2014Applicant: Dow Corning CorporationInventors: David Gantner, Roger A. Gibas, Do-Lung Pan, Xavier Thomas, Christine A. Weber
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Publication number: 20140234220Abstract: The present disclosure relates to a method for making a gold nanoparticle dispersion. The method includes providing a first solution that has gold ions in a liquid medium, adding NTA molecules to the first solution to form a gold nanoparticle dispersion. When the NTA molecules are added to the first solution, the NTA molecules act as a reducing agent to reduce the gold ions to gold atoms, after which the gold atoms nucleate to form gold nanoparticles. The excess NTA molecules then attach to the surface of the gold nanoparticles to stabilize the dispersion. The present disclosure also relates to a dispersion composition that includes a liquid medium, gold nanoparticles dispersed throughout the liquid medium, and NTA molecules directly coating the gold nanoparticles.Type: ApplicationFiled: February 18, 2014Publication date: August 21, 2014Inventors: Dan V. Goia, John I. Njagi, Calin V. Pop
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Patent number: 8802061Abstract: The present invention is drawn to disinfectant or sterilant compositions, which are human safe, e.g., food grade, food safe, or skin safe, etc. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal or alloy thereof based on the aqueous vehicle content can also be present. The disinfectant composition can be used in the manufacture and formulation of products for human use or consumption including disinfectant mouthwashes, toothpastes, gums, ointments, and soaps.Type: GrantFiled: February 24, 2006Date of Patent: August 12, 2014Assignee: Solutions BioMed, LLCInventors: Daryl J. Tichy, Brian G. Larson
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Patent number: 8802151Abstract: The instant invention relates to shaped transition metal particles, in particular in the form of a dispersion in an aqueous and/or organic medium, the manufacture thereof and their use as an infrared (IR) absorbing agent, an IR curing agent for coatings, an additive in conductive formulations, an antimicrobial agent or for sensoring organic and/or inorganic compounds. Further, the invention relates to dispersions comprising said shaped particles and an aqueous and/or organic medium, such as a thermoplastic or crosslinkable polymer, as well as to antimicrobial compositions and products.Type: GrantFiled: March 17, 2010Date of Patent: August 12, 2014Assignee: BASF SEInventors: Nikolay A. Grigorenko, Michael Muehlebach, Florian Muehlebach
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Publication number: 20140220077Abstract: The present invention provides attenuated F. columnare strains that elicit an immune response in an animal, particularly a fish, against virulent F. columnare compositions comprising said strains, methods of vaccination against F. columnare, and kits for use with such methods and compositions. The invention further relates to a stabilization buffer, which allows the attenuated compositions to remain storage stable at ambient temperatures for extended periods of time.Type: ApplicationFiled: January 31, 2014Publication date: August 7, 2014Applicant: Auburn UniversityInventors: Oscar Olivares-Fuster, Covadonga R. Arias
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Publication number: 20140212511Abstract: The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface.Type: ApplicationFiled: March 27, 2014Publication date: July 31, 2014Applicant: The Clorox CompanyInventors: David R. Scheuing, Thomas F. Fahlen, Jared Heymann, Mike Kinsinger, William Ouellette, William L. Smith
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Publication number: 20140205664Abstract: The present invention relates to an improved process for the production of finely divided haematite and of iron oxide red pigments made up of the finely divided haematite and the use of the finely divided haematites and iron oxide red pigments produced by this process.Type: ApplicationFiled: September 28, 2012Publication date: July 24, 2014Applicant: LANXESS DEUTSCHLAND GmbHInventors: Guido Ketteler, Udo Holtmann, Juergen Kischkewitz
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Publication number: 20140206614Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.Type: ApplicationFiled: March 20, 2014Publication date: July 24, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Wouter E. Roorda, Stephen D. Pacetti
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Publication number: 20140200193Abstract: A biological thixotropic adhesive that contains dextrin, and at least a structural component that provides thixotropy to the adhesive, and optionally at least an antibiotic that is very useful to stimulate the process of healing of tissues in a patient, for example, to prevent anastomotic leaks of the gastrointestinal system, to affix a prosthesis in inguinal hernioplasties, in a patient and to oclude a fistula in a patient. The biological thixotropic dahesive also has anti-inflammatory properties and can be used with a fatty tissue patch.Type: ApplicationFiled: November 30, 2011Publication date: July 17, 2014Inventor: Jorge Cueto García
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Patent number: 8771750Abstract: A process for delivering and/or removing metal from a biological system by loading a titanate sorbent with a biometal either before introduction into the system for delivery to a site within the system or after introduction into the system for delivery to a site where there is an excess accumulation of metal and thereafter the sorbent is loaded at the site with the excess metal and is removed from the system.Type: GrantFiled: December 14, 2006Date of Patent: July 8, 2014Assignee: Savannah River Nuclear Solutions, LLCInventors: David T. Hobbs, John C. Wataha, Jill Lewis, Regina L. W. Messer
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Patent number: 8765189Abstract: Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least multivalent metal compound, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments which exhibit bond strength upon curing with the possible usage as bone cement for bone filler applications.Type: GrantFiled: May 11, 2012Date of Patent: July 1, 2014Assignee: Howmedica Osteonic Corp.Inventors: Venkat R. Garigapati, Kevor S. TenHuisen
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Publication number: 20140171319Abstract: The invention relates to a liquid aqueous composition, which has a pH value of at least 7.0, comprising a pesticide and a base selected from an alkali salt of hydrogencarbonate; a method for preparing said composition comprising a step of contacting a pesticide and a base selected from an alkali salt of hydrogencarbonate; and a method of combating harmful insects and/or phytopathogenic fungi, which comprises contacting plants, seed, soil or habitat of plants in or on which the harmful insects and/or phytopathogenic fungi are growing or may grow, plants, seed or soil to be protected from attack or infestation by said harmful insects and/or phytopathogenic fungi with an effective amount of the composition.Type: ApplicationFiled: July 17, 2012Publication date: June 19, 2014Applicant: BASF SEInventors: Gerhard Schnabel, Marc Nolte, Mariano Ignacio Etcheverry, Gerhard Genari, Thomas Kroehl, Matthias Bratz, Terrance Cannan, Steven Bowe, Chad Brommer, John Frihauf, Charles W. Finch, Walter Thomas
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Publication number: 20140134240Abstract: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ?-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.Type: ApplicationFiled: July 2, 2013Publication date: May 15, 2014Inventors: David L. Kaplan, Tuna Yucel, Tim Jia-Ching Lo, Gary G. Leisk
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Publication number: 20140135405Abstract: A water-in-silicone oil macroemulsion cosmetic composition of waterdrop quick break type is provided. The silicone oil phase part contains a partly crosslinked emulsifiable silicone elastomer, a partly crosslinked non-emulsifiable silicone elastomer, and silicone oil, and the aqueous phase part contains glycerin as a freeze stabilizer and at least one member selected from polyols and lower alcohols and/or at least one member selected from organic acid salts and inorganic salts as a mixture of freeze stabilizers. The cosmetic composition instantaneously releases water upon application on the skin. The cosmetic composition is stable at the extremely low temperature of ?20° C., and it retains its dispersion stability even after repeated freezing and thawing, and accordingly, and it can be used in a variety of cosmetic product.Type: ApplicationFiled: November 12, 2013Publication date: May 15, 2014Applicant: Shin-Etsu Chemical Co., Ltd.Inventor: Taeck-young LEE
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Publication number: 20140128476Abstract: An implant having shape forming and hardening functionality is described. The implant is formed from shape memory materials. The implant is formed from a shape memory alloy, shape memory polymer, or combinations thereof, to provide them with the ability to be compressed into a shape that facilitates minimally invasive insertion. Subsequent to such insertion, the shape memory materials provide the implant with the ability to regain its original shape and size. Subsequently, the implant becomes rigid, thereby providing strength, structural integrity and support.Type: ApplicationFiled: November 1, 2013Publication date: May 8, 2014Applicant: Boo Holdings, LLCInventor: Charles S. Theofilos
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Publication number: 20140128329Abstract: Compositions and methods related to ophthalmic use of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers and therapeutic uses are described herein.Type: ApplicationFiled: January 10, 2014Publication date: May 8, 2014Applicant: Allergan, Inc.Inventors: Anuradha V. Gore, Chetan P. Pujara, Richard S. Graham, Melissa Gulmezian, Kristin Prinn, Ramakrishnan Srikumar
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Publication number: 20140128477Abstract: The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.Type: ApplicationFiled: January 15, 2014Publication date: May 8, 2014Applicant: BPSI Holdings, LLC.Inventors: Thomas P. Farrell, Jason TECKOE
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Publication number: 20140120167Abstract: Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation-therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (GNPs), near-infrared short laser pulses, and X-rays.Type: ApplicationFiled: October 30, 2013Publication date: May 1, 2014Applicant: WILLIAM MARSH RICE UNIVERSITYInventors: Dmitri Lapotko, Katsiaryna Hleb, Michael E. Kupferman, Daniel Scudder Wagner, Vladimir Torchilin, Xiangwei Wu
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Publication number: 20140120145Abstract: A process is described herein for applying antimicrobials to substrates such as fabrics. An antimicrobial-binder mixture is provided that includes an antimicrobial and a binder that includes guar gum in an aqueous solution, which is applied to the substrate. Once the substrate is cured, spikes formed by the antimicrobial are disposed on the fabric and function to rupture membranes of infectious agents.Type: ApplicationFiled: October 26, 2012Publication date: May 1, 2014Inventor: Joseph Giovanniello
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Publication number: 20140121172Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.Type: ApplicationFiled: May 28, 2013Publication date: May 1, 2014Applicant: Run Them Sweet, LLCInventors: Michael A. Horning, George A. Brooks
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Patent number: 8703827Abstract: A foam for the treatment of varicose veins is disclosed, comprising a sclersosant solution, e.g. polidocanol, foamed with a gas mixture which includes greater than 41% of a lipid soluble gas such as xenon. The aim is to provide a foam which may be injected into a varicose vein in large quantities because the gas component is dissipated quickly after the foam has acted on the varicose vein.Type: GrantFiled: May 12, 2006Date of Patent: April 22, 2014Assignee: BTG International Ltd.Inventor: William John Jenkins
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Publication number: 20140107203Abstract: The invention relates to an oral pharmaceutical composition of isotretinoin at least two excipients, one of the excipients being a hydrophilic excipient having an HLB value greater than or equal to 10 and the other excipient being an oily vehicle. The oral pharmaceutical composition is substantially devoid of food effect as characterized by a dissolution profile wherein at least 70% of the oral pharmaceutical composition is dissolved after about four hours in a USP2 dissolution apparatus at a paddle speed of 100 rpm, and a dissolution media composed of 900 mL of pH 7.5 buffer containing 0.11% pancreatin, 4.7% cholic acid, 0.14% sodium dihydroxide phosphate and 0.5% sodium hydroxide at 37° C.Type: ApplicationFiled: December 18, 2013Publication date: April 17, 2014Applicant: GALEPHAR PHARMACEUTICAL RESEARCH, INC.Inventors: Arthur M. DEBOECK, Francis VANDERBIST, Cecile SERVAIS, Philippe BAUDIER
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Patent number: 8697107Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.Type: GrantFiled: April 27, 2012Date of Patent: April 15, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Susan J. Drapeau, Daniel A. Shimko
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Publication number: 20140099426Abstract: A solid dosage form coating composition including gray oyster shell powder in a form suitable to be coated on a solid dosage form. A method including coating a solid dosage form with a coating composition comprising gray oyster shell powder; and drying the coating composition into a film.Type: ApplicationFiled: October 10, 2012Publication date: April 10, 2014Applicant: Pharmavite LLCInventors: Linji Wang, Louis A. Morin, Douglas R. Roper, Kendall M. Downing
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Publication number: 20140099377Abstract: The invention relates to a continuous method for producing inorganic or organic nanoparticles having multiple nuclei functionalised with proteins, using a T-type reactor that operates at high pressure, the primary particles that form the nuclei of the nanoparticles being smaller than 10 nm and said primary particles being immersed in a proteinaceous matrix that forms the nanoparticle in sizes of between 30 nm and 500 nm. The invention also relates to the nanoparticles produced by means of said method.Type: ApplicationFiled: April 13, 2012Publication date: April 10, 2014Applicant: UNIVERSIDAD DE ANTIOQUIAInventors: Herley Casanova Yepes, Lina Paola Higuita Gonzalez
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Patent number: 8691287Abstract: Disclosed herein are ophthalmic cleaning systems and methods for their use, which comprise an ophthalmic solution and lens case, wherein the solution includes dual disinfectants and the lens case includes silver. When the lens case is combined with the solution according to the system of the present invention, it surprisingly exhibits synergistic activity which results in a faster antimicrobial activity.Type: GrantFiled: September 22, 2011Date of Patent: April 8, 2014Assignee: Abbott Medical Optics Inc.Inventors: Stanley W. Huth, Simon Kilvington, Simon Cheung
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Patent number: 8685465Abstract: The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 70 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; and iii) a ?-tricalcium phosphate powder having a median particle size of less than about 20 microns. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.Type: GrantFiled: August 29, 2011Date of Patent: April 1, 2014Assignee: Agnovos Healthcare, LLCInventors: Jon P. Moseley, Michael E. Carroll, Jonathan D. McCanless, Olaf Schulz, Andy Fronk
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Publication number: 20140080914Abstract: There is provided an aqueous acrylamide solution including 2,2,6,6-tetramethylpiperidine 1-oxyl in the ratio of 2 to 100 mg and manganese ions in the ratio of 0.2 to 2.0 mg per 1 kg of acrylamide. According to the present invention, an aqueous acrylamide solution having favorable quality and high stability with suppressed polymerization of acrylamide, a stabilizer used therefore, and a stabilization method can be provided.Type: ApplicationFiled: May 21, 2012Publication date: March 20, 2014Applicant: Mitsubuishi Rayon Co., Ltd.Inventors: Makoto Kanou, Norifumi Hagiya
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Publication number: 20140079630Abstract: The invention provides compositions and methods for visualizing particular tissues and delivering one or more therapeutics to that tissue using single-walled carbon nanotubes (SWNTs), which are taken up and delivered to target tissues by specific monocytes in the body. The delivery of SWNT to target tissues allows the visualization of the affected tissue for diagnostics and therapy in diseases where the specific monocyte is implicated in the disease pathogenesis. These nanotubes can be conjugated to a peptide, such as RGD, which helps direct the SWNT-containing monocytes to the vascular endothelium.Type: ApplicationFiled: September 7, 2013Publication date: March 20, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Bryan R. Smith, Eliver Ghosn
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Publication number: 20140065220Abstract: The present invention relates to a novel binder having high bondability and fluidity. The binder of the present invention has a BET specific surface area of 80 to 400 m2/g and is composed of carbonate-containing magnesium hydroxide particles represented by the following Formula (1): Mg(OH)2-x(CO3)0.5x.mH2O??(1) wherein, x and m satisfy the following requirements: 0.02?x?0.7, and 0?m?1. Even if the binder of the present invention is prescribed together with a disintegrant or a water-soluble excipient, the binder can improve the tablet hardness without elongating the disintegration time of the tablet and can be applied to direct compression.Type: ApplicationFiled: March 15, 2012Publication date: March 6, 2014Applicant: Kyowa Chemical Industry Co., Ltd.Inventor: Tomoko Tachifuji
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Publication number: 20140066511Abstract: A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissue lacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the scalp or penis. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride.Type: ApplicationFiled: October 30, 2013Publication date: March 6, 2014Applicant: Strategic Science & Technologies, LLCInventor: Eric T. Fossel
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Publication number: 20140058340Abstract: An eyelid margin wipe comprising chemical means for adjusting the temperature of the wipe relative to the ambient temperature. The wipe is particularly useful for treatment of disorders of the eyelid or eyelid margin such as meibomian gland dysfunction.Type: ApplicationFiled: July 1, 2013Publication date: February 27, 2014Applicant: OPTOMETRIC TECHNOLOGY GROUP LTD.Inventors: Michel Lucien Guillon, Cecile Adrienne Maissa
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Patent number: 8652524Abstract: An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.Type: GrantFiled: November 28, 2008Date of Patent: February 18, 2014Assignees: Hoya Technosurgical CorporationInventors: Ichiro Ono, Yoshikiyo Akasaka, Takehiko Nakajima
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Publication number: 20140030346Abstract: Provided is a core particle for a pharmaceutical preparation, capable of delivering a relatively large amount of a drug active ingredient, in particular, at a predetermined timing. This invention relates to a disintegrable core particle for a pharmaceutical preparation, which core particle is adapted for formation, on the particle surface, of a drug active ingredient-containing film, wherein (1) the core particle includes a pharmaceutically acceptable inorganic material and a disintegration promoting agent, (2) the inorganic material is poorly soluble in water, (3) the inorganic material has a content of from 50 to 95 wt %, and (4) the core particle has a bulk density of at least 0.6 g/mL.Type: ApplicationFiled: December 27, 2011Publication date: January 30, 2014Inventors: Masashi Konishi, Ariumi Kawamoto, Akira Ookubo, Masashi Yunoki
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Patent number: 8637055Abstract: The present invention present a novel and cost-effective family of cosmetic compositions comprising inter alia small magnetic particles characterized by magnetic field adapted to be topically administrated adjacent to skin surface, absorbed to epidermal upper skin layers and place in a direct contact to the body, usually above pain suffering regions. The present invention also provides the use of the compositions, especially of nano-powders of salts obtained from the Dead Sea, as an external layer of bandages, dressings, compresses or warps, so constantly approached to be in an intimate contact with the patient's skin.Type: GrantFiled: June 23, 2003Date of Patent: January 28, 2014Assignee: Ahava-Dead Sea Laboratories Ltd.Inventors: Zeev Maor, Michael Royz
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Publication number: 20140017320Abstract: A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P2O5, SiO2, and B2O3; at least about 25 wt % of the fibers have a diameter between about 200 nm and about 4000 nm, and a length:width aspect ratio of at least about 10. In another form, the glasses are in the form of particles in an ointment or cream applied to a wound. In yet other forms the glasses are employed as fibers formed into sutures for closing a wound, or as particles in a surgical glue for closing a wound.Type: ApplicationFiled: September 16, 2013Publication date: January 16, 2014Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Steven B. Jung, Delbert E. Day
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Publication number: 20140010772Abstract: A silver-colored pigment is provided having a nonmetallic platelet-shaped substrate and at least one ilmenite-containing coating, wherein the nonmetallic platelet-shaped substrate is a nonmetallic platelet-shaped synthetic substrate and the amount of iron compounds, calculated as elemental iron, in the pigment is less than 5.0% by weight, based on the total weight of the pigment. Processes for preparing the pigment also are provided.Type: ApplicationFiled: March 23, 2012Publication date: January 9, 2014Applicant: ECKART GMBHInventors: Michael Gruner, Thomas Schneider, Gunter Kaupp, Christian Rummer, Dirk Schumacher
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Publication number: 20140010880Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.Type: ApplicationFiled: June 26, 2013Publication date: January 9, 2014Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
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Publication number: 20140012271Abstract: Biomaterials, in particular bone foams, a process for preparing such materials as well as an applicator for applying the biomaterials directly to the patient's application site, and the use of a composition comprising water, a surfactant and a propellant in the preparation of a bone foam for the preparation of a calcium phosphate foam wherein the foam is obtainable by the mixture of at least two phases, a first phase comprising water and optionally a propellant, a second phase comprising one or more sources for calcium and/or phosphate, and wherein the foaming is performed during the mixture of the at least two phases to provide an improved calcium phosphate foam, process for the preparation of a calcium phosphate foam, use of a composition, solid state structure, calcium phosphate cement foam and bone foam applicator.Type: ApplicationFiled: November 10, 2010Publication date: January 9, 2014Applicant: STRYKER TRAUMA GMBHInventors: Hartwig Steckel, Maren Kuhli, Torben Christian Sörensen, Nils Reimers
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Publication number: 20140010766Abstract: The invention concerns multi-component packaged food products which have been thermally processed to achieve commercial sterility in a package, including at least a first component and a second component in contact with (eg immersed in) the first component, wherein said first component is comprised of a substantially water-based, liquid, pasty or gelled food such as sauce, gel, gravy, jus or the like, and wherein the second component consists of one or more relatively hard, manufactured pieces that substantially retain their initial shape and hard or crunchy textural functionality for at least an expected shelf-life of the product whilst exposed to the moisture content of the first component.Type: ApplicationFiled: January 12, 2011Publication date: January 9, 2014Applicant: MARS, INCORPORATEDInventors: Robert Sleigh, Brad William Woonton, Estelle Lifran, Tanoj Singh, Aung Htoon, Susan Finnegan
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Publication number: 20140005277Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.Type: ApplicationFiled: December 19, 2012Publication date: January 2, 2014Applicant: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Atsuko NAKATA, Eri MATSUMOTO
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Publication number: 20130331463Abstract: A method for producing a rutile titanium oxide sol having a particle diameter measured by dynamic light scattering of 5 nm to 100 nm, the method comprising: a process (a): mixing a tin oxalate aqueous solution, a titanium alkoxide, oxalic acid, a quaternary ammonium hydroxide, and water, while adjusting, per mole of titanium atoms, a proportion of tin atoms to be from 0.1 mol to 0.8 mol, a proportion of the oxalic acid to be from 0.01 mol to 5 mol, and a proportion of the quaternary ammonium hydroxide to be from 0.1 mol to 3.5 mol to prepare a titanium-containing aqueous solution having a concentration in terms of TiO2 of 0.1% by mass to 15% by mass; and a process (b): performing hydrothermal treatment on the titanium-containing aqueous solution produced in the process (a) at 100° C. to 200° C.Type: ApplicationFiled: February 15, 2012Publication date: December 12, 2013Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Natsumi Murakami, Ai Miyamoto, Yoshinari Koyama