Dextrin Or Derivative Patents (Class 536/103)
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Publication number: 20090226571Abstract: The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.Type: ApplicationFiled: September 6, 2006Publication date: September 10, 2009Applicant: BASF SEInventors: Stephan Freyer, Markus Pompejus, Oskar Zelder, Markus Lohscheidt, Matthias Boy, Edzard Scholten
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Patent number: 7582154Abstract: The present invention includes methods for preparing polyol products including a method of making a free-flowing granular product comprising: a) charging hydrogenated starch hydrolysate to an agglomerator; b) adding polyol syrup to the maximum loading capacity of the hydrogenated starch hydrolysate; and c) adding polyol crystals in an amount sufficient to dry the product. The present invention also includes compositions comprising polyol products for use in pharmaceuticals, nutraceuticals, foods, such as frozen dairy and bakery items, and confections.Type: GrantFiled: July 28, 2005Date of Patent: September 1, 2009Assignee: Corn Products International, Inc.Inventors: Cecil W. Propst, Ronald C. Deis
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Publication number: 20090214446Abstract: Cyclodextrin inclusion complexes, guest stabilizing systems, and methods for preparing and using the same. Some embodiments of the present invention provide a method for making a guest stabilizing system. The method can include mixing cyclodextrin, a solvent and a guest to form a cyclodextrin inclusion complex. The method can further include adding uncomplexed cyclodextrin to the cyclodextrin inclusion complex to form a guest stabilizing system. Some embodiments of the present invention provide a method for making a beverage that can include mixing uncomplexed cyclodextrin, a guest and a solvent to form a beverage.Type: ApplicationFiled: April 5, 2006Publication date: August 27, 2009Applicant: CARGILL, INCORPORATEDInventor: Kenneth J. Strassburger
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Patent number: 7569557Abstract: Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and ?-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity.Type: GrantFiled: December 4, 2006Date of Patent: August 4, 2009Assignee: Bayer Schering Pharma AGInventors: Thomas Backensfeld, Wolfgang Heil, Ralph Lipp
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Publication number: 20090130155Abstract: The present invention provides a formulation characterised by the simultaneous presence in cyclodextrin based supramolecular complexes, of two components, one of which possesses insecticidal, acaricidal, fungicidal, snailcidal or vermicidal activity and the other possesses an activity synergistic with the first, enhancing its effectiveness. The biologically active substance is chosen from the following classes of chemical products: carbamates, organophosphates, thioureas, pentatomic or hexatomic heterocycles in which 1, 2 or 3 nitrogen atoms are present. The synergistic substance can be chosen from components containing at least one aromatic or non aromatic carbocyclic ring, such as piperonyl butoxide, sesamol, verbutin or MGK 264. For the same dose, the activity of the present formulations is greater than that of the mixture of the two active components alone or separately complexed with cyclodextrin.Type: ApplicationFiled: April 21, 2006Publication date: May 21, 2009Applicant: ENDURA S.P.A.Inventors: Oreste Piccolo, Valerio Borzatta, Giovanna Delogu, Elisa Capparella, Cristina De Candia, Carlotta Gobbi, Giovanna Di Blasi
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Publication number: 20090118492Abstract: There is provided batch methods of making cyclopropene complex involving mixture comprising (i) one or more molecular encapsulating agent and (ii) solvent, wherein the ratio of the amount of said (i) to the amount of said (ii) is higher than the solubility of said molecular encapsulating agent in said solvent. There is also provided continuous methods of making cyclopropene complex in which the ratio of the rate of addition of molecular encapsulating agent to the rate of addition of solvent is higher than the solubility of said molecular encapsulating agent in said solvent.Type: ApplicationFiled: October 30, 2008Publication date: May 7, 2009Inventor: Richard Martin Jacobson
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Publication number: 20090054375Abstract: Certain exemplary embodiments can provide a composition of matter comprising a solid form of chlorine dioxide complexed with a cyclodextrin. When stored, a concentration of the chlorine dioxide in the composition of matter can be retained, with respect to an initial concentration of chlorine dioxide in said composition of matter, at, for example, greater than 12% for at least 14 days. Certain exemplary embodiments can provide a method comprising releasing chlorine dioxide from a solid composition comprising chlorine dioxide complexed with a cyclodextrin.Type: ApplicationFiled: July 31, 2008Publication date: February 26, 2009Inventors: Ken Harrison, Nick Blandford
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Patent number: 7494761Abstract: A photoresist film is formed on an object layer of a semiconductor device by coating the object layer with a photoresist composition including about 7 percent to about 14 percent by weight of a cyclodextrin derivative, about 0.1 percent to about 0.5 percent by weight of a photoacid generator, and a remainder of an organic solvent. The cyclodextrin derivative includes a ?-cyclodextrin moiety and at least one alkyl carbonate group.Type: GrantFiled: September 11, 2007Date of Patent: February 24, 2009Assignee: Samsung Electronics Co., Ltd.Inventors: Hyo-Jin Yun, Young-Gil Kwon, Young-Ho Kim, Hong Lee, Do-Young Kim
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Publication number: 20090029020Abstract: Cyclodextrin inclusion complexes and methods for preparing and using the cyclodextrin inclusion complexes. A method for preparing a cyclodextrin inclusion complex can include dry blending cyclodextrin, an emulsifier and a thickener to form a dry blend, and mixing a solvent and a guest with the dry blend to form a mixture comprising a cyclodextrin inclusion complex. In some embodiments, the mixture can be dried to form a dry powder or emulsified to form an emulsion. The dry powder or the emulsion can be used in a variety of applications (e.g., beverages, food products, chewing gums, dentifrices, candy, flavorings, fragrances, pharmaceuticals, nutraceuticals, cosmetics, agricultural products, photographic emulsions, waste stream systems, and combinations thereof).Type: ApplicationFiled: April 5, 2006Publication date: January 29, 2009Applicant: CARGILL, INCORPORATEDInventor: Kenneth J. Strassburger
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Publication number: 20090023912Abstract: Water-soluble, UV-absorbing and/or fluorescing compound having an isoelectric point greater than 10, can be obtained using molecules chosen from the group of molecules consisting of those containing at least one secondary alcohol OH group with a PKa value greater than 10 and at least one amino group with a pKb value smaller than 5, those containing at least one primary alcohol OH group and at least one secondary alcohol OH group with respective PKa values greater than 10 and at least one amino group with a pKb value smaller than 5 or a quaternary ammonium group, and those containing at least two secondary alcohol OH groups with respective pKa values greater than 10 and at least one amno group with a pKb value smaller than 5 or a quaternary ammonium group; and having at least one UV absorbing group or at least one fluorescing group or a combination thereof. The invention includes methods for producing such compounds.Type: ApplicationFiled: April 22, 2005Publication date: January 22, 2009Inventors: Gyula Vigh, Sanjiv K. Lalwani, Brent Busby, Kingsley Nzeadibe, Helen C. Fleisher, Evan E. Shave
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Publication number: 20090012284Abstract: The present invention relates to a process for the preparation of an inclusion compound of piroxicam with ?-cyclodextrin by spray-drying, applicable on a pilot or industrial scale. The obtained product have optimal physico-chemical characteristics as well as technological and biopharmaceutical properties and it is suitable for preparing solid pharmaceutical compositions for the oral administration.Type: ApplicationFiled: July 26, 2005Publication date: January 8, 2009Applicant: Chiesi Farmaceutici S.p.A.Inventors: Roberto Pighi, Soren Fjordgaard Andersen
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Publication number: 20090012041Abstract: The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma.Type: ApplicationFiled: September 30, 2005Publication date: January 8, 2009Inventors: Didier Cataldo, Brigitte Evrard, Agnes Noel, Jean-Michel Foidart
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Publication number: 20090012042Abstract: Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. “n” represents the average substituent degree of hydroxypropyl groups; “m” represents the average substituent degree of sulfobutyl groups; “n+m=z” is the gross average substituent degree, in which n is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; m is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; and the gross average substituent degree z is a random integer chosen from 2, 3, 4, 5, 6, 7, 8, 9, 10. The present invention shows low haemolysis and low toxicity.Type: ApplicationFiled: November 28, 2005Publication date: January 8, 2009Applicant: NANJING NORMAL UNIVERSITYInventors: Yong Ren, Xueqin Ma, Shuqin Yu, Xiaodong Sun
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Patent number: 7473776Abstract: The invention relates to soluble hydrogenated starch derivatives containing nondigestible dietary fiber, characterized in that they have an ICUMSA coloration value reduced by at least 50%, and a reducing sugar content reduced by at least 30%, and to their method of preparation.Type: GrantFiled: October 28, 2002Date of Patent: January 6, 2009Assignee: Roquette FreresInventor: Patrick Fuertes
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Publication number: 20090005554Abstract: Disclosed are a method for the reduction of an oligosaccharide mixture and an oligosaccharide mixture prepared thereby. In accordance with the disclosed invention, a mixture of oligosaccharides having a given DP profile is reduced to a DE of essentially zero by catalytically hydrogenating the mixture under reaction conditions sufficient to preserve the DP profile of the mixture, which reaction conditions typically include a reaction temperature ranging from about 50° C. to about 150° C. and a reaction pressure ranging up to about 1500 psi. Surprisingly, when the mixture is a malto-oligosaccharide mixture, the reduced mixture will have a superior color-fastness and thermal stability as compared to a similar unreduced mixture of malto-oligosaccharides, and also low reactivity towards nitrogen-containing species.Type: ApplicationFiled: June 24, 2008Publication date: January 1, 2009Applicant: Grain Processing CorporationInventors: Frank W. Barresi, Richard L. Antrim
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Publication number: 20080318898Abstract: The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-?-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.Type: ApplicationFiled: August 28, 2008Publication date: December 25, 2008Applicant: Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.Inventors: Zhan-qi Niu, Kai Zhao, Wen-juan Liu, Gui-rong Zhou, Chao Liu, Rong-duan Wang, Hong-zhong Yuan, Wen-min Guo, Sui-chao Yan, Min Bai
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Patent number: 7459549Abstract: Disclosed herein is a composition for preparing a nanoporous material. The composition comprises i) a cyclodextrin derivative, ii) a thermostable matrix precursor, and iii) a solvent for dissolving the components i) and ii). The composition enables the preparation of a low dielectric constant film in which nanopores with a size of 20 ? or less are uniformly distributed.Type: GrantFiled: December 3, 2004Date of Patent: December 2, 2008Assignee: Samsung Corning Co., Ltd.Inventors: Jin Heong Yim, Byoung Ki Choi, Duk Keun An
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Patent number: 7423027Abstract: Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise.Type: GrantFiled: February 18, 2005Date of Patent: September 9, 2008Assignee: Abbott LaboratoriesInventors: Chron-Si Lai, JoMay Chow, Bryan W. Wolf
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Publication number: 20080214760Abstract: A terminating agent and a method for preparing an anionic polymer are provided. The terminating agent includes a carbohydrate, which is a solid substantially insoluble in a solvent and is used for terminating an anionic polymerization of a polymer. Another aspect of the method includes steps which provide an initiator for initiating an anionic polymerization, adding a terminating agent for terminating the anionic polymerization and forming a complex, wherein the terminating agent is a carbohydrate, and an alkali metal ion is removed by a solid-liquid separation process.Type: ApplicationFiled: January 9, 2008Publication date: September 4, 2008Applicant: TSRC CORPORATIONInventors: CHI-CHEN HSIEH, CHIH-KUANG TSAI, TSUNG-YUAN WANG
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Publication number: 20080214018Abstract: A reactive cyclodextrin derivative or a reactive glucose derivative is used as a template derivative for forming an ultra-low dielectric layer. A layer is formed of the reactive cyclodextrin derivative or the reactive glucose derivative capped with Si—H and then cured in an atmosphere of hydrogen peroxide to form the ultra-low dielectric layer.Type: ApplicationFiled: December 27, 2007Publication date: September 4, 2008Inventors: Sung Kyu MIN, Ja Chun KU, Chan Bae KIM, Sang Tae AHN, Chai O. CHUNG, Hyeon Ju AN, Hyo Seok LEE, Eun Jeong KIM
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Publication number: 20080213384Abstract: A description is given of substantially spherical nanosponges which can be obtained by crosslinking cyclodextrins and their by-products with organic carbonates as crosslinkers and ultrasounds without a solvent.Type: ApplicationFiled: June 22, 2005Publication date: September 4, 2008Inventors: Francesco Trotta, Roberta Cavalli, Wander Tumiatti, Orfeo Zerbinati, Carlo Roggero, Roberto Vallero
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Publication number: 20080206823Abstract: Provided is a method of making at least one inclusion complex comprising a useful complexant and a cyclodextrin, wherein said method comprises the steps of (a) making said cyclodextrin, and (b) mixing said cyclodextrin with said useful complexant, wherein said method is conducted without purifying said cyclodextrin. Also provided is a composition useful for manufacturing inclusion complexes comprising water, at least one starch, at least one enzyme, and at least one useful complex ant.Type: ApplicationFiled: February 15, 2008Publication date: August 28, 2008Inventors: Richard Martin Jacobson, Willie Lau
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Patent number: 7417109Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: August 7, 2006Date of Patent: August 26, 2008Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
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Patent number: 7405293Abstract: Disclosed are a method for the reduction of an oligosaccharide mixture and an oligosaccharide mixture prepared thereby. In accordance with the disclosed invention, a mixture of oligosaccharides having a given DP profile is reduced to a DE of essentially zero by catalytically hydrogenating the mixture under reaction conditions sufficient to preserve the DP profile of the mixture, which reaction conditions typically include a reaction temperature ranging from about 50° C. to about 150° C. and a reaction pressure ranging up to about 1500 psi. Surprisingly, when the mixture is a malto-oligosaccharide mixture, the reduced mixture will have a superior color-fastness and thermal stability as compared to a similar unreduced mixture of malto-oligosaccharides, and also low reactivity towards nitrogen-containing species.Type: GrantFiled: August 29, 2003Date of Patent: July 29, 2008Assignee: Grain Processing CorporationInventors: Frank W. Barresi, Richard L. Antrim
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Publication number: 20080118957Abstract: There is disclosed a process for preparing liquid maltodextrin having a D.E. of about 5 to less than about 20, Also disclosed are liquid maltodextrins having a D.E. of about 9 to about 15.Type: ApplicationFiled: October 21, 2005Publication date: May 22, 2008Inventors: Francois Deleyn, Christopher Aiken, Frank Derez, David Mauro, Dirk Provoost, Marie-Odile Stalin, Bruno Vanhemelrijck
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Publication number: 20080112905Abstract: The invention relates to complexes of certain flavonoid derivatives, of the formula (1), where R1 and R2 are selected from H and OR11, where OR11 stands, independently of one another, for OH, straight-chain or branched C1- to C20-alkoxy groups, straight-chain or branched C3- to C20-alkenyloxy groups, straight-chain or branched C1- to C20-hydroxyalkoxy groups, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C3- to C10-cycloalkoxy groups and/or C3- to C12-cycloalkenyloxy groups, where the rings may in each case also be bridged by —(CH2)n— groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, with the proviso that at least one radical from R1 and R2 stands for OR11, and R3 to R10 may be identical or different and stand, independently of one another, for radicals which are substantially inert with respect to the UV properties, to compositions which comprise such complexes, to corresType: ApplicationFiled: November 3, 2005Publication date: May 15, 2008Applicant: MERCK PATENT GMBHInventors: Christophe Carola, Anne Toullec, Herwig Buchholz
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Publication number: 20080070157Abstract: A photoresist film is formed on an object layer of a semiconductor device by coating the object layer with a photoresist composition including about 7 percent to about 14 percent by weight of a cyclodextrin derivative, about 0.1 percent to about 0.5 percent by weight of a photoacid generator, and a remainder of an organic solvent. The cyclodextrin derivative includes a ?-cyclodextrin moiety and at least one alkyl carbonate group.Type: ApplicationFiled: September 11, 2007Publication date: March 20, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Hyo-Jin YUN, Young-Gil KWON, Young-Ho KIM, Hong LEE, Do-Young KIM
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Publication number: 20080045477Abstract: A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(-tricyclo[3.3.1.13,7]decyl]-1,3,5-triazines where the aryl group is a substituted or unsubstituted phenyl, or naphthyl-group, as pharmaceutically accepted salts or as free bases. The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times each one, and in various positions of the phenyl group. The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them. The invention refers to new and prototype compounds inhibiting the proliferation of unwanted cells that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthesis and the method of synthesis of the above mentioned compounds.Type: ApplicationFiled: June 14, 2002Publication date: February 21, 2008Inventors: Ekaterini Antoniadou-Vyza, Polyvxeni Tsitsa, Christos Roussakis
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Patent number: 7307176Abstract: The present invention relates to a method for producing a 2-hydroxypropyl-beta-cyclodextrin inclusion complex of taxol, said 2-hydroxypropyl-beta-cyclodextrin having a degree of substitution of 0.4 to about 0.9, wherein the method comprises admixing the 2-hydroxypropyl-beta-cyclodextrin with taxol at a molar ratio of 1-1000 times with respect to taxol. A second aspect of the invention relates to a method for improving the solubility of taxol, said method comprising: (i) dissolving taxol in ethanol; (ii) dissolving 2-hydroxypropyl-beta-cyclodextrin, having a degree of substitution of 0.4 to about 0.9, in water; (iii) admixing the solution from step (i) with the solution from step (ii) and stirring, shaking or heating. A third aspect of the invention provides a 2-hydroxypropyl-beta-cyclodextrin inclusion complex of taxol, wherein said 2-hydroxypropyl-beta-cyclodextrine has a degree of substitution of 0.4 to about 0.9.Type: GrantFiled: November 15, 2002Date of Patent: December 11, 2007Assignee: Vianex S.A.Inventor: Konstantinos Anastasios Kagkadis
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Patent number: 7285157Abstract: An air-filter for a circulating and/or recirculating air system using a filter medium containing a microbiologically effective amount of a polymeric biguanide or salt thereof. Also claimed is a method for reducing odors and/or air-borne micro-organisms in a circulating or recirculating air system using the air-filter, and a method for protecting an air-filter medium against microbial degradation by incorporating in, or on, the medium a microbiologically effective amount of a polymeric biguanide or salt thereof.Type: GrantFiled: July 26, 2000Date of Patent: October 23, 2007Assignee: Arch UK Biocides LimitedInventors: Helen Dukes, John David Payne
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Patent number: 7271259Abstract: A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclodextrins (CD) or calixarenes (CX).Type: GrantFiled: May 6, 2003Date of Patent: September 18, 2007Assignee: Northwestern UniversityInventors: Joseph B. Lambert, Chunqing Liu
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Patent number: 7259153Abstract: The present invention is directed to pharmaceutical compositions containing crystalline methylated cyclodextrins, which enhance the solubility of the pharmaceutically active agent or agents of the formulation.Type: GrantFiled: February 2, 2004Date of Patent: August 21, 2007Assignee: Supernus PharmaceuticalsInventor: Rong-Kun Chang
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Patent number: 7211662Abstract: The invention relates to soluble highly branched glucose polymers having a reducing sugar content of less than 1%, characterized in that they have a level of ?-1,6 glucoside bonds greater than 10%, preferably of between 12 and 30%, a Mw value of between 0.35×105 and 2×105 daltons, and an osmolality having a value of between 1 and 15 mOsm/kg. The invention also relates to their method of production and their applications in the Paper-Carton, Textiles, Cosmetics, and particularly Pharmaceutical and Food industries, and still more particularly in the fields of enteral and parenteral nutrition, peritoneal dialysis as a glycemia inhibiting and/or regulating agent, as an energy source during physical activities and as a digestion regulating agent.Type: GrantFiled: February 28, 2005Date of Patent: May 1, 2007Assignee: Roquette FreresInventors: Daniel Backer, Marie-Helene Saniez
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Patent number: 7202231Abstract: Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a ?-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted pathogen to or from a subject by contacting the pathogen or cells susceptible to the pathogen in the subject with a pharmaceutical composition containing a ?-cyclodextrin also are provided. Accordingly, pharmaceutical compositions, which include 1) a ?-cyclodextrin, which is in an amount that blocks passage of the pathogen through lipid rafts in the membrane of a cell susceptible to the pathogen, and 2) a contraceptive, an agent for treating a sexually transmitted disease, a lubricant, or a combination thereof, are provided, as are composition formulated from a solid substrate that contains an amount of ?-cyclodextrin useful for reducing the risk of transmission of a sexually transmitted pathogen.Type: GrantFiled: December 28, 2004Date of Patent: April 10, 2007Assignee: The Johns Hopkins University School of MedicineInventor: James E. Hildreth
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Patent number: 7202233Abstract: A pharmaceutical composition an inclusion complex and methods for treating patients and preparing said complex disclosed for transmucosal delivery comprising an inclusion complex of (a) alprazolam and (b) a water soluble 2-hydroxypropyl-beta-cyclodextrin, and a pharmaceutically acceptable carrier therefor, wherein all the alprazolam is present in ring-closed form.Type: GrantFiled: June 3, 2005Date of Patent: April 10, 2007Assignee: Farmarc Nederland BVInventor: Lawrence John Penkler
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Patent number: 7186702Abstract: The present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally along with other anti-leishmanial agent(s) and/or pharmaceutically acceptable additives, and a method thereof, wherein the said method reduces the cholesterol levels of the plasma membrane of the infected host cells by about 50%.Type: GrantFiled: May 31, 2005Date of Patent: March 6, 2007Assignee: Council of Scientific and Industrial ResearchInventors: Amitabha Chattopadhyay, Rentala Madhubala
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Patent number: 7182941Abstract: Methods of treating an inanimate object or inanimate surface which has malodor impression to reduce the malodor impression comprise the step of contacting the inanimate object or inanimate surface with an effective amount of a composition for reducing malodor impression comprising: (a) from about 0.1% to about 1%, by weight of the composition, of perfume; (b) cyclodextrin; (c) aerosol propellant; (d) optionally, solubilizing aid; and (e) aqueous carrier. The compositions used in the methods are essentially free of any material that would soil or stain fabric. The inanimate surface treated via the present methods is preferably fabric.Type: GrantFiled: August 16, 2002Date of Patent: February 27, 2007Assignee: The Procter & Gamble CompanyInventors: Toan Trinh, Jerome Paul Cappel, Philip Anthony Geis, Judith Ann Hollingshead, Mark Lee McCarty, Susan Schmaedecke Zwerdling
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Patent number: 7166226Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.Type: GrantFiled: January 28, 2005Date of Patent: January 23, 2007Assignee: Dionex CorporationInventors: L. Andy Woodruff, Andrei V. Bordunov, Christopher A. Pohl
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Patent number: 7163931Abstract: Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and ?-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity.Type: GrantFiled: April 11, 2005Date of Patent: January 16, 2007Assignee: Schering AktiengesellchaftInventors: Thomas Backensfeld, Wolfgang Heil, Ralph Lipp
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Patent number: 7157446Abstract: A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.Type: GrantFiled: April 20, 2004Date of Patent: January 2, 2007Assignee: Bristol Myers Squibb CompanyInventors: Anne Marie Smith, Michael Cucolo, Munir N. Nassar
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Patent number: 7115586Abstract: The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with ?-cyclodextrin in an aqueous complexation medium comprising ?-cyclodextrin and a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with ?-cyclodextrin and its inclusion complexes.Type: GrantFiled: October 18, 2002Date of Patent: October 3, 2006Assignee: Decode Genetics EHF.Inventor: Thorsteinn Loftsson
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Patent number: 7109324Abstract: A process for chemically bonding an odor-encapsulating agent to textiles includes reacting a cyclodextrin with a cross-linking agent capable of forming ether bonds with the cyclodextrin and with the textile material, and curing the textile material treated with a mixture of the cyclodextrin and cross-linking agent. Preferably, the cross-linking agent is imidazolidone, which forms an ether bond with a hydroxyl group on the cyclodextrin and with a hydroxyl group. In textile materials containing cellulose, imidazolidone forms an ether bond with a hydroxyl group on the cellulose. An active agent can be complexed with the cyclodextrin for release. Textiles formed by such a process can comprise an article of clothing adapted to trap odors emanating from a wearer.Type: GrantFiled: February 7, 2005Date of Patent: September 19, 2006Assignee: Dan River, Inc.Inventors: Donald Eugene Todd, David Alan Brown
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Patent number: 7105500Abstract: A process for the antimicrobial treatment of fiber materials, comprising applying to the fiber material an inclusion complex of a fiber-reactive cyclodextrin derivative with an antimicrobial agent selected from the group consisting of (a) halogeno-o-hydroxydiphenyl compounds or non-halogenated hydroxydiphenyl ether compounds; (b) phenol derivatives; (c) benzyl alcohols; (d) chlorohexidine and derivatives thereof; (e) C12-14alkybetaines and C8–C18fatty acid amidoaklylbetaines; (f) amphoteric surfactants; (g) trihalocarbanilides; (h) quaternary and polyquaternary compounds; and (i) thiazole compounds.Type: GrantFiled: September 6, 2001Date of Patent: September 12, 2006Assignee: Ciba Specialty Chemicals Corp.Inventors: Jianwen Mao, Albert Stehlin, Dietmar Ochs, Victor Paul Eliu
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Patent number: 7091193Abstract: Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone.Type: GrantFiled: October 9, 2003Date of Patent: August 15, 2006Assignee: Kosan biosciences IncorporatedInventors: Michael J. Sherrill, Robert G. Johnson, Jr.
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Patent number: 7091335Abstract: Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the resulting hydrogenated malto-oligosaccharide is derivatized, such as via oxidation, esterification, etherification, or enzymatic modification. The derivatization of such hydrogenated malto-oligosaccharides results in a surprisingly low level of a formation of by-products and products of degradation. In a particularly preferred embodiment of the invention, a mixture of malto-oligosaccharides is catalytically hydrogenated under reaction conditions suitable to substantially preserve the degree of polymerization (DP) profile of the mixture. The resulting malto-oligosaccharide mixture then is derivatized to form a derivatized malto-oligosaccharide mixture.Type: GrantFiled: December 9, 2003Date of Patent: August 15, 2006Assignee: Grain Processing CorporationInventors: Richard L. Antrim, Frank W. Barresi
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Patent number: 7091192Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.Type: GrantFiled: June 25, 1999Date of Patent: August 15, 2006Assignee: California Institute of TechnologyInventors: Mark E. Davis, Hector Gonzalez, Suzie Sue Jean Hwang
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Patent number: 7087709Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: February 8, 2005Date of Patent: August 8, 2006Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
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Patent number: 7084132Abstract: A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, ?-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.Type: GrantFiled: April 25, 2005Date of Patent: August 1, 2006Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Mark G. Hartell, Apurba K. Bhattacharjee, Rickey P. Hicks, John E. VanHamont, Wilbur K. Milhous
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Patent number: 7030237Abstract: In a reaction system having at least two liquid-liquid interfaces between an organic phase of raw material containing a compound(s) to be separated and an aqueous phase of an aqueous solution of inclusion-complexing agent and between that aqueous phase and an organic phase(s) of extraction solvent(s), the compound(s) to be separated is entrapped into the aqueous phase through formation of an inclusion complex(es) of the inclusion-complexing agent with the compound(s), while the compound(s) is entrapped into the organic phase(s) of extraction solvent(s) through dissociation of said inclusion complex(es). The foregoing operation is performed using, for example, a squarish U-shaped tube or an H-shaped tube with bottom plates. Preferred examples of inclusion-complexing agent include highly water-soluble branched cyclodextrins.Type: GrantFiled: December 21, 2000Date of Patent: April 18, 2006Assignees: National Institute of Advanced Industrial Science and Technology, Ensuiko Sugar Refining Co. Ltd., Bio Research Corporation of YokohamaInventors: Isamu Uemasu, Kozo Hara, Hideki Takahashi
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Patent number: 7026008Abstract: A stable hard-boiled candy prepared with sucrose, hydrogenated starch hydrolysate (HSH) and optionally 42 DE corn syrup. It is a preferred embodiment of the invention that the candy be produced without the use of a vacuum. The candy exhibits good stability characteristics in terms of reduced moisture absorption when exposed to humidity and temperature compared to candies prepared without HSH. Additionally, the candy has a high index of whiteness.Type: GrantFiled: September 13, 2002Date of Patent: April 11, 2006Assignee: SPI Polyols Inc.Inventor: Anh Si Le