Siliceous Or Calcareous Material (e.g., Clay, Earth, Etc.) Patents (Class 514/770)
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Patent number: 6635281Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.Type: GrantFiled: December 22, 1999Date of Patent: October 21, 2003Assignee: Alza CorporationInventors: Patrick S.-L. Wong, David E. Edgren
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Patent number: 6632805Abstract: A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article.Type: GrantFiled: May 7, 1996Date of Patent: October 14, 2003Assignee: Emory UniversityInventors: Lanny S. Liebeskind, Gary D. Allred
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Patent number: 6627224Abstract: Compositions containing a low dose of entecavir are administered on a daily basis to treat hepatitis B virus infection and/or co-infections. Formulations for the oral administration of a low dose of entecavir are provided. Other pharmaceutically active substances can be included in the entecavir composition or can be separately administered for the treatment of hepatitis B virus infection or for the treatment of co-infected patients.Type: GrantFiled: February 23, 2001Date of Patent: September 30, 2003Assignee: Bristol-Myers Squibb Co.Inventors: Richard J. Colonno, Omar L. Sprockel, Abizer Harianawala, Divyakant Desai, Michael G. Fakes
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Publication number: 20030180376Abstract: A porous &bgr;-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 &mgr;m, preferably 50-125 &mgr;m. The porous &bgr;-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous &bgr;-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous &bgr;-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous &bgr;-TCP material and inducing bone formation are also provided.Type: ApplicationFiled: September 21, 2001Publication date: September 25, 2003Inventors: Paresh S. Dalal, Godofredo R. Dimaano, Carol Ann Toth, Shailesh C. Kulkarni
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Patent number: 6620432Abstract: A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier.Type: GrantFiled: May 11, 2001Date of Patent: September 16, 2003Assignee: Mylan Pharmaceuticals Inc.Inventors: William J. Addicks, Joseph P. Duda, Daniel A. Snider, Kerry R. Benson
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Patent number: 6617356Abstract: Suspensions, emulsions or dispersions of therapeutically active agents which are water insoluble or water intolerant such as nutritional supplements, herbal products, drugs, bacteria, yeast, vitamins and minerals are prepared as suspensions in edible vegetable oils such as orange, lemon, soybean, cotton seed, peanut, canola corn oil, sunflower, safflower, palm kernel, palm and coconut. The active therapeutic agent may be in crystalline or amorphous form, it may be a liquid as for example an oil such as vitamin B or beta carotene, or a preparation of a comminuted plant structure such as flower, parts, leaf; stern, root or tree bark, or an extract of a dried plant structure or a freeze dried preparation of a vital bacteria or yeast. The suspension is formed by active mixing of the active agent and oil.Type: GrantFiled: January 3, 2000Date of Patent: September 9, 2003Inventors: Louis P. Goodman, Dennis Bizub
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Patent number: 6610673Abstract: A swallowable, solid dose form composition for treating upper gastrointestinal tract distress containing bismuth subsalicylate, carbonate or bicarbonate salt, disintegrating agent, anionic or nonionic surfactant, and microcrystalline cellulose is described.Type: GrantFiled: May 12, 1999Date of Patent: August 26, 2003Assignee: The Procter & Gamble CompanyInventors: Francis Bernard Chapura, Daniel Louis Barone, Michael Gerard Colacino
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Patent number: 6596300Abstract: The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in ruminant animals. The method includes mixing ingredients that include 190 proof ethanol in a concentration of about 9% by weight of a food supplement with clay and a nitrogen source such as urea to form the food supplement. The food supplement for ruminant animals additionally includes a condensed distiller's soluble fraction. The mixed ingredients are added to an animal feed such as corn. The animal feed and supplement are fed to an animal at least one per day.Type: GrantFiled: November 16, 1999Date of Patent: July 22, 2003Inventor: Ben Steensma
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Patent number: 6576633Abstract: Anhydrous, liquid antimicrobial compositions comprising quaternaries 1-(benzyl)-3,5,7-triaza-1-azoniaadamantane chloride, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride and the cis- and cis/trans-isomers thereof, 1-(&agr;-(2-xylyl))-3,5,7-triaza-1-azoniaadamantane chloride and methyl 1-(3,5,7-triaza-1-azoniaadamantane chloride) acetate in admixture with an anhydrous carrier liquid and a thixotropic material are substantially stable to color changes, physical changes and/or chemical changes while under conventional storage conditions for extended time periods.Type: GrantFiled: February 22, 1996Date of Patent: June 10, 2003Assignee: The Dow Chemical CompanyInventors: Tracy L. Young, Philip J. Brondsema
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Patent number: 6569440Abstract: The present invention provides an emitter of semiochemical substances that comprising a support and a semiochemical subsistence adsorbed in the same, is characterized in that said support is a sepiolite and in that the retaining force between said sepiolite and said semiochemical substance is regulated in such a way that a controlled emission kinetics of said semiochemical substance is obtained. The process for the manufacture of said emitter comprises the operations of modifying a natural sepiolite and of associating it to a semiochemical substance, in such a way that the same is retained with a force such that the emitter has a controlled release kinetics of the substance. The cited emitter is especially useful in the agricultural sector, for insect plague control in crops.Type: GrantFiled: March 6, 2000Date of Patent: May 27, 2003Assignees: Consejo Superior De Investigaciones Cientificas, Universidad Politecnica De ValenciaInventors: Avelino Corma Canos, Juan Muñoz Pallares, Eduardo Primo Yufera
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Patent number: 6569407Abstract: The invention relates to hair compositions comprising, in a cosmetically acceptable medium, a polycondensate comprising at least one polyurethane and/or polyurea unit and a silicone comprising at least one carboxylic function. The invention is also directed towards a process for shaping or maintaining the hairstyle, comprising the use of these compositions, and to their use for the manufacture of hair products, in order to maintain or shape the hairstyle.Type: GrantFiled: August 27, 1999Date of Patent: May 27, 2003Assignee: L'Oreal S.A.Inventors: Jean-Michel Sturla, Jean-Luc Bremenson
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Patent number: 6544558Abstract: Syrup formulations comprising water and compacted granulates which are mixture of amoxycillin and clavulanic acid, together with an intra-granular disintegrant.Type: GrantFiled: November 19, 2001Date of Patent: April 8, 2003Assignee: Labratorios Beecham SAInventors: Luis Carvajal Martin, Juan Dedios Romero
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Patent number: 6531142Abstract: Disclosed are stabilized electrostatically-sprayable topical compositions and methods of treating the skin by electrostatic application of such compositions. The compositions comprise: a) from about 2% to about 90% of a liquid insulating material; b) from about 2% to about 90% of a conductive material; c) from about 0.1% to about 35% of a particulate material which is insoluble and immiscible in the composition; and d) from about 0.5% to about 30% of a thickener for stabilizing the composition. The liquid insulating materials and conductive materials present in the composition are sufficiently miscible or soluble in the composition such that they are in substantially one phase.Type: GrantFiled: July 31, 2000Date of Patent: March 11, 2003Assignee: The Procter & Gamble CompanyInventors: Thomas Elliot Rabe, Helen Shu Ying Yen, Spiros Aristotle Nicols
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Patent number: 6524618Abstract: An extended-release matrx formulation capable of being directly compressed into tablets comprising metformin hydrochloride blended with specific excipients. The excipients used in the formulation enhance the flow and compaction properties of the drug and insure that the formulation is directly compressible into a tablet containing about 100 mg to about 800 mg, preferably about 250 mg to about 750 mg, of metformin hydrochloride in unit dosage form. Each tablet produced by direct compression of the formulaton has the desired hardness and dissolution characteristics such that the drug is released in the body of the subject over an extended period of time.Type: GrantFiled: June 12, 2001Date of Patent: February 25, 2003Inventors: Vijai Kumar, Kevin Scott McGuffy
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Patent number: 6511657Abstract: A two-phase roll-on antiperspirant and/or deodorant is described which comprises: (a) a clear, translucent or opaque non-polar phase having a viscosity in the range of 20 cps-9,000 made by combining: a cross-linked or partially cross-linked non-emulsifying siloxane elastomer; 0.1-70 weight % of one or more low viscosity, lipophilic emollients; (b) a clear, translucent or opaque polar phase have a viscosity in the range of 20-9,000 cps made by combining: one or more members selected from the group consisting of water, glycols and polyhydric alcohols; and an antiperspirant active salt which is soluble or suspendible in the polar phase; wherein the polar phase comprises (i) a sufficient amount of water, glycols or polyhydric alcohols to dissolve or suspend the antiperspirant active, and (ii) optionally may comprise up to 30 weight % water; up to 16.00 weight % of ethyl alcohol; up to 16 weight % isopropyl alcohol; or mixtures of the foregoing; (iii) 0.1-2.Type: GrantFiled: April 20, 2001Date of Patent: January 28, 2003Assignees: Colgate-Palmolive Company, Dow Corning CorporationInventors: Esther Avendano, Adriana Urrutia-Gutierrez, Wilson Lee, Xiaozhong Tang
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Patent number: 6509036Abstract: The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.Type: GrantFiled: October 29, 2001Date of Patent: January 21, 2003Assignee: Cima Labs Inc.Inventors: S. Indiran Pather, Joseph R. Robinson, Jonathan D. Eichman, Rajendra K. Khankari, John Hontz, Sangeeta V. Gupte
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Patent number: 6503519Abstract: A dermatic cosmetic material containing as a substrate a silicone composition paste comprising (i) a cross-linked silicone polymer having hydrophilic polyoxyalkylene groups wherein polyoxyethylene moieties are comprised, which functions as a thickener component, and (ii) a silicone oil, thereby enabling stable incorporation of an antiperspirant or water-soluble vitamins and further ensuring improvements in usability.Type: GrantFiled: June 23, 2000Date of Patent: January 7, 2003Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Koji Sakuta
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Patent number: 6500459Abstract: A pharmaceutical composition for controlled onset and sustained release of an active ingredient, said composition comprising: (i) a core comprising: (a) an active ingredient; (b) a hydrophilic carrier; (c) a hydrodynamic diffusion enhancer; and optionally (d) conventional pharmaceutically acceptable excipients selected from the group consisting of binders, fillers and lubricants and combinations thereof; and (ii) a functional coating membrane surrounding said core.Type: GrantFiled: July 21, 1999Date of Patent: December 31, 2002Inventors: Harinderpal Chhabra, Shyamal K. Sarkar
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Aerosol device containing a polycondensate comprising at least one polyurethane and/or polyurea unit
Patent number: 6495119Abstract: The invention relates to aerosol devices comprising a container which contains, in a cosmetically acceptable medium, a multiblock polymer comprising at least one polyurethane and/or polyurea unit, these devices being suitable for obtaining an initial flow rate of aerosol composition of less than or equal to 0.75 gram per second. The invention is also directed towards a process for shaping or maintaining the hairstyle, comprising the use of these devices, as well as their use for the manufacture of a lacquer or an aerosol spray.Type: GrantFiled: August 27, 1999Date of Patent: December 17, 2002Assignee: L'Oreal S.A.Inventors: Jean-Michel Sturla, Jean-Luc Bremenson, François Le Bourhis, Arnaud Vilbert -
Patent number: 6495163Abstract: A dry moisture barrier film coating composition for forming a moisture barrier film coating for pharmaceutical tablets and the like comprises polyvinyl alcohol, soya lecithin, and optionally a flow aid, a colorant, and/or a suspending agent. A liquid coating solution or dispersion for forming a moisture barrier film coating for pharmaceutical tablets and the like comprises polyvinyl alcohol, soya lecithin, water, and optionally a flow aid, a colorant, and/or a suspending agent. A method of coating pharmaceutical tablets and the like with a moisture barrier film coating comprises forming a liquid coating solution or dispersion for forming a moisture barrier film coating for pharmaceutical tablets and the like comprising polyvinyl alcohol, soya lecithin, water, and optionally a flow aid, a colorant, and/or a suspending agent, applying the coating solution or dispersion onto the tablets to form a film coating on the tablets, and drying the film coating on the tablets.Type: GrantFiled: September 23, 1998Date of Patent: December 17, 2002Assignee: BPSI Holdings, Inc.Inventor: Martin Philip Jordan
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Publication number: 20020168596Abstract: The present invention relates to a composite material with an improved structure in which is dispersed an active organic compound, and a method for treating effluents, in particular a method for treating photographic effluents.Type: ApplicationFiled: February 5, 2002Publication date: November 14, 2002Applicant: Eastman Kodak CompanyInventors: Olivier J. Poncelet, Danielle M. Wettling
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Patent number: 6479040Abstract: The present invention includes a cosmetic formulation. The cosmetic formulation comprises a plurality of spheres having a first desiccated volume and having a second hydrated volume. The hydrated volume is greater than the desiccated volume.Type: GrantFiled: February 6, 2001Date of Patent: November 12, 2002Assignee: Coty Inc.Inventors: Salvatore Barone, Antonietta Corrigan, Mita Mody, Melizza Bautista, Ralph Macchio, Louis Veltry
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Patent number: 6479075Abstract: This invention in general relates to novel pharmaceutical compositions for acid labile substances as well as for methods of making such. Specifically, the invention provides a pharmaceutical composition comprising about 1 to 75% by weight acid labile compound, up to about 5% by weight disintegrant, at least one protector coat layer used to separate and protect the acid labile substance from acid reacting groups and gastric juice, and at least one enteric coat layer which surrounds the protector coating layer and ensures delivery of over 80% the acid labile substance to the small intestine.Type: GrantFiled: January 22, 2001Date of Patent: November 12, 2002Inventors: Isa Odidi, Amina Odidi
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Patent number: 6475496Abstract: An organic solvent based cosmetic remover composition gelled to a viscosity of 25 to 500,000 centipoise with a synthetic metal silicate gelling agent.Type: GrantFiled: August 17, 2000Date of Patent: November 5, 2002Assignee: Revlon Consumer Products CorporationInventors: Scott Arnold Arminas, Joseph Frank Calello
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Patent number: 6468964Abstract: According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the gastrointestinal tract of a human or an animal, said accumulation resulting from the fermentation of carbohydrate in the gastrointestinal tract of said human or animal, wherein said method comprises administering to said human or animal an effective amount of an active agent capable of preventing or controlling acid and endotoxin accumulation in the gastrointestinal tract.Type: GrantFiled: July 25, 2001Date of Patent: October 22, 2002Assignee: University of New England, of ArmidaleInventor: James Baber Rowe
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Patent number: 6468657Abstract: Multilayered porous materials are formed by coating a porous substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel porous materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis and the like.Type: GrantFiled: December 4, 1998Date of Patent: October 22, 2002Assignee: The Regents of the University of CaliforniaInventors: Zhizhong Hou, Pieter Stroeve, Nicholas Abbott
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Patent number: 6461607Abstract: The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid-producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds.Type: GrantFiled: August 5, 1999Date of Patent: October 8, 2002Assignee: Ganeden Biotech, Inc.Inventor: Sean Farmer
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Patent number: 6458763Abstract: The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.Type: GrantFiled: September 17, 1999Date of Patent: October 1, 2002Assignee: DePuy OrthopeadicsInventors: Dale R. Peterson, Nancy Nousek-Goebl, Todd P. Glancy
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Patent number: 6451342Abstract: This invention relates to a controlled release combination drug product comprising troglitazone, e.g. its hydrochloride, and a biguamide, e.g. metformin. In particular, the product comprises a core of metformin, at least a portion thereof has a layer or coat thereon of troglitazone.Type: GrantFiled: February 15, 2001Date of Patent: September 17, 2002Assignee: Aeropharm Technology IncorporatedInventors: Akwete L. Adjei, Yaping Zhu, Anthony J. Cutie
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Patent number: 6444216Abstract: A topical insect repellent with extended duration of protection was obtained from mixtures of molecules based on two or more volatile repellent organic molecular species occurring naturally on the human skin surface. The novel repellent comprises mixtures of lower, intermediate, and higher volatility organic molecules. Active ingredients for formulations are obtained from homologous series of carboxylic acids, alcohols, ketones, and lactones which span a similar range of volatility and which occur naturally on the skin surface. Volatile silicone fluid imparts mildness and water repellency to the repellent formulations. The new natural repellent exhibits the longevity and repellency that is comparable to N,N-diethyl-m-toluamide (DEET), a synthetic compound employed in almost all commercial formulations, but the inventive natural repellent is more acceptable than DEET, which has an unpleasant odor and imparts a greasy feel to the skin.Type: GrantFiled: August 13, 2001Date of Patent: September 3, 2002Assignee: Stratacor, Inc.Inventor: William G. Reifenrath
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Patent number: 6440406Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.Type: GrantFiled: June 12, 2000Date of Patent: August 27, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University SystemInventors: Juan D. Lopez, Jr., Robert L. Crocker, Ted N. Shaver
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Patent number: 6436444Abstract: The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The .compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.Type: GrantFiled: September 26, 1997Date of Patent: August 20, 2002Assignee: Ecolab Inc.Inventors: Francis L. Richter, Cathy M. Paquette, Richard K. Staub
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Patent number: 6436438Abstract: A multiple unit oral pharmaceutical dosage form having a plurality of pellets in a water soluble capsule or in a tablet compressed from the pellets, wherein each pellet contains (a) a substantially inert core, (b) an active ingredient layer over the inert core, and containing (i) a pharmacologically active particulate active ingredient, (ii) a nonembedding amount of a binder for adhering the active ingredient over the inert core, and optionally (iii) a pharmaceutically acceptable, inert adjuvant, such as colloidal silica, and (c) a coating over the active ingredient layer for retarding the release of the active ingredient from the active ingredient layer into an aqueous body fluid solvent in situ, the nonembedding amount of the binder is suitably from about 1% wt. to about 10% wt.Type: GrantFiled: July 8, 1999Date of Patent: August 20, 2002Assignee: Asto-Medica AGInventors: Helmut Momberger, Marc Raber, Dieter Kuhn, Wolfgang Schmid
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Patent number: 6432450Abstract: The effervescent granules with delayed effervescent effect consist of at least one acid component and one component evolving gas under the action of acid, as well as of active substances, fragrances, plant extracts, vitamins, minerals etc. admixed as needed, the particles of the acid component being coated with—preferably 1 to 30% by weight of—at least one carbonate compound—possibly including a partial reaction—and/or a hydrocolloid. The gas-evolving component consists of alkali hydrogen carbonate, alkali carbonate, and/or alkaline-earth carbonate particles which are coated with at least one further substance, particularly with a melt of polyethylene glycol 6000. The particles preferably have a grain size above 0.2 mm.Type: GrantFiled: September 6, 2000Date of Patent: August 13, 2002Inventors: Gerhard Gergely, Irmgard Gergely, Thomas Gergely
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Patent number: 6426317Abstract: Dry, stable, high available halogen sanitizing granular compositions with a rapid rate of dissolution comprising halogenated 1,3,5-triazine-2,4,6-triones and a dissolution accelerant that is an alkali metal salt of 1,3,5-triazine-2,4,6-trione are disclosed. The disclosed compositions may include inorganic and/or organic disintegration agents. Additionally, these compositions may contain other performance enhancing additives such as water clarifiers, algaestats/algaecides, surfactants, glidants, processing aids, and binders. These UV stable sanitizing compositions contain a high available halogen content, and are stable even when stored in high-humidity environments.Type: GrantFiled: October 29, 1999Date of Patent: July 30, 2002Assignee: Great Lakes Chemical CorporationInventors: John P. Garris, Christopher Reed, Michael Engram
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Patent number: 6419956Abstract: A coating for masking or reducing the detectable presence of certain characteristic odor or odors, taste or tastes of pharmaceutical preparations, particularly Valerian extracts, is described. The coating comprises from one to three coating compartments, in any combination or as a single-layer amalgam. The first coating compartment comprises a hydroxyalkyl cellulose and an anti-tackiness agent The second coating compartment may comprise a sugar and at least one anti-tackiness agent. The third coating compartment may comprise a methacrylate copolymer, a hydroxyalkyl cellulose and an anti-tackiness agent.Type: GrantFiled: December 30, 1999Date of Patent: July 16, 2002Assignee: Ancile PharmaceuticalsInventors: I-Lan T. Sue, Pou-Hsiung Wang
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Patent number: 6403642Abstract: Compositions for adsorbing sulfur-containing compounds and eliminating or reducing odors associated with the ingestion of foods or medicines causing sulfur odor, such as garlic and onions, contain a metal complex of a substrate and a ligand. The complex may be contained in a carrier, such as a silica gel, and has low solubility in an aqueous environment. The ligand of the compositions may comprise an amino acid containing sulfur, nitrogen, or a carboxylic acid, such as cystine, and the substrate is a metal which may be copper, zinc, or iron.Type: GrantFiled: August 14, 2000Date of Patent: June 11, 2002Assignee: PQ Holding, Inc.Inventor: Kenneth A. Berg
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Publication number: 20020058053Abstract: A cosmetic material in which a silicone compound represented by the following formula (1) is mixed:Type: ApplicationFiled: June 12, 2000Publication date: May 16, 2002Inventors: Tetsuo Nakanishi, Ichiro Ono
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Patent number: 6379712Abstract: The present invention relates to nanosilver-containing antibacterial and antifungal granules (“NAGs”). The NAGs have longlasting inhibitory effect on a broad-spectrum of bacteria and fungi, which include, but are not limited to, Escherichia coli, Methicillin resistant Staphylococcus aureus, Chlamydia trachomatis, Providencia stuartii, Vibrio vulnificus, Pneumobacillus, Nitrate-negative bacillus, Staphylococcus aureus, Candida albicans, Bacillus cloacae, Bacillus allantoides, Morgan's bacillus (Salmonella morgani), Pseudomonas maltophila, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Bacillus subtilis, Bacillus foecalis alkaligenes, Streptococcus hemolyticus B, Citrobacter, and Salmonella paratyphi C. The NAGs contain ground stalk marrow of the plant Juncus effusus L. which has been dispersed with nanosilver particles. The nanosilver particles are about 1-100 nm in diameter. Each of the nanosilver particles contain a metallic silver core which is surrounded by silver oxide.Type: GrantFiled: April 25, 2001Date of Patent: April 30, 2002Assignee: GloboAsia, L.L.C.Inventors: Jixiong Yan, Jiachong Cheng
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Patent number: 6375969Abstract: This invention relates to certain natural diatomaceous earth granule compositions which can be broadcast, i. e., dry spread on the soil to deliver a pesticide or fertilizer. The granules retain their physical integrity when spread, and have the unique property to spontaneously disintegrate when irrigation water is applied or rainfall hits the particle. Upon wetting, the particle disintegrates (blooms) to cover the soil surface. This bloom can cover an area many times the original area covered by the granule. The granules have high loadings of the diatomaceous earth, i.e. from about 35 to about 95 weight percent and contain from about 5 to about 40 weight percent of a surfactant system which exhibits excellent disintegration; rewetting and binding properties. Bioactive compounds can be loaded at up to 60 weight percent of the granule. Bioactive compounds may be formulated products or technical grades and may be homogeneously distributed throughout the granule or spray impregnated onto the granule.Type: GrantFiled: July 6, 1999Date of Patent: April 23, 2002Assignees: Rhodia Inc., Aquatrols Holding Co., Inc.Inventors: Stanley J. Kostka, Rennan Pan, Christopher M. Miller, Norman Robert Pallas
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Patent number: 6376481Abstract: The present invention provides a sterol, stanol or their corresponding acid ester in a form suitable for the manufacture of an oral dosage form. A method for producing the oral dosage form is also provided.Type: GrantFiled: September 2, 1998Date of Patent: April 23, 2002Assignee: McNeil-PPC, Inc.Inventors: Richard D. Bruce, John D. Higgins, Stephen A. Martellucci
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Patent number: 6372255Abstract: A multi-layer tablet for the instant and prolonged release of active substances comprises at least two layers where the first outer layer comprises a mixture of excipients and an active substance, allowing for the immediate release of the active substance within the first layer, and a second layer, arranged in contact with the first layer. The second layer comprises a nonbiodegradable inert porous polymeric matrix in which an active substance is dispersed, allowing for the prolonged release of the active substance within the second layer.Type: GrantFiled: June 21, 2000Date of Patent: April 16, 2002Assignee: Merck Patent GesellschaftInventors: Olivier Saslawski, Laurence Orlando
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Patent number: 6368625Abstract: A dosage form which rapidly disintegrates in the mouth and forms a viscous slurry of either microcapsules or a powder is described. The rapidly disintegrating dosage form is meant for direct oral administration by placing a tablet or capsule in the mouth of a patient. Upon disintegration, a viscosity of the resulting slurry increases so as to form an organoleptically pleasant viscous material which retards the spread of insoluble materials including the drug.Type: GrantFiled: August 11, 1999Date of Patent: April 9, 2002Assignee: Cima Labs Inc.Inventors: John M. Siebert, Rajendra K. Khankari, Unchalee Kositprapa, S. Indiran Pather
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Patent number: 6358525Abstract: A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is hydroxypropylcellulose (HPC) and the second component is at least one other polymer selected from the group consisting of methylcellulose (MC), ethylhydroxyethylcellulose (EHEC), hydroxyethylmethylcellulose (HEMC), hydrophobically modified hydroxyethylcellulose (HMHEC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), carboxymethylhydroxyethylcellulose (CMHEC), carboxymethyl hydrophobically modified hydroxyethylcellulose (CMHMHEC), guar, pectin, carrageenan, agar, algin, gellan gum, acacia, starch and modified starches, co-polymers of carboxyvinyl monomers, co-polymers of acrylate or methacrylate monomers, mono- and co-polymers of oxyethylene and oxypropylene and mixtures thereof and a medicament in a sufficient amount to be therapeutic, with the proviso that low-substituted hydroxypropylcellulose (L-HPC) is excluded from said firsType: GrantFiled: June 30, 1999Date of Patent: March 19, 2002Assignee: Hercules IncorporatedInventors: Jian Hwa Guo, George William Skinner
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Patent number: 6355271Abstract: Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release matrices for biologically active material are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as antigenic material or natural immunoenhancing factor, polynucleotide material, or therapeutic proteins or peptides, partially coating the particle or impregnated therein. The core particles have a diameter between about 300 nm and about 4000 nm, more particularly between about 300 nm and about 2000 nm, and even more particularly between about 300 nm and about 1000 nm, are substantially spherical in shape, and have a substantially smooth surface.Type: GrantFiled: February 3, 2000Date of Patent: March 12, 2002Assignee: Biosante Pharmaceuticals, Inc.Inventors: Steve J. D. Bell, Tulin Morco, Qing He
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Patent number: 6355278Abstract: A formulation for preventing or treating parturient hypocalcemia or milk fever comprises a solution of hydrochloric acid in water, soybean meal, additional feed components and minerals. The feed formulation is prepared by grinding soybean meal to a particle size of 1000 to 2000 microns. A hydrochloric acid solution and feedgrade limestone are blended into the meal to produce the formulation.Type: GrantFiled: March 31, 1999Date of Patent: March 12, 2002Assignee: West Central CooperativeInventors: William D. Stidham, Donald W. Seaman, Myron F. Danzer, James P. Henry
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Patent number: 6350469Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1N hydrochloric acid as well as water.Type: GrantFiled: February 14, 2000Date of Patent: February 26, 2002Assignee: SmithKline Beecham CorporationInventors: Bruce Daggy, Naresh I Mehta, Priyashri Nayak
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Patent number: 6350471Abstract: The invention provides a delayed release tablet, comprising: (i) a core comprising an active ingredient selected from the group consisting of oxybutynin hydrochloride, propranolol hydrochloride, buspiron hydrochloride, niacin, cetirizin hydrochloride, cerivastin sodium, metoprolol fumarate, and alendronate sodium., and conventional excipients; and (ii) a coating consisting essentially of a water-insoluble, water-permeable film- forming polymer, a plasticizer and a water-soluble polymer.Type: GrantFiled: May 31, 2000Date of Patent: February 26, 2002Assignee: Pharma Pass LLCInventor: Pawan Seth
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Patent number: 6340656Abstract: The present invention provides light, extruded compositions and methods for their preparation. The light, extruded compositions comprise at least one agricultural compound; a light, extrudable, ceramic carrier; and at least one surface active agent. The present invention also provides a method for applying agricultural compounds to the water of paddy fields by localized application(s) of the light, extruded compositions to the water surface of the paddy fields.Type: GrantFiled: February 9, 2000Date of Patent: January 22, 2002Assignee: American Cyanamid Co.Inventors: Norikazu Takayanagi, Masaomi Kimpara, Munehiro Suzuki
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Patent number: 6333054Abstract: A thixotropic, non-cytotoxic, topical hydrogel that contains a proven safe and effective, broad spectrum, antimicrobial agent based on a unique electrolytically derived sodium hypochlorite solution.Type: GrantFiled: October 21, 1999Date of Patent: December 25, 2001Assignee: Amuchina S.p.A.Inventor: Wallace Rogozinski