Glucosamine Containing Patents (Class 536/55.2)
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Patent number: 8193325Abstract: The present invention relates a processing method for nano-miniaturizing chitosan of modifying property, which degrades the chitosan of high molecular weight down to the chitosan of middle and low molecular weight, then primarily nano-miniaturizes the interim chitosan by quaternary ammonium salt/synthesis, finally yield the nano-miniaturized chitosan of modified property by sol-gel method to have features in good biocompatibility and bioactivity to be served as additive material in products of cosmetics, medical treatment, hygiene, health care, biomedicine, agriculture, textile, food and so like so that not only the antiseptic, moisture-retentive and deodorizing capabilities can be promoted but also the processing cost can be reduced due to easiness of the mass production.Type: GrantFiled: December 31, 2008Date of Patent: June 5, 2012Assignee: Acelon Chemical and Fiber CorporationInventors: Wen-Tung Chou, Ming-Yi Lai, Kun-Shan Huang, Wei-Chun Chen
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Patent number: 8183229Abstract: Provided is a bone filling complex and method of preparing the same. The bone filling complex includes a matrix including a hydrogel-type hyaluronic acid derivative; and a bone derivative filling the matrix For example, the bone filling complex can be used to regenerate an injured alveolar bone.Type: GrantFiled: August 27, 2007Date of Patent: May 22, 2012Assignees: Megagen Implant Co., Ltd., Pohang University of Science and Technology Dept. of Advanced Materials Science & EngineeringInventors: Sei Kwang Hahn, Eun Ju Oh, Jung Kyu Park, Kwang Bum Park, Kyoung Ho Ryoo, Seok Kyu Choi, Dong Jun Yang, Hyun Wook An
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Patent number: 8163716Abstract: Disclosed is a method for the amelioration of osteophyte formation including administering to a subject a therapeutically effective amount of an exogenous hyaluronan formulation.Type: GrantFiled: June 16, 2009Date of Patent: April 24, 2012Inventor: James D. Smith
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Publication number: 20120095204Abstract: A method to prepare D-glucosamine hydrochloride, obtaining product from raw material of citric acid residue from citric acid production by means of fermentation, and through processes of hydrolysis, suction filtering, concentration etc. Due to recovery of the citric acid residue, the present invention alleviates the environment pollution caused by the residue; Moreover, the D-glucosamine hydrochloride product produced from the raw material of citric acid residue is vegetarian D-glucosamine hydrochloride, without fishy odor and heavy metal pollution, safe and environment-friendly, with product purity up to 98-102%, and in line with the U.S.Type: ApplicationFiled: October 14, 2010Publication date: April 19, 2012Inventors: Jianguo BAI, Degui WANG, Jian WANG
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Patent number: 8093227Abstract: A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I.Type: GrantFiled: August 1, 2008Date of Patent: January 10, 2012Assignee: Alchemia Pty LtdInventors: Michael Leo West, Wim Meutermans, George Adamson, Karl Schafer, Darren Schliebs
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Publication number: 20110319358Abstract: Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of fermented fungal biomass are also disclosed.Type: ApplicationFiled: September 2, 2011Publication date: December 29, 2011Inventors: Lawrence E. Fosdick, John A. Bohlmann, James R. Trinkle, Brenda L. Ray
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Patent number: 8080641Abstract: The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products containing them and their uses in medical and pharmaceutical and cosmetic applications.Type: GrantFiled: March 23, 2009Date of Patent: December 20, 2011Assignee: Mentor Worldwide LLCInventor: Xiaobin Zhao
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Patent number: 8071756Abstract: A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoroactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyaffinity.Type: GrantFiled: September 10, 2004Date of Patent: December 6, 2011Assignee: Seikagaku CorporationInventor: Tomoya Sato
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Patent number: 8039447Abstract: The present invention relates to the use of a compound having the formula (I) wherein: n represents an integer varying from 720 to 6 200, and i varies from 1 to n, Ri represents in particular OH, or a group of the formula (III) wherein k represents an integer varying from 1 to 17, and R?i represents a linear or branched alkyl chain comprising p carbon atoms, wherein p is an integer varying from 1 to 17, with the proviso that k+p is not greater than 28, and preferably not greater than 20, and wherein at least one Ri group represents a group of formula (III), for the preparation of a viscoelastic composition.Type: GrantFiled: November 16, 2006Date of Patent: October 18, 2011Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Agro Industrie Recherches et Developpements A.R.D.Inventors: Marguerite Rinaudo, Rachel Auzely, Shirin Kadi, Anthony Bresin, Erell Kubik
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Patent number: 8034925Abstract: Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of fermented fungal biomass are also disclosed.Type: GrantFiled: March 18, 2010Date of Patent: October 11, 2011Assignee: Cargill, IncorporatedInventors: Lawrence E. Fosdick, John A. Bohlmann, James R. Trinkle, Brenda L. Ray
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Publication number: 20110237788Abstract: A proliferation inhibitor of H. pylori bacteria comprising a compound that can specifically inhibit the proliferation of H. pylori bacteria, which does not generate bacterium resistant, can be eaten, drunken or administrated safely for a long period of time, can be simply mass-manufactured and can be used for foods and beverages or pharmaceutical preparation. The proliferation inhibitor of H. pylori bacteria comprises an N-acetylglucosaminyl beta-linked monosaccharide derivative represented by the following chemical formula (1): GlcNAc1-beta-O—Y??(1) wherein Y is an alkyl group, an alkoxyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, a heteroaryl group, a carboxyl group or an alkoxycarbonyl group.Type: ApplicationFiled: October 9, 2009Publication date: September 29, 2011Applicant: THE NOGUCHI INSTITUTEInventors: Jun Nakayama, Takashi Shirai, Takashi Yamanoi, Masaya Fujita, Masako Mori
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Patent number: 8026221Abstract: A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a complex of the NLV with the antigen; and detecting the antigen-NLV complex. The antigen-NLV complex can be detected by contacting the NLV-antigen complex with a NLV antibody that binds at an epitope of the NLV, and detecting the NLV antibody. The invention also includes a method for identifying compounds, and the compounds, that can inhibit the binding between a Norwalk-Like Virus (NLV) and a histo-blood group antigen.Type: GrantFiled: February 29, 2008Date of Patent: September 27, 2011Assignees: Children's Hospital Medical Center, INSERMInventors: Xi Jiang, Jacques Le Pendu
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Patent number: 8013132Abstract: The present invention relates to synthetic compounds that are active on plants, especially as legume nodulation factors, and also as plant growth stimulators, and to methods for preparing such compounds, which are of formula (I).Type: GrantFiled: September 30, 2009Date of Patent: September 6, 2011Assignees: Bayer SAS, Institute National de la Recherche Agronomique, Centre National de la Recherche ScientifiqueInventors: Jean-Marie Beau, Jean Denarie, Alfred Grenier, Nathalie Grenouillat, Fabienne Maillet, Boris Vauzeilles
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Patent number: 8012913Abstract: A new class of sulfur scavenging or converting compositions is disclosed comprising diamine terminated, amine-aldehyde adducts, where the adducts are substantially bimolecular amine-aldehyde adducts and the composition is substantially free of trimer and/or triazines. Methods for making and using the new class of sulfur scavenging or converting composition are also disclosed.Type: GrantFiled: October 10, 2006Date of Patent: September 6, 2011Assignee: Clearwater International LLCInventors: Larry W. Gatlin, Daniel R. Dostie, Timothy Eric Gatlin
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Patent number: 8008275Abstract: A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate selective proliferation of mammalian natural killer (NK) cells and ??T cells. These compounds are useful as pharmaceuticals, particularly as immunostimulants, e.g., in the treatment of cancer and viral infections.Type: GrantFiled: October 2, 2008Date of Patent: August 30, 2011Inventor: Gradimir Misevic
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Publication number: 20110207147Abstract: Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.Type: ApplicationFiled: February 10, 2011Publication date: August 25, 2011Inventors: JOHN C. JEWETT, Carolyn Ruth Bertozzi, Ellen May Sletten, Chelsea Gloria Gordon
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Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
Patent number: 8003782Abstract: The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers and prevent and treat numerous other conditions and diseases. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion, metastatic and coronary cascades.Type: GrantFiled: February 1, 2000Date of Patent: August 23, 2011Assignee: Dermal Research Laboratories, Inc.Inventors: Harold G. Brown, Carol A. Cooper, Kristina J. Hennessy, Karen K. Brown -
Publication number: 20110189708Abstract: An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.Type: ApplicationFiled: August 7, 2009Publication date: August 4, 2011Applicants: HIROSAKI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGYInventors: Katsuya Yamada, Hideaki Matsuoka, Tadashi Teshima, Toshihiro Yamamoto
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Publication number: 20110177614Abstract: The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.Type: ApplicationFiled: January 14, 2011Publication date: July 21, 2011Inventors: Ajit Varki, Richard B. Schwab, Vered Padler-Karavani, Nancy Hurtado-Ziola
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Publication number: 20110171136Abstract: This invention relates to optical imaging probes and the use of such probes for diagnosing and monitoring disease, and disease treatment. The optical imaging probes of the current invention can be used to identify and characterize normal and diseased tissues with regards to altered metabolic activity.Type: ApplicationFiled: August 22, 2008Publication date: July 14, 2011Inventors: Kirtland G. Poss, Karen N. Madden, Ella Jones, Sylvie Kossodo
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Publication number: 20110171319Abstract: Nutritional compositions, formulations, and intermediates are provided which may be utilized to formulate various sweeteners and other products. The formulations described herein are made from constituents found in soils or fossilized soils.Type: ApplicationFiled: November 8, 2010Publication date: July 14, 2011Inventors: Albert Duoibes, Carl Nannini
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Publication number: 20110166339Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallisation of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.Type: ApplicationFiled: July 15, 2009Publication date: July 7, 2011Applicant: GLYCOM A/SInventors: Gyula Dekany, Karoly Agoston, Istvan Bajza, Marie Bøjstrup, Ignacio Fegueroa Pérez, Lars Kröger, Christoph H. Röhrig
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Publication number: 20110150999Abstract: Organo-soluble chitosan salts, method for preparing organo-soluble salts, chitosan-derived materials prepared with organo-soluble chitosan salts, and methods for preparing chitosan-derived materials are disclosed.Type: ApplicationFiled: April 1, 2009Publication date: June 23, 2011Inventors: Chih-Chang Chu, Chao Zhong
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Publication number: 20110150880Abstract: The invention relates to the compositions of synthetic oligo-?-(1?6)-2-amino-2-deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same.Type: ApplicationFiled: July 21, 2009Publication date: June 23, 2011Applicant: The Brigham and Women's Hospital, Inc.Inventors: Gerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
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Patent number: 7951936Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.Type: GrantFiled: October 29, 2007Date of Patent: May 31, 2011Assignee: Seikagaku CorporationInventor: Tomoya Sato
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Patent number: 7947662Abstract: The present invention relates to folates, compositions and uses thereof; In particular, this invention describes a crystalline or amorphous compound which is a substituted or unsubstituted folate or a reduced folate, or the natural or unnatural isomers thereof, of at least one organic base, as well as compositions and uses thereof. The compounds of the invention show a long lasting stability as well as a peculiarly high water-solubility.Type: GrantFiled: February 20, 2008Date of Patent: May 24, 2011Assignee: GNOSIS S.p.A.Inventors: Ermanno Valoti, Davide Bianchi, Marco Valetti
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Publication number: 20110110914Abstract: Methods and formulations for treating oncological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.Type: ApplicationFiled: May 11, 2010Publication date: May 12, 2011Inventors: Niven Rajin Narain, John Patrick McCook, Rangaprasad Sarangarajan
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Patent number: 7928090Abstract: An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined; and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.Type: GrantFiled: October 23, 2009Date of Patent: April 19, 2011Assignee: Lion CorporationInventors: Hiroaki Kambayashi, Hiroshi Konta
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Publication number: 20110077193Abstract: The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars, and isomers and salts thereof (formula I).Type: ApplicationFiled: December 1, 2010Publication date: March 31, 2011Applicant: BIODERM RESEARCHInventor: Shyam K. Gupta
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Patent number: 7906633Abstract: The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock. Also provided are synthetic intermediates useful for implementing the inventive methods.Type: GrantFiled: February 18, 2004Date of Patent: March 15, 2011Assignee: Eisai R&D Management Co., Ltd.Inventor: RuLin Fan
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Patent number: 7893225Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.Type: GrantFiled: January 30, 2002Date of Patent: February 22, 2011Assignee: Seikagaku CorporationInventor: Tomoya Sato
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Publication number: 20110034413Abstract: The present invention provides novel Quercetin derivatives of formula (I) and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1 is hydrogen, benzyl or substituted benzyl; R2 is hydrogen, benzyl or substituted benzyl, linear or branched (C1-C6) alkyl, substituted alkyl, aryl, substituted aryl, heterocycle and substituted heterocycle, useful for treatment of various disorders including cancer, multi-drug resistant cancers, viral infections etc. The invention also provides a process for the preparation of compounds of formula (I) and pharmaceutical compositions comprising the same.Type: ApplicationFiled: August 8, 2008Publication date: February 10, 2011Inventors: Narendra Shriram Joshi, Pawan Aggarwal, Vitthalbhai Ketan Hirpara, Manu Jaggi, Anu Singh, Anshumali Awasthi, Ritu Verma
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Publication number: 20110008444Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.Type: ApplicationFiled: February 13, 2009Publication date: January 13, 2011Applicant: IPR-SYSTEMS SWEDEN ABInventors: Kristoffer Bergman, Tim Bowden, Thomas Engstrand, Jons Hilborn, Dmitri Ossipov
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Patent number: 7858595Abstract: Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a ? 1-3 or ? 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.Type: GrantFiled: September 25, 2002Date of Patent: December 28, 2010Assignee: N.V. NutriciaInventors: Bernd Stahl, Berndt Finke, Joachim Schmitt, Werner Goebel, Jörg Slaghuis
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Patent number: 7855188Abstract: The present invention relates to the quaternized amino glucosamine, it can exert an anticancer effect via induction of apoptosis in a dose and time dependant manner through which an anticancer treatment effect can be increased.Type: GrantFiled: September 14, 2006Date of Patent: December 21, 2010Assignee: Pukyong National University Industry-Academic Cooperation FoundationInventors: Moon-Moo Kim, Se-Kwon Kim, Eresha Mendis
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Publication number: 20100311654Abstract: The present disclosure provides compositions for enhanced delivery of therapeutic agents. Drug delivery vehicle compositions may include a modified polysaccharide (e.g. chitosan) having at least one secondary amine or at least one tertiary amine and a therapeutic agent such as a therapeutic nucleic acid and/or a therapeutic anionic agent. Various additional modifications of a modified polysaccharide of the disclosure are also described. Exemplary therapeutic agents may include but are not limited to nucleic acids, polynucleotides, siRNA and/or pDNA. Compositions of the disclosure may be formulated as nanoparticles and may provide one or more advantages including efficient transfection, bio-delivery, availability, buffering ability, serum stability. Methods for synthesizing the drug delivery compositions are also set forth. The disclosure also provides methods for delivering/administering therapeutic agents using the drug delivery compositions of the disclosure to a patient in need thereof.Type: ApplicationFiled: March 9, 2010Publication date: December 9, 2010Inventors: Krishnendu Roy, Bilal Ghosn, Sudhir Kasturi
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Patent number: 7846914Abstract: A composition and method for pain relief and the treatment and prevention of endothelial dysfunction the cause of atherosclerosis, cardiovascular disease, hypertension, and stroke in mammals comprising a therapeutically effective amount of anti-inflammatory agents comprising; NSAIDs, an amino sugar and a zinc compound combined with dietary supplements that may enhance longevity.Type: GrantFiled: February 15, 2005Date of Patent: December 7, 2010Assignee: Advanced Medical InstrumentsInventor: Edward J. Petrus
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Publication number: 20100303852Abstract: The present application describes a process for conjugating a PNAG which is less than 40% N-acetylated to a carrier protein.Type: ApplicationFiled: March 29, 2007Publication date: December 2, 2010Inventors: Ralph Leon Biemans, Pierre Duvivier, Tomas Maira-Litran
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Patent number: 7838510Abstract: The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumor proliferation (in primary and secondary tumors) is disclosed.Type: GrantFiled: January 7, 2003Date of Patent: November 23, 2010Assignees: Fidia Farmaceutici S.P.A., Deutsches KrebsforschungszentrumInventors: Norbert E. Fusenig, Hans-Jürgen Stark, Michael Willhauck, Alessandra Pavesio
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Publication number: 20100273734Abstract: The present invention relates to methods for preparing a derivative of a hyaluronic acid, comprising: (a) mixing a liquid solution comprising the hyaluronic acid and a diamine, a polyamine, or a combination thereof, at a pH suitable to form an imine; (b) reducing the imine to an amine with a reductant at a pH suitable to produce the derivative of the hyaluronic acid; and (c) recovering the derivative of the hyaluronic acid. The present invention also relates to isolated derivatives of a hyaluronic acid, comprising the hyaluronic acid and a diamine, a polyamine, or a combination thereof.Type: ApplicationFiled: February 28, 2007Publication date: October 28, 2010Applicant: Novozymes Biopolymer A/SInventor: Feng Xu
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Patent number: 7816514Abstract: Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of fermented fungal biomass are also disclosed.Type: GrantFiled: October 13, 2003Date of Patent: October 19, 2010Assignee: Cargill, IncorporatedInventors: Lawrence E. Fosdick, John A. Bohlmann, James R. Trinkle, Brenda L. Ray
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Publication number: 20100247461Abstract: Disclosed are certain complexes of AFC compounds and binding agents. Such complexes are useful, among other things, in the treatment of inflammatory diseases or disorders.Type: ApplicationFiled: January 20, 2010Publication date: September 30, 2010Applicant: Signum Biosciences, Inc.Inventors: Michael Voronkov, Jeffry B. Stock, Maxwell Stock, Seung-Yub Lee, Eduardo Perez, Joel S. Gordon
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Publication number: 20100227836Abstract: Materials and methods for local delivery of a glucosamine are provided to facilitate bone and cartilage growth.Type: ApplicationFiled: September 30, 2009Publication date: September 9, 2010Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: JENNIFER H. ELISSEEFF, SHYNI VARGHESE, JEANNINE COBURN, MATTHEW GIBSON, ZAYNA NAHAS, ZHAOYANG YE
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Publication number: 20100222566Abstract: Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of fermented fungal biomass are also disclosed.Type: ApplicationFiled: March 18, 2010Publication date: September 2, 2010Inventors: Lawrence E. Fosdick, John A. Bohlmann, James R. Trinkle, Brenda L. Ray
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Patent number: 7776842Abstract: The present invention includes amino sugar chelates and methods for preparing amino sugar chelates of the formula given below, where M is a metal; R2 and R3 are independently selected from H, OH and hydroxyl substituted C1-C8 alkyl; R4 is selected from H, CO2H, OH, and hydroxyl substituted C1-C8 alkyl; each R5 is independently selected from H, OH, and hydroxyl substituted C1-C8 alkyl; A is selected from CH and O; a is from 0-6; b is from 0-6; n is from 1 to 8. The amino sugar chelates may include matrix stabilizing salts. The compounds and compositions disclosed can be used as nutritional supplements to impart health benefits.Type: GrantFiled: August 23, 2006Date of Patent: August 17, 2010Assignee: Albion Laboratories, Inc.Inventors: Clayton Ericson, DeWayne Ashmead, Stephen D. Ashmead, Amanda Rees
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Patent number: 7777027Abstract: The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone growth is desirable. In the invention methods beta glucans are administered so as to enhance the development of osteoblasts and the inhibition of the development and recruitment of osteoclasts. The inhibition of the recruitment and development of osteoclasts, coupled with the enhancement of osteoblast maturation by beta glucans leads to decreased bone resorption and increased bone formation, making beta glucans ideal agents for the treatment of osteoporosis and other bone resorption diseases.Type: GrantFiled: April 14, 2008Date of Patent: August 17, 2010Assignee: Immudyne, Inc.Inventors: Arun K. Bahl, Sharon V. Vercellotti, John R. Vercellotti, Elias Klein
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Patent number: 7763595Abstract: An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined; and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.Type: GrantFiled: October 24, 2008Date of Patent: July 27, 2010Assignee: Lion CorporationInventors: Hiroaki Kambayashi, Hiroshi Konta
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Publication number: 20100183774Abstract: This invention relates to the addition of N-acetylglucosamine to foods and beverages and to the use of N-acetylglucosamine as a sweetening agent. This invention also relates to foods and beverages prepared with N-acetylglucosamine and methods of preparing the same. This invention provides a preferable means of ingesting the desired daily amount of N-acetylglucosamine for its beneficial effects on the body, for example, alleviation of pain and inflammation in a patient suffering from inflammatory bowel disorder or osteoarthritis.Type: ApplicationFiled: March 29, 2010Publication date: July 22, 2010Inventor: Willem Wassenaar
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Patent number: 7754875Abstract: A salt of a glucosamine base having a purity of at least about 99 wt. % and a maximum halide content of about 0.01 wt. %, and an organic acid. The organic acid that is saltified with the glucosamine base is preferably a hydroxyacid or a ketoacid. Preferably, the salt is stabilized by coating the salt with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; polypropylene glycol homopolymers and copolymers; ethylcellulose; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated salt composition will be stable at ambient temperatures and upon exposure to the atmosphere.Type: GrantFiled: September 9, 2005Date of Patent: July 13, 2010Assignee: JFC Technologies, LLCInventors: Vilas M Chopdekar, Mary P. Camaga
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Patent number: 7744853Abstract: Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.Type: GrantFiled: September 27, 2005Date of Patent: June 29, 2010Assignee: Poniard Pharmaceuticals, Inc.Inventors: Sudhakar Kasina, John M. Reno, Alan R. Fritzberg, Jonathan Tait