Starch Or Derivative Patents (Class 514/778)
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Publication number: 20120316108Abstract: The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.Type: ApplicationFiled: June 14, 2012Publication date: December 13, 2012Applicant: Latitude Pharmaceuticals Inc.Inventors: Andrew Xian Chen, Hailiang Chen
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Publication number: 20120301546Abstract: The present disclosure describes a delivery device for administration of nutraceuticals or pharmaceuticals, which device contains a soft gel shell comprising a gelatin-based water soluble film forming polymer, an acid insoluble polymer, and at least one reducing sugar and water, including processes, gel mixtures used for device production, and coatings containing such gel mixtures.Type: ApplicationFiled: May 26, 2011Publication date: November 29, 2012Inventor: Emadeldin M. Hassan
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Patent number: 8318818Abstract: A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.Type: GrantFiled: March 14, 2005Date of Patent: November 27, 2012Assignee: Skinvisible Pharmaceuticals, Inc.Inventors: James A. Roszell, Bruce Jezior
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Publication number: 20120288562Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.Type: ApplicationFiled: September 14, 2010Publication date: November 15, 2012Inventors: Dominique Nicolas Cade, Xiongwei David He
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Publication number: 20120277321Abstract: A method for preparing a composition including a compound based on vanillin and ethyl vanillin is described. A resulting composition and uses thereof in many fields of application, in particular in human and animal food is also described. A method for preparing a composition including a compound based on vanillin and ethylvanillin in a vanillin/ethyl vanillin molar ratio of 2 is also described wherein the method includes: a step of melting a mixture of vanillin and ethyl vanillin, which are used in a molar ratio other than 2, with an excess of vanillin representing from 2% to 20% of the weight of the mixture; a step of solidifying same, by cooling to a temperature of less than or equal to 50° C.±1° C.; and a step of recovering the resulting composition including the new compound.Type: ApplicationFiled: October 1, 2010Publication date: November 1, 2012Inventors: Jean-Claude Le-Thiesse, Kilani Lamiri
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Publication number: 20120259023Abstract: The present invention relates to novel conjugates based on plant gums and modified food starch, a process for the manufacture thereof, as well as to compositions containing active ingredients, preferably fat-soluble active ingredients, and/or colorants in a matrix based on these conjugates, and to a process for preparing these compositions.Type: ApplicationFiled: October 1, 2010Publication date: October 11, 2012Inventors: Andrea Hitzfeld, Bruno H. Leuenberger, Paul Steeman, Olivia Vidoni
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Patent number: 8273378Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.Type: GrantFiled: January 14, 2010Date of Patent: September 25, 2012Assignees: Baxter International, Inc., Baxter Healthcare S.A.Inventors: Bruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
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Publication number: 20120237576Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.Type: ApplicationFiled: September 12, 2011Publication date: September 20, 2012Inventors: Gregory Charles Gordon, Robert Wayne Glenn, JR., Mark Robert Sivk, Mark Ryan Richards, Stephen Wayne Heinzman, Michael David James, Geoffrey William Reynolds, Paul Dennis Trokhan, Paul Thomas Weisman, Alyssandrea Hope Hamad-Ebrahimpour, Frank William Denome, Stephen Joseph Hodson
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Publication number: 20120237462Abstract: An aqueous composition, for alleviating at least one problem that conventional aqueous cosmetic compositions, includes (A) at least one selected from the group consisting of a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5, a cross-linked product of a hydroxyalkyl modified starch with a carbon number of 2 to 5 and an acyl modified starch with a carbon number of 2 to 18 and a cross-linked product of an acyl modified starch with a carbon number of 2 to 18; and (B) a water-soluble polymer material. When the water-soluble polymer material (B) is an association type poly(meth)acrylate polymer, a nonionic or cationic cellulose polymer, a poly(meth)acrylic acid polymer or xanthan gum, the aqueous composition exhibits excellent viscosity increase ratio and temporal stability.Type: ApplicationFiled: April 16, 2012Publication date: September 20, 2012Applicant: AKZO NOBEL N.V.Inventor: Tomohiro Hashimoto
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Publication number: 20120230928Abstract: The present invention relates to compositions containing fat-soluble active ingredients and/or colorants in a matrix based on improved modified polysaccharides, i.e. modified polysaccharides where parts were separated, and to a process for preparing these compositions as well as to these improved modified polysaccharides themselves and a process for the manufacture thereof. The present invention further relates to the use of the compositions of this invention for the to enrichment, fortification and/or for the coloration of food, beverages, animal feed, cosmetics and pharmaceutical compositions and to such food, beverages, animal feed, cosmetics and pharmaceutical compositions themselves.Type: ApplicationFiled: April 23, 2012Publication date: September 13, 2012Applicant: DSM IP ASSETS B.V.Inventors: David SCHAFFNER, Christian SCHÄFER, Bernd SCHLEGEL
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Patent number: 8263124Abstract: The present invention relates to pharmaceutical compositions of antihistamine-decongestant combination. Specifically the invention relates to bilayered tablet formulation comprising antihistaminic decongestant combination. More specifically present invention relates to the novel polymorph of fexofenadine or pharmaceutically accepted salts thereof, with at least one decongestant in the form of bilayered tablet. The preferred polymorphs are polymorph A and polymorph X of fexofenadine hydrochloride.Type: GrantFiled: April 4, 2002Date of Patent: September 11, 2012Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.Inventors: Kamalakar Talasila, Debashis Dash, Srinivas Irukula, Dhanorkar Vipin Tatyasaheb, Mailatur Sivaraman Mohan
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Publication number: 20120219525Abstract: Stable thickener formulations and nutritional compositions having the stable thickener formulations are provided. In a general embodiment the present disclosure provides a stable thickener formulation comprising from about 0.015% to about 0.05% by weight of carrageenan and from about 1.2% to about 4.0% by weight of starch. The stable thickener formulation can be used in nutritional compositions used to treat a variety of physiological conditions.Type: ApplicationFiled: October 25, 2010Publication date: August 30, 2012Applicant: Nestec S.A.Inventor: Erin Olson
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Publication number: 20120219628Abstract: There is provided a fast dissolving solid dosage form adapted for the release of a biologically active material in the oral cavity wherein the dosage form comprises at least one biologically active material, and at least one matrix forming agent, wherein the dosage form substantially dissolves in the oral cavity. A method of producing the same and a kit comprising the same are also provided.Type: ApplicationFiled: October 26, 2010Publication date: August 30, 2012Applicant: IX BIOPHARMA PTE LTDInventors: Chin Beng Stephen Lim, Vivian Bruce Sunderland, Yip Hang Eddy Lee
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Patent number: 8252276Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: March 15, 2012Date of Patent: August 28, 2012Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120208897Abstract: The present invention relates to a continuous method for preparing acetylated derivatives of an amylaceous material. The invention also relates to a solid composition of at least one acetylated derivative of an amylaceous material obtained by means of said method. The invention finally relates to the use of such a composition to prepare thermoplastic, elastomeric, adhesive, pharmaceutical and/or ink compositions.Type: ApplicationFiled: October 11, 2010Publication date: August 16, 2012Applicant: ROQUETTE FRERESInventor: Claude Quettier
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Publication number: 20120201901Abstract: A biocompatible putty formulation suitable for insertion within chronic and acute wounds of humans and animals, the formulation containing a topical antibiotic, a biocompatible humectant, a biocompatible viscosity-building agent, and at least 5% water, by weight, the humectant and the viscosity-building agent intimately mixed within the formulation, the formulation adapted whereby the formulation remains a solid over the entire temperature range of 20° C. to 35° C.Type: ApplicationFiled: February 6, 2011Publication date: August 9, 2012Applicant: AIDANCE SKINCARE & TOPICAL SOLUTIONS, LLCInventors: Perry Antelman, David Goldsmith, Shalom Lampert
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Publication number: 20120202839Abstract: This invention relates to an abuse deterrent formulation of an oral dosage form of a therapeutically effective amount of any active drug substance that can be subject to abuse combined with a gel forming polymer, a nasal mucosal irritating surfactant and a flushing agent. Such a dosage form is intended to deter abuse of the active drug substance via injection, nasal inhalation or consumption of quantities of the dosage unit exceeding the usual therapeutically effective dose.Type: ApplicationFiled: April 18, 2012Publication date: August 9, 2012Applicant: ACURA PHARMACEUTICALS, INC.Inventors: James F. EMIGH, Ronald L. LEECH, JR., Andrew D. REDDICK, Ron J. SPIVEY
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Patent number: 8231896Abstract: A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.Type: GrantFiled: November 8, 2004Date of Patent: July 31, 2012Assignee: R.P. Scherer Technologies, LLCInventors: Keith E. Tanner, Rickey S. Shelley, Norman S. Stroud, Elizabeth Youngblood
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Publication number: 20120189694Abstract: The invention relates to a co-precipitate comprising a phosphodiesterase-5 inhibitor (PDE-5-inhibitor) and a pharmaceutically compatible copolymer carrier comprising 2 or more different acrylic acid derivatives, a method for production thereof and a medication comprising the co-precipitate according to the invention, a method for producing said medication and the use of said medication for treating an illness wherein the inhibiting of phosphodiesterase-5 is of therapeutic benefit.Type: ApplicationFiled: July 8, 2010Publication date: July 26, 2012Applicant: ratiopharm GmbHInventors: Katrin Rimkus, Frank Muskulus
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Publication number: 20120184627Abstract: The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.Type: ApplicationFiled: September 24, 2010Publication date: July 19, 2012Inventors: Michael Crowley, Amanda Gage, Jack Maegli, Timothy O'Reilly
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Publication number: 20120183585Abstract: The various embodiments herein provide a gel based wound dressing comprising a lyophilized powder and a water-based solvent. The lyophilized powder comprises several nanoparticles and water miscible natural or synthetic polymers. The nanoparticles comprises pectin and a wound healing agent or an anti-microbial agent. The anti-microbial agent is nisin. The lyophilized powder and the water-based solvent are kept in two separate sealed packages and are mixed together before applying on a wound. The embodiments herein also provide a method of synthesizing the gel based wound dressing. The nano-particles control a release of the wound healing agent or the antimicrobial agent to a wound.Type: ApplicationFiled: February 25, 2012Publication date: July 19, 2012Inventors: Rassoul Dinarvand, Nasrin Samadi, Azade Taheri Borujeni
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Publication number: 20120156261Abstract: There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.Type: ApplicationFiled: August 11, 2010Publication date: June 21, 2012Inventors: Keiichi Fujiwara, Tadashi Fukami, Haruka Koizumi
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Publication number: 20120142787Abstract: Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.Type: ApplicationFiled: December 21, 2010Publication date: June 7, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Helen S. M. LU, STEVEN W. SHUEY
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Publication number: 20120141551Abstract: A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.Type: ApplicationFiled: December 2, 2011Publication date: June 7, 2012Applicant: ECOSYNTHETIX LTD.Inventors: Steven BLOEMBERGEN, Ian J. MCLENNAN, Nathan JONES, Ryan WAGNER, Aareet Krsna GANESH SHERMON, Abdel Rahman ELSAYED, Juewen LIU
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Publication number: 20120136072Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.Type: ApplicationFiled: September 23, 2011Publication date: May 31, 2012Inventors: Gerold L. Mosher, James D. Pipkin, Douglas B. Hecker
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Publication number: 20120129951Abstract: The invention relates to a liquid vehicle that can be used to create suspensions and/or solutions of liquid or powdered medications. The vehicle is thixotropic and has improved stability and rheologic characteristics. Vehicles of the invention include an aqueous medium and a suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages. The polysaccharide can be a starch, modified starch, or glycogen. The aqueous medium and individual components of the vehicle provide a palatable and easily ingested drug preparation. The invention also provides a vehicle containing an aqueous medium, suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages, buffer, and artificial sweetener, the combined suspending vehicle having a pH of about 3 to about 10 and an osmolality of 300 mOmsol or less.Type: ApplicationFiled: August 11, 2011Publication date: May 24, 2012Applicant: Gallipot, Inc.Inventors: Joshua Radke, Michael Jones, Martin Erickson
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Publication number: 20120121459Abstract: This invention relates to an aqueous polymer composition and to films formed from this aqueous composition. The aqueous composition may be used in a method for removing contaminate material from a substrate. The aqueous polymer composition may comprise: water; and at least one water-soluble film forming polymer. In one embodiment, the aqueous composition may further comprise at least one chelating agent and/or at least one surfactant. The aqueous polymer composition may be applied to a contaminated substrate or to a clean substrate which is subjected to subsequent contamination. The aqueous composition may be dehydrated and/or the polymer may be crosslinked to form a film. When applied to a contaminated substrate, the film may combine with the contaminates. When applied to a clean substrate, the contaminate material may subsequently contact and adhere to the film.Type: ApplicationFiled: February 28, 2007Publication date: May 17, 2012Inventors: Garry Edgington, Shaosheng Dong, Ge Ming Lui, Hank Wuh, Stephen L. Sherman
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Publication number: 20120122997Abstract: There is provided a plastic or gel material comprising a mixture of: (a) a compound of formula (I) or a mixture of two or more compounds of formula (I), (R?)n(Xn?) (I) or a hydrate thereof, wherein n, R+ and Xn? have meanings given in the description; (b) one or more uncharged organic compounds, each of which compounds comprises at least one oxygen atom and at least one hydrogen atom that is capable of forming a hydrogen bond with Xn?; and (c) one or more polysaccharides, wherein each polysaccharide is a polymer of pyranose monomers, at least 30% of which monomers are in the ?-anomeric conformation. There is also provided articles formed from such materials, uses of such materials and processes for forming such materials.Type: ApplicationFiled: June 29, 2010Publication date: May 17, 2012Inventors: Andrew P. Abbott, Andrew Ballantyne
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Patent number: 8168217Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: July 31, 2007Date of Patent: May 1, 2012Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Publication number: 20120087982Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.Type: ApplicationFiled: December 15, 2011Publication date: April 12, 2012Applicant: ACURA PHARMACEUTICALS, INC.Inventors: Vijai Kumar, David Dixon, Divya Tewari, Dilip B. Wadgaonkar
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Publication number: 20120088849Abstract: Conventional dried materials have a low oil adsorption property and oil retention ability. Therefore, a dried material that has an excellent oil adsorbing property and oil retention ability has been desired. Accordingly, an object of the present invention is to provide an oil-adsorbing composition that has an excellent oil adsorption property and oil retention ability; a method for producing the oil-adsorbing composition; and a method for using the oil-adsorbing composition.Type: ApplicationFiled: October 4, 2011Publication date: April 12, 2012Applicant: MATSUTANI CHEMICAL INDUSTRY CO., LTD.Inventors: Seizo TAKAOKA, Yasutoshi HISHIKAWA, Hiroyuki KATAOKA
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Patent number: 8153152Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: July 31, 2007Date of Patent: April 10, 2012Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Patent number: 8147870Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: July 31, 2007Date of Patent: April 3, 2012Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Publication number: 20120065275Abstract: An aqueous composition characterized in that it comprises one or more anionic polysaccharides suspended in an aqueous dispersion of one or more hydrocolloids.Type: ApplicationFiled: May 17, 2010Publication date: March 15, 2012Applicant: CARGILL INCORPORATEDInventors: Anges Bernard Makoundou, Dogan Sahin Sivasligil
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Patent number: 8133507Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.Type: GrantFiled: December 15, 2003Date of Patent: March 13, 2012Assignee: Durect CorporationInventors: Su Il Yum, Grant Schoenhard, Arthur J. Tipton, John W. Gibson, John C. Middleton
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Publication number: 20120053249Abstract: Co-agglomerates of crystalline mannitol and granular starch, characterised in that they have a compressibility, as determined according to a test A, higher than 120 N, and preferably of 200 to 450 N, and a flow time, as determined according to a test B, of 3 to 15 seconds, and preferably of 4 to 8 seconds.Type: ApplicationFiled: April 28, 2010Publication date: March 1, 2012Applicant: ROQUETTE FRERESInventors: Baptiste Boit, Alain Francois, Philippe Lefevre, Damien Passe
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Publication number: 20120052038Abstract: The present application relates to organosilicones and compositions such as consumer products comprising such organosilicones, as well as processes for making and using such organosilicones and such compositions. Such compositions comprising such organosilicones are easier to formulate, and provide more economical and superior care benefits when compared to current silicone containing compositions.Type: ApplicationFiled: September 30, 2011Publication date: March 1, 2012Inventors: Rajan Keshav PANANDIKER, Luke Andrew Zannoni, Steven Daryl Smith, Robert Joseph Mcchain, Bernard William Kluesner, Rebecca Ann Seger, Julie Ann Menkhaus, Michael Albert Snyder, Joseph Harry Jansen, Marjorie Mossman Peffly
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Patent number: 8110179Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: July 25, 2007Date of Patent: February 7, 2012Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120027838Abstract: Filaments containing a filament-forming material and an additive, such as an ingestible active agent, nonwoven webs, and methods for making such filaments are provided.Type: ApplicationFiled: September 12, 2011Publication date: February 2, 2012Inventors: Gregory Charles Gordon, Robert Wayne Glenn, JR., Mark Robert Sivik, Mark Ryan Richards, Stephen Wayne Heinzman, Michael David James, Geoffrey William Reynolds, Paul Dennis Trokhan, Paul Thomas Weisman, Steven Ray Gilbert, Trevor John Darcy
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Publication number: 20120027694Abstract: This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in an applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing anti-caries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.Type: ApplicationFiled: October 7, 2011Publication date: February 2, 2012Inventors: Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn, Johannes Wilhelmus Timmermans, Theodoor Maximiliaan Slaghek, Jacobus Johannes Frederik van Veen, Johannes Wilhelmus Leonardus Boumans
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Patent number: 8088744Abstract: The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative represented by formula (1): (wherein G represents GlcNAc-Gal-, GlcNAc-Gal-Glc-, Fuc-Gal-, Gal-Glc-, Gal-, or GlcNAc-) or a cyclodextrin inclusion compound thereof, and an anti-cancer agent.Type: GrantFiled: September 3, 2009Date of Patent: January 3, 2012Assignees: Otsuka Pharmaceutical Co., Ltd., National University Corporation Gunma UniversityInventors: Shin Yazawa, Toyo Nishimura, Takayuki Asao
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Publication number: 20110318285Abstract: The present invention relates to a personal care composition additive for use on keratin substrates in order to provide long lasting benefits to the keratin substrate such as in conditioning systems, such as 2/1 shampoo's, leave-on and rinse off conditioners, for hair and skin, or for imparting greater water resistance to such personal care compositions as sunscreens or cosmetics.Type: ApplicationFiled: June 24, 2011Publication date: December 29, 2011Applicant: Hercules IncorporatedInventors: Paquita ERAZO-MAJEWICZ, Gijsbert Kroon, Thi Hong Lan Le-Pham, Tuttu Maria Nuutinen
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Publication number: 20110319503Abstract: A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.Type: ApplicationFiled: March 3, 2010Publication date: December 29, 2011Inventors: Rolf Muller, Federico Innerebner
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Publication number: 20110305768Abstract: This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the thin film and provide protection to components encapsulated within. The invention further describes methods to incorporate bioactive components encapsulated within pH-sensitive polymeric microparticles into a quick-dissolving thin film strip while maintaining the bioactivity of the contained therapeutic agents during thin film formation and microencapsulation.Type: ApplicationFiled: December 24, 2008Publication date: December 15, 2011Applicant: The Johns Hopkins UniversityInventors: Hai-Quan Mao, Christopher Ku Yu, Vu Linh Truong, Yang Li, Dhanya Rangaraj, Xuesong Jiang, Sagar Ramesh Shah, Derek Sing
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Publication number: 20110281940Abstract: Disclosed herein are a method for preparation of an inclusion-complex including a physiologically active hydrophobic substance in cjclodextrin and a derivative thereof, and use of the inclusion-complex prepared by the same. More particularly, the present invention provides a method for preparing an inclusion-complex, which includes agitating cjclodextrin and a derivative thereof in an agitator at high speed, spraying a physiologically active hydrophobic substance dissolved in alcohol onto the agitator, and drying and crushing the mixture obtained from the preceding step and, in addition, use of the prepared inclusion-complex. The present inventive method has merits of reduced inclusion time and increased inclusion rate. The prepared inclusion-complex has excellent cell and collagen proliferation effects compared to physiologically active hydrophobic substances which were not inclusion processed, thereby being used in production of a cosmetic composition with improved anti-wrinkle and anti-ageing effects.Type: ApplicationFiled: September 3, 2008Publication date: November 17, 2011Applicant: MACROCARE TECH., LTD.Inventors: Moo-Sung Kim, Sang-Rin Lee, Yong-Dae Park
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Publication number: 20110269850Abstract: The field of the invention generally relates to a shellac-based enteric coating with a reliable and consistent dissolution profile in both acid and neutral environments based on the selective choice of coating excipients used with the shellac. The enteric coating formulation includes a shellac, a maltrin, sodium alginate, one or more plasticizers, and optionally talc. The shellac is present in a range of approximately 40% to 60% w/w % and has an acid number of between 71 and 73. The maltrin is present in a range of approximately 15% to 30% w/w %. The sodium alginate is present in a range of approximately 15% to 30% w/w %. The one or more plasticizers are present in a range of approximately 2% to 20% w/w %. The optional talc is present in a range of 0% to 10%.Type: ApplicationFiled: April 28, 2010Publication date: November 3, 2011Inventors: Charles A. Signorino, Terry L. Smith, Stephen Levine
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Publication number: 20110268666Abstract: A novel gastroretentive delivery system comprising a tablet comprising a pharmaceutical ingredient or diagnostic, which tablet comprises a gas releasing ingredient or a tandem of two gas releasing ingredients, an ingredient capable of unrestricted swelling in gastric fluid, an ingredient capable of limiting the unrestricted swelling and a hardening ingredient. The said system is based on the use of three different gastroretentive mechanisms: flotation, swelling and mechanical strength, the three mechanisms acting in a complimentary way. Processes for manufacturing same and methods of treatment are also disclosed.Type: ApplicationFiled: September 29, 2009Publication date: November 3, 2011Inventors: Michael Friedman, David Kirmayer
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Publication number: 20110257628Abstract: Provided is an instrument for alleviating addictive drug craving which can be safely administered to an addictive drug-dependent patient by a definite method in practice without causing any undesirable effects on therapy and terminate a series of behaviors through the administration so as to achieve an excellent effect on the therapy for alleviating addictive drug craving. An instrument for alleviating addictive drug craving (11) which comprises a pseudo injection agent (31) enclosed in a pseudo container (21). To the outer face of the pseudo container (21), which is an ampule-shaped container being similar in appearance and structure to a container of an addictive drug (X), a pseudo injection agent label (41), which is almost the same in constitution to a product label of the container of the addictive drug (X) except having the term “PSEUDO” added hereto, is attached.Type: ApplicationFiled: December 2, 2009Publication date: October 20, 2011Inventor: Shinji Hirai
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Publication number: 20110250249Abstract: Provided are cold process formulation aids, methods for their manufacture, and personal care products made using them. The cold processing aids include a wax and a polymer having a backbone and a plurality of pendant groups thereon that are pendant ionic or ionizable groups, or pendant groups having at least one permanent dipole that includes an alcohol, thiol, ester, amide, imide, imine, or nitrile moiety. The backbone can be an aliphatic backbone, a polysaccharide backbone, a siloxane backbone, or a polyamide backbone. Also provided is a method of making personal care products using the cold processing aid.Type: ApplicationFiled: April 7, 2011Publication date: October 13, 2011Inventors: Juan R. Mateu, Adam Perle
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Publication number: 20110243872Abstract: A carbohydrate treatment composition composing modified starches, preservatives, an incorporation factor and water The treatment composition may also preferably comprise a fragrance The composition may be used to coat a litter material substrate and also may be used in a fragrance delivery composition for personal care products A method of coating a litter material using a carbohydrate material is also presented.Type: ApplicationFiled: December 18, 2009Publication date: October 6, 2011Applicant: BELL FLAVORS AND FRAGRANCES, INC.Inventors: Richard Skrobanski, Dina Piersawl, Stephen E. Schuh, Norman J. Appel