Silicon-containing Organic Polymer Patents (Class 523/107)
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Publication number: 20140155515Abstract: A silicone hydrogel composition is disclosed. The composition includes at least one silicone macromer, a hydroxy-functionalized silicone-containing monomer, a first hydrophibic monomer and at least one crosslinker, in which the first hydrophibic monomer is N-vinyl pyrrolidone. The silicone macromer and the hydroxy-functionalized silicone-containing monomer are mutually soluble with N-vinylpyrrolidone. Silicone hydrogel contact lenses prepared from the silicone hydrogel composition are also disclosed.Type: ApplicationFiled: April 25, 2013Publication date: June 5, 2014Applicant: Pegavision CorporationInventors: Yu-Chin LAI, Min-Tzung YEH, Heng-Yi LI, Wei-Jia TING
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Patent number: 8741981Abstract: The invention provides silicone hydrogel contact lenses that exhibit reduced back surface debris and reduced incidence of superior epithelial arcurate lesions.Type: GrantFiled: February 7, 2013Date of Patent: June 3, 2014Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Robert B. Steffen, David C. Turner, Douglas G. Vanderlaan
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Patent number: 8729149Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount of 7.5% or greater by weight, a hydrophilic substituted N-vinyl acetamide monomer, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.1 to 1.Type: GrantFiled: April 22, 2013Date of Patent: May 20, 2014Inventors: Timothy Higgs, Tristan Tapper, Richard Young
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Publication number: 20140131227Abstract: Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.Type: ApplicationFiled: January 20, 2014Publication date: May 15, 2014Applicant: CooperVision International Holding Company, LPInventors: Guigui Wang, Yun Zhang, Yuwen Liu, Ye Hong, Charlie Chen, Peter Zhu
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Patent number: 8703875Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.Type: GrantFiled: February 27, 2013Date of Patent: April 22, 2014Assignee: Novartis AGInventors: Frank Chang, Norberto Arturo Medina
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Patent number: 8697770Abstract: A method for making a hydrogel, photochromic contact lens including supplying a first lens composition comprising a contact lens monomer and a photochromic material to a front contact lens mold and supplying a second lens composition to said contact lens mold wherein the viscosity of said first composition is at least about 1000 cp greater than the viscosity of said second contact lens composition, and the makeup of said second composition matches the of said first composition to reduce strain between said compositions of the resulting lens.Type: GrantFiled: April 8, 2011Date of Patent: April 15, 2014Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Donnie J. Duis, Yongcheng Li, Leilani K. Sonoda, Holly L. Grammer
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Publication number: 20140100291Abstract: The invention provide a class of actinically-crosslinkable silicone-containing prepolymers obtained by functionalizing an intermediary copolymer to have two or more thiol or ethylenically-unsaturated groups covalently attached thereto, wherein the intermediary copolymer is an atom-transfer radical polymerization (ATRP) product of a reactive mixture comprising a polysiloxane ATRP macroinitiator and at least one hydrophilic vinylic monomer. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.Type: ApplicationFiled: December 11, 2013Publication date: April 10, 2014Applicant: Novartis AGInventors: Frank Chang, Jinyu Huang, Robert Scott, Guigui Wang
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Patent number: 8680172Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.Type: GrantFiled: April 23, 2013Date of Patent: March 25, 2014Assignee: Visiogen, Inc.Inventor: Xiugao Liao
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Publication number: 20140066540Abstract: Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.Type: ApplicationFiled: August 27, 2013Publication date: March 6, 2014Applicant: CooperVision International Holding Company, LPInventors: Hiroyuki Ueyama, Charlie Chen, Yuan Xu, Yuwen Liu, Ying Zheng, Paul Richardson, Prasad Dande
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Patent number: 8658747Abstract: Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts.Type: GrantFiled: May 31, 2013Date of Patent: February 25, 2014Assignee: CooperVision International Holding Company, LPInventors: Yuwen Liu, Charlie Chen, Charles A. Francis, Junhao Ge, Yuan Xu, Li Yao, Arthur Back, Ying Zheng
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Patent number: 8658748Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. The average energy loss of the silicone hydrogel contact lenses is from about 30% to about 45% when the lenses are fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: GrantFiled: May 31, 2013Date of Patent: February 25, 2014Assignee: CooperVision International Holding Company, LPInventors: Ronghua Liu, Xinfeng Shi, Yuwen Liu, Charlie Chen, Ye Hong, Charles A. Francis, Li Yao, Arthur Back, Ying Zheng
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Publication number: 20140049746Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.Type: ApplicationFiled: February 23, 2012Publication date: February 20, 2014Inventors: Yuwen Liu, Junhao Ge, Charlie Chen, Yuan Xu, Li Yao, Arthur Back, Charles A. Francis
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Publication number: 20140039086Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least one colorant, a solvent and a binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the colored coat has good adhesion to the silicone hydrogel contact lens without being covalently attached to the lens material of the contact lens. The invention also provides methods for making colored silicone hydrogel contact lenses.Type: ApplicationFiled: October 4, 2013Publication date: February 6, 2014Applicant: Novartis AGInventor: John Christopher Phelan
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Patent number: 8642677Abstract: Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.Type: GrantFiled: February 24, 2012Date of Patent: February 4, 2014Assignee: CooperVision International Holding Company, LPInventors: Guigui Wang, Yun Zhang, Yuwen Liu, Ye Hong, Charlie Chen, Peter Zhu
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Publication number: 20140031449Abstract: The present invention relates to silicone hydrogels having a desirable balance of properties which can be formed without diluents. The silicone hydrogels are formed from reactive mixtures comprising at least one hydroxyl substituted, monofunctional polydialkylsiloxane monomer having between 2 and 120 dialkylsiloxane repeating units, at least one slow reacting hydrophilic monomer and at least one hydroxyl containing hydrophilic monomer.Type: ApplicationFiled: December 19, 2012Publication date: January 30, 2014Applicant: Johnson & Johnson Vision Care, Inc.Inventor: Johnson & Johnson Vision Care, Inc.
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Patent number: 8637621Abstract: A hydrogel soft contact lens which is superior in extended-wearability, lens movement, wear comfort, and which does not adhere to a cornea when worn is provided. The lens provided can be a silicone hydrogel contact lens which contains units of hydrophilic siloxane monomers and amide-group-containing monomers having an N-vinyl group.Type: GrantFiled: December 3, 2010Date of Patent: January 28, 2014Assignee: CooperVision International Holding Company, LPInventors: Junichi Iwata, Tsuneo Hoki, Seiichirou Ikawa
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Patent number: 8637588Abstract: An optical synthetic resin composed of: a synthetic resin; and fine particles dispersed in the synthetic resin at a ratio of 0.1 vol % or more to 50 vol % or less, each having a maximum length of 1 nm or more to 30 nm or less, in which part of surfaces of the fine particles are modified with functional groups which themselves repel each other, and a distance between two arbitrary adjacent fine particles among the fine particles is in a range of 0.1 nm or more to 500 nm or less. The two arbitrary adjacent fine particles attract each other with an intermolecular force, thereby making it possible to provide an optical composite deviating from an additivity range.Type: GrantFiled: October 3, 2006Date of Patent: January 28, 2014Assignee: Canon Kabushiki KaishaInventors: Yasuhiro Tanaka, Katsumoto Hosokawa, Kazutaka Takeuchi
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Patent number: 8637589Abstract: In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: December 7, 2010Date of Patent: January 28, 2014Assignees: Johnson & Johnson Vision Care, Inc., Toray IndustriesInventors: Kazuhiko Fujisawa, Mitsuru Yokota, Masataka Nakamura
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Publication number: 20140024738Abstract: Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: ApplicationFiled: February 23, 2012Publication date: January 23, 2014Applicant: CooperVision International Holding Company, LPInventors: Charlie Chen, Yuwen Liu, Yuan Xu, Ying Zheng, Junhao Ge, Li Yao, Arthur Back
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Publication number: 20140018465Abstract: Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: ApplicationFiled: February 23, 2012Publication date: January 16, 2014Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LPInventors: Yuwen Liu, Charlie Chen, Ye Hong, Charles A. Francis, Li Yao, Arthur Back
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Patent number: 8622543Abstract: The present invention provides an actinically or thermally curable ink for making colored silicone hydrogel contact lenses. The ink of the invention comprises at least one colorant, a solvent and a binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer. The ink of the invention is characterized by having capability to be cured actinically or thermally to form a colored coat on a silicone hydrogel contact lens, wherein the colored coat has good adhesion to the silicone hydrogel contact lens without being covalently attached to the lens material of the contact lens. The invention also provides methods for making colored silicone hydrogel contact lenses.Type: GrantFiled: May 13, 2009Date of Patent: January 7, 2014Assignee: Novartis AGInventor: John Christopher Phelan
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Patent number: 8623934Abstract: The present invention relates to a silicone (meth)acrylamide monomer, and this silicone (meth)acrylamide monomer is particularly suitable for use in contact lenses, intraocular lenses, artificial cornea, and the like.Type: GrantFiled: February 27, 2013Date of Patent: January 7, 2014Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Thomas L. Maggio, Michelle Carman Turnage, Michael R. Clark, Kazuhiko Fujisawa, Masataka Nakamura
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Patent number: 8614261Abstract: Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and/or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.Type: GrantFiled: March 26, 2012Date of Patent: December 24, 2013Assignee: CooperVision International Holding Company LPInventors: Junichi Iwata, Tsuneo Hoki, Seiichirou Ikawa, Arthur Back
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Patent number: 8609745Abstract: The invention provide a new lens curing method for making hydrogel contact lenses. The new lens curing method is based on actinically-induced step-growth polymerization. The invention also provides hydrogel contact lenses prepared from the method of the invention and fluid compositions for making hydrogel contact lenses based on the new lens curing method. In addition, the invention provide prepolymers capable of undergoing actinically-induced step-growth polymerization to form hydrogel contact lenses.Type: GrantFiled: December 12, 2012Date of Patent: December 17, 2013Assignee: Novartis AGInventors: Arturo Norberto Medina, Dawn Alison Smith, Robert Scott
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Publication number: 20130313733Abstract: A method of making a substantially fully copolymerized UV blocking hydrogel lens demonstrating sufficient blocking of UV light to meet at least FDA Class II specifications for UV blocking formed from a reaction mixture comprising at least NVP and one other comonomer and a free-radical polymerizable, substituted or unsubstituted, Bis O-hydroxy benzophenone is provided herein.Type: ApplicationFiled: May 25, 2012Publication date: November 28, 2013Inventors: Ivan Nunez, Jennifer Hunt
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Publication number: 20130317133Abstract: Provided are articles such as medical devices which comprise at least one water soluble, crosslinked copolymer. The primary polymer chains of the copolymer are hydrophilic and independently have a degree of polymerization in the range of about 10 to about 10,000. The water soluble, crosslinked copolymers of the present invention are free from terminal substrate associating segments. The copolymers may be incorporated into a formulation from which the article is made or may be contacted with the article post-formation.Type: ApplicationFiled: May 22, 2013Publication date: November 28, 2013Inventors: Charles W. Scales, Kevin P. McCabe, Brent Matthew Healy
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Publication number: 20130317131Abstract: Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g/mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment is located on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel.Type: ApplicationFiled: March 15, 2013Publication date: November 28, 2013Applicant: JOHNSON & JOHNSON VISION CARE, INC.Inventors: Charles W. Scales, Kevin P. McCabe, Brent Matthew Healy
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Publication number: 20130317132Abstract: The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one polymer comprising repeating units from N-(2-hydroxyalkyl)(meth)acrylamide.Type: ApplicationFiled: May 22, 2013Publication date: November 28, 2013Inventors: Charles W. Scales, Kevin P. McCabe, Brent Matthew Healy
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Patent number: 8585938Abstract: UV absorbing compounds that are effective in blocking UV and short-wavelength blue light are disclosed. The UV absorbing compounds are particularly suitable for use in intraocular lens materials.Type: GrantFiled: March 29, 2013Date of Patent: November 19, 2013Assignee: Novartis AGInventors: David L. Jinkerson, Walter R. Laredo
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Publication number: 20130274371Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount of 7.5% or greater by weight, a hydrophilic substituted N-vinyl acetamide monomer, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.Type: ApplicationFiled: April 22, 2013Publication date: October 17, 2013Applicant: Contamac, Ltd.Inventor: Contamac, Ltd.
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Patent number: 8557892Abstract: Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing macromer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.Type: GrantFiled: June 1, 2012Date of Patent: October 15, 2013Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8552085Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.Type: GrantFiled: July 2, 2012Date of Patent: October 8, 2013Assignee: CooperVision International Holding Company, LPInventors: Ye Hong, Charlie Chen, Nick Manesis
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Publication number: 20130260066Abstract: The present invention provides transparent silicone hydrogels with high acrylamide monomer content and an excellent balance between moisture content. The silicone hydrogels may be obtained by polymerizing a monomer mix containing a plurality of monomers, wherein the monomer mix comprises about 30 to about 98% by weight of at least one type of silicone monomer which is, and about 1 to about 50% by weight of at least one type of non-silicone type (meth)acrylamide monomer containing two or more hydroxyl groups within a molecule; wherein the weight percents are based upon the total amount of monomer components and polymer components in the monomer mix.Type: ApplicationFiled: May 31, 2013Publication date: October 3, 2013Inventors: Thomas L. Maggio, Michelle Carman-Turnage, Kazuhiko Fujisawa, Masataka Nakamura
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Publication number: 20130261215Abstract: The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.Type: ApplicationFiled: May 21, 2013Publication date: October 3, 2013Applicant: Johnson & Johnson Vision Care, Inc.Inventors: Osman Rathore, Zohra Fadli, Mark Lada, James D. Ford, Azaam Alli, Yongcheng Li
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Publication number: 20130255192Abstract: Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts.Type: ApplicationFiled: May 31, 2013Publication date: October 3, 2013Inventors: Yuwen Liu, Charlie Chen, Charles A. Francis, Junhao Ge, Yuan Xu, Li Yao, Arthur Back, Ying Zheng
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Publication number: 20130261216Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. The average energy loss of the silicone hydrogel contact lenses is from about 30% to about 45% when the lenses are fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: ApplicationFiled: May 31, 2013Publication date: October 3, 2013Applicant: CooperVision International Holding Company, LPInventors: Ronghua Liu, Xinfeng Shi, Yuwen Liu, Charlie Chen, Ye Hong, Charles A. Francis, Li Yao, Arthur Back, Ying Zheng
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Patent number: 8541483Abstract: The present invention relates to a silicone (meth)acrylamide monomer, and this silicone (meth)acrylamide monomer is particularly suitable for use in contact lenses, intraocular lenses, artificial cornea, and the like.Type: GrantFiled: February 27, 2013Date of Patent: September 24, 2013Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Thomas L. Maggio, Michell Carman Turnage, Michael R. Clark, Kazuhiko Fujisawa, Masataka Nakamura
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Publication number: 20130237631Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.Type: ApplicationFiled: March 22, 2013Publication date: September 12, 2013Applicant: Johnson & Johnson Vision Care, Inc.Inventors: Kevin P. McCabe, Frank F. Molock, Jr., Gregory A. Hill, Azaam Alli, Robert B. Steffen, Douglas G. Vanderlaan, James D. Ford
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Publication number: 20130225715Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.Type: ApplicationFiled: March 22, 2013Publication date: August 29, 2013Applicant: Johnson & Johnson Vision Care, Inc.Inventor: Johnson & Johnson Vision Care, Inc.
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Patent number: 8513325Abstract: Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.Type: GrantFiled: February 24, 2012Date of Patent: August 20, 2013Assignee: CooperVision International Holding Company, LPInventors: Yuwen Liu, Charlie Chen, Ye Hong, Charles A. Francis, Li Yao, Arthur Back
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Patent number: 8513324Abstract: The present invention relates to a composition comprising a hydrogel polymer having less than 100% haze, and distributed therein an oxygen enhancing effective amount of oxygen permeable particles having an oxygen permeability of at least about 100 barrer, average particle size less than about 5000 nm.Type: GrantFiled: January 9, 2013Date of Patent: August 20, 2013Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Charles W. Scales, Gregory A. Hill, John B. Enns, Eric R. George
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Patent number: 8507577Abstract: The present invention is a process for forming ophthalmic devices such as contact lenses, comprising the steps of curing a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component and at least one protonated diluent or protonatable diluent having a Hansen solubility parameter, ?p between about 2 and about 7 to form an ophthalmic device having an advancing contact angle of less than about 80°; contacting the ophthalmic device with an aqueous solution which is capable of changing the Hansen solubility parameter, ?p of the protonated or protonatable co-diluent to enhance water solubility and removing said diluent(s) with said aqueous solution.Type: GrantFiled: October 18, 2007Date of Patent: August 13, 2013Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Diana Zanini, Karen Altheim
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Patent number: 8501833Abstract: The present invention provides a method and a formulation for consistently producing a silicone hydrogel material having relatively high oxygen permeability, relatively high ion permeability, and low modulus, and contact lenses prepared from a formulation of the invention or made of a silicone hydrogel material of the invention.Type: GrantFiled: May 18, 2010Date of Patent: August 6, 2013Assignee: Novartis AGInventor: John Christopher Phelan
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Patent number: 8501878Abstract: According to the present invention, a contact lens material being excellent in oxygen permeability and transparency, being capable of undergoing injection molding, having no water content and having flexibility, as well as a contact lens gel material having excellent oxygen permeability and transparency can be provided. The present invention relates to a contact lens material comprising a polycarbonate resin derived from at least two compounds among compounds represented by a general formula (A), a general formula (B) and a general formula (C), a highly polar molecular weight control modifier (chain terminator) and a compound forming a carbonic acid ester, wherein the compound of the general formula (A) is essentially comprised, and to a production method thereof.Type: GrantFiled: July 15, 2009Date of Patent: August 6, 2013Assignees: Menicon Co., Ltd., Mitsubishi Gas Chemical Company, Inc., Shin-Etsu Chemical Co., Ltd.Inventors: Yasuhiko Suzuki, Kazuhiko Nakada, Tsuyoshi Watanabe, Takahiro Adachi, Mamoru Hagiwara, Masahiko Minemura
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Publication number: 20130197125Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polymerizable group containing polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.Type: ApplicationFiled: March 1, 2013Publication date: August 1, 2013Applicant: Bausch & Lomb IncorporatedInventor: Bausch & Lomb Incorporated
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Publication number: 20130184372Abstract: The present invention relates to a silicone polymer comprising a sulfonic acid component formed from reactive components comprising (i) at least one silicone component and (ii) at least one sulfonic acid-containing component, wherein the sulfonic acid-containing component is comprised of a non-polymerizable, hydrophobic cation and a polymerizable sulfonic acid.Type: ApplicationFiled: January 4, 2013Publication date: July 18, 2013Applicant: JOHNSON & JOHNSON VISION CARE, INC.Inventor: Johnson & Johnson Vision Care, Inc.
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Patent number: 8487058Abstract: Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: GrantFiled: February 24, 2012Date of Patent: July 16, 2013Assignee: CooperVision International Holding Company, LPInventors: Yuwen Liu, Charlie Chen, Charles A. Francis, Junhao Ge, Yuan Xu, Li Yao, Arthur Back, Ying Zheng
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Publication number: 20130175722Abstract: The present invention relates to aqueous processes for the production of silicone hydrogel contact lenses.Type: ApplicationFiled: March 4, 2013Publication date: July 11, 2013Applicant: JOHNSON & JOHNSON VISION CARE, INC.Inventor: JOHNSON & JOHNSON VISION CARE, INC.
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Patent number: 8481608Abstract: The invention provides a silicone monomer having high purity and suitable for use in the manufacture of ophthalmic devices, and a contact lens produced from the silicone monomer as a polymerizable component. The silicone monomer is represented by the formula (1): wherein Y1 to Y9 each independently stands for an alkyl group having 1 to 4 carbon atoms, n is an integer of 0 to 3, a and b each independently denotes an integer of 0 or 1, and R stands for a hydrogen atom or a methyl group.Type: GrantFiled: January 19, 2010Date of Patent: July 9, 2013Assignee: NOF CorporationInventors: Yosuke Matsuoka, Nobuyuki Yoshioka, Nobuyuki Sakamoto, Toshiya Itei, Ryota Kobayashi, Mao Sorimachi
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Patent number: 8481662Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.Type: GrantFiled: February 24, 2012Date of Patent: July 9, 2013Assignee: CooperVision International Holding Company, LPInventors: Ronghua Liu, Xinfeng Shi, Yuwen Liu, Charlie Chen, Ye Hong, Charles A. Francis, Li Yao, Arthur Back, Ying Zheng