Abstract: A method of treating damaged tissue by applying a composition to the damaged tissue in an amount effective to treat the damaged tissue. The composition includes a semi-occlusive ointment base and salicylic acid in an amount effective to produce keratoplasticity.

Abstract: The invention relates to a cosmetic for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known cosmetics is the inadequate oxygen supply to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by a cosmetic containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier suitable for dermatological use. Preparation is effected by emulsification of the corresponding constituents, and use in ointments, creams, lotions, waters, alcoholic extracts, pastes, powders, gels, tinctures or on dressings and plasters or in a spray.

Abstract: The invention relates to a preparation for topical use, having light protection properties and in a special application form. In the known light protection agents containing the naturally occurring active compound melanin, the problem is inadequate transport of the melanin to its site of action. According to the invention, this problem is solved by a preparation for topical use which is characterised in that it contains melanin, dissolved or dispersed in one or more fluorocarbons, which are present as asymmetric lamellar phospholipid aggregates in an aqueous system together with a phospholipid, with a particle size of the aggregates in the range from 200 to 3000 nm.

Abstract: The invention relates to a dermatological agent for assisting the transport of oxygen in the skin, a process for its preparation and the use thereof. The problem with the known dermatological agents is the inadequate supply of oxygen to the skin and the adjoining tissue. The object of the invention is therefore to get through the horny layer of the skin and the epidermis by penetration processes in order to increase the oxygen concentration in the dermal area and adjoining tissue and to activate metabolic processes. According to the invention, this is effected by means of a dermatological agent containing asymmetric lamellar aggregates, consisting of phospholipids and oxygen-laden fluorocarbon or fluorocarbon mixture, the amount of fluorocarbon being in the range from 0.2 to 100% weight/volume, in a carrier which is suitable for dermatological use.

Abstract: This invention is directed to a method for reducing pyrimidine photoproducts comprising applying an effective amount of melanin to human skin prior to exposure to ultraviolet rays, wherein said melanin is in a vehicle suitable for topical application and measuring the amount of pyrimidine photoproducts as compared to a control sample. Another embodiment of this invention is where the vehicle is an ointment, cream or lotion. For the purpose of this invention, measuring also means determining, and/or quantifying.

Abstract: A method is disclosed for using a topical genital lubricant with a non-toxic, non-irritating zinc salt during sexual intercourse. The lubricant is spread upon one or more genital surfaces to create an anti-viral chemical barrier that reduces the risk of infection by the human immunodeficiency virus (HIV), the virus that causes AIDS. Suitable zinc salts include zinc acetate, zinc propionate, and other non-irritating water-soluble organic zinc salts that dissociate readily. When dissolved in water, these salts release divalent zinc ions (Zn.sup.++), which apparently can reduce HIV infectivity by at least three mechanisms. First, zinc ions form crosslinking bonds with cysteine and histidine residues in proteins (such as the gp120 protein of HIV), thereby "gluing" HIV particles to each other, to proteins in vaginal fluids, and to dead or dying cells that will soon be sloughed off from the genital surfaces. This reduces the ability of the HIV to infect susceptible cells.

Abstract: A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.

Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.

Abstract: The invention relates to the use of estriol as the sole active ingredient for the production of a transdermal medicament which continuously releases the active ingredient for the treatment of climacteric osteoporosis. It has been shown according to the invention that estriol, which has up until now been thought ineffective for the treatment of climacteric osteoporosis, develops strong anti-osteoporotic effectiveness upon continuous transdermal application.

Abstract: Transdermal preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance form the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such transdernal preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.

Abstract: This invention relates to an article of manufacture comprising an aqueous gel containing a selected zinc salt contained within a deformable plastic-walled tubular container, for convenient and consistent use as a topical genital lubricant during acts of sexual intercourse. The zinc salt must be organic, water-soluble, and have substantial dissociation rates to release divalent zinc ions. Suitable zinc salts include zinc acetate, zinc propionate, zinc butyrate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, and zinc lactate. The gel must also contain a thickening agent (such as chemically treated cellulose) and a lubricating agent (such as glycerin), and it must be free of heparin, dextran sulfate, or any other anti-coagulant or other component which poses a substantial risk of adverse effects if the lubricant is used frequently and repeatedly over a period of months or years.

Abstract: A method of making poultice by mixing together water, fine mineral powder, vinegar, herbal liniment solution, and hydrated magnesium sulfate (also known as Epsom salt) to produce a poultice capable of being applied to muscles, joints, or both which may be sore, injured, or both.

Abstract: An ointment comprising an adenosine 3',5'-cyclic phosphate derivative, a base having water-absorbing and drying properties and, incorporated in the base, is one or more salts each having pH in an aqueous solution of from 3 to 7. The ointment maintains the active ingredient in a stable state over an extended period of time.

Abstract: The present invention is directed to a method and apparatus for the topical application of opioid analgesic drugs such as morphine. Specifically, the present invention relates to a topical application of the opioid drug and specifically a morphine sulphate in a diluted solution to produce an analgesic effect in a localized area and typically in a localized inflamed area and without a transdermal migration of the opioid drug into the blood stream.

Abstract: Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for using the topical compositions in treatment of herpes disease.

Abstract: A pharmaceutical composition for transdermal delivery comprising an effective amount of an active ingredient selected from a benzodiazepine and a benzodiazepine antagonist; isopropanol; propylene glycol; oleic acid; and water. Additionally, the composition may contain diacetin, Cetiol B.RTM., caprylic acid, Silicon fluid, Miglyol.RTM. 840 or transcutol.

Abstract: A topical bioadhesive ointment composition comprising an aqueous mineral oil emulsion which is readily spread able and film-forming, and, upon application to moist skin or a mucosal surface, forms a stable, coherent layer thereon which resists removal therefrom by water or a body fluid associated with the mucosal surface to which the ointment composition is applied is disclosed. Also disclosed are pharmaceutical compositions containing the ointment compositions and a pharmaceutically active agent, e.g. , TGF.alpha.; and methods of using and methods of preparing the compositions.

Abstract: Compositions containing silver ammonium phenytoin complex and a phenytoin are usefully employed, particularly when applied topically, for the treatment of animal or human tissue, for wound healing and are useful in wound dressing preparations for the prevention or treatment of infections. The compositions are usefully applied by direct topical application to the wound or tissue to be treated or may be directly applied to the wound or tissue or incorporated in or coated on a dressing, such as a bandage.

Abstract: A pharmaceutical composition for transdermal delivery comprising an effective amount of an active ingredient selected from a benzodiazepine and a benzodiazepine antagonist; ethanol; caprylic acid; and oleic acid. Additionally, the composition may contain silicon fluid, benzyl alcohol, transcutol or dimethyl sulfoxide.

Abstract: A method is disclosed for reducing the risk of infection by sexually transmitted viruses. This method involves spreading a lubricant fluid containing a selected zinc salt across the surfaces of the penis or vagina, before intercourse, in a manner that causes the lubricant to coat and remain in contact with the genital surfaces throughout intercourse. The zinc salt should be organic, water-soluble, non-irritating, physiologically acceptable, and have a high rate of dissociation, which allows it to release substantial quantities of divalent zinc ions. Suitable zinc salts include zinc acetate, zinc propionate, zinc butyrate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, and zinc lactate. A preferred carrier fluid comprises a lubricant gel, which also contains water, a thickening agent (such as chemically treated cellulose) and a lubricating agent (such as glycerin).

Abstract: A method and compositions for reducing the itch associated with the bite of a blood-feeding insect such as a mosquito or black fly are disclosed. The method entails applying a topical pharmaceutical formulation of papain, pancreatin or subtilisin, optionally including urea, to the skin proximate to the bite. Compositions are provided in the form of solutions, lotions, ointments and salves containing papain, pancreatin or subtilisin and, optionally, urea.

Abstract: A low-sensitizing medicament for use in treating skin-tear injuries includes an emulsified water and hydrocarbon carrier portion, an emollient portion, a hydroxyquinoline antimicrobial portion, a mild keratolytic portion, and a paraben preservative portion. Additional ingredients include a zinc oxide topical protectant, vitamin E, a buffer or alkalizer agent that adjusts pH in a range from 6.5 to 6.8, and a scenting agent.

Abstract: The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic derivative thereof having the structure: ##STR2## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH.sub.2 --.

Abstract: A long-lasting antifungal vaginal cream composition having stable viscosity at human body temperature is disclosed.

Abstract: A method for treating a papilloma virus infection comprising topically administering hypericin which is effective to inhibit the replication, growth and/or the infectivity of the virus. The papilloma viruses include those capable of causing benign warts or a malignancy such as human papilloma virus-1 (HPV-1), HPV-2, HPV-6, HPV-11, HPV-16 and HPV-18.

Abstract: A pharmaceutical ointment is disclosed containing to 10 percent by mass of micronized piroxicam, 15 to 30 percent by mass of hydrophobic carrier(s), 60 to 75 percent by mass of water, 0.1 to 10 percent by mass of additive(s), and 2 to 5 percent by mass of emulsifiers selected from (i) a poly(ethylene glycol) alkyl or alkenyl ether and (ii) a sorbitane ester of a fatty acid or an oleic acid in a mass ratio of 3:1 to 1:3. The ointment is free from skin irritative action and has local antiphlogistic activity. In addition, a process for preparing he pharmaceutical ointment is provided.

Abstract: Disclosed is a semi-solid pharmaceutical agent containing a stabilized proteinaceous bioactive substance prepared by successively mixing an oligosaccharide and an aqueous solution of a proteinaceous bioactive substance, and kneading the resultant solids with an oil or fat base. The pharmaceutical handles with ease because it is readily administered to the body through percutaneous and permucosal route which are safer and less in pain administration routes than other conventional administrations.

Abstract: Novel compositions comprising an antiandrogenic compound of the formula ##STR1## wherein R is COR.sub.1 wherein R.sub.1 is loweralkyl and a vehicle comprising a metabolism modulator and a polar organic solvent, and a method of controlling the membrane permeation and metabolism of the compound thereof are disclosed.

Abstract: A composition and method of moisturizing mammalian vaginal membranous tissue is disclosed. The composition utilized in this method includes water, a bioadhesive polymer as the moisturizing agent and a consistency-enhancing agent. The bioadhesive is a water-swellable, but water-insoluble, particulate, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether. The consistency-enhancing agent is a watersoluble or -dispersible anionic or non-ionic polymer. The composition is contacted with the vaginal mucous membrane to be moisturized, and that contact is maintained for a time period sufficient to moisturize the contacted area.

Abstract: Herein is disclosed a cosmetic or an external preparation containing, as an oleo-phase component, an oil-soluble N-long chained acyl acidic amino acid mono- or di-ester having at least one sterol ester in the molecule, which is a novel compound of excellent emulsifying and hydrating performances.

Abstract: The present invention is a method for restricting the flow of airborne contaminants into a nasal passage. It involves creating an electrostatic field in an area near a human nasal passage. The electrostatic field may either repel or attract airborne contaminants or both. The method involves applying a topical application having a plurality of masses of one or more electrostatic materials, and a carrier having the plurality of masses dispersed therein. The masses have an average cross sectional area of about one square millimeter to about 50,000 square millimeters, and are of sufficient charge to create an electrostatic field which will prevent at least some airborne contaminants from passing into a human nasal passage. The topical application may be in the form of a solution, a semisolid, a solid, a spray solution or a vaporizable solution.

Abstract: New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.

Abstract: Composition for slowing down hair loss and inducing and stimulating its growth, comprising a compound of the following formula: ##STR1## wherein R.sub.1 and R.sub.3 denote H; R.sub.2 and R.sub.4 denote H or an alkyl; R.sub.5 denotes H, an alkyl, an alkenyl, a cycloalkyl, an aryl, an arylalkyl, a hydroxyalkyl or an aminoalkyl; X denotes H, halogen, alkyl, nitro, benzoyloxy or --NHR.sub.6 where R.sub.6 denotes H, acyl or alkyl; Z denotes sulfur or oxygen, with the proviso that Z denotes sulfur when X denotes H or R.sub.5 denotes aryl; Y denotes oxygen or OSO.sub.3 ; as well as its physiologically acceptable salts.

Abstract: This invention relates to a transdermal preparation comprising a therapeutically active compound of the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, which can be the same or different are H, CH.sub.3, C.sub.2 H.sub.5 or Cl; X is CH.dbd.CH or (CH.sub.2).sub.n where n is 1 to 3 or X is --C(OR.sub.5)H-- where R.sub.5 is methyl or ethyl; and R.sub.4 is hydrogen or a straight alkyl of 1 to 4 carbon atoms. The transdermal administration of the compounds can be accomplished by preparations in the form of ointments, emulsions, lotions, solutions, creams or transdermal patches.

Abstract: A medicinal composition for topical application and for use in a method of treatment for genital herpes and other inflammations of the genitalia includes as active ingredients tea tree oil, pau d'arco powder (an extract of lapacho), licorice root extract, and echinacea extract with a local anesthetic, preferably pramoxine hydrochloride. The composition may include soothing ingredients such as aloe vera extract and chamomile extract and is preferably formulated in a cream base.

Abstract: Novel topical anesthetic compositions containing high concentrations of benzocaine in a micronized powder form suspended in an emollient vehicle.

Abstract: A novel skin lotion consisting of a mixture of lye, oils, alcohol, coal tar, and menthol U.S.P. The mixture provides a cleansing lotion that readily treats psoriasis. When the mixture is applied to the skin, the lye provides a soap for cleansing and the base oil operates to soften and moisturize the skin. The use of a coal tar solution including alcohol penetrates the dermis of the skin to reduce inflammation. The addition of menthol U.S.P. helps cool the affected area and lessens itching.

Abstract: A topical agent and method for the treatment and prevention of pseudofolliculitis barbae, related secondary bacterial infections and other skin conditions associated with shaving result from a combination of three ingredients, namely benzoyl peroxide, camphor oil and aloe vera present in 15:4:1 parts by volume of the composition, respectively.

Abstract: A process for the production of semisolid preparations containing micronized active ingredients is described which is characterized in that a mixture of one or two nonionic surfactants with an HLB of 9 to 18 with 2.3 to 100 times the amount by weight of a fatty acid ester of general formulaR.sub.1 --COO--R.sub.2in which R.sub.1 and R.sub.2 each represent alkyl groups or alkenyl groups with 12 to 32 carbon atoms, or a mixture of these fatty acid esters is heated until it melts, the melt with stirring is put into 10 to 200 times the amount by weight of a semisolid preparation, which is heated approximately to the same temperature, the mixture is allowed to cool with stirring and mixed with the micronized active ingredient or active ingredient mixture as well as optionally with scents.

Abstract: An adhesive patch for percutaneous delivery of isosorbide dinitrate includes a piece of separating paper; a percutaneous salve preparation which is solvent free and which is comprised of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; and (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a surface coating material which is polymer

Abstract: A sunscreen composition comprising a water-in-oil emulsion which comprises an aqueous phase and an oil phase, the oil phase comprising an organic sunscreen agent and polyethylene, the oil phase having suspended therein microfine zinc oxide having a particle size in the range of from about 0.01 to about 0.25 microns, the amount of sunscreen agent being in the range of from about 1% to about 12%, the amount of polyethylene being in the range of from about 0.2% to about 5% and the amount of zinc oxide being in the range of from about 1% to about 10%, the percentages being by weight based on the weight of the water-in-oil emulsion.

Abstract: An anti-peroxide external preparation for skin comprising: decomposition product of shell membrane: and tocopherol and/or derivatives thereof. It is possible to suppress formation of peroxide and remove it.

Abstract: Methods and compositions are offered for reducing nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia), where intradermal delivery of lidocaine is maintained for a predetermined period of time. The lidocaine appears to specifically affect the damaged nerve fibers, while leaving the undamaged and normal nerve fibers with retention of response to other stimuli. Lidocaine formulations are provided which allow for the necessary dosage of the lidocaine in the dermis during the period of treatment. The formulation may be covered with an occlusive or non-occlusive dressing, which protects the lidocaine formulation from mechanical removal and enhances the transport of the lidocaine into the dermis. Long term relief is realized after maintenance of the administration of lidocaine has been terminated.

Abstract: A pranoprofen-containing, suspending medicinal composition is formed of the following three ingredients (a) to (c):(a) pranoprofen;(b) a suspending agent comprising microcrystalline cellulose-sodium carboxymethylcellulose, sodium carboxymethylcellulose and hydroxypropyl methylcellulose; and(c) a saccharide solution.

Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.

Abstract: An ointment comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny l]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1 .0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, or the like, a solubilizing and/or absorption-promoting agent and an ointment base, which is useful for treating various skin diseases.

Abstract: There is described herein a wound healing enhancing medicinal composition formulated from the salivary protein Lumicarmine. Lumicarmine is a phosphoglycoprotein with a molecular weight of 34.5 kD. About 80% of the total amino acid residues are proline glycine and glutamic acid and another 10% are lysine and arginine. Lumicarmine stains pink violet after gel electrophoresis and staining with Coomassie Brilliant Blue R-250 dye.

Abstract: A therapeutic agent for allergic diseases containing as an active ingredient an extract of Acanthopanax senticosus Harms. It became possible to provide a medicine enabling allergic diseases to be treated without causing almost no side effects.

Abstract: A method of treating conditions of amine vaginitis, purulent vaginitis and dysplasia of the mouth of the uterus resulting from papilloma virus infection in the genital region of female animals by topically applying ascorbic acid to the affected region. The invention also provides a medicinal composition in the form of a an ointment or tablet containing about 3% to about 50% by weight of ascorbic acid and the balance a pharmaceutically acceptable ointment or tabletting carrier.

Abstract: Skin barrier paste compositions free from organic solvents comprised of at least a rubber component and a filler component wherein the rubber component includes a liquid rubber having an average molecular weight of about 1,000 to about 80,000 and a viscosity of about 200 poise to about 6,000 poise at 40.degree. C., the rubber component being present in the paste composition in the range of about thirty percent to about seventy percent by weight. The present inventive paste compositions can be freely formed with the fingertips or a spatula; they are less irritating to the skin, mucosa and/or the injured area; and they are less susceptible to a viscosity change when exposed to the atmosphere, thus assuring an ease of application and a stable paste formulation when stored in a container.