Abstract: The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.

Abstract: The present invention concerns an improved shampoo composition, an improved oil composition and an improved method for the treatment of cradle cap (seborrhea dermatitis) primarily in infants and small children. In the improved method, the scalp of an infant is treated with the improved oil followed by gentle brushing and the scalp is then contacted with the improved shampoo and water. Usually the cradle cap condition is eliminated in 1 to 5 days. A kit including the oil, shampoo, sponge, brush, fine toothed comb and optional separate instructions are described.

Abstract: The present invention relates to compounds corresponding to the formula: ##STR1## the compounds being in the form of mixtures of isomers at least on the amino alcohol part of the said formula (I). The invention also relates to a process for their preparation and their use, in particular for the treatment and care of the skin, the hair, the nails and the eyelashes in cosmetics or in dermatology.

Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of a DNA topoisomerase.

Abstract: A process and product restoring hair to bald-headed men involves massaging the scalp with a commercially available ointmenmt known as BAG BALM.

Abstract: Hair regeneration compositions containing T.alpha.1, T.beta.4, or a combination thereof for treating alopecia on the scalp of a patient in need thereof are disclosed. Teatment methods include (1) cleansing the scalp with a cleansing agent; (2) treating the cleansed scalp with a keratin solvent system; (3) applying a topical anesthetic (optional); (4) applying an acid peel solution; (5) applying a hyperactive urea gel formula (optional) and (6) applying a hair regeneration composition.

Abstract: An external skin treatment composition containing (I) vitamin A (retinol) and (II) as a stabilizer, a chelating agent/a polysaccharide, an oil, polyethylene (propylene) glycol, a hydroxy carboxylate, a neutral amino acid salt, an oil-soluble antioxidant/EDTA/a benzophenone compound, an oil-soluble antioxidant/an acid/a benzophenone compound, an inclusion compound of cyclodextrin including an antioxidant and/or an ultraviolet absorber, butanediol and/or an oil-soluble antioxidant, a water-soluble benzophenone compound, a basic amino acid and the salt thereof, an acidic amino acid and the salt thereof, a polar oil, a water-swellable clay mineral.

Abstract: The invention relates to cosmetic compositions of improved rinsability, comprising an oily phase and a citric acid ester corresponding to formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which may be identical or different, represent a hydrogen atom, an alkali metal or alkaline-earth metal, an ammonium cation or a cation of an organic base or a group of formula (II):--(C.sub.n H.sub.2n --O).sub.m --R.sub.4 (II)with n=2, 3 or 4m=5-30and R.sub.4 represents a saturated, linear or branched C.sub.8 -C.sub.24 alkyl group, at least one of R.sub.1, R.sub.2 and R.sub.3 being a group of formula (II). These compositions are used in particular for cleansing and/or removing make-up from the skin.

Abstract: The invention relates to therapeutic formulations containing 75 to 85% by weight of a serenoa repens extract, 2 to 5% by weight of vitamin B6, 2 to 5% by weight of vitamin B3, 2 to 5% by weight of zinc salt, and 10 to 15% by weight of L-arginine. The therapeutic formulations can be used to treat male pattern baldness by topical application to the hair.

Abstract: The use of liposomogenic UV absorbers for protecting human hair from the damaging effect of UV radiation is described. The liposomogenic UV absorbers comprise a hydrophilic head group (=Z), a spacer (=W), a UV chromophore (Q) having an absorption in the range from 285 to 400 nm and at least one hydrophobic tail group (=A). They have the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are a hydrophobic radical;Q is a UV chromophore;W is an organic radical;Z.sub.1 and Z.sub.2 independently of one another are a hydrophilic radical; n.sub.1 and n.sub.2 independently of one another are a number from 0 to 4, where n.sub.1 =n.sub.2 = is not included;p is 1 or 2;q is a number from 0 to 3;r.sub.1 is 1 or 2;r.sub.2 is 0 or 1; ands.sub.1 is a number from 1 to 3.The liposomogenic UV absorbers are capable of self-organization into bimolecular layers, and can as a result penetrate into the stratum corneum to a high degree and are extremely resistant to washing out there.

Abstract: The present invention is an orally- or topically-administrable composition for preventing and treating hair loss. The invention is a plant or plant extract containing isoflavones having a weak estrogen activity. The invention further includes methods for using the invented composition to prevent and treat hair loss.

Abstract: The invention provides compositions for relaxing and conditioning keratinous fibers, particularly human hair. The compositions of the present invention have a high pH, i.e., a pH greater than 10, preferably, in the range of about 11 to about 14, more preferably about 12 to about 13.5, and include as a conditioning additive a cationic guar. Surprisingly, the cationic guar maintains stability, viscosity and activity over time in the highly alkaline pH of the inventive hair relaxer and conditioning compositions of the present invention. The relaxer compositions of the present invention afford beneficial effects to the user, such as softness and ease of wet combing, and cause less damage to hair following application and use. In addition, the conditioning relaxer compositions of the present invention remain on the hair and provide lasting conditioning and relaxing effects after one or more shampoos.

Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-linked sulfonamides of heterocyclic thioesters.

Abstract: The present invention provides compositions that inhibit apoptosis, methods for making the compositions, and methods of use thereof.

Abstract: Methods and compositions for inducing or stimulating the growth of body or cranial hair using a peptide which comprises the Lysine-Proline-Valine sequence are described.

Abstract: Combinations, in particular for use as the active principle in a cosmetic or pharmaceutical and particularly dermatological composition, containing 1-6 parts by weight of peroxidised lipids per 0.01-0.1 parts by weight, based on the organic silicon, of a biologically active organosilicon derivative, are disclosed. Cosmetic or dermatological compositions containing such combinations are also disclosed. Said compositions are particularly useful for treating alopecia.

Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.

Abstract: Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.

Abstract: A hair conditioner composition comprising, by weight of the total composition:0.1-20% of a cationic conditioning agent,0.1-20% of esters of alpha or beta hydroxy acids,0.1-30% of a fatty alcohol,0.001-10% of a nonionic surfactant, and5-95% water.

Abstract: A regimen for inducing/stimulating hair growth and/or retarding hair loss on an individual in need of such treatment comprises topically applying to the affected hair and/or scalp of such individual, a hair growth stimulating and/or hair loss retarding effective amount of at least one 2,3-dihydroxypropyl-2-(1-oxohydrocarbyl) amino-2-deoxyglucopyranoside having the structural formula: ##STR1## in which R is a linear or branched, saturated or unsaturated hydrocarbon radical having from 5 to 21 carbon atoms.

Abstract: A hair care product contains a yolk antibody (a yolk-derived, anti-hair antibody) which has been obtained from an egg of a domestic fowl immunized using, as an antigen, whole human hair, e.g., normal human hair or human hair damaged by permanent waving, dyeing or bleaching, hair particles obtained by grinding constituent tissues of human hair, the keratin protein extracted from the human hair, or a hydrolysate of the keratin protein.

Abstract: A steroid derivative is used as a blood flow amount-improving agent, which is blended with a cosmetic preferably in a ratio of 0.000001 to 10% by weight with respect to a total amount of the cosmetic.

Abstract: Treatments are disclosed which comprise formulations of one or more terpenes in aqueous solutions. No resistance to the formulation of the invention has been seen. When used on the scalp or body no extended dwell time is required. The formulations do not have unpleasant odors associated with prior art shampoo treatments for lice and are preferable on grounds of safety to neurotoxins, which are the usual active ingredients associated with prior art treatments. The formulations are directed towards providing topical preparations which may be used on the scalp and hairy body parts, a spray for use on fabrics, a dipping solution for combs and a laundry additive.

Abstract: The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.

Abstract: The present invention relates to .DELTA..sup.16 unsaturated steroids which are useful as steroid C.sub.17-20 lyase inhibitors.

Abstract: The present invention relates to methods of protecting against injury to hair follicles in a mammal by administering an effective amount of butyric acid or a biologically active butyric acid derivative. In particular, this invention relates to the use of cell differentiation-inducing butyric acid derivatives to protect against hair loss in cancer patients undergoing chemotherapy and/or radiation therapy.

Abstract: A regimen for inducing/stimulating hair growth and/or retarding hair loss on an individual in need of such treatment, comprising administering thereto, advantageously topically and for such period of time as required to elicit the desired effect, an effective amount of at least one RXR-type retinoid receptor agonist preferably having the structural formula(I): ##STR1## in which Ar is one of the following radicals: ##STR2##

Abstract: The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.

Abstract: This disclosure relates to a derivative of L-ascorbic acid which is stable, easily incorporated into cosmetically acceptable vehicles and enzymatically bioreversible in the skin to free ascorbic acid and a safe alkanol component. The L-ascorbic acid derivative includes cholesterol. The L-ascorbic acid derivative is a compound selected from the group consisting of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, isomers thereof and salts thereof.

Abstract: This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate compounds.

Abstract: Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: A hair growth promoter capable of acting as a cosmetic, reducing alopecia, eliminating alopecia, increasing hair growth or any combination thereof is disclosed. The hair growth promoter comprises a colloidal silver, copper and gold complex in a cosmetically acceptable carrier, formed from silver, copper and gold colloids made electrically. The promoter is applied to a treatment area in an amount sufficient to wet the scalp at least one time a week.

Abstract: Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, n is an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH, or S.

Abstract: The loss of body/cranial hair is promoted and/or its growth is slowed/prevented by topically and/or systemically administering to an individual in need of such treatment respectively effective amounts at least one lipoxygenase inhibitor and at least one cyclooxygenase inhibitor, or alternatively, an effective amount of an active agent that is both a lipoxygenase inhibitor and a cyclooxygenase inhibitor.

Abstract: Dermatological/cosmetic compositions for reducing or decelerating human hair loss comprise an effective hair loss-reducing amount of combinatory immixture of (a) at least one antifungal agent and (b) at least one halogenated antibacterial agent other than a macrolide or pyranoside, characteristically formulated in a topically physiologically acceptable medium therefor.

Abstract: An invention is disclosed which comprises gelling agents which (1) contain both siloxane groups and hydrogen-bonding groups to thicken compositions containing silicone fluids (volatile and/or non-volatile silicone fluids); (2) are non-flowable solids at room temperature; and (3) dissolve in a fluid which contains silicone at a temperature of 25-250 degrees C to form a translucent or clear solution at a temperature in this range. Cosmetic compositions may be made by adding at least one active ingredient such as an antiperspirant.

Abstract: A composition comprising a 2-acetaminoalkane-1,3-diol or its optical isomer having the formula: ##STR1## wherein R.sub.1 represents a linear alkyl group having 9 to 17 carbon atoms; a 2-acylaminoalkane-1,3-diol or its optical isomer having the formula: ##STR2## wherein R.sub.1 has the same meaning as given above for formula (I) and R.sub.2 represents a substituted or unsubstituted linear acyl group having 14 to 24 carbon atoms; and a compound having a sterol group. This composition forms a lamellar liquid crystal phase and can retain moisture when applied to the skin.

Abstract: A strengthening agent for living creatures for the care of the skin and horny structures, in particular nails, hooves and claws, and for the stimulating and/or revitalizing of the growth of epidermal structures, in particular hair, this agent containing the alkaloid trigonelline or trigonellic acid, being obtained preferably from an extract of the seeds of a plant from the genus trigonella, in particular fenugreek (Trigonella foenum graecum), and being taken orally, characterized by the fact that the agent contains biotin, preferably 5 mg to 10 mg.

Abstract: The invention relates to a cosmetic or dermatological composition containing at least one active principle precursor capable of releasing an active principle by enzymatic reaction on contact with the Stratum corneum and at least one crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90% and to its uses. It generally contains, distributed randomly: (a) from 90 to 99.9% by weight of units of formula (1): ##STR1## in which X.sup.+ denotes a cation or a mixture of cations, it being possible for at most 10 mol % of the cations X.sup.+ to be protons H.sup.+ ; and (b) from 0.01 to 10% by weight of crosslinking units resulting from at least one monomer having at least two olefinic double bonds, the proportions by weight being defined with respect to the total weight of the polymer.

Abstract: The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.

Abstract: The present invention relates to a novel composition based on hydrated lipidic lamellar phase or on liposomes and to a cosmetic or pharmaceutical, particularly dermatological composition incorporating it. The hydrated lipidic lamellar phases or the liposomes contain at least in part a derivative of labdane, or a plant extract containing it. The invention reduces hair loss and promotes hair growth.

Abstract: Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, for stimulating melanogenesis, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise complexation of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II) salts and tin(IV) salts.

Abstract: Methods and compositions for the topical treatment of ectoparasites on animal skin utilizing a water-soluble or water-dispersible, substantially air-impermeable liquid composition.

Abstract: A silicone-containing phospholipid having the general formula: ##STR1## wherein: A is selected from H, M or R.sub.9 --Y--;A.sub.1 is selected from H, OH, OM or R.sub.9 --Y--O--;M is a cation;Y is alkylene;x is 0 or an integer from 1-5; andR.sub.9 is a mixture of a organosilicone carboxyl functional moiety of the formula: ##STR2## wherein: R.sub.10 is the silicone backbone chain to which at least one pyrrolidone containing carboxyl functional group is attached;F is linear or branched alkylene of 1-12 carbon atoms;X.sup.- is an anion;n is 0 or 2;n.sup.1 is 0 or 1;n.sup.2 is 0 or 1;B is --NR.sub.11 sulfur or oxygen, wherein R11 hydrogen or lower alkyl (C.sub.1-6); andd is one or greater;an organic amidoamine moiety and/or an organic tertiary amine moiety.

Abstract: Method for assessing the activity of a test substance as a K.sup.+ channel agonist or for mitogenic activity. Fibroblasts are cultured in a test medium which is free of aminoglycoside antibiotics, the medium is supplemented with serum or serum substitute and the test substance, and the response of the supplemented cells to the test substance is assessed.

Abstract: A novel method and delivery system for therapeutic weak acid or base materials has been developed. The method and delivery system utilize a therapeutic material which is modified to make it more hydrophilic and encapsulated in a lipid vesicle, preferably a non-phospholipid lipid vesicle. The method and delivery system is particularly well suited to topical delivery of minoxidil.

Abstract: The present invention deals with the composition of matter and the utilization of certain novel meadowfoam based betaine compounds. These materials are useful in personal care applications.

Abstract: The present invention deals with a process for cleaning and conditioning hair and skin which comprises the contacting of hair or skin woth an effective concentration of certain novel meadowfoam derived sulfosuccinates. These materials are useful as cosmetic ingredients as additives to shampoo systems where outstanding liquidity, resistance to oxidation, and minimal odor variation are required.

Abstract: Hair care preparation which promotes the growth of new hair, helps prevent dry, thinning hair and minimizes hair breakage and split ends. The preparation contains a combination of 10% to 40% of water, 1% to 10% of castor oil, and 50% to 90% of glycerin. These compositions are characterized by the fact that the glycerin acts as a hair penetrant, a carrier for the castor oil and the water, and provides shine and lubricates the hair sheath, the water moisturizes the hair sheath, and the castor oil nourishes and softens the hair.

Abstract: Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.