Abstract: A flowable liquid formulation for 3D printing is described. The formulation comprises from 0.1 to 25 wt. % radiopaque particles, wherein at least 50% by weight of the particles have a diameter of at most 100 nm. The formulation further comprises monomeric, oligomeric and/or polymeric precursors adapted for polymerization to form a solidified article. Also described is an article (100) formed by 3D printing, the article (100) comprising a first 3D printed region (110) having a first radiopacity and a second 3D printed region (120) having a second radiopacity, wherein the first radiopacity is greater than the second radiopacity. Also described is a method of forming the article (100).

Abstract: The present invention relates to a polymerizable composition, which comprises (a) at least one radically polymerizable oligomer, (b) at least one radically polymerizable monomer and (c) at least one initiator for the radical polymerization, characterized in that the radically polymerizable oligomer (a) is selected from the group consisting of aliphatic urethane (meth)acrylate oligomers, epoxy (meth)acrylate oligomers and polyether urethane (meth)acrylate oligomers, and the radically polymerizable monomer (b) is polyfunctional.

Abstract: To provide a dental composition wherein the acid buffering capacity can be attained and the acid resistance of the tooth substance can be improved while maintaining very high foul breath inhibition capacity. A dental composition including: ion sustained-release glass; and a carrier for supporting the ion sustained-release glass, wherein the ion sustained-release glass is fluoroaluminoborosilicate glass having a composition range of: 15% to 35% by mass SiO2; 15% to 30% by mass Al2O3; 5% to 20% by mass B2O3; 20% to 45% by mass SrO; 5% to 15% by mass F; and 0% to 10% by mass Na2O.

Abstract: Provided herein are high refractive index compositions with excellent light stability, and methods for the use thereof, as well as assemblies and articles prepared using invention formulations and methods.

Abstract: A radiopaque structure and an implanted medical instrument having the radiopaque structure. The radiopaque structure includes at least one radiopaque unit, and each radiopaque unit includes at least one radiopaque object. In at least one incidence direction of a light source, all the radiopaque objects in the radiopaque structure are divided into n regions according to the thickness in the incidence direction, and a projection area Sm of m regions of the n regions and an effective thickness dm of the m regions meet Sm?0.0136(dm)a?0, wherein ?0.95?a??0.85 and 1?m?n. The radiopaque structure has good or excellent visibility.

Abstract: The invention relates to a kit of parts for preparing a glass ionomer composition for dental use, the kit of parts comprising a Powder Part P and a Liquid Part L, Powder Part P comprising: acid-reactive inorganic filler, Liquid Part L comprising: water, complexing agent, polyacid, either the Powder Part P or the Liquid Part L or the Powder Part P and the Liquid Part L comprising non-aggregated nano-sized particles based on silica or alumina, the composition obtained by combining the components of Powder Part P and Liquid Part L before hardening comprising the components in the following amounts: non-aggregated nano-sized particles: from 0.1 to 15 wt.-%, acid-reactive filler in an amount from 50 to 75 wt.-%, polyacid: 7 to 20 wt.-%, complexing agent: 0.5 to 3 wt.-%, water: 5 to 18 wt.-%, wt.-% with respect to the weight of the whole composition.

Abstract: A radio opaque fiber, filament, and yarn is disclosed herein. The radio opaque fiber, filament, or yarn comprises a matrix (102) comprising a plurality of radio opaque material (104) and a first polymer (106), where the radio opaque material (104) is at least one of a radio opaque element, an alloy of the radio opaque element, and a compound of the radio opaque element, or a combination thereof, wherein the radio opaque element if of an atomic number greater than or equal to 29, and wherein the matrix (102) forms a unified flexible structure. The radio opaque fiber, filament, or yarn further comprises a carrier polymer (108) which binds the plurality of the matrix (102) and imparts spinnability to form the fiber, filament, and yarn.

Abstract: A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

Abstract: The invention relates to a hardenable multi-part liquid acrylic composition. The composition comprises a storage stable liquid first part, a storage stable liquid second part and optionally, a third or further liquid parts. The parts are operable to form a cement which hardens to a solid upon mixing of the parts together. The composition comprises an acrylic monomer component, an initiator component, acrylic polymer particles and a radiopacifying filler. The initiator component is present in an amount of effective to polymerize the acrylic monomer component upon being mixed and/or activated therewith. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the acrylic polymer particles in a liquid part.

Abstract: A method for assisting subchondral injection comprising creating a model of bone and soft tissue of a patient. At least one void is modeled in the bone from the model of bone and soft tissue. An injection site is identified from the model of bone and soft tissue and modeling of the at least one void. Data is output for guiding at least in the locating of the injection site and drilling of the bone to reach the void. A patient-specific jig for subchondral injection may be created based on the injection site location.

Abstract: A fracture mobility testing system is provided for use in surgical procedures for augmenting vertebral bodies having collapsed due to compression fractures. The testing system is utilized to determine if the cortical shell of the vertebral body has begun to heal over the fracture lines to the point at which height restoration is not possible. Depending on the feedback provided by the testing system, the surgeon may elect to proceed with any of a variety of known height restoration techniques if the fractured portions of the vertebral body are still mobile, or may elect for a simple vertebroplasty procedure without height restoration if the feedback from the testing system determines that the cortical outer portions of the fractured vertebral body have fused to one another to the point at which height restoration is no longer an option.

Abstract: Disclosed herein are acrylic and methacrylic acid ester-based polymeric materials containing as flexibilizing and brittleness reducing agents 1-60% of C4-C8 polyalkylene or polyalkyldiene compounds, preferably having a molecular weight of 300-2100, and the use of such materials in dentistry and medicine.

Abstract: A carrier composition for filling a tooth root canal, comprising a cross-linkable material.

Abstract: A dual-cure curable material kit comprising: (A) a radical-polymerizable monomer component; (B) a photopolymerization initiator component comprising (b1) an ?-diketone compound, (b2) an aliphatic tertiary amine compound having a tertiary amino group in which three saturated aliphatic groups are bonded to a nitrogen atom and one of the saturated aliphatic groups has an electron-withdrawing group as a substituent, and (b3) an s-triazine compound having a trihalomethyl group as a substituent, or a diaryliodonium salt compound; and a chemical polymerization initiator component (C) comprising (c1) an organic peroxide, and (c2) an N,N-di(hydroxyalkyl)-p-toluidine compound; which is packed separately at least in two packages so that the component (b2) and the component (b3) of the photopolymerization initiator component (B) are not packed together in a single package and the component (c1) and the component (c2) of the chemical polymerization initiator component (C) are not packed together in a single package.

Abstract: A curable dental composition comprising a monomer with a polyalicyclic structure element that can be used for filling and/or sealing of a root canal is described. Also described is a composition useful as a dental material and a method for preparing such a composition. New polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a dental composition, and the use of the new monomers in a dental composition are also described.

Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.

Abstract: A radio-opaque marker for medical implants comprising between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements selected from the consisting of I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent of residual components, the aforementioned components amounting to 100 weight percent.

Abstract: This invention relates to a composition resulting from the mixture of a solid phase, comprising at least one calcium derivative powder in association with at least one radioopacifier and at least one polymer and optionally at least one non-radioopaque filler, all in powder form; and aqueous phase comprising water, at least one water-reducing agent, and at least one set accelerator; the ratio of solid phase to liquid phase ranging from 1.0 to 2.5, preferably from 1.5 to 2.2, more preferably from 2 to 2.15; said composition having a compressive strength of less than 40 MPa, preferably ranging from 1 to 15 MPa, preferably ranging from about 3 to about 12 MPa; this invention also relates to a kit and a method for the manufacture of the composition, and to a method for treating or retreating a canal root.

Abstract: Dental compositions and dental products having a resin derived from a cyclic diol such as 2,2,4,4-tetramethyl-1,3-cyclobutanediol.

Abstract: A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.

Abstract: Colorless dental compositions for restoring the enamel layer of a tooth are disclosed. The colorless enamel compositions are combined with pigmented dentin compositions to provide a true color match and natural esthetics. Methods that utilize the compositions in placement/build-up techniques in direct restorations are also disclosed.

Abstract: The present invention relates to a solid composition comprising: a calcium silicate powder, a set accelerator in the form of a powder, a reinforcing filler in a solid form, a radio-opacifying agent in a solid form, at least one complementary ingredient selected from solid fibers or solid porous fillers, optionally a water-reducing agent in a solid form, and optionally solid pigments. The present invention also relates to a kit of parts for the preparation of a composition suitable for use in dentistry comprising in a first container a solid phase including the solid composition according to the invention, and in a second container an aqueous phase. The present invention also relates to a kit of parts for the preparation of a composition suitable for use in dentistry comprising a container, said container comprising at least two cells, the first cell comprising a solid phase including the solid composition of the invention and the second cell comprising an aqueous phase.

Abstract: The present invention relates to fiber-reinforced composites, particularly application-oriented composites useful in dental and medical applications/appliances, such as fiber reinforced dental composites, and to a method for the manufacture thereof. Particularly the invention concerns random glass fiber-reinforced restorative composite resins with semi-interpenetrating polymer network matrix and their use in dental applications like cavity fillings, core composites, provisional and semi-permanent crown and bridge composite, cements and adhesives.

Abstract: A dental appliance comprising a hard, shaped body having at least one portion comprising a polymerized blend of: From 0% to about 50% of an uncrosslinked polymer capable of dissolving in component; From about 0% to 50% of a monofunctional polymerizable monomer; From about 0% to 40% of a highly crosslinked polymer in the form of ground particles having average diameters up to about 500 microns; From about 0% to 50% of a crosslinked polymer in the form of discrete particles having average diameters up to about 500 microns and being easily swellable by said monomer; and From about 5% to about 35% of a di- or polyfunctional crosslinking agent.

Abstract: A dental composition comprising: a) about 1 to about 80% by weight of particulate material including: (i) calcium silicate, calcium aluminate, tetracalcium aluminoferrite, calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, or mixtures thereof; and b) about 1 to about 50% by weight liquid carrier including: (i) water-soluble polymer, (ii) surfactant, the surfactant is selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and sarcosinates, and mixtures thereof; and (iii) water; wherein the particulate and liquid carrier being mixed together to form a hydrate gel material that can harden.

Abstract: A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

Abstract: To provide a dental hydraulic temporary sealing material composition setting faster than conventional composition, excellent adhesiveness with cavity, and extremely good operativity of filling in an oral cavity, the dental hydraulic temporary sealing material composition includes calcium sulfate, a vinyl acetate resin, an inorganic filler, alcohols having a boiling point of 110° C. or more, and a nonionic surfactant, whereby water on a cavity can adhere, without being repelled, to a paste surface due to hydrophilic effect between an organic solvent having proper hydrophilicity and the nonionic surfactant, the water can permeate and diffuse rapidly and stably through the inside of the paste by the hydrophilic effect so as to set faster than conventional composition, and since the hydrophilic effect is effective for adhesiveness with cavity, filling property in an oral cavity becomes extremely good.

Abstract: A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

Abstract: A bone cement composition which contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 ?m, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 ?m, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles, and a part or a whole of the small-diameter (meth)acrylate polymer particles are contained in the form of aggregates having an average particle diameter of 30 to 50 ?m.

Abstract: The invention refers to an artificial bone mineral substitute material which comprises at least one ceramic and at least one water soluble non-ionic X-ray contrast agent. The invention refers to a composition for producing the same, which further comprises an aqueous liquid, as well as the use of the composition as a X-ray contrast medium.

Abstract: The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.

Abstract: A cement for dental use, containing a first agent and a second agent, wherein both of the first agent and the second agent contain a polymerizable monomer (a) and a filler (b), wherein the first agent and/or the second agent further contains a photopolymerization initiator (c), wherein further as a chemical polymerization initiator (d), either one of the first agent and the second agent contains an oxidizing agent (f) and the other contains a reducing agent (g), the oxidizing agent (f) and the reducing agent (g) constituting a redox polymerization initiator, wherein the photopolymerization initiator (c) contains an ?-diketone, and the photopolymerization initiator (c) is contained in a total amount of from 0.010 to 0.100 parts by weight, based on 100 parts by weight of the total amount of the polymerizable monomer (a), wherein the chemical polymerization initiator (d) is contained in a total amount of from 0.

Abstract: A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.

Abstract: The invention relates to a system for preparing a polymerized bone cement, including two components reacting with each other when they are mixed to form a solid polymer material. The first component may include a biocompatible acrylic polymer and an initiator capable of initiating a polymerization reaction. The second component may include a monomer capable of dissolving an acrylic polymer, a polymerization activator and a polymerization inhibitor, system in which the second component also includes a biocompatible acrylic polymer dissolved in said monomer, identical or different from the polymer of the first component with an average molar mass greater than 1,000,000 g/mol and a residual initiator content of less than 0.1% to form a gel with determined viscosity. Another object of the invention is a composition designed to constitute the second component of as system used to prepare such cement.

Abstract: Provided herein are uncured dental composites suitable for, among other things, filling cavities in teeth.

Abstract: The invention is directed to an improved dental composition useful in the repair of cavities, apex repairs, root perforations and root canals. Disclosed is a dental composition and dental composition additive which have improved handling characteristics, for example improved viscosity and setting time. The addition of effective amounts of a modified cellulose and calcium chloride to available dental repair compounds, such as mineral trioxide compound, results in the improved dental composition without affecting the other characteristics of the dental repair compound.

Abstract: The invention relates to a dental composition comprising a monomer or mixture of monomers represented by the following structure (1) with 1,2R independently selected from H, alkyl (e.g. CH3C2H5), and Phenyl, 3,4R independently selected from H, alkyl (e.g. CH3), and halogen (Cl, Br, F), 5R independently selected from H, alkyl (e.g. CH3), m, n=1, 2 and x+y=2 to 10, with the proviso that if m=n=2, than x+y=2 and if m=n=1, than x+y=4 to 10. The invention also relates to a process for producing the monomer or mixture of monomers and the use thereof especially as dental composition.

Abstract: An easily removable dental curable composition which prevents the fall or leakage of a temporary prosthetic appliance or a root canal filling material which is easily removed by bonding and adhering it to tooth, shows such high flowability that its operation is easy, has a long working time and excellent X-ray contrast properties and sealability and can be easily removed as required, and a filling kit. The dental curable composition comprises (A) a polymerizable monomer mixture containing a polymerizable monomer having an acid group in the molecule and (B) a polymerization initiator, wherein the component (A) contains (A?) a long-chain polymerizable monomer having a structure with a chain length of 17 or more atoms and/or the composition further comprises (D1) a soft resin material.

Abstract: The present invention is directed to a medical device, specifically a prosthesis which utilizes a novel class of blends between biodegradable polymers and bioceramics for medical device applications allowing one to capitalize on the biodegradable nature of these two distinct materials while enhancing the strength of these devices through the addition of various amounts of bioactive ceramic and glasses to biodegradable polymers. The blend may be fabricated into a medical device such as a stent or a distal protection device, and may incorporate various agents to enhance radioapacity and/or pharmacological function. In addition, the blend may be used as a coating to a medical device.

Abstract: A bone cement comprising a first component and a second component, wherein contacting the first component and the second component produces a mixture which attains a high viscosity an initial period and the viscosity of the mixture remains relatively stable for a working time of at least 5 minutes after the initial setting period, and the mixture is suitable for in-vivo use.

Abstract: Polymerizable dental material which contains (a) at least one radically polymerizable compound according to the general formula I (b) initiators for radical polymerization; and (c) filler.

Abstract: Disclosed are photopolymerizable compositions suitable for uses such as dental composite resins, and that comprise (A) a radical-polymerizable monomer, (B) a photopolymerization initiator that comprises (B1) an ?-diketone compound, (B2) a photoacid generating agent, (B3) an aromatic amine compound, and (C) an organic filler containing a phthalate ester fluorescent agent.

Abstract: The present invention relates to bone cements and, more particularly, to acrylic-based orthopedic bone cements, their use in spinal applications, and methods for making the same. An embodiment of the present invention provides a method of grafting PMMA brushes on cross-linked PMMA nanospheres comprising at least one of the following steps: performing a hydrolysis reaction of surface methyl ester groups of said cross-linked PMMA nanospheres to form surface carboxylic acid groups of said cross-linked PMMA nanospheres; forming a 2-aminoethyl acrylate compound; coupling said surface carboxylic acid groups of said cross-linked PMMA nanospheres with said 2-aminoethyl acrylate compound to form a coupled compound with an initiating site; and grafting said PMMA brushes onto said initiating site.

Abstract: A filler which is surface-modified with a compound of the formula [(PG)-R1—Z]n—SP—[Y—R2-(AG)]m is particularly suitable for use in dental materials, for the preparation of adhesives, coatings and composites.

Abstract: A method for augmenting a tissue including introducing into the tissue a first thermoplastic material at a first condition; treating the first thermoplastic material to achieve a second condition that includes an at least partially crystalline skin; and introducing a second material into the tissue whereby the first thermoplastic material and the second material are contained by the at least partially crystalline skin. Also a method of fracture reduction in a tissue including exposing to gamma radiation a mass of polycaprolactone characterized by a first shape; heating the mass of irradiated polycaprolactone above its melting temperature; introducing the heated mass of polycaprolactone into the tissue annulus to deform it from the first shape; allowing the material to return to the first shape.

Abstract: The invention relates to an initiator system comprising a diarylalkylamine compound and a sensitizing agent. The invention also relates to a hardenable composition comprising the initiator system. The invention further relates to the use of the initiator system for initiating the hardening process of a hardenable composition being selected from cationically curing composition(s) and/or radically curing composition(s) or a mixture thereof. The initiator system and the hardening composition can be used in various fields, including the dental and orthodontic area.

Abstract: This invention relates to a composition resulting from the mixture of a solid phase, comprising at least one calcium derivative powder in association with at least one radioopacifier and at least one polymer and optionally at least one non-radioopaque filler, all in powder form; and aqueous phase comprising water, at least one water-reducing agent, and at least one set accelerator; the ratio of solid phase to liquid phase ranging from 1.0 to 2.5, preferably from 1.5 to 2.2, more preferably from 2 to 2.15; said composition having a compressive strength of less than 40 MPa, preferably ranging from 1 to 15 MPa, preferably ranging from about 3 to about 12 MPa; this invention also relates to a kit and a method for the manufacture of the composition, and to a method for treating or retreating a canal root.

Abstract: The invention features a dental composition containing a polycyclic aromatic compound, such as 2-ethyl 9,10-dimethoxy anthracene (EDMOA), in an amount that provides the composition with fluorescence mimicking that of natural teeth.

Abstract: This invention relates to polymerizable compositions comprising a salt of a barbituric acid derivative. The compositions are typically shelf-life stable and may be polymerized through mixing of an acidic component with the salt of a barbituric acid derivative.

Abstract: The present invention provides bioactive bone cements that not only have sufficient radiopacity, low physiological toxicity, and requisite mechanism strength, but also promote local bone in-growth. The bone cement utilizes strontium salts as radiopacifiers, and comprises a powder component and a liquid component. In an embodiment, the powder component comprises a strontium salt, poly(methyl methacrylate) (PMMA), and a polymerization initiator; and the liquid component comprises methyl methacrylate (MMA) as reactive monomers and a polymerization accelerator.