Metal Containing Patents (Class 536/121)
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Patent number: 4551524Abstract: The invention relates to compounds that are complexes of diaminocyclohexane platinum glucuronic acid halide and the use of these compounds as anti-tumor agents for lower animals.Type: GrantFiled: June 23, 1983Date of Patent: November 5, 1985Assignee: Yoshinori KidaniInventors: Yoshinori Kidani, Masahide Noji
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Patent number: 4524202Abstract: The invention relates to a process for the synthesis of 1,1'-diacetals, which method is also suitable for the stereoselective synthesis of glycosides with the 1,1'-diacetal structure. The process involves reacting a silyl compound of formula (II) with an acetal of formula (III) in the presence of a catalyst of formula (IV) or (V) in a suitable solvent.Type: GrantFiled: June 24, 1982Date of Patent: June 18, 1985Assignee: Bayer AktiengesellschaftInventors: Lutz-Friedjan Tietze, Roland Fischer
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Patent number: 4495186Abstract: The invention relates to complex salts of N-cyclohexyl-piperazino-acetamides or propionamides with dihydroxy aluminum-.alpha.-hydroxy-carboxylates, a process for preparing them and the use thereof as antiulcer-antisecretive-buffering drugs.Type: GrantFiled: January 31, 1983Date of Patent: January 22, 1985Assignee: Camillo Corvi S.p.A.Inventor: Camillo C. Mora
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Patent number: 4490525Abstract: Metal-containing or metal-free phthalocyanine-polysaccharide complex defined below is used for removal of mutagens and carcinogens present in aqueous solutions, the said complex having formula of ##STR1## wherein Pc is a metal-containing or metal-free phthalocyanine residue, A is an alkylene group having 2 to 6 carbon atoms or an arylene group having 1 to 3 rings, the integers m and n satisfy both 2<m+n.ltoreq.4 and 1.ltoreq.n.ltoreq.2, and Z is an activated polysaccharide residue.Type: GrantFiled: July 1, 1982Date of Patent: December 25, 1984Assignee: Sumitomo Chemical Company, LimitedInventors: Hikoya Hayatsu, Yasuo Tezuka
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Patent number: 4487766Abstract: Biochemically active materials having anabolic bioactivity for favorably influencing the intracellular and systemic metabolism of higher organisms are disclosed. The materials consist of water-soluble acid carbonization products of lignoid natural materials in the form of decationized alkali salts and have their catabolic activity at least in part inhibited by reaction with trace metal ions. The active material carbonization products are produced by treating lignoid natural material with an aqueous alkali hydroxide solution. The resulting solution is adjusted to a weakly acid pH and treated with a trace metal salt solution. The reaction mixture thus obtained was dried, optionally after addition of a suitable carrier product. Also described are growth-promoting agents, particularly suited for animal feed supplements, as well as therapeutic agents which contain this active material useful in treating metabolism disturbances of higher organisms or for use with disturbances of the metabolism.Type: GrantFiled: February 23, 1983Date of Patent: December 11, 1984Assignee: Lohmann Tierernahrung GmbHInventor: Walter J. Mach
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Patent number: 4476114Abstract: A composition is provided for the treatment of deficiency state of iron and selenium in a mammal, which composition comprises a precipitate-free solution containing a deficiency-treating amount of an iron compound and a selenium compound, wherein the iron compound is ferric dextran, ferric polymaltose or the corresponding hydrolysates thereof, and the selenium compound is selenium dioxide or selenium selenite.Type: GrantFiled: April 5, 1983Date of Patent: October 9, 1984Assignee: Orion-yhtyma OyInventor: Timo J. Pekkanen
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Patent number: 4470976Abstract: Poly-cation salts of 4-O-polyhexaose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.Type: GrantFiled: August 29, 1983Date of Patent: September 11, 1984Assignee: American Cyanamid CompanyInventors: Thomas G. Miner, Robert E. Schaub, Seymour Bernstein
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Patent number: 4447337Abstract: Aqueous compositions thickened by galactomannan gums are described which are stabilized by a stabilizer system comprising soluble molybdenum and a thiourea.Type: GrantFiled: February 24, 1982Date of Patent: May 8, 1984Assignee: Monsanto CompanyInventors: Mohammad S. Adl, Gary H. Kegeler, Howard L. Vandersall
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Patent number: 4447336Abstract: Aqueous compositions thickened by galactomannan gums are described which are stabilized by soluble molybdenum.Type: GrantFiled: December 18, 1981Date of Patent: May 8, 1984Assignee: Monsanto CompanyInventor: Howard L. Vandersall
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Patent number: 4430490Abstract: Polyether polyols and their method of preparation are disclosed. The polyether polyols are prepared by reacting polyhydric alcohols with an alkylene oxide in the presence of an alkaline catalyst. The reaction mixture is then treated with a hydroxy-carboxylic acid so as to neutralize the alkaline catalyst and form a clear reaction mixture without otherwise removing the alkaline catalyst. The polyether polyols are useful for the production of polyurethane foams.Type: GrantFiled: August 10, 1982Date of Patent: February 7, 1984Assignee: PPG Industries, Inc.Inventor: Herman P. Doerge
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Patent number: 4384113Abstract: Improved basic polysaccharides are prepared by contacting a polysaccharide with a tetravalent onium salt such as tetramethylammonium chloride prior to contacting it with a strong base such as sodium hydroxide. Polysaccharide derivatives having a greater degree and uniformity of substitution are prepared from such improved basic polysaccharides.Type: GrantFiled: March 23, 1982Date of Patent: May 17, 1983Assignee: The Dow Chemical CompanyInventor: William H. Daly
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Patent number: 4350811Abstract: Chiral Schiff bases according to the general formula: ##STR1## and chiral transition metal complexes thereof, wherein at least the carbon atom of the monosaccharide to which the iminyl nitrogen atom is attached is asymmetric, and at least one of the carbon atoms adjacent the aforesaid carbon atom bears a hydroxyl group, R.sup.1 and R.sup.6 which may be the same or different, are hydrogen or lower alkyl, R.sup.2 is hydrogen, or lower alkyl or together with R.sup.10 forms a divalent hydrocarbon group, R.sup.3 is hydrogen, a sugar residue, or --CH.sub.2 OR.sup.10 in which R.sup.10 is hydrogen, lower alkyl or together with R.sup.2 forms a divalent hydrocarbon group, R.sup.4 is hydrogen or --CH.sub.2 OR.sup.10 in which R.sup.10 is hydrogen, or a lower alkyl, R.sup.5 is hydrogen, OR.sup.1 or a sugar residue, provided that both R.sup.4 and R.sup.5 are not hydrogen, R.sup.7 and R.sup.8 which may be the same or different, are hydrogen, or lower alkyl, or where p is 1, may with the cyclic ring to which CR.sup.7 R.sup.Type: GrantFiled: July 8, 1980Date of Patent: September 21, 1982Assignee: Imperial Chemical Industries LimitedInventors: David Holland, David J. Milner
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Patent number: 4346216Abstract: Osmium carbohydrate complexes prepared by reacting osmium compounds and carbohydrates and their utilization as pharmaceutical compositions for the treatment of heavy metal poisoning and arthritis in mammals. The osmium carbohydrate complexes may also be utilized in X-ray diagnostic procedures as contrast enhancing agents.Type: GrantFiled: June 2, 1980Date of Patent: August 24, 1982Assignee: Research CorporationInventor: Conrad C. Hinckley
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Patent number: 4344894Abstract: 3-(Halogenovinyl- or propenyl-)-2,2-dimethyl cyclopropane-1-carboxylic acid esters, which are precursors of, or may themselves be, pyrethroid insecticides, are prepared by the reaction of certain halogenopentadienes with an alkyl diazoacetate in the presence of a catalyst which is a transition metal complex of certain chiral Schiff bases, which catalysts tend to increase the yield of preferred cis IR isomer relative to the other possible isomers.Type: GrantFiled: June 2, 1980Date of Patent: August 17, 1982Assignee: Imperial Chemical Industries LimitedInventors: Dale A. Laidler, David J. Milner
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Patent number: 4337335Abstract: Described are transition metal salt complexes of available neighboring amino and hydroxyl group pairs in polyamino organic compounds, their preparation, and use as intermediates in the preparation of selectively N-blocked polyamino organic compounds.Type: GrantFiled: December 26, 1979Date of Patent: June 29, 1982Assignee: Schering CorporationInventors: Tattanahalli L. Nagabhushan, William N. Turner, Alan Cooper
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Patent number: 4311832Abstract: Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the "emulsans") which, on a weight-for-weight basis, are probably the most efficient emulsifiers discovered and which possess certain characteristics that permit these unique extracellular microbial lipopolysaccharides to be widely used in cleaning oil-contaminated vessels, oil spill management, and enhanced oil recovery by chemical flooding. These classes have been named .alpha.-emulsans and .beta.-emulsans, both of which have substantially the same polymer backbone but differ from each other in certain important structural aspects.Type: GrantFiled: May 14, 1980Date of Patent: January 19, 1982Assignee: Petroleum Fermentations N.V.Inventors: David L. Gutnick, Eugene Rosenberg, Igal Belsky, Zosim Zinaida
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Patent number: 4311830Abstract: Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the "emulsans") which, on a weight-for-weight basis, are probably the most efficient emulsifiers discovered and which possess certain characteristics that permit these unique extracellular microbial lipopolysaccharides to be widely used in cleaning oil-contaminated vessels, oil spill management, and enhanced oil recovery by chemical flooding. These classes have been named .alpha.-emulsans and .beta.-emulsans, both of which have substantially the same polymer backbone but differ from each other in certain important structural aspects.Type: GrantFiled: May 14, 1980Date of Patent: January 19, 1982Assignee: Petroleum Fermentations N.V.Inventors: David L. Gutnick, Eugene Rosenberg, Igal Belsky, Zinaida Zosim
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Patent number: 4311829Abstract: Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the "emulsans") which, on a weight-for-weight basis, are probably the most efficient emulsifiers discovered and which possess certain characteristics that permit these unique extracellular microbial lipopolysaccharides to be widely used in cleaning oil contaminated vessels, oil spill management, and enhanced oil recovery by chemical flooding. These classes have been named .alpha.-emulsans and .beta.-emulsans, both of which have substantially the same polymer backbone but differ from each other in certain important structural aspects.Type: GrantFiled: May 14, 1980Date of Patent: January 19, 1982Assignee: Petroleum Fermentations N.V.Inventors: David L. Gutnick, Eugene Rosenberg, Igal Belsky, Zosim Zinaida
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Patent number: 4309535Abstract: Easily dispersible anionic water-soluble polymers are disclosed which are prepared by lightly treating particulate water-soluble polymer with a water-soluble aluminum salt and an aluminum chelant. Rate of hydration is retarded when the particles are added to aqueous media, allowing the particles to be dispersed completely before their surfaces hydrate sufficiently to gel and prevent complete dissolution.Type: GrantFiled: September 5, 1980Date of Patent: January 5, 1982Assignee: Hercules IncorporatedInventor: Thomas G. Majewicz
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Patent number: 4259324Abstract: Compounds of the formulae Y--R wherein Y is 1-thio-.beta.-L-fucose, 1-thio-.beta.-D-galactose or 1-thio-.beta.-lactose and R is 2-(1-adamantyl)ethyl, 3-[(p-tetrafluorophenethyl)phenyl]propyl, 6-(5-cholesten-3.beta.-yloxy)hex-3-ynl, oleyl, or hexadecyl are useful immunologic adjuvants in vaccines.Type: GrantFiled: July 31, 1979Date of Patent: March 31, 1981Assignee: Merck & Co., Inc.Inventors: Mitree M. Ponpipom, Tsung-Ying Shen, Robert L. Bugianesi
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Patent number: 4257903Abstract: A drilling fluid having extremely desirable physical properties which comprises an aqueous solution of a hydroxyalkyl polysaccharide derivative and a water soluble ionic aluminum crosslinking agent, preferably sodium aluminate.Type: GrantFiled: October 19, 1978Date of Patent: March 24, 1981Assignee: The Dow Chemical CompanyInventors: Clare H. Kucera, Donald N. DeMott
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Patent number: 4246399Abstract: Complexes of the formula:A.X.sub.nwherein A represents doxorubicin; wherein X represents Ca.sup.++, Mg.sup.++, Zn.sup.++, or Ni.sup.++ ; and wherein n represents one or two having enhanced stability are disclosed.The above-described compounds are inorganic complexes of a well-known and regulatory approved compound, doxorubicin, useful in the treatment of a variety of carcinomas. These complexes offer enhanced stability over doxorubicin per se.Type: GrantFiled: March 21, 1977Date of Patent: January 20, 1981Assignee: INTERx Research CorporationInventors: Takeru Higuchi, Pramod M. Kotwal
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Patent number: 4225592Abstract: Novel complexes of oligo- and polygalacturonic acids formed with essential metal ions and having the general formula (I), ##STR1## wherein n is an integer from about 10 to about 145M represents at least two metal cations selected from the group consisting of iron(II), copper(I), copper(II), magnesium(II), potassium(I), cobalt(II), manganese(II), zinc(II), chromium(III), molybdenum(V), vanadium(IV) and nickel(II) with the proviso that one of the ions must represent potassium(I) or magnesium(II), andz is an integer corresponding to the charge or the valence number of the metal atomare useful in foodstuffs and pharmaceutical preparations for administering essential elements to humans.Type: GrantFiled: February 12, 1979Date of Patent: September 30, 1980Inventors: Bela Lakatos, Julia Meisel nee Agoston, Mihaly Varju
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Patent number: 4201775Abstract: A new series of gold containing sugars having anti-arthritic activity are characterized by the presence of a bis[(triethylphosphine)aurio]sulfonium salt moiety at the 1-position of the glucopyranoside. The compounds are prepared by reacting a 1-S-triethylphosphinegold-1-thio-glucopyranoside with a triethylphosphinegold halide.Type: GrantFiled: March 23, 1979Date of Patent: May 6, 1980Assignee: SmithKline CorporationInventors: John J. Filan, Walter W. Holl, George R. Wellman
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Patent number: 4200738Abstract: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with a S-(triethylphosphineaurous)thiouronium salt.Type: GrantFiled: April 21, 1977Date of Patent: April 29, 1980Assignee: SmithKline CorporationInventors: David T. Hill, Blaine M. Sutton, Ivan Lantos
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Patent number: 4176228Abstract: A flavoring or sweetening agent comprising potassium-magnesium-calcium glycyrrhizin of the formula K.sub.x Mg.sub.y Ca.sub.z G wherein G is glycyrrhizic acid and the sum of x,2y and 2z is 2 and a process for recovering this product from licorice root are disclosed.Type: GrantFiled: September 14, 1978Date of Patent: November 27, 1979Assignee: MacAndrews and Forbes CompanyInventor: Harold A. Hartung
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Patent number: 4172195Abstract: A process for the separation and/or purification of oligo- and polyhydroxy compounds by introducing and subsequently eliminating protective groups, wherein oligo- and polyhydroxy compounds are reacted with bis(ethyl-pivaloyloxy)-diboroxane or ethylboroxine, optionally in inert solvents, the resulting O-ethylboranodiyl derivatives of the hydroxy compounds are separated off and the O-ethylboranodiyl protective groups are eliminated by alcoholic compounds, for example methanol or glycol.Type: GrantFiled: March 23, 1977Date of Patent: October 23, 1979Assignee: Studiengesellschaft Kohle mbHInventors: Roland Koster, Wilhelm V. Dahlhoff
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Patent number: 4153788Abstract: A process is provided for preparing mono-O-.beta.-hydroxyethyl-7-rutoside of the formula: ##STR1## which comprises contacting rutoside of the formula: ##STR2## in a solvent which is an at least partially aqueous medium with a boric acid alkali salt in an amount substantially not exceeding the amount necessary to form a boron complex of formula: reacting said boron complex with ethylene oxide to form a hydroxyethoxy compound of the formula ##STR3## and treating said hydroxyethoxy compound in an at least partially aqueous acid medium, whereby there is produced said mono-O-.beta.-hydroxyethyl-7-rutoside.Type: GrantFiled: March 7, 1977Date of Patent: May 8, 1979Assignee: ZYMA S.A.Inventors: Pierre Courbat, Alban Albert
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Patent number: 4138480Abstract: Metallic derivatives of anthracycline glycosides such as doxorubicin and daunorubicin are prepared by admixing divalent or trivalent metal cations, preferably Fe(III), with the glycoside and adjusting pH to promote chelation of the metal by bidentate ligands of the glycoside. The derivatives are isolated in essentially monomeric form, and preferably lyophilized for later reconstitution immediately before use in the treatment of transplanted tumors in mice. As compared with the parent glycosides, the derivatives exhibit greatly diminished cardiotoxicity and less general, hematological and digestive toxicity as well. At the same time, the antineoplastic efficacy of the derivatives in transplanted mouse tumor test systems appears to be approximately equivalent to that of the parent glycoside on a mg. to mg. basis. As a result, the therapeutic index of the derivative is greatly elevated over that of the parent, since the derivative may be safely administered in greater quantities.Type: GrantFiled: January 11, 1977Date of Patent: February 6, 1979Inventor: Mario G. Gosalvez
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Patent number: 4133952Abstract: The S-gold salt of 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose reacts with triethylphosphine in an organic solvent to produce auranofin.Type: GrantFiled: June 10, 1977Date of Patent: January 9, 1979Assignee: SmithKline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4131732Abstract: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with triethylphosphinegold(I) chloride and sodium or potassiumsulfide. Auranofin is an antiarthritic pharmaceutical compound. Auranofin is an orally active therapeutic agent which is useful in man as an antiarthritic.Type: GrantFiled: April 21, 1977Date of Patent: December 26, 1978Assignee: SmithKline CorporationInventors: David T. Hill, Blaine M. Sutton, Ivan Lantos
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Patent number: 4125710Abstract: Bis(triethylphosphine)gold salts are advantageous agents for preparing auranofin.Type: GrantFiled: June 30, 1977Date of Patent: November 14, 1978Assignee: Smithkline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4125711Abstract: Auranofin is prepared by reacting 1-.beta.-D-thio-2,3,4,6-tetra-O-acetylglucose with a triethylphosphine gold mercaptide.Type: GrantFiled: June 30, 1977Date of Patent: November 14, 1978Assignee: Smithkline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4124759Abstract: Auranofin is prepared by direct O-acetylation of S-triethylphosphinegold 1-thio-.beta.-D-glucopyranoside.Type: GrantFiled: June 30, 1977Date of Patent: November 7, 1978Assignee: SmithKline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4122254Abstract: Auranofin and its congeners are prepared by the reaction of a S-substituted 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose with a tertiary phosphine gold ester or sulfide.Type: GrantFiled: June 30, 1977Date of Patent: October 24, 1978Assignee: SmithKline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4115642Abstract: Auranofin and its congeners are prepared by reacting a bis(polyacetylsaccharide)disulfide with a tertiary phosphinegold mercaptide in a suitable organic solvent.Type: GrantFiled: June 30, 1977Date of Patent: September 19, 1978Assignee: SmithKline CorporationInventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
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Patent number: 4107425Abstract: Anomerically pure 1-.alpha.- and 1-.beta.-esters of 2,3,4,6-Tetra-O-benzyl-D-glucopyranose have been prepared in high yield by controlling the stereochemistry of 1-O-acylation of appropriately protected D-glucose. 2,3,4,6-tetra-O-benzyl-D-glucopyranose is metalated with n-butyllithium in either tetrahydrofuran or anhydrous benzene and the metalated product acylated with an appropriate alkyl, alkenyl, or aryl acid chloride. Hydrogenation of the acyl glucopyranose, when derived from a saturated acid chloride, yields the appropriate 1-.alpha.- or 1-.beta.-D-glucose ester. Reaction in tetrahydrofuran produces the .alpha.-anomer while reaction in anhydrous benzene produces the .beta.-anomer.Type: GrantFiled: February 15, 1977Date of Patent: August 15, 1978Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Philip E. Pfeffer, Gordon G. Moore
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Patent number: 4098884Abstract: Doxorubicin thioesters of the formula ##STR1## wherein R is acyl and which are useful in treating animal tumors, are prepared by reacting 14-bromo-daunomycin with a salt of a thioacid of the formula RSM wherein R is as defined above and M is an alkali metal atom or a quaternary ammonium salt in an inert polar solvent. The invention described herein was made in the course of work under a grant from the Department of Health, Education, and Welfare.Type: GrantFiled: March 10, 1977Date of Patent: July 4, 1978Assignee: Societa' Farmaceutici Italia S.p.A.Inventors: Federico Arcamone, Luigi Bernardi, Bianca Patelli
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Patent number: 4096249Abstract: The compounds are trialkylphosphinegold(I)2,3,4,6-tetra-O-(N-loweralkylcarbamoyl)-1-thio-.be ta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.Type: GrantFiled: February 16, 1977Date of Patent: June 20, 1978Assignee: SmithKline CorporationInventor: Ivan Lantos
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Patent number: 4096247Abstract: A new series of lower alkyl ethers of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranoside has been prepared and found to have anti-arthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.Type: GrantFiled: February 16, 1977Date of Patent: June 20, 1978Assignee: SmithKline CorporationInventor: Ivan Lantos
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Patent number: 4096321Abstract: A novel synthetic process to produce the antibiotic oxazinomycin is presented along with novel intermediates utilized in said process.Type: GrantFiled: November 22, 1976Date of Patent: June 20, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Manfred Weigele, Silvano DeBernardo
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Patent number: 4096250Abstract: The compounds are tri-substituted phosphinegold(I) 1-thio-.beta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally substituted phenyl and the others are lower alkyl or lower alkoxy.Type: GrantFiled: February 25, 1977Date of Patent: June 20, 1978Assignee: SmithKline CorporationInventor: David T. Hill
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Patent number: 4096248Abstract: A new series of lower alkyl sulfonyl esters of S-tri-lower-alkylphosphinegold 1-thio-.beta.-D-glucopyranosides has been prepared and found to have anti-arthritic activity and, in particular, are of use in treating rheumatoid arthritis.Type: GrantFiled: February 16, 1977Date of Patent: June 20, 1978Assignee: SmithKline CorporationInventor: Ivan Lantos
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Patent number: 4090013Abstract: A dry, solid, water-swellable, water-insoluble absorbent composition of matter comprises an ionic complex of a water-soluble anionic poly-electrolyte and a polyvalent metal cation. The composition is characterized by an ability to uncomplex at an elevated pH and recomplex at a lower pH.Type: GrantFiled: March 7, 1975Date of Patent: May 16, 1978Assignee: National Starch and Chemical Corp.Inventors: Stuart H. Ganslaw, Howard G. Katz
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Patent number: 4078139Abstract: The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group selected from the group consisting of an O-alkylthioester and an O-alkylselenoester with at least one mole of an organotin hydride, preferably tri-n-butylstannane, in an inert, aprotic solvent at a temperature of at least about 100.degree. C and under an inert atmosphere.The process is particularly useful in removing secondary alcohols in aminoglycoside antibiotics to produce deoxy derivatives thereof having antibacterial activity.Also described are novel O-sec.-alkylthiobenzoate, O-sec.-alkyl-S-methylxanthate, N-(sec.-alkoxythiocarbonyl)-imidazole esters, and di-O-alkylthiocarbonates having at least one secondary O-alkyl group, useful intermediates of the claimed process.Type: GrantFiled: July 12, 1976Date of Patent: March 7, 1978Assignee: Schering CorporationInventors: Derek H. R. Barton, Stuart W. McCombie
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Patent number: 4069104Abstract: A process for converting aldoses or derivatives thereof into ketoses or derivatives thereof which takes place in the presence of oxyanions or mixed complex oxyanions of germanium or tin which form stronger complexes with the ketoses or derivatives thereof than with the aldoses or derivatives thereof. Using the process the equilibrium position in the aldose-ketose reaction is shifted towards higher proportions of ketose. The process is very applicable to the conversion of glucose to fructose particularly when this conversion takes place enzymatically in the presence of glucose isomerase.Type: GrantFiled: June 17, 1976Date of Patent: January 17, 1978Assignee: Imperial Chemical Industries LimitedInventors: Sidney Alan Barker, Peter John Somers, Robin Ross Woodbury, Geoffrey Harry Stafford
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Patent number: 4043952Abstract: The aqueous dispersibility of a water-absorbent composition of matter is improved by a surface treatment which ionically complexes the surface thereof to a moderate degree. A dispersion is formed comprising a water-absorbent composition of matter based on an anionic poly-electrolyte, at least one polyvalent metal cation, and a dispersing medium in which the composition of matter is substantially insoluble. The dispersion is maintained within a given temperature range for a period of time sufficient to ionically complex the exposed surface of the composition of matter, and the dispersing medium is then removed. The product is characterized by a linkage density which is greater at the surface thereof than in the interior thereof and by the presence of ionic linkages at the surface thereof.Type: GrantFiled: May 9, 1975Date of Patent: August 23, 1977Assignee: National Starch and Chemical CorporationInventors: Stuart H. Ganslaw, Howard G. Katz