Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin malic acid.

Abstract: Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin 2-phenyllactic acid.

Abstract: Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

Abstract: Water-in-oil and water-n-oil-in-water multiple emulsions and methods of preparation employing polyoxyethylene polyoxypropylene block copolymers added to the inner aqueous phase during preparation of said emulsions. The emulsions are useful in numerous applications including, but not limited to, vaccine adjuvants, pharmaceuticals, cosmetics, foods, and various household and industrial uses.

Abstract: An oil-in-water type cream base containing a colloidal hydrous silicate and a polyethylene glycol having an average molecular weight of 1,000-10,000, and emulsified by means of a microfluidizer. Preferably, the cream base contains a crystalline cellulose. According to the present invention, the strong, safe and stable cream base having excellent sensuosity can be prepared without using a surface active agent which is not always safe for men.

Abstract: The invention relates to a stabilized, cosmetically and/or dermatologically acceptable emulsion intended to moisturize the skin. This emulsion contains a fatty phase, an aqueous phase, at least one emulsifying agent and at least one moisturizing agent. The aqueous phase contains at least one phosphated compound capable of releasing, via an enzymatic reaction when it is in contact with the skin, an active agent other than the moisturizing agent, which promotes moisturization of the skin, and the fatty phase contains at least one silicone-containing gum and/or one perfluoro oil. The emulsion according to the invention makes it possible to combat ageing of the skin, acne, pigmentation of the skin and/or hair loss.

Abstract: Disclosed is a stable water-in-oil emulsion system formed of an organopolysiloxane elastomer, a vehicle in which the elastomer is dispersed or dispersible, a stabilizing agent, a surfactant and an aqueous component and a process for forming the stable water-in-oil emulsion. The stabilized water-in-oil emulsion is useful in personal care products.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising nanoparticles of a barium salt having associated with its surface non-ionic and anionic stabilizers; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: A homogeneous, essentially nonaqueous adjuvant composition containing at least one spray oil selected from the group consisting of(a) vegetable oils;(b) fatty acids and blends thereof;(c) esterified fatty acids or blends thereof;(d) saponified fatty acids or blends thereof;(e) N,N-dimethylamide of the formulaRCON(CH.sub.3).sub.2(f) polybutenes of the following formula ##STR1## a surfactant in an effective amount to emulsify said composition and a buffering agent in amount sufficient to reduce the pH to below about 7.

Abstract: A topical bioadhesive ointment composition comprising an aqueous mineral oil emulsion which is readily spread able and film-forming, and, upon application to moist skin or a mucosal surface, forms a stable, coherent layer thereon which resists removal therefrom by water or a body fluid associated with the mucosal surface to which the ointment composition is applied is disclosed. Also disclosed are pharmaceutical compositions containing the ointment compositions and a pharmaceutically active agent, e.g. , TGF.alpha.; and methods of using and methods of preparing the compositions.

Abstract: An aqueous cosmetic or dermo-pharmaceutical composition contains, in suspension in the continuous phase, hydrated spheroids of a hydrophilic lipidic substance. The hydrated spheroids have an average particle diameter ranging from 50 to 10,000 .mu.m. A process for the preparation of this composition is described.

Abstract: This invention relates to physiologically acceptable emulsions of perfluorocarbon ether hydrides having 8 to 12 carbon atoms. These novel emulsions have various medical applications. They are especially useful medically as contrast media for various biological imaging modalities such as nuclear magnetic resonance, .sup.19 F-magnetic resonance imaging, ultrasound, x-ray, and computed tomography, as oxygen transport agents or "artificial bloods" in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.

Abstract: The solubilization of salicylic acid derivatives, and in particular of 5-n-octanoylsalicylic acid, is achieved by mixing the salicylic acid derivative with a vegetable oil. The obtained compositions are useful, in particular, for treating acne and ageing.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a barium salt in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: This application relates to an aqueous formulation of fenbendazole which is stable and efficacious, does not agglomerate upon standing and wherein the fenbendazole remains in suspension after standing for twenty-four hours.

Abstract: An aqueous cosmetic or dermo-pharmaceutical composition contains, in suspension in the continuous phase, hydrated spheroids of a hydrophilic lipidic substance. The hydrated spheroids have an average particle diameter ranging from 50 to 10,000 .mu.m. A process for the preparation of this composition is described.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier comprising a cellulose derivative.

Abstract: The present invention relates to gelled emulsion particles obtained when predetermined volumes, especially drops, of an emulsion with an aqueous external phase, containing an appropriate reagent in solution in the said aqueous phase, are added to a gelling solution and left therein for a period of time which depends on the degree of gelling desired for the said particles.It further relates to compositions--especially solutions, gels or emulsions with an aqueous external phase--in which the said particles are present.

Abstract: This invention relates to physiologically acceptable emulsions of perfluorocarbon ether hydrides having 8 to 12 carbon atoms. These novel emulsions have various medical applications. They are especially useful medically as contrast media for various biological imaging modalities such as nuclear magnetic resonance, .sup.19 F-magnetic resonance imaging, ultrasound, x-ray, and computed tomography, as oxygen transport agents or "artificial bloods" in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.

Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.

Abstract: High impact energy is applied to a modified lecithin in water, to form a base product. A block copolymer surfactant, water and organic oil are added to this base product, and high impact energy is applied once again. The resultant product is a stable aqueous distribution of the organic oil.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodobenzoic acid derivatives as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: The invention relates to a novel process for the preparation of stable complex multiple emulsions of the water-oil-water type which are well suited for use in cosmetic preparations. The primary emulsions of the W/O type are prepared in the presence of both a non-ionic polymeric lipophilic emulsifier and a non-ionic polymeric stabiliser each preferably having an HLB value in the range from 6 to 10. In a second process step more water containing a hydrophilic emulsifier having a higher HLB value, preferably in the range from 12 to 25, is added to the primary emulsion until phase inversion occurs. It is important that the procedure in this second process step is not reversed, i.e. that the primary emulsion is not added to the aqueous phase. Further active substances, such as UV filters and vitamins, may be added to the aqueous or oil phase respectively.

Abstract: The invention relates to a cosmetic composition containing in a cosmetically acceptable medium at least one nonionic surface-active agent of the family of alkyl polyglycosides and/or a polyglycerolated nonionic surface-active agent and at least one polyetherurethane, as well as a process for cosmetic treatment consisting in applying to the skin or the hair a cosmetically effective amount of this composition.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: A pharmaceutical composition is disclosed in the form of a nonirritating emulsion which includes at least one cyclosporin in admixture with a higher fatty acid glyceride and polysorbate 80. More particularly, the cyclosporin may be cyclosporin A and the higher fatty acid glyceride may be castor oil. Composition has been found to be of a high comfort level and low irritation potential suitable for delivery of medications to sensitive areas such as ocular tissues. In addition, the composition has stability for up to nine months without crystallization of cyclosporin.

Abstract: Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and are not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: Microemulsions of water-insoluble active ingredients, employing a special surfactant system and solvent system. These microemulsions remain thermodynamically stable over a wide range of water dilutions.

Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.

Abstract: What is provided herein is a stable, emulsifiable gel matrix for an agriculturally active chemical, which matrix will form an emulsifiable gel concentrate upon addition of the agriculturally active chemical, and upon water dilution, a highly stable aqueous macroemulsion which avoids precipitation of the active ingredient on extended storage. In addition, the inventive emulsifiable gel concentrates may contain relatively high concentrations of the agriculturally active chemical, the concentration sometimes referred herein to as "loading", making it advantageous from both the economic and handling viewpoints.

Abstract: Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.

Abstract: A method of treating wood and timber is disclosed. Wood or timber is treated with a pesticidal microemulsion or other water-miscible formulation that has an average particle size of at most 200 nm. The treatment is particularly effective in protecting wood and timber against the common furniture beetle (Anobium punctatum), the house longhorn (Hylotrupes bajulus), the death watch beetle (Xestobium rufovillorum), dry rot (Serpula (merulius) lacrymans) and wet rot (Coniophora puteena).

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and a nonionic x-ray producing agent in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: A homogenous, essentially nonaqueous adjuvant composition comprising a spray oil and a surfactant blend selected from the group consisting of sorbitan fatty acid ester, polyethoxylated derivative of a sorbitan fatty acid ester, fatty alkanolamides, peg esters, silicone surfactants, ethoxylated fatty acids, alkyl ethoxylates, alkylphenol ethoxylates, polypropylene glycols, and amine ethoxylates and a buffering agent selected from the group consisting of alkylaryl polyethoxy phosphate ester, C.sub.1 -C.sub.6 carboxylic acids, C.sub.1 -C.sub.6 dicarboxylic acids, phosphoric acid, citric acid, glutaric acid, gluconic acid, lactic acid, glycolic acid, acrylic acid, carboxylated alcohol ethoxylateR--O (CH.sub.2 CH.sub.2 O).times.HR=C-C.sub.25 carboxylic acid, andX=1-20 moles ethylene oxide in an amount sufficient to reduce the pH to below 7.

Abstract: A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement medium capable of facilitating the detection of tumors and other elements within the body. This emulsion is stable and maintains its very small particle size characteristics for extended periods of time, often exceeding eighteen months after sterilization, and further may include a stabilizing component selected from the group consisting of steroids, tocopherols, cholesterols, and combinations thereof. An anti-oxidizing component enhances delivery in oxygen transport.

Abstract: A liquid or pasty, storage-stable, multiple emulsion of the O.sup.1 /W/O.sup.2 type, in which O.sup.2 forms an outer phase of the multiple emulsion, a hydrophilic emulsifier being present at the O.sup.1 /W interface and a hydrophobic emulsifier being present at the W/O.sup.2 interface, is prepared where(1) the hydrophobic emulsifier has an HLB value of at most 8 anda.sub.1) a polyacrylate ester with long-chain hydrocarbon and polyoxyalkylene groups, ora.sub.2) a polyoxyalkylenepolysiloxane with long-chain alkyl groups linked to silicon atoms, and(2) the hydrophilic emulsifier is a nonionic emulsifier with an HLB value of more than 8.

Abstract: This invention relates to an improved skin care composition for moisturizing and conditioning the skin. In particular, it relates to a cosmetically acceptable, translucent skin conditioning lotion having an emulsified petrolatum base. The emulsions of the present invention are prepared using a crosslinked organopolysiloxane-polyoxyalkylene emulsifier and involve matching the refractive indices for the continuous and discontinuous phases.

Abstract: The present invention relates to a process for the preparation of stable oil in water emulsions which comprises (a) mixing an oil with effective emulsifying concentration of a silicone based phosphate ester (b) subsequently adding water and in a final step (c) homogenizing the resulting mixture to obtain an surprisingly stable emulsion.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline contrast agent in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: A water-in-oil type emulsified solid composition containing (a) an oil component such as a silicone oil, (b) a solid wax and/or an oil-gelling agent, (c) water, and (d) (i) a polyoxyalkylene modified organopolysiloxane or (ii) a lipophilic surfactant and a hydrophobically treated powder, wherein the water content is 5% by weight or more, based upon the total amount of the composition.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline organic constrast agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and a barium salt in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; andX is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.

Abstract: Stable pyrethroid microemulsion compositions having from 0.1% to 95% by weight/weight of at least one pyrethroid in liquid form; from 2% to 90% by weight/weight of a three-component surfactant system having at least one anionic surfactant, at least one nonionic surfactant and at least one co-surfactant chosen from aliphatic alcohols, cycloaliphatic alcohols, arylaliphatic alcohols, ether-alcohols and aliphatic carboxylic acids; and water.The ratio by weight of anionic surfactant/nonionic surfactant is from 10/90 to 90/10, and the ratio by weight of co-surfactant/anionic and nonionic surfactants is from 0.1 to 1.5.The microemulsion compositions are applied directly or after dilution with water to plants (crops) or wood for controlling insects.

Abstract: Stable diphase emulsions consisting of:a) perfluoropolyethers having perfluoroalkyl end groups;b) a conventional surfactant, dispersed inc) a continuous dispersing phase consisting of glycerol or of a polyhydroxylated compound containing at least three hydroxyl groups, selected from polyalcohols and saccharides, dissolved in a hydrophile solvent and/or water.