Silicon-containing Organic Polymer Patents (Class 523/107)
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Publication number: 20120202916Abstract: Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing block copolymer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.Type: ApplicationFiled: February 7, 2012Publication date: August 9, 2012Applicant: NOVARTIS AGInventors: Walter R. Laredo, Xuwei Jiang
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Publication number: 20120193822Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.Type: ApplicationFiled: March 27, 2012Publication date: August 2, 2012Inventors: Kevin P. McCabe, Frank F. Molock, Gregory A. Hill, Azaam Alli, Robert B. Steffen, Douglas G. Vanderlaan, James D. Ford
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Patent number: 8232326Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: February 8, 2012Date of Patent: July 31, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8231218Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.Type: GrantFiled: June 11, 2007Date of Patent: July 31, 2012Assignee: Coopervision International Holding Company, LPInventors: Ye Hong, Charlie Chen, Nick Manesis
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Publication number: 20120136087Abstract: Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.Type: ApplicationFiled: June 7, 2010Publication date: May 31, 2012Applicant: DSM IP Assets B.V.Inventors: James Parakka, Ananth V. Iyer, Anfeng Wang, Xuwei Jiang, Yuan Tian, Robert Ward
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Publication number: 20120115979Abstract: The present invention provides a reactive hydrophilic polymer comprising units of Formulae (I) and (II): wherein the ratio of the mole number of the unit of Formula (I) to the total mole number of the units of Formulae (I) and (II) is from 0.002 to 0.04, and the reactive hydrophilic polymer has a molecular weight from 10,000 to 2,000,000. The present invention also provides a silicone hydrogel comprising the reactive hydrophilic polymer and ocular articles made therefrom.Type: ApplicationFiled: July 7, 2011Publication date: May 10, 2012Inventors: KEN-YUAN CHANG, CHIH-TA LEE, CHIA-CHANG LIU, CHUN-YI LI
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Publication number: 20120115980Abstract: Disclosed in this specification is a method for forming a silicone hydrogel material that is useful for forming contact lens materials. The method includes using an effective amount of a borate additive to reduce the gel time of the silicone hydrogel reactive mixture and/or enhance the optical properties of the resulting cured material.Type: ApplicationFiled: October 27, 2011Publication date: May 10, 2012Inventors: Douglas G. Vanderlaan, James D. Ford
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Patent number: 8173720Abstract: A transparent gel is disclosed which has an interpenetrating polymer network of a copolymer containing a polysiloxane structure and a polycarbonate structure and a hydrophilic polymer obtained by polymerizing a hydrophilic monomer. The transparent gel is useful as a cultivation substrate, a container for storage and an ophthalmic material, comprising an easily synthesizable and purifiable silicon-containing resin, wherein a gel strength, transparency, oxygen permeability, birefringence and other characteristics are excellent.Type: GrantFiled: January 13, 2006Date of Patent: May 8, 2012Assignees: Mitsubishi Gas Chemical Company, Inc., Menicon Co., Ltd.Inventors: Kazuhiko Nakada, Takahito Nakase, Takahiro Adachi, Akira Yamamoto, Masahiko Minemura
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Patent number: 8168735Abstract: The present invention provides a hydrophilic silicone which has a predetermined number of silicon atoms and a high purity and is suitable for producing an ophthalmic device and a process for preparing the same. The silicone compound is represented by formula (1) with a purity of 95% by weight or higher, wherein m is one value out of the integers of from 3 to 10, n is one value out of the integers of from 1 to 10, R1 is one out of alkyl groups having 1 to 4 carbon atoms, and R2 is one out of a hydrogen atom and a methyl group.Type: GrantFiled: May 26, 2009Date of Patent: May 1, 2012Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Shoji Ichinohe
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Patent number: 8168720Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.Type: GrantFiled: December 3, 2009Date of Patent: May 1, 2012Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Kevin P. McCabe, Frank F. Molock, Gregory A. Hill, Azaam Alli, Robert B. Steffen, Douglas G. Vanderlaan, James D. Ford
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Publication number: 20120088861Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.Type: ApplicationFiled: October 5, 2011Publication date: April 12, 2012Inventors: Jinyu Huang, Frank Chang, Robert Scott, Arturo Norberto Medina, Manivakkam J. Shankernarayanan, Selma Kuyu, Dawn Alison Smith, Daqing Wu
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Publication number: 20120088844Abstract: The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.Type: ApplicationFiled: October 5, 2011Publication date: April 12, 2012Inventors: Selma Kuyu, Dawn Alison Smith, Jinyu Huang, Frank Chang, Robert Scott, Arturo Norberto Medina, Manivakkam J. Shankernarayanan
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Publication number: 20120088843Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polysiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR—S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.Type: ApplicationFiled: October 5, 2011Publication date: April 12, 2012Inventors: Frank Chang, Jinyu Huang, Laura Ann Sanders
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Patent number: 8153703Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.Type: GrantFiled: November 3, 2009Date of Patent: April 10, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8148445Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a multi-arm PEG macromer.Type: GrantFiled: January 14, 2010Date of Patent: April 3, 2012Assignee: Novartis AGInventor: Walter R. Laredo
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Patent number: 8138288Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.Type: GrantFiled: March 3, 2011Date of Patent: March 20, 2012Assignee: Bausch & Lomb IncorporatedInventors: Jason K. Stanbro, Ivan M. Nunez, Jay F. Kunzler, Derek A. Schorzman
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Patent number: 8129442Abstract: A hydrophilic polysiloxane macromonomer containing polyoxyethylene as a hydrophilic side chains pendant to a polysiloxane main chain for imparting transparency, oxygen permeability, and hydrophilic properties to a contact lens is disclosed. The properties of the material are controlled by regulating the length of the polysiloxane main chain, the length of the hydrophilic polyoxyethylene side chains, and the number of the side chains.Type: GrantFiled: February 6, 2009Date of Patent: March 6, 2012Assignee: CooperVision International Holding Company, LPInventors: Hiroyuki Ueyama, Seiichiro Ikawa, Junichi Iwata
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Patent number: 8124668Abstract: [Problem] To provide a safe ocular lens material having high oxygen permeability, excellent surface wettability, the excellent lubricity/easy lubricating property of surface, little in surface adhesive and superior flexibility and stress relaxation, in addition, suppressing elution of a monomer from the final product. [Means for Solving the Problem] An ocular lens comprising a compound (A) having an ethylenically unsaturated group and polydimethylsiloxane structure through a urethane bond and an 1-alkyl-3-methylene-2-pyrrolidone (B).Type: GrantFiled: January 8, 2004Date of Patent: February 28, 2012Assignee: Menicon Co., Ltd.Inventors: Masaki Baba, Tsuyoshi Watanabe
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Publication number: 20120046382Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.Type: ApplicationFiled: October 28, 2011Publication date: February 23, 2012Inventors: Jian S. Zhou, Dawn A. Smith
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Publication number: 20120041097Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.Type: ApplicationFiled: October 28, 2011Publication date: February 16, 2012Inventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
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Patent number: 8114921Abstract: A macromolecule includes a polymer directly tethered or bonded to a polyatomic functionality. The polyatomic functionality can be located at a terminus of the polymer and can be generated concurrent with or soon after formation of the polymer. The macro-molecule can be prepared from a functionalized polymer by hydrolyzing and condensing (e.g., by a sol-gel process) functionalities in which one or more alkoxy groups are bound to a silica atom in the presence of an excess of a compound that includes a Si, Ti, Zr, Sn, Al, or Fe atom. Such macromolecules can be used in the manufacture of vulcanizates and tire components, either alone or blended with other polymers and/or other particulate fillers.Type: GrantFiled: December 17, 2007Date of Patent: February 14, 2012Assignee: Bridgestone CorporationInventors: Jason T. Poulton, Yuan-Yong Yan, Wang Hao
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Publication number: 20120029111Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.Type: ApplicationFiled: July 29, 2011Publication date: February 2, 2012Inventors: Frank Chang, Robert Scott, Jinyu Huang, Arturo N. Medina, Dawn A. Smith, Laura Ann Sanders, John Dallas Pruitt
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Publication number: 20120023869Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.Type: ApplicationFiled: July 20, 2011Publication date: February 2, 2012Inventors: Newton T. Samuel, John Dallas Pruitt, Daqing Wu, Selma Kuyu
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Publication number: 20120022180Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer which has only one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming comonomers are disclosed.Type: ApplicationFiled: September 7, 2011Publication date: January 26, 2012Inventors: Jeffrey G. Linhardt, Ivan M. Nunez, Joseph A. McGee, Jennifer Hunt, Michele Alton, Drazen Pavlovic, Devon A. Shipp
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Publication number: 20120010321Abstract: The invention provide a new class of silicone-containing prepolymers containing poly(oxyalkylene) blocks, polysiloxane blocks, and actinically-crosslinkable groups which are acryl groups, thiol groups, ene-containing groups or combinations thereof. A preopolymer of the invention is prepared in a one-pot procedure according to the Michael addition of thiol to electron deficient alkenes, such as ?,?-unsaturated carbonyl compounds, without need for additional reaction step(s) to introduce actinically crosslinkable groups. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.Type: ApplicationFiled: September 22, 2011Publication date: January 12, 2012Inventors: Frank Chang, Guigui Wang
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Patent number: 8088965Abstract: Methods accelerate healing of a wound by applying a multilayer bandage to the wound. The multilayer bandage has a spun-bonded webbing comprising at least one partially or completely hydrolytically condensed silicon compound and a water-impervious or semi-permeable first membrane having at least one water-insoluble polymer. The webbing has a biologically degradable or biologically resorbable structure and is brought into direct contact with the wound by placing the webbing in or on the wound.Type: GrantFiled: October 1, 2009Date of Patent: January 3, 2012Assignee: Bayer Innovation GmbHInventors: Axel Thierauf, Iwer Baecker, Andreas Haisch
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Publication number: 20110313077Abstract: Provided is a polymer material having superior water wettability and lubricity, and enabling persistence of the same by allowing the surfactant to be retained by the polymer material so as not to be gradually released. The present invention is directed to a polymer material including: [I] a polymer having a constitutional unit derived from (A) a polymerizable compound having an acryloyloxy group and not having a silicon atom; and [II] a surfactant. The content of the surfactant [II] is preferably 0.05% by mass or greater and 1% by mass or less. The surfactant [II] is preferably a nonionic surfactant having a polyoxyethylene group.Type: ApplicationFiled: March 31, 2011Publication date: December 22, 2011Inventors: Masaki Baba, Tsuyoshi Watanabe, Susumu Ogawa, Daisuke Sutou, Yuya Motoyama, Eri Miyasaka
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Patent number: 8071703Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.Type: GrantFiled: March 21, 2008Date of Patent: December 6, 2011Assignee: Novartis AGInventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
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Patent number: 8071696Abstract: The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.Type: GrantFiled: April 28, 2011Date of Patent: December 6, 2011Assignee: Novartis AGInventors: Thomas Hirt, Jacalyn Marie Schremmer, Troy Vernon Holland, Dieter Lohmann
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Patent number: 8071660Abstract: A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.Type: GrantFiled: December 8, 2008Date of Patent: December 6, 2011Assignee: Bausch & Lomb IncorporatedInventors: Weihong Lang, Yu-Chin Lai
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Patent number: 8071661Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.Type: GrantFiled: December 8, 2008Date of Patent: December 6, 2011Assignee: Bausch & Lomb IncorporatedInventors: Yu-Chin Lai, Weihong Lang
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Publication number: 20110294914Abstract: The present invention relates to biomedical devices, and particularly contact lenses comprising a polymer having entangled therein at least one acyclic polyamide.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Inventors: Osman Rathore, Shivkumar Mahadevan, Frank Molock, Azaam Alli, David Turner, Douglas G. Vanderlaan, Kevin P. McCabe
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Patent number: 8063265Abstract: A hydrogel having a floatability where from 40% to 90% of a solution and/or suspension to be thickened are thickened starting from the surface of the liquid and the rest of the solution and/or suspension to be thickened is thickened starting from the bottom of the container, a process for preparing the hydrogel and also its use for absorbing blood and/or body fluids, especially in hygiene articles, or for thickening aqueous solutions and/or suspensions, especially for thickening medical wastes.Type: GrantFiled: October 28, 2004Date of Patent: November 22, 2011Assignee: BASF AktiengesellschaftInventors: Martin Beck, Volker Frenz, Anna Kowalski, Elisabeth Selzer, Ernst Jürgen Bauer, Harald Keller, Bernhard Steinmetz
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Patent number: 8058323Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.Type: GrantFiled: January 23, 2009Date of Patent: November 15, 2011Assignee: Novartis AGInventors: Diana M. Cordova, Mutlu Karakelle, Chance Lehman, Douglas C. Schlueter, Joseph I. Weinschenk, III
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Publication number: 20110275734Abstract: The present invention relates to compositions comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer's backbone, a hydrophilic segment having a degree of polymerization of about 10 to about 1000, and a linear silicone segment at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel. The non-reactive hydrophilic polymers may be incorporated into the formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post formation.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Inventors: Charles SCALES, Kunisi Venkatasubban, Shivkumar Mahadevan, Zohra Fadli, Carrie Davis, Brent Matthew Healy
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Patent number: 8053489Abstract: Crosslink agents used to copolymerize at least one hydrophilic monomer with at least one lens monomer typically used to prepare polymeric materials for ophthalmic lenses. The crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer. Accordingly, the invention is also directed to a hydrophilic crosslinked polymer that comprises at least two monomeric units and at least two different crosslink units. The use of the dual crosslink system provides an improved means to control the final chemical, physical and structural characteristics of the resulting polymer.Type: GrantFiled: July 8, 2008Date of Patent: November 8, 2011Assignee: Bausch & Lomb IncorporatedInventors: Ivan M. Nunez, Joseph A. McGee, David E. Seelye
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Publication number: 20110269869Abstract: The invention provide a new lens curing method for making hydrogel contact lenses. The new lens curing method is based on actinically-induced step-growth polymerization. The invention also provides hydrogel contact lenses prepared from the method of the invention and fluid compositions for making hydrogel contact lenses based on the new lens curing method. In addition, the invention provide prepolymers capable of undergoing actinically-induced step-growth polymerization to form hydrogel contact lenses.Type: ApplicationFiled: July 14, 2011Publication date: November 3, 2011Inventors: Arturo Norberto Medina, Robert Scott, Dawn Alison Smith
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Patent number: 8044112Abstract: The invention provides a cost-effective method for making a silicone hydrogel contact lens having an LbL coating thereon that is not covalently attached to the lens and has good hydrophilicity, intactness and durability. The method comprises LbL coating at high temperature.Type: GrantFiled: March 21, 2007Date of Patent: October 25, 2011Assignee: Novartis AGInventor: Yasuo Matsuzawa
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Patent number: 8030423Abstract: Multi-armed macromonomers containing multiple side chains attached to a siloxy-containing core terminated on each end with one or more first substantially linear polysiloxane radicals having a polymerizable ethylenically unsaturated-containing terminal group, wherein each side chain comprises a second substantially linear polysiloxane radical having a polymerizable ethylenically unsaturated-containing terminal group are disclosed. Biomedical devices such as contact lenses formed from the multi-armed macromonomers are also disclosed.Type: GrantFiled: January 13, 2009Date of Patent: October 4, 2011Inventors: Joseph C. Salamone, Jay F. Kunzler
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Publication number: 20110230589Abstract: The present invention provides transparent silicone hydrogels with high acrylamide monomer content and an excellent balance between moisture content. The silicone hydrogels may be obtained by polymerizing a monomer mix containing a plurality of monomers, wherein the monomer mix comprises about 30 to about 98% by weight of at least one type of silicone monomer which is, and about 1 to about 50% by weight of at least one type of non-silicone type (meth)acrylamide monomer containing two or more hydroxyl groups within a molecule; wherein the weight percents are based upon the total amount of monomer components and polymer components in the monomer mix.Type: ApplicationFiled: March 15, 2011Publication date: September 22, 2011Inventors: Thomas L. Maggio, Michelle Carman Turnage, Kazuhiko Fujisawa, Masataka Nakamura
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Publication number: 20110208301Abstract: Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.Type: ApplicationFiled: February 23, 2011Publication date: August 25, 2011Inventors: David Anvar, Andrew Goodwin, David Chazan
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Patent number: 8003710Abstract: The invention provide a new lens curing method for making hydrogel contact lenses. The new lens curing method is based on actinically-induced step-growth polymerization. The invention also provides hydrogel contact lenses prepared from the method of the invention and fluid compositions for making hydrogel contact lenses based on the new lens curing method. In addition, the invention provide prepolymers capable of undergoing actinically-induced step-growth polymerization to form hydrogel contact lenses.Type: GrantFiled: December 12, 2007Date of Patent: August 23, 2011Assignee: Novartis AGInventors: Arturo Norberto Medina, Robert Scott, Dawn Alison Smith
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Publication number: 20110181833Abstract: There is provided a mono-(meth)acrylate functionalized hydrophilic silicone monomers containing a polyether with branched linking group, useful in making water absorbing silicone-hydrogel films for contact lens applications. This invention also provides homo-polymers and copolymers made from the mono-(meth)acrylate functionalized hydrophilic silicone monomers described herein. Also provided is a process for producing the monomers and polymers described herein and contact lenses produced from the same.Type: ApplicationFiled: October 5, 2009Publication date: July 28, 2011Inventors: Kendall Louis Guyer, Kenrick Martin Lewis, Sentihikumar Umapathy, Anubhav Saxena, Yi-Feng Wang
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Publication number: 20110178202Abstract: Azo compounds that block visible light are disclosed. These light absorbers are particularly suitable for use in intraocular lens materials.Type: ApplicationFiled: January 18, 2011Publication date: July 21, 2011Applicant: ALCON, INC.Inventor: Walter R. Laredo
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Publication number: 20110166248Abstract: The present invention provides a reactive hydrophilic copolymer consisting essentially of units formed by ethylenically unsaturated hydrophilic monomers and units of formula (I) or (II) formed by ethylenically unsaturated monomers having alkoxy silane functional groups in a random order: wherein the copolymer has a molecular weight of at least 50,000, and wherein R1, R2 and R3 can be the same or different and are independently selected from H or C1-3 alkyl; R is C1-3 alkyl; X, Y and Z can be the same or different and are independently selected from R? or OR?, provided that at least one of X, Y and Z is OR?; R? is H or C1-3 alkyl; and the equivalent ratio of the units formed by ethylenically unsaturated hydrophilic monomers to the units of formula (I) or (II) is within the range of 5/1 to 200/1. The present invention also provides silicone hydrogel compositions comprising the reactive hydrophilic copolymer of the present invention and ocular articles made therefrom.Type: ApplicationFiled: December 30, 2010Publication date: July 7, 2011Inventors: Yu-Fang HSU, Ching-Ping HUANG, Chia-Chang LIU
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Publication number: 20110146206Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.Type: ApplicationFiled: March 3, 2011Publication date: June 23, 2011Inventors: Jason K. Stanbro, Ivan M. Nunez, Jay F. Kunzler, Derek A. Schorzman
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Patent number: 7960602Abstract: The present invention provides a multilayer bandage, having a webbing for contacting a wound and a first membrane that has at least one water-insoluble polymer and is water-impervious. The present invention further provides methods for making the multilayer bandage, methods of using the multilayer bandage for accelerated wound healing, and kits having compositions of the present invention.Type: GrantFiled: December 30, 2005Date of Patent: June 14, 2011Assignee: Bayer Innovation GmbHInventors: Axel Thierauf, Iwer Baecker, Andreas Haisch
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Patent number: 7960447Abstract: The present invention relates to hydrophilic dicationic siloxane prepolymers with one polymerizable vinyl moiety instead of two polymerizable vinyl moieties, resulting in contact lenses and/or biomedical devices with reduced cross-link density and modulus without detracting from other properties.Type: GrantFiled: April 13, 2006Date of Patent: June 14, 2011Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Jay Kunzler
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Patent number: 7956135Abstract: The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.Type: GrantFiled: January 21, 2009Date of Patent: June 7, 2011Assignee: Novartis AGInventors: Thomas Hirt, Jacalyn Marie Schremmer, Troy Vernon Holland, Dieter Lohmann
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Patent number: 7942929Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.Type: GrantFiled: December 15, 2008Date of Patent: May 17, 2011Assignee: Bausch & Lomb IncorporatedInventors: Jeffrey G. Linhardt, Devon A. Shipp, Jay F. Kunzler