Siliceous Or Calcareous Material (e.g., Clay, Earth, Etc.) Patents (Class 514/770)
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Publication number: 20110130291Abstract: A process for treating foliage by retaining an active agent in contact with the foliage is provided that includes the application of a biologically active ingredient carrier granule. The granule includes a mineral component, a cellulosic component, and a binder flowing upon wetting intermixed with the mineral component and the cellulosic components. A biologically active ingredient is added to the granule to treat the foliage. The foliage in either a dry or pre-wetted state. The contact of the granule with water causes the granule to flow to form a coherent film bound by the binder on the foliage with the active agent retained in the film in contact with the foliage.Type: ApplicationFiled: November 30, 2010Publication date: June 2, 2011Applicant: The Andersons, Inc.Inventors: Timothy D. Birthisel, Joe Schumski, IV
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Publication number: 20110123619Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients; (b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.Type: ApplicationFiled: February 4, 2011Publication date: May 26, 2011Applicant: OZPHARMA PTY. LTD.Inventors: Ernest Alan Hewitt, Richard James Stenlake
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Publication number: 20110117190Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: ApplicationFiled: November 7, 2008Publication date: May 19, 2011Inventors: Adrian Brown, Lee J. Gorringe, Stephen Mark McAllister, Wayne M. Matthews, Danielle Genevieve Rebecca Russell
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Patent number: 7939570Abstract: A controlled-release composition for topical application to a substrate includes an oil-in-water emulsion and an active agent incorporated into the oil-in-water emulsion. The oil-in-water emulsion is substantially free of lipophilic solvent and is formed by mechanical inversion of a water-in-oil emulsion. The water-in-oil emulsion includes a silicone component, a surfactant, and water. A method of delivering the active agent to the substrate provides the oil-in-water emulsion and incorporates the active agent into the oil-in-water emulsion for delivery of the active agent to the substrate upon application of the oil-in-water emulsion to the substrate.Type: GrantFiled: October 27, 2004Date of Patent: May 10, 2011Assignee: Dow Corning CorporationInventors: Victor A. Raul, Xavier Jean-Paul Thomas, Anne K. Shim, Gerald K. Schalau, II, Janelle L. Cabala
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Publication number: 20110104231Abstract: The invention provides a high performance porous bioceramic composite that has a high compression strength resulting from the ability to compression form a bioceramic precursor material and a pore forming agent under a high pressure load prior to sintering and/or removing the pore forming agent. Methods of making and using the same are also provided. Optionally, a biopolymer and/or therapeutic agent may be infused into the pores thereby forming the bioceramic composite.Type: ApplicationFiled: November 29, 2010Publication date: May 5, 2011Applicant: WARSAW ORTHOPEDIC, INC.Inventors: Ian Robert DUNKLEY, Reginald William SMITH
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Publication number: 20110104288Abstract: Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.Type: ApplicationFiled: November 2, 2010Publication date: May 5, 2011Applicant: FMC CORPORATIONInventors: Gregory Thoorens, Bruno LeClercq, Thomas Ruszkay
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Publication number: 20110091546Abstract: The present invention provides rapid disintegrating tablets in oral cavity having a shortened disintegration time in oral cavity as well as a sufficient hardness with compared to rapid disintegrating tablets of the prior art. The above objective is solved by a composition for rapid disintegrating tablets in oral cavity, wherein components (a) to (c) are contained in such manner that (a) saccharides consisting of a combination of mannitol and xylitol is 40 to 90 parts by weight; (b) the inorganic excipient is 1 to 30 parts by weight; and (c) the disintegrating agent is 5 to 40 parts by weight, provided that the total amount of (a), (b) and (c) is 100 parts by weight.Type: ApplicationFiled: October 20, 2010Publication date: April 21, 2011Applicant: FUJI CHEMICAL INDUSTRY CO., LTD.Inventors: Nobukazu TANAKA, Yoshiro Nagai, Hiroshi Kawaguchi, Tadashi Fukami, Terumasa Hosokawa
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Patent number: 7923030Abstract: Substantially leachless, agent-encapsulating sol-gel particles, methods of preparing same and products containing same are provided.Type: GrantFiled: March 11, 2004Date of Patent: April 12, 2011Assignee: Sol-Gel Technologies, Inc.Inventors: Noa Lapidot, Merav Blanca, Claudio Rottman, Oleg Naigertsik
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Publication number: 20110078920Abstract: A method of improving perspiration absorbency in a shoe or boot using particulate amorphous silica as an absorbent in insoles for shoes and/or boots, as well as a shoe insole containing an absorbent which contains particulate amorphous silica, and footware containing the insole.Type: ApplicationFiled: June 17, 2009Publication date: April 7, 2011Applicant: EVONIK DEGUSSA GmbHInventors: Juri Tschernjaew, Maya Krapfl, Patrick Stenner, Michael Beyer, Harald Haeger, Dirk Heinrich, Martina Gottheis
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Publication number: 20110081555Abstract: A stable, aqueous suspension concentrate which includes a solid polymeric dispersant comprising one or more anionic polymeric dispersing agents, optionally a co-dispersant which preferably is a homopolymer and/or a copolymer of a heterocyclic vinyl lactam, preferably in a wt. ratio of 0.1:1 to 1:0.1, a UV-labile, water-insoluble biocide active, and a UV-blocker or UV-absorber to stabilize said active upon storage and/or exposure to sunlight or UV radiation.Type: ApplicationFiled: December 13, 2010Publication date: April 7, 2011Applicant: ISP INVESTMENTS INC.Inventors: Xianbin Liu, Karen Winkowski, Kolazi S. Narayanan, Jean-Jacques Gulka
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Publication number: 20110060020Abstract: A process for the release of a biologically active species comprising the steps of: providing a mesoporous oxide-based material having structural order and at least one level of porosity; fixing or immobilizing said biologically active species in said ordered mesoporous oxide; and providing said ordered mesoporous oxide with said fixed or immobilized biologically active species in vivo thereby realizing intraluminally induced substantially pH-independent supersaturation of said biologically active species resulting in enhanced transepithelial transport; wherein said biologically active species is a poorly soluble therapeutic drug classified as belonging to Class II or Class IV of the Biopharmaceutical Classification System and said ordered mesoporous oxide has a pore size in the range of 4 to 14 nm.Type: ApplicationFiled: January 28, 2009Publication date: March 10, 2011Applicant: Katholieke Universiteit Leuven K.U. Leuven R&DInventors: Patrick AUGUSTIJNS, Johan Adriaan Martens, Randy Mellaerts, Guy Van Den Mooter
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Publication number: 20110052659Abstract: A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-errordable doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached.Type: ApplicationFiled: June 28, 2010Publication date: March 3, 2011Applicant: PSIMEDICA LIMITEDInventors: Leigh T Canham, Christopher P Barrett, Timothy I Cox, Peter J Wright, Andrew P Bowditch
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Publication number: 20110046240Abstract: The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers.Type: ApplicationFiled: August 24, 2009Publication date: February 24, 2011Inventors: Timothy S. Keizer, Brett M. Showalter, Bruce A. Keiser, James H. Adair
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Publication number: 20110046241Abstract: The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers.Type: ApplicationFiled: August 24, 2009Publication date: February 24, 2011Inventors: Timothy S. Keizer, Brett M. Showalter, Bruce A. Keiser, James H. Adair
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Publication number: 20110046238Abstract: The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers.Type: ApplicationFiled: August 24, 2009Publication date: February 24, 2011Inventors: Bruce A. Keiser, Timothy S. Keizer, Brett M. Showalter, Tiffany Bohnsack, James H. Adair, Mylisa Parette, Amy Knupp, Andrei S. Zelenev, Jason R. Burney
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Publication number: 20110046239Abstract: The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers.Type: ApplicationFiled: August 24, 2009Publication date: February 24, 2011Inventors: Bruce A. Keiser, Timothy S. Keizer, Brett M. Showalter, Tiffany Bohnsack, James H. Adair, Mylisa Parette, Amy Knupp, Andrei S. Zelenev, Jason R. Burney
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Publication number: 20110038938Abstract: The embodiments set forth herein provide biocompatible self-setting compositions suitable for use in tissue augmentation applications. The biocompatible self-setting compositions described herein exhibit advantageous theological properties and may be applied to a site in the body of a patient by injecting the composition through a 20-30 gauge needle. Once applied to a site in the body, the composition sets to a slow resorbing or substantially non-resorbing matrix. Advantageously, exposure of the composition material to body heat at its site of use enhances setting of the composition.Type: ApplicationFiled: August 18, 2010Publication date: February 17, 2011Inventors: Ira C. Ison, Brooke Campbell
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Patent number: 7879346Abstract: The present invention provides a cosmetic composition including oil phase ingredients 40-90% by weight and powder ingredients 10-60% by weight. The oil phase ingredients include volatile oil 5-70 parts by weight and dimethicone/vinyl-dimethicone crosspolymer 0.1-5 parts by weight. The powder ingredients include organic hectorite 0.5-40 parts by weight, methyl methacrylate crosspolymer 0.5-5 parts by weight, and pulverulent body 0.5-50 parts by weight.Type: GrantFiled: August 9, 2006Date of Patent: February 1, 2011Assignee: STC Nara Co., Ltd.Inventors: Kye-Ho Lee, Jong-Hwan Kim, Sung-Ho Chung
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Publication number: 20100331187Abstract: The present invention relates to physically stable oil dispersions. It also relates to a method for activating bentones that are designed for use with a low polarity organic systems. It also relates to physically stable oil dispersions comprising said activated bentone.Type: ApplicationFiled: June 9, 2008Publication date: December 30, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Kirsty Jane Williams, Johathan Mark Richards
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Patent number: 7858656Abstract: A controlled release melatonin tablet having a slow release nucleus of melatonin, hydroxypropyl methylcellulose, a lubricant, a volume excipient and a glidant, wherein 95% of the melatonin is released within 5 hours in an oscillating tray containing gastric/intestinal juice at 37° C. and a fast release cortex coating on said nucleus of melatonin, hydroxypropyl methylcellulose and a volume excipient, wherein at least 95% of the melatonin is released within 10 minutes in an oscillating tray containing gastric/intestinal juice at 37° C.Type: GrantFiled: November 13, 2007Date of Patent: December 28, 2010Assignee: Ambros Pharma S.R.L.Inventor: Bojidar M. Stankov
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Patent number: 7858123Abstract: The invention provides compositions, methods and devices relating to a silaceous oxide that generates a reduced heat of hydration upon contact with blood. By reducing the heat of hydration, the compositions provide a hemostatic agent that attenuates a tissue burning side effect of conventional hemostatic agents without adversely affecting the wound healing properties of the composition.Type: GrantFiled: April 4, 2006Date of Patent: December 28, 2010Assignee: The Regents of the University of CaliforniaInventors: Galen D. Stucky, Todd A. Ostomel, Qihui Shi, Peter K. Stoimenov, Patricia A. Holden
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Publication number: 20100323023Abstract: The present invention relates to a composition for use in the treatment of a detached retina, comprising a dispersion of nanoparticles in a liquid, wherein the nanoparticles have a specific gravity which is higher than that of the liquid and the individual refractive indices of the nanoparticles and the liquid are substantially similar to one another. The present invention also relates to a composition for use in the treatment of a detached retina, comprising a dispersion of silica nanoparticles in a liquid, a method and kit of parts for producing the compositions and a method of treating a detached retina.Type: ApplicationFiled: December 3, 2008Publication date: December 23, 2010Applicant: ULIVE ENTERPRISES LIMITEDInventors: Michael Garvey, Rachel Lucinda Williams, David Sai Hung Wong
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Publication number: 20100322902Abstract: Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound.Type: ApplicationFiled: September 2, 2010Publication date: December 23, 2010Inventors: Yutaka Mizushima, Yasuaki Ogawa, Junzo Tanaka, Toshiyuki Ikoma
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Publication number: 20100310617Abstract: The present invention relates to a water-in-oil system, which comprises 1.5-9 wt. % of hydrophobic silica, 0.1-5 wt. % of a water-in-oil emulsifier, 10-40 wt. % of an oil phase, with the content of the oil phase not including the hydrophobic silica and water-in-oil emulsifier therein, and 55-85 wt % of a water phase; with the proviso that said hydrophobic silica is not AEROSIL® RY200 hydrophobic fumed silica, and it is excluded the formulation comprising the components of: polyoxyalkylene modified polysiloxane SH3775E, a compound of the following formula (I) and hydrophobic fumed silica AEROSIL® R812, in which the weight ratio of SH3775E to the compound of formula (I) is 05, and the weight ratio of the sum of SH3775E and the compound of formula (I) to hydrophobic fumed silica AEROSIL® R812 is also 05.Type: ApplicationFiled: June 3, 2010Publication date: December 9, 2010Applicant: EVONIK GOLDSCHMIDT GMBHInventors: Haizhou Zhang, Jiali Zou, Jingya Dai, Zhiheng Gao
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Publication number: 20100304974Abstract: The present composition is capable of forming a particle film and comprises: (a) less than 99.65% by weight of at least one particle; (b) at least one volumizing agent selected from the group consisting of: (i) cellulose selected from the group consisting of ethyl hydroxy ethyl cellulose, hydroxy ethyl cellulose, hydroxy propyl cellulose, hydroxy ethyl methyl cellulose, hydroxy propyl methyl cellulose, methyl cellulose, ethyl cellulose, and ethyl methyl cellulose and present in an amount greater than 0.35% by weight; and (ii) non-cellulosic component or cellulose other than said cellulose (i) present in an amount of at least 0.05% by weight; and optionally (c) at least one spreader. The composition may be used to form agricultural films.Type: ApplicationFiled: August 6, 2010Publication date: December 2, 2010Inventors: John T. Mosko, Richard C. Pluta, David Michael Glenn, Gary Puterka
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Publication number: 20100297045Abstract: The invention relates to effect pigments comprising artificial platelet-shaped substrates which have at least one optically active coating, where the effect pigments have a volume-averaged cumulative undersize distribution curve with the characteristic numbers D10, D50 and D90, said cumulative undersize distribution curve having a span ?D of 0.7-1.4, and the span ?D being calculated in accordance with formula (I): ?D=(D90?D10)/D50??(I), and the average thickness of the artificial platelet-shaped substrates being 500 nm to 2000 nm.Type: ApplicationFiled: November 25, 2008Publication date: November 25, 2010Inventors: Günter Kaupp, Ulrich Schmidt, Dirk Schumacher, Ralph Schneider
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Publication number: 20100297232Abstract: The present invention relates to products and methods of making products having a taste masked active component. In particular, the present invention relates to taste-masked film dosage forms including at least one active component and a slow dissolving basic composition.Type: ApplicationFiled: May 19, 2009Publication date: November 25, 2010Applicant: MonoSol Rx, LLCInventors: Garry L. Myers, Madhusudan Hariharan, Pradeep Sanghvi
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Publication number: 20100288795Abstract: Dispersion comprising hydrophobic pyrogenically prepared silicon dioxide, alcohol and at least one additive which promotes the dispersion and, as additional component, at least one insecticide and/or acaricide. The dispersion can be canned in spray cans and used as insecticide.Type: ApplicationFiled: December 30, 2008Publication date: November 18, 2010Applicant: EVONIK DEGUSSA GmbHInventors: Wolfgang Lortz, Jochen Scheffler, Gabriele Perlet
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Publication number: 20100285164Abstract: The present invention is directed to coprocessed excipient particles comprising a cellulosic material such as microcrystalline cellulose in intimate association with silicon dioxide, a disintegrant and a polyol, sugar or a polyol/sugar blend. The excipient particles display good processing and are useful in prepared compressed solid dosage forms that exhibit rapid disintegration (less than about 60 seconds) when placed on the tongue or when tested according to USP disintegration testing, while still providing acceptable mouth feel.Type: ApplicationFiled: May 11, 2009Publication date: November 11, 2010Applicant: JRS PharmaInventors: David Schaible, Louis Mejias
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Publication number: 20100286286Abstract: The invention provides an orally disintegrating tablet that has both adequate tablet hardness and rapid disintegrability in the oral cavity, and that undergoes minor hardness reduction and maintains good oral disintegrability even when preserved under moist conditions. In particular, the invention relates to an orally disintegrating tablet containing (a) crystalline cellulose, (b) a calcium hydrogen phosphate compound, (c) a natural starch and (d) a lubricant, wherein the blending ratio to 100 wt % of the disintegrating tablet is (a) 9 to 60 wt %, (b) 16 to 60 wt %, (c) 3 to 40 wt % and (d) 0.01 to 1.8 wt %.Type: ApplicationFiled: November 21, 2008Publication date: November 11, 2010Applicant: DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Yuki Ikeda, Yasushi Ochiai
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Publication number: 20100266648Abstract: Compositions and methods are disclosed for imparting super-hydrophobic properties to cosmetics, which can be used to significantly improve water repellency compared to traditional cosmetics. The compositions comprise a hydrophobic film former, and hydrophobic particles, in an emulsion base.Type: ApplicationFiled: November 14, 2008Publication date: October 21, 2010Applicant: AVON PRODUCTS, INC.Inventors: Rahul A. Ranade, John R. Glynn, Mark S. Garrison, Shari Martin, Prithwiraj Maitra
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Patent number: 7807151Abstract: The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid-producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds.Type: GrantFiled: April 23, 2008Date of Patent: October 5, 2010Assignee: Ganeden Biotech, IncorporatedInventor: Sean Farmer
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Publication number: 20100226964Abstract: The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.Type: ApplicationFiled: March 9, 2010Publication date: September 9, 2010Applicant: SPI Pharma, Inc.Inventors: John Tillotson, Cecil Propst
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Publication number: 20100226999Abstract: The present invention relates to a method for forming an ophthalmic composition comprising mixing at least one hydroxide and pentetic acid with water and at least one oxidatively unstable component to form an ophthalmic composition comprising at least one salt of diethylenetriamine pentaacetic acid and a pH between about 6 and about 8.Type: ApplicationFiled: March 6, 2009Publication date: September 9, 2010Inventor: Tracy Quevillon-Coleman
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Publication number: 20100215705Abstract: One aspect of the invention is a method of controlling target living species with an active ingredient over an extended period of time. This method sorbs an active ingredient into colloidal clay. Next, a polymer pellet recalcitrant to release of the active ingredient is loaded with the sorbed colloidal clay. Finally, the loaded polymer pellet is formed into a barrier, which is adapted to be placed at a location for controlling a target living species. Another aspect is a barrier for controlling a target living species. The formed barrier contains polymer pellets loaded with colloidal clay sorbed with an active ingredient that controls the target living species. The sorbed clay loaded polymer pellets are recalcitrant to release of the active ingredient.Type: ApplicationFiled: March 29, 2010Publication date: August 26, 2010Applicant: BIOGUARD RESEARCH AND DEVELOPMENT, INC.Inventors: Dominic A. Cataldo, Edward S. Lipinsky, Peter VanVoris
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Publication number: 20100215703Abstract: To provide a vesicle-containing composition wherein the stability is improved and the rate of releasing drug or perfume is sufficiently restricted during administration in vivo or application to the skin surface. Silica polymerization on the outer surfaces of vesicles is facilitated by adding a specifically structured water-soluble silane derivative to an aqueous composition containing the vesicles composed of a surfactant and mixing them together, and vesicle-silica composites having silica-coated outer surfaces can be obtained, resulting in the improved stability of the vesicle-containing composition as well as the improved effect of restricting the rate of releasing drug or perfume during administration in vivo or application to the skin surface.Type: ApplicationFiled: August 27, 2008Publication date: August 26, 2010Applicant: SHISEIDO COMPANY LTD.Inventors: Kei Watanabe, Yuko Nagare
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Publication number: 20100210736Abstract: The present invention provides a method for stabilizing fine particles of calcium phosphates without lowering their solid phase forming activity. It is possible to stabilize the fine particles of calcium phosphates by stopping the growth of the fine particles formed in an aqueous solution supersaturated with respect to calcium phosphates. More specifically, the fine particles of calcium phosphates were stabilized by lowering the inorganic ion concentration of a fine-particle-forming solution containing fine particles of calcium phosphates by dialysis, ion exchange, dilution, or the like, or by separating the fine particles of calcium phosphates from the fine-particle-forming solution by filtration, centrifuging, or the like.Type: ApplicationFiled: August 15, 2006Publication date: August 19, 2010Inventors: Takeshi Yao, Mitsuhiro Hibino, Seiji Yamaguchi, Hidetaka Okada
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Publication number: 20100204342Abstract: The present invention is to provide hollow particles with a low degree of agglomeration and having a high roundness, and a process for producing them. Hollow particles comprising a silicon compound, having an average particle size of from 5 to 65 nm and an average roundness of at least 0.90, and having a shell comprising the silicon compound and having a thickness of from 1 to 20 nm. Further, a method for producing hollow particles, which comprises adding sulfuric acid to a liquid containing spherical organic polymer-silicon compound composite particles having a core comprising an organic polymer and a shell comprising a silicon compound in a medium containing at least 95 mass % of water, followed by heating to carbonize the organic polymer thereby to convert it to a carbide, and subjecting the carbide to decomposition using a liquid oxidizing agent other than sulfuric acid.Type: ApplicationFiled: June 26, 2008Publication date: August 12, 2010Applicant: Denki Kagaku Kogyo Kabushiki KaishaInventors: Takashi Kawasaki, Motoharu Fukazawa, Isao Sugimoto
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Publication number: 20100204341Abstract: Personal care dissolvable films comprising a water soluble film forming agent, cosmetically acceptable plasticizer, and a thickener are described, along with methods of using the same.Type: ApplicationFiled: June 26, 2008Publication date: August 12, 2010Inventors: Wei Hong Yu, Tatiana V. Drovetskaya, Susan L. Jordan
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Publication number: 20100196435Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.Type: ApplicationFiled: July 9, 2008Publication date: August 5, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: William R. Freeman, Michael J. Sailor, Lignyun Cheng
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Patent number: 7749537Abstract: A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.Type: GrantFiled: October 1, 2007Date of Patent: July 6, 2010Assignee: SCOLR Pharma, Inc.Inventors: Michael Hite, Cathy Federici, Alan Brunelle, Stephen Turner
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Publication number: 20100150973Abstract: The present invention relates to a granule for use in formulations of personal care and/or home care products having liquid to creamy (or pasty) consistency, the granule or granules being specially suitable for use as visual agents, delivery systems, exfoliating and/or abrasive agents in these products. The object of the present invention is to provide granules consisting of clay or clay and starch, which maintain their physical integrity in formulations of personal care and/or home care products with liquid to creamy (or pasty) consistency. This object is achieved by a granule consisting of the combination of clay and starch, wherein at least one portion of clay is thermally treated, with modification of the crystalline structure of at least one fraction of the treated clay. The object is also achieved by a granule consisting of clay, wherein at least one portion of the clay is thermally treated, with alteration of the crystalline structure of at least one fraction of the clay.Type: ApplicationFiled: March 20, 2007Publication date: June 17, 2010Inventor: Patricia Moura Dias
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Publication number: 20100151047Abstract: Disclosed are yellowing-stable, silver-white effect pigments having high whiteness based on synthetic mica flakes and to the use thereof in paints, lacquers, printing inks, plastics, button pastes, ceramic materials, glasses, for coloring seed, as dopant in laser markings of plastics and papers, as additive for laser welding of plastics, as additive for coloring in the foods and pharmaceuticals sectors and in cosmetic formulations, and for the preparation of pigment compositions and dry preparations.Type: ApplicationFiled: February 17, 2010Publication date: June 17, 2010Inventors: Gerhard PFAFF, Johann Dietz, Sabine Schoen, Doreen Warthe
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Publication number: 20100144896Abstract: The present invention relates to a thixotropic pharmaceutical composition in which the viscosity is changed due to external mechanical stress applied so that isothermal and continuous gel/sol/gel transition occurs. The thixotropic pharmaceutical composition includes a pharmacologically active substance, a biocompatible thickener having a predetermined thixotropic property, and optionally a hydrophilic thickener. The viscosity of the composition is relatively rapidly changed within a predetermined range. Accordingly, it is easy to measure the amount of drugs to be administered, it is possible to administer a precise amount of drugs to a patient, the compliance of a patient with dosage of drugs is high, and it is easy to produce the composition.Type: ApplicationFiled: February 4, 2008Publication date: June 10, 2010Inventors: Mikyoung Hahn, Se-Hyun Song, Hee-Jeong Lim, Jin-Woo Choi, Hyeon Kuk
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Publication number: 20100143481Abstract: Pharmaceutical formulations comprising a multi-phasic pharmaceutical composition, and an adsorbent carrier, where the pharmaceutical formulation is a solid dosage form. Methods for preparing such pharmaceutical compositions are described.Type: ApplicationFiled: November 8, 2007Publication date: June 10, 2010Inventors: Dinesh Shenoy, Robert Lee, Kumaresh Soppimath, Guru Betageri
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Publication number: 20100136117Abstract: The invention pertains to a biocompatible composition, suitable for use in soft or hard tissue augmentation, wherein the composition is an aqueous suspension containing a carrier fraction of ceramic particles of less than 15 &mgr;m and an augmentation fraction of ceramic particles of at least 20 &mgr;m. The ceramics typically comprise calcium phosphate. The composition is a may be used in soft tissue repair as well as hard bone replacement. It advantageously avoids the need for foreign body materials which are conventionally applied to stabilize augmentation suspensions.Type: ApplicationFiled: October 4, 2007Publication date: June 3, 2010Inventor: Klaas DE GROOT
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Patent number: 7722891Abstract: Storage stable multiple emulsions of a polar phase A1, a nonpolar phase B and a polar phase A2, or of a nonpolar phase B1, a polar phase A and a nonpolar phase B2, employ particulate solids smaller than 1 ?m to stabilize the resulting A1/B/A2 or B1/A/B2 multiple emulsions against coalescence, with the proviso that surface-active substances are present only up to a maximum concentration of less than 0.1 times the critical micelle concentration of the surface-active substances in phase A, A1, A2. The multiple emulsions have numerous uses including controlled release of active substances from a dispersed phase.Type: GrantFiled: February 28, 2003Date of Patent: May 25, 2010Assignee: Wacker Chemie AGInventors: Herbert Barthel, Bernard Paul Binks, Amro Dyab, Paul Fletcher
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Patent number: 7718184Abstract: Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care formulations and suspensions are provided. Uncoated calcium silicate exhibits a high pH level that may have a deleterious effect upon such cosmetic and/or personal care compositions, thereby rendering the overall composition ineffective for its intended purpose, particularly if the calcium silicate is present in its usual state at high loading levels. Alternatively, if certain materials present within personal care compositions exhibit a sufficiently low pH level, the effectiveness of such calcium silicates may be compromised as well.Type: GrantFiled: June 26, 2007Date of Patent: May 18, 2010Assignee: J.M. Huber CorporationInventors: Michael C. Withiam, Donald P. Conley, Michael Simone
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Publication number: 20100120723Abstract: The present invention relates to a lubricant granulate prepared using a hot melt granulation process, or thermal-heat process. The lubricant granulate is useful in facilitating the use of higher concentrations of lubricant than typically possible in pharmaceutical compositions. Also provided are pharmaceutical compositions comprising the lubricant granulate. Such pharmaceutical compositions can contain bisphosphonic acid as the active ingredient and can be suitable for oral administration. The present invention also provides a hot melt process for preparing the lubricant granulate for subsequent use in pharmaceutical compositions.Type: ApplicationFiled: December 19, 2007Publication date: May 13, 2010Inventors: Mostafa Akbarieh, Thinesh Sivarajah, Shetal Shah
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Publication number: 20100112015Abstract: With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.Type: ApplicationFiled: November 30, 2009Publication date: May 6, 2010Applicant: LINTEC CORPORATIONInventor: Eiji Nogami