Abstract: The invention relates to an oil-in-water emulsion comprising, as an active ingredient, &agr;-tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a &agr;-tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischemia and /or reperfusion and, among other things, during an organ transplantation.

Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.

Abstract: Microemulsion gels a) based on water in oil type microemulsions, comprising an oil phase which is essentially composed of not easily volatile components, an aqueous phase containing one or more polyethoxylated W/O emulsifiers and/or one or more polypropoxylated W/O emulsifiers and/or one or more polyethoxylated and polypropoxylated W/O emulsifiers and/or one or more monoesters, diesters, polyesters of polyols as W/O emulsifiers and/or one or more monoethers, diethers, polyethers of polyols as W/O emulsifiers and/or one or more dimethicone copolyols as W/O emulsifiers and/or one or more fatty alcohols or fatty acids as W/O emulsifiers and/or one or more sorbitan esters as W/O emulsifiers and/or one or more methyl glucose esters as W/O emulsifiers, and also comprising if desired one or more O/W emulsifiers, obtained in such a way that a mixture of basic components comprising an aqueous phase, an oil phase, one or more inventive emulsifiers is produced, being the HLB value of the emulsifier or emulsifier combina

Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.

Abstract: A lip care moisturizing product in the form of a water-in-oil emulsion, containing at least one fatty acid ester, at least one wax, the total of said at least one fatty acid ester and said at least one wax being at least about 1.0%, liposomes containing water therein, and an emulsifier. The emulsifier is preferably a mixture of behenoyl stearate and sodium borate, and the liposomes preferably contain a mixture of water and glycerin.

Abstract: An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.

Abstract: A controlled release composition for a biologically active material, which composition is liquid or liquid crystalline and comprises at least one medium or long-chain fatty acid ester of diglycerol as a carrier for said biologically active material, said biologically active material being dissolved or dispersed in said carrier. Said composition is especially useful as a medical composition.

Abstract: Emulsions prepared using a silicone polyether as the surfactant are stable in an aqueous media in the presence of salts such as electrolytes, alcohols, solvents, and combinations thereof. The emulsions can be prepared by (i) polymerizing an unsaturated monomeric organic compound in water containing the monomer, a silicone polyether, a catalyst, and optional organic surfactants, until a polymer of desired molecular weight is obtained; (ii) by mechanically emulsifying a non-silicon atom containing organic oil in water using a silicone polyether with or without addition of other organic surfactants; and (iii) by mixing and adding a silicone polyether to a previously prepared emulsion.

Abstract: Topical analgesics, generally comprising calendula oil and cornmint oil, and methods of use.

Abstract: The present invention relates to a liquid dual phase cosmetic or pharmaceutical composition comprising an oil phase and an aqueous phase, the composition containing as a demixing agent a film forming agent such as polyvinylpyrrolidone and derivatives thereof. The compositions of the invention are particularly useful as makeup removers.

Abstract: The invention relates to a tanning preparation for the skin comprising at least one tyrosine derivative of formula 1, where R<1>=—H, —(CH2)x-CH3, x being an integer from 1 to 20, R<2>=CH3CO—, CH3—(CH2)yCO—, y being an integer from 1 to 20, and an activator consisting of an aliphatic polyol having at least 10 C atoms in the molecule. The aliphatic polyol preferably consists of a hexadecanetriol, in particular phytantriol. Expediently, the tanning preparation is a gel, lotion, cream, foam, spray or emulsion.

Abstract: A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes.

Abstract: The invention provides wet skin treatment compositions for use during bathing. The compositions are activated by water and retained efficiently on skin. The compositions impart desirable benefits to skin, are perceived to absorb quickly on wet skin, and leave the skin feeling clean, but non-greasy.

Abstract: Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.

Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.

Abstract: This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian subject a chemopreventive agent and analogs and metabolites thereof. The chemopreventive agent prevents, prevents recurrence of, suppresses or inhibit prostate carcinogenesis; and treats prostate cancer.

Abstract: Use of a polyamino polymer to inhibit the light-induced peroxidation of lipids, particularly inhibition of the photo-peroxidation of lipids induced by nanopigments. The invention also relates to the use of a polyamino polymer to inhibit the light-induced peroxidation of proteins. This property of polyamino polymers finds applications in particular in the cosmetics, pharmaceutical, veterinary and agrifood fields.

Abstract: A description is given of the use of a nanodispersion, which comprises

Abstract: A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.

Abstract: Cosmetic skin care methods comprising applying to the skin compositions containing gum mastic. The inventive compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.

Abstract: Lipsticks, antiacne sticks, sunscreen sticks and eyeshadow sticks, with a high water content, characterized in that they comprise (a) a lipid phase, which comprises (a1) at least one oil component (a2) at least one wax component (a3) optionally other substances soluble or dispersible in the lipid phase, (b) an aqueous phase, which comprises (b1) from 30 to 85% by weight of water, based on the total weight of the stick composition and (b2) if desired, substances soluble or dispersible in water, (c) at least one active ingredient or several chosen from the active ingredients known for lipsticks, antiacne sticks, sunscreen sticks and eyeshadow sticks, (d) a W/O emulsifier or a mixture of two or more W/O emulsifiers, (e) one or more stabilizers, chosen from the group of substances of the general structure A—B—A′, where A and A′ are identical or different hydrophobic organic radicals, and B is a hydrophilic group, (f) if desired, further surface-active substances as coemulsifiers

Abstract: A therapeutic composition comprising (i) at least one antigen or at least one in vivo generator of a compound comprising an amino acid sequence and (ii) at least one adjuvant comprising at least one pharmaceutically acceptable and water-soluble salt of an organic anion and a metal cation.

Abstract: This invention includes emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one hydrophilic biologically active molecule and, optionally, cholesteryl ester, and/or apoprotein; methods of preparing these emulsions; and the use of these emulsions for the delivery of hydrophilic biologically active molecules to cells.

Abstract: A preservative system comprising iodopropynyl butyl carbamate and phenoxyethanol at a weight ratio of iodopropynyl butyl carbamate to phenoxyethanol within the range of about 1:90 to about 1:400 shows a broad anti-microbial effect and can permit use of the preservative system at a low level in end use products such as personal care products.

Abstract: The present invention provides a more efficient method of delivering therapeutically effective amounts of ascorbic acid and acetone to the dermal layer of the skin via the topical application of 5,6-O-isopropylidene L-ascorbic acid. This invention further provides a stable, cosmetically acceptable vehicle in which the 5,6-O-isopropylidene L-ascorbic acid can be applied to the skin.

Abstract: A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.

Abstract: Cosmetic or dermatological preparations which are finely disperse systems of the water-in-oil type, comprising 1. an oil phase, 2. a water phase, 3. a combination of a) at least one modified phyllosilicate b) and boron nitride, where both the modified phyllosilicate or phyllosilicates and the boron nitride exhibit both hydrophilic and lipophilic properties, i.e. have amphiphilic character and position themselves at the water/oil interface and 4. at most 0.5% by weight of one or more emulsifiers and optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.

Abstract: The preset invention relates to a pharmaceutical cream composition for topical application for the treatment of skin disorders and skin diseases, comprising 1-6 wt. % Dead Sea Mud as an active ingredient. Said composition is for use in treating skin disorders and skin diseases such as psoriasis, saborrehic dermatitis, xerosis, attopic dermatitis, eczema, diaper rush, skin burns of stage I and sensitive skin. Said cream composition is also for use as a leave-on cosmetic cream for beautifying and enhancing the skin appearance. In addition to Dead Sea Mud said composition comprises ingredients suitable for the preparation of cosmetic cream. Said cream can further comprises up to 4 wt % Dead Sea water.

Abstract: A non-toxic aqueous pesticide and method are provided for controlling insects and parasites on plants. The pesticide contains at least one surfactant and at least on high terpene containing natural oil to effectively control insects and parasites, such as darkling beetles, lice, ticks, mites, flies, aphids, mosquitoes and chiggers. Further, the pesticide has a pH of about 7.7: to about 9.0. Also the pesticide is diluted with water at a dilution rate of from about 1:10 to about 1:600 by weight of the pesticide for application to a plant to control the insects and parasites.

Abstract: A concentrate package-mix composition comprising a water-soluble pesticide or plant growth regulator, for example a salt of the herbicide glyphosate, and a solid water-insoluble pesticide or plant growth regulator, for example the herbicide flumioxazin, is provided. The water-soluble pesticide or plant growth regulator is dissolved in a continuous aqueous phase of the composition and solid particles of the water-insoluble pesticide or plant growth regulator are suspended in the aqueous phase. These solid particles, individually or plurally, are intimately surrounded by a barrier layer, which comprises either one or both of a water-immiscible organic solvent or an emulsifying agent that has a hydrophile-lipophile balance (HLB) not greater than about 15. Optionally the composition further comprises a viscosity modifying agent, such as colloidal hydrophilic silica, dispersed in the aqueous phase.

Abstract: The present invention relates to a hair treatment preparation and a method of use thereof. The hair treatment preparation is in the form of an oil-in-water emulsion and is preferably used for reducing split ends. The hair treatment preparation contains a lipid soluble ester alcohol or ester polyol and a water-soluble compound selected from panthenol, a panthenol derivative, nicotinic acid amide, a sugar, polyvinyl pyrrolidine or mixtures thereof.

Abstract: A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a surfactant. The composition is stable and provides high absorption efficiency.

Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.

Abstract: Emulsifier-free cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water type, comprising 1. an oil phase, 2. an aqueous phase and 3. one or more types of micronized, inorganic pigments which a) have an average particle size of less than 200 nm, and whose particles b) have both hydrophilic and lipophilic properties, i.e. have an amphiphilic character, and thus position themselves at the water/oil interface, and which c) are selected from the group consisting of metal oxides, which d) are optionally coated on the surface and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.

Abstract: Stable, biocompatible cosmetic or dermatological oil-in-water emulsions (I), containing fatty acids and alcohols, glycerides, ethoxylated esters, non-polar lipids and consistency components, are new. Cosmetic or dermatological oil-in-water emulsion preparations (I) contain (by weight): (a) 0.1-5% 14-22 C fatty acid(s); (b) 0.2-10% fatty acid mono- and/or diglyceride(s); (c) 0.1-5% ethoxylated fatty acid ester(s); (d) 0.5-10% non-polar lipid(s); (e) 0.5-7.5% fatty alcohol(s); and (f) 0.5-7.5% lipophilic consistency source(s) having a melting point or drop point of at least 30 degrees C. The sum of the contents of (a)-(c) is at most 12% and the lipid phase optionally contains up to 40% (based on this phase) of polar lipids.

Abstract: The present invention relates to topical compositions for effecting an immediate improvement in the appearance and feel of skin, in addition to providing chronic improvements in skin appearance. The compositions comprise from 0.5% to 25% of a first particulate material having a refractive index of from 1.3 to 1.7, the particulate material being dispersed in the composition and having a median particle size of from 2 to 30 um, and an active effective for chronically regulating skin condition selected from Vitamin B3 compounds, retinoids, and mixtures thereof. Preferred emobodiments are oil in water emulsions further comprising a second particulate material having a larger particle size than the first.

Abstract: Cosmetic and dermatological preparations in the form of O/W emulsions, comprising (1) 0.1 up to 5% by weight, based on the total weight of the preparations, of one or more C14-C22-fatty acids, (2) 0.2 up to 10% by weight, based on the total weight of the preparations, of one or more mono- and/or diglycerides of fatty acids, (3) 0.1 up to 5% by weight, based on the total weight of the preparations, of one or more ethoxylated fatty acid esters, where the sum of (1), (2) and (3) is at most 12% by weight, (4) 0.5 to 10% by weight, based on the total weight of the preparations, of one or more nonpolar lipids, (5) 0.5-7.5% by weight, based on the total weight of the preparations, of one or more fatty alcohols (6) 0.5-7.5% by weight, based on the total weight of the preparations, of one or more lipophilic bodying agents having a melting point or dropping point of ≧30° C., (7) 0.

Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract: Cosmetic composition for topical application to the skin comprise a cyclodextrin compound and a salicylic acid or salicylic acid derivative, wherein the composition is in the form of a water-in-silicone emulsion having a continuous silicone oil-containing phase and a discontinuous aqueous phase. The compositions herein provide improved anti-acne/anti-inflammatory activity together with reduced skin irritation.

Abstract: An aqueous cosmetic phase-inversion temperature emulsion containing: (a) a wax ester; (b) a triglyceride; (c) a partial glyceride; and (d) a fatty alcohol polyglycol ether.

Abstract: This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure: wherein each X is halo; m is 1 to 4; each R′ and R″ is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

Abstract: An O/W medical fat emulsion for oral administration, which is capable of increasing the bioavailability of a medicine or the blood level thereof. The emulsion is composed of fat emulsion particles containing an oil component, an emulsifier and a medicine as the indispensable constituents and dispersed in water, characterized in that the average diameter of the particles in the fat emulsion ranges from 5 to 50 nm. A freeze-dried preparation of the emulsion is also included in the invention.

Abstract: There are provided topical compositions having reversible visible change in color in response to change in light. The compositions comprise color changing capability provided by photochromic material and a vehicle acceptable for topical application to the skin or hair.

Abstract: The present invention relates to an oil-in-water emulsion containing tretinoin and the use thereof in mitigating skin disorders such as acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin.

Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.

Abstract: The present invention relates to emulsions comprising an emulsification system comprising a mixture of at least one cationic surfactant, at least one anionic surfactant, at least one “bridging surfactant”, an oil and water, along with methods for preparing such emulsions. More specifically, the invention relates to stable, synergistic emulsions of various oils, water, cationic, anionic, and bridging surfactants that are useful in preparing a variety of finished personal care, laundry, and cleaning products, including for examples creams, lotions, sunscreens, liquid dish detergents, laundry detergents, automatic dishwasher detergents, hand soaps, laundry bars, personal cleansing bars, multi-purpose cleaners, multi-functional shampoos, body washes, and textile treatment compositions. The emulsifications of the present invention also may be employed in agricultural and pesticide applications. Additionally, the surfactant blends may be utilized in antimicrobial formulations (e.g.

Abstract: Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1—W—RH1  (I) wherein RF1 is a linear, branched or cyclic C2-14 fluorocarbon group; RH1 is a linear, branched or cyclic C2-18 saturated or unsaturated hydrocarbon group; and W is absent or is a bivalent species chosen from the group consisting of —O—, —S—, or various fluorinated structures. Use of the fluorophilic/lipophilic compound in the dispersions of the invention provides stable particle size and efficient emulsification. The dispersions of the invention can comprise biologically useful additive and can be used for various purposes, as oxygen carriers, contrast agents, or diagnostic agents.

Abstract: The invention relates to a stable fumagillin formulation and to the method of use thereof in treating and/or combating intestinal infections.

Abstract: There is provided a sunscreen emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has a sunscreen active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from overexposure to the sun in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a sunscreen emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free sunscreen composition.

Abstract: W/O or O/W stable dispersions are formed by mixing an oily phase and an aqueous phase when the dispersion is stabilized with cubic gel particles formed by the combination of two amphiphilic compounds, one of the amphiphilic compounds being capable of forming a lamellar phase in the presence of water, and the other being capable of forming an inverse hexagonal phase in the presence of water.