Starch Or Derivative Patents (Class 514/778)
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Publication number: 20140018442Abstract: The present invention relates to novel compositions containing finely dispersed carotenoids. The novel compositions of this invention can be used as colorants or additives for food, beverages, animal feeds, cosmetics or drugs. The colorant composition may be a liquid or a solid composition. The solid composition comprises at least one carotenoid which is dispersed in a matrix, wherein the matrix contains at least one carbohydrate and/or one modified carbohydrate and optionally, a protein, a modified protein or mixtures thereof, wherein the at least one carbohydrate and/or one modified carbohydrate is starch or modified starch, wherein the amount of starch or modified starch is from about 10 wt-% to 60 wt-% of based on the total weight of the matrix, and wherein the concentration of the at least one carotenoid is at least 2% based on the total weight of the composition. Preferably ?-carotene is used as a solid water-dispersible colorant composition.Type: ApplicationFiled: July 12, 2013Publication date: January 16, 2014Applicant: DSM IP ASSETS B.V.Inventor: Karl Manfred VOELKER
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Publication number: 20140011891Abstract: Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.Type: ApplicationFiled: February 21, 2013Publication date: January 9, 2014Applicant: BIOMOLECULAR PRODUCTS, INC.Inventor: BIOMOLECULAR PRODUCTS, INC.
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Publication number: 20140005280Abstract: A carboxymethyl starch and chitosan polyelectrolyte complex is provided. A carrier comprising this polyelectrolyte complex along with a solid oral dosage form comprising this polyelectrolyte complex are also provided. A method of manufacturing the polyelectrolyte complex is also provided.Type: ApplicationFiled: January 19, 2012Publication date: January 2, 2014Applicant: 4413261 Canada Inc. (Spencer Canada)Inventors: Elias Assaad, Mircea-Alexandru Mateescu
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Patent number: 8614255Abstract: The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.Type: GrantFiled: August 21, 2008Date of Patent: December 24, 2013Assignee: Civitas Therapeutics, Inc.Inventors: Charles D. Blizzard, Michael M. Lipp, Kevin L. Ward, Rachel Ryznal, Daniel Leblanc, Mark Tracy, Rebecca Martin
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Publication number: 20130338121Abstract: The present document describes a monolithic tablet dosage form for delivery of an active ingredient at two different release rates comprising a carboxyl polymer complexed with a multivalent cation and a disintegrating agent for a first initial fast release of the active ingredient, and a modulating agent for a second sustained release of the active ingredient. Also described are processes for preparing the carboxyl polymer complexed with a multivalent cation, and carboxyl polymer made from the process.Type: ApplicationFiled: February 28, 2012Publication date: December 19, 2013Inventors: Le Tien Canh, Mircea-Alexandru Mateescu
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Publication number: 20130302309Abstract: The present invention relates to a non-animal soft capsule shell composition having improved disintegration stability and shell hardness. More particularly, the present invention relates to a non-animal soft capsule shell composition and to a method for preparing same, in which an antioxidant and a disintegration aid are added to the non-animal soft capsule shell composition that is typically made of starch or a starch derivative, gums, a plasticizer, a buffering agent, and purified water which inhibit starch retrogradation and thus inhibit an increase in disintegration stability and capsule shell hardness, thereby improving disintegration stability and shell hardness.Type: ApplicationFiled: April 18, 2012Publication date: November 14, 2013Applicant: Suheung Capsule Co., Ltd.Inventor: Joo-Hwan Yang
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Publication number: 20130296385Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.Type: ApplicationFiled: July 11, 2013Publication date: November 7, 2013Inventors: Janos Szamosi, Kevin Scott Kinter, Vincent H. Li, Khawka Abdullah Abu-Izza
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Patent number: 8574624Abstract: The invention provides the addition of highly inhibited starch filler to gelatin-free films and soft capsules. The addition of the highly inhibited starch filler raises the solid levels during processing without substantially increasing the melt viscosity. The resultant films and capsules are transparent.Type: GrantFiled: November 17, 2006Date of Patent: November 5, 2013Assignee: Corn Products Development, Inc.Inventors: Zhixin Li, Michele Merrette Shore, Ralph Trksak
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Publication number: 20130289138Abstract: Composite material suitable for biomedical use, comprising a first phase consisting of a reticulated hydrogel deriving from a polymer chosen from among polymers N-methyl-amides derivatives of carboxymethylcellulose, alginic acid or carboxymethyl starch and a second phase which comprises a solution of the above polymers.Type: ApplicationFiled: December 21, 2011Publication date: October 31, 2013Applicant: LIMACORPORATE SPAInventors: Francesco Segatti, David Mercuri
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Publication number: 20130280304Abstract: The present invention provides an improved method of administering a medicinal, dental or nutritional agent to a non-human animal, such as a domesticated dog or cat. The method comprises mixing a liquid composition in a mixer at various speeds and pressures for a period of time; pouring the liquid composition onto a conveyor belt propelled by polymer rollers, wherein the polymer rollers allow the components to advance on the conveyor belt without adhering to the belt; evenly distributing the composition on the belt with the use of a knife; heating the composition in one or more hot-air chambers; obtaining a film comprised of the composition; cutting the film into strips; and then administering one or more of the strips to the non-human animal by placing the strip under the tongue of the animal, i.e., by sub-lingual administration.Type: ApplicationFiled: October 22, 2012Publication date: October 24, 2013Inventor: Douglas Kramer
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Publication number: 20130267612Abstract: A personal care composition includes a blend of a cold water soluble starch, a naturally derived polymeric thickener and a cosmetically or pharmaceutically acceptable active, where the composition is in the form of a solid.Type: ApplicationFiled: December 19, 2011Publication date: October 10, 2013Inventors: Sarah Thiewes, Gloria C. Tirol
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Publication number: 20130261195Abstract: The present application is related to a micronized starch with an average particle size of less than 5 ?m and a degree of polymerization greater than 100, wherein the micronized starch exhibits at least 20% of the crystallinity of the base granular starch.Type: ApplicationFiled: April 3, 2012Publication date: October 3, 2013Applicant: CORN PRODUCTS DEVELOPMENT, INC.Inventors: Christopher C. Lane, Pingyi Zhang
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Patent number: 8541392Abstract: The present invention relates generally to a method of blunting the postprandial glycemic response in a human by feeding an induced viscosity fiber system. The invention also relates to an induced viscosity fiber system and the liquid products that incorporate the induced viscosity fiber system. Further, the invention relates to a method of incorporating soluble fiber into a liquid product without the typical negative organoleptic or physical stability issues. The invention also relates to a method of inducing the feeling of fullness and satiety by feeding the induced viscosity fiber system.Type: GrantFiled: September 30, 2009Date of Patent: September 24, 2013Assignee: Abbott LaboratoriesInventors: Bryan W. Wolf, Bruce B. Blidner, Keith A. Garleb, Chron-Si Lai, Timothy W. Schenz
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Publication number: 20130231402Abstract: To provide a novel substance having an excellent water-dispersibility capable of forming an emulsion which spreads rapidly onto the skin, does not undergo aggregation or segregation due to a salt, and is excellent in a low temperature stability. The aforementioned problems were found to be solved by means of a certain polysaccharide and the invention was established.Type: ApplicationFiled: August 30, 2012Publication date: September 5, 2013Applicant: Ajinomoto Co., Inc.Inventors: Masayuki Kuramoto, Tatsuya Hattori, Masahiro Ino
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Publication number: 20130216618Abstract: A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Applicant: INNOGEL AGInventor: INNOGEL AG
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Publication number: 20130216623Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Applicant: ISCIENCE INTERVENTIONAL CORPORATIONInventor: ISCIENCE INTERVENTIONAL CORPORATION
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Publication number: 20130210812Abstract: The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.Type: ApplicationFiled: February 8, 2013Publication date: August 15, 2013Applicant: Alcon Research, Ltd.Inventor: Alcon Research, Ltd.
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Publication number: 20130203599Abstract: The present invention provides the agricultural chemical-spreading agent composition, containing: (A) a polysaccharide in an amount of 5 to 30% by weight; (B) a polyoxyalkylene sorbitan fatty acid ester in an amount of 5 to 40% by weight; and (C) at least one nonionic surfactant selected from polyoxyalkylene alkyl ethers, sorbitan fatty acid esters, and silicone surfactants in an amount of 5 to 40% by weight, wherein the component (A) has a viscosity of not less than 5000 mPa·s in the form of a 5% by weight aqueous solution at 25° C., and a weight ratio of contents of the component (A) to the sum of components (B) and (C), (A)/[(B)+(C)], is 10/90 to 40/60.Type: ApplicationFiled: September 1, 2011Publication date: August 8, 2013Applicant: KAO CORPORATIONInventors: Masaki Inoue, Masatoshi Kamei
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Publication number: 20130197100Abstract: The invention “colloidal nanoscale carriers for active hydrophilic substances and method for producing same” pertains to the field of medical, odontological or hygiene preparations, and is characterized by structures formed by hydrophilic polymers that contain active hydrophilic substances coated with a non-hydrophilic phase and surfactants with affinity for the components, forming an invert emulsion that allows the incorporation and controlled delivery of active hydrophilic substances, conferring properties such as protection against degradation processes, improvement of compatibility with the other components of the formulation in the final product, increase in the availability and/or bioavailability of the active substance in the medium of interest (including improvements in permeation processes in biological materials, reduction of the exposure and volatilization of the active substance in the medium) and controlled release of the active substance(s).Type: ApplicationFiled: June 14, 2011Publication date: August 1, 2013Applicants: Instituto De Pesquisas Technologicas Do Estado De Sao Paulo, Rundacao De Amparo A Pesquisa Do Estado De Sao Paulo - FAPESP, Universidade De Sao Paulo - USPInventors: Natália Neto Pereira Cerize, Adriano Marim De Oliveira, Maria Inês Ré, Antônio Cláudio Tedesco
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Publication number: 20130197105Abstract: An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: CyDex Pharmaceuticals, Inc.Inventor: CyDex Pharmaceuticals, Inc.
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Publication number: 20130195769Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: FOAMIX LTD.Inventor: Foamix Ltd.
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Publication number: 20130190839Abstract: An implantable drug-doped component, e.g., a cochlear implant, includes host material, a host-embedded drug and a sacrificial material integrated with the host. Upon exposure of the sacrificial material to a solvent, e.g., perilymph fluid, voids in the host are created which facilitate release of the drug. The host can be, e.g., polysiloxane or silicone rubber. The sacrificial material, e.g., can be a glucose monomer, sugar, cyclodextrin, a salt, a bioresorbable material, hyaluronic acid, polyurethane, polyester, polyamide, polyvinyl alcohol, polyacrylic acid, etc. Alternatively, the sacrificial material can be the host, and can facilitate release of the drug through changing a property of the sacrificial material, e.g., by exposing the component to an ethanol wash. For a cochlear implant, e.g., the drug doped material can be applied to a non-stimulating surface of the electrode array.Type: ApplicationFiled: January 20, 2012Publication date: July 25, 2013Inventors: Jane Rapsey, Martin Svehla, Peter Schuller, Christopher Robert Miller
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Publication number: 20130184357Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.Type: ApplicationFiled: March 7, 2013Publication date: July 18, 2013Applicant: CyDex Pharmaceuticals, Inc.Inventor: CyDex Pharmaceuticals, Inc.
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Patent number: 8486439Abstract: The present invention relates to a kinetic implant comprising(a) biodegradable material comprising opened starch, destructurized starch or a mixture of opened starch and destructurized starch, (b) a biologically or pharmaceutically active substance; and (c) a stabilizing component stabilizing the biologically or pharmaceutically active substance. The biodegradable material comprises about 50 to about 100 wt. % of opened starch, destructurized starch or a mixture of opened starch, based on the total weight of the biodegradable material, the biodegradable material having a bulk density of 1.0 to 1.5 kg/dm3. The kinetic implant has a length :diameter ratio of more than 4, provided that the length of the kinetic implant is between 1 mm to 50 mm. The kinetic implant has a weight such that it can be provided with an amount of kinetic energy in the range of 0.1 to 10 J.Type: GrantFiled: February 29, 2008Date of Patent: July 16, 2013Assignee: Bioneedle Technologies Group B.V.Inventor: Gijsbertus Gerardus Petrus Van De Wijdeven
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Publication number: 20130164354Abstract: Disclosed is a method for the preparation of cosmetic compositions having the texture of a cream. Said preparation is made at the time when the composition is used and includes bringing into contact with each other (A) a liquid phase, (B) a powder containing a gelling agent for the liquid phase (A), and (C) an active cosmetic ingredient, whereby the elements are brought into contact by adding phase (A) to phase (B), subjecting a solid powder containing phase (B) and phase (A) in an immobilized form to mechanical stress to release phase (A). Further disclosed are compositions comprising phase (B) and phase (A) in an immobilized form which are transformed into a cream when applied to the skin).Type: ApplicationFiled: July 10, 2012Publication date: June 27, 2013Inventors: Martine Seu-Salerno, Laurence Fillardet, Virginie Boulier
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Publication number: 20130164341Abstract: Inclusion compounds consisting of certain Angiotensin II AT1 receptor antagonists and cyclodextrins are described. These inclusion compounds are useful in the treatment of hypertension.Type: ApplicationFiled: October 22, 2012Publication date: June 27, 2013Applicant: UNIVERSIDADE FEDERAL DE MINAS GERAISInventor: UNIVERSIDADE FEDERAL DE MINAS GERAIS
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Publication number: 20130158133Abstract: The production of starch containing products such as rice for use in a low glycemic diet as a carbohydrate substitute in diet preparations is disclosed. The preparation may be readily adjusted in form and taste with respect to aroma, texture, consistency, and flavor for utilization in a number of food preparation techniques including baking and frying. The method provides digestible starches from native and commercial starches by controlled heating and/or enzymatic processing and filtration of carbohydrates.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Inventor: Bashir A. Zirkia
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Publication number: 20130131192Abstract: The present invention provides compositions comprising API and at least one amino acid, in particular a liquid API formulation comprising amino acids, and methods and kits related thereto. These amino acids when incorporated into the API composition afford stability to the API formulation.Type: ApplicationFiled: November 2, 2010Publication date: May 23, 2013Inventors: Jianxin Guo, Anthony Klos, Bret Coldren, Deborah Barnette, Mark Manning
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Patent number: 8445460Abstract: The invention relates to soluble, highly branched glucose polymers which are obtained by enzymatic treatment of starch, having a reducing sugars content of less than 3.5%, exhibiting a proportion of ?-1,6-glucosidic linkages of between 20% and 30%, a Mw, determined by light scattering, of between 20·103 and 30·103 daltons, and an osmolality of less than 25 mOsm/kg. The invention likewise relates to a method of obtaining these polymers and to their use in the pharmaceutical and food industries, more particularly in the field of enteral and parenteral nutrition, and in the field of peritoneal dialysis.Type: GrantFiled: February 15, 2007Date of Patent: May 21, 2013Assignee: Roquette FreresInventors: Laëtitia Deremaux, Carole Petitjean, Daniel Wills
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Publication number: 20130122467Abstract: Disclosed herein are compositions that can rapidly evolve oxygen and/or activated oxygen generally including an oxidizing agent (e.g., a peroxide) and an activating agent that has an emission wavelength between about 400 nm and about 570 nm (e.g., Eosin B, Eosin Y, or Erythrosine B). Methods of employing these compositions to whiten teeth, and methods of making these compositions and kits that include some or part of the composition ingredients, are also described.Type: ApplicationFiled: April 29, 2011Publication date: May 16, 2013Applicant: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis
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Publication number: 20130115268Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.Type: ApplicationFiled: December 27, 2012Publication date: May 9, 2013Applicants: TEIKIKOKU SEIYAKU KABUSHIKI KAISHA, TEIKOKU PHARMA USA, INC.Inventors: Teikoku Pharma USA, INC., Teikikoku Seiyaku Kabushiki Kaisha
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Patent number: 8435555Abstract: A method of preparing a salt product comprises the steps of: (i) providing a mixture which comprises salt dissolved in a solvent, said mixture further containing an organic material that is solid under ambient temperature conditions; and (ii) atomising said mixture and evaporating said solvent to produce a salt product comprised of particles of salt incorporating said organic material. The organic material may be a polymer such as a carbohydrate (e.g. maltodextrin or Gum Arabic). Novel salt products are disclosed which comprise hollow particles having a shell formed for individual crystallites of salt. The salt product is useful as a seasoning for food and may be used in lower amounts than conventional salt to provide the same taste. Particular advantages are obtained in the baking of bread.Type: GrantFiled: May 1, 2009Date of Patent: May 7, 2013Assignee: Eminate LimitedInventors: Stephen John Minter, Sarah Maude
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Patent number: 8431619Abstract: An aqueous composition, for alleviating at least one problem that conventional aqueous cosmetic compositions, includes (A) at least one selected from the group consisting of a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5, a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5 and an acyl modified starch with a carbon number of 2 to 18 and a cross-linked product of an acyl modified starch with a carbon number of 2 to 18; and (B) a water-soluble polymer material. When the water-soluble polymer material (B) is an association type poly(meth)acrylate polymer, a nonionic or cationic cellulose polymer, a poly(meth)acrylic acid polymer or xanthan gum, the aqueous composition exhibits excellent viscosity increase ratio and temporal stability.Type: GrantFiled: April 16, 2012Date of Patent: April 30, 2013Assignee: Akzo Nobel N.V.Inventor: Tomohiro Hashimoto
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Patent number: 8431618Abstract: Disclosed are a processed starch powder in which the amount of water soluble component is greater than 2 wt % but less than 10 wt %, the water retention amount is greater than 600% and 1500% or less, and which comprises nonbirefringent particles, and a manufacturing method thereof.Type: GrantFiled: March 30, 2009Date of Patent: April 30, 2013Assignees: Asahi Kasei Chemicals Corporation, Sanwa Cornstarch Co., Ltd.Inventors: Masaaki Endo, Shozo Kaneyama, Kazuhiro Obae, Ichiro Ibuki, Michihiro Sunako, Eishi Wakamiya
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Publication number: 20130096207Abstract: Provided is a water dispersion type sex pheromone sustained release preparation which makes it possible to suppress excess release at the initial stage of spraying and release a sex pheromone substance at a constant amount for a predetermined period, and which can be sprayed by using a common sprayer. Specifically provided is a water dispersion type sex pheromone sustained release preparation, comprising an insect sex pheromone substance which is enclosed in a ring of a cyclodextrin, an inclusion cyclodextrin which encloses the insect sex pheromone substance, a non-inclusion cyclodextrin which does not enclose the insect sex pheromone substance, a water-soluble polymer, and water.Type: ApplicationFiled: October 2, 2012Publication date: April 18, 2013Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Shin-Etsu Chemical Co., Ltd.
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Patent number: 8420120Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: February 3, 2012Date of Patent: April 16, 2013Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Publication number: 20130090237Abstract: In one embodiment, a method includes making a pteredin phenyl pentanedioic (3P) formulation by providing an aqueous solution including one of more 3P molecules neutralized with one or more of an alkali, an alkali earth metal hydroxide, or an alkali carbonate; adding to the aqueous solution one of a surfactant, dispersant, or additive with the guest molecules; and non-covalently crosslinking the 3P formulation by exposing the 3P formulation to an excess solution of multivalent cation salt.Type: ApplicationFiled: October 11, 2011Publication date: April 11, 2013Inventor: Sanat Mohanty
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Publication number: 20130065844Abstract: The present invention is related to pharmaceutical compositions of one or more tiacumicins that exhibit improved stability, and methods of treatment using such formulations. The formulations contain one or more tiacumicins, such as difimicin, and one or more antioxidants, such as butylated hydroxytoluene, and, optionally, one or more pharmaceutically acceptable excipients.Type: ApplicationFiled: March 9, 2012Publication date: March 14, 2013Inventors: Suketu Sanghvi, Mark Roach, Joseph F. Zhou, Eric Michael Mittleberg, Ping He
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Patent number: 8383134Abstract: The present application relates to a biodegradable material comprising opened starch or a mixture of opened starch and destructurised starch. The biodegradable material comprises about 50 to about 100 wt. % of opened starch or of a mixture of opened starch and destructurized starch, based on the total weight of the biodegradable material, said biodegradable material having a bulk density of 1.0 to 1.5 kg/dm. The biodegradable material is used for manufacturing biodegradable shaped articles, wherein said biodegradable shaped articles are suitable for delivery of a biologically or pharmaceutically active component in or to a vertebrate, e.g. a mammal.Type: GrantFiled: February 29, 2008Date of Patent: February 26, 2013Assignee: Bioneedle Technologies Group B.V.Inventor: Gijsbertus Gerardus Petrus Van De Wijdeven
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Publication number: 20130045242Abstract: A hydrogel formulation of oxidized dextrin is reticulated with adipic acid dihydrazide, which may embody polysaccharides, proteins, nanogels, granular materials, bioactive molecules and cells for tissue regeneration and controlled drug delivery. A hydrogel can be injectable, highly biocompatible and biodegradable, for tissue regenerative applications, performing simultaneously as a vehicle e.g. for nanogels, granular materials and cells, and as controlled drug delivery systems, e.g. of hydrophobic molecules and therapeutic proteins.Type: ApplicationFiled: December 9, 2010Publication date: February 21, 2013Applicant: Universidade Do MinhoInventors: Francisco Miguel Portela Da Gama, Maria Cabral Maio Molinos
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Patent number: 8377470Abstract: A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.Type: GrantFiled: July 6, 2012Date of Patent: February 19, 2013Assignee: R.P. Scherer Technologies, LLCInventors: Keith E. Tanner, Rickey S. Shelley, Norman S. Stroud, Elizabeth Youngblood
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Patent number: 8362089Abstract: The invention provides an aqueous composition that can alleviate at least one of the problems that conventional aqueous compositions for cosmetics have (e.g., insufficient temporal stability, insufficient viscosity increase, being incapable of being used in a variety of pH ranges and being incapable of providing sufficient thixotropy). The aqueous composition for cosmetics includes: (A) at least one selected from the group consisting of a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5, a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5 and an acyl modified starch with a carbon number of 2 to 18 and a cross-linked product of an acyl modified starch with a carbon number of 2 to 18; and (B) a water-soluble polymer material.Type: GrantFiled: January 28, 2008Date of Patent: January 29, 2013Assignee: Akzo Nobel N.V.Inventor: Tomohiro Hashimoto
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Patent number: 8362088Abstract: An apparatus, system, and method are disclosed for encapsulating a homeopathic ingredient with a second ingredient. A homeopathic carrier is prepared by applying the homeopathic ingredient to at least one element. The element is selected from the second ingredient, an excipient, and a capsule assembly. The second ingredient is encapsulated in a closed capsule assembly. The closed capsule assembly comprises the homeopathic carrier.Type: GrantFiled: December 13, 2007Date of Patent: January 29, 2013Inventors: W. Matthew Warnock, Shane Hinze
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Patent number: 8362091Abstract: A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: April 26, 2010Date of Patent: January 29, 2013Assignee: Foamix Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
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Patent number: 8354124Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: February 3, 2012Date of Patent: January 15, 2013Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Publication number: 20130005834Abstract: The present invention relates to pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrins as well as their use as osmotic agents, in particular for use in dialysis therapy.Type: ApplicationFiled: March 18, 2011Publication date: January 3, 2013Inventors: Thomas Fichert, Johannes Gerber, Ingo Bichlmaier
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Publication number: 20130005685Abstract: The invention relates to a compound, comprising a) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, wherein the starch derivative has a mean relative molar mass Mw1 and a degree of molar substitution MS1, and b) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, having a mean relative molar mass Mw2 and a degree of molar substitution MS2, characterized in that Mw1 is greater than Mw2 (Mw1>Mw2) and MS2 is greater than MS1 (MS2>MS1).Type: ApplicationFiled: December 6, 2010Publication date: January 3, 2013Applicant: B.Braun Melsungen AGInventors: Bernd Meier, Iris Theresia Jankowiak-Meier, Nele Meier, Clara Meier
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Publication number: 20120328538Abstract: The present disclosure describes a replacement for petroleum jelly as a base for products which is suitable for most any application for which petroleum jelly can be used. The jelly is a glycerine based jelly composition comprising; vegetable derived glycerine and an emulsifier, wherein the emulsifier can be any known and/or commercially available glucoside containing emulsifier. Other suitable emulsifiers together with glycerine and essential or vegetable based oils with or without inorganic fillers may also be added to the jelly to impart fragrance, color, UVA and UVB sun protection factor(s), immuno-enhancing aromatherapeutics, as well as free radical scavenging constituents. In addition, temperature stabilizers and stiffening agents such as waxes and other inorganic fillers including silica and clays may also be added during manufacture as required. The glycerine is preferably present in the range of 50-95%.Type: ApplicationFiled: December 9, 2010Publication date: December 27, 2012Inventors: Guerry L. Grune, William Wingfield
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Publication number: 20120322718Abstract: A starch-based Amygel for the controlled delivery of a biologically active agent is described. The Amygel comprises a dispersed phase, and a dispersion medium consisting substantially of an organic solvent. The dispersed phase includes a polymeric network comprising a hydrolyzable polymeric substance derived from starch, and a cross-linker. In various embodiments, the polymeric starch-derived network includes amylose, amylopectin, soluble starch or a combination thereof. The cross-linker is a molecule having at least two carboxyl moieties. The hyrogel is biocompatible and biodegradable, and suitable for loading with biologically active agents including small molecule therapeutics, macromolecules such as proteins, polysaccharides and nucleic acids. Upon administration to a host animal, the Amygel biodegrades, releasing as degradation products only naturally-occurring sugar molecules that are non-toxic and non-immunogenic to the host.Type: ApplicationFiled: June 18, 2012Publication date: December 20, 2012Inventor: Elizabeth Barker
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Publication number: 20120322750Abstract: Described is a solubilization agent for solubilizing polyphenols, flavonoids and/or diterpenoid glucosides in aqueous liquids, wherein the solubilization agent consists of a mixture of: (a) one emulsifying polymer or a mixture of two, three or more emulsifying polymers, (b) one saponin or a mixture of two, three or more saponins, (c) one partially or fully water-miscible, preferably liquid, solvent or a mixture of partially or fully water-miscible, preferably liquid, solvents, preferably selected from the group consisting of ethanol, propylene glycol (1,2-propanediol), glycerin, triacetin (glycerin triacetate), diacetin (glycerin diacetate) and triethyl citrate, and (d) water. The solubilization agent is particularly suitable for sparingly water soluble polyphenols, flavonoids and/or diterpenoid glucosides. The invention also relates to compositions and (food or cosmetic) formulations comprising said solubilization agent.Type: ApplicationFiled: January 24, 2011Publication date: December 20, 2012Applicant: SYMRISE AGInventors: Dirk Schrader, Thomas Riess, Cornelia Homner, Christopher Sabater-Lüntzel