Chalcogen Bonded Directly To Triazine Ring Carbon Patents (Class 544/219)
  • Patent number: 6255484
    Abstract: A cyanurate compound having three oxetane ring groups and represented by the general formula (1): wherein R1 represents a member selected from the group consisting of a hydrogen atom and alkyl groups having 1 to 6 carbon atoms, is useful as a photosetting monomer or thermosetting monomer, and thus is used, together with a hardening agent, for example, a polycarboxylic anhydride and a catalyst, for example, an amine, a carboxylic acid metal salt or a protonic acid, to provide an organic hardening composition usable for producing electronic materials, for example, resists.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: July 3, 2001
    Assignee: Ube Industries, Ltd.
    Inventors: Mikito Kashima, Yumiki Noda, Harutoshi Hoshino, Toshikazu Machida
  • Patent number: 6254669
    Abstract: A compound of the Formula (1) and salts thereof: wherein: Ar, Ar1, J, J1, X, X1 W, W1, L and m are as defined in the description. The compounds of Formula (1) are useful as additives in inks, especially ink jet printing inks, for reducing color bleed between adjacent printed regions. Also claimed are inks containing a compound of the Formula (1), a method of ink jet printing using the inks, a substrate printed with the ink and an ink jet printer cartridge containing the ink.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: July 3, 2001
    Assignee: Zeneca Limited
    Inventors: Aidan Joseph Lavery, Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Patent number: 6251916
    Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: June 26, 2001
    Assignee: UCB, S. A.
    Inventors: Gurmit Grewal, Anna Toy-Palmer, Xiong Cai, George Mark Latham
  • Patent number: 6242598
    Abstract: A process for preparing 2-(2,4-dihydroxyphenyl)-4.6-diaryl-s-triazines in three steps starting with cyanuric chloride is described. Step 1 involves the nucleophilic (basic) displacement of one chlorine atom with a phenolic moiety. Step 2 involves a Friedel-Crafts reaction using a Lewis acid catalyst (preferably aluminum chloride) to replace the remaining two chlorine atoms with aryl groups such as xylyl. Finally, step 3 involves replacing the phenolic moiety with resorcinol using either a Lewis acid or protic acid catalyst or combinations thereof. Some additional processes only peripherally related to the three-step process outlined above are also described for the preparation of various s-triazine compounds. The s-triazines prepared are useful as UV absorbers for the stabilization of organic substrates against the adverse effects of actinic light.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: June 5, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Tyler Arthur Stevenson, Michael Ackerman, Pascal Hayoz, Roger Meuwly, John Francis Oswald, Christian Schregenberger
  • Patent number: 6235790
    Abstract: Hydroxamic acid derivatives of the general formula (I), in which Z, G, Ar, E, A1 and A have the meanings given in the description, to a process for their preparation, and to their use as pesticides, particularly as fungicides.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: May 22, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Krüger, Lutz Assmann, Herbert Gayer, Peter Gerdes, Ulrich Heinemann, Dietmar Kuhnt, Thomas Seitz, Bernd Gallenkamp, Ral Tiemann, Gerd Hänssler, Heinz-Wilhelm Dehne, Stefan Dutzmann
  • Patent number: 6191131
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: February 20, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Liqi He, Paul Gilligan, Robert Chorvat, Argyrios Georgios Arvanitis
  • Patent number: 6187944
    Abstract: Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. wherein Q is Y is ═C(R4)— or ═N—, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen, alkyl which may be substituted, alkenyl which may be substituted, etc., R4 is hydrogen, halogen, alkyl or haloalkyl, 1 is from 1 to 4, m is from 0 to 5, n is from 0 to 3, q is from 0 to 4, when 1 is 2 or more, a plurality of R2 may be the same or different, when each of m, n and q is 2 or more, a plurality of R3 may be the same or different.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: February 13, 2001
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Toru Koyanagi, Yuji Nakamura, Masayuki Morita, Koji Sugimoto, Tsuyoshi Ikeda, Munekazu Ogawa
  • Patent number: 6177491
    Abstract: Compounds of formula (I), wherein n is a number from 2 to 14; R1 is for example C1-C18alkyl or C5-C12cycloalkyl; R2 is for example C2-C12alkylene; A is for example acetyl, (C1-C4alkoxy)carbonyl, (C1-C4alkyl)aminocarbonyl or C1-C4alkyl; B is —OR3, —N(R4(R5) or a group of formula (II); R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of formula (III) with Y being —O—, —CH2—, —CH2CH2— or >N—CH3; X is —O— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; and R is preferably a group of formula (IV); with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning. The indicated compounds are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: January 23, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: James Peter Galbo, Dario Lazzari, Fabrizio Guizzardi
  • Patent number: 6174940
    Abstract: The present invention relates to mixtures comprising the compound I in a proportion of 65-95% by weight, the compound II in a proportion of 5-35% by weight and the compound III in a proportion of 0-10% by weight wherein the substituents are as defined in the description, and to mixtures with other compounds. The mixtures are suitable for stabilizing organic material against the effect of light and heat.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: January 16, 2001
    Assignee: Clariant GmbH
    Inventors: Thomas St{umlaut over (a)}hrfeldt, Mathias Mehrer, Matthias Z{umlaut over (a)}h, Gerhard Pfahler
  • Patent number: 6166014
    Abstract: This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: December 26, 2000
    Assignee: Berlex Laboratories, Inc.
    Inventors: Monica J. Kochanny, Michael M. Morrissey, Howard P. Ng
  • Patent number: 6159980
    Abstract: Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: December 12, 2000
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Argyrios Georgios Arvanitis, Richard E. Olson, Charles R. Arnold, III, William E. Frietze
  • Patent number: 6150382
    Abstract: This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: November 21, 2000
    Assignee: Berlex Laboratories, Inc.
    Inventors: Monica J. Kochanny, Michael M. Morrissey, Howard P. Ng
  • Patent number: 6143060
    Abstract: Triazine derivatives of general formula (I); and recording materials excellent in the storage stability of developed images, particularly the resistance thereof to plasticizers.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: November 7, 2000
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Hiroshi Fujii, Tomoya Hidaka, Shinichi Sato, Izuo Aoki
  • Patent number: 6130231
    Abstract: This invention relates to novel fused heterocycles which are useful as antagonists of the .alpha..sub.v .beta..sub.3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 10, 2000
    Assignee: DuPont Pharmaceuticals
    Inventors: John Wityak, Aleksandra Ewa Tobin
  • Patent number: 6121201
    Abstract: A compound represented by the formula (I) or its salt and herbicidal and desiccant use thereof: ##STR1## wherein X, Y are independently hydrogen, halogen, cyano, nitro, or (C.sub.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: September 19, 2000
    Assignee: Ishihara Sangyo Kaisha, Ltd.
    Inventors: David A. Pulman, Bai-Ping Ying, Shao-Yong Wu, Sandeep Gupta, Masamitsu Tsukamoto, Takahiro Haga
  • Patent number: 6111103
    Abstract: The invention relates to diresorcinyl-alkoxy- and -aryloxy-triazines of the formula ##STR1## in which R.sub.1 is C.sub.2 -C.sub.30 alkyl; C.sub.2 -C.sub.30 alkenyl; unsubstituted or C.sub.1 -C.sub.5 alkyl-mono- or polysubstituted C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.5 alkoxy-C.sub.1 -C.sub.12 alkyl; amino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 monoalkylamino-C.sub.1 -C.sub.12 alkyl; C.sub.1 -C.sub.5 dialkylamino-C.sub.1 -C.sub.12 alkyl; a radical of the formula ##STR2## R.sub.2, R.sub.3 and R.sub.4, independently of one another, are hydrogen, hydroxyl, C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.30 alkenyl,R.sub.5 is hydrogen; or C.sub.1 -C.sub.5 alkyl;m.sub.1 is 0 or 1; andn.sub.1 is 1 to 5.The novel compounds are suitable as cosmetic UV-A absorbers.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: August 29, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Thomas Ehlis, Elek Borsos, Helmut Luther, Bernd Herzog
  • Patent number: 6107251
    Abstract: The present invention is directed to oxazole derivatives represented by the formula [I]; ##STR1## wherein A represents a nitrogen atom or a R.sub.3 -substituted carbon atom;B represents a nitrogen atom, or an unsubstituted or X-substituted carbon atom;Z represents an oxygen atom, sulfinyl or sulfonyl;R.sub.1 and R.sub.2 represent each independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 haloalkoxy, C.sub.1 -C.sub.6 haloalkyl or the like;R.sub.3 represents hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro, formyl or acyl;X represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.1 -C.sub.6 haloalkyl or the like;Y represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.1 -C.sub.6 haloalkyl or the like;m represents an integer of 1 or 2, andn represents an integar of 1, 2, 3 or 4, and the salts thereof.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: August 22, 2000
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Akiyoshi Ueda, Yasuyuki Miyazawa, Yoshihiko Hara, Masami Koguchi, Akihiro Takahashi, Takashi Kawana
  • Patent number: 6075142
    Abstract: A process for producing tris(tribromophenoxy)-s-triazine. The process is characterized in that cyanuric chloride and an aqueous tribromophenolate solution are subjected to reaction in the presence of a tertiary amine. According to this process, the reaction goes to completion in a short time and the yield and purity of the product are high.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: June 13, 2000
    Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.
    Inventors: Setsuo Nishibori, Hideto Kondo
  • Patent number: 6071912
    Abstract: This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: June 6, 2000
    Assignee: Berlex Laboratories, Inc.
    Inventors: Monica Kochanny, Raju Mohan, Michael M. Morrissey, Howard P. Ng, Weiya Yun
  • Patent number: 6066597
    Abstract: New herbicidal pyridine and pyrimidine derivatives of general formula (I), ##STR1## wherein Z represents a nitrogen atom or a C--H group; A represents an optionally substituted aryl group or an optionally substituted 5- or 6-membered nitrogen-containing heteroaromatic group; n represents an integer from 0 to 2 and R.sup.1 or each R.sup.1 independently represents a hydrogen atom or an optionally substituted alkyl, alkoxy, alkylthio or dialkylamino group; m represents an integer from 0 to 5 and R.sup.2 or each R.sup.2 independently represents a hydrogen or a halogen atom or an optionally substituted alkyl, haloalkyl, haloalkoxy, alkoxy, alkylthio group or a nitro, cyano or a halosulphonyl group; and X represents an oxygen or sulphur atom.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: May 23, 2000
    Assignee: American Cyanamid Company
    Inventors: Axel Kleemann, Helmut Siegfried Baltruschat, Thekla Haselwander
  • Patent number: 6060492
    Abstract: The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formula II: ##STR1## The variables in Formula II are defined herein.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: May 9, 2000
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Thomas Alan Crowell, Donald Paul Matthews, John Hampton McDonald, III, David Andrew Neel, Anthony John Shuker, Mark Alan Winter
  • Patent number: 6057444
    Abstract: A process is described for the preparation of an aryl-1,3-5-triazine compound of formula (1). This process comprises reacting an aldehyde compound of formula (2) with biuret, compound of formula (3), in hydrochloric medium or with methyl sulfate (1.sup.st reaction step), then oxidizing the resulting compound of formula (4) to the compound of formula (5) or (6) (2.sup.nd reaction step) and subsequently chlorinating the compound so obtained to the compound of formula (1) (3.sup.rd reaction step) according to the following scheme: ##STR1## In the above scheme: R.sub.1 and R.sub.2 are each independently of the other hydrogen; hydroxy or C.sub.1 -C.sub.5 alkoxy. The compounds of formula (1) are used as UV absorbers or as starting products for the preparation of UV absorbers.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: May 2, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Jurg Haase, Tanja Mossner
  • Patent number: 6046227
    Abstract: The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta..sub.3 receptor agonists useful in the treatment of Type II diabetes and obesity.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: April 4, 2000
    Assignee: Eli Lilly and Company
    Inventors: Thomas Alan Crowell, Charles David Jones, Anthony John Shuker
  • Patent number: 6025491
    Abstract: Onium salts of taxo-diterpenoid-C.sup.n, 2-0-aza-arenes are employed as water soluble prodrugs. For example, taxol-2'-methylpyridiniumtosylate (MPT) is characterized by an elevated aqueous solubility, rapid activation by serum protein, good stability in most other aqueous solutions, formation of a protein:taxol intermediate and good retension within the circulatory system. The toxicity of the activated form is comparable or greater than underivatized taxol. Furthermore, taxol-2'-MPT can be synthesized by a simple one step reaction between taxol and 2-fluoro-1-MPT. The invention is applicable to taxol and taxol mimetics having hydroxyls that are reactive with onium salts of 2-halogenated-aza-arenes. For example, taxol, C-2 substituted analogs of taxol, and Taxotere each have reactive hydroxyls at the 2' and 7 positions. The invention is also applicable to a wide array of 2-halogenated-aza-arenes.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: February 15, 2000
    Assignee: The Scripps Research Institute
    Inventors: Kyriacos C. Nicolaou, Wolfgang Wrasidlo, Rodney K. Guy, Emmanuel Pitsinos
  • Patent number: 6022870
    Abstract: Cyclic amides of Formula I which are useful as fungicides: ##STR1## wherein A is N; G is N and the floating double bond is attached to A; W is O or S; X is OR.sup.1, S(O).sub.m R.sup.1 or halogen; R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z are defined in the disclosure, are disclosed. Also, disclosed are fungicidal compositions containing these compounds and the use of these cyclic amide compounds for controlling plant diseases caused by fungal plant pathogens.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: February 8, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Richard James Brown, King-Mo Sun, Deborah Ann Frasier
  • Patent number: 6013704
    Abstract: There are described compounds of formula A whereinr.sub.1 and r.sub.2 are each independently of the other 0 or 1;Y.sub.1 to Y.sub.9 are each independently of the others --H, --OH, C.sub.1 -C.sub.20 alkyl, C.sub.4 -C.sub.20 cycloalkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.1 -C.sub.20 alkoxy, C.sub.4 -C.sub.12 cycloalkoxy, C.sub.2 -C.sub.20 alkenyloxy, C.sub.7 -C.sub.20 aralkyl, halogen, --C.tbd.N, C.sub.1 -C.sub.5 haloalkyl, --SO.sub.2 R', --SO.sub.3 H, --SO.sub.3 M, wherein M is an alkali metal, --COOR', --CONHR', --CONR'R", --OCOOR', --OCOR', --OCONHR', (meth)acrylamino, (meth)-acryloxy, C.sub.6 -C.sub.12 aryl; C.sub.6 -C.sub.12 aryl substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy, CN and/or by halogen; C.sub.3 -C.sub.12 heteroaryl; C.sub.3 -C.sub.12 heteroaryl substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy, CN and/or by halogen; or Q of formula I, and at least one substituent Y.sub.1 to Y.sub.9 must be Q ##STR1## wherein q is 0 or 1,R is a cyclic radical andR.sub.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: January 11, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Pascal Hayoz, Andreas Valet, Vien Van Toan
  • Patent number: 5994352
    Abstract: Compounds of the formula ##STR1## wherein A, B, D, E, and F are each independently nitrogen or carbon; R.sub.1 is hydrogen, C.sub.1 to C.sub.6 alkyl, --(CH.sub.2).sub.n R.sub.7, or C.sub.1 to C.sub.3 alkyl-aryl; R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each independently hydrogen, C.sub.1 to C.sub.6 alkyl, aryl, C.sub.1 to C.sub.3 alkyl-aryl, halogen, cyano, nitro, --(CH.sub.2).sub.m NR.sub.8 R.sub.9, --(CH.sub.2).sub.m OR.sub.9, --SR.sub.9, --SO.sub.2 NR.sub.8 R.sub.9, --(CH.sub.2).sub.m NR.sub.8 SO.sub.2 R.sub.9, --(CH.sub.2).sub.m NR.sub.8 CO.sub.2 R.sub.9, --(CH.sub.2).sub.m NR.sub.8 COR.sub.9, --(CH.sub.2).sub.m CONR.sub.7 R.sub.9, or --(CH.sub.2).sub.m CO.sub.2 R.sub.9 ; R.sub.2 and R.sub.3, R.sub.3 and R.sub.4, R.sub.4 and R.sub.5, and R.sub.5 and R.sub.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: November 30, 1999
    Assignee: Pfizer Inc.
    Inventor: John Eugene Macor
  • Patent number: 5985903
    Abstract: Novel benzotriazoles of the formula ##STR1## in which R, X.sup.1, X.sup.2, X.sup.3, X.sup.4 and Y have the meanings given in the description,and their acid addition salts and metal salt complexes,a process for the preparation of these substances and their use as microbicides in crop protection and in material protection.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: November 16, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz Assmann, Ralf Tiemann, Martin Kugler, Heinrich Schrage, Klaus Stenzel
  • Patent number: 5968482
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 19, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Patent number: 5969134
    Abstract: Carboxylic acid derivatives ##STR1## where R-R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: October 19, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hartmut Riechers, Dagmar Klinge, Wilhelm Amberg, Andreas Kling, Stefan Muller, Ernst Baumann, Joachim Rheinheimer, Uwe Josef Vogelbacher, Wolfgang Wernet, Liliane Unger, Manfred Raschack
  • Patent number: 5965731
    Abstract: In an aqueous reaction medium, phenol is brominated with bromine under conditions forming an aqueous hydrobromic acid phase and an organic phase consisting essentially of molten 2,4,6-tribromophenol. The aqueous hydrobromic acid phase and the molten 2,4,6-tribromophenol are separated from each other, and optionally the molten 2,4,6-tribromophenol is washed with an aqueous decolorizing solution. An alkali metal base and water are mixed with the 2,4,6-tribromophenol to form an alkali metal salt of tribromophenol. Then, in a mixture consisting essentially of water and at least one liquid ketone, cyanuric chloride is reacted with at least a portion of the alkali metal 2,4,6-tribromophenolate of such that tris(2,4,6-tribromophenoxy)-s-1,3,5-triazine is produced.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: October 12, 1999
    Assignee: Albemarle Corporation
    Inventors: Meng-Sheng Ao, Billie B. Dadgar, Phillip R. Beaver, Mark W. Beltz
  • Patent number: 5962683
    Abstract: A description is given of compounds of the formula I ##STR1## where r is 0 or 1 and y is a number from the range 1-3; X is a direct bond or --NR.sub.8 --, --CO--, --CONH-- or --COO-- or a divalent aliphatic or mixed aromatic-aliphatic C.sub.1 -C.sub.18 hydrocarbon radical;Z is an aromatic, aliphatic or mixed aromatic-aliphatic C.sub.3 -C.sub.18 hydrocarbon radical which is interrupted in the aliphatic moiety by one or more divalent functional groups, in each case in a carbon-carbon single bond, and/or in the aromatic or aliphatic moiety by one or more divalent functional groups, in each case in a carbon-hydrogen bond, possible functional groups being --O--, --NR.sub.8 --, --S--, --SO--, --SO.sub.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: October 5, 1999
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Alfred Steinmann, Rolf Mulhaupt
  • Patent number: 5959106
    Abstract: N-(substituted aryl)?1,2,4!triazoloazinesulfonamide compounds, such as N-(2,6-difluorophenyl)-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine- 2-sulfonamide, were prepared at a good reaction rate and in good yield by the reaction of a chlorosulfonyl?1,2,4!triazoloazine compound, such as 2-chlorosulfonyl-8-fluoro-5-methoxy?1,2,4!triazolo?1,5-c!pyrimidine, and an arylamine compound, such as 2,6-difluoroaniline, in an organic medium containing a relatively acidic alcohol, such as propylene glycol or 2,2,2-trifluoroethanol.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: September 28, 1999
    Assignee: Dow AgroSciences LLC
    Inventors: Douglas L. Pearson, Timothy J. Adaway
  • Patent number: 5942509
    Abstract: Fungicidal compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CA wherein A is H, halogen, C.sub.1-4 alkyl, cyano, nitro or trifluoromethyl; X is a linking group other than oxygen; T is oxygen or sulphur; and Z is an optionally substituted carbocyclic or heterocyclic ring.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: August 24, 1999
    Assignee: Zeneca Limited
    Inventors: John Martin Clough, Christopher Richard Ayles Godfrey, Paul John De Fraine, Ian Thomas Streeting, Gordon Richard Munns
  • Patent number: 5939443
    Abstract: The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formula II: ##STR1## The variables in Formula II are defined herein.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: August 17, 1999
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Thomas Alan Crowell, Christine Ann Droste, Donald Paul Matthews, John Hampton McDonald, III, Christopher John Rito, Anthony John Shuker, Mark Alan Winter
  • Patent number: 5925597
    Abstract: Compounds of the formula (I) and their salts as defined in claim 1, ##STR1## in which R.sup.1 is CO--Q--R.sup.8, where R.sup.8 =H or RR.sup.2 and R.sup.3 are H or (C.sub.1 -C.sub.4)alkyl,R.sup.4 is H, R, RO, OH, RCO, RSO.sub.2, PhSO.sub.2R.sup.5 is RSO.sub.2, PhSO.sub.2, PhCO, RNHSO.sub.2, R.sub.2 NSO.sub.2, RCO, CHO, COCOR', CW--T--R.sup.9, CW--NR.sup.10 R.sup.11, CW--N(R.sup.12).sub.2 orR.sup.4 and R.sup.5 together are the chain (CH.sub.2).sub.m B or --B.sup.1 --(CH.sub.2).sub.m1 B-- where B=SO.sub.2, CO; m=3, 4; m.sup.1 =2, 3;T and W=O, S; Q=O, S, NR.sup.13 where R.sup.13 =H, R;R.sup.6 =H, R, RO, RCO, ROCO, Hal, NO.sub.2, CN;R.sup.7 =H, CH.sub.3 ; R.sup.9 =R; R.sup.10, R.sup.11 =H, R; N(R.sup.12).sub.2 =heterocycleA=pyrimidinyl and triazinyl radical or an analog thereof,where R=(substituted) aliphatic hydrocarbon radical, are suitable as selective herbicides. They are prepared by analogous processes via sulfonamides, some of which are new, of the formula (II).
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: July 20, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Lothar Willms, Klaus Bauer, Hermann Bieringer
  • Patent number: 5922710
    Abstract: Iminooxybenzylcrotonate esters of the formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4;R is nitro, cyano, halogen,unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy orin the case where n is 2, additionally an unsubst. or subst. bridge bonded to two adjacent ring atoms;R.sup.1 is C.sub.1 -C.sub.4 -alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl;R.sup.3 is hydrogen, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or cycloalkyl;R.sup.4 is a 5 to 10-membered mono- or bicyclic, substituted heteroaromatic ring system,processes for their preparation and their use are described.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: July 13, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Muller, Wassilios Grammenos, Hubert Sauter, Franz Rohl, Eberhard Ammermann, Gisela Lorenz, Norbert Gotz
  • Patent number: 5919929
    Abstract: A process for the preparation of a product corresponding to the formula (I) ##STR1## wherein n is a number from 2 to 50; the radicals R.sub.1 are for example 2,2,6,6-tetramethyl-4-piperidyl, R.sub.2 is for example hexamethylene and E is for example t-octylamino; which comprisesa) reacting a compound of the formula (A) ##STR2## with a compound of the formula (B) ##STR3## in a molar ratio of 1:1.7 to 1:4; and b) reacting the product obtained in a) with a compound of the formula (C) ##STR4## to obtain the product corresponding to the formula (I), the molar ratio of the compound of the formula (C) to the compound of the formula (A) being 2:1 to 1:5; the reactions a) and b) being carried out in an organic solvent, in the presence of an inorganic base and in an inert atmosphere.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: July 6, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Marco Tomei
  • Patent number: 5907040
    Abstract: A process for producing tris(tribromophenoxy)-s-triazine. The process is characterized in that cyanuric chloride and an aqueous tribromophenolate solution are subjected to reaction in the presence of a tertiary amine. According to this process, the reaction goes to completion in a short time and the yield and purity of the product are high.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: May 25, 1999
    Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.
    Inventors: Setsuo Nishibori, Hideto Kondo
  • Patent number: 5892065
    Abstract: A 2,3-epoxypropyl derivative or a 2-methyl-2,3-epoxypropyl derivative of a compound having carboxyl groups or amido groups is produced as a purified product having an epoxide equivalent of 1.0 to 1.1 times the theoretical epoxide equivalent of the derivative, an ionic halogen content of 10 ppm or less, transparency when molten and a stability against increase in the epoxide equivalent when stored at 150.degree. C. for 24 hours, by a process comprising steps (A) reacting 1.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: April 6, 1999
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Suketoshi Tsukamoto, Takami Ono, Hisao Ikeda, Motohiko Hidaka
  • Patent number: 5885935
    Abstract: Herbicidal sulfonamides of the formula: ##STR1## and salts thereof, where: A represents a substituted or unsubstituted benzene ring, or a 5- or 6-membered substituted or unsubstituted heteroaromatic ring; Q is --O--, --S-- or a group --CXX'--; X and X', which may be the same or different, are each hydrogen, halogen, cyano, an optionally-substituted alkyl group, or a group --OR.sup.a, --SR.sup.a, or --COR.sup.b ; or one of X and X' represents hydroxy and the other is as defined above; or X and X' together represent .dbd.O or .dbd.S; R.sup.a is an optionally-substituted alkyl, aryl or acyl group; R.sup.b is an optionally-substituted alkyl or aryl group, or a group --OR.sup.c or --NR.sup.c R.sup.d ; R.sup.c and R.sup.d, which may be the same or different, are each hydrogen, or an optionally-substituted alkyl or aryl group; Y is nitrogen or a group CR.sup.9 ; R.sup.1 is an optionally-substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, benzoheterocyclyl or amino group; R.sup.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: March 23, 1999
    Assignee: Agrevo UK Limited
    Inventors: Peter Stuart Gates, Graham Peter Jones, David Edward Saunders
  • Patent number: 5886176
    Abstract: The invention relates to a novel process for preparing herbicidal sulphonylurea salts of the formula (I) ##STR1## in which M.sup.+ represents an alkali metal ion or an alkaline earth metal ion equivalent,Z represents N, CH or C-halogen,R.sup.1 represents in each case optionally substituted aryl, aralkyl or heteroaryl,(where R.sup.2, X and Y have the meanings given in the description).
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: March 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventor: Klaus-Helmut Muller
  • Patent number: 5852015
    Abstract: This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 22, 1998
    Assignee: American Cyanamid Company
    Inventors: Yakov Gluzman, deceased, James P. LaRocque, Bryan M. O'Hara, John E. Morin, George A. Ellestad, Boris Mitsner, Wei-Dong Ding, Yuri E. Raifeld, Antonina A. Nikitenko
  • Patent number: 5824677
    Abstract: Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.13. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 20, 1998
    Assignee: Cell Therapeutics, Inc.
    Inventors: J. Peter Klein, Gail E. Underiner, Anil M. Kumar
  • Patent number: 5773445
    Abstract: The application describes new 3-methoxy-2-phenyl-acrylic esters of the formula (I) ##STR1## in which R and Y have the meanings given in the description,a process for their preparation, and their use as pesticides.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: June 30, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Gayer, Peter Gerdes, Otto Schallner, Stefan Dutzmann, Heinz-Wilhelm Dehne, Gerd Hanssler
  • Patent number: 5770544
    Abstract: A condensed heterocyclic derivative of the formula ##STR1## (wherein R is a hydroxyl group, R.sup.3 or R.sup.4 is an alkoxy group, W is an oxygen atom, Yn is a hydrogen atom, Z is a methine group, and A is a 5- or 6-membered heterocyclic ring which may be substituted, and a herbicide, are presented. When used for paddy field treatment, upland soil treatment and foliage treatment, the condensed heterocyclic derivative of the present invention exhibits excellent herbicidal activities against gramineous and non-gramineous weeds without adversely affecting crop plants.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: June 23, 1998
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Sumio Yokota, Masafumi Matsuzawa, Nobuyuki Ohba, Toshihiro Nagata, Shigehiko Tachikawa, Takeshige Miyazawa, Katsutada Yanagisawa
  • Patent number: 5750469
    Abstract: Substituted lactic acid derivatives having an N-organic radical in the .beta.-position, of the formula I ##STR1## where substituents R to R.sup.5, X and Y have the meanings mentioned in the description and N is one of the radicals:a) --N.sub.3, --NC, --NCS or --NCOb) ##STR2## where R.sup.14 and R.sup.15 have the meanings described in the descriptionc) ##STR3## in which R.sup.16 is hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl or unsubstituted or substituted phenyl; andB is a group ##STR4## OR.sup.19 or --NR.sup.14 R.sup.15, where R.sup.14, R.sup.15, R.sup.17 and R.sup.19 have the meanings described in the description, or ##STR5## where R.sup.14 and R.sup.15.sub.1, have the abovementioned meanings; or ##STR6## where R.sup.20 and R.sup.21, which can be identical or different, are: hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or phenyl, where the organic radicals can in each case be substituted;or R.sup.20 and R.sup.21 together form an unsubstituted or substituted C.sub.4 -C.sub.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: May 12, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Ernst Baumann, Joachim Rheinheimer, Uwe Josef Vogelbacher, Matthias Gerber, Wilhelm Rademacher, Helmut Walter, Karl-Otto Westphalen
  • Patent number: 5736628
    Abstract: The present invention is directed to novel benzenesulfonylurea derivatives having herbicidal activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Dae-Whang Kim, Young Kwan Ko, Jin-Seog Kim, Dong Whan Ku
  • Patent number: 5723067
    Abstract: Tris-(cyanato)-s-triazines having the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently of one another, represent halogen, in particular, chlorine, bromine and fluorine, hydrogen or a methyl group or ethyl group. The monomers disclosed always provide an anisotropic network. Methods for the polycyclotrimerization of polycyanates to obtain the inventive compounds are also disclosed.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: March 3, 1998
    Assignee: Europaeische Wirtschaftsgemeinschaft
    Inventors: Werner Mormann, Joerg Zimmermann
  • Patent number: 5723473
    Abstract: A fungicidal compound of formula (I): ##STR1## wherein A is hydrogen, halogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylcarbonyl, C.sub.1-4 alkoxycarbonyl, phenoxy, nitro or cyano; and one of R.sup.1 and R.sup.2 is optionally substituted isoquinoline while the other is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, halogen or cyano.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: March 3, 1998
    Assignee: Zeneca Limited
    Inventor: Brian Leslie Pilkington