Ointment Or Salve Base Patents (Class 514/969)
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Patent number: 6004558Abstract: The present invention relates to the preparation of therapeutic compositions comprising extracts of leguminous plants from which the isoflavones genistein, daidzein, formononetin and biochanin and/or their glycosides have been removed. The invention also relates to therapeutic uses of such extracts in the treatment, prophylaxis, amelioration of, or defense against a variety of cancers.Type: GrantFiled: February 25, 1998Date of Patent: December 21, 1999Assignee: Novogen, Inc.Inventors: Michael Joseph Thurn, Li Jiu Huang
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Patent number: 5997876Abstract: This invention refers to the sphere of medicine, in particular to pharmaceutics and concerns the preparations for burn treatment. The technical result of the present invention is in widening the assortment of medicinal preparations for treatment of bums and wounds, in increasing treatment effect. The ointment contains the components in the following relation of mass parts:______________________________________ celandine Chelidonium majus 15-25 g plantain Plantago major 15-25 g matricary Matricaria chamomilla 15-25 g yarrow Achillea millefolium 15-25 g calendula Calendula officinalis 15-25 g St.Type: GrantFiled: November 10, 1998Date of Patent: December 7, 1999Inventors: Nino Shikhashvili, Zurab Darsavelidze
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Patent number: 5989559Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 29, 1998Date of Patent: November 23, 1999Assignee: Delft Pharma InternationalInventor: Bobby Gene Edwards
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Patent number: 5981605Abstract: Gel for local treatment of skin diseases and for prophylaxis, characterised by containing more than 90% of a drying and/or protein coagulating, short-chained alcohol or alcohol mixture, primarily ethanol, and possibly adjuvants or additives and by containing a gelling agent, that possesses good skin-adhesive properties, that gives a matrix formation of alcohol or alcohol mixtures, that creates an evaporation-inhibiting effect, gives a prolonged effect, and forms a protective plaster when the gel has dried.Type: GrantFiled: October 29, 1996Date of Patent: November 9, 1999Assignee: John Brown ThomsenInventors: John Brown Thomsen, Jens Christian M.o slashed.ller
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Patent number: 5981497Abstract: This invention relates to a new use of a sophorolipidic compound, of pharmaceutically acceptable salts of the acidic form of the sophorolipid, and of the ester of the deacetylated sophorolipidic acid form as therapeutically active substances in a method for therapeutic treatment of the human or animal body, and more particularly as an activator of macrophages, as a fibrinolytic agent, as a healing agent, as a desquamating agent, and as a depigmenting agent.Type: GrantFiled: December 29, 1997Date of Patent: November 9, 1999Assignee: Institut Francais du PetroleInventor: Martine Maingault
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Patent number: 5972344Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 14, 1999Date of Patent: October 26, 1999Inventor: Bobby Gene Edwards
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Patent number: 5972327Abstract: A method for treating allergic rhinitis in a patient is disclosed which comprises applying an anti-allergic rhinitis effective amount of a steroid in ointment or creme carrier to the lining of the vestibules of the patient.Type: GrantFiled: October 22, 1997Date of Patent: October 26, 1999Inventors: Matthew M. Lin, Audrey H. Lin
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Patent number: 5958418Abstract: The present invention relates to a natural herbal composition of effective amounts of Aloe Vera, Capsicum, Golden Seal, Comfrey Root and water, to its method of use for external application to affected parts of the body for eliminating muscular pain and to its method of preparation.Type: GrantFiled: January 22, 1997Date of Patent: September 28, 1999Inventor: Kathleen O. Johnson Prillerman
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Patent number: 5958874Abstract: The invention provides an extracellular matrix for enhancing wound healing. The extracellular matrix comprises a recombinant fibronectin protein and a backbone matrix, wherein the recombinant fibronectin protein comprises peptides from two or more fibronectin domains. The extracellular matrix facilitates wound healing by providing hemostasis and, in addition, an environment that intrinsically recruits new tissue cells to the wound site. The extracellular matrix according to the subject invention is thus used in a method for enhancing wound healing. The method comprises applying the extracellular matrix to the wound.Type: GrantFiled: February 18, 1998Date of Patent: September 28, 1999Assignee: The Research Foundation of State University of New YorkInventors: Richard A. Clark, Doris Greiling, James Gailit
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Patent number: 5939083Abstract: Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow particulates effective to avoid the greasy and/or sticky feel otherwise attributable to the at least one fatty substance, said deformable hollow particulates comprising a copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylic comonomer and having a particle size ranging from 1 .mu.m to 250 .mu.m.Type: GrantFiled: June 9, 1997Date of Patent: August 17, 1999Assignee: Centre International de Recherches Dermatologiques GaldermaInventors: Josiane Allec, Eve Ferrara, Isabelle Bara
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Patent number: 5932230Abstract: An analgesic cosmetic formulation in the form of an ointment, salve or cream which is applied to the skin, including the hands and feet for the treatment of such conditions as redness, swelling, itching and soreness of the skin. The cosmetic formulation contains ingredients including oranges, avocado, watermelon, banana, lemon, palm oil, coconut oil, petroleum jelly, beeswax, aloe vera, vitamin E, aspirin, ammonium sulfate, sodium bisulfate and quine sulfate.Type: GrantFiled: October 28, 1997Date of Patent: August 3, 1999Inventor: Frenchell DeGrate
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Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds
Patent number: 5925376Abstract: An improved method of treating psoriasis involves controlling the enhanced proliferation and terminal differentiation of psoriatic epidermis through the activity of epidermal phosphorylase kinase. In general, the method involves contacting psoriatic epidermal cells with a combination of substances affecting the activity of phosphorylase kinase. The combination can be: (1) a calmodulin inhibitor together with a stimulator of cAMP-dependent protein kinase II, (2) a calmodulin inhibitor together with a calcium channel blocker; (3) a stimulator of cAMP-dependent protein kinase II together with a calcium channel blocker; or (4) a calmodulin inhibitor together with a calcium channel blocker and a stimulator of cAMP-dependent protein kinase II. Alternatively, a selective phosphorylase kinase inhibitor such as curcumin can be administered, alone or with an agent such as vitamin D.sub.3 or an analogue thereof, etretinate, diltiazem, or anthralin. The invention also includes pharmaceutical compositions.Type: GrantFiled: August 24, 1995Date of Patent: July 20, 1999Inventor: Madalene C. Y. Heng -
Patent number: 5919830Abstract: A stable non-aqueous carrier for personal care compositions comprising:a) about 80-98% by weight of a liquid polyoxyalkylene glycol of MW=3000-100000;b) about 2-20% by weight of a non-ionic solid triblock EO/PO/EO copolymer of MW=8500-25,000.Type: GrantFiled: April 30, 1998Date of Patent: July 6, 1999Inventors: Sridhar Gopalkrishnan, Richard J. Holland, Kathleen M. Guiney
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Patent number: 5919438Abstract: Dermatological/cosmetic compositions for reducing or decelerating human hair loss comprise an effective hair loss-reducing amount of combinatory immixture of (a) at least one antifungal agent and (b) at least one halogenated antibacterial agent other than a macrolide or pyranoside, characteristically formulated in a topically physiologically acceptable medium therefor.Type: GrantFiled: April 15, 1997Date of Patent: July 6, 1999Assignee: Societe L'Oreal S.A.Inventor: Didier Saint-Leger
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Patent number: 5902805Abstract: A method for the treatment of acne and/or the effects of ageing, by administering, to a subject in need thereof, a composition containing an effective amount of at least one HMG-Coenzyme A-reductase inhibitor in a carrier that is selected from the group consisting of dermatologically acceptable carriers, cosmetically acceptable carriers, and mixtures thereof, and the compositions for performing the method are provided.Type: GrantFiled: November 19, 1997Date of Patent: May 11, 1999Assignee: L'OrealInventors: Lionel Breton, Olivier De Lacharriere
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Patent number: 5895660Abstract: A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.Type: GrantFiled: August 15, 1996Date of Patent: April 20, 1999Assignee: LTS Lohmann Therapie-Systeme GmbHInventors: Hans-Rainer Hoffmann, Thomas Hille, Andreas Koch, Rudolf Matusch
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Patent number: 5885565Abstract: A method for enhancing penetration of a therapeutic or prophylactic agent in a host in need of the topical administration thereof which comprises applying to the epithelium of the host, an effective amount of one or more penetration enhancing epithelial sterols and the therapeutic or prophylactic agent.Type: GrantFiled: April 26, 1996Date of Patent: March 23, 1999Assignees: Cellegy Pharmaceuticals Inc., The Regents of the University of CaliforniaInventors: Peter M. Elias, Stephen Grayson, Carl R. Thornfeldt
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Patent number: 5882663Abstract: A method for providing pain relief includes topically applying to skin tissue an effective amount of higher homologs of isoparaffins, ranging from about C.sub.12 to C.sub.18. Compositions of the present invention include, with the isoparaffins in a mixture, at least one from the group consisting of salicylate, capsaicin, camphor, and menthol. Other constituents may be added for form creams or lotions.Type: GrantFiled: June 2, 1997Date of Patent: March 16, 1999Inventors: Erich A. Koeniger, Drahoslay Lim
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Patent number: 5882639Abstract: A method for treating photodermatitis, thermal burn, decubitus ulcer, or herpes zoster by topically applying a composition comprising a water soluble vinyl polymer gel or lotion comprising 1H-imidazole-4-ethanamine, phosphate uniformly mixed therewith to the affected areas.Type: GrantFiled: February 9, 1998Date of Patent: March 16, 1999Assignee: Professional Pharmaceutical, Inc.Inventors: Bruce A. Jack, B. Thomas White
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Patent number: 5879688Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.Type: GrantFiled: October 30, 1996Date of Patent: March 9, 1999Assignee: Focal, Inc.Inventors: Arthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
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Patent number: 5874095Abstract: The invention involves pharmaceutical compositions for topical application comprising:(a) a safe and effective amount of a pharmaceutical active; and(b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular wight of from about 1,000,000 to about 30,000,000.Type: GrantFiled: March 27, 1998Date of Patent: February 23, 1999Assignee: Richardson-Vicks Inc.Inventors: George Endel Deckner, Brian Scott Lombardo
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Patent number: 5869088Abstract: A transdermal administration preparation containing a 9-aminocyclopenta(b)quinoline, preferably 9-amino-2, 3,5,6,7,8-hexahydro-1H-cyclopentane(b)quinoline or its hydrochloride, as an active ingredient and the following transdermal absorption enhancer, that is, at least one compound selected from the group consisting of fatty acids, fatty acid esters, and alcohols, preferably the glyceride of a saturated fatty acid having 6 to 12 carbon atoms.Type: GrantFiled: April 17, 1997Date of Patent: February 9, 1999Assignee: Nikken Chemicals Co., LtdInventors: Yuko Hosokawa, Mutsuo Okumura, Mitsuru Ochiai
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Patent number: 5869087Abstract: A preparation for external use in application to the body, which comprises an antiphlogistic with carboxylic groups in the molecule, l-menthol and a metal salt of a fatty acid; and a patch having the preparation spread thereon for easier application to the body.Type: GrantFiled: February 27, 1997Date of Patent: February 9, 1999Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Munehiko Hirano, Kiyomi Tsuruta
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Patent number: 5856364Abstract: This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic antiviral-wound healing compositions for reducing viral titers and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.Type: GrantFiled: March 29, 1995Date of Patent: January 5, 1999Assignee: Warner Lambert CompanyInventor: Alain Martin
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Patent number: 5853732Abstract: The present invention provides pharmaceutical compositions comprising an effective amount of dermopharmaceutical active agent, kukui nut oil and a pharmaceutically acceptable base which comprises ingredients selected from the group consisting of propylene glycol, glycerin, xanthin gum, methyl paraben, propyl paraben, stearic acid, menthyl lactate, cetearyl alcohol (and) ceteareth 20, polyoxyl 40 stearate, glyceryl stearate (and) PEG-100 stearate, isopropyl myristate, isopropyl alcohol, oleyl alcohol, oleic acid, dimethicone, or C.sub.12 -C.sub.15 alcohols benzoate and purified water.The inclusion of kukui nut oil acts in synergy as an adjunct to the therapeutic agent to promote the alleviation of the medical condition being treated.Type: GrantFiled: October 27, 1997Date of Patent: December 29, 1998Assignee: Pharmacia & Upjohn CompanyInventor: James W. Munden
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Patent number: 5837735Abstract: An antiinflammatory agent for external use, containing nimesulide as the active ingredient dispersed in the base component and being well absorbable, safe and discoloration-free.Type: GrantFiled: July 10, 1997Date of Patent: November 17, 1998Assignee: Helsinn Healthcare S.A.Inventors: Satoru Miyata, Yasuaki Taniguchi, Kenji Masuda, Yoichi Kawamura
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Patent number: 5807957Abstract: A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I)R--(CO).sub.m Y.sup.1 --(CH.sub.2 CHR.sup.1 O).sub.n --?CONH--Z--NHCO(OCH.sub.2 CHR.sup.2).sub.n' --Y.sup.2 --(CH.sub.2 CHR.sup.2 O).sub.n" !.sub.p --CONH--Z--NHCO--(OCH.sub.2 CHR.sup.1).sub.n --Y.sup.1 (CO).sub.m R (I)where R represents (i) an alkyl, alkenyl or alkaryl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group or polybutylene oxide group; R.sup.1 and R.sup.2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; when m=0, Y.sup.1 represents O, NR.sup.3 or N.sup.+ R.sup.3 R.sup.4 X.sup.- and when m=1 Y.sup.1 represents O; Y.sup.2 represents O, NR.sup.3, N.sup.+ R.sup.3 R.sup.4 X.sup.-, (R.sup.3 NCH.sub.2 CH.sub.2).sub.t, or ?(R.sup.3 R.sup.4 N.sup.+ CH.sub.2 CH.sub.2)X.sup.- !.sub.t ; R.sup.3 and R.sup.4, independently, represent C.sub.1 -C.sub.Type: GrantFiled: December 23, 1996Date of Patent: September 15, 1998Assignee: MacroChem CorporationInventors: Carlos M. Samour, Scott F. Krauser
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Patent number: 5770582Abstract: The invention relates to compositions comprising 2'-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial burns induced by heat, sunlight, chemical agents, or infections, and methods for ameliorating the effects of aging of the epidermal tissues comprising administering the compositions of the present invention to an animal.Type: GrantFiled: April 10, 1995Date of Patent: June 23, 1998Assignee: Pro-Neuron, Inc.Inventors: Reid Warren von Borstel, Michael Kevin Bamat
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Patent number: 5766614Abstract: A new Burn Treatment Composition which provides healing to the skin of people who have received burns or are afflicted with other skin complications that require healing. The inventive device includes effective amounts of Chinese rhubarb; calcium hydroxide; sanguisorba officinalis rhizome; common camphor; coptis chinensis rhizome; phellodendron amurense bark and oldenlandia diffusa roxd.Type: GrantFiled: March 20, 1997Date of Patent: June 16, 1998Inventor: Liu Yong
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Patent number: 5756116Abstract: Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for using the topical compositions in treatment of herpes disease.Type: GrantFiled: December 2, 1996Date of Patent: May 26, 1998Inventor: Karl Y. Hostetler
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Patent number: 5750141Abstract: A vaso-active agent is administered in combination with a therapeutic agent which is useful in treatment of tissue of the body which is located below the stratum corneum or the outermost layer of the epidermis, wherein the vaso-active agent may be administered by a local, topical or transdermal route to a particular site and the therapeutic agent may be administered in a similar manner in combination with the vaso-active agent or may be administered separately, wherein the vaso-active agent and the therapeutic agent for topical and/or transdermal administration may be provided in the form of a composition so as to increase local perfusion and/or concentration of the therapeutic agent at or adjacent an administration site of the vaso-active agent.Type: GrantFiled: December 4, 1995Date of Patent: May 12, 1998Assignee: The University of QueenslandInventors: Michael Stephen Roberts, Sheree Elizabeth Cross, Parminder Singh
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Patent number: 5741509Abstract: A wound dressing is provided which comprises a blend of silicone fluid and fumed silica having the consistency of a stiff cream prepared in the presence of a volatile diluent that reduces the consistency of the silicon fluid-fumed silica blend to that of a spreadable cream or grease which can applied to a wound without producing further injury or undue discomfort. After the blend is in place on the wound, evaporation of the volatile diluent restores the consistency of the silicone fluid silica blend to its undiluted state, thereby allowing the advantages of increased wound adhesion and "smear proofing" to be achieved without producing further damage to the wound or undue pain and discomfort during application. The consistency of any particular blend of silicone fluid and fumed silica may be adjusted by varying the quantity of volatile diluent, thereby allowing the physician to vary the thickness of the film to help control the loss of water from the protected area.Type: GrantFiled: August 26, 1996Date of Patent: April 21, 1998Assignee: Alvin S. BerlatInventor: Jack Kushner
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Patent number: 5730992Abstract: An inhibitor of cholesterol synthesis is used for the treatment, alleviation or prevention of skin disorders.Type: GrantFiled: March 13, 1996Date of Patent: March 24, 1998Assignee: Ramot University Authority for Applied Research and Industrial Development, Ltd.Inventors: Naphtali Savion, Sara Brenner
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Patent number: 5728391Abstract: An agent for treating a skin disease selected from the group consisting of a contact dermatitis treating agent, a xerosis senilis treating agent, an asteatosis treating agent, a housewives eczema treating agent, a keratosis treating agent, an eczema chronicum treating agent, a miliaria treating agent and a diaper rash treating agent, which contains hyaluronic acid and/or its salt having an average molecular weight of from 800,000 to 4,000,000, as an active ingredient.Type: GrantFiled: December 5, 1995Date of Patent: March 17, 1998Assignee: Denki Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Ikeya, Hironoshin Kitagawa
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Patent number: 5725874Abstract: Percutaneously absorbable preparations which comprise, by weight, 0.001 to 20%, preferably 0.1 to 20%, of 3-l-menthoxy-propane-1,2-diol as a solubilizer for a drug and 0.001 to 20%, preferably 0.5 to 10%, of the drug as two essential ingredients, the balance being other ingredients as adjuvants selected from water-soluble polymers, monohydric alcohols, polyhydric alcohols, rosin esters, water, fatty acid esters, hydrocarbons, softening agents, emulsifying agents. The preparations are in the forms of poultice, plasters, ointments, gels, creams, gel-like creams, lotions, reserver patches, liniments, aerosols and may be used in packs.Type: GrantFiled: November 16, 1995Date of Patent: March 10, 1998Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hideshi Oda, Tetsuro Tateishi, Akira Nakagawa, Munehiko Hirano, Koki Shoho
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Patent number: 5716610Abstract: A pharmaceutical composition of water, water soluble vinyl polymer gel, amine alcohol dispersant and IEP is used topically to treat herpes labialis and aphthous stomatitis lesions, and also to treat herpes genitalis, chicken pox, allergic conjunctivitis, giant papillary conjunctivitis, stomatitis secondary to chemotherapy, thermal burn, sunburn, decubitus ulcers and shingles.Type: GrantFiled: August 2, 1996Date of Patent: February 10, 1998Assignee: Professional Pharmaceutical, Inc.Inventors: Bruce A. Jack, B. Thomas White
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Patent number: 5714165Abstract: A therapeutic composition having wet adherent properties and particularly useful for delivery of medicaments to mucosal surfaces comprises a therapeutically effective amount of a medicament dispersed in a base material comprising from about 3 to 15% by weight of a water soluble salt of a copolymer of methyl vinyl ether and maleic acid or anhydride and from about 85 to 97% by weight of polyethylene glycol. Formulations of the base material with triamcinolone acetonide and lidocaine are particularly efficacious in the treatment of recurrent aphthous ulcers.Type: GrantFiled: April 1, 1992Date of Patent: February 3, 1998Assignee: Mikkur, Inc.Inventors: Michael A. Repka, Thomas G. Gerding
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Patent number: 5709878Abstract: Disclosed is a novel transdermal delivery system for dehydroepiandrosterone (DHEA). Using phospholipids as vehicles, DHEA can be administered into and through the skin when topically applied. Numerous advantages apply to this modality of therapy.Type: GrantFiled: August 2, 1996Date of Patent: January 20, 1998Inventors: Jerry Rosenbaum, George Suarez
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Patent number: 5709868Abstract: In a method for the prevention and/or treatment of skin damage, particularly inflammation and aging, a composition containing lipoic acid and/or a lipoic acid derivative is topically applied to affected skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate and/or tocotrienol is preferably applied with the lipoic acid or derivative in association with a dermatologically acceptable carrier.Type: GrantFiled: September 20, 1995Date of Patent: January 20, 1998Inventor: Nicholas V. Perricone
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Patent number: 5688522Abstract: Wound healing compositions comprise from 1 to 20% by weight of a gel forming polysaccharide such as carboxymethyl cellulose and from 15 to 50% by weight of hexylene glycol. Such compositions are strongly antimicrobial, but show low toxicity to fibroblasts.Type: GrantFiled: August 13, 1996Date of Patent: November 18, 1997Assignee: Johnson & Johnson Medical, Inc.Inventor: Craig J. Hardy
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Patent number: 5686102Abstract: The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100% weight/volume, in a pharmaceutical excipient which is suitable for topical administration.Type: GrantFiled: July 3, 1996Date of Patent: November 11, 1997Assignee: Lancaster Group AGInventors: Udo Gross, Joachim Roding, Klaus Stanzl, Leonhard Zastrow
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Patent number: 5686100Abstract: Methods and devices for preventing and/or treating an adverse reaction of the skin to the presence of a skin-sensitizing and/or skin-irritating agent by administering an effective amount of a loop diuretic alone or in combination with at least one mast cell degranulator or at least one glucocorticosteroid.Type: GrantFiled: October 19, 1995Date of Patent: November 11, 1997Assignee: E.R. Squibb & Sons, Inc.Inventors: John J. Wille, Agis Kydonieus
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Water-soluble magnesium salts in externally applicable formulations and new combination preparations
Patent number: 5679359Abstract: Water-soluble magnesium salts in preparations for an external application are suitable to weaken UV-induced damages to the skin, especially premature aging of the skin and the formation of skin cancer. The effect is enhanced by a combination with vitamin E and/or vitamin E esters.Type: GrantFiled: January 4, 1996Date of Patent: October 21, 1997Assignee: Wogepharm GmbHInventor: Wolfgang Diezel -
Patent number: 5674481Abstract: This is a product and method for restricting the flow of airborne contaminants into a nasal passage. It involves creating an electrostatic field in an area near a nasal passage. The electrostatic field may either repel or attract airborne contaminants or both. The product may take the form of a plurality of masses of one or more electrostatic materials, the masses have an average cross sectional area of about one square millimeter to about 50,000 square millimeters, the mass being of sufficient charge to create an electrostatic field which will prevent at least some airborne contaminants from passing into a nasal passage. There is also a carrier material with the plurality of masses dispersed therein. The product may be a topical solution, a semi solid, a solid, a spray solution or a vaporizable solution. Alternatively, it may be in a form which includes a substrate for the carrier and, in one preferred embodiment, the substrate would be an adhesive material such as a bandage.Type: GrantFiled: November 20, 1995Date of Patent: October 7, 1997Inventor: Ashok L. Wahi
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Patent number: 5660839Abstract: Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow particulates effective to avoid the greasy and/or sticky feel otherwise attributable to the at least one fatty substance, said deformable hollow particulates comprising a copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylic comonomer and having a particle size ranging from 1 .mu.m to 250 .mu.m.Type: GrantFiled: July 11, 1995Date of Patent: August 26, 1997Assignee: L'OrealInventors: Josiane Allec, Eve Ferrara, Isabelle Bara
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Patent number: 5658956Abstract: The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.Type: GrantFiled: May 22, 1995Date of Patent: August 19, 1997Assignee: Warner-Lambert CompanyInventors: Alain Martin, Sau-Hung S. Leung
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Patent number: 5656628Abstract: This invention relates to the use of L-acylcarnitine for the preparation of a drug and a technique for relieving the disease symptoms appearing in AIDS by administering an L-acylcarnitine. The invention furthermore relates to a drug for this purpose, characterized in content by L-acylcarnitine as active principle. The preferred L-acylcarnitine is L-acetylcarnitine.Type: GrantFiled: December 27, 1994Date of Patent: August 12, 1997Assignee: ZW Biomedical Research AGInventors: Roger Weil, Laura Scandurra
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Patent number: 5654171Abstract: The present invention relates to a polypeptide (CIF Cornifation Inhibiting factor) characterized in that the polypeptide has a sequence of 212 amino acid residues represented by the formula (1) and a molecular weight of about 24000 daltons as determined by SDS-PAGE, a process for preparing the polypeptide, pharmaceutical compositions and cosmetics comprising the polypeptide, and a method of preventing or curing symptoms of skin diseases due to abnormal cornification of the skin with use of the polypeptide.Type: GrantFiled: December 5, 1994Date of Patent: August 5, 1997Assignee: Earth Chemical Company, Ltd.Inventors: Hidekazu Suginaka, Motoyuki Sugai, Yonman Hon, Hideo Ogai
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Patent number: 5650145Abstract: Dermatological/cosmetic compositions for reducing or decelerating human hair loss comprise an effective hair loss-reducing amount of combinatory immixture of (a) at least one antifungal agent and (b) at least one halogenated antibacterial agent other than a macrolide or pyranoside, characteristically formulated in a topically physiologically acceptable medium therefor.Type: GrantFiled: May 5, 1995Date of Patent: July 22, 1997Assignee: L'OrealInventor: Didier Saint-Leger
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Patent number: 5648101Abstract: A method of delivering NO gas to a desired situs on or in the body of a sentient animal, e.g. humans, comprising combining and causing to react a soluble reducing salt, preferably ferrous sulfate, and a nitrite, preferably sodium nitrite, as reactants in the presence of moisture in situ at or adjacent such situs. Means for such delivery include compositions such as tablets, capsules, ointments, creams, lotions, and sprays containing mixtures of particles or granules of the two reactants, and transdermal patches and osmotic pumps for combining solutions of reactant or reactants in situ.Type: GrantFiled: November 14, 1994Date of Patent: July 15, 1997Inventor: Rashad Tawashi