Starch Derivatives Patents (Class 536/45)
  • Patent number: 6887859
    Abstract: Disclosed are topical compositions, including methods of applying those compositions to absorb sweat and sebum from the skin, wherein the compositions comprise (A) fluid-absorbent solids having a Water Absorption Value of at least about 0.5 grams/gram; (B) an adhesive fluid; and (C) a liquid carrier; herein the composition has an Average Wear Index Value of at least about 60%. The topical compositions provide effective delivery and deposition of the fluid-absorbent solid onto the skin from an extended wear composition.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: May 3, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Mannie Lee Clapp, Rebecca Ann Taylor, Colin Michael McHugh, Jorge Max Sunkel, Timothy James Felts, Edward Dewey Smith, III, Scott William Syfert, Michael Joseph Roddy, Robert William Corkery
  • Patent number: 6872820
    Abstract: Finely divided polysacharide derivatives are described. The finely divided polysacharide derivatives are prepared by a process comprising: a) forming an aqueous composition comprising a polysaccharide derivative and water, in which the polysaccharide derivative is soaked or dissolved; b) converting the polysaccharide derivative of the aqueous composition into finely divided solid particles by, (i) contacting the aqueous composition with superheated water vapor in a dryer-pulverizer; or (ii) causing the polysaccharide derivative of the aqueous composition to flocculate; and c) optionally drying the finely divided solid particles of step b). The primary structures of the polysaccharide starting material are largely removed, and the product has a shape factor of less than 5 and greater than or equal to 1.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: March 29, 2005
    Assignee: Wolff Walsrode AG
    Inventors: Gunter Weber, Detmar Redeker, Bernd Klinksiek, Jürgen Hinderer, Benno Ulfik
  • Patent number: 6835718
    Abstract: This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other medical uses. Methods are also disclosed for preparing biocleavable cyclodextrin micelle carriers that release drugs under controlled conditions. The invention also discloses biocleavable or biodegradable micelle compositions that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: December 28, 2004
    Assignee: KK Biomed Corporation
    Inventor: Kenneth M. Kosak
  • Patent number: 6828310
    Abstract: Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a single reduced malto-oligosaccharide species or a plurality of such species. Further disclosed is a method of preserving a material. The method generally includes contacting the material with a preserving agent containing a preserving effective amount of one or more reduced malto-oligosaccharide species. Solutions, powders, glasses, gels, and the like containing the chemically reactive material(s) and a preserving effective amount of one or more reduced malto-oligosaccharide species may be prepared.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: December 7, 2004
    Assignee: Grain Processing Corporation
    Inventors: Frank W. Barresi, Richard L. Antrim
  • Patent number: 6803459
    Abstract: The present invention provides a starch that includes at least one glucose polymer having greater than 4% alpha 1-6 glycosidic linkages. The present invention further provides a starch hydrolyzate that includes at least one glucose oligomer having greater than 4% alpha 1-6 glycosidic linkages. The starch and starch hydrolyzate present invention have improved aqueous solution stability and are less likely to retrograde than are solutions of unbranched linear starches or starch hydrolyzates.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: October 12, 2004
    Assignee: Grain Processing Corporation
    Inventor: Richard L. Antrim
  • Publication number: 20040181053
    Abstract: The invention relates to a method for the modification of starch in such a way that it is suitable for surface sizing at high dry matter contents of >15%, typically >20%, even more than 25%. The modification of starch comprises at least degradation and stabilisation of the starch, whereby the degradation of starch is carried out by means of a chemical treatment, such as hypochlorite oxidation or acid treatment, to such a degree of degradation at which the viscosity of the surface size prepared from the starch, calculated to a dry matter content of 10% and to a temperature of 60° C., still is at >10 mPas, typically >20 mPas, most typically >25 mPas, Brookfield RVTD II 100 rpm. The invention also relates to a starch intended for use in surface sizing at a high dry matter content and its use in surface sizing.
    Type: Application
    Filed: February 27, 2004
    Publication date: September 16, 2004
    Inventors: Stig-Erik Bruun, Hannu Ketola, Timo Laine
  • Publication number: 20040180858
    Abstract: The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. The cytostatic agents daunorubicin and doxorubicin are highly cardiotoxic. The novel pharmaceutical forms are antibiotic-starch conjugates, wherein the antibiotic is combined with the polysaccharide at the reducing end thereof by means of a peptide bond. According to the invention, said bond is carried out by means of J2 oxidation of the starch derivative at the reducing end thereof in an aqueous alkaline solution, and by coupling the starch derivative oxidised thereby to the antibiotic in an organic solution. The conjugates obtained are less toxic. The polysaccharide part can be decomposed by serum-&agr;-amylase and the peptide bond can be accessed by an enzymatic attack.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 16, 2004
    Inventor: Klaus Sommermeyer
  • Publication number: 20040149412
    Abstract: As additive for the production of paper and board to improve the strength of a wet web a copolymer stabilized with a cationic polysaccharide is proposed in which copolymer an acrylamide of metacrylamide, vinylic carboxyl acid and optionally other vinylic monomers are used as monomers. The wet strength of a web means the strength of a paper or board web during production at a dry solids content of 20-60%. The additive according to the invention improves, in addition to the wet strength of the web, also the surface resistance of the product. Compared to the additives of the prior art, a small relative ratio of the number of the side chains to the cationic groups is used, because a polysaccharide having a higher cationic character has been found to provide better stability.
    Type: Application
    Filed: November 20, 2003
    Publication date: August 5, 2004
    Inventors: Anna-Liisa Tammi, Kari Nurmi
  • Patent number: 6770148
    Abstract: The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: August 3, 2004
    Assignee: Baxter International Inc.
    Inventors: Annamaria Naggi, Enrico Petrella, Giangiacomo Torri, Benito Casu
  • Publication number: 20040127697
    Abstract: Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 1, 2004
    Inventor: Paul K. Smith
  • Patent number: 6720418
    Abstract: Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the resulting hydrogenated malto-oligosaccharide is derivatized, such as via oxidation, esterification, etherification, or enzymatic modification. The derivatization of such hydrogenated malto-oligosaccharides results in a surprisingly low level of a formation of by-products and products of degradation. In a particularly preferred embodiment of the invention, a mixture of malto-oligosaccharides is catalytically hydrogenated under reaction conditions suitable to substantially preserve the degree of polymerization (DP) profile of the mixture. The resulting malto-oligosaccharide mixture then is derivatized to form a derivatized malto-oligosaccharide mixture.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: April 13, 2004
    Assignee: Grain Processing Corporation
    Inventors: Richard L. Antrim, Frank W. Barresi
  • Patent number: 6713624
    Abstract: A starch-based modeling compound includes a starch-based binder and about 2% to about 10% retrogradation inhibitor, such as waxy corn starch.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: March 30, 2004
    Assignee: Hasbro, Inc.
    Inventors: Linwood E. Doane, Jr., Lev Tsimberg
  • Patent number: 6710175
    Abstract: According to the present disclosure, starch/polymer combinations are provided. The preferred starch/polymer combinations are usable as paper additives, in the wet end of a papermaking process. Typical and preferred starch/polymer combinations of this type, result from combining a starch, having a polymer reactive carbonyl functionality, with a polymer, having a carbonyl reactive functionality, under conditions that allow for covalent interaction between the two. Typically usable components comprise oxidized starch and polymer having reactive primary or reactive secondary amine groups. Also provided are methods of preparing such combinations, methods of use, preferred papers including such combinations, and, analytical techniques usable in preparation of such combinations.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 23, 2004
    Inventors: Kevin Ray Anderson, Anton Esser, Lawrence Edward Fosdick, Ki-Oh Hwang, Norbert Mahr, John Thomas McDonald, Jr., Dogan Sahin Sivasligil, Andreas Stange, Sarah Veelaert, Martin Wendker
  • Patent number: 6703496
    Abstract: The invention relates to starch phosphates exhibiting improved properties with regard to application techniques, to a method for the production thereof, and to their use. Based on the disadvantages of the known prior art, the aim of the invention is to produce starch phosphates which have a high degree of substitution, which are resistant to hydrolysis, and which can be produced using phosphorylating agents comprising only a low level of toxicity. To this end, starch phosphates are provided in which the anhydroglucose units are substituted by phosphate ester groups and carbamide groups, and the average degree of substitution DS of the carbamide groups and of the phosphate ester groups is in a range, each time, that is greater than 0.01. The starting materials are used in a mol ratio of anhydroglucose units of the starch:phosphorus of the phosphorylating agent:urea of 1:0.1 to 1.5:0.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: March 9, 2004
    Inventors: Friedemann Pieschel, Eckehard Lange, Juan Camacho
  • Publication number: 20040030119
    Abstract: The invention relates to a method for producing starch solutions of high cation equivalent value (with a DS of 0.1-1.0). The starch to be cationized, advantageously an oxidized starch, is slurried to form a suspension of about 10-80% solids content in an aqueous mixture of a cationizing agent. In the cationization 2,3-epoxypropyltrimethylammonium chloride or an equivalent chlorohydrin-functional cationizing agent is used by about 90-1100 g per kg starch solids, and a catalyst is added to the slurry. The reaction is carried out at a high solids content of 40-80%, preferably 50-60%, in at least two successive steps, in the first of which a temperature of about 5-40 ° C. is maintained, and in the second step a temperature of about 70-180 ° C.
    Type: Application
    Filed: August 8, 2003
    Publication date: February 12, 2004
    Inventors: Antti Likitalo, Jouko Kaki
  • Patent number: 6635756
    Abstract: A starch obtained from a plant modified by manipulating the activity of a combination of plant enzymes having starch synthase activity, in particular starch synthase II (SSII) and starch synthase III (SSIII). Modified plants, their use as food products and starch, in particular obtained from a modified potato plant, having unexpected properties and uses thereof are also disclosed.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: October 21, 2003
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Stephen Alan Jobling, Roger John Westcott, Gerhard Peter Schwall, Catherine Rosemary Martin, Elizabeth Anne Edwards, Alison Mary Smith
  • Patent number: 6635755
    Abstract: The present invention relates to a polysaccharide having functional groups, wherein said groups are aldehyde groups formed at positions C2 and/or C3 as well as at position C6 of the anhydroglucose units of the polysaccharide chain. Preferably the polysaccharide is a cellulosic fibrous material whose primary and secondary hydroxyl groups of the cellulose are oxidized into aldehyde groups at least in part by means of TEMPO oxidation and periodate oxidation. The invention also concerns a paper or nonwoven comprising the above polysaccharide. According to the invention a relative wet strength of more than 10% can be achieved.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: October 21, 2003
    Assignee: SCA Hygiene Products GmbH
    Inventors: Thomas Jaschinski, Susanna Gunnars, Arie Cornelis Besemer, Petter Bragd
  • Publication number: 20030175230
    Abstract: The invention concerns a cosmetic use of at least a starch betainate for treating keratinous matter, in particular keratinous fibres and the skin, comprising said starch betainate combined with at least an agent beneficial for keratinous matter. The invention also concerns a cosmetic treatment method and a use of said composition, in particular as after-shampoo and hairstyling lotion.
    Type: Application
    Filed: January 17, 2003
    Publication date: September 18, 2003
    Inventor: Claude Dubief
  • Patent number: 6610672
    Abstract: Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a single reduced malto-oligosaccharide species or a plurality of such species. Further disclosed is a method of preserving a material. The method generally includes contacting the material with a preserving agent containing a preserving effective amount of one or more reduced malto-oligosaccharide species. Solutions, powders, glasses, gels, and the like containing the chemically reactive material(s) and a preserving effective amount of one or more reduced malto-oligosaccharide species may be prepared.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: August 26, 2003
    Assignee: Grain Processing Corporation
    Inventors: Frank W. Barresi, Richard L. Antrim
  • Patent number: 6610843
    Abstract: The present invention describes transgenic plant cells and plants which due to a reduced activity of a disproportionating enzyme (D enzyme) synthesize a modified starch. Furthermore, the starch synthesized in these plant cells and plants is described.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: August 26, 2003
    Assignee: Bayer CropScience GmbH
    Inventors: Jens Kossmann, Franziska Springer, Volker Büttcher
  • Patent number: 6593469
    Abstract: Disclosed is a composition that includes a material that is susceptible to degradation and a preserving agent in an amount effective to preserve the material comprising one or more reduced malto-oligosaccharide species. The preserving agent can include a single reduced malto-oligosaccharide species or a plurality of such species. Further disclosed is a method of preserving a material. The method generally includes contacting the material with a preserving agent containing a preserving effective amount of one or more reduced malto-oligosaccharide species. Solutions, powders, glasses, gels, and the like containing the chemically reactive material(s) and a preserving effective amount of one or more reduced malto-oligosaccharide species may be prepared.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: July 15, 2003
    Assignee: Grain Processing Corporation
    Inventors: Frank W. Barresi, Richard L. Antrim
  • Patent number: 6576617
    Abstract: A composition comprising a perishable material susceptible to spoilage from mold, fungus, or yeast growth and a natamycin material dispersed in or on the perishable material to provide the material protection from yeast, fungus, and mold growth.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: June 10, 2003
    Assignee: International Fiber Corporation
    Inventor: Jit F. Ang
  • Patent number: 6528629
    Abstract: Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an alcohol or a thiol under conditions suitable to form a malto-oligosaccharide derived glycoside. Also disclosed is a method for preparing a mixture of malto-oligosaccharide derived glycosides by providing a mixture of malto-oligosaccharides and glycosylating the malto-oligosaccharides with an alcohol or a thiol under substantially anhydrous conditions to form a mixture of malto-oligosaccharide derived glycosides.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: March 4, 2003
    Assignee: Grain Processing Corporation
    Inventors: Richard G. Rogers, Frank W. Barresi
  • Publication number: 20020170693
    Abstract: This invention relates to a degraded, inhibited cationic starch for use in papermaking systems, which affords improved physical properties, particularly strength. Additionally these derivatives provide easy-to-prepare alternatives to traditional starches, and can even be added directly to the papermaking process without cooking. While the benefits of these starch compositions can be applied to any type of papermaking method, they are especially useful in high shear, high conductivity and recycle systems.
    Type: Application
    Filed: March 13, 2001
    Publication date: November 21, 2002
    Inventors: Michele M. Merrette, John J. Tsai, Paul H. Richardson
  • Patent number: 6469161
    Abstract: A chemical fluidification process for a starchy material, which is carried out in a reactor suitable for continuous operation and with a humidity of the reaction mix (starch included) of less thank 25%, which consists in subjecting a starchy material to the hydrolyzing action of a chemical agent. The dwell time of the starchy material in the fluidification reactor is more than 5 minutes and less than 30 minutes. The temperature at the core of said reactor is more than 60° C. and less than 100° C. approximately, a conversion process comprising said chemical fluidification, and starchy materials obtainable by such processes.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: October 22, 2002
    Inventors: Patrick Fuertes, Anne Lambin
  • Publication number: 20020143160
    Abstract: 1.
    Type: Application
    Filed: March 6, 2002
    Publication date: October 3, 2002
    Applicant: NOF CORPORATION
    Inventors: Junzo Sunamoto, Kazunari Akiyoshi, Ryuzo Hosotani, Akio Hayashi, Hiroki Fukui
  • Patent number: 6455691
    Abstract: This invention describes improvements in or relating to the production of polysaccharide derivatives; more particularly it relates to a method of converting insoluble polysaccharides to a form in which they form part of an anhydrous system in which they may be used as chemical intermediates in the production of derivatives.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: September 24, 2002
    Assignee: University of Wales, Bangor
    Inventor: Daniel Richard Hlynianski
  • Patent number: 6436237
    Abstract: A method for preparing a cationic cross-bonding reagent wherein the amount of cross-bonding impurities is determined and a certain quantity of a cross-bonding agent is added. This cationic cross-bonding reagent is used in a process for preparing cationic cross-bonded starches with tailor-made viscosity and excellent viscosity stability. Products with tailor-made viscosity can be used according to their need in specific applications in the wet-end of papermaking.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: August 20, 2002
    Assignee: Cerestar Holding B.V.
    Inventors: Marc Charles Florent Berckmans, Detlev Glittenberg, Johannes Felix Hintermayer
  • Patent number: 6398912
    Abstract: The object of the invention is an additive for paper making by means of which the dusting tendency of paper can be reduced. The agent is based on starch, the molecular size of which has been reduced, and which has been cationized to a charge of less than 1.5 mEkv/g with a quaternary nitrogen compound. The agent is added to the fiber pulp for paper making prior to web formation.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: June 4, 2002
    Assignee: Raisio Chemicals Ltd.
    Inventors: Tapio Vihervaara, Kari Luukkonen, Veikko Niinivaara
  • Patent number: 6391863
    Abstract: The use of carbohydrate derivatives in or for making a topical composition for promoting skin exfoliation is disclosed. The use of said composition of controlling intrinsic and extrinsic skin ageing, as well as a non-therapeutic skin treatment method for skin exfoliation, are also disclosed.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: May 21, 2002
    Assignee: L'Oreal
    Inventors: Michel Philippe, Catherine Ebenhan-Nappe
  • Patent number: 6380379
    Abstract: Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the resulting hydrogenated malto-oligosaccharide is derivatized, such as via oxidation, esterification, etherification, or enzymatic modification. The derivatization of such hydrogenated malto-oligosaccharides results in a surprisingly low level of a formation of by-products and products of degradation. In a particularly preferred embodiment of the invention, a mixture of malto-oligosaccharides is catalytically hydrogenated under reaction conditions suitable to substantially preserve the degree of polymerization (DP) profile of the mixture. The resulting malto-oligosaccharide mixture then is derivatized to form a derivatized malto-oligosaccharide mixture.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: April 30, 2002
    Assignee: Grain Processing Corporation
    Inventors: Richard L. Antrim, Frank W. Barresi
  • Patent number: 6375798
    Abstract: Disclosed is a method for derivatizing a malto-oligosaccharide. The method includes the steps of providing the malto-oligosaccharide and derivatizing the malto-oligosaccharide in an aqueous medium with a cationic agent to form a derivatized malto-oligosaccharides. Malto-oligosaccharides having a high DS sufficient to render the derivatized product suitable for use as a trash scavenger are attainable in accordance with the present inventive method. Also disclosed are a method for trash scavenging, a process for preparing a paper web, in which anionic trash is scavenged prior to withdrawing a paper web from a pulp furnish; and a paper web prepared in accordance with the present inventive process.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: April 23, 2002
    Assignee: Grain Processing Corporation
    Inventors: Adrian P. Kightlinger, Stuart W. Mabee
  • Patent number: 6361935
    Abstract: Broadly, the present invention relates to mutating starch genes in polyploid cereal grains. Specifically, this invention concerns mutant wheat plants, mutant wheat grain and the starch therefrom.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: March 26, 2002
    Assignee: ExSeed Genetics LLC
    Inventors: Peter L. Keeling, Francie G. Dunlap, Ming Chang
  • Patent number: 6265570
    Abstract: Stable, cold water soluble, ready for use starch aldehyde compositions and the method of preparation of such compositions wherein an aqueous dispersion of a converted starch acetal is hydrolyzed under acidic conditions to form the starch aldehyde which is then spray dried into a cold water soluble starch aldehyde powder.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: July 24, 2001
    Assignee: National Starch & Chemical Investment Holding Corporation
    Inventors: A. Levent Cimecioglu, Bjork Ohlhorst, Daniel B. Solarek, Douglas J. Slate, James L. Eden
  • Patent number: 6207176
    Abstract: This invention involves skin cleaning products and tapes for removing keratotic plugs, dirt and other debris found on the skin and in skin pores and comprising a starch based remoistenable adhesive composition wherein the starch has from about 0 to 70% by weight amylose content and is converted to from about 30 WF to 20 DE.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: March 27, 2001
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Doreen L. Howard, Frank A. Nowak, Jr., Daniel B. Solarek, James L. Eden, Gary T. Martino
  • Patent number: 6197951
    Abstract: The invention discloses a starch graft poly(meth)acrylate blast media which is effective in paint removal. The media is superior to a physical blend of the components (i.e., starch and acrylic polymers) and to either a starch polymer or an acrylic polymer used singly. The hardness of the media is between 65-90 Shore D.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: March 6, 2001
    Assignee: Archer Daniels Midland Company
    Inventor: Ruben P. Lenz
  • Patent number: 6184272
    Abstract: A fiber-reinforced molded plastic part, a process for its manufacture and a use. The fiber-reinforced molded plastic part consists of a plastic matrix with natural fibers particularly arranged in a uniformly distributed manner in the plastic matrix. The plastic matrix has at least two mutually mixed polymers, of which one is a biopolymer and the other is a polymer which is at least largely resistant to biological stress.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: February 6, 2001
    Assignee: DiamlerChrysler AG
    Inventors: Thomas Foelster, Ralph Greiner, Dirk Schaefer
  • Patent number: 6127348
    Abstract: The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: October 3, 2000
    Assignee: Gliatech, Inc.
    Inventors: Dikla Roufa, Adrian Harel, Robert C. A. Frederickson, George T. Coker, III
  • Patent number: 6123738
    Abstract: 2,3-Epoxypropyltrimethylammonium chloride having reduced color and method of preparation are disclosed. 2,3-Epoxypropyltrimethylammonium chloride is treated with sodium hypochlorite to reduce its color. 2,3-Epoxypropyltrimethylammonium chloride can be prepared via reaction of trimethylamine and epichlorohydrin. If desired, an aprotic solvent can be used. 2,3-Epoxypropyltrimethylammonium chloride formed in the resultant slurry, must then be isolated via known methods, such as evaporation, extraction, centrifugation, etc, depending upon the other constituents of the slurry and the residual epichlorohydrin removed. The final product is then treated with an effective amount of sodium hypochlorite. The obtained 2,3-epoxypropyltrimethylammonium chloride then is used for, for example, color-sensitive applications such as to produce cationic starch for use in paper manufacture.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: September 26, 2000
    Assignee: The Dow Chemical Company
    Inventors: Laren P. Childers, Dorothy L. Roerden
  • Patent number: 6103885
    Abstract: The Invention pertains to a process for the amidation of a material having at least one carboxyl-containing polysaccharide. The provided process involves a first step in which the carboxyl groups are reacted with an ammonium donor of the general formula >NH to form the corresponding polysaccharide carboxyl ammonium salt, and a second step in which the polysaccharide carboxyl ammonium salt is heated so as to convert the ammonium groups into the corresponding amido groups. The invention also pertains to fatty amide modified carboxyl-containing polysaccharides, and particularly to fatty amide modified carboxymethyl cellulose. The products in accordance with the invention can be widely employed, e.g. in the field of biodegradable plastics, as anti-redeposition agents for synthetic fibers, as polymeric emulsifiers, as pigment dispersing agents, in cosmetic applications, as thickeners, as oil drilling fluids, as superabsorbers, and in mineral processing.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: August 15, 2000
    Assignee: Akzo Nobel NV
    Inventors: Jan Gerardus Batelaan, Peter Marten Van Der Horst
  • Patent number: 6063914
    Abstract: The aging of swellable starch maleates is reduced by reacting with one or more singly and/or multiply functional nucleophiles as in a Michael condensation reaction. Mixtures of mercaptoethanol and 1,2-bis-(2-mercaptoethoxy)-ethane or mixtures of sodium bisulfite and pentaerythrite-tetrakis-(2-mercaptoacetate) are preferred. The decrease of the retention capacity [SRV] in the reaction products after 100 days is preferably <10%. The products find use as biodegradable, non-aging superabsorbers.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: May 16, 2000
    Assignee: Stockhausen GmbH & Co. KG
    Inventors: Heiko Wolf, Klaus Dorn, Thomas Eurich
  • Patent number: 6037466
    Abstract: A method for preparing hydrophobic starch derivatives wherein starch and an anhydride are reacted in a slurry with the anhydride reagent being added to the slurry in pre-emulsified form to provide a significantly faster and more efficient reaction.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: March 14, 2000
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Walter Maliczyszyn, Jeffrey G. Atkinson, Maria Tolchinsky
  • Patent number: 5994532
    Abstract: The use of amylopectin-type starch obtained from potato that has been subjected to a genetical engineering modification to suppress the formation of amylose-type starch, as a finishing agent in papermaking is described.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: November 30, 1999
    Assignee: Sveriges Starkelseproducenter, Forening Upa
    Inventor: Olle Wikstrom
  • Patent number: 5948904
    Abstract: The invention relates to a process for the preparation of polysaccharide-N-arylcarbamates in suitable form as supports for chromatography, which process comprises adding to polysaccharide carbamates, which may be substituted in the aryl moiety, an N-aryl-1-lower-alkylcarbamate-containing solution of an organic solvent, with vigorous stirring, until the polysaccharide derivative is completely dissolved and then adding thereto an aqueous solution containing a high molecular weight surfactant and, with continued stirring, removing the organic solvent from the emulsion so obtained and isolating the solid particles and washing and drying them. The polysaccharide derivatives so obtained can be used as support materials for the chromatographic separation of enantiomers.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 7, 1999
    Assignee: Novartis AG
    Inventor: Eric Francotte
  • Patent number: 5945528
    Abstract: Disclosed is the production of starch decomposition products with a narrow molecular weight distribution, based on the treatment of starch or starch derivatives using high-pressure homogenization. The starch decomposition products are obtained in high yields with a narrow molecular weight distribution.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: August 31, 1999
    Assignee: Fresenius AG
    Inventors: Klaus Sommermeyer, Michael Gorg, Klaus Henning
  • Patent number: 5883242
    Abstract: The present invention provides a cationic starch prepared by roasting starch under the presence of a cationic polymer, a method for preparing the cationic starch, and a method for making paper board with the cationic starch. The method for making paper board of the present invention provides high retention of starch in paper board, enhances paper board strength in a high level and reduces a load of treating waste water from a paper machine, in comparison with the starch which has conventionally been employed for paper making.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: March 16, 1999
    Assignee: Sanwa Cornstarch Co., Ltd.
    Inventors: Satoshi Kubota, Akitomo Terada, Yoshiteru Yamamoto
  • Patent number: 5856467
    Abstract: Genetically engineered modification of potato for suppressing formation of amylopectin-type starch is described.The invention describes an antisense construct for inhibiting, to a varying extent, the expression of the gene coding for formation of branching enzyme (BE gene) in potato, said antisense construct comprising a tuber-specific promoter, transcription start and the first exon of the BE gene, inserted in the antisense direction.Also cells, plants, tubers, microtubers and seeds of potato comprising said antisense construct are described.Finally, amylose-type starch, both native and derivatized, derived from the potato that is modified in a genetically engineered manner, as well as a method of suppressing amylopectin formation in potato are described.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 5, 1999
    Assignee: Amylogene HB
    Inventors: Per Hofvander, Per T. Persson, Anneli Tallberg, Olle Wikstrom
  • Patent number: 5834446
    Abstract: Nerve process growth modulation can be achieved using derivatized cyclodextrins. Processes for making sulfated and aminated .beta.-cyclodextrin derivatives are also described in which a compound of the formula R".sub.2 NCH X'.sup.+ X'.sup.- where R.sup.- is an alkyl containing 1-5 carbon atoms and X is selected from bromine and iodine is used to halogenate the cydodextrin.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: November 10, 1998
    Assignee: Queen's University at Kingston
    Inventors: Kimberly E. Dow, Boris I. Gorine, Richard J. Riopelle, Gregory Thatcher
  • Patent number: 5824798
    Abstract: Genetically engineered modification of potato for suppressing formation of amylose-type starch is described.Three fragments for insertion in the antisense direction into the potato genome are also described. Moreover, antisense constructs, genes and vectors comprising said antisense fragments are described. Further a promoter for the gene coding for formation of granule-bound starch synthase and also the gene itself are described.Also cells, plants, tubers, microtubers and seeds of potato comprising said antisense construct are described.Finally, amylopectin-type starch, both native and derivatized, derived from the potato that is modified in a genetically engineered manner, as well as a method of suppressing amylose formation in potato are described.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 20, 1998
    Assignee: Amylogene HB
    Inventors: Anneli Tallberg, Per Hofvander, Per T. Persson, Olle Wikstrom
  • Patent number: 5811236
    Abstract: Electrochemiluminiscent moieties having the formula?Re(P).sub.m (L.sup.1).sub.n (L.sup.2).sub.o (L.sup.3).sub.p (L.sup.4).sub.q (L.sup.5).sub.r (L.sup.6).sub.s !.sub.t (B).sub.uwhereinP is a polydentate ligand of Re;L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5 and L.sup.6 are ligands of Re, each of which may be the same as or different from each other ligand;B is a substance which is a ligand of Re or is conjugated to one or more of P, L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5 or L.sup.6 ;m is an integer equal to or greater than 1;each of n, o, p, q, r and s is zero or an integer;t is an integer equal to or greater than 1; andu is an integer equal to or greater than 1;P, L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5, L.sup.6 and B being of such composition and number that the chemical moiety can be induced to emit electromagnetic radiation and the total number of bonds to Re provided by the ligands of Re being equal to the coordination of Reare disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 22, 1998
    Assignee: IGEN International, Inc.
    Inventors: Richard J. Massey, Michael J. Powell, Walter J. Dressick, Jonathan K. Leland, Janel K. Hino, Mohindar S. Poonian, Leopoldo Della Ciana