Metal Containing Patents (Class 536/121)
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Publication number: 20100239493Abstract: The present invention includes polyol modified titanium compounds, their preparation and use in methods to make biomolecule compatible monolithic titania. The invention also includes the use of the biomolecule compatible monolithic titania in bioanalytic applications, for example in biosensors, chromatographic columns, microarrays and bioaffinity columns.Type: ApplicationFiled: September 24, 2007Publication date: September 23, 2010Applicant: MCMASTER UNIVERSITYInventors: Yunyu Yi, Michael A. Brook, John D. Brennan, Yang Chen
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Publication number: 20100190180Abstract: The subject invention concerns methods and materials for cancer screening using platinum complexes to detect a STAT protein biomarker. Platinum (IV) complexes interacting with STATs directly correlate with the STAT expression. In one embodiment, fluorescently-labeled and/or antibody-linked platinum (IV) complexes can be used to assess the STAT expression and define malignant potential. Other methods such as imaging (MRI, e.g.) can also be used to assess platinum-STAT interactions. The STAT protein can be, for example, STAT3.Type: ApplicationFiled: July 6, 2006Publication date: July 29, 2010Inventor: Heidi Kay
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Publication number: 20100152708Abstract: Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity.Type: ApplicationFiled: December 7, 2009Publication date: June 17, 2010Inventors: Jun Li, Trevor Squier, Zheng Zhang, Chad Huval, William Shannan O'Shaughnessy, Michael Hencke, Michael Bouchard, Christopher R. Loose
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Patent number: 7683038Abstract: The present invention relates to percarboxylated polysaccharide selected from the group consisting of gellan, carboxymethylcellulose, pectic acid, pectin and hyaluronic acid derivatives; the process for their preparation and their use in the pharmaceutical, biomedical, surgical and healthcare fields.Type: GrantFiled: February 28, 2003Date of Patent: March 23, 2010Assignee: Fidia Farmaceutici S.p.A.Inventors: Davide Bellini, Vittorio Crescenzi, Andrea Francescangeli
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Publication number: 20100062417Abstract: The invention provides a hybrid construct comprising at least a zeolite crystal and at least one biological moiety such as for example a cells bacteria or virus and a method for the production thereof.Type: ApplicationFiled: November 2, 2007Publication date: March 11, 2010Applicant: WESTFALISCHE WILHELMS-UNIVERSITAT MUNSTERInventors: Luisa De Cola, Zoran Popovic
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Publication number: 20100035830Abstract: The invention provides an iron-carbohydrate complex compound which is characterized by a content of iron(II). The invention also provides processes for the preparation of the iron-carbohydrate complex compound and the use thereof for treatment of iron deficiency anaemias.Type: ApplicationFiled: January 15, 2008Publication date: February 11, 2010Applicant: VIFOR (INTERNATIONAL) AGInventors: Stefan Reim, Peter Geisser
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Publication number: 20100021957Abstract: A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer; (2) adding into the solution a ligand; and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate.Type: ApplicationFiled: June 17, 2009Publication date: January 28, 2010Applicant: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Shu-Yi LIN, Leu-Wei Lo, Chung-Shi Yang
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Publication number: 20100016564Abstract: The present invention relates to a method of preparing an immobilised metal ion affinity chromatography (IMAC) adsorbent, which comprises to provide chromatography ligands comprised of alkylene diamine triacetic acid, or a derivative thereof, and coupling thereof to a carrier via nitrogen. In an advantageous embodiment, the alkylene diamine triacetic acid is ethylene diaminetriacetic acid (ED3A).Type: ApplicationFiled: May 28, 2007Publication date: January 21, 2010Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Lars C. Andersson, Makonnen Belew, Tesfai Gebru, Gunnar Glad, Helena Lindgren, Nils Norrman
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Publication number: 20090306362Abstract: The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention, is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.Type: ApplicationFiled: July 24, 2007Publication date: December 10, 2009Applicants: Nippon Sheet Glass Company, Limited, KYUSHU UNIVERSITYInventors: Koichiro Nakamura, Yoshio Hisaeda, Ling Pan
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Publication number: 20090299052Abstract: The present invention relates to a cost-effective process for manufacture of iron sucrose complex.Type: ApplicationFiled: December 2, 2005Publication date: December 3, 2009Applicant: EMCURE PHARMACEUTICALS LIMITEDInventors: Milind Moreshwar Gharpure, Baburao Manikrao Bhawal, Rajiv Pandurag Sutar, Satish Ramanlal Mehta
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Publication number: 20090240032Abstract: It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein interaction easily and at a low cost using the same without labeling, and a method for simply recovering a protein from a sugar-protein interactant. A maltose-immobilized gold nanoparticle was obtained by binding a ligand complex, in which maltose and a linker compound had been bound to each other, to a gold nanoparticle. By adding this maltose-immobilized gold nanoparticle to a dilution series of concanavalin A, a sugar-protein interactant of maltose and ConA was formed, and red-purple color derived from a colloidal solution of maltose-immobilized gold nanoparticle disappeared. That is, sugar-protein interaction could be confirmed by visual observation without labeling.Type: ApplicationFiled: May 26, 2006Publication date: September 24, 2009Applicants: Japan Science and Technology Agency, National University Corporation, Yasuo SudaInventors: Yasuo Suda, Tomoaki Nishimura, Yuko Kishimoto, Hiromi Nakagawa
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Publication number: 20090143329Abstract: The present invention provides a postprandial GIP secretion inhibitor comprising potassium alginate as an active ingredient. The postprandial GIP secretion inhibitor of the present invention is useful as a medicine or a food product. The present invention also provides use of potassium alginate for the manufacture of a postprandial GIP secretion inhibitor. The present invention also provides a method for inhibiting postprandial GIP secretion, which comprises administering potassium alginate to a subject in need thereof or causing a subject in need thereof to consume potassium alginate.Type: ApplicationFiled: November 28, 2008Publication date: June 4, 2009Applicant: KAO CORPORATIONInventors: Junko SUZUKI, Akira SHIMOTOYODOME, Tomohisa ICHIBA
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Publication number: 20090105470Abstract: A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose)-O—Snbutyl.sub.2-O-(6-O-sucrose) or as 1,3.(di O-sucrose) dibutyl stannylene. The adduct is acylated to yield sucrose-6-acetate or sucrose-6-benzoate as major product.Type: ApplicationFiled: February 6, 2006Publication date: April 23, 2009Inventors: Rakesh Ratnam, Mohammed Mofizuddin, Sundeep Aurora
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Publication number: 20090069500Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: ApplicationFiled: January 22, 2004Publication date: March 12, 2009Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis G. Stavrianopoulos, Elazar Rabbani
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Publication number: 20080249298Abstract: Heparinoid derivatives comprising a chelating agent which is covalently bonded to the heparinoid, and a paramagnetic metal cation from the series of transition metals Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Mo, Ru or of the lanthanides, are suitable for producing medicaments both for therapy and for diagnostic purposes, for localizing the dose employed, and for monitoring the result of treatment of disorders such as thrombosis and osteoarthrosis.Type: ApplicationFiled: June 19, 2008Publication date: October 9, 2008Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Wolfgang ULMER, Hans-Paul JURETSCHKE, Christopher KERN
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Publication number: 20080221314Abstract: Heteromolecular metal-humic organic complexes of the type: (A)n-(Metal)x-(B)m where A is one or several humic complexes which may be totally or partially sulfonated or may have been treated with an amine in order to protect the carboxylic groups from interacting with polyvalent cations, and B is a non-humic complexing (organic chelating agent) compound, the biological and chemical stability whereof allows for protection of the metal and the multitoothed molecule involved in the complex against degradation phenomena, both chemical and microbiological, having the beneficial effect of humic acid, as an effective plant growth and nutrition stimulant and as a metabolic and immune system activator in animals and humans.Type: ApplicationFiled: March 6, 2008Publication date: September 11, 2008Applicant: Timac Agro Espana, S.A.Inventors: Jose Maria Garcia-Mina Freire, Roberto Baigorri Ekisoain, Angel Maria Zamarreno Arregui, Eva Bacaicoa Llundain, Marta Fuentes Ramirez
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Publication number: 20080207558Abstract: Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by reaction between an alkaline or alkaline earth bromine and an alkaline hypochlorite, the complexation of the activated sugar in solution with a ferric salt dissolved in an aqueous solution, the purification of the resulting solution through ultrafiltration and finally the stabilization of the trivalent iron-sugar complex by heating at a temperature between 60° C. and 100° C. for a period between 1 and 4 hours at a pH between 9.0 and 11.0.Type: ApplicationFiled: March 14, 2006Publication date: August 28, 2008Applicant: BIOFER S.p.A.Inventors: Stefania Sacchi, Mauro Montorsi, Egidio Marchi
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Publication number: 20080132465Abstract: A method and apparatus for isolating iron components in serum is provided. The method includes passing a serum sample through a separation column having a solid phase and retaining with the solid phase an iron component, such as an iron carbohydrate, in the column. Elution of the solid phase may retrieve an eluate containing the iron component. The amount of iron component present in the eluate may then be measured. The present method and apparatus advantageously permit the direct measurement of the iron component present in the serum.Type: ApplicationFiled: December 5, 2006Publication date: June 5, 2008Inventors: Vincent Windisch, Pui-Ho Yuen, Jing Jun Huang, Jingzhen Xu
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Patent number: 7078519Abstract: Methods for forming structurally defined organosilicon carbohydrates are provided. Additionally, structurally defined organosilicon carbohydrates are provided. The structurally defined organosilicon carbohydrates may be formed by contacting a hydrolase enzyme with an organosilicon reactant and a carbohydrate reactant. The enzyme may catalyze the formation of an ester bond between carboxylic acid, ester, or amide functional groups of the organosilicon or carbohydrate reactant and alcohol functional groups of the carbohydrate or organosilicon reactant. The enzyme may catalyze the formation of an amide bond between carboxylic acid, ester, or amide functional groups of the organosilicon or carbohydrate reactant and amine functional groups of the carbohydrate or organosilicon reactant.Type: GrantFiled: August 15, 2003Date of Patent: July 18, 2006Assignees: Dow Corning Corporation, Polytechnic UniversityInventors: Kurt Friedrich Brandstadt, Thomas Howard Lane, Richard A. Gross
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Patent number: 6872821Abstract: Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.Type: GrantFiled: April 23, 2003Date of Patent: March 29, 2005Assignee: National Starch & Chemical Investment Holding CorporationInventors: A. Levent Cimecioglu, John S. Thomaides
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Patent number: 6872820Abstract: Finely divided polysacharide derivatives are described. The finely divided polysacharide derivatives are prepared by a process comprising: a) forming an aqueous composition comprising a polysaccharide derivative and water, in which the polysaccharide derivative is soaked or dissolved; b) converting the polysaccharide derivative of the aqueous composition into finely divided solid particles by, (i) contacting the aqueous composition with superheated water vapor in a dryer-pulverizer; or (ii) causing the polysaccharide derivative of the aqueous composition to flocculate; and c) optionally drying the finely divided solid particles of step b). The primary structures of the polysaccharide starting material are largely removed, and the product has a shape factor of less than 5 and greater than or equal to 1.Type: GrantFiled: October 1, 2001Date of Patent: March 29, 2005Assignee: Wolff Walsrode AGInventors: Gunter Weber, Detmar Redeker, Bernd Klinksiek, Jürgen Hinderer, Benno Ulfik
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Patent number: 6812223Abstract: The present invention relates to novel crystalline glucosamine sulphate metal salts for use in the treatment of acute and chronic forms of rheumatic and arthritic diseases and of all the pathological conditions originating from metabolic disorders of the osteo-articular tissues. More particularly, the present invention relates to novel crystalline glucosamine sulphate metal salts having low metal content wherein the metal may be either sodium or potassium. The present invention further relates to a solution-based and a solvent-free process for the preparation of the novel crystalline glucosamine sulphate metal salts having low metal content and to pharmaceutical compositions comprising the novel crystalline glucosamine sulphate metal salts having low metal content.Type: GrantFiled: June 2, 2003Date of Patent: November 2, 2004Assignee: Nicholas Piramal India LimitedInventors: Triptikumar Mukhopadhyay, Ravi Gajanan Bhat, E. S. Sreekumar
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Patent number: 6803456Abstract: A method of making an arginine silicate-containing complex and its use in the prevention and treatment of atherosclerosis and as a dietary supplement are claimed. The arginine silicate complex is synthesized by combining arginine, potassium silicate and inositol.Type: GrantFiled: August 13, 2003Date of Patent: October 12, 2004Assignee: Rutherford Chemicals LLCInventor: Erven James Kuhlmann
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Patent number: 6703498Abstract: Water-soluble metal ion affinity compounds and methods for using the same are provided. The subject compounds include an aspartate based metal chelating ligand bonded to a water-soluble polymeric substrate, where the ligand is complexed with a metal ion. In certain embodiments, the subject compounds further include a member of a signal producing system, e.g., a directly or an indirectly detectable label moiety. Also provided are water-insoluble supports having the subject compounds present on, e.g., immobilized on, at least one surface thereof. The subject compounds find use in a variety of different applications, including analyte detection and analyte purification applications.Type: GrantFiled: June 20, 2002Date of Patent: March 9, 2004Assignee: Clontech Laboratories, Inc.Inventor: Grigoriy S. Tchaga
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Patent number: 6608043Abstract: The present invention provides an agent for treatment of arthritic diseases such as rheumatoid arthritis that has for its active ingredient a complex of hyaluronic acid and zinc. This complex synergistically inhibits proliferation of synovial cells and suppresses matrix metalloproteinase MMP-9, which is produced by synovial cells, as compared with its constituents, hyaluronic acid and zinc, alone.Type: GrantFiled: September 7, 2001Date of Patent: August 19, 2003Assignees: Takata Seiyaku Co., Ltd., Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Isao Serizawa, Keisei Maekawa, Janos Illes, Erzsebet Neszmeli
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Patent number: 6586588Abstract: Polysaccharide aldehydes are prepared using selective oxidation involving the use of nitroxyl radical mediated aqueous oxidation with a limited amount of oxidant and defined reaction conditions. These polysaccharide aldehyde derivatives having maximum effective aldehyde and minimal carboxylic acid levels making them especially useful as wet, temporary wet and dry strength additives for paper.Type: GrantFiled: August 10, 2000Date of Patent: July 1, 2003Assignee: National Starch and Chemical Investment Holding CorporationInventors: A. Levent Cimecioglu, John S. Thomaides
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Patent number: 6570009Abstract: The invention relates to a highly regioselective method for preparing a derivative of cyclodextrin, &bgr;-cyclodextrin in particular, monosulfonylated at C-6, in which said cyclodextrin is caused to react with a sulfonylation agent, in an alkaline aqueous solution, in the presence of a metal salt able to form a co-ordination complex with the secondary hydroxyl groups of the cyclodextrin, and after the reaction said cyclodextrin derivative monosulfonylated at C-6 is recovered from the reaction mixture. The monosulfonylated derivatives of cyclodextrins find particular application as starting material for access to monofunctionalized derivatives of cyclodextrins.Type: GrantFiled: December 20, 2000Date of Patent: May 27, 2003Assignee: Centre National de la Recherche ScientifiqueInventors: Jacques Defaye, Serge Crouzy, Nicolas Evrard, Ho Law
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Publication number: 20030066523Abstract: A sugar/additive blend useful as a binder or impregnant for carbon products. Simple sugars as well as sucrose are combined either in solution or in solid form with reactive additives such as ammonium hydrogen phosphate, ammonium chloride and para-toluene sulfuric acid. The sugar/additive blends form more and denser carbon residue than sugar alone when subjected to pyrolysis.Type: ApplicationFiled: June 28, 2002Publication date: April 10, 2003Applicant: UCAR Carbon Company Inc.Inventors: Irwin Charles Lewis, Terrence Anthony Pirro
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Patent number: 6528497Abstract: Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.Type: GrantFiled: September 5, 2000Date of Patent: March 4, 2003Assignees: Sanofi-Synthelabo, Akzo Nobel N.V.Inventors: Johannes Basten, Cornelia Dreef-Tromp, Pierre Alexandre Driguez, Philippe Duchaussoy, Jean Marc Herbert, Maurice Petitou, Constant Van Boeckel
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Publication number: 20020086991Abstract: Aluminoxanes are used as activators for the gas, solution or slurry phase polymerization of olefins in the presence of single site catalysts. Aluminoxanes contain residual aluminum alkyls which may poison the catalysts. The residual aluminum alkyls may be bound an/or removed from the aluminoxanes by treatment with carbohydrates such as cellulose, starch or sugar.Type: ApplicationFiled: December 4, 2001Publication date: July 4, 2002Applicant: NOVA CHEMICALS (INTERNATIONAL) S. A.Inventors: Peter Phung Minh Hoang, Dusan Jeremic, Jason Roy Kearns, Iain McLaren Coulter, Robert D. Donaldson
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Patent number: 6403777Abstract: Transition metal complexes, referred to hereinafter as “metalloligands”, that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: wherein R1 is an amino group, i.e. an NH, or an alkylamino group comprising 1 or 2 carbon atoms; wherein R2 is selected from the group consisting of an amino group, a hydroxyl group, i.e., O(H), an alkylamino group comprising 1 or 2 carbon atoms; and an alkylhydroxyl group comprising 1 or 2 carbon atoms; wherein J is a ligand which comprises at least one carbon-containing five-membered or six-membered ring structure; and wherein M is a transition metal ion which is bound via coordinate bonds to R1 and R2.Type: GrantFiled: July 6, 1999Date of Patent: June 11, 2002Assignee: The Ohio State University Research FoundationInventor: James A. Cowan
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Patent number: 6342467Abstract: A chemical system and method to stop or minimize fluid loss during completion of wells penetrating hydrocarbon formations are provided. The inventions relates to formulating a highly stable crosslinked hydroxyethyl cellulose (HEC), control released viscosity reduction additives, and user friendly packaging. The chemical system contains a linear HEC polymer solution, a low solubility compound which slowly raises the fluid pH, a chelating agent which further increases the pH level beyond the equilibrium achievable by the low solubility compound, a metal crosslinker which crosslinks HEC at elevated pH, a crosslink delaying agent which allows fluid viscosity to remain low until the fluid reaches the subterranean formation, and optionally an internal breaker. The chemical additives are packaged as an integrated pallet and transported to a field location which allows operators to conveniently mix them before pumping.Type: GrantFiled: November 2, 2000Date of Patent: January 29, 2002Assignee: Schlumberger Technology CorporationInventors: Frank F. Chang, Mehmet Parlar
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Patent number: 6280628Abstract: Heavy metals including lead, copper, zinc, and cadmium, are effectively extracted from sludge mixtures by treatment of the mixture with carboxyl derivatives of fructans, having a degree of substitution of 0.2-3.0.Type: GrantFiled: April 20, 2000Date of Patent: August 28, 2001Assignee: Cooperatie Cosun U.A.Inventors: Mariëtte Ellen Boukje Bolkenbaas, Hendrika Cornelia Kuzee, Henricus Wilhelmus Carolina Raaijmakers
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Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
Patent number: 6231982Abstract: The invention is directed to the preparation of magnetic and non-magnetic particles coated with a polyaldehyde dextran material and a process for making the same. The polyaldehyde dextran coated particles of the invention are suitable for use in immunological assays and exhibit a reduced matrix effect in such assays when compared to convention particles without a polyaldehyde dextran coating.Type: GrantFiled: December 10, 1997Date of Patent: May 15, 2001Assignee: Dade Behring Inc.Inventor: Chengrong Wang -
Patent number: 6211356Abstract: The invention concerns metallocene-phosphoramidite conjugates comprising one or a plurality of metallocenes and one or a plurality of phosphoramidites. The invention further concerns a process for preparing the metallocene-phosphoramidite conjugates and their use.Type: GrantFiled: October 21, 1998Date of Patent: April 3, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Manfred Wiessler, Dagmar Schütte
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Patent number: 6165378Abstract: The present invention provides a polysaccharide-magnetic metal oxide complex consisting of a polysaccharide derivative obtained by carboxyalkyl-etherifying and unsubstituted or substituted aminoalkyl-etherifying a polysaccharide (the above carboxy group and/or amino group may be of a salt form) and a magnetic metal oxide. The above complex has a slow blood clearance and a low toxicity and is useful as a nuclear magnetic resonance imaging contrast medium.Type: GrantFiled: March 1, 1999Date of Patent: December 26, 2000Assignee: Meito Sangyo Kabushiki KaishaInventors: Shigeo Maruno, Masakatsu Hasegawa, Takamasa Hanaichi, Katsutoshi Murase, Hisato Yamada, Hideo Nagae, Kyoji Kito
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Patent number: 6156735Abstract: The present invention is directed to an arginine-silicate complex and its use in the prevention and treatment of atherosclerosis, as a dietary supplement and for promotion of structural integrity of bones and cartilage.Type: GrantFiled: December 13, 1999Date of Patent: December 5, 2000Assignee: Nutrition 21Inventors: Mark F. McCarty, Jan Zielinski
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Patent number: 6139751Abstract: Heavy metals can be effectively complexed with a derivative of a fructan, which derivative contains complexing groups chosen from --X--CY--ZM, --X--CY--ZM, --X--CY--S--S--CY--X--Q, --PY'(--Z'M).sub.2, --SO.sub.3 M and --NR--CH.sub.2 --COOM, where M is a metal or hydrogen, Q denotes the residue of an alcohol or polyol, R is hydrogen or carboxymethyl and X, Y, Y', Z and Z', independently of one another, are O, S or NH and at least one of X, Y and Z is S, with a degree of substitution of 0.1-2.5. The complexing groups are in particular xanthate, xanthide or dithiocarbamate groups.Type: GrantFiled: January 14, 1999Date of Patent: October 31, 2000Assignee: Cooperatie Cosun U.A.Inventors: Piet Marc Paul Bogaert, Theodoor Maximiliaan Slaghek, Henricus Wilhelmus Carolina Raaijmakers
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Patent number: 6113880Abstract: The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.Type: GrantFiled: December 17, 1998Date of Patent: September 5, 2000Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich
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Patent number: 6068831Abstract: The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane complexes have general formula (I), in which n represents the numbers 6, 7 or 8; m represents the numbers 2 to 50; X represents a direct bond or the radical --O--CO--CH(CH.sub.3)--; R.sub.1 and Y have the meaning that is indicated in the description and represent R.sub.3 --Y--R.sub.4 polyalkylene glycols.Type: GrantFiled: December 30, 1998Date of Patent: May 30, 2000Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich
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Patent number: 5977087Abstract: Aphthous ulcers and other lesions of the mucosal, submucosal, epidermal, dermal or subcutaneous tissue of the mouth are treated by a method comprising administering to a patient suffering from such lesion a topical preparation containing sucralfate as an essential ingredient. The invention is also drawn to a preparation comprising sucralfate as an essential ingredient, and a method for preparing the same. The sucralfate is combined with an appropriate pharmaceutical medium to form a homogenous mixture which can then be dispersed in other media to form a preparation useful for topical application to the lesion.Type: GrantFiled: August 30, 1991Date of Patent: November 2, 1999Assignee: Pehrom Pharmaceutical CorporationInventors: David W. Pehrson, Sr., Michael P. Romanowsky
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Patent number: 5955601Abstract: Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other structurally related chelate compounds.Type: GrantFiled: March 5, 1997Date of Patent: September 21, 1999Assignee: E G & G WallacInventors: David Gordon Sherman, Charlene Elinor Bush, Laura Ann Beninsig, Kurt Mathew VandenBrink
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Patent number: 5952308Abstract: A mineral absorption promoting agent containing oligouronic acid, e. g. oligogalacturonic acid or oligomannuronic acid ?degree of polymerization (n)=1 to 9! is described. Since this oligouronic acid ?polymerization degree (n)=1 to 9! forms a complex with mineral, it promotes absorption of minerals into living organisms by simply adding it to foods, drinks or pharmacentical compositions for oral use. Since the agent has no problem with safety, the agent is suitable for repeated eating, drinking or taking, and the agent is very effective.Type: GrantFiled: July 24, 1992Date of Patent: September 14, 1999Assignee: Pola Chemical Industries Inc.Inventors: Noboru Nakanishi, Yoshio Kitada
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Patent number: 5939394Abstract: The present invention relates to compositions and methods for the prevention and/or treatment of allergic, autoimmune, septic shock or infectious diseases using magnesium gluconate alone or in combination with one or more antioxidants or an antiinflammatory agent. The invention also relates to the inhibition of production of inappropriate levels of lipid mediators and cytokines.Type: GrantFiled: April 23, 1997Date of Patent: August 17, 1999Assignee: Fleming & CompanyInventors: Thomas E. Fleming, Herbert C. Mansmann, Jr.
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Patent number: 5849720Abstract: A method for producing soluble preparations of neutral glucan polymers is disclosed. The method involves treating whole glucan particles with a unique sequence of acid and alkaline treatments to produce soluble glucan. The soluble glucan can be purified to obtain a physiologically acceptable solution of neutral glucan molecules. A soluble neutral glucan preparation is obtained which forms a clear solution at a neutral pH and is equilibrated in a pharmaceutically acceptable carrier.Type: GrantFiled: March 8, 1995Date of Patent: December 15, 1998Assignee: Alpha-Beta Technology, Inc.Inventors: Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff
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Patent number: 5831080Abstract: The present invention relates to organosilicon compounds containing glycoside radicals, having units of the formula ##STR1## in which R is identical or different and represents a hydrogen atom or an organic radical,a is 0, 1, 2 or 3,b is 0, 1, 2 or 3 andR.sup.1 can be identical or different and represents a radical of the formulaZ--(R.sup.2 O).sub.c --R.sup.3 -- (II)in whichZ represents a glycoside radical which is built up from 1 to 10 monosaccharide units,R.sup.2 can be identical or different and represents an alkylene radical,c is 0 or a number from 1 to 20, andR.sup.3 represents an alkylene radical, with the proviso that the sum of a and b is less than or equal to 3 and the organosilicon compound comprising units of the formula (I) contains at least one radical R.sup.1 per molecule.Type: GrantFiled: April 22, 1996Date of Patent: November 3, 1998Assignee: Wacker-Chemie GmbHInventors: Johann Sejpka, Franz Wimmer
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Patent number: 5831078Abstract: A method is disclosed for producing a pentitol. The disclosed method more particularly relates to producing arabinitol from hexoses, e.g. galactose and/or glucose, and/or fructose, or lactose hydrolysate, or invert sugar, or starch hydrolysates. The hexose is oxidatively decarboxylated to a C.sub.5 -aldonic acid which is thereafter catalytically hydrogenated to obtain the desired arabinitol.Type: GrantFiled: July 23, 1997Date of Patent: November 3, 1998Assignee: Cerestar Holding B.V.Inventors: Myriam Elseviers, Hilde Odile Jozefine Lemmens, Sonia Marianne Jeannine Coomans, Harald Wilhelm Walter Roper
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Patent number: 5707970Abstract: An arginine silicate-containing complex and its use in the prevention and treatment of atherosclerosis and as a dietary supplement. The arginine silicate complex is synthesized by combining arginine, potassium silicate and inositol. The complex is administered orally three times per day in an amount ranging from about 250 mg to about 2,500 mg as a preventative or therapeutic agent.Type: GrantFiled: February 12, 1997Date of Patent: January 13, 1998Assignee: Nutrition 21Inventors: Mark F. McCarty, Jan Zielinski
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Patent number: 5693623Abstract: Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.Type: GrantFiled: June 6, 1995Date of Patent: December 2, 1997Assignee: LifeGroup S.p.A.Inventors: Francesco della Valle, Roberto Cerini, Gabriella Calderini
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Patent number: 5686602Abstract: A cellulose polymer network crosslinked with metal ions selected from the group consisting of: Al.sup.+3, Zr.sup.+4, and Ti.sup.+4, the crosslinked cellulose polymer network having incorporated therein a colloidal sol containing metal oxide-hydroxide particles wherein the metal is Al, Zr, or Ti. The inventive material is optically clear and can be used to cast microporous films, either supported or unsupported, which are useful as coatings on ink jet recording materials.Type: GrantFiled: October 26, 1995Date of Patent: November 11, 1997Assignee: Minnesota Mining & Manufacturing CompanyInventors: Omar Farooq, David W. Tweeten, Mohammad Iqbal, Subodh K. Kulkarni