Hetero Ring Patents (Class 544/198)
  • Patent number: 6465645
    Abstract: Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped, unscented and/or scented candle wax which is effectively stabilized against discoloration and fading by the incorporation therein of a long chain hindered amine alone or in combination with a UV absorber and/or an antioxidant.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: October 15, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Andrea R. Smith, James P. Galbo
  • Patent number: 6451737
    Abstract: The invention related to novel substituted arylsulphonyl(thio)ureas wherein: A is nitrogen or a CH grouping, Q is oxygen or sulphur, R1 is hydrogen, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy or heterocyclyloxy, R2 is hydrogen, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy or heterocyclyloxy, R3 is hydrogen or optionally substituted alkyl, R4 is optionally substituted alkyl, alkoxy, alkenyl, alkinyl, alkenyloxy, alkinyloxy, cycloalkyl, cycloalkyloxy or cycloalkylalkyl, and R5 is hydrogen, formyl or optionally substituted alkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, alkenyl, alkinyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulphonyl or heterocyclyl, and salts of compounds of the formula (I), except for the compound N-(4,6-dimethyl-pyrimidin-2-yl)-N′-[2-(1,1,2,2-tetrafluoro-ethoxy)-6-methyl-phenylsulphonyl]-urea.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: September 17, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ernst Rudolf F. Gesing, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Müller, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Ulrich Philipp, Hans-Jochem Riebel, Otto Schallner, Markus Dollinger, Hans-Joachim Santel
  • Patent number: 6444794
    Abstract: Disclosed are water-soluble dyes, such as azo dyes, metal complex dyes, anthraquinone, phthalocyanine and formazan dyes which, optionally via a bridge member, possess a fiber-reactive group of the vinyl sulfone series and further contain a 4-cyanamido-1,3,5-triazin-6-ylamino radical which is 2-substituted by a group of the general formula (2) where Rz is hydrogen, lower alkyl optionally substituted by alkyl, hydroxyl, cyano, lower alkoxy, carboxyl, sulfamoyl, sulfo or sulfato or an optionally substituted phenyl radical, or is a cyclohexyl radical or an optionally substituted phenyl radical, W is an alkyl radical which is substituted by a reactive group and may be interrupted by a hetero atom, A is zero or 1 and B is 1 or 2, subject to the proviso that the sum of (A+B) is 2.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: September 3, 2002
    Assignee: DyStar Textilfarben GmbH & Co. Deutschland KG
    Inventors: Jörg Dannheim, Stefan Ehrenberg
  • Patent number: 6423844
    Abstract: The present invention is a process for making a 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine, acid salt and a process for neutralizing the acid salt to make 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine. 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine can be used as a precursor for ingredients in propellants, explosives, pyrotechnics, gas generators, pharmaceuticals, and azo dyes. The general process involves ring closure of 2,4-diamino-6-hydrazino-s-triazine with an acid and a chemical of the general formula RCN where the R comprises a leaving group, then neutralizing said acid.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: July 23, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: William M. Koppes, Michael E. Sitzmann
  • Publication number: 20020082259
    Abstract: This invention relates to triazine compounds of formula (I): 1
    Type: Application
    Filed: November 30, 2001
    Publication date: June 27, 2002
    Inventors: M Ono, Lijun Sun, Shijie Zhang, Teresa Przewloka, David A. James, Wenli Ding, Yumiko Wada
  • Patent number: 6409941
    Abstract: A product obtainable by transferring groups of formula (G-I) being present in a block oligomer having a polydispersity {overscore (M)}w/{overscore (M)}n of 1 to 1.7 and corresponding to formula (I) to groups of formula (Gu-II), wherein R1 is a hydrocarbyl radical or —O—R1 is oxyl; said transfer is carried out by reaction of the block oligomer with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; n is a number from 2 to 14; R2 is for example C2-C12alkylene; A is for example —N(R4)(R5); R4 and R5 are for example C1-C18alkyl; R is preferably a group of formula (G-I) and B and B* have one of the meanings given for A; with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R and R2 has the same or a different meaning. The products are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: June 25, 2002
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli
  • Patent number: 6403680
    Abstract: A product obtained by 1) reacting a compound of the formula (&agr;) with a compound of the formula (&bgr;) in a stoichiometric ratio to obtain a compound of the formula (&ggr;) 2) reacting the compound of the formula (&bgr;) with the compound of the formula (&ggr;) in a molar ratio of 0.4:1 to 0.75:1; 3) reacting the end groups of the formula (&dgr;) being present in the product of the reaction 2) with e.g. dibutylamine in a molar ratio of 2:1.7 to 2:3; the reactions 1) to 3) being carried out in an organic solvent in the presence of an inorganic base; and 4) transferring the groups of the formula being present in the product of the reaction 3) to groups of the formula said transfer being carried out by reacting the product of the reaction 3) with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; R1 is in particular a hydrocarbyl radical, B is e.g.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: June 11, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli, Ivan Orban
  • Patent number: 6399047
    Abstract: Compounds of formula (I), wherein the groups are as defined in the disclosure, as well as the use thereof in cosmetic compositions and in the stabilization of synthetic polymers.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: June 4, 2002
    Assignee: 3V Sigma S.p.A.
    Inventors: Giuseppe Raspanti, Giorgio Zanchi
  • Patent number: 6399620
    Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y—A—B—D—E—F—G  (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: June 4, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary
  • Publication number: 20020055071
    Abstract: A processing composition for silver halide photographic light-sensitive materials, comprises a bis[2,6-diaminotriazin-4-yl]arylenediamine derivative having at least one of a sulfonic acid group, a carboxylic group and a hydroxyl group within the molecule. This processing composition can be applied to a color developer, a bleaching agent, a fixing agent, a bleach-fixing agent and a stabilizing agent and also to a processing agent in a concentration on use, a concentrated processing agent and a solid processing agent.
    Type: Application
    Filed: August 21, 2001
    Publication date: May 9, 2002
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Yasufumi Nakai, Keizo Kimura, Masashi Ogiyama
  • Patent number: 6376584
    Abstract: Hindered amines substituted on the N-atom with an hydroxy-substituted alkoxy moiety are particularly effective in stabilizing organic polymer compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group on the compounds adds important properties not otherwise attainable.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: April 23, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: James Peter Galbo, Gerald A. Capocci, Nancy N. Cliff, Robert E. Detlefsen, Michael P. DiFazio, Ramanathan Ravichandran, Peter Solera, Christophe Bulliard
  • Patent number: 6372729
    Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0, 1, 2, 3 or 4; R1 and R2 are each independently selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each of the aforementioned C1-12alkyl groups may optionally and each individually be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl; and each R4 independently is hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is —X—R5 or —X-Alk-R6; wherein R5 and R6 each independently are indanyl, indolyl or phenyl; each of
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: April 16, 2002
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desiré Daeyaert, Bart De Corte, Marc René De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Patent number: 6372743
    Abstract: Disclosed are compounds of the formula: where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: April 16, 2002
    Assignees: Neurogen Corporation, Pfizer Inc.
    Inventors: James W. Darrow, Stephane De Lombaert, Charles Blum, Jennifer Tran, Mark Giangiordano, David Andrew Griffith, Philip Albert Carpino
  • Publication number: 20020028329
    Abstract: The present invention relates to a light emitting element comprising at least a light emitting layer containing a light emitting material and a host material and having a light emission maximum wavelength of 500 nm or less wherein the minimum excitation triplet energy level of the host material is higher than the minimum excitation triplet energy level of the light emitting material.
    Type: Application
    Filed: July 17, 2001
    Publication date: March 7, 2002
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Toshihiro Ise, Tatsuya Igarashi, Yousuke Miyashita, Hidetoshi Fujimura, Masayuki Mishima, Hisashi Okada, Qiu Xuepeng
  • Patent number: 6340683
    Abstract: This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: January 22, 2002
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Mohammad R. Marzabadi, Stewart A. Noble, Mahesh N. Desai
  • Patent number: 6316619
    Abstract: The present invention provides a polyaminotriazine represented by the formula (I): which has low melting point and good bleeding resistance, and is capable of being fed in a liquid form; a method for producing the polyaminotriazine; and a stabilized organic material comprising an organic material and the polyaminotriazine.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: November 13, 2001
    Assignee: Sumitomo Chemical Company, Ltd.
    Inventors: Kunihito Miyake, Kenji Kimura, Chikara Ohta
  • Patent number: 6303541
    Abstract: The invention relates to novel substituted thienyl(amino)sulphonyl(thio)ureas of the formula (I) in which A represents nitrogen or a CH grouping, E represents a single bond or an NH grouping, Q represents oxygen or sulphur, R1 and R2 independently of one another represent hydrogen, halogen or in each case optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy, aryloxy or heterocyclyloxy, R3 represents hydrogen or optionally substituted alkyl, R4 and R5 independently of one another each represent cyano, halogen or represent in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and R6 represents hydrogen, cyano, halogen or represents in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and to salts of compounds of the formula (I), to processes for preparing the novel compounds and to their use as herbicides.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: October 16, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ernst Rudolf F. Gesing, Johannes Rudolf Jansen, Klaus-Helmut Müller, Ulrich Philipp, Markus Dollinger
  • Patent number: 6288228
    Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jack Henkin, Donald J. Davidson, George S. Sheppard, Keith W. Woods, Richard W. McCroskey
  • Patent number: 6284717
    Abstract: The reaction product of: (i) a polyalkenyl derivative of an ethylenically unsaturated carboxylic reagent and (ii) a compound of the formula wherein R is a linear alkylene group having at least 2 carbon atoms, a branched alkylene group having at least 3 carbon atoms, a cycloalkylene group having at least 5 carbon atoms, in which one or more of said carbon atoms may be substituted by one or more hetero atoms, or is an aromatic group or a group of the formula in which a is 1 to 6 and b is 0 to 6, wherein the groups R may be the same or different, and wherein the values of a and b may be the same or different; process for the preparation of said reaction product; lubricating oil compositions, fuel compositions and additive concentrates containing such reaction products; and use of the reaction products as dispersant additives.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: September 4, 2001
    Assignee: Infineum USA L.P.
    Inventors: Anthony E. Crane, Richard M. Scott
  • Patent number: 6265348
    Abstract: Compounds of the formula (I) and salts thereof in which R1 to R6, W, X, Y and Z are defined as in claim 1, have herbicidal or plant growth-regulatory properties. They can be prepared by processes analogous to known processes (cf. claim 5), in some cases via novel intermediate products (cf.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: July 24, 2001
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Heinz Kehne, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6265473
    Abstract: Compounds of formula (I), in which the polydispersity Mw/Mn is for example 1; n is 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 the radicals R1 are for example C1-C18alkyl or C5-C12cycloalkyl; R2 is for example C-Cl2alkylene; the radicals A and B* are independently of one another —OR3, —N(R4)(R5) or a group of formula (II); R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of formula (III) with Y being —0—, —CH2—, —CH2, —CH2— or >N—CH3; X is —0— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; R is preferably a group of formula (IV); and B has one of the meanings given for A; with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: July 24, 2001
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli
  • Patent number: 6258950
    Abstract: The invention relates to a high-pressure process for producing melamine from urea in which highly pure melamine is obtained by transferring melamine melt leaving a melamine reactor to a cooling vessel where the melamine melt is cooled to a temperature of between 1° C. and 30° C. above the melting point of melamine after which the liquid melamine can be transferred to a second cooling vessel in which vessel the melamine melt is further cooled using cold ammonia by which solid melamine is obtained.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: July 10, 2001
    Assignee: DSM N.V.
    Inventor: Julius G. T. van Wijck
  • Patent number: 6254669
    Abstract: A compound of the Formula (1) and salts thereof: wherein: Ar, Ar1, J, J1, X, X1 W, W1, L and m are as defined in the description. The compounds of Formula (1) are useful as additives in inks, especially ink jet printing inks, for reducing color bleed between adjacent printed regions. Also claimed are inks containing a compound of the Formula (1), a method of ink jet printing using the inks, a substrate printed with the ink and an ink jet printer cartridge containing the ink.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: July 3, 2001
    Assignee: Zeneca Limited
    Inventors: Aidan Joseph Lavery, Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Patent number: 6251900
    Abstract: Heterocyclic compounds in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which are represented by the Formula I or phermaceutically acceptable acid addition salts thereof: wherein X and Y respectively represent nitrogen atom or one of them represents nitrogen atom and the other represents C—R7 wherein R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino, piperidino, piperazinyl, thiomorpholino, benzimidazolyl, cyano or the like.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 26, 2001
    Assignee: Zenyaku Kogyo Kabushiki Kaisha
    Inventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Tetsuo Watanabe, Masahiro Inaba
  • Patent number: 6225378
    Abstract: A triazine compound having formula I or formula II: Wherein n is integer from 1 to 5; R1 is hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxyl; and R2 is aliphatic amine, aliphatic alcohol, alicyclic amine or alicyclic alcohol, and an epoxy resin composition containing the triazine compound. The epoxy resin composition is suitable for the preparation of the structural substrate of printed circuit boards having low dielectric constant.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: May 1, 2001
    Assignee: Industrial Technology Research Institute
    Inventors: Shin-Shin Wang, Hung-Chou Kang, Jie-Hwa Ma, Meng-Song Yin, Se-Tsun Hong, Kuo-Yuan Hsu, Kung-Lung Cheng
  • Patent number: 6204382
    Abstract: The present invention relates generally to carboxylated amino-1,3,5-triazines and the preparation thereof via carboxylation of amino-1,3,5-triazines with carbon dioxide and a base. These carboxylated amino-1,3,5-triazines find use, for example, as intermediates in the production of other useful amino-1,3,5-triazine derivatives, and particularly carbamate and isocyanate functional 1,3,5-triazines. The present invention also relates to the preparation of such carbamate and isocyanate functional 1,3,5-triazines.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: March 20, 2001
    Assignee: Cytec Technology Corp.
    Inventors: Lawrence Allen Flood, Ram Baboo Gupta
  • Patent number: 6200984
    Abstract: A compound of the general formula I: is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions, processes for preparing the compounds and methods of treatment are also disclosed.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: March 13, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, James J. McNally, Pauline Sanfilippo
  • Patent number: 6197957
    Abstract: Provided is a process for preparing carbonylated derivatives of amino- and haloamino-1,3,5-triazines by contacting the 1,3,5-triazine, carbon monoxide and a metal catalyst system containing a metal promoter for promoting carbonylation, at a temperature carbon monoxide pressure and length of time sufficient to carbonylate at least a portion of the amino and/or haloamino groups of the 1,3,5-triazine. The product resulting from contacting these components is an isocyanate functional 1,3,5-triazine; however, the carbamate functional derivative can be readily produced by contacting these components in the further presence of a hydroxy compound, or by post-reacting the isocyanate functional product with such hydroxy compound.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: March 6, 2001
    Assignee: Cytec Technology Corp.
    Inventors: Peter S. Forgione, Ram B. Gupta, Lawrence A. Flood, Donald H. Valentine
  • Patent number: 6177491
    Abstract: Compounds of formula (I), wherein n is a number from 2 to 14; R1 is for example C1-C18alkyl or C5-C12cycloalkyl; R2 is for example C2-C12alkylene; A is for example acetyl, (C1-C4alkoxy)carbonyl, (C1-C4alkyl)aminocarbonyl or C1-C4alkyl; B is —OR3, —N(R4(R5) or a group of formula (II); R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of formula (III) with Y being —O—, —CH2—, —CH2CH2— or >N—CH3; X is —O— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; and R is preferably a group of formula (IV); with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning. The indicated compounds are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: January 23, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: James Peter Galbo, Dario Lazzari, Fabrizio Guizzardi
  • Patent number: 6169086
    Abstract: The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: January 2, 2001
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Akio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito
  • Patent number: 6153672
    Abstract: A process for preparing a tris-lactam crosslinking agent, tris-pyrrolidonyl triazine, from N,N',N"-tris(4-chlorobutyryl)melamine by treatment of the chlorobutyryl derivative with a base such as sodium or potassium carbonate to effect intramolecular cyclization to the tris-lactam. A curable composition comprised of tris-pyrrolidonyl triazine as the crosslinking agent and a hydroxyfunctional or aminofunctional material as a resin. Thick films with no pinholes are prepared from the curable compositions using powder coating techniques.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: November 28, 2000
    Assignee: Cytec Technology Corp.
    Inventors: Ram B. Gupta, Robert G. Lees
  • Patent number: 6150360
    Abstract: This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0, 1, 2, 3 or 4; R.sup.1 and R.sup.2 are each independently selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 -alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each of the aforementioned C.sub.1-12 alkyl groups may optionally and each individually be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl; and each R.sup.4 independently is hydroxy, halo, C.sub.1-6 alkyl, C.sub.1-6 -alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is --X--R.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: November 21, 2000
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desire Daeyaert, Bart De Corte, Marc Rene De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Patent number: 6120562
    Abstract: Amino- and/or alkoxytriazines containing at least one C.sub.1 -C.sub.10 -alkyl group which possesses a vinylsulfonyl group or a radical capable of forming a vinylsulfonyl group and may be substituted further, are used as fixation aids when using anionic dyes on hydroxyl- or nitrogen-containing organic substrates and as crosslinkers for regenerated cellulose or materials containing cellulose.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 19, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Patsch, Reinhold Krallmann, Wolfgang Reuther, Thomas Grosser
  • Patent number: 6114420
    Abstract: A compound of the formula (I) ##STR1## wherein n is an integer from 1 to 4; the radicals R.sub.1 are for example a group of the formula ##STR2## R.sub.3 is for example hydrogen, C.sub.1 -C.sub.8 alkyl or C.sub.5 -C.sub.12 cycloalkoxy; Z and R.sub.2 are for example a group ##STR3## the radicals A and E are, for example, independently of one another --N(R.sub.11)(R.sub.12) or a group of the formula ##STR4## R.sub.11 and R.sub.12 are for example C.sub.1 -C.sub.12 alkyl; R.sub.13 has for example one of the meanings given for R.sub.3 ; E* has for example one of the meanings given for A or is a group of the formula ##STR5## The compounds of the formula (I) are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers such as polyolefins.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: September 5, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Alessandro Zedda, Gianluca Ferri
  • Patent number: 6107369
    Abstract: A process for preparing a tris-lactam crosslinking agent, tris-pyrrolidonyl triazine, from N,N',N"-tris(4-chlorobutyryl)melamine by treatment of the chlorobutyryl derivative with a base such as sodium or potassium carbonate to effect intramolecular cyclization to the tris-lactam. A curable composition comprised of tris-pyrrolidonyl triazine as the crosslinking agent and a hydroxyfunctional or aminofunctinoal material as a resin. Thick films with no pinholes are prepared from the curable compositions using powder coating techniques.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 22, 2000
    Assignee: Cytec Technology Corp.
    Inventors: R. B. Gupta, Robert G. Lees
  • Patent number: 6096244
    Abstract: The present invention relates to a melamine-polycarboxylic acid amide and its use as a corrosion protection agent. Specifically, a melamine-polycarboxylic acid amide having a particular Formula I ##STR1## as well as alkali, ammonium, and amine salts thereof.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: August 1, 2000
    Assignee: ZTS-Chemie GmbH
    Inventor: Stefan Graichen
  • Patent number: 6069114
    Abstract: Compounds of the formula (I) and their salts ##STR1## in which R.sup.1 to R.sup.6, Y.sup.1, to Y.sup.2, Y.sup.3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepared analogously to known processes using intermediates of the formula (V) (cf. claim 6).
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 30, 2000
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Klemens Minn, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6051290
    Abstract: A composition which includes the following compounds: ##STR1## wherein R.sup.1, which may be the same or different, is a hydrophilic group;R.sup.2, which may the same or different, is selected from the group consisting of electron donating groups, electron withdrawing groups, and electron neutral groups;R.sup.3 is a substituted or unsubstituted, positively charged heteroaromatic ring linked to the triazine backbone through a nitrogen atom in the R.sup.3 ring; andX.sup.- is a counterion.If R.sup.3 is an unsubstituted pyridine, the counterion X.sup.- may be selected from any counterion other than Cl.sup.- and OH.sup.-. Otherwise, the counterion X.sup.- may be selected from any counterion.The compound may be applied to a substrate to form a birefingent optical retardationdevice. The retardationdevice may be used in display devices such as computers and the like to correct the phase and polarization states of the display's emitted light and improve image quality at viewing angles away from the normal.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: April 18, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: Hassan Sahouani, Kim Marie Vogel
  • Patent number: 6036767
    Abstract: The present invention provides an aqueous pigment dispersion composition for electro-deposition color coating of an aluminum or aluminum alloy oxide film, the composition comprising an organic white pigment as an essential component thereof. The organic white pigment comprises large-diameter particles which are insoluble in a water-soluble organic liquid and/or water and exhibit a non-skinning property and a sufficient concealing power on an aluminum or aluminum alloy oxide film. More specifically, the organic white pigment particles preferably have an average particle diameters of at least 0.3 .mu.m and a reflective index of at least 1.4. The use of the aqueous pigment dispersion composition for electro-deposition coating ensures formation of a less lustrous, less transparent and highly weather-resistant coating film for coloration of an aluminum or aluminum alloy oxide film.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: March 14, 2000
    Assignee: Sakura Color Products Corporation
    Inventors: Shigeyasu Inoue, Tadaaki Ito
  • Patent number: 6013797
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: January 11, 2000
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh
  • Patent number: 5998446
    Abstract: There are described compounds of the general formula I ##STR1## where the index and the substituents have the following meanings: R is cyano, halogen, alkyl or alkoxy;n is 0, 1 or 2, it being possible for the substituents R to differ from each other if n is 2;Het is a 5-membered heteroaromatic ring having three nitrogen atoms or two nitrogen atoms and one oxygen or sulfur atom and having attached to it an unsubstituted or substituted 6-membered aromatic or heteroaromatic ring;processes for their preparation, and their use.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: December 7, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Wassilios Grammenos, Bernd Muller, Hubert Sauter, Klaus Oberdorf, Hartmann Konig, Norbert Gotz, Michael Rack, Gisela Lorenz, Eberhard Ammermann, Siegfried Strathmann
  • Patent number: 5972248
    Abstract: The present invention relates to novel stabilizers of the formula (I) ##STR1## in which the substituents have the meaning defined in the description. These novel stabilizers are particularly suitable for stabilizing organic material, such as plastics, oils, paints and coatings, against degradation by light, radiation, heat and oxygen.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: October 26, 1999
    Assignee: Clariant GmbH
    Inventors: Thomas Stahrfeldt, Josef Wiedemann, Matthias Zah
  • Patent number: 5965641
    Abstract: A description is given of a process for stabilising an organic polymer against ozone in the ambient air, which comprises adding to the polymer as stabiliser a monomeric sterically hindered piperidine compound, or an oligomeric or polymeric sterically hindered piperidine compound containing one or several triazine units, or a secondary sterically hindered piperidine compound, the piperidine compound containing in any case at least one unit of formula I ##STR1## wherein G is hydrogen or methyl, and G.sub.1 and G.sub.2 are hydrogen, methyl or, taken together, oxygen.With this process it is possible to make a more accurate prediction of the service time of the polymer and it helps to avoid unnecessarily high dosages of the stabiliser.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: October 12, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fran.cedilla.ois Gugumus
  • Patent number: 5948910
    Abstract: Water-soluble perylene dyestuffs, their preparation and their useThe present Application relates to water-soluble perylene dyestuffs of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another are the radicals A--X--COOM or A--X--SO.sub.3 M;R.sup.3 and R.sup.4 independently of one another are the radicals R.sup.1 or R.sup.2, or are OR.sup.5 or NR.sup.6 R.sup.7 ;A is NR.sup.8 or S;X is a straight-chain or branched alkylene radical, a straight-chain or branched alkylene radical which is substituted by hydroxyl, carboxyl or amino, an arylene radical or an arylene radical which is optionally substituted by hydroxyl, carboxyl or sulfo;R.sup.5, R.sup.6 and R.sup.7 independently of one another are hydrogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkyl which is substitituted by one or more hydroxyl, 2-hydroxyethoxy, (C.sub.1 -C.sub.4)-alkoxy or amino groups;R.sup.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Clariant GmbH
    Inventors: Wolfgang Bauer, Dieter Baumgart, Dieter Schnaitmann, Klaus-Peter Kreutzer, Walter Zoller
  • Patent number: 5936085
    Abstract: Disclosed and claimed is a process for the preparation of a carbamate (IV)Ar--O--CO--NR--B (IV)by reaction of a saltM.sup..sym. .crclbar.NR--B (II-S)with a diaryl carbonate(ArO).sub.2 CO (III).The carbamate can be reacted, without any necessity of intermediate isolation, with a sulfonamide A--SO.sub.2 NH.sub.2 (V) to give a sulfonylurea (I) or salts thereofA--SO.sub.2 --NH--CO--NR--B (I).And thus, disclosed and claimed too is a process for the preparation of sulfonylurea (I) by (i) contacting a salt (II-S) with a diaryl carbonate (III) to form a carbamate (IV), and (ii) contacting carbamate (IV) from step (i) with or without intermediate isolation, with a sulfonamide (V). These processes avoid the use of alkali metal hydrides as a base. And, these processes can additionally include the preparation of salt (II-S) from a compound H--NR--B (II) and base M.sup..sym. Base.sup..crclbar..
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: August 10, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Gerhard Schnabel, Harald Knorr, Klemens Minn, Jan Vermehren
  • Patent number: 5922122
    Abstract: A composition containing an organic pigment and a compound having the formula (I): ##STR1## in which R.sup.1 is a group having the formula (II): ##STR2## in which R.sup.4 and R.sup.5 represent hydrogen or alkyl, or R.sup.4 and R.sup.5 are bonded to each other to form a ring together with a nitrogen atom, X represents alkylene or alkyleneoxyalkylene, and Y represents --O--, --S-- or a group represented by --NR.sup.6 -- wherein R.sup.6 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 represent a group having the formula (II), alkyl, aralkyl, aryl, alkoxy, aralkyloxy, aryloxy, alkylamino, arylamino or a halogen atom. A photosensitive colored composition is made of the composition, a polymer having acidic group, a photopolymerizable monomer and a photopolymerization initiator.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 13, 1999
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Akihiko Takeda, Takekatsu Sugiyama
  • Patent number: 5919929
    Abstract: A process for the preparation of a product corresponding to the formula (I) ##STR1## wherein n is a number from 2 to 50; the radicals R.sub.1 are for example 2,2,6,6-tetramethyl-4-piperidyl, R.sub.2 is for example hexamethylene and E is for example t-octylamino; which comprisesa) reacting a compound of the formula (A) ##STR2## with a compound of the formula (B) ##STR3## in a molar ratio of 1:1.7 to 1:4; and b) reacting the product obtained in a) with a compound of the formula (C) ##STR4## to obtain the product corresponding to the formula (I), the molar ratio of the compound of the formula (C) to the compound of the formula (A) being 2:1 to 1:5; the reactions a) and b) being carried out in an organic solvent, in the presence of an inorganic base and in an inert atmosphere.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: July 6, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Marco Tomei
  • Patent number: 5852015
    Abstract: This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 22, 1998
    Assignee: American Cyanamid Company
    Inventors: Yakov Gluzman, deceased, James P. LaRocque, Bryan M. O'Hara, John E. Morin, George A. Ellestad, Boris Mitsner, Wei-Dong Ding, Yuri E. Raifeld, Antonina A. Nikitenko
  • Patent number: 5847132
    Abstract: Compounds of the formula (I) ##STR1## wherein n is a number from 1 to 20;the radicals R.sub.1 are independently of one another hydrogen, C.sub.1 -C.sub.8 alkyl, --O, --OH, --CH.sub.2 CN, C.sub.1 -C.sub.18 alkoxy, C.sub.5 -C.sub.12 cycloalkoxy, C.sub.3 -C.sub.6 alkenyl, C.sub.7 -C.sub.9 phenylalkyl which is unsubstituted or substituted on the phenyl by 1, 2 or 3 C.sub.1 -C.sub.4 alkyl; or C.sub.1 -C.sub.8 acyl;R.sub.2 has one of the meanings given for R.sub.1 ;X is C.sub.2 -C.sub.10 alkylene; andY is --O-- or >NH;with the proviso that in the individual recurrent units of the formula (I), each of the radicals R.sub.1, R.sub.2, X and Y has the same or different definitions;are very effective as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 8, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Fabrizio Guizzardi, Nicola Lelli
  • Patent number: 5807929
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 15, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh